24,784 results match your criteria Viral Hemorrhagic Fevers
Vet Pathol 2018 Oct 21:300985818806049. Epub 2018 Oct 21.
1 Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, Pretoria, Gauteng, South Africa.
Rift Valley fever (RVF) is a mosquito-borne disease that affects both ruminants and humans, with epidemics occurring more frequently in recent years in Africa and the Middle East, probably as a result of climate change and intensified livestock trade. Sheep necropsied during the 2010 RVF outbreak in South Africa were examined by histopathology and immunohistochemistry (IHC). A total of 124 sheep were available for study, of which 99 cases were positive for RVF. Read More
Cell Host Microbe 2018 Oct;24(4):487-499.e5
Department of Biochemistry & Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA; Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX, USA; Sealy Center for Structural Biology & Molecular Biophysics, University of Texas Medical Branch, Galveston, TX, USA; Department of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX, USA. Electronic address:
Zika virus (ZIKV) infection of the mother during pregnancy causes devastating Zika congenital syndrome in the offspring. A ZIKV vaccine with optimal safety and immunogenicity for use in pregnant women is critically needed. Toward this goal, we have developed a single-dose live-attenuated vaccine candidate that infects cells with controlled, limited infection rounds. Read More
BMC Infect Dis 2018 Oct 3;18(1):498. Epub 2018 Oct 3.
Department of Immunology and Molecular Biology, School of Biomedical Sciences, College of Health Sciences, Makerere University, P o Box 7072, Kampala, Uganda.
Background: Ebolavirus and Marburgvirus are genera of the virus family Filoviridae. Filoviruses cause rare but fatal viral hemorrhagic fevers (VHFs) in remote villages of equatorial Africa with potential for regional and international spread. Point-of-care (POC) rapid diagnostic tests (RDTs) are critical for early epidemic detection, reponse and control. Read More
Rev Inst Med Trop Sao Paulo 2018 13;60:e48. Epub 2018 Sep 13.
Programa de Pós-Graduação em Saúde Coletiva, Universidade de Fortaleza, Fortaleza, Ceará, Brazil.
The present report shows the occurrence of thrombotic thrombocytopenic purpura (TTP) associated with acute dengue and chikungunya virus coinfection, manifesting as a severe disease with high mortality potential. The patient was a 28 year-old man with clinical and epidemiological diagnosis of arboviruses infections who developed thrombocytopenia and anemia, after which oral corticosteroid therapy was started. On the third day of hospitalization, he showed neurological alterations that simulated a cerebral vascular accident, but the imaging examination did not identify ischemic or hemorrhagic alterations. Read More
Pan Afr Med J 2018 24;30:56. Epub 2018 May 24.
Nigeria Field Epidemiology Training Program, 50 Haile Selassie, Asokoro, Abuja, Nigeria.
Introduction: Hospital-acquired infections of Lassa fever (LF) have been described in many West African countries. We assessed the availability of Infection Prevention and Control (IPC) measures and their use in the health centres (HCs) at the affected Local Government Areas (LGAs) during an ongoing LF outbreak in Ondo State, Nigeria.
Methods: We included all primary and secondary HCs and their healthcare workers (HCWs) in the affected Ose and Owo LGAs. Read More
Pan Afr Med J 2018 21;30:50. Epub 2018 May 21.
Department of Community Health, College of Medical Sciences, School of Medicine, University of Benin, Benin City, Nigeria.
Introduction: Ebola Virus Disease (EVD) is of great public health importance. Health care workers (HCWs) in various health care facilities especially in developing countries such as Nigeria, are particularly vulnerable to the disease. It is therefore imperative that health care workers adopt the necessary preventive practices to reduce to the barest minimum the risk of infection transmission. Read More
BMC Bioinformatics 2018 Sep 4;19(1):312. Epub 2018 Sep 4.
Transversal activities in applied genomics, Sciensano, (1050), Brussels, Belgium.
Background: Viral infection by dengue virus is a major public health problem in tropical countries. Early diagnosis and detection are increasingly based on quantitative reverse transcriptase real-time polymerase chain reaction (RT-qPCR) directed against genomic regions conserved between different isolates. Genetic variation can however result in mismatches of primers and probes with their targeted nucleic acid regions. Read More
Zhonghua Nei Ke Za Zhi 2018 Sep;57(9):642-648
Department of Infectious Diseases, Center for Liver Diseases, Peking University First Hospital, Beijing 100034, China.
Dengue is the most prevalent and rapidly spreading mosquito-borne viral disease. As a dengue non-endemic country, China has experienced several dengue outbreaks in recent years. However, dengue patients in China displayed distinct clinical characteristics compared to patients in endemic countries. Read More
Pan Afr Med J 2017 2;28(Suppl 1). Epub 2017 Nov 2.
Paul G. Allen School for Global Animal Health, Washington State University, Pullman, WA, USA.
The recent Zika outbreak in the Americas, Ebola epidemic in West Africa and the increased frequency and impact of emerging and re-emerging infections of animal origin have increased the calls for greater preparedness in early detection and responses to public health events. One-Health approaches that emphasize collaborations between human health, animal health and environmental health sectors for the prevention, early detection and response to disease outbreaks have been hailed as a key strategy. Here we highlight three main efforts that have progressed the implementation of One Health in Kenya. Read More
BMC Infect Dis 2018 Aug 28;18(1):427. Epub 2018 Aug 28.
Consultant Obstetrician and Gynaecologist, Teaching Hospital Kandy, Kandy, Sri Lanka.
Background: Incidence of Dengue infection is on the increase in Sri Lanka with it being associated with significant maternal and neonatal morbidity in pregnancy.
Case Presentation: A 33-year-old pregnant woman at 38 weeks of gestation, presented with acute onset of fever, was later diagnosed with Dengue illness. Due to the emergence of warning symptoms and signs and rapidly dropping platelet count, the baby was delivered by urgent caesarian section. Read More
Lancet 2018 08;392(10148):623
Science 2018 08 23;361(6405):847-848. Epub 2018 Aug 23.
Sealy Institute for Vaccine Sciences and Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA.
BMC Infect Dis 2018 Aug 22;18(1):415. Epub 2018 Aug 22.
National Hospital of Sri Lanka, Colombo, Sri Lanka.
Background: Dengue infection is an endemic illness in the tropics and it is associated with a wide variety of post infectious complications. With the increasing prevalence of dengue infection in endemic regions, post-infectious neurological complications following dengue infection are now been reported more frequently. We report a patient who developed multifocal motor neuropathy (MMN) with conduction blocks following dengue infection during the immediate post-infectious period. Read More
N Engl J Med 2018 Sep 22;379(13):1198-1201. Epub 2018 Aug 22.
From the Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT (V.J.M., E.W., R.F., S.N.S.); the UK Public Health Rapid Support Team, Public Health England-London School of Hygiene and Tropical Medicine, London (D.G.B.); the University of Laval, Quebec, QC, Canada (G.K.); the Bernhard Nocht Institute for Tropical Medicine, Hamburg (C.M.-F.), the German Center for Infection Research, Hamburg (C.M.-F.), and the Institute for Tropical Medicine, University of Tübingen (F.N.) - all in Germany; the Wildlife Conservation Society, Wildlife Health Program, Bronx, NY (S.H.O.); Médecins sans Frontières, Brussels, Belgium (A.S.); the Fondation Congolaise pour la Recherche Medicale and Faculty of Sciences and Technology, University Marien Ngouabi (F.N.), and the Laboratoire National de Santé Publique, Brazzaville (J.-V.M.) - both in the Republic of the Congo; and the Ministry of Health and Social Welfare of Liberia and the Incidence Management System of Liberia, Ebola Case Management Team, Monrovia, Liberia (M.M.).
Rev Soc Bras Med Trop 2018 Jul-Aug;51(4):503-507
Pakistan Health Research Council, Research Centre, Fatima Jinnah Medical University, Lahore, Pakistan.
Introduction: Socioeconomic disparities in the community make some groups more vulnerable to dengue infection.
Methods: Fourteen dengue cases (IgM positive) served as index cases for the positive geographic cluster investigations.
Results: Of 292 individuals, the overall dengue seroprevalence was 22. Read More
Rev Inst Med Trop Sao Paulo 2018 08 20;60:e43. Epub 2018 Aug 20.
Fundação Oswaldo Cruz, Instituto Aggeu Magalhães, Departamento de Virologia e Terapia Experimental, Recife, Pernambuco, Brazil.
Indian Pediatr 2018 07;55(7):598-600
Department of Pediatrics, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India.
Proc Natl Acad Sci U S A 2018 09 20;115(36):E8378-E8387. Epub 2018 Aug 20.
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109;
Two phase 3 placebo-controlled trials of the CYD-TDV vaccine, evaluated in children aged 2-14 y (CYD14) and 9-16 y (CYD15), demonstrated vaccine efficacy (VE) of 56.5% and 60.8%, respectively, against symptomatic virologically confirmed dengue (VCD). Read More
DNA Cell Biol 2018 Oct 16;37(10):805-807. Epub 2018 Aug 16.
Regional Virology Laboratory, Department of Microbiology, All India Institute of Medical Sciences Bhopal , Bhopal, India .
Dengue is a pandemic-prone viral disease which is endemic in more than 100 countries and which puts half of the world's population at risk. While the disease presents as subclinical infection or mild fever in the majority of cases, approximately a quarter of the infected individuals experience severe forms of disease like dengue hemorrhagic fever/dengue shock syndrome that cause significant rates of mortality and morbidity. The pathogenesis of this differential outcome of infection is determined by a complex interplay of factors associated with the virus, vector, and host; much of which is not completely understood. Read More
Przegl Epidemiol 2018 ;72(2):129-141
National Institute of Public Health - National Institute of Hygiene in Warsaw, Department of Epidemiology and Surveillance
Objective Of The Article: This is for the year 2016 subsequent annual analysis of the situation of infectious and parasitic diseases in Poland as part of the Epidemiological Chronicle of the Epidemiological Review. Its purpose is to summarize the collective incidence of infectious diseases and to indicate potential threats to the health of populations from communicable diseases occurring in Poland.
Material And Methods: The basic source of epidemiological information for this summary is a summary of data from reports of the State Sanitary Inspection, contained in the annual bulletins “Infectious diseases and poisoning in Poland in 2016” and “Protective Vaccination in Poland in 2016” (1, 2). Read More
BMC Public Health 2018 Aug 14;18(1):1011. Epub 2018 Aug 14.
Ethiopian Public Health Institute, Addis Ababa, Ethiopia.
Background: Yellow fever (YF) is a viral hemorrhagic fever, endemic in the tropical forests of Africa and Central and South America. The disease is transmitted by mosquitoes infected with the yellow fever virus (YFV). Ethiopia was affected by the largest YF outbreak since the vaccination era during 1960-1962. Read More
Lancet 2018 09 10;392(10149):787-790. Epub 2018 Aug 10.
French Institute for Health and Medical Research (Inserm), Paris, France.
Pan Afr Med J 2018 25;29:227. Epub 2018 Apr 25.
Centre Pasteur Cameroon, Yaoundé, Cameroon.
To date, only a few cases of malaria and dengue co-infections have been reported around the world. We describe for the first time in Cameroon, concurrent infections among children (2 to 10 years) in two health centers of Yaoundé. The two dengue strains isolated in Cameroon clustered with the Asian II genotype. Read More
Medicine (Baltimore) 2018 Aug;97(32):e11875
Rationale: Dengue fever is a notable emerging infectious disease that is now seen worldwide, with an estimated incidence of approximately 390 million cases per year. Although ocular complications are uncommon among dengue fever-infected patients, caution is needed to prevent vision loss. Here we report a potentially serious sight-threatening complication of dengue fever, dengue fever-associated necrotizing scleritis. Read More
BMC Med 2018 08 6;16(1):129. Epub 2018 Aug 6.
Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, 12 Science Drive 2, Singapore, 117549, Singapore.
Background: Dengue, a vector-borne infectious disease caused by the dengue virus, has spread through tropical and subtropical regions of the world. All four serotypes of dengue viruses are endemic in the equatorial city state of Singapore, and frequent localised outbreaks occur, sometimes leading to national epidemics. Vector control remains the primary and most effective measure for dengue control and prevention. Read More
Lancet 2018 07 29;392(10143):213-221. Epub 2018 Jun 29.
Background: On May 8, 2018, the Government of the Democratic Republic of the Congo reported an outbreak of Ebola virus disease in Équateur Province in the northwest of the country. The remoteness of most affected communities and the involvement of an urban centre connected to the capital city and neighbouring countries makes this outbreak the most complex and high risk ever experienced by the Democratic Republic of the Congo. We provide early epidemiological information arising from the ongoing investigation of this outbreak. Read More
Lancet 2018 07 29;392(10143):189-190. Epub 2018 Jun 29.
Center for Communicable Disease Dynamics, Harvard TH Chan School of Public Health, Boston, MA 02115, USA. Electronic address:
Mem Inst Oswaldo Cruz 2018 Jul 23;113(8):e180082. Epub 2018 Jul 23.
Sanofi Pasteur, Lyon, France.
Dengue remains an unmet public health burden. We determined risk factors for dengue in-hospital mortality in Brazil. Of 326,380 hospitalised dengue cases in 9-45-year-old individuals, there were 971 deaths. Read More
Proc Natl Acad Sci U S A 2018 08 23;115(32):E7578-E7586. Epub 2018 Jul 23.
Viral-Immunobiology Laboratory, Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA 92037;
The recent Ebola epidemic exemplified the importance of understanding and controlling emerging infections. Despite the importance of T cells in clearing virus during acute infection, little is known about Ebola-specific CD8 T cell responses. We investigated immune responses of individuals infected with Ebola virus (EBOV) during the 2013-2016 West Africa epidemic in Sierra Leone, where the majority of the >28,000 EBOV disease (EVD) cases occurred. Read More
Open Forum Infect Dis 2018 Jul 16;5(7):ofy131. Epub 2018 Jul 16.
Minnesota Department of Health, St. Paul, Minnesota.
Background: In April 2014, a 46-year-old returning traveler from Liberia was transported by emergency medical services to a community hospital in Minnesota with fever and altered mental status. Twenty-four hours later, he developed gingival bleeding. Blood samples tested positive for Lassa fever RNA by reverse transcriptase polymerase chain reaction. Read More
SMU Law Rev 2018;71(2):391-444
Boston University School of Law.
Every recent presidential administration has faced an infectious disease threat, and this trend is certain to continue. The states have primary responsibility for protecting the public's health under their police powers, but modern travel makes diseases almost impossible to contain intrastate. How should the federal government respond in the future? The Ebola scare in the U. Read More
J Glob Health 2018 Dec;8(2):020601
UNICEF, New York, New York, USA.
Background: The role of community health workers (CHWs) in the West Africa Ebola outbreak has been highlighted to advocate for increasing numbers of CHWs globally to build resilience, strengthen health systems, and provide emergency response capacity. However, the roles CHWs played, the challenges they faced, and their effectiveness during the outbreak are not well documented. This study assessed the impact of Ebola on community-based maternal, newborn, and child health (MNCH) services, documented the contribution of CHWs and other community-based actors to the Ebola response, and identified lessons learned to strengthen resilience in future emergencies. Read More
Proc Natl Acad Sci U S A 2018 07 18;115(31):E7448-E7456. Epub 2018 Jul 18.
Department of Veterinary Medicine, Disease Dynamics Unit, University of Cambridge, Cambridge CB3 0ES, United Kingdom.
Vector-borne diseases (VBDs) of humans and domestic animals are a significant component of the global burden of disease and a key driver of poverty. The transmission cycles of VBDs are often strongly mediated by the ecological requirements of the vectors, resulting in complex transmission dynamics, including intermittent epidemics and an unclear link between environmental conditions and disease persistence. An important broader concern is the extent to which theoretical models are reliable at forecasting VBDs; infection dynamics can be complex, and the resulting systems are highly unstable. Read More
JAMA 2018 Jul;320(2):125-126
University Professor and Faculty Director, O'Neill Institute for National and Global Health Law, Georgetown University Law Center.
N Engl J Med 2018 Aug 11;379(7):603-605. Epub 2018 Jul 11.
From the Department of Immunization, Vaccines and Biologicals, World Health Organization, Geneva (K.V., J.H.); the London School of Hygiene and Tropical Medicine, London (A.W.-S.); and the Institute of Public Health, University of Heidelberg, Heidelberg, Germany (A.W.-S.).
PLoS Negl Trop Dis 2018 07 9;12(7):e0006598. Epub 2018 Jul 9.
Department of Chemistry, University of Copenhagen, Frederiksberg, Denmark.
Crimean-Congo hemorrhagic fever virus (CCHFV) causes severe acute human disease with lethal outcome. The knowledge about the immune response for this human health threat is highly limited. In this study, we have screened the glycoprotein of CCHFV for novel linear B-cell epitopic regions using a microarray approach. Read More
J Virol 2018 09 29;92(18). Epub 2018 Aug 29.
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA
Dengue virus is the most globally prevalent mosquito-transmitted virus. Primary infection with one of four cocirculating serotypes (DENV-1 to -4) causes a febrile illness, but secondary infection with a heterologous serotype can result in severe disease, due in part to antibody-dependent enhancement of infection (ADE). In ADE, cross-reactive but nonneutralizing antibodies, or subprotective levels of neutralizing antibodies, promote uptake of antibody-opsonized virus in Fc-γ receptor-positive cells. Read More
Rev Soc Bras Med Trop 2018 May-Jun;51(3):347-351
Secretaria Municipal de Saúde do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.
Introduction: Dengue has affected Rio de Janeiro City since the 1980s. The sequential Zika and chikungunya virus introductions during 2015 aggravated the health scenario, with 97,241 cases of arboviral diseases reported in 2015-2016, some with neurological disorders.
Methods: Arbovirus-related neurologic cases were descriptively analyzed, including neurological syndromes and laboratory results. Read More
Lancet 2018 07 26;392(10144):279-280. Epub 2018 Jun 26.
National Public Health Institute of Liberia, Monrovia, Liberia.
PLoS Negl Trop Dis 2018 06 28;12(6):e0006616. Epub 2018 Jun 28.
Sanofi Pasteur, Asia & JPAC Region, Singapore.
Background: Dengue is a febrile illness transmitted by mosquitoes, causing disease across the tropical and sub-tropical world. Antibody prevalence data and serotype distributions describe population-level risk and inform public health decision-making.
Methodology/principal Findings: In this cross-sectional study we used data from a pediatric dengue seroprevalence study to describe historical dengue serotype circulation, according to age and geographic location. Read More
PLoS Negl Trop Dis 2018 06 27;12(6):e0006604. Epub 2018 Jun 27.
Guangzhou Center for Disease Control and Prevention, Guangzhou, Guangdong province, China.
Background: The epidemic tendency of hemorrhagic fever with renal syndrome (HFRS) is on the rise in recent years in Guangzhou. This study aimed to explore the associations between meteorological factors and HFRS epidemic risk in Guangzhou for the period from 2006-2015.
Methods: We obtained data of HFRS cases in Guangzhou from the National Notifiable Disease Report System (NNDRS) during the period of 2006-2015. Read More
Mem Inst Oswaldo Cruz 2018 Jun 25;113(8):e180036. Epub 2018 Jun 25.
Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Flavivírus, Rio de Janeiro, RJ, Brasil.
The dengue virus (DENV), of the genus Flavivirus (Flaviviridae), has four antigenically distinct serotypes, of which DENV-3 is classified into five genotypes. Here, we describe the detection of DENV-3 genotype I in sera of a Brazilian patient travelling from Singapore to Rio de Janeiro, Brazil, by using multiplex real-time RT-PCR, DNA sequencing of the whole envelope protein gene, and phylogenetic analysis. The virus shares ancestry with those identified in Bali, Indonesia, in 2015. Read More
Mem Inst Oswaldo Cruz 2018 Jun 25;113(8):e170433. Epub 2018 Jun 25.
Universidade de Brasília, Núcleo de Medicina Tropical, Brasília, DF, Brasil.
Background: The diagnosis of dengue is complex. Until recently, only specialised laboratories were able to confirm dengue infection. However, this has changed with the newly available immunochromatographic rapid tests. Read More
Proc Natl Acad Sci U S A 2018 07 26;115(28):E6604-E6613. Epub 2018 Jun 26.
Department of Biological Sciences, Old Dominion University, Norfolk, VA 23529;
Dengue virus (DENV) is a mosquito-borne flavivirus that causes dengue fever in humans, worldwide. Using in vitro cell lines derived from and , the primary vectors of DENV, we report that DENV2/DENV3-infected cells secrete extracellular vesicles (EVs), including exosomes, containing infectious viral RNA and proteins. A full-length DENV2 genome, detected in arthropod EVs, was infectious to naïve mosquito and mammalian cells, including human-skin keratinocytes and blood endothelial cells. Read More
Travel Med Infect Dis 2018 Jul - Aug;24:13-14. Epub 2018 Jun 23.
Public Health and Infection Research and Incubator Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia; Medical School, Universidad Franz Tamayo/UNIFRANZ, Bolivia. Electronic address:
Indian J Ophthalmol 2018 07;66(7):1017-1019
Department of Molecular Microbioloy, Sankara Nethralaya Referral Laboratory, Chennai, Tamil Nadu, India.
Dengue fever, a mosquito-borne disease commonly found in the tropics, is one of the most prevalent forms of Flavivirus infection in humans. Symptomatically, it is characterized by fever, arthralgia, headache, and rash. Ophthalmic manifestations can involve both the anterior and posterior segment. Read More
Proc Natl Acad Sci U S A 2018 07 25;115(28):7410-7415. Epub 2018 Jun 25.
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;
The 2014 western Africa Ebola virus (EBOV) epidemic was unprecedented in magnitude, infecting over 28,000 and causing over 11,000 deaths. During this outbreak, multiple instances of EBOV sexual transmission were reported, including cases where the infectious individual had recovered from EBOV disease months before transmission. Potential human host factors in EBOV sexual transmission remain unstudied. Read More
PLoS Negl Trop Dis 2018 06 25;12(6):e0006570. Epub 2018 Jun 25.
Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA.
Background: Historically, mosquito control programs successfully helped contain malaria and yellow fever, but recent efforts have been unable to halt the spread of dengue, chikungunya, or Zika, all transmitted by Aedes mosquitoes. Using a dengue transmission model and results from indoor residual spraying (IRS) field experiments, we investigated how IRS-like campaign scenarios could effectively control dengue in an endemic setting.
Methods And Findings: In our model, we found that high levels of household coverage (75% treated once per year), applied proactively before the typical dengue season could reduce symptomatic infections by 89. Read More
BMC Res Notes 2018 Jun 20;11(1):400. Epub 2018 Jun 20.
Department of Medicine, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka.
Objective: This retrospective study was conducted in 2017 with the objective of evaluating the value of acute phase peripheral blood parameters in predicting dengue haemorrhagic fever (DHF). Patients, who were admitted to Teaching Hospital Peradeniya between January and August 2017 due to dengue illness, were recruited into this study.
Results: A total of 515 patients participated in the study. Read More