Interactome analysis of the lymphocytic choriomeningitis virus nucleoprotein in infected cells reveals ATPase Na+/K+ transporting subunit Alpha 1 and prohibitin as host-cell factors involved in the life cycle of mammarenaviruses.
- Masaharu Iwasaki,
- Petra Minder,
- Yíngyún Caì,
- Jens H Kuhn,
- John R Yates,
- Bruce E Torbett,
- Juan C de la Torre
PLoS Pathog 2018 Feb 20;14(2):e1006892. Epub 2018 Feb 20.
Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America.
Several mammalian arenaviruses (mammarenaviruses) cause hemorrhagic fevers in humans and pose serious public health concerns in their endemic regions. Additionally, mounting evidence indicates that the worldwide-distributed, prototypic mammarenavirus, lymphocytic choriomeningitis virus (LCMV), is a neglected human pathogen of clinical significance. Concerns about human-pathogenic mammarenaviruses are exacerbated by of the lack of licensed vaccines, and current anti-mammarenavirus therapy is limited to off-label use of ribavirin that is only partially effective. Read More