31,820 results match your criteria Viral Encephalitis


Recent Progress on Functional Genomics Research of Enterovirus 71.

Virol Sin 2018 Dec 14. Epub 2018 Dec 14.

Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.

Enterovirus 71 (EV71) is one of the main pathogens that causes hand-foot-and-mouth disease (HFMD). HFMD caused by EV71 infection is mostly self-limited; however, some infections can cause severe neurological diseases, such as aseptic meningitis, brain stem encephalitis, and even death. There are still no effective clinical drugs used for the prevention and treatment of HFMD. Read More

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http://link.springer.com/10.1007/s12250-018-0071-9
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http://dx.doi.org/10.1007/s12250-018-0071-9DOI Listing
December 2018
1 Read

The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions.

Authors:
Po-Yuan Ke

Int J Mol Sci 2018 Dec 7;19(12). Epub 2018 Dec 7.

Department of Biochemistry & Molecular Biology and Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan.

Autophagy is an evolutionarily conserved cellular process in which intracellular components are eliminated via lysosomal degradation to supply nutrients for organelle biogenesis and metabolic homeostasis. Flavivirus infections underlie multiple human diseases and thus exert an immense burden on public health worldwide. Mounting evidence indicates that host autophagy is subverted to modulate the life cycles of flaviviruses, such as hepatitis C virus, dengue virus, Japanese encephalitis virus, West Nile virus and Zika virus. Read More

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http://dx.doi.org/10.3390/ijms19123940DOI Listing
December 2018
1 Read

Japanese Encephalitis Virus NS1' Protein Antagonizes Interferon Beta Production.

Virol Sin 2018 Dec 12. Epub 2018 Dec 12.

State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.

Japanese encephalitis virus (JEV) is a mosquito-borne virus and the major cause of viral encephalitis in Asia. NS1', a 52-amino acid C-terminal extension of NS1, is generated with a -1 programmed ribosomal frameshift and is only present in members of the Japanese encephalitis serogroup of flaviviruses. Previous studies demonstrated that NS1' plays a vital role in virulence, but the mechanism is unclear. Read More

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http://dx.doi.org/10.1007/s12250-018-0067-5DOI Listing
December 2018
1 Read

Prognostic evaluation of child patients with infectious encephalitis through AEEG and REEG.

Exp Ther Med 2018 Dec 19;16(6):5243-5247. Epub 2018 Oct 19.

Department of Internal Medicine, Weifang People's Hospital, Weifang, Shandong 261000, P.R. China.

This study investigated prognostic evaluation of child patients with viral encephalitis through ambulatory electroencephalogram (AEEG) and regular electroencephalogram (REEG). A total of 94 child patients who were clinically diagnosed with viral encephalitis in Yantaishan Hospital of Yantai from May 2010 to July 2014, was examined with AEEG and REEG, respectively and randomly divided into AEEG group (n=47) and REEG group (n=47). The probabilities of detecting abnormal electroencephalographic activities with two examination methods were compared. Read More

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http://dx.doi.org/10.3892/etm.2018.6882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257196PMC
December 2018

Tick-Borne Flaviviruses, with a Focus on Powassan Virus.

Clin Microbiol Rev 2019 Jan 12;32(1). Epub 2018 Dec 12.

Institute for Veterinary Medical Research, Centre for Agricultural Research, Hungarian Academy of Sciences, Budapest, Hungary

SUMMARYThe tick-borne pathogen Powassan virus is a rare cause of encephalitis in North America and the Russian Far East. The number of documented cases described since the discovery of Powassan virus in 1958 may be <150, although detection of cases has increased over the past decade. In the United States, the incidence of Powassan virus infections expanded from the estimated 1 case per year prior to 2005 to 10 cases per year during the subsequent decade. Read More

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http://cmr.asm.org/lookup/doi/10.1128/CMR.00106-17
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http://dx.doi.org/10.1128/CMR.00106-17DOI Listing
January 2019
1 Read

Loss of Transfected Human Brain Micro-Vascular Endothelial Cell Integrity during Herpes Simplex Virus Infection.

Intervirology 2018 Dec 12:1-11. Epub 2018 Dec 12.

Faculty of Medicine and Biomedical Sciences, MAHSA University, Saujana Putra Campus, Jenjarum,

Objective: Herpes simplex virus infection through the neuronal route is the most well-studied mode of viral encephalitis that can persists in a human host for a lifetime. However, the involvement of other possible infection mechanisms by the virus remains underexplored. Therefore, this study aims to determine the temporal effects and mechanisms by which the virus breaches the human brain micro-vascular endothelial cells of the blood-brain barrier. Read More

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http://dx.doi.org/10.1159/000495180DOI Listing
December 2018

Cryo-EM Structures of Eastern Equine Encephalitis Virus Reveal Mechanisms of Virus Disassembly and Antibody Neutralization.

Cell Rep 2018 Dec;25(11):3136-3147.e5

Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA. Electronic address:

Alphaviruses are enveloped pathogens that cause arthritis and encephalitis. Here, we report a 4.4-Å cryoelectron microscopy (cryo-EM) structure of eastern equine encephalitis virus (EEEV), an alphavirus that causes fatal encephalitis in humans. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183184
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http://dx.doi.org/10.1016/j.celrep.2018.11.067DOI Listing
December 2018
8 Reads

Importance of cerebrospinal fluid investigation during dengue infection in Brazilian Amazonia Region.

Mem Inst Oswaldo Cruz 2018 Dec 10;114:e180450. Epub 2018 Dec 10.

Universidade Federal do Estado do Rio de Janeiro/Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.

BACKGROUND Amazon, the largest tropical forest of the world, has suffered from dengue outbreaks since 1998. Cerebrospinal fluid (CSF) of patients, from Amazonas state, suspected of central nervous system (CNS) viral infection was studied using molecular and immunological methods. OBJECTIVE To evaluate the importance of CSF investigation in patients with acute dengue virus (DENV) infection of CNS. Read More

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http://dx.doi.org/10.1590/0074-02760180450DOI Listing
December 2018
1 Read

Continued Evidence of Decline in the Enzootic Activity of Western Equine Encephalitis Virus in Colorado.

J Med Entomol 2018 Dec 6. Epub 2018 Dec 6.

Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.

Western equine encephalitis (WEE) was once prevalent and routinely isolated from mosquitoes in Colorado; however, isolations of Western equine encephalitis virus (WEEV) have not been reported from mosquito pools since the early 1990s. The objective of the present study was to test pools of Culex tarsalis (Coquillett) mosquitoes sampled from Weld County, CO, in 2016 for evidence of WEEV infection. Over 7,000 mosquitoes were tested, but none were positive for WEEV RNA. Read More

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http://dx.doi.org/10.1093/jme/tjy214DOI Listing
December 2018

Problematic molecular diagnosis of HSV-1 infection due to a single nucleotide polymorphism in the US7 gene.

J Clin Virol 2018 Dec 3;110:42-44. Epub 2018 Dec 3.

Virology Laboratory, Centre Hospitalier Universitaire de Nice, 151 Route Saint Antoine Ginestiere, 06202 Nice Cedex 3, France. Electronic address:

Background: HSV-1 infection is very common worldwide and can be associated with severe medical conditions such as encephalitis and neonatal herpes. Current diagnosis relies heavily on molecular assays targeting the viral genome. One of the pitfalls of these assays is genetic variability, as viral polymorphisms located in the target region can impair the detection of HSV-1. Read More

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http://dx.doi.org/10.1016/j.jcv.2018.12.001DOI Listing
December 2018

Platelet factor 4 promotes rapid replication and propagation of Dengue and Japanese encephalitis viruses.

EBioMedicine 2018 Dec 5. Epub 2018 Dec 5.

Disease Biology Laboratory, Regional Centre for Biotechnology, National Capital Region Biotech Science Cluster, Faridabad, India. Electronic address:

Background: Activated platelets release cytokines/proteins including CXCL4 (PF4), CCL5 and fibrinopeptides, which regulate infection of several pathogenic viruses such as HIV, H1N1 and HCV in human. Since platelet activation is the hallmark of Dengue virus (DV) infection, we investigated the role of platelets in DV replication and also in a closely related Japanese Encephalitis virus (JEV).

Methods And Findings: Microscopy and PCR analysis revealed a 4-fold increase in DV replication in primary monocytes or monocytic THP-1 cells in vitro upon incubation with either DV-activated platelets or supernatant from DV-activated platelets. Read More

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http://dx.doi.org/10.1016/j.ebiom.2018.11.049DOI Listing
December 2018

Isolation and Genome Phylogenetic Analysis of Arthropod-Borne Viruses, Including Akabane Virus, from Mosquitoes Collected in Hunan Province, China.

Vector Borne Zoonotic Dis 2018 Dec 11. Epub 2018 Dec 11.

1 State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention , Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China .

This study investigated the abundance of mosquitoes and circulation of mosquito-borne arboviruses from 16 villages in 8 cities of Hunan Province, China, in July-August of 2010 and in August of 2011. In total, 16,076 mosquitoes consisting of seven species from four genera were collected by ultraviolet-light trap. Culex quinquefasciatus was the most common species, accounting for 50. Read More

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https://www.liebertpub.com/doi/10.1089/vbz.2018.2267
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http://dx.doi.org/10.1089/vbz.2018.2267DOI Listing
December 2018
2 Reads

Autopsy in dengue encephalitis: An analysis of three cases.

Neurol India 2018 Nov-Dec;66(6):1721-1725

Department of Pathology and Neurology, Command Hospital Air Force, Bengaluru, Karnataka, India.

Dengue viral infection with unusual presentations has been described in literature, but autopsy is rarely done and is only limited to some cases, based on the literature review. Here, we present the autopsy findings in three cases of dengue encephalitis. All the three patients clinically presented with signs of meningoencephalitis and were positive for dengue non-structural (NS) 1 antigen (Ag) in the serum and cerebrospinal fluid. Read More

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http://dx.doi.org/10.4103/0028-3886.246276DOI Listing
December 2018
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A Fatal Case of Louping-ill in a Dog: Immunolocalization and Full Genome Sequencing of the Virus.

J Comp Pathol 2018 Nov 19;165:23-32. Epub 2018 Oct 19.

Moredun Research Institute, Pentlands Science Park, Bush Loan, Penicuik, Scotland, UK.

Louping-ill (LI), caused by louping-ill virus (LIV), results in a frequently fatal encephalitis primarily affecting sheep and red grouse (Lagopus lagopus scotica), but it does occur in other species. An adult male Border collie dog was definitively diagnosed with fatal LI and the lesion profile, LIV antigen distribution and full genome sequence of the LIV responsible were investigated to determine if this differed significantly from sheep-derived LIV. No gross lesions were present. Read More

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http://dx.doi.org/10.1016/j.jcpa.2018.09.004DOI Listing
November 2018
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Antigenic relationship among zoonotic flaviviruses from Italy.

Infect Genet Evol 2018 Dec 2;68:91-97. Epub 2018 Dec 2.

School of Veterinary Medicine, University of Surrey, Guildford, UK.

Here we report studies of the antigenic relationship of West Nile virus (WNV) and Usutu virus (USUV), two zoonotic flaviviruses from Italy, together with a Japanese encephalitis virus (JEV) strain and compared them with their genetic relationship using the immunodominant viral E protein. Thirty-nine isolates and reference strains were inactivated and used to immunize rabbits to produce hyper immune sera. Serum samples were tested by neutralization against all isolates and results visualized by generating antigenic map. Read More

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http://dx.doi.org/10.1016/j.meegid.2018.11.023DOI Listing
December 2018
2 Reads

Standardized focus assay protocol for biosafety level four viruses.

J Virol Methods 2018 Dec 1;264:51-54. Epub 2018 Dec 1.

Spiez Laboratory, Federal Office for Civil Protection, Austrasse, 3700, Spiez, Switzerland. Electronic address:

Working in accordance with biosafety level four practices is highly complex and time-consuming. Therefore, the respective laboratory protocols should be as uniform as possible, simple to perform and straightforward in readout. Here we describe the successful application of a standardized 24-well plate focus assay protocol for the titration of Zaire ebolavirus (two isolates), Marburg virus (three isolates), Lassa virus (two isolates), Crimean Congo hemorrhagic fever virus (one isolate), and tick-borne encephalitis virus (two isolates). Read More

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http://dx.doi.org/10.1016/j.jviromet.2018.12.002DOI Listing
December 2018
1 Read

The role of cognitive rehabilitation in limbic encephalitis: A case report.

Medicine (Baltimore) 2018 Nov;97(48):e13223

IRCCS Centro Neurolesi "Bonino-Pulejo," Messina.

Rationale: Limbic encephalitis is a parenchymal inflammation caused by viral, bacterial, or other microbial and postinfectious agents, which is usually expressed by multifocal neurological signs and cognitive impairment.

Patient Concerns: A 50-year-old female was admitted in postacute phase, at our rehabilitative Center, to undertake neuro-motor treatment for a period of 4 months.

Diagnoses: The patient was affected by limbic encephalitis. Read More

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http://dx.doi.org/10.1097/MD.0000000000013223DOI Listing
November 2018
2 Reads

Immunocompetent and Immunodeficient Mouse Models for Enterovirus 71 Pathogenesis and Therapy.

Viruses 2018 Nov 28;10(12). Epub 2018 Nov 28.

Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan.

Enterovirus 71 (EV71) is a global health threat. Children infected with EV71 could develop hand-foot-and-mouth disease (HFMD), encephalitis, paralysis, pulmonary edema, and death. At present, no effective treatment for EV71 is available. Read More

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http://dx.doi.org/10.3390/v10120674DOI Listing
November 2018
1 Read

[A 64-year-old male with recurrence of herpes simplex encephalitis after suffering from severe pneumonia and sepsis].

Rinsho Shinkeigaku 2018 Nov 29. Epub 2018 Nov 29.

Department of Neurology, NTT Medical Center Tokyo.

The case is a 64-year-old male who had a past history of herpes simplex virus encephalitis (HSE) two years prior to his admission. He was admitted to our hospital due to severe pneumonia and sepsis. Several days later, he developed HSE again. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001226DOI Listing
November 2018
1 Read

Analysis of a subacute sclerosing panencephalitis (SSPE) Genotype B3 virus from the 2009/10 South African measles epidemic shows hyperfusogenic F proteins contribute to measles virus infection in the brain.

J Virol 2018 Nov 28. Epub 2018 Nov 28.

Division of Medical Virology, Department of Clinical Laboratory Sciences, University of Cape Town and National Health Laboratory Service, Cape Town, South Africa.

During a measles virus (MeV) epidemic in 2009 in South Africa, measles inclusion body encephalitis (MIBE) was identified in several HIV-infected patients. Years later, children are presenting with subacute sclerosing panencephalitis (SSPE). To investigate the features of established MeV neuronal infections, viral sequences were analysed from brain tissue samples of a single SSPE case and compared with MIBE sequences previously obtained from patients infected during the same epidemic. Read More

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http://dx.doi.org/10.1128/JVI.01700-18DOI Listing
November 2018
1 Read

Detection of anti-viral antibodies from meat juice of wild boars.

J Vet Med Sci 2018 Nov 23. Epub 2018 Nov 23.

Laboratory of Veterinary Microbiology, Joint Faculty of Veterinary Medicine, Yamaguchi University.

Wild boars are a reservoir for many zoonotic pathogens and a good sentinel for surveillance of zoonotic viral infections, but collection of serum samples from wild boars in the field is sometimes difficult and requires special equipment and techniques. In this study, ELISA using meat juices extracted from the heart and diaphragm of wild boars, instead of serum samples, was performed to detect antibodies against zoonotic pathogens, Japanese encephalitis virus and hepatitis E virus. The results of ELISA using meat juice samples were significantly correlated with those using serum samples and meat juice contained one-fifth the antibodies of serum samples. Read More

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http://dx.doi.org/10.1292/jvms.18-0576DOI Listing
November 2018
1 Read

Diagnosis of viral central nervous system infections using antipeptide antibody against viral antigen by ELISA.

Acta Virol 2018 ;62(4):386-393

Viral infections of the central nervous system (CNS) occur sporadically and have been extensively studied because of the potential for permanent neurological damage or death. The neurotropic viruses have been reported to lead to various CNS infections. The objective of the present study is to develop an antigen detection ELISA protocol for detection and quantification of viral antigen in CNS infections by assessing the usefulness of antipeptide antibodies against potential peptides of cytomegalovirus (CMV), Epstein-Barr virus (EBV), varicella zoster virus (VZV), Japanese encephalitis virus (JEV), dengue (DENV), West Nile virus (WNV) and Chandipura virus (CHPV). Read More

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http://dx.doi.org/10.4149/av_2018_406DOI Listing
January 2018
1 Read

High neopterin and IP-10 levels in cerebrospinal fluid are associated with neurotoxic tryptophan metabolites in acute central nervous system infections.

J Neuroinflammation 2018 Nov 23;15(1):327. Epub 2018 Nov 23.

Department of Infectious Diseases, Oslo University Hospital, Ullevaal Hospital, P. O. Box 4956 Nydalen, N-0450, Oslo, Norway.

Background: The host response to intruders in the central nervous system (CNS) may be beneficial but could also be harmful and responsible for neurologic symptoms and sequelae in CNS infections. This immune response induces the activation of the kynurenine pathway (KP) with the production of neuroactive metabolites. Herein, we explored cytokine and KP responses in cerebrospinal fluid (CSF) and serum in patients with encephalitis, aseptic, and bacterial meningitis. Read More

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http://dx.doi.org/10.1186/s12974-018-1366-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260858PMC
November 2018
3 Reads

Evaluation of cholinergic functions in patients with Japanese encephalitis and Herpes simplex encephalitis.

Brain Res 2018 Nov 20. Epub 2018 Nov 20.

Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

Cognitive and memory impairment are related to cholinergic dysfunction and are important complication of viral encephalitis, In view of paucity of studies on cholinergic dysfunction in encephalitis, this study has been undertaken. We report AChE and M2 receptor levels in HSE and Japanese encephalitis (JE) patients, and correlate these with cognitive functions and MRI findings. Patients with JE and HSE were evaluated for consciousness, neurological and MRI findings , plasma AChE and M2 receptor levels on admission and after one year Results: Twenty-nine patients with JE and 23 with HSE were included . Read More

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http://dx.doi.org/10.1016/j.brainres.2018.11.028DOI Listing
November 2018
1 Read

RNA helicase A is an important host factor involved in dengue virus replication.

J Virol 2018 Nov 21. Epub 2018 Nov 21.

Department of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China

Dengue virus (DENV) utilizes host factors throughout its life cycle. In this study, we identified RNA helicase A (RHA), a member of the DEAD/H helicase family, as an important host factor of DENV. In response to DENV2 infection, nuclear RHA protein was partially redistributed into the cytoplasm. Read More

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http://dx.doi.org/10.1128/JVI.01306-18DOI Listing
November 2018
1 Read

Novel AR-12 derivatives, P12-23 and P12-34, inhibit flavivirus replication by blocking host de novo pyrimidine biosynthesis.

Emerg Microbes Infect 2018 Nov 21;7(1):187. Epub 2018 Nov 21.

Institute of Biomedical Sciences, Academia Sinica, Taipei, 11529, Taiwan.

The genus Flavivirus contains many important pathogens, including dengue virus (DENV), Zika virus (ZIKV), and Japanese encephalitis virus (JEV). AR-12 is a celecoxib-derived anticancer agent that possesses antiviral activity against a broad range of viruses. We pharmacologically exploited this unique activity to develop additional antiviral agents, resulting in the production of the AR-12 derivatives P12-23 and P12-34. Read More

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http://dx.doi.org/10.1038/s41426-018-0191-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246607PMC
November 2018
2 Reads

A neonatal mouse model of central nervous system infections caused by Coxsackievirus B5.

Emerg Microbes Infect 2018 Nov 21;7(1):185. Epub 2018 Nov 21.

Institute for Biological Products Control, National Institutes for Food and Drug Control, Beijing, China.

As one of the key members of the coxsackievirus B group, coxsackievirus B5 (CV-B5) can cause many central nervous system diseases, such as viral encephalitis, aseptic meningitis, and acute flaccid paralysis. Notably, epidemiological data indicate that outbreaks of CV-B5-associated central nervous system (CNS) diseases have been reported worldwide throughout history. In this study, which was conducted to promote CV-B5 vaccine and anti-virus drug research, a 3-day-old BALB/c mouse model was established using a CV-B5 clinical isolate (CV-B5/JS417) as the challenge strain. Read More

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http://dx.doi.org/10.1038/s41426-018-0186-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246558PMC
November 2018
4 Reads

Artificial MicroRNA-Mediated Inhibition of Japanese Encephalitis Virus Replication in Neuronal Cells.

Nucleic Acid Ther 2018 Dec 20;28(6):357-365. Epub 2018 Nov 20.

1 Vaccine and Infectious Disease Research Center (VIDRC), Translational Health Science and Technology Institute (THSTI), Faridabad, India.

Artificial microRNA (amiRNA)-mediated inhibition of viral replication has recently gained importance as a strategy for antiviral therapy. In this study, we evaluated the benefit of using the amiRNA vector against Japanese encephalitis virus (JEV). We designed three single amiRNA sequences against the consensus sequence of 3' untranslated region (3'UTR) of JEV and tested their efficacy against cell culture-grown JEV Vellore strain (P20778) in neuronal cells. Read More

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https://www.liebertpub.com/doi/10.1089/nat.2018.0743
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http://dx.doi.org/10.1089/nat.2018.0743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277082PMC
December 2018
2 Reads

A protective human monoclonal antibody targeting the West Nile virus E protein preferentially recognizes mature virions.

Nat Microbiol 2019 Jan 19;4(1):71-77. Epub 2018 Nov 19.

Viral Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

West Nile virus (WNV), a member of the Flavivirus genus, is a leading cause of viral encephalitis in the United States. The development of neutralizing antibodies against the flavivirus envelope (E) protein is critical for immunity and vaccine protection. Previously identified candidate therapeutic mouse and human neutralizing monoclonal antibodies (mAbs) target epitopes within the E domain III lateral ridge and the domain I-II hinge region, respectively. Read More

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http://www.nature.com/articles/s41564-018-0283-7
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http://dx.doi.org/10.1038/s41564-018-0283-7DOI Listing
January 2019
13 Reads

Protective antibodies against Eastern equine encephalitis virus bind to epitopes in domains A and B of the E2 glycoprotein.

Nat Microbiol 2019 Jan 19;4(1):187-197. Epub 2018 Nov 19.

Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.

Eastern equine encephalitis virus (EEEV) is a mosquito-transmitted alphavirus with a high case mortality rate in humans. EEEV is a biodefence concern because of its potential for aerosol spread and the lack of existing countermeasures. Here, we identify a panel of 18 neutralizing murine monoclonal antibodies (mAbs) against the EEEV E2 glycoprotein, several of which have 'elite' activity with 50 and 99% effective inhibitory concentrations (EC and EC) of less than 10 and 100 ng ml, respectively. Read More

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http://dx.doi.org/10.1038/s41564-018-0286-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294662PMC
January 2019
3 Reads

[Mosquitoes, midges and related arboviruses in southeast Sichuan province].

Zhonghua Liu Xing Bing Xue Za Zhi 2018 Oct;39(10):1381-1386

State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

To investigate the distribution patterns of mosquitoes, midges and related arboviruses in Sichuan province. Blood-sucking insects were collected from houses and pens, using the ultraviolet lights. Mosquito samples were classified according to morphologic characteristics and then stored at liquid nitrogen. Read More

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October 2018
1 Read

Ukrainian priorities for herpesvirus infections that affect the central nervous system.

Wiad Lek 2018 ;71(7):1289-1294

Sumy State University, Sumy, Ukraine.

Objective: Introduction: Herpesviruses (HVs) are ubiquitous pathogens that infect humans usually during childhood, followed by a life-long persistence in a latent state in many sites of a body including the nerve cells. After reactivation HVs can affect the Central Nervous System (CNS) becoming a major cause of morbidity and mortality worldwide as well as long-term neurological sequelae. Despite being an important public health problem very few population-based studies were conducted so far in the world and none in Ukraine. Read More

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January 2018
6 Reads

Detection of central nervous system viral infections in adults in Manado, North Sulawesi, Indonesia.

PLoS One 2018 16;13(11):e0207440. Epub 2018 Nov 16.

Eijkman Institute for Molecular Biology, Jakarta, Indonesia.

Central nervous system (CNS) viral infections are important causes of morbidity and mortality worldwide but the systematic survey of patients admitted to hospitals with CNS infections in many countries, including Indonesia, is limited. To obtain more information regarding the causes of CNS infections in Indonesia, this study was performed to detect and identify viral agents associated with CNS infections amongst in-patients at a referral hospital in Manado, North Sulawesi, Indonesia. Adult patients admitted to R. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207440PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239303PMC
November 2018
5 Reads

Clinical management of herpes simplex virus infections: past, present, and future.

F1000Res 2018 31;7. Epub 2018 Oct 31.

Department of Pathobiology, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, 70803, USA.

Infection with herpes simplex virus (HSV) types 1 and 2 is ubiquitous in the human population. Most commonly, virus replication is limited to the epithelia and establishes latency in enervating sensory neurons, reactivating periodically to produce localized recurrent lesions. However, these viruses can also cause severe disease such as recurrent keratitis leading potentially to blindness, as well as encephalitis, and systemic disease in neonates and immunocompromised patients. Read More

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https://f1000research.com/articles/7-1726/v1
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http://dx.doi.org/10.12688/f1000research.16157.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213787PMC
October 2018
4 Reads

Cost of managing meningitis and encephalitis among infants and children in the United States.

Diagn Microbiol Infect Dis 2018 Oct 27. Epub 2018 Oct 27.

bioMérieux, Durham, NC; Hofstra Northwell School of Medicine, Hempstead, NY.

A retrospective cohort study design was used to assess the use and costs of diagnostic tests, medication, and total hospitalization costs for pediatric patients with suspected meningitis/encephalitis who received a lumbar puncture (LP) procedure. Related costs were calculated by timing of LP performed and infectious etiology for infants (<1 year) and children (1-17 years). A total of 3030 infants and 3635 children with suspected ME diagnosed between 2011 and 2014 were included in the study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07328893183054
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http://dx.doi.org/10.1016/j.diagmicrobio.2018.10.012DOI Listing
October 2018
6 Reads

Human neural stem cell-derived neuron/astrocyte co-cultures respond to La Crosse virus infection with proinflammatory cytokines and chemokines.

J Neuroinflammation 2018 Nov 15;15(1):315. Epub 2018 Nov 15.

Department of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, 77555-0609, USA.

Background: La Crosse virus (LACV) causes pediatric encephalitis in the USA. LACV induces severe inflammation in the central nervous system, but the recruitment of inflammatory cells is poorly understood. A deeper understanding of LACV-induced neural pathology is needed in order to develop treatment options. Read More

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https://jneuroinflammation.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12974-018-1356-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236894PMC
November 2018
4 Reads

Varicella zoster virus differentially alters morphology and suppresses proinflammatory cytokines in primary human spinal cord and hippocampal astrocytes.

J Neuroinflammation 2018 Nov 15;15(1):318. Epub 2018 Nov 15.

Department of Neurology, University of Colorado School of Medicine, 4200 E. 19th Avenue, Mail Stop B182, Aurora, CO, 80045, USA.

Background: Varicella zoster virus (VZV) is a ubiquitous alphaherpesvirus that produces varicella and zoster. VZV can infect multiple cell types in the spinal cord and brain, including astrocytes, producing myelopathy and encephalopathy. While studies of VZV-astrocyte interactions are sparse, a recent report showed that quiescent primary human spinal cord astrocytes (qHA-sps) did not appear activated morphologically during VZV infection. Read More

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https://jneuroinflammation.biomedcentral.com/articles/10.118
Publisher Site
http://dx.doi.org/10.1186/s12974-018-1360-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236967PMC
November 2018
8 Reads

TIM-1 Promotes Japanese Encephalitis Virus Entry and Infection.

Viruses 2018 Nov 14;10(11). Epub 2018 Nov 14.

MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China.

Japanese encephalitis virus (JEV) is a mosquito-borne , the leading cause of viral-induced encephalitis. Several host molecules have been identified as the JEV attachment factor; however, the molecules involved in JEV entry remain poorly understood. In the present study, we demonstrate that TIM-1 is important for efficient infection by JEV. Read More

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http://dx.doi.org/10.3390/v10110630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265761PMC
November 2018
1 Read

A Sensitive Nano Luciferase Immune Complex Assay System for Highly Sensitive and Specific Detection of Antibodies Against Tick-Borne Encephalitis Virus.

Vector Borne Zoonotic Dis 2018 Nov 15. Epub 2018 Nov 15.

1 State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology , Beijing, China .

Tick-borne encephalitis virus (TBEV) can cause fever, headache, neurological disorders, and/or peripheral flaccid paralysis; therefore, it is a major threat to public health. A rapid, sensitive, and simple method for detecting anti-TBEV antibodies is needed urgently to determine infection and for vaccine evaluation. Here, a luciferase-based immunocomplex assay system (Luc-IC) was developed to detect TBEV antibodies. Read More

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https://www.liebertpub.com/doi/10.1089/vbz.2018.2330
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http://dx.doi.org/10.1089/vbz.2018.2330DOI Listing
November 2018
5 Reads
2.300 Impact Factor

Characterization of tick organic anion transporting polypeptides (OATPs) upon bacterial and viral infections.

Parasit Vectors 2018 Nov 14;11(1):593. Epub 2018 Nov 14.

Department of Biological Sciences, Old Dominion University, Norfolk, VA, USA.

Background: Ixodes scapularis organic anion transporting polypeptides (OATPs) play important roles in tick-rickettsial pathogen interactions. In this report, we characterized the role of these conserved molecules in ticks infected with either Lyme disease agent Borrelia burgdorferi or tick-borne Langat virus (LGTV), a pathogen closely related to tick-borne encephalitis virus (TBEV).

Results: Quantitative real-time polymerase chain reaction analysis revealed no significant changes in oatps gene expression upon infection with B. Read More

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http://dx.doi.org/10.1186/s13071-018-3160-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236954PMC
November 2018
2 Reads
3.430 Impact Factor

Tick-borne encephalitis in Europe, 2012 to 2016.

Euro Surveill 2018 Nov;23(45)

European Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden (affiliation when the work was performed).

Since 2012, tick-borne encephalitis (TBE) is a notifiable in the European Union. The European Centre for Disease Prevention and Control annually collects data from 28 countries plus Iceland and Norway, based on the EU case definition. Between 2012 and 2016, 23 countries reported 12,500 TBE cases (Ireland and Spain reported none), of which 11,623 (93. Read More

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https://www.eurosurveillance.org/content/10.2807/1560-7917.E
Publisher Site
http://dx.doi.org/10.2807/1560-7917.ES.2018.23.45.1800201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234529PMC
November 2018
7 Reads

Prevalence of tick-borne viruses in Ixodes ricinus assessed by high-throughput real-time PCR.

Pathog Dis 2018 Nov 1;76(8). Epub 2018 Nov 1.

UMR BIPAR, Animal Health Laboratory, ANSES, INRA, Ecole Nationale Vétérinaire d'Alfort, Université Paris-Est, 14 Rue P. et M. Curie, 94700 Maisons-Alfort, France.

Ticks are one of the principal arthropod vectors of human and animal infectious diseases. Whereas the prevalence of tick-borne encephalitis virus in ticks in Europe is well studied, there is less information available on the prevalence of the other tick-borne viruses (TBVs) existing worldwide. The aim of this study was to improve the epidemiological survey tools of TBVs by the development of an efficient high-throughput test to screen a wide range of viruses in ticks. Read More

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https://academic.oup.com/femspd/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/femspd/fty083DOI Listing
November 2018
3 Reads

[Etiology and clinical analysis of central nervous system infection caused by Coxsackievirus B5 in severe hand, foot and mouth disease in Qingdao City, 2013-2014].

Zhonghua Yu Fang Yi Xue Za Zhi 2018 Nov;52(11):1168-1172

College of Public Health, Qingdao University, Qingdao 266021, China.

To illuminate the gene characteristics and clinical characterization of Coxsackievirus B5 (CV-B5) strains isolated from patients with sevre hand, foot and mouth disease (HFMD) in Qingdao city. A total of 1 844 patients of HFMD were consecutively admitted to Qingdao Women and Children's Hospital from 2013 to 2014. Information of the study population described above was collected retrospectively. Read More

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November 2018
5 Reads

EBV-NMDA double positive encephalitis in an immunocompromised patient.

J Neurol Sci 2018 Nov 3;396:76-77. Epub 2018 Nov 3.

Department of Neurology, Ghent University Hospital, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2018.11.001DOI Listing
November 2018
1 Read

Recognition and management of febrile convulsions in children.

Br J Nurs 2018 Nov;27(20):1156-1162

Consultant Paediatrician, Torbay Hospital, Torquay.

Febrile convulsions (FCs) are characterised by convulsions associated with fever in children aged between 6 months and 6 years. FCs are relatively common and affect 3-4% of children in western countries. This is the most common seizure disorder seen in children. Read More

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http://dx.doi.org/10.12968/bjon.2018.27.20.1156DOI Listing
November 2018
1 Read

Neurologic Alterations Due to Respiratory Virus Infections.

Front Cell Neurosci 2018 26;12:386. Epub 2018 Oct 26.

Millennium Institute on Immunology and Immunotherapy (MIII), Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.

Central Nervous System (CNS) infections are one of the most critical problems in public health, as frequently patients exhibit neurologic sequelae. Usually, CNS pathologies are caused by known neurotropic viruses such as measles virus (MV), herpes virus and human immunodeficiency virus (HIV), among others. However, nowadays respiratory viruses have placed themselves as relevant agents responsible for CNS pathologies. Read More

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http://dx.doi.org/10.3389/fncel.2018.00386DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212673PMC
October 2018
1 Read

Neurosurgery in viral encephalitis: Application of decompressive craniectomy in medical diseases.

Neurochirurgie 2018 Nov 8. Epub 2018 Nov 8.

Universidad Nacional Autonoma de Nicaragua, Managua, Nicaragua.

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http://dx.doi.org/10.1016/j.neuchi.2018.10.004DOI Listing
November 2018

R430: A potent inhibitor of DNA and RNA viruses.

Sci Rep 2018 Nov 9;8(1):16662. Epub 2018 Nov 9.

Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA, 15213, USA.

Acyclovir (ACV) is an effective antiviral agent for treating lytic Herpes Simplex virus, type 1 (HSV-1) infections, and it has dramatically reduced the mortality rate of herpes simplex encephalitis. However, HSV-1 resistance to ACV and its derivatives is being increasingly documented, particularly among immunocompromised individuals. The burgeoning drug resistance compels the search for a new generation of more efficacious anti-herpetic drugs. Read More

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http://www.nature.com/articles/s41598-018-33904-y
Publisher Site
http://dx.doi.org/10.1038/s41598-018-33904-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226428PMC
November 2018
6 Reads
5.078 Impact Factor

Structure analysis and antiviral activity of CW-33 analogues against Japanese encephalitis virus.

Sci Rep 2018 Nov 9;8(1):16595. Epub 2018 Nov 9.

Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan.

Japanese encephalitis virus (JEV) is a member of neurotropic flaviviruses transmitted by mosquito bites, causing severe central nervous system disorders. Current JEV genotype III vaccines have a low protection against genotype I isolates in the risk zone. The lead compound CW-33, ethyl 2-(3',5'-dimethylanilino)-4-oxo-4,5-dihydrofuran-3-carboxylate, demonstrates the antiviral activity against JEV with an IC values of 38. Read More

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http://www.nature.com/articles/s41598-018-34932-4
Publisher Site
http://dx.doi.org/10.1038/s41598-018-34932-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226475PMC
November 2018
5 Reads

Limited Correlation of Shotgun Metagenomics Following Host Depletion and Routine Diagnostics for Viruses and Bacteria in Low Concentrated Surrogate and Clinical Samples.

Front Cell Infect Microbiol 2018 23;8:375. Epub 2018 Oct 23.

Biology Division, Spiez Laboratory, Swiss Federal Office for Civil Protection, Spiez, Switzerland.

The etiologic cause of encephalitis, meningitis or meningo-encephalitis is unknown in up to 70% of cases. Clinical shotgun metagenomics combined with host depletion is a promising technique to identify infectious etiologies of central nervous system (CNS) infections. We developed a straightforward eukaryotic host nucleic acid depletion method that preserves intact viruses and bacteria for subsequent shotgun metagenomics screening of clinical samples, focusing on cerebrospinal fluid (CSF). Read More

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https://www.frontiersin.org/article/10.3389/fcimb.2018.00375
Publisher Site
http://dx.doi.org/10.3389/fcimb.2018.00375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206298PMC
October 2018
4 Reads