21,108 results match your criteria Viral Arthritis


Macrophage Activation Syndrome (MAS) in a Recently Released Prisoner with Systemic Lupus Erythematosus (SLE).

Am J Case Rep 2018 Jun 22;19:734-738. Epub 2018 Jun 22.

Department of Rheumatology, Columbus Arthritis Center, Columbus, OH, USA.

BACKGROUND Systemic lupus erythematosus (SLE) has myriad manifestations that can affect any organ system in the body. Macrophage activation syndrome (MAS) is a disease of uncontrolled lymphocyte and macrophage proliferation and activation, which has various triggers, including autoimmune disorder, viral infection, and malignancy. We report here on MAS as a complication of adult SLE, a rare association in the literature, in a patient with an unknown past medical history. Read More

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Prevalence of Chronic Hepatitis B Infection in Patients with Systemic Lupus Erythematosus: Viral Reactivation and Impact on Disease Activity.

J Med Assoc Thai 2017 Feb;100 Suppl 1:S124-30

Background: Hepatitis B virus (HBV) infection is prevalent in many parts of the world, especially in South East Asia, and reactivation of HBV can occur after patients receive immunosuppressive agents. Systemic Lupus Erythematosus (SLE) is one of the most important autoimmune diseases because of its high morbidity and mortality rates. Most SLE patients need corticosteroid and immunosuppressive drugs as a treatment regimen; however, there are conflicting recommendations for screening for HBsAg in patients undergoing immunosuppressive therapy and diverse theories about the impact of chronic HBV infection on clinical manifestations of SLE and its activity. Read More

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February 2017

Clinical Course, Outcomes and Complications of Thai Pediatric Pure Type versus Mixed Type Lupus Membranous Nephritis.

J Med Assoc Thai 2017 Feb;100(2):158-66

Background: Due to the relative infrequency of lupus membranous nephritis (LMN) compared to other types of lupus nephritis (LN) in pediatric patients, the current literature on pediatric LMN is limited. The knowledge regarding clinical manifestations, outcomes and infectious complications are mainly based on studies in the adult population. Similar to disease expression in SLE, the renal manifestations of LMN are affected by environmental factors and vary among racial and ethnic groups. Read More

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February 2017

Signal Transducer and Activator of Transcription 3 Hyperactivation Associates With Follicular Helper T Cell Differentiation and Disease Activity in Rheumatoid Arthritis.

Front Immunol 2018 4;9:1226. Epub 2018 Jun 4.

China-Australia Centre for Personalised Immunology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Follicular helper T (Tfh) cells are the specialized CD4 T cell subset that supports B cells to produce high-affinity antibodies and generate humoral memory. Not only is the function of Tfh cells instrumental to mount protect antibodies but also to support autoantibody production and promote systemic inflammation in autoimmune diseases. However, it remains unclear how the activation of Tfh cells is driven in autoimmune diseases. Read More

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Imaging of Kingella kingae musculoskeletal infections in children: a series of 5 cases.

Emerg Radiol 2018 Jun 16. Epub 2018 Jun 16.

Department of Radiology, CSC, MC 3252, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI, 53792-3252, USA.

Purpose: Kingella kingae musculoskeletal infections continue to be under-diagnosed and there remains a paucity of literature on its imaging features. The purpose of this manuscript is to review the imaging, clinical, and laboratory findings of microbiology-proven K. kingae infections. Read More

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Clinical features of paediatric uveitis at a tertiary referral centre in São Paulo, SP, Brazil.

Br J Ophthalmol 2018 Jun 15. Epub 2018 Jun 15.

Department of Ophthalmology, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.

Aims: To analyse the clinical features, systemic associations, treatment and visual outcomes of uveitis in children from a referral centre in São Paulo, Brazil.

Methods: Clinical records of patients under 16 years old who attended the Uveitis Service, Hospital das Clinicas, Faculdadede Medicina, Universidade de São PauloFMUSP, between April and September 2017, were reviewed retrospectively. Patients with incomplete medical records, previous ocular trauma, or less than six6 months of follow-up were excluded. Read More

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Streptococcus suis cps7: an emerging virulent sequence type (ST29) shows a distinct, IgM-determined pattern of bacterial survival in blood of piglets during the early adaptive immune response after weaning.

Vet Res 2018 06 15;49(1):48. Epub 2018 Jun 15.

Institute for Bacteriology and Mycology, Centre for Infectious Diseases, Faculty of Veterinary Medicine, University Leipzig, 04103, Leipzig, Germany.

Streptococcus (S.) suis is an important porcine pathogen causing meningitis, arthritis and septicemia. As cps7 emerged recently in Germany in association with severe herd problems, the objective of this study was to characterize the geno- and phenotype of invasive cps7 strains. Read More

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Tuberculous Arthritis of the Elbow Joint: An Uncommon Location with a Diagnostic Dilemma.

Cureus 2018 Apr 11;10(4):e2462. Epub 2018 Apr 11.

Infectious Diseases, Florida Hospital-Orlando, Orlando, USA.

Musculoskeletal tuberculosis accounts for 1%-3% of all cases of tuberculosis (TB) worldwide with elbow involvement being even less common. The most cases of tuberculous arthritis occur in patients born in and emigrated from endemic regions, especially in patients who are co-infected with human immunodeficiency virus (HIV). We present a rare case of tuberculous septic arthritis of the elbow joint in a 78-year-old African-American female from the United States, with no history of travel abroad. Read More

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April 2018
2 Reads

Impact of Dietary Cholesterol on the Pathophysiology of Infectious and Autoimmune Disease.

Nutrients 2018 Jun 13;10(6). Epub 2018 Jun 13.

Department of Biology, Fairfield University, Fairfield, CT 06824, USA.

Cellular cholesterol metabolism, lipid raft formation, and lipoprotein interactions contribute to the regulation of immune-mediated inflammation and response to pathogens. Lipid pathways have been implicated in the pathogenesis of bacterial and viral infections, whereas altered lipid metabolism may contribute to immune dysfunction in autoimmune diseases, such as systemic lupus erythematosus, multiple sclerosis, and rheumatoid arthritis. Interestingly, dietary cholesterol may exert protective or detrimental effects on risk, progression, and treatment of different infectious and autoimmune diseases, although current findings suggest that these effects are variable across populations and different diseases. Read More

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Oxidative damage markers and inflammatory cytokines are altered in patients suffering with post Chikungunya persisting polyarthralgia.

Free Radic Res 2018 Jun 14:1-161. Epub 2018 Jun 14.

a Department of Laboratory Medicine , School of Tropical Medicine , Kolkata , India.

Redox homeostasis is necessary for maintenance of living systems. Chikungunya viral infection manifests into joint inflammation and debilitating polyarthralgia affecting the life style of the patient badly. The disease pathophysiology is poorly understood and there is a lack of targeted therapeutics. Read More

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Poncet's disease in an adolescent with abdominal tuberculosis.

Paediatr Int Child Health 2018 Jun 13:1-2. Epub 2018 Jun 13.

a Department of Paediatrics, Paediatric TB Clinic , B. J. Wadia Hospital for Children , Mumbai , India.

Poncet disease is a rare, acute-onset polyarthritis associated with active extra-articular tuberculosis (TB) without evidence of active infection in the affected joint and resolves without residual joint damage or long-term complications. Most cases are reported at the commencement of anti-tuberculous therapy (ATT). A 13-year-old girl with Poncet disease is reported which, despite almost 6 months of treatment for abdominal TB, manifested with bilateral knee joint involvement which resolved only with continuation of ATT. Read More

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Lyme periprosthetic joint infection in total knee arthroplasty.

Arthroplast Today 2018 Jun 19;4(2):158-161. Epub 2018 Jan 19.

Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, CT, USA.

Lyme arthritis, caused by the spirochete sensu stricto, is a common tick-borne illness in New England and the upper Midwest. Most often, the disease affects the knee and has typically been reported as a cause of native joint infection. There has been only 1 case of Lyme periprosthetic joint infection (associated with a total knee arthroplasty) reported in the literature, and to our knowledge, no other reported cases of Lyme periprosthetic joint infections exist. Read More

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Flavonoids as Th1/Th2 cytokines immunomodulators: A systematic review of studies on animal models.

Phytomedicine 2018 May 20;44:74-84. Epub 2018 Mar 20.

Division of Paediatrics, Department of Medicine, Federal University of Sergipe, Rua Cláudio Batista, s/n, Cidade Nova, Aracaju 49.100-000 Sergipe, Brazil.

Background: Flavonoids are naturally occurring compounds, extensively distributed in plants. T helper (Th)1 and Th2 cytokines balance plays an essential role in the reaction of inflammatory, allergic and infectious processes and transplantation rejection.

Purpose: This systematic review focuses on various classes of flavonoids with a view to evaluate whether Th1/Th2 cytokine-mediated pathways of immunoenhancement could reduce immune overwhelming reactions. Read More

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Serum IL-33 level is associated with auto-antibodies but not with clinical response to biologic agents in rheumatoid arthritis.

Arthritis Res Ther 2018 Jun 8;20(1):122. Epub 2018 Jun 8.

Immunology of viral Infections and Autoimmune Diseases, IDMIT, CEA - Université Paris Sud - INSERM UMR1184, Le Kremlin Bicêtre & Fontenay aux Roses, France.

Trial Registration: Rotation or Change of Biotherapy After First Anti-TNF Treatment Failure for Rheumatoid Arthritis (ROC), registered 22 October 2009, NCT01000441. Read More

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June 2018
1 Read

Pannus inflammation in sacroiliitis following immune pathological injury and radiological structural damage: a study of 193 patients with spondyloarthritis.

Arthritis Res Ther 2018 Jun 8;20(1):120. Epub 2018 Jun 8.

Department of Rheumatology, the first Affiliated Hospital of Shantou University Medical College, No.57 Chang ping Road, Shantou, 515041, Guangdong Province, China.

Background: The pathogenesis of sacroiliitis is unclear; therefore, we aimed to systematically study the immunopathology of sacroiliitis in patients with axial spondyloarthritis (axSpA), and explore the relationship between pannus formation, inflammation, and the structural damage caused by sacroiliitis.

Methods: Fine needle aspiration biopsy of the sacroiliac joint (SIJ) was performed in 193 patients with axSpA. Clinical, laboratory, and imaging data were collected at baseline and during the follow up. Read More

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Smoking-induced aggravation of experimental arthritis is dependent of aryl hydrocarbon receptor activation in Th17 cells.

Arthritis Res Ther 2018 Jun 8;20(1):119. Epub 2018 Jun 8.

Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Av. Bandeirantes, 3900, Ribeirao Preto, SP, 14049900, Brazil.

Background: Epidemiologic studies have highlighted the association of environmental factors with the development and progression of autoimmune and chronic inflammatory diseases. Among the environmental factors, smoking has been associated with increased susceptibility and poor prognosis in rheumatoid arthritis (RA). However, the immune and molecular mechanism of smoking-induced arthritis aggravation remains unclear. Read More

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[Cryoglobulins and cryoglobulinemic vasculitis].

Wiad Lek 2018 ;71(1 pt 1):59-63

Katedra i Klinika Reumatologii i Układowych Chorób Tkanki Łącznej, Uniwersytet Medyczny, Lublin, Polska.

Cryoglobulinemia is defined as the presence of cryoglobulins in the blood. Cryoglobulinemia is often observed in the course of many diseases (infection, hematological disorders, autoimmune disorders) or has an idiopathic character. The classification of cryoglobulinemia is based on the immunological analysis of cryoglobulins and the activity of the rheumatoid factor (RF). Read More

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January 2018
3 Reads

Decline of maternal antibodies to small ruminant lentivirus in goat kids.

Anim Sci J 2018 Jun 6. Epub 2018 Jun 6.

Laboratory of Veterinary Epidemiology and Economics, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland.

We carried out this study to determine for how long small ruminant lentivirus (SRLV)-specific antibodies can be detected by three commercial ELISA kits in goat kids after suckling infected does in field conditions. Forty-one kids born to SRLV-seropositive asymptomatic does were blood sampled prior to colostrum consumption, and then weekly for 6 months in total. The sera were screened with three commercial ELISA kits: whole-virus ELISA (wELISA), recombinant transmembrane and capsid antigen ELISA (TM/CA-ELISA), and surface antigen ELISA (SU-ELISA). Read More

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June 2018
2 Reads

Gene Therapy for Osteoarthritis: Pharmacokinetics of Intra-Articular Self-Complementary Adeno-Associated Virus Interleukin-1 Receptor Antagonist Delivery in an Equine Model.

Hum Gene Ther Clin Dev 2018 Jun;29(2):90-100

1 Department of Orthopedics and Rehabilitation, University of Florida , Gainesville, Florida.

Toward the treatment of osteoarthritis (OA), the authors have been investigating self-complementary adeno-associated virus (scAAV) for intra-articular delivery of therapeutic gene products. As OA frequently affects weight-bearing joints, pharmacokinetic studies of scAAV gene delivery were performed in the joints of the equine forelimb to identify parameters relevant to clinical translation in humans. Using interleukin-1 receptor antagonist (IL-1Ra) as a secreted therapeutic reporter, scAAV vector plasmids containing codon-optimized cDNA for equine IL-1Ra (eqIL-1Ra) were generated, which produced eqIL-1Ra at levels 30- to 50-fold higher than the native sequence. Read More

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June 2018
2 Reads

Self-Complementary Adeno-Associated Virus-Mediated Interleukin-1 Receptor Antagonist Gene Delivery for the Treatment of Osteoarthritis: Test of Efficacy in an Equine Model.

Hum Gene Ther Clin Dev 2018 Jun;29(2):101-112

1 Department of Orthopedics and Rehabilitation, University of Florida , Gainesville, Florida.

The authors are investigating self-complementary adeno-associated virus (scAAV) as a vector for intra-articular gene-delivery of interleukin-1 receptor antagonist (IL-1Ra), and its therapeutic capacity in the treatment of osteoarthritis (OA). To model gene transfer on a scale proportional to the human knee, a frequent site of OA incidence, studies were focused on the joints of the equine forelimb. Using AAV2. Read More

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June 2018
3 Reads

Treatment of collagenase-induced osteoarthritis with a viral vector encoding TSG-6 results in ectopic bone formation.

PeerJ 2018 30;6:e4771. Epub 2018 May 30.

Experimental Rheumatology, Radboud University Medical Center, Nijmegen, The Netherlands.

Objective: Tumor necrosis factor-inducible gene 6 (TSG-6) has anti-inflammatory and chondroprotective effects in mouse models of inflammatory arthritis. Because cartilage damage and inflammation are also observed in osteoarthritis (OA), we determined the effect of viral overexpression of TSG-6 in experimental osteoarthritis.

Methods: Bone marrow-derived cells were differentiated to multinucleated osteoclasts in the presence of recombinant TSG-6 or after transduction with a lentiviral TSG-6 expression vector. Read More

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May 2018
1 Read

Prevalence of Family History of Autoimmune Disorders in Juvenile Systemic Lupus Erythematosus.

Maedica (Buchar) 2018 Mar;13(1):21-24

Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran.

One of the causes of infants' hospitalizations is bronchiolitis, while different viral agents could be causative agents. As there is little information regarding the common agents of bronchiolitis in Iranian infants, we designed this study to determine which agents were responsible for hospitalization due to bronchiolitis among infants in an Iranian tertiary center. Two hundred and three infants with bronchiolitis who were hospitalized in Bahrami hospital were enrolled. Read More

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March 2018
2 Reads

Disseminated Exophiala dermatitidis causing septic arthritis and osteomyelitis.

BMC Infect Dis 2018 Jun 4;18(1):255. Epub 2018 Jun 4.

Division of Infectious Diseases, Department of Medicine, University of Saskatchewan, Regina, Saskatchewan, Canada.

Background: Exophiala dermatitidis is a melanized fungus isolated from many environmental sources. Infections caused by Exophiala species are typically seen in immunocompromised hosts and manifest most commonly as cutaneous or subcutaneous disease. Systemic infections are exceedingly rare and associated with significant morbidity and mortality CASE PRESENTATION: A 28-year-old female originally from India presented with fevers, chills, weight loss and increasing back pain. Read More

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June 2018
1 Read

Brucellosis in Adults and Children: A 10-Year Case Series at Two Large Academic Hospitals in Houston, Texas.

South Med J 2018 Jun;111(6):324-327

From the Departments of Medicine and Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, the Department of Medicine, Division of Infectious Diseases, University of Texas Southwestern, Dallas, and the Division of Infectious Diseases, Warren Alpert Medical School, Brown University, Providence, Rhode Island.

Objectives: Brucellosis is one of the most common zoonoses worldwide. Most cases in the United States occur among travelers or immigrants from endemic regions, mostly Central America. In this study, we aimed at describing and comparing the epidemiology and clinical presentation of brucellosis in pediatric and adult patients at two large tertiary care centers in Houston, Texas. Read More

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June 2018
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Factors Influencing Functional Outcomes of Subtalar Fusion for Posttraumatic Arthritis After Calcaneal Fracture.

Foot Ankle Int 2018 Jun 1:1071100718777492. Epub 2018 Jun 1.

1 Department of Orthopaedic Surgery, Harvard Medical School Orthopedic Trauma Initiative, Massachusetts General Hospital, Boston, MA, USA.

Background: Subtalar arthrodesis is a common salvage operation for posttraumatic subtalar arthritis. This study aimed to identify factors associated with functional outcomes and quality of life after subtalar fusion for posttraumatic subtalar arthritis after calcaneal fracture.

Methods: This is a retrospective study with follow-up by questionnaire in two level 1 trauma centers. Read More

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June 2018
2 Reads

[Rheumatological manifestations in primary immunodeficiency diseases].

Orv Hetil 2018 Jun;159(23):919-928

Klinikai Immunológiai, Felnőtt- és Gyermekreumatológiai Osztály, Országos Reumatológiai és Fizioterápiás Intézet Budapest, Frankel Leó út 38-40., 1023.

Primary immune deficiencies (PIDs) are characterized by quantitative and/or functional abnormalities of the immune system elements. Bone and joint abnormalities are not rare in patients with immunodeficiencies. Joint manifestations, of which arthritis is the most common, occur mainly in humoral PIDs (X-linked agammaglobulinemia, common variable immunodeficiency, and IgA deficiency) and occasionally in defects of the phagocyte system (chronic granulomatous disease, glicogen storage diseases). Read More

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June 2018
1 Read

[Features of the ontogenetic forms of rheumatoid arthritis associated with autoimmune thyroiditis.]

Adv Gerontol 2018 ;31(1):125-131

S.M.Kirov Military Medical Academy, 6, Acad. Lebedev str., St. Petersburg, 194044, Russian Federation;

Ontogenetic debut of diseases can determine clinico-pathogenetic differences in disease variants. The aim of the study was to determine the clinical and laboratory features of the variants of rheumatoid arthritis (RA) associated with autoimmune thyroiditis (AIT) in patients with various ontogenetic debut of the disease. A total of 53 patients with a combination of RA and AIT (mean age 63,92±1,6 years, 92% of patients - women, duration of rheumatoid arthritis - 10,0±1,11 years, disease activity on the DAS28 scale - 5,67±0,14 points). Read More

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January 2018
2 Reads

Community-acquired meningitis in adults caused by Escherichia coli in Denmark and The Netherlands.

J Infect 2018 Jun 1. Epub 2018 Jun 1.

Department of Neurology, Amsterdam Neuroscience, Academic Medical Centre, Amsterdam, The Netherlands.

Objectives: We aimed to examine risk factors, presenting characteristics and complications of Escherichia coli community-acquired bacterial meningitis in adults.

Methods: Observational cohort study of adults > 16 years of age with cerebrospinal fluid culture-positive E. coli meningitis in Denmark and the Netherlands. Read More

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June 2018
1 Read

Memory T cells specific to citrullinated α-enolase are enriched in the rheumatic joint.

J Autoimmun 2018 May 28. Epub 2018 May 28.

Rheumatology Unit, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. Electronic address:

ACPA-positive rheumatoid arthritis (RA) is associated with distinct HLA-DR alleles and immune responses to many citrullinated self-antigens. Herein we investigated the T cell epitope confined within α-enolase in the context of HLA-DRB1*04:01 and assessed the corresponding CD4 T cells in both the circulation and in the rheumatic joint. Comparative crystallographic analyses were performed for the native and citrullinated α-enolase peptides in complex with HLA-DRB1*04:01. Read More

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May 2018
1 Read

Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids.

Elife 2018 May 31;7. Epub 2018 May 31.

Division of Gastroenterology, Boston Children's Hospital, Boston, United States.

Transport of biologically active molecules across tight epithelial barriers is a major challenge preventing therapeutic peptides from oral drug delivery. Here, we identify a set of synthetic glycosphingolipids that harness the endogenous process of intracellular lipid-sorting to enable mucosal absorption of the incretin hormone GLP-1. Peptide cargoes covalently fused to glycosphingolipids with ceramide domains containing C6:0 or smaller fatty acids were transported with 20-100-fold greater efficiency across epithelial barriers in vitro and in vivo. Read More

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May 2018
2 Reads

Transcriptome Analysis of Porcine PBMCs Reveals the Immune Cascade Response and Gene Ontology Terms Related to Cell Death and Fibrosis in the Progression of Liver Failure.

Can J Gastroenterol Hepatol 2018 12;2018:2101906. Epub 2018 Apr 12.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.

Background: The key gene sets involved in the progression of acute liver failure (ALF), which has a high mortality rate, remain unclear. This study aims to gain a deeper understanding of the transcriptional response of peripheral blood mononuclear cells (PBMCs) following ALF.

Methods: ALF was induced by D-galactosamine (D-gal) in a porcine model. Read More

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April 2018
2 Reads

Miliary Histoplasmosis in a Patient with Rheumatoid Arthritis.

Case Rep Med 2018 16;2018:2723489. Epub 2018 Apr 16.

Division of Infectious Diseases, University of Colorado, Denver, CO, USA.

Miliary histoplasmosis is a rare presentation that may mimic miliary tuberculosis. We report a case of miliary histoplasmosis in a 52-year-old male who was being treated with hydroxychloroquine, methotrexate, and sulfasalazine for his rheumatoid arthritis and presented to the emergency department with shortness of breath and fevers. Computed tomography (CT) chest revealed miliary pulmonary nodules. Read More

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April 2018
1 Read

Preventive therapy for tuberculosis in rheumatological patients undergoing therapy with biological drugs.

Expert Rev Anti Infect Ther 2018 Jun 12:1-12. Epub 2018 Jun 12.

c Department of Rheumatology , Hospital of Prato , Prato , Italy.

Introduction: Latent tuberculosis infection (LTBI) accounts for almost a quarter of the world population, and, in 5-10% of the subjects with impaired immune-response against M. tuberculosis growth, it may progress to active tuberculosis (TB). In this review, we focus on the need to propose a screening for LTBI including preventive therapy offer in rheumatic patients undergoing therapy with biological drugs. Read More

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June 2018
2 Reads

Repurposing auranofin as an intestinal decolonizing agent for vancomycin-resistant enterococci.

Sci Rep 2018 May 29;8(1):8353. Epub 2018 May 29.

Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, IN, 47907, USA.

Multidrug-resistant enterococcal pathogens, especially vancomycin-resistant enterococci (VRE), are among the pathogens that require new antibiotic innovation. The colonization of the gut represents a major pathway by which VRE can cause infection and spread to other patients. In the current study, auranofin (FDA-approved rheumatoid arthritis drug) is evaluated for its potential use as a decolonizing agent for VRE. Read More

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May 2018
1 Read

Symptomatic Zika Virus Infection in Infants, Children, and Adolescents Living in Puerto Rico.

JAMA Pediatr 2018 May 29. Epub 2018 May 29.

Department of Pediatrics, St Luke's Episcopal Hospital-Ponce Health Sciences University Consortium, Ponce, Puerto Rico.

Importance: Little information is available regarding Zika virus (ZIKV) infection in children.

Objective: To describe patients younger than 18 years who were infected with ZIKV and were enrolled in the Sentinel Enhanced Dengue and Acute Febrile Illness Surveillance System (SEDSS).

Design, Setting, And Participants: Children infected with ZIKV with 7 or fewer days of fever or emancipated minors aged 14 to 17 years with a generalized maculopapular rash, arthritis or arthralgia, or nonpurulent conjunctivitis were eligible for enrollment on or before December 31, 2016, in Puerto Rico. Read More

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May 2018
3 Reads

Epidemiology and Outcomes of Granulomatosis with Polyangiitis (GPA) in Pediatric and Working-age Adults Populations in the United States: Analysis of a Large National Claims Database.

Arthritis Rheumatol 2018 May 27. Epub 2018 May 27.

Division of Pediatric Critical Care Medicine, Department of Pediatrics, Washington University, St. Louis, MO.

Objective: The incidence and prevalence of Granulomatosis with Polyangiitis (GPA) in the U.S. is not well characterized. Read More

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May 2018
1 Read

Septic arthritis due to oral streptococci following intra-articular injection: A case series.

Am J Infect Control 2018 May 24. Epub 2018 May 24.

Department of Medicine, University of Virginia Health System, Charlottesville, VA; Division of Infectious Diseases & International Health, Department of Medicine, University of Virginia Health System, Charlottesville, VA.

Oral streptococcal species are a rare cause of septic arthritis. We describe 4 cases of septic arthritis due to oral streptococcal species following joint injection. The routine use of face masks during joint injection may prevent this rare but serious complication. Read More

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May 2018
1 Read

Lethal disseminated tuberculosis in patients under biological treatment - two clinical cases and a short review.

J Int Med Res 2018 Jan 1:300060518771273. Epub 2018 Jan 1.

1 Faculty of Medicine, Ovidius University of Constanta, Constanta, Romania.

Tumour necrosis factor (TNF)-α inhibitors are highly used in Romania for the treatment of autoimmune disorders, such as rheumatoid arthritis (RA), psoriasis, inflammatory bowel diseases, and ankylosing spondylitis. Biological therapy using TNF-α inhibitors is very effective but is associated with an increased risk of opportunistic infections, including active tuberculosis. Here, two cases are presented of patients with RA and psoriasis under biological therapy who developed very aggressive forms of disseminated tuberculosis, with a rapid progression to death. Read More

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January 2018
2 Reads

Clinical Nononcologic Applications of PET/CT and PET/MRI in Musculoskeletal, Orthopedic, and Rheumatologic Imaging.

AJR Am J Roentgenol 2018 Jun;210(6):W245-W263

5 Department of Radiology, Division of Nuclear Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.

Objective: With improvements in PET/CT and PET/MRI over the last decade, as well as increased understanding of the pathophysiology of musculoskeletal diseases, there is an emerging potential for PET as a primary or complementary modality in the management of rheumatologic and orthopedic conditions.

Conclusion: We discuss the role of PET/CT and PET/MRI in nononcologic musculoskeletal disorders, including inflammatory and infectious conditions and postoperative complications. There is great potential for an increased role for PET to serve as a primary or complementary modality in the management of orthopedic and rheumatologic disorders. Read More

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June 2018
2 Reads

Arthroscopic debridement for septic arthritis of the shoulder joint: post-infectious arthritis is an inevitable consequence?

Arch Orthop Trauma Surg 2018 May 18. Epub 2018 May 18.

Department of Orthopaedic Surgery, Arthroscopy and Joint Research Institute, Severance Hospital, Yonsei University College of Medicine, CPO Box 8044, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, South Korea.

Purpose: The purpose of this study was to compare clinical outcomes and development of post-infectious arthritis of the shoulder joint after single (Group S) or repeated (Group R) arthroscopic debridement surgeries. We hypothesized that (1) repeated surgeries might be attributable to initial subchondral involvement resulting from septic arthritis and (2) the repeated surgery group would exhibit a higher incidence of post-infectious arthritic changes and inferior clinical outcomes due to prolonged resolution of the infection.

Methods: This study included 42 patients (single surgery, n = 29; repeated surgery, n = 13) who underwent arthroscopic debridement for septic arthritis and had a minimum of 2 years of postoperative follow-up data. Read More

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May 2018
1 Read

IgA vasculitis as a presentation of human immunodeficiency virus infection.

Reumatol Clin 2018 May 15. Epub 2018 May 15.

Consulta-Unidad de Enfermedades Autoinmunes Sistémicas, Unidad de Gestión Clínica de Medicina Interna, Hospital Universitario Central de Asturias, Oviedo, Asturias, España.

IgA vasculitis is a small-vessel vasculitis mediated by immune complexes. In clinical terms, it is characterized by palpable purpura in the lower limbs, joint involvement in the form of arthralgia or arthritis, and gastrointestinal and renal involvement (this will mark a poorer prognosis in adults). Infectious processes, mainly in the upper respiratory tract, are frequently found to be triggers. Read More

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May 2018
5 Reads

Long-term familial Mediterranean fever remission on successful hepatitis C virus treatment in a patient not responding to colchicine: a case report.

J Med Case Rep 2018 May 18;12(1):130. Epub 2018 May 18.

Department of Gastroenterology, "Armenia" Republican Medical Center, Yerevan, Armenia.

Background: Familial Mediterranean fever is an autosomal recessive disorder characterized by periodic febrile attacks of aseptic serositis and/or arthritis. The main treatment is colchicine which prevents attacks in the majority of patients except for a group of colchicine-resistant cases. Chronic hepatitis C is a viral infection causing chronic inflammation of liver tissue (hepatitis) which ultimately progresses to fibrosis and liver cirrhosis with a high chance of hepatocellular carcinoma. Read More

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May 2018
1 Read

Hepatitis B virus reactivation in patients with rheumatoid arthritis: Analysis of the National Database of Japan.

J Viral Hepat 2018 May 16. Epub 2018 May 16.

Department of Public Health, Chiba University Graduate School of Medicine, Chiba City, Japan.

This study aimed to determine the incidence and risk factors for hepatitis B virus (HBV) reactivation in patients with rheumatoid arthritis (RA) undergoing immunosuppressive therapy. The National Database of Japan, in which insurance claim data have been comprehensively accumulated, was utilized. The subjects were 76 641 RA patients who were plausibly initiated on immunosuppressive therapy from April 2013 to March 2014. Read More

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May 2018
1 Read

Surveillance for Lyme disease in Canada: 2009-2015.

Can Commun Dis Rep 2017 Oct 5;43(10):194-199. Epub 2017 Oct 5.

Centre for Food-borne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Saint-Hyacinthe, QC.

Objective: To summarize seven years of surveillance data for Lyme disease cases reported in Canada from 2009 to 2015.

Methods: We describe the incidence over time, seasonal and geographic distribution, demographic and clinical characteristics of reported Lyme disease cases. Logistic regression was used to explore differences between age groups, sex and year to better understand potential demographic risk factors for the occurrence of Lyme disease. Read More

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October 2017
1 Read

[Registry-based research in ophthalmology].

Ophthalmologe 2018 May 15. Epub 2018 May 15.

Universitäts-Augenklinik Bonn, Ernst-Abbe-Str. 2, 53127, Bonn, Deutschland.

Medical registries and registry studies are frequently used for health services research as they represent a valuable means of capturing real-life data. Registry studies are particularly suitable for rare diseases for which epidemiological population-based or randomized controlled clinical studies are difficult. The are many examples of successful medical registries that have not only contributed to both epidemiological and clinical research, but which have also improved health service delivery. Read More

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May 2018
1 Read

Juvenile idiopathic arthritis - the role of imaging from a rheumatologist's perspective.

Pediatr Radiol 2018 Jun 8;48(6):785-791. Epub 2018 May 8.

Rheumatology Division, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy.

Alongside recent advances in treatment strategies for juvenile idiopathic arthritis (JIA), paediatric rheumatologists have taken increasing interest in the use of imaging. Magnetic resonance imaging (MRI) and musculoskeletal ultrasound, by providing more detailed information on disease activity than clinical examination and conventional radiography (CR), have become helpful diagnostic and managerial tools. The growing skeleton, however, with changing appearances over time, is still challenging in the establishment of valid scoring systems for pathological changes. Read More

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June 2018
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Imaging of the knee in juvenile idiopathic arthritis.

Pediatr Radiol 2018 Jun 8;48(6):818-827. Epub 2018 May 8.

Department of Radiology and Nuclear Medicine, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands.

In juvenile idiopathic arthritis (JIA), imaging is increasingly used in clinical practice. In this paper we discuss imaging of the knee, the clinically most commonly affected joint in JIA. In the last decade, a number of important steps have been made in the development of imaging outcome measures in children with JIA knee involvement. Read More

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June 2018
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Current status of wrist imaging in juvenile idiopathic arthritis.

Pediatr Radiol 2018 Jun 8;48(6):801-810. Epub 2018 May 8.

Department of Radiology and Intervention Unit for Paediatric Radiology, Oslo University, Oslo, Norway.

Wrist involvement occurs in about one-quarter of patients diagnosed with juvenile idiopathic arthritis (JIA), increasing to 40% 5 years after diagnosis. The imaging appearances, both for active inflammation and permanent change, differ from those seen in adult rheumatoid arthritis; therefore, a child-specific approach is crucial for correct assessment. In this review article, we provide an update on the current status for imaging wrist JIA, with a focus on evidence-based practice. Read More

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June 2018
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Increased Mortality and Reoperation Rates After Treatment for Septic Arthritis of the Knee in People Who Inject Drugs: Nationwide Inpatient Sample, 2000-2013.

Clin Orthop Relat Res 2018 May 14. Epub 2018 May 14.

D. H. Oh, D. J. Tybor, Tufts University School of Medicine, Boston, MA, USA A. G. Wurcel, D. Burke, Department of Geographic Medicine and Infectious Diseases, Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, USA M. E. Menendez, M. J. Salzler, Department of Orthopaedics, Tufts Medical Center, Boston, MA, USA.

Background: The United States has a growing opioid epidemic impacting all aspects of health care including orthopaedic surgery. Septic arthritis of the knee is a condition commonly encountered by orthopaedic surgeons related to opioid and injection drug use (IDU). Changes in the frequency of hospitalizations for IDU-related septic arthritis and differences in septic arthritis patient outcomes according to IDU status in the setting of the burgeoning opioid epidemic are unknown. Read More

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May 2018
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