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    24043 results match your criteria Viral Hemorrhagic Fevers

    1 OF 481

    Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses.
    Nat Commun 2018 May 14;9(1):1884. Epub 2018 May 14.
    Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, 02115, USA.
    While five arenaviruses cause human hemorrhagic fevers in the Western Hemisphere, only Junin virus (JUNV) has a vaccine. The GP1 subunit of their envelope glycoprotein binds transferrin receptor 1 (TfR1) using a surface that substantially varies in sequence among the viruses. As such, receptor-mimicking antibodies described to date are type-specific and lack the usual breadth associated with this mode of neutralization. Read More

    Acute Viral Hepatitis: Beyond A, B, and C.
    Surg Pathol Clin 2018 Jun 26;11(2):251-266. Epub 2018 Mar 26.
    Department of Pathology, Surgical Pathology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil. Electronic address:
    From the standpoint of the surgical pathologist "hepatitis" is defined as the set of histologic patterns of lesions found in livers infected by hepatotropic viruses, by non-hepatotrophic viruses leading to liver inflammation in the context of systemic infection, or due to an autoimmune disease, drug, or toxin involving the liver. This article is centered on the histologic patterns of injury in acute viral hepatitis, encompassing the hepatotropic viruses A, B, C, D, and E and the "icteric hemorrhagic fevers" (dengue, hantavirus, yellow fever). A brief mention of viruses causing hepatitis in immunosuppressed patients also is presented. Read More

    Vital Signs: Trends in Reported Vectorborne Disease Cases - United States and Territories, 2004-2016.
    MMWR Morb Mortal Wkly Rep 2018 May 4;67(17):496-501. Epub 2018 May 4.
    Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, CDC, Fort Collins, Colorado.
    Introduction: Vectorborne diseases are major causes of death and illness worldwide. In the United States, the most common vectorborne pathogens are transmitted by ticks or mosquitoes, including those causing Lyme disease; Rocky Mountain spotted fever; and West Nile, dengue, and Zika virus diseases. This report examines trends in occurrence of nationally reportable vectorborne diseases during 2004-2016. Read More

    Antibodies to the Glycoprotein GP2 Subunit Cross-React between Old and New World Arenaviruses.
    mSphere 2018 Jun 2;3(3). Epub 2018 May 2.
    Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
    Arenaviruses pose a major public health threat and cause numerous infections in humans each year. Although most viruses belonging to this family do not cause disease in humans, some arenaviruses, such as Lassa virus and Machupo virus, are the etiological agents of lethal hemorrhagic fevers. The absence of a currently licensed vaccine and the highly pathogenic nature of these viruses both make the necessity of developing viable vaccines and therapeutics all the more urgent. Read More

    Multisectoral prioritization of zoonotic diseases in Uganda, 2017: A One Health perspective.
    PLoS One 2018 1;13(5):e0196799. Epub 2018 May 1.
    United States Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.
    Background: Zoonotic diseases continue to be a public health burden globally. Uganda is especially vulnerable due to its location, biodiversity, and population. Given these concerns, the Ugandan government in collaboration with the Global Health Security Agenda conducted a One Health Zoonotic Disease Prioritization Workshop to identify zoonotic diseases of greatest national concern to the Ugandan government. Read More

    Novel Insights into Cell Entry of Emerging Human Pathogenic Arenaviruses.
    J Mol Biol 2018 Apr 26. Epub 2018 Apr 26.
    Institute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Electronic address:
    Viral hemorrhagic fevers (VHF) caused by emerging RNA viruses of the Arenavirus family are among the most devastating human diseases. Climate change, global trade, and increasing urbanization promote the emergence and re-emergence of these human pathogenic viruses. Emerging pathogenic arenaviruses are of zoonotic origin and reservoir-to-human transmission is crucial for spillover into human populations. Read More

    The Asian tiger mosquito, Aedes (Stegomyia) albopictus (Skuse), a vector of dengue, chikungunya and zika viruses, reaches Portugal (Diptera: Culicidae).
    Zootaxa 2018 Apr 20;4413(1):197-200. Epub 2018 Apr 20.
    Computational Biology and Population Genomics Group, cE3c - Centre for Ecology, Evolution and Environmental Changes, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal..
    The Asian tiger mosquito, Aedes (Stegomyia) albopictus (Skuse), is a tropical species originally from south-eastern Asia (Hawley, 1988). It has experienced a rampant human-mediated range expansion since the 1970s to now occupy almost the whole of the tropical and subtropical areas of the world. As an eclectic haematophagous species, it attacks humans and is able to use a number of man-made and natural structures where stagnant water is present (Estrada-Franco Craig, 1995). Read More

    Alkhurma Hemorrhagic Fever Virus RNA in Hyalomma rufipes Ticks Infesting Migratory Birds, Europe and Asia Minor.
    Emerg Infect Dis 2018 May;24(5):879-882
    Alkhurma hemorrhagic fever virus RNA was detected in immature Hyalomma rufipes ticks infesting northward migratory birds caught in the North Mediterranean Basin. This finding suggests a role for birds in the ecology of the Alkhurma hemorrhagic fever virus and a potential mechanism for dissemination to novel regions. Increased surveillance is warranted. Read More

    Southeast Asian J Trop Med Public Health 2017 Mar;48(2):297-305
    The aim of this study was to study the relationships between economic status, knowledge, attitude and practice regarding dengue fever (DF), attitude towards vaccination against dengue virus infection, willingness to participate in a study on dengue, and acceptance of a dengue vaccine. Information on variables of interest was collected in questionnaire-assisted interviews during a communitybased cross-sectional survey conducted in Aceh, Indonesia. A proposed relationship model was tested using Confirmatory Factor Analysis (CFA), and an Exploratory Factor Analysis (EFA) was used to reconstruct an alternative relationship model among variables. Read More

    Yellow fever.
    Rev Assoc Med Bras (1992) 2018 Feb;64(2):106-113
    Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
    The yellow fever (YF) virus is a Flavivirus, transmitted by Haemagogus, Sabethes or Aedes aegypti mosquitoes. The disease is endemic in forest areas in Africa and Latin America leading to epizootics in monkeys that constitute the reservoir of the disease. There are two forms of YF: sylvatic, transmitted accidentally when approaching the forests, and urban, which can be perpetuated by Aedes aegypti. Read More

    Taxonomy of the order Mononegavirales: update 2018.
    Arch Virol 2018 Apr 11. Epub 2018 Apr 11.
    Integrated Research Facility at Fort Detrick (IRF-Frederick), Division of Clinical Research (DCR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), B-8200 Research Plaza, Fort Detrick, Frederick, MD, 21702, USA.
    In 2018, the order Mononegavirales was expanded by inclusion of 1 new genus and 12 novel species. This article presents the updated taxonomy of the order Mononegavirales as now accepted by the International Committee on Taxonomy of Viruses (ICTV) and summarizes additional taxonomic proposals that may affect the order in the near future. Read More

    Rapid Diagnostic Tests in Childhood Infections.
    Indian Pediatr 2018 03;55(3):233-237
    Department of Pediatrics, Institute of Child Health, Kolkata, India.
    Presumptive treatment of infections often results in irrational antimicrobial use resulting in detrimental spread of drug resistance and untoward side effects. A rapid diagnostic test (RDT) is a test that delivers a result earlier than conventional testing methods employed in the past to identify the offending microorganism. RDTs help in early definitive therapy, reduction in hospital stay and cost, and in degree of morbidity and mortality associated with the infection. Read More

    Risk factors for hematemesis in Hoima and Buliisa Districts, Western Uganda, September-October 2015.
    Pan Afr Med J 2017 8;28:215. Epub 2017 Nov 8.
    US Centers for Disease Control and Prevention, Kampala, Uganda.
    Introduction: On 17 September 2015, Buliisa District Health Office reported multiple deaths due to haemorrhage to the Uganda Ministry of Health. We conducted an investigation to verify the existence of an outbreak and to identify the disease nature, mode of transmission and risk factors.

    Methods: We defined a suspected case as onset of hematemesis between 1 June 2015 and 15 October 2015 in a resident of Hoima, Buliisa or neighbouring districts. Read More

    Anthropology in public health emergencies:
    BMJ Glob Health 2018 25;3(2):e000534. Epub 2018 Mar 25.
    Médecins Sans Frontières, London, UK.
    Recent outbreaks of Ebola virus disease (2013-2016) and Zika virus (2015-2016) bring renewed recognition of the need to understand social pathways of disease transmission and barriers to care. Social scientists, anthropologists in particular, have been recognised as important players in disease outbreak response because of their ability to assess social, economic and political factors in local contexts. However, in emergency public health response, as with any interdisciplinary setting, different professions may disagree over methods, ethics and the nature of evidence itself. Read More

    Impact of Ebola experiences and risk perceptions on mental health in Sierra Leone, July 2015.
    BMJ Glob Health 2018 17;3(2):e000471. Epub 2018 Mar 17.
    Division of Global Health Protection, Centers for Global Health, US Centers for Disease Control and Prevention (CDC), Atlanta, Georgia, USA.
    Background: The mental health impact of the 2014-2016 Ebola epidemic has been described among survivors, family members and healthcare workers, but little is known about its impact on the general population of affected countries. We assessed symptoms of anxiety, depression and post-traumatic stress disorder (PTSD) in the general population in Sierra Leone after over a year of outbreak response.

    Methods: We administered a cross-sectional survey in July 2015 to a national sample of 3564 consenting participants selected through multistaged cluster sampling. Read More

    Global Aspects of Viral Glycosylation Enveloped viruses/herpesvirus/mass spectrometry/mucin type O-glycosylation/viral glycans.
    Glycobiology 2018 Mar 22. Epub 2018 Mar 22.
    Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, University of Copenhagen, 2200 Copenhagen N, Denmark.
    Enveloped viruses encompass some of the most common human pathogens causing infections of different severity, ranging from no or very few symptoms to lethal disease as seen with the viral hemorrhagic fevers. All enveloped viruses possess an envelope membrane derived from the host cell, modified with often heavily glycosylated virally encoded glycoproteins important for infectivity, viral particle formation, and immune evasion. While N-linked glycosylation of viral envelope proteins is well characterized with respect to location, structure, and site occupancy, information on mucin-type O-glycosylation of these proteins is less comprehensive. Read More

    Fatal Yellow Fever in Travelers to Brazil, 2018.
    MMWR Morb Mortal Wkly Rep 2018 Mar 23;67(11):340-341. Epub 2018 Mar 23.
    Yellow fever virus is a mosquito-borne flavivirus that causes yellow fever, an acute infectious disease that occurs in South America and sub-Saharan Africa. Most patients with yellow fever are asymptomatic, but among the 15% who develop severe illness, the case fatality rate is 20%-60%. Effective live-attenuated virus vaccines are available that protect against yellow fever (1). Read More

    Cardiovascular disease and yellow fever.
    Rev Assoc Med Bras (1992) 2018 01;64(1):1-2
    MD, Assistant Physician and Preceptor in the Unit of Coronary Artery Disease of the Pronto-Socorro Cardiológico Universitário de Pernambuco (Procape - UPE). Coordinator of the Coronary Artery Disease Unit at Real Hospital Português de Beneficência em Pernambuco, Recife, PE, Brazil.

    Synthesis and characterization of nitrile functionalized silver(I)-N-heterocyclic carbene complexes: DNA binding, cleavage studies, antibacterial properties and mosquitocidal activity against the dengue vector, Aedes albopictus.
    Eur J Med Chem 2018 Apr 13;150:601-615. Epub 2018 Mar 13.
    Molecular Entomology Research Group, School of Distance Education, Universiti Sains Malaysia, 11800 USM, Penang, Malaysia.
    A series of four benzimidazolium based nitrile-functionalized mononuclear-Ag(I)-N-heterocyclic carbene and binuclear-Ag(I)-N-heterocyclic carbene (Ag(I)-NHC) hexafluorophosphate complexes (5b-8b) were synthesized by reacting the corresponding hexafluorophosphate salts (1b-4b) with AgO in acetonitrile, respectively. These compounds were characterized by H NMR, C NMR, IR, UV-visible spectroscopic techniques, elemental analyses and molar conductivity. Additionally, 8b was structurally characterized by single crystal X-ray diffraction technique. Read More

    Taraxacum officinale and Urtica dioica extracts inhibit dengue virus serotype 2 replication in vitro.
    BMC Complement Altern Med 2018 Mar 16;18(1):95. Epub 2018 Mar 16.
    Laboratorio de Biología Molecular y Virología, Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Km 4.5 Carr Federal Atlixco-Metepec, 74360, Metepec, Puebla, México.
    Background: Urtica dioica, Taraxacum officinale, Calea integrifolia and Caesalpinia pulcherrima are widely used all over the world for treatment of different illnesses. In Mexico, these plants are traditionally used to alleviate or counteract rheumatism and inflammatory muscle diseases. In the present study we evaluated the activity of aqueous and methanolic extracts of these four plants, on the replication of dengue virus serotype 2 (DENV2). Read More

    Human Papillomavirus Type 16 Integration Analysis by Real-time PCR Assay in Associated Cancers.
    Transl Oncol 2018 Mar 13;11(3):593-598. Epub 2018 Mar 13.
    Department of Virology, Iran University of Medical Sciences, Tehran, Iran.
    Human papillomavirus (HPV) is a common viral infection worldwide associated with a variety of cancers. The integration of the HPV genome in these patients causes chromosomal instability and triggers carcinogenesis. The aim of this study was to investigate the HPV-16 genome physical status in four major cancers related to HPV infection. Read More

    Risk perception and level of knowledge of diseases transmitted by Aedes aegypti.
    Rev Inst Med Trop Sao Paulo 2018 Mar 8;60:e10. Epub 2018 Mar 8.
    Servicios de Salud de Hidalgo, Coordinación de Investigación en Salud, Pachuca, Hidalgo, México.
    Diseases caused by viruses such as dengue, chikungunya and zika are mosquito-borne diseases transmitted by Aedes aegypti. We performed a cross-sectional study of healthcare personnel and the general population using questionnaires to identify the level of knowledge, attitudes and practices, and risk perception for dengue, chikungunya and zika. A total of 248 questionnaires were applied, 63. Read More

    Successes and failures of sixty years of vector control in French Guiana: what is the next step?
    Mem Inst Oswaldo Cruz 2018 Mar 12;113(5):e170398. Epub 2018 Mar 12.
    Institut Pasteur de la Guyane, Unit Vector Adaptation and Control, Vectopôle Amazonien Emile Abonnenc, Cayenne, French Guiana.
    Since the 1940s, French Guiana has implemented vector control to contain or eliminate malaria, yellow fever, and, recently, dengue, chikungunya, and Zika. Over time, strategies have evolved depending on the location, efficacy of the methods, development of insecticide resistance, and advances in vector control techniques. This review summarises the history of vector control in French Guiana by reporting the records found in the private archives of the Institute Pasteur in French Guiana and those accessible in libraries worldwide. Read More

    Human T Lymphocytes Are Permissive for Dengue Virus Replication.
    J Virol 2018 05 27;92(10). Epub 2018 Apr 27.
    Laboratório de Virologia Molecular, Instituto Carlos Chagas, ICC/Fiocruz-PR, Curitiba, Paraná, Brazil
    Dengue virus (DV) infection can cause either a self-limiting flu-like disease or a threatening hemorrhage that may evolve to shock and death. A variety of cell types, such as dendritic cells, monocytes, and B cells, can be infected by DV. However, despite the role of T lymphocytes in the control of DV replication, there remains a paucity of information on possible DV-T cell interactions during the disease course. Read More

    Building Infestation Index for Aedes aegypti and occurrence of dengue fever in the municipality of Foz do Iguaçu, Paraná, Brazil, from 2001 to 2016.
    Rev Soc Bras Med Trop 2018 Jan-Feb;51(1):71-76
    Programa de Doutorado em Ciências Animais com ênfase em produtos Bioativos da Universidade Paranaense, Umuarama, PR, Brasil.
    Introduction: the Building Infestation Index (BII) uses the Rapid Assay of the Larval Index for Aedes aegypti (LIRAa) to express the relationship between positive and surveyed properties. We evaluated LIRAa and the relationship between the BII and climate variables for dengue cases in Foz do Iguaçu municipality, Paraná.

    Methods: Spearman's correlations for mean precipitation, mean temperature, BII, and dengue cases (time lag). Read More

    Development and characterization of a guinea pig model for Marburg virus.
    Zool Res 2018 Jan;39(1):32-41
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada.
    The Angolan strain of Marburg virus (MARV/Ang) can cause lethal disease in humans with a case fatality rate of up to 90%, but infection of immunocompetent rodents do not result in any observable symptoms. Our previous work includes the development and characterization of a MARV/Ang variant that can cause lethal disease in mice (MARV/Ang-MA), with the aim of using this tool to screen for promising prophylactic and therapeutic candidates. An intermediate animal model is needed to confirm any findings from mice studies before testing in the gold-standard non-human primate (NHP) model. Read More

    Animal models for filovirus infections.
    Zool Res 2018 Jan;39(1):15-24
    Special Pathogens Program, Public Health Agency of Canada, Winnipeg, Manitoba R3E 3R2, Canada.
    The family , which includes the genera and , contains some of the most pathogenic viruses in humans and non-human primates (NHPs), causing severe hemorrhagic fevers with high fatality rates. Small animal models against filoviruses using mice, guinea pigs, hamsters, and ferrets have been developed with the goal of screening candidate vaccines and antivirals, before testing in the gold standard NHP models. In this review, we summarize the different animal models used to understand filovirus pathogenesis, and discuss the advantages and disadvantages of each model with respect to filovirus disease research. Read More

    The protective effect and diagnostic performance of NOX-5 in Crimean-Congo haemorrhagic fever patients.
    J Med Microbiol 2018 Apr 6;67(4):543-548. Epub 2018 Mar 6.
    1​Department of Infectious Disease and Clinical Microbiology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
    Introduction: Crimean-Congo haemorrhagic fever (CCHF) is an acute viral haemorrhagic disease. Reactive oxygen species that are mainly generated by the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) enzyme family have a pivotal role in the pathophysiology of many diseases. The serum levels of NOX isoforms in patients with CCHF have yet to be assessed. Read More

    Hemorrhagic fever with renal syndrome accompanied by panhypopituitarism and central diabetes insipidus: a case report.
    J Neurovirol 2018 Mar 5. Epub 2018 Mar 5.
    Premedical Science, College of Medicine, Chosun University, Gwangju, Republic of Korea.
    Central diabetes insipidus (DI) was detected in a patient with hemorrhagic fever with renal syndrome (HFRS) who had been molecularly and serologically diagnosed with Hantaan virus infection. We recommend that clinicians differentiate central DI in HFRS patients with a persistent diuretic phase even when pituitary MRI findings are normal. Read More

    Dengue Virus and Its Inhibitors: A Brief Review.
    Chem Pharm Bull (Tokyo) 2018 ;66(3):191-206
    Graduate School of Pharmaceutical Sciences, Osaka University.
    The global occurrence of viral infectious diseases poses a significant threat to human health. Dengue virus (DENV) infection is one of the most noteworthy of these infections. According to a WHO survey, approximately 400 million people are infected annually; symptoms deteriorate in approximately one percent of cases. Read More

    Dengue in Araraquara, state of São Paulo: epidemiology, climate and Aedes aegypti infestation.
    Rev Saude Publica 2018 26;52:18. Epub 2018 Feb 26.
    Departamento de Ciências Biológicas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista "Júlio de Mesquita Filho", Araraquara, SP, Brasil.
    OBJECTIVE To describe the epidemiology of dengue in a medium-sized city in the state of São Paulo. METHODS Data, such as circulating serotypes, severe cases and deaths, age group, sex, among others, were obtained on reported and confirmed dengue cases in Araraquara, state of São Paulo, between 1991 and 2015. Climatic and infestation data were also analyzed. Read More

    Infection prevention and control training and capacity building during the Ebola epidemic in Guinea.
    PLoS One 2018 28;13(2):e0193291. Epub 2018 Feb 28.
    Guinea Ministry of Health and Public Hygiene, Conakry, Guinea.
    Background: During the 2014-2016 Ebola epidemic in West Africa, a key epidemiological feature was disease transmission within healthcare facilities, indicating a need for infection prevention and control (IPC) training and support.

    Methods: IPC training was provided to frontline healthcare workers (HCW) in healthcare facilities that were not Ebola treatment units, as well as to IPC trainers and IPC supervisors placed in healthcare facilities. Trainings included both didactic and hands-on components, and were assessed using pre-tests, post-tests and practical evaluations. Read More

    The Ebola-effect in Guinea 2014-15: Tangled trends of malaria care in children under-five.
    PLoS One 2018 28;13(2):e0192798. Epub 2018 Feb 28.
    Médecins sans Frontières, Medical Department (Operational Research), Operational Centre Brussels, Luxembourg, Luxembourg.
    Introduction: The 2014-15 Ebola outbreak in West Africa was disruptive for the general health services in the affected countries. This study assessed the impact of the outbreak on the reported number and management of malaria in children under-five in rural Guinea.

    Materials And Methods: A retrospective cross-sectional study was conducted in nineteen health centres in two rural, malaria-endemic health districts, one at the epicentre of the outbreak (Guéckédou) and one (Koubia) spared by Ebola. Read More

    [Dengue in a newborn].
    Rev Chilena Infectol 2017 Oct;34(5):494-498
    Facultad de Medicina, Universidad Nacional Hermilio Valdizán, Valdizán, Perú.
    Dengue is the disease transmitted by arthropods of major importance in public health; however its presence in the neonatal stage is poorly studied, with few cases described worldwide. We present the case report of a neonate who started illness at 12 days of age, characterized by fever and irritability. He was hospitalized for suspicion of neonatal sepsis; later he presented thrombocytopenia and due the antecedent of his mother with diagnosis of dengue after childbirth, dengue tests were obtained in the neonate, resulting positive, then support treatment and fluid treatment is performed, with subsequent recovery. Read More

    Concurrent methicillin-resistant Staphylococcus aureus septicemia and pyomyositis in a patient with dengue hemorrhagic fever: a case report.
    BMC Infect Dis 2018 02 27;18(1):99. Epub 2018 Feb 27.
    The Teaching (General) Hospital - Kandy, Kandy, Sri Lanka.
    Background: Concurrent presence of dengue hemorrhagic fever (DHF), tropical pyomyositis and septicemia due to methicillin-resistant Staphylococcus aureus (MRSA) in a previously healthy person has never been reported. These three conditions even individually are potentially fatal. "Here we describe a case of a patient contracting dengue and developing DHF along with concurrent pyomyositis likely to be due to MRSA, leading to MRSA septicemia with abscesses formed by MRSA". Read More

    Knowledge, attitude, and practice regarding dengue virus infection among inhabitants of Aceh, Indonesia: a cross-sectional study.
    BMC Infect Dis 2018 02 27;18(1):96. Epub 2018 Feb 27.
    Institute of Occupational Medicine, Social Medicine and Environmental Medicine, Goethe University, Frankfurt am Main, Germany.
    Background: The Indonesian region of Aceh was the area most severely affected by the earthquake and tsunami of 26 December 2004. Department of Health data reveal an upward trend of dengue cases in Aceh since the events of the tsunami. Despite the increasing incidence of dengue in the region, there is limited understanding of dengue among the general population of Aceh. Read More

    Short-term renal outcomes following acute kidney injury among dengue patients: A follow-up analysis from large prospective cohort.
    PLoS One 2018 26;13(2):e0192510. Epub 2018 Feb 26.
    School of Pharmacy, Monash University Malaysia, Bandar Sunway, Malaysia.
    Background: Despite myriad improvements in the care of dengue patients, acute kidney injury (AKI) remained least appreciated intricacy of dengue infection. Exiting literature does not provide any information on renal outcomes among dengue patients surviving an episode of AKI.

    Methods: Dengue patients who developed AKI were followed up for post-discharge period of three months and renal recovery was assessed by using recovery criteria based on different thresholds of serum creatinine (SCr) and estimated glomerular filtration rates (eGFR). Read More

    Factors determining dengue outbreak in Malaysia.
    PLoS One 2018 23;13(2):e0193326. Epub 2018 Feb 23.
    Medical Entomology Unit & WHO Collaborating Centre for Vectors, Institute for Medical Research, Kuala Lumpur, Malaysia.
    A large scale study was conducted to elucidate the true relationship among entomological, epidemiological and environmental factors that contributed to dengue outbreak in Malaysia. Two large areas (Selayang and Bandar Baru Bangi) were selected in this study based on five consecutive years of high dengue cases. Entomological data were collected using ovitraps where the number of larvae was used to reflect Aedes mosquito population size; followed by RT-PCR screening to detect and serotype dengue virus in mosquitoes. Read More

    Dengue score as a diagnostic predictor for pleural effusion and/or ascites: external validation and clinical application.
    BMC Infect Dis 2018 02 23;18(1):90. Epub 2018 Feb 23.
    Department of Clinical Pathology, Pondok Indah Hospital, Jakarta, Indonesia.
    Background: The Dengue Score is a model for predicting pleural effusion and/or ascites and uses the hematocrit (Hct), albumin concentration, platelet count and aspartate aminotransferase (AST) ratio as independent variables. As this metric has not been validated, we conducted a study to validate the Dengue Score and assess its clinical application.

    Methods: A retrospective study was performed at a private hospital in Jakarta, Indonesia. Read More

    Seroprevalence of dengue IgG antibodies in symptomatic and asymptomatic individuals three years after an outbreak in Zhejiang Province, China.
    BMC Infect Dis 2018 02 23;18(1):92. Epub 2018 Feb 23.
    Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
    Background: Cross-reacting antibodies enhanced dengue infection in humans and antibody dependent enhancement (ADE) have been proposed as early mechanisms underlying DHF/DSS. However, the duration of dengue IgG antibodies in the body as well as factors associated with said duration remain unclear.

    Methods: Blood samples from 59 dengue symptomatic persons and 48 asymptomatic individuals were collected. Read More

    Glutathionylation of dengue and Zika NS5 proteins affects guanylyltransferase and RNA dependent RNA polymerase activities.
    PLoS One 2018 22;13(2):e0193133. Epub 2018 Feb 22.
    Institute of Molecular Biosciences, Mahidol University, Salaya Campus, Salaya, Thailand.
    It has been estimated for dengue infection that the global population at risk is 3.5 billion people, which makes dengue an important public health problem. The causative agents of dengue are dengue viruses. Read More

    Socio-economic, Knowledge Attitude Practices (KAP), household related and demographic based appearance of non-dengue infected individuals in high dengue risk areas of Kandy District, Sri Lanka.
    BMC Infect Dis 2018 02 21;18(1):88. Epub 2018 Feb 21.
    Department of Paraclinical Science, Faculty of Medicine, Sir John Kotelawala Defense University, Ratmalana, Sri Lanka.
    Background: Socio-economic, demographic factors and Knowledge Attitude Practices (KAPs) have been recognized as critical factors that influence the incidence and transmission of dengue epidemics. However, studies that characterize above features of a risk free or low risk population are rare. Therefore, the present study was conducted to characterize the household related, demographic, socio-economic factors and KAPs status of five selected dengue free communities. Read More

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