Search our Database of Scientific Publications and Authors

I’m looking for a

    21960 results match your criteria Viral Hemorrhagic Fevers

    1 OF 440

    Reemergence of yellow fever in Ethiopia after 50 years, 2013: epidemiological and entomological investigations.
    BMC Infect Dis 2017 May 15;17(1):343. Epub 2017 May 15.
    Regional Health Bureau of the Southern Nations Nationalities and Peoples-Ethiopia, Dakar, Senegal.
    Background: Yellow Fever (YF) is a viral hemorrhagic disease transmitted by aedes mosquito species. Approximately, 200,000 cases and 30,000 deaths occur worldwide every year. In Ethiopia, the last outbreak was reported in 1966 with 2200 cases and 450 deaths. Read More

    Regulation of Tacaribe Mammarenavirus Translation: Positive 5' and Negative 3' Elements, and Role of Key Cellular Factors.
    J Virol 2017 May 3. Epub 2017 May 3.
    Centro de Virología Animal (CEVAN), Instituto de Ciencia y Tecnología Dr. Cesar Milstein, Consejo Nacional de Ciencia y Tecnología (CONICET), Ciudad Autónoma de Buenos Aires (CABA), Argentina
    Mammarenaviruses are enveloped viruses with a bisegmented negative-stranded RNA genome that encodes the nucleocapsid protein (NP), the envelope glycoprotein precursor (GPC), the RNA polymerase (L), and a RING matrix protein (Z). Viral proteins are synthesized from subgenomic messenger RNAs bearing a capped 5' untranslated region (UTR), and lacking 3' poly(A) tail. We analyzed the translation strategy of Tacaribe virus (TCRV), a prototype of the New World mammarenaviruses. Read More

    Viral exanthems: An update on laboratory testing of the adult patient.
    J Am Acad Dermatol 2017 Mar 26;76(3):538-550. Epub 2016 Oct 26.
    Division of Dermatology, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, Columbus, Ohio. Electronic address:
    Although classic viral exanthems of childhood are well described, they are rarely differentiated in adults. Laboratory techniques for viral identification have advanced without substantial literature to suggest how a dermatologist ought to conduct a cost-effective and diagnostic viral panel. Certain clinical features such as petechiae, vesicles, and dusky macular or morbilliform exanthems point strongly toward a viral exanthem. Read More

    Management of dengue in Australian travellers: a retrospective multicentre analysis.
    Med J Aust 2017 Apr;206(7):295-300
    Austin Health, Melbourne, VIC.
    Objectives: To describe the epidemiology, clinical and laboratory features and outcomes of dengue in returned Australian travellers, applying the revised WHO dengue classification (2009) to this population.

    Design, Setting And Participants: Retrospective case series analysis of confirmed dengue cases hospitalised at one of four Australian tertiary hospitals, January 2012 - May 2015.

    Main Outcome Measures: Clinical features, laboratory findings and outcomes of patients with dengue; dengue classification according to 2009 WHO guidelines. Read More

    Clinical and Laboratory Diagnosis of Dengue Virus Infection.
    J Infect Dis 2017 Mar;215(suppl_2):S89-S95
    Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane,Australia.
    Infection with any of the 4 dengue virus serotypes results in a diverse range of symptoms, from mild undifferentiated fever to life-threatening hemorrhagic fever and shock. Given that dengue virus infection elicits such a broad range of clinical symptoms, early and accurate laboratory diagnosis is essential for appropriate patient management. Virus detection and serological conversion have been the main targets of diagnostic assessment for many years, however cross-reactivity of antibody responses among the flaviviruses has been a confounding issue in providing a differential diagnosis. Read More

    Case Management of Dengue: Lessons Learned.
    J Infect Dis 2017 Mar;215(suppl_2):S79-S88
    Dengue Unit, Queen Sirikit National Institute of Child Health, Bangkok, Thailand ; and.
    The global burden of dengue and its geographic distribution have increased over the past several decades. The introduction of dengue in new areas has often been accompanied by high case-fatality rates. Drawing on the experience in managing dengue cases at the Queen Sirikit National Institute of Child Health in Bangkok, Thailand, this article provides the authors' perspectives on key clinical lessons to improve dengue-related outcomes. Read More

    Advances in Vector Control Science: Rear-and-Release Strategies Show Promise… but Don't Forget the Basics.
    J Infect Dis 2017 Mar;215(suppl_2):S103-S108
    College of Public Health, Medical and Veterinary Sciences and.
    Both chikungunya and Zika viruses have recently swept from Africa across the Pacific to the Americas, causing major outbreaks of disease in humans. In the meantime, dengue epidemics continue throughout the tropics. Traditional vector control programs based on strategies from 1950s and 1960s have been relatively ineffective in combating recent epidemics. Read More

    Current Status of Dengue Therapeutics Research and Development.
    J Infect Dis 2017 Mar;215(suppl_2):S96-S102
    Programme in Emerging Infectious Diseases, Duke-National University of Singapore Medical School.
    Dengue is a significant global health problem. Even though a vaccine against dengue is now available, which is a notable achievement, its long-term protective efficacy against each of the 4 dengue virus serotypes remains to be definitively determined. Consequently, drugs directed at the viral targets or critical host mechanisms that can be used safely as prophylaxis or treatment to effectively ameliorate disease or reduce disease severity and fatalities are still needed to reduce the burden of dengue. Read More

    Cooperativity Enables Non-neutralizing Antibodies to Neutralize Ebolavirus.
    Cell Rep 2017 Apr;19(2):413-424
    Integrated BioTherapeutics, Inc., Rockville, MD 20850, USA. Electronic address:
    Drug combinations are synergistic when their combined efficacy exceeds the sum of the individual actions, but they rarely include ineffective drugs that become effective only in combination. We identified several "enabling pairs" of neutralizing and non-neutralizing anti-ebolavirus monoclonal antibodies, whose combination exhibited new functional profiles, including transforming a non-neutralizing antibody to a neutralizer. Sub-neutralizing concentrations of antibodies 2G4 or m8C4 enabled non-neutralizing antibody FVM09 (IC50 >1 μM) to exhibit potent neutralization (IC50 1-10 nM). Read More

    A live-attenuated Zika virus vaccine candidate induces sterilizing immunity in mouse models.
    Nat Med 2017 Apr 10. Epub 2017 Apr 10.
    Department of Biochemistry &Molecular Biology, University of Texas Medical Branch, Galveston, Texas, USA.
    Zika virus (ZIKV) infection of pregnant women can cause a wide range of congenital abnormalities, including microcephaly, in the infant, a condition now collectively known as congenital ZIKV syndrome. A vaccine to prevent or significantly attenuate viremia in pregnant women who are residents of or travelers to epidemic or endemic regions is needed to avert congenital ZIKV syndrome, and might also help to suppress epidemic transmission. Here we report on a live-attenuated vaccine candidate that contains a 10-nucleotide deletion in the 3' untranslated region of the ZIKV genome (10-del ZIKV). Read More

    Taxonomy of the order Mononegavirales: update 2017.
    Arch Virol 2017 Apr 7. Epub 2017 Apr 7.
    Integrated Research Facility at Fort Detrick (IRF-Frederick), Division of Clinical Research (DCR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), B-8200 Research Plaza, Fort Detrick, Frederick, MD, 21702, USA.
    In 2017, the order Mononegavirales was expanded by the inclusion of a total of 69 novel species. Five new rhabdovirus genera and one new nyamivirus genus were established to harbor 41 of these species, whereas the remaining new species were assigned to already established genera. Furthermore, non-Latinized binomial species names replaced all paramyxovirus and pneumovirus species names, thereby accomplishing application of binomial species names throughout the entire order. Read More

    Yellow Fever Virus Modulates the Expression of Key Proteins Related to the microRNA Pathway in the Human Hepatocarcinoma Cell Line HepG2.
    Viral Immunol 2017 Apr 7. Epub 2017 Apr 7.
    1 Section of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute , Ananindeua, Brazil .
    Yellow fever is a zoonotic disease caused by the yellow fever virus (YFV) and transmitted by mosquitoes of the family Culicidae. It is well known that cellular and viral microRNAs (miRNAs) are involved in modulation of viral and cellular gene expression, as well as immune response, and are considered by the scientific community as possible targets for an effective therapy against viral infections. This regulation may be involved in different levels of infection and clinical symptomatology. Read More

    Viral hemorrhagic fevers in the Tihamah region of the western Arabian Peninsula.
    PLoS Negl Trop Dis 2017 Apr 6;11(4):e0005322. Epub 2017 Apr 6.
    Biology and Medical Research Unit, Life Sciences Division, CNESTEN, Rabat, Morocco.
    Viral hemorrhagic fever (VHF) refers to a group of diseases characterized by an acute febrile syndrome with hemorrhagic manifestations and high mortality rates caused by several families of viruses that affect humans and animals. These diseases are typically endemic in certain geographical regions and sometimes cause major outbreaks. The history of hemorrhagic fever in the Arabian Peninsula refers to the 19th century and most outbreaks were reported in the Tihamah region-the Red Sea coastal plain of the Arabian Peninsula in the west and southwest of Saudi Arabia and Yemen. Read More

    Spatial-temporal diffusion of dengue in the municipality of Rio de Janeiro, Brazil, 2000-2013.
    Cad Saude Publica 2017 Mar 30;33(2):e00186615. Epub 2017 Mar 30.
    Instituto de Comunicação e Informação Científica e Tecnológica em Saúde, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil.
    The city of Rio de Janeiro, Brazil, shows high potential receptiveness to the introduction, dissemination, and persistence of dengue transmission. The pattern of territorial occupation in the municipality produced a heterogeneous and diverse mosaic, with differential vector distribution between and within neighborhoods, producing distinct epidemics on this scale of observation. The study seeks to identify these epidemics and the pattern of spatial and temporal diffusion of dengue transmission. Read More

    Prevalence and titers of yellow fever virus neutralizing antibodies in previously vaccinated adults.
    Rev Inst Med Trop Sao Paulo 2017 Apr 3;59:e2. Epub 2017 Apr 3.
    Universidade de São Paulo, Faculdade de Medicina, Departamento de Moléstias Infecciosas e Parasitárias, São Paulo, SP, Brazil.
    Introduction:: The World Health Organization (WHO) recommends one single dose of the Yellow Fever (YF) vaccine based on studies of antibody persistency in healthy adults. We assessed the prevalence and titers of YF virus neutralizing antibodies in previously vaccinated persons aged  60 years, in comparison to younger adults. We also evaluated the correlation between antibody titers and the time since vaccination among participants who received one vaccine dose, and the seropositivity among participants vaccinated prior to or within the past 10 years. Read More

    Catalase protects Aedes aegypti from oxidative stress and increases midgut infection prevalence of Dengue but not Zika.
    PLoS Negl Trop Dis 2017 Apr 5;11(4):e0005525. Epub 2017 Apr 5.
    Laboratório de Bioquímica de Artrópodes Hematófagos, Instituto de Bioquímica Médica Leopoldo de Meis, Programa de Biologia Molecular e Biotecnologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil.
    Background: Digestion of blood in the midgut of Aedes aegypti results in the release of pro-oxidant molecules that can be toxic to the mosquito. We hypothesized that after a blood meal, the antioxidant capacity of the midgut is increased to protect cells against oxidative stress. Concomitantly, pathogens present in the blood ingested by mosquitoes, such as the arboviruses Dengue and Zika, also have to overcome the same oxidative challenge, and the antioxidant program induced by the insect is likely to influence infection status of the mosquito and its vectorial competence. Read More

    Multi-walled carbon nanotubes functionalized with recombinant Dengue virus 3 envelope proteins induce significant and specific immune responses in mice.
    J Nanobiotechnology 2017 Apr 4;15(1):26. Epub 2017 Apr 4.
    Laboratory of Basic and Applied Virology, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
    Background: Dengue is the most prevalent arthropod-borne viral disease in the world. In this article we present results on the development, characterization and immunogenic evaluation of an alternative vaccine candidate against Dengue.

    Methods: The MWNT-DENV3E nanoconjugate was developed by covalent functionalization of carboxylated multi-walled carbon nanotubes (MWNT) with recombinant dengue envelope (DENV3E) proteins. Read More

    Socioeconomic and environmental determinants of dengue transmission in an urban setting: An ecological study in Nouméa, New Caledonia.
    PLoS Negl Trop Dis 2017 Apr 3;11(4):e0005471. Epub 2017 Apr 3.
    Epidemiology of Infectious Diseases Expertise and Research Unit, Institut Pasteur in New Caledonia, Institut Pasteur International Network, Nouméa, New Caledonia.
    Background: Dengue is a mosquito-borne virus that causes extensive morbidity and economic loss in many tropical and subtropical regions of the world. Often present in cities, dengue virus is rapidly spreading due to urbanization, climate change and increased human movements. Dengue cases are often heterogeneously distributed throughout cities, suggesting that small-scale determinants influence dengue urban transmission. Read More

    Yellow Fever Outbreak - Kongo Central Province, Democratic Republic of the Congo, August 2016.
    MMWR Morb Mortal Wkly Rep 2017 Mar 31;66(12):335-338. Epub 2017 Mar 31.
    On April 23, 2016, the Democratic Republic of the Congo's (DRC's) Ministry of Health declared a yellow fever outbreak. As of May 24, 2016, approximately 90% of suspected yellow fever cases (n = 459) and deaths (45) were reported in a single province, Kongo Central Province, that borders Angola, where a large yellow fever outbreak had begun in December 2015. Two yellow fever mass vaccination campaigns were conducted in Kongo Central Province during May 25-June 7, 2016 and August 17-28, 2016. Read More

    The ongoing evolution of antibody-based treatments for Ebola virus infection.
    Immunotherapy 2017 Mar;9(5):435-450
    Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada.
    The 2014-2016 Ebola virus outbreak in West Africa was the deadliest in history, prompting the evaluation of various drug candidates, including antibody-based therapeutics for the treatment of Ebola hemorrhagic fever (EHF). Prior to 2014, only convalescent blood products from EHF survivors had been administered to newly infected individuals as a form of treatment. However, during the recent outbreak, monoclonal antibody cocktails such as ZMapp, ZMAb and MB-003 were either tested in a human clinical safety and efficacy trial or provided to some based on compassionate grounds. Read More

    Assessing spatio-temporal trend of vector breeding and dengue fever incidence in association with meteorological conditions.
    Environ Monit Assess 2017 Apr 28;189(4):189. Epub 2017 Mar 28.
    Sustainable Development Study Center, Government College University, Katchery Road, Lahore, 54000, Pakistan.
    Th aim of this study is to investigate spatio-temporal trends of dengue vector breeding and epidemic (disease incidence) influenced by climatic factors. The spatio-temporal (low-, medium-, and high-intensity periods) evaluation of entomological and epidemiological investigations along with climatic factors like rainfall (RF), temperature (Tmax), relative humidity (RH), and larval indexing was conducted to develop correlations in the area of Lahore, Pakistan. The vector abundance and disease transmission trend was geo-tagged for spatial insight. Read More

    Infections associated with adventure travel: A systematic review.
    Travel Med Infect Dis 2017 Mar - Apr;16:3-10. Epub 2017 Mar 27.
    University of Alabama at Birmingham, 1900 University Blvd, THT 229, Birmingham, AL 35294, United States. Electronic address:
    Aim: To review infections associated with adventure travel.

    Methods: The PubMed, Embase and Scopus databases were searched combining the words infection with the following keywords: rafting, whitewater, surfing, (surfer* or windsurf*), (caves or caving or spelunking), (triathlon or trekking) or (hiking or adventure race), bicycling, backpacking, (mountain climb* or bouldering), horseback riding, orienteering, trekking, and skiing.

    Results: Adventure travel is becoming much more common among travelers and it is associated with a subset of infectious diseases including: leptospirosis, schistosomiasis, viral hemorrhagic fevers, rickettsial diseases and endemic mycosis. Read More

    Rapid detection and quantification of Ebola Zaire virus by one-step real-time quantitative reverse transcription-polymerase chain reaction.
    Microbiol Immunol 2017 Apr;61(3-4):130-137
    Department of Virology and Immunology, Texas Biomedical Research Institute 7620 NW Loop 410, San Antonio, TX78227, USA.
    Given that Ebola virus causes severe hemorrhagic fever in humans with mortality rates as high as 90%, rapid and accurate detection of this virus is essential both for controlling infection and preventing further transmission. Here, a one-step qRT-PCR assay for rapid and quantitative detection of an Ebola Zaire strain using GP, VP24 or VP40 genes as a target is introduced. Routine assay conditions for hydrolysis probe detection were established from the manufacturer's protocol used in the assays. Read More

    Undiagnosed acute HIV infection identified through RNA testing of pooled serum samples obtained during a dengue outbreak in São Paulo, Brazil.
    Rev Soc Bras Med Trop 2017 Jan-Feb;50(1):110-112
    Centro de Virologia, Instituto Adolfo Lutz, São Paulo, São Paulo, Brasil.
    Introduction:: Improving HIV diagnostics and treatment is necessary to end the AIDS epidemic. Pooled plasma can be used to identify patients with acute HIV disease, even before serological tests. During dengue outbreaks, patients having symptoms common to other acute viral diseases might seek medical care. Read More

    Spatial-temporal analysis of dengue deaths: identifying social vulnerabilities.
    Rev Soc Bras Med Trop 2017 Jan-Feb;50(1):104-109
    Programa de Pós-Graduação em Saúde e Ambiente, Universidade Federal do Maranhão, São Luis, Maranhão, Brasil.
    Introduction: Currently, dengue fever, chikungunya fever, and zika virus represent serious public health issues in Brazil, despite efforts to control the vector, the Aedes aegypti mosquito.

    Methods:: This was a descriptive and ecological study of dengue deaths occurring from 2002 to 2013 in São Luis, Maranhão, Brazil. Geoprocessing software was used to draw maps, linking the geo-referenced deaths with urban/social data at census tract level. Read More

    Molecular and clinical epidemiological surveillance of dengue virus in Paraíba, Northeast Brazil.
    Rev Soc Bras Med Trop 2017 Jan-Feb;50(1):19-26
    Laboratório de Imunologia das Doenças Infecciosas, Departamento de Biologia Celular e Molecular, Universidade Federal da Paraíba, João Pessoa, PB, Brasil.
    Introduction:: Despite being the most prevalent arboviral disease worldwide, dengue has been neglected lately. However, recent epidemics of arboviruses such as Zika and chikungunya in locations throughout the world have alerted health authorities to these diseases. This study evaluated the incidence pattern of dengue, its clinical characteristics, and co-circulation of serotypes from 2007 to 2015 in Paraiba State, Northeast Brazil. Read More

    Keeping track of hidden dangers - The short history of the Sabiá virus.
    Rev Soc Bras Med Trop 2017 Jan-Feb;50(1):3-8
    Laboratório de Imunogenética, Programa de Pós-Graduação em Genética e Biologia Molecular, Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
    Emerging infectious diseases are a global threat. In countries like Brazil, where biodiversity is high and public health conditions in terms of infrastructure and medical care are often precarious, emerging diseases are particularly worrisome. The lack of monitoring strategies to identify pathogens with the potential to cause outbreaks or epidemics is another problem in Brazil and other developing countries. Read More

    Capillary leak syndrome: etiologies, pathophysiology, and management.
    Kidney Int 2017 Mar 16. Epub 2017 Mar 16.
    Columbia University Medical Center, New York, New York, USA. Electronic address:
    In various human diseases, an increase in capillary permeability to proteins leads to the loss of protein-rich fluid from the intravascular to the interstitial space. Although sepsis is the disease most commonly associated with this phenomenon, many other diseases can lead to a "sepsis-like" syndrome with manifestations of diffuse pitting edema, exudative serous cavity effusions, noncardiogenic pulmonary edema, hypotension, and, in some cases, hypovolemic shock with multiple-organ failure. The term capillary leak syndrome has been used to describe this constellation of disease manifestations associated with an increased capillary permeability to proteins. Read More

    The Statesmanship of William Crawford Gorgas, M.D., Surgeon General, Medical Corps, United States Army.
    Am Surg 2017 Mar;83(3):221-232
    If statesmanship can be characterized as a bed rock of principles, a strong moral compass, a vision, and an ability to articulate and effect that vision, then the fortitude, tenacity, imperturbability, and resilience of William Crawford Gorgas cannot be overestimated. As Chief Sanitary Officer in Cuba and as Chief Medical Officer in Panama, he actualized strategies to eradicate the vectors of yellow fever and malaria. His superiors initially pigeonholed his requisitions, refused to provide him with any authority, and clamored for his dismissal. Read More

    Platelets and infections in the resource-limited countries with a focus on malaria and viral haemorrhagic fevers.
    Br J Haematol 2017 Mar 14. Epub 2017 Mar 14.
    Department of Haematology, Manchester Royal Infirmary, Manchester, UK.
    Infections continue to cause a high incidence of mortality and morbidity in resource-poor nations. Although antimicrobial therapy has aided mostly in dealing with the pathogenic micro-organisms themselves, the collateral damage caused by the infections continue to cause many deaths. Intensive care support and manipulation of the hosts' abnormal response to the infection have helped to improve mortality in well-resourced countries. Read More

    Mathematical Modelling of Immune Parameters in the Evolution of Severe Dengue.
    Comput Math Methods Med 2017 15;2017:2187390. Epub 2017 Feb 15.
    Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
    Aims. Predicting the risk of severity at an early stage in an individual patient will be invaluable in preventing morbidity and mortality caused by dengue. We hypothesized that such predictions are possible by analyzing multiple parameters using mathematical modeling. Read More

    How does the dengue vector mosquito Aedes albopictus respond to global warming?
    Parasit Vectors 2017 Mar 11;10(1):140. Epub 2017 Mar 11.
    College of Global Change and Earth System Science, Beijing Normal University, Beijing, 100875, China.
    Background: Global warming has a marked influence on the life cycle of epidemic vectors as well as their interactions with human beings. The Aedes albopictus mosquito as the vector of dengue fever surged exponentially in the last decade, raising ecological and epistemological concerns of how climate change altered its growth rate and population dynamics. As the global warming pattern is considerably uneven across four seasons, with a confirmed stronger effect in winter, an emerging need arises as to exploring how the seasonal warming effects influence the annual development of Ae. Read More

    Surveillance report of Zika virus among Canadian travellers returning from the Americas.
    CMAJ 2017 Mar;189(9):E334-E340
    Department of Medicine (Boggild, Chakrabarti, Kain), Tropical Disease Unit, Division of Infectious Diseases, University Health Network and University of Toronto; Public Health Ontario Laboratories (Boggild), Public Health Ontario, Toronto, Ont.; Office of Border and Travel Health (Geduld), Public Health Agency of Canada, Ottawa, Ont.; The J.D. MacLean Centre for Tropical Diseases (Libman, Yansouni), McGill University, Montréal, Que.; Tropical Medicine and International Health Clinic (McCarthy), Division of Infectious Diseases, Ottawa Hospital and University of Ottawa, Ottawa, Ont.; Division of Infectious Diseases (Hajek, Mirzanejad), University of British Columbia, Vancouver, BC; Infectious Diseases (Ghesquiere), Vancouver Island Health Authority, Victoria, BC; Department of Medicine (Ghesquiere), University of British Columbia, Vancouver, BC; Fraser Health (Mirzanejad), Surrey, BC; Hôpital Saint-Luc du CHUM (Vincelette), Université de Montréal, Montréal, Que.; Departments of Pediatrics and Medicine (Kuhn), Section of Pediatric Infectious Diseases, Alberta Children's Hospital and University of Calgary, Calgary, Alta.; Travel Health and Tropical Medicine Services (Plourde), Population and Public Health Program, Winnipeg Regional Health Authority, Winnipeg, Man.; Trillium Health Partners (Chakrabarti), Mississauga, Ont.; Department of Medicine (Freedman), Center for Geographic Medicine, University of Alabama Birmingham, Birmingham, Ala.; SAR Laboratories (Kain), Sandra Rotman Centre, Toronto, Ont.
    Background: Widespread transmission of Zika virus in the Americas has occurred since late 2015. We examined demographic and travel-related characteristics of returned Canadian travellers with Zika infection acquired in the Americas to illuminate risk factors for acquisition and the clinical spectrum.

    Methods: We analyzed demographic and travel-related data for returned Canadian travellers who presented to a CanTravNet site between October 2015 and September 2016 for care of Zika virus acquired in the Americas. Read More

    Arboviral diseases and malaria in Australia, 2013-14: Annual report of the National Arbovirus and Malaria Advisory Committee.
    Commun Dis Intell Q Rep 2016 Sep 30;40(3):E400-E436. Epub 2016 Sep 30.
    Royal Darwin Hospital Northern Territory; Menzies School of Health Research, Darwin, Northern Territory.
    This report describes the epidemiology of mosquito-borne diseases of public health importance in Australia during the 2013-14 season (1 July 2013 to 30 June 2014) and includes data from human notifications, sentinel chicken, vector and virus surveillance programs. The National Notifiable Diseases Surveillance System received notifications for 8,898 cases of disease transmitted by mosquitoes during the 2013-14 season. The Australasian alphaviruses Barmah Forest virus and Ross River virus accounted for 6,372 (72%) total notifications. Read More

    Insufficient efficacy and safety of intravenous ribavirin in treatment of haemorrhagic fever with renal syndrome caused by Puumala virus.
    Infect Dis (Lond) 2017 Jul 3;49(7):514-520. Epub 2017 Mar 3.
    b Laboratory for Zoonoses , Central Research Institute of Epidemiology , Moscow , Russia.
    Background: Intravenous ribavirin has been reported to be an effective treatment for haemorrhagic fever with renal syndrome (HFRS) caused by Hantaan virus in Asia. However, its therapeutic benefits for HFRS caused by Puumala virus (PUUV) in Europe are still unknown.

    Methods: A randomized, open-label study of efficacy and safety of intravenous ribavirin in the treatment of HFRS was conducted in the European part of Russia. Read More

    Experiences and perceptions of the United States Ebola Active Monitoring Program: results from a survey of Former Persons Under Monitoring in Washington, DC.
    Public Health 2017 Mar 5;144:70-77. Epub 2017 Jan 5.
    District of Columbia Department of Health, Center for Policy, Planning and Evaluation, Washington, DC, USA.
    Objectives: To assess Former Persons Under Monitoring (FPUM)s' experiences and perceptions of the United States (US) Ebola Active Monitoring Program.

    Study Design: Retrospective assessment survey of FPUM.

    Methods: An electronic survey was distributed to FPUMs monitored in Washington, DC, during October 2014-September 2015 (n = 830). Read More

    "Preliminary Seroepidemiological survey of dengue infections in Pakistan, 2009-2014".
    Infect Dis Poverty 2017 Mar 9;6(1):48. Epub 2017 Mar 9.
    Department of Microbiology, Quaid-i-Azam University, Islamabad, Pakistan.
    Background: Dengue virus is the causative agent of dengue fever, a vector borne infection which causes self-limiting to life threatening disease in humans. A sero-epidemiological study was conducted to understand the current epidemiology of dengue virus in Pakistan which is now known as a dengue endemic country after its first reported outbreak in 1994.

    Methods: To investigate the prevalence of dengue virus in Pakistan during 2009-2014, a total of 9,493 blood samples were screened for the detection of anti-dengue IgM antibodies using ELISA. Read More

    Quality control and data validation procedure in large-scale quantitative monitoring of mosquito density: the case of Aedes albopictus in Emilia-Romagna region, Italy.
    Pathog Glob Health 2017 Mar;111(2):83-90
    a Department Medical and Veterinary Entomology , Centro Agricoltura Ambiente "G.Nicoli", Sustenia , Crevalcore , Italy.
    The risk of local transmission of chikungunya, dengue, and Zika viruses from viremic travelers arriving from affected areas is a real possibility in southern Europe, due to the large presence of the vector Aedes albopictus. The first chikungunya outbreak in Europe occurred in the Emilia-Romagna region, Italy, in 2007, prompting the regional public health department to implement an Ae. albopictus monitoring and control plan. Read More

    [Confirmed Dengue, Chikungunya and Zika Cases during the Period 2014 to 2016 in Barcelona, Spain].
    Rev Esp Salud Publica 2017 Mar 7;91. Epub 2017 Mar 7.
    Servicio de Epidemiología. Agencia de Salud Pública de Barcelona. Barcelona. España.
    Objective: Arbovirus infections are a group of diseases whose incidence is increasing and that entail an important problem for public health. The aim of this study was to describe detected cases of arbovirosis in Barcelona, and surveillance and control actions performed in order to reduce the risk of transmission.

    Methods: Descriptive cross-sectional study of confirmed dengue, chikungunya and Zika cases in Barcelona during 2014-2016 (1st trimester). Read More

    New Virus Genome Sequences of the Guama Serogroup (Genus Orthobunyavirus, Family Bunyaviridae), Isolated in the Brazilian Amazon Region.
    Genome Announc 2017 Mar 2;5(9). Epub 2017 Mar 2.
    Department of Arbovirology and Hemorrhagic Fevers, Evandro Chagas Institute, Ministry of Health, Ananindeua, Pará, Brazil.
    This is the first announcement of two nearly complete viral genome sequences belonging to the Guama serogroup (genus Orthobunyavirus, family Bunyaviridae) isolated in the Brazilian Amazon region: Mirim virus (MIRV; BEAN7722) and Ananindeua virus (ANUV; BEAN109303). Read More

    Sasang Medical Perspectives on Viral Immunity: A Discussion of Intrinsic, Constitutionally Related Factors in Disease Onset and Resistance.
    J Acupunct Meridian Stud 2017 Jan 15;10(1):1-4. Epub 2016 Sep 15.
    The American Institute of Korean Traditional Medicine, West Linn, OR, USA. Electronic address:
    There remain more questions than answers regarding the manifestation of certain diseases, such as Ebola, in some otherwise healthy individuals but not in others. Sasang medicine offers a possible clue to solving this mystery by introducing a constitutionally based, intrinsic approach to determining disease susceptibility. The Sasang constitution is identified by a detailed examination of inherent physiological and psychological traits that are likely, but not yet, to be associated with specific genetic patterns. Read More

    Differentiating between dengue fever and malaria using hematological parameters in endemic areas of Thailand.
    Infect Dis Poverty 2017 Mar 2;6(1):27. Epub 2017 Mar 2.
    Medical Technology Program, School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, 80161, Thailand.
    Background: Dengue fever (DF) and malaria are the two major public health concerns in tropical countries such as Thailand. Early differentiation between dengue and malaria could help clinicians to identify patients who should be closely monitored for signs of dengue hemorrhagic fever or severe malaria. This study aims to build knowledge on diagnostic markers that are used to discriminate between the infections, which frequently occur in malaria-endemic areas, such as the ones in Thailand. Read More

    Hemorrhagic fever of bunyavirus etiology: disease models and progress towards new therapies.
    J Microbiol 2017 Mar 28;55(3):183-195. Epub 2017 Feb 28.
    Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, 84326, USA.
    A growing number of bunyaviruses are known to cause viral hemorrhagic fever (VHF), a severe febrile illness which can progress to hypovolemic shock and multi-organ failure and is characterized by hematologic abnormalities and vascular leak. At present, there are no approved vaccines or antiviral therapies to effectively prevent or treat VHF caused by pathogenic bunyaviruses. Advances in the modeling of bunyaviral infections have facilitated efforts towards the development of novel post-exposure prophylactic and therapeutic countermeasures, several of which may some day be approved for human use. Read More

    1 OF 440