21,734 results match your criteria Viral Arthritis


Germinal center B cell initiation, GC maturation, and the coevolution of its stromal cell niches.

Immunol Rev 2019 Mar;288(1):10-27

Department of Microbiology and Immunology, Western University, London, ON, Canada.

Throughout the developing GC response, B cell survival and fate choices made at the single cell level are dependent on signals received largely through interactions with other cells, often with cognate T cells. The type of signals that a given B cell can encounter is dictated by its location within tissue microarchitecture. The focus of this review is on the initiation and evolution of the GC response at the earliest time points. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/imr.12731
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http://dx.doi.org/10.1111/imr.12731DOI Listing
March 2019
1 Read
10.120 Impact Factor

Heat Shock Proteins Can Be Surrogate Autoantigens for Induction of Antigen Specific Therapeutic Tolerance in Rheumatoid Arthritis.

Front Immunol 2019 22;10:279. Epub 2019 Feb 22.

Infectious Diseases and Immunology, Utrecht University, Utrecht, Netherlands.

Technologies that enable induction of therapeutic tolerance may revolutionize the treatment of autoimmune diseases by their supposed potential to induce drug-free and lasting disease remission. In combination with diagnostic tests that screen for individuals at risk, these approaches may offer chances to halt disease before serious damage in the tissues can occur. In fact, for healthy individuals at risk, this could lead to a preventive form of vaccination. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401592PMC
February 2019

Role of NFAT5 in the Immune System and Pathogenesis of Autoimmune Diseases.

Front Immunol 2019 19;10:270. Epub 2019 Feb 19.

Center for Integrative Rheumatoid Transcriptomics and Dynamics, The Catholic University of Korea, Seoul, South Korea.

The nuclear factor of activated T cells (NFAT5), also known as a tonicity-responsive enhancer-binding protein, was originally identified as a key transcription factor involved in maintaining cellular homeostasis against hypertonic and hyperosmotic environments. Although NFAT5 has been expressed and studied in various types of hyperosmolar tissues, evidence has emerged that NFAT5 plays a role in the development and activation of immune cells, especially T cells and macrophages. The immune-regulatory function of NFAT5 is achieved by inducing different target genes and different signaling pathways in both tonicity-dependent and -independent manners. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00270
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http://dx.doi.org/10.3389/fimmu.2019.00270DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401628PMC
February 2019
1 Read

Back pain following instillations of BCG for superficial bladder cancer is not a reactive complication: review of 30 Mycobacterium bovis BCG vertebral osteomyelitis cases.

Clin Rheumatol 2019 Mar 13. Epub 2019 Mar 13.

Department of Rheumatology, Centre Hospitalier Universitaire de Rennes, 35000, Rennes, France.

Mycobacterium bovis Bacillus Calmette-Guérin (BCG) instillations are used in bladder cancer treatment. Adverse effects can occur. Osteoarticular complications are mainly reactive arthritis, but true infections have been described, such as vertebral osteomyelitis. Read More

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http://dx.doi.org/10.1007/s10067-019-04500-wDOI Listing

Chikungunya virus in Asia - Pacific: a systematic review.

Emerg Microbes Infect 2019 ;8(1):70-79

a Institute of Health and Biomedical Innovation, School of Biomedical Sciences , Queensland University of Technology , Brisbane , QLD , Australia.

Chikungunya virus (CHIKV) is a mosquito-borne pathogen that causes an acute febrile syndrome and severe, debilitating rheumatic disorders in humans that may persist for months. CHIKV's presence in Asia dates from at least 1954, but its epidemiological profile in the region remains poorly understood. We systematically reviewed CHIKV emergence, epidemiology, clinical features, atypical manifestations and distribution of virus genotypes, in 47 countries from South East Asia (SEA) and the Western Pacific Region (WPR) during the period 1954-2017. Read More

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https://www.tandfonline.com/doi/full/10.1080/22221751.2018.1
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http://dx.doi.org/10.1080/22221751.2018.1559708DOI Listing
January 2019
1 Read

Edema Toxin Inhibits Efferocytosis in Human Macrophages and Alters Efferocytic Receptor Signaling.

Int J Mol Sci 2019 Mar 7;20(5). Epub 2019 Mar 7.

Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA.

The Edema Toxin (ET), composed of a Protective Antigen (PA) and the Edema Factor (EF), is a cellular adenylate cyclase that alters host responses by elevating cyclic adenosine monophosphate (cAMP) to supraphysiologic levels. However, the role of ET in systemic anthrax is unclear. Efferocytosis is a cAMP-sensitive, anti-inflammatory process of apoptotic cell engulfment, the inhibition of which may promote sepsis in systemic anthrax. Read More

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http://dx.doi.org/10.3390/ijms20051167DOI Listing

Mechanisms of human Foxp3 T cell development and function in health and disease.

Clin Exp Immunol 2019 Mar 12. Epub 2019 Mar 12.

Department of Microbiology and Immunology, McGill University, Montréal, Québec, Canada, H3A 2B4.

Regulatory T (T ) cells represent an essential component of peripheral tolerance. Given their potently immunosuppressive functions orchestrated by the lineage-defining transcription factor Foxp3, clinical modulation of these cells in autoimmunity and cancer is a promising therapeutic target. However, recent evidence in mice and humans indicates that T cells represent a phenotypically and functionally heterogeneic immune cell population. Read More

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http://dx.doi.org/10.1111/cei.13290DOI Listing

Inflammation and Lymphatic Function.

Front Immunol 2019 26;10:308. Epub 2019 Feb 26.

Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland.

The lymphatic vasculature plays a crucial role in regulating the inflammatory response by influencing drainage of extravasated fluid, inflammatory mediators, and leukocytes. Lymphatic vessels undergo pronounced enlargement in inflamed tissue and display increased leakiness, indicating reduced functionality. Interfering with lymphatic expansion by blocking the vascular endothelial growth factor C (VEGF-C)/vascular endothelial growth factor receptor 3 (VEGFR-3) signaling axis exacerbates inflammation in a variety of disease models, including inflammatory bowel disease (IBD), rheumatoid arthritis and skin inflammation. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399417PMC
February 2019
1 Read

Galectin-9 and CXCL10 as biomarkers for disease activity in juvenile dermatomyositis: a longitudinal cohort study and multi-cohort validation.

Arthritis Rheumatol 2019 Mar 12. Epub 2019 Mar 12.

Laboratory of translational immunology, University Medical Centre Utrecht, Utrecht, The Netherlands.

Objective: Objective evaluation of disease activity is challenging in patients with juvenile dermatomyositis (JDM) due to lack of biomarkers, but crucial to avoid both under- and overtreatment. Recently, we identified two proteins that highly correlate with JDM disease activity: galectin-9 and CXCL10. Here, we validate galectin-9 and CXCL10 as biomarkers for disease activity, assess disease-specificity and investigate their potency to predict flares. Read More

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http://dx.doi.org/10.1002/art.40881DOI Listing

Safety and efficacy of prolonged use of dalbavancin in bone and joint infections.

Antimicrob Agents Chemother 2019 Mar 11. Epub 2019 Mar 11.

Department of Infectious diseases, Hospital Clínic of Barcelona, IDIBAPS, University of Barcelona.

: Dalbavancin is a lipoglycopeptide with potent activity against gram-positive microorganisms, with a long half-life, favorable safety profile and a high bone concentration which makes it an interesting alternative for osteoarticular infections.: Multicentric retrospective study of all patients with an osteoarticular infection (septic arthritis, spondylodiscitis, osteomyelitis or orthopedic implant related infections) treated with at least one dose of dalbavancin between 2016 and 2017 in 30 institutions in Spain. In order to evaluate the response, patients with or without an orthopedic implant were separated. Read More

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http://aac.asm.org/lookup/doi/10.1128/AAC.02280-18
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http://dx.doi.org/10.1128/AAC.02280-18DOI Listing
March 2019
2 Reads

Cutaneous infection by Phaeoacremonium parasiticum.

Rev Iberoam Micol 2019 Mar 7. Epub 2019 Mar 7.

Department of Microbiology, Hospital Clínic, Universitat de Barcelona, ISGLOBAL, Barcelona, Spain.

Background: Phaeoacremonium parasiticum is considered a rare infectious agent that is part of a heterogeneous group of fungi causing phaeohyphomycosis. This organism is capable of producing subcutaneous infections, eumycetomas, osteomyelitis, arthritis, myositis and also disseminated diseases, such as fungemia and endocarditis.

Case Report: We describe a case of cutaneous infection by P. Read More

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http://dx.doi.org/10.1016/j.riam.2018.10.003DOI Listing

Impact of the subclinical small ruminant lentivirus infection of female goats on the litter size and the birth body weight of kids.

Prev Vet Med 2019 Apr 22;165:71-75. Epub 2019 Feb 22.

Laboratory of Veterinary Epidemiology and Economics, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 159c, 02-776, Warsaw, Poland.

A longitudinal study was conducted in a single dairy goat herd to investigate the relationship between subclinical small ruminant lentivirus (SRLV) infection in does and litter size (LS) or birth body weight of kids (BW). Each year kids born to seropositive and seronegative does were weighed before the first consumption of colostrum. LS and BW of each kid were recorded. Read More

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http://dx.doi.org/10.1016/j.prevetmed.2019.02.011DOI Listing
April 2019
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Association of Autoimmune Connective Tissue Disease and Outcomes in Patients Undergoing Transcatheter Aortic Valve Implantation.

Am J Cardiol 2019 Feb 22. Epub 2019 Feb 22.

Cardiovascular Outcomes Research Laboratories, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California; Division of Cardiac Surgery, University of California, Los Angeles, Los Angeles, California. Electronic address:

Patients with autoimmune connective tissue disease (CTD) are at higher risk for developing aortic valve pathology, but the safety and value of transcatheter aortic valve implantation (TAVI) in this population has not been investigated. This study evaluated mortality, complication, and readmission rates along with length of stay and total costs after TAVI in patients with CTD. We retrospectively reviewed 47,216 patients who underwent TAVI from the National Readmissions Database between January 2011 and September 2015. Read More

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http://dx.doi.org/10.1016/j.amjcard.2019.02.023DOI Listing
February 2019

Gene expression profiling meta-analysis reveals novel gene signatures and pathways shared between tuberculosis and rheumatoid arthritis.

Authors:
M T Badr G Häcker

PLoS One 2019 7;14(3):e0213470. Epub 2019 Mar 7.

Institute of Medical Microbiology and Hygiene, Medical Center-University of Freiburg, Faculty of Medicine, Freiburg, Germany.

Tuberculosis (TB) is among the leading causes of death by infectious diseases. An epidemiological association between Mycobacterium tuberculosis infection and autoimmune diseases like rheumatoid arthritis (RA) has been reported but it remains unclear if there is a causal relationship, and if so, which molecular pathways and regulatory mechanisms contribute to it. Here we used a computational biology approach by global gene expression meta-analysis to identify candidate genes and pathways that may link TB and RA. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213470PLOS
March 2019
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Antibody neutralization of microbiota-derived circulating peptidoglycan dampens inflammation and ameliorates autoimmunity.

Nat Microbiol 2019 Mar 4. Epub 2019 Mar 4.

Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore.

The human microbiota provides tonic signals that calibrate the host immune response, but their identity is unknown. Bacterial peptidoglycan (PGN) subunits are likely candidates since they are well-known immunity-enhancing adjuvants, released by most bacteria during growth, and have been found in the blood of healthy people. We developed a monoclonal antibody (mAb), 2E7, that targets muramyl-L-alanyl-D-isoglutamine (MDP), a conserved and minimal immunostimulatory structure of PGN. Read More

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http://dx.doi.org/10.1038/s41564-019-0381-1DOI Listing
March 2019
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Genetic variation of matrix metalloproteinase enzyme in HIV-associated neurocognitive disorder.

Gene 2019 Feb 27;698:41-49. Epub 2019 Feb 27.

Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India.

Matrix metalloproteinases (MMPs) play a key role in several diseases such as rheumatoid arthritis, HIV-associated neurological diseases (HAND), multiple sclerosis, osteoporosis, stroke, Alzheimer's disease, certain viral infections of the central nervous system, cancer, and hepatitis C virus. MMPs have been explained with regards to extracellular matrix remodeling, which occurs throughout life and ranges from tissue morphogenesis to wound healing in various processes. MMP are inhibited by endogenous tissue inhibitors of metalloproteinases (TIMPs). Read More

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http://dx.doi.org/10.1016/j.gene.2019.02.057DOI Listing
February 2019
3 Reads

TBA, a fusion toxoid vaccine for protection and broad neutralization of staphylococcal superantigens.

Sci Rep 2019 Mar 1;9(1):3279. Epub 2019 Mar 1.

Integrated Biotherapeutics, Inc., Rockville, MD, USA.

Superantigens (SAgs) play a major role in the pathogenesis of Staphylococcus aureus and are associated with several diseases, including food poisoning, bacterial arthritis, and toxic shock syndrome. Monoclonal antibodies to these SAgs, primarily TSST-1, SEB and SEA have been shown to provide protection in animal studies and to reduce clinical severity in bacteremic patients. Here we quantify the pre-existing antibodies against SAgs in many human plasma and IVIG samples and demonstrate that in a major portion of the population these antibody titers are suboptimal and IVIG therapy only incrementally elevates the anti-SAg titers. Read More

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http://dx.doi.org/10.1038/s41598-019-39890-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397225PMC
March 2019
1 Read

Leflunomide-induced colitis in association with enterocutaneous fistula in an immunosuppressed patient with renal transplant and rheumatoid arthritis.

Clin J Gastroenterol 2019 Feb 28. Epub 2019 Feb 28.

Department of Surgery, Wollongong Hospital, South Cost Mail Centre, Locked Bag 8808, Wollongong, NSW, 2521, Australia.

We describe the case of a 68-year-old man who has a complex medical background that included renal transplantation, rheumatoid arthritis and atrial fibrillation. Because of this, he was taking a number of immunosuppressant medications including leflunomide, prednisone and tacrolimus. He had experienced chronic diarrhoea over 18 months which had acutely worsened over the 6 weeks prior to hospital presentation. Read More

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http://dx.doi.org/10.1007/s12328-019-00954-2DOI Listing
February 2019

An effective management strategy for the control of two lentiviruses in goat breedings.

J Theor Biol 2019 Feb 26;469:96-106. Epub 2019 Feb 26.

Department of Veterinary Sciences, University of Torino, Italy. Electronic address:

Caprine Arthritis Encephalitis is an endemic disease in goat breedings, caused by viral strains belonging to the Small Ruminant Lentivirus group and characterized by a progressive chronic course. Its clinical signs are not immediately recognizable and can only be detected via costly serological tests. No vaccine is available. Read More

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http://dx.doi.org/10.1016/j.jtbi.2019.02.018DOI Listing
February 2019
2 Reads

Performance of automated multiplex polymerase chain reaction (mPCR) using synovial fluid in the diagnosis of native joint septic arthritis in adults.

Bone Joint J 2019 Mar;101-B(3):288-296

Medical University of Vienna, Department of Orthopaedics and Trauma Surgery, Vienna, Austria.

Aims: This study aimed to assess the performance of an automated multiplex polymerase chain reaction (mPCR) technique for rapid diagnosis of native joint septic arthritis.

Patients And Methods: Consecutive patients with suspected septic arthritis undergoing aseptic diagnostic joint aspiration were included. The aspirate was used for analysis by mPCR and conventional microbiological analysis. Read More

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https://online.boneandjoint.org.uk/doi/10.1302/0301-620X.101
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http://dx.doi.org/10.1302/0301-620X.101B3.BJJ-2018-0868.R1DOI Listing
March 2019
4 Reads

The Platelet-to-Lymphocyte Ratio as an Inflammatory Marker in Rheumatic Diseases.

Ann Lab Med 2019 Jul;39(4):345-357

Departments of Rheumatology and Research and Development, Dudley Group NHS Foundation Trust (Teaching Trust of the University of Birmingham, UK), Russells Hall Hospital, Dudley, West Midlands, UK.

The platelet-to-lymphocyte ratio (PLR) has emerged as an informative marker revealing shifts in platelet and lymphocyte counts due to acute inflammatory and prothrombotic states. PLR has been extensively examined in neoplastic diseases accompanied by immune suppression and thrombosis, which can be predicted by combined blood cell counts and their ratios. Several large observational studies have demonstrated the value of shifts in PLR in evaluating the severity of systemic inflammation and predicting infections and other comorbidities, in inflammatory rheumatic diseases. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.3343/alm.2019.39
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http://dx.doi.org/10.3343/alm.2019.39.4.345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400713PMC
July 2019
5 Reads

Janus kinases to jakinibs: from basic insights to clinical practice.

Rheumatology (Oxford) 2019 Feb;58(Supplement_1):i4-i16

Molecular Immunology and Inflammation Branch, National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, USA.

Cytokines are critical mediators of diverse immune and inflammatory diseases. Targeting cytokines and cytokine receptors with biologics has revolutionized the treatment of many of these diseases, but targeting intracellular signalling with Janus kinase (JAK) inhibitors (jakinibs) now represents a major new therapeutic advance. We are still in the first decade since these drugs were approved and there is still much to be learned about the mechanisms of action of these drugs and the practical use of these agents. Read More

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http://dx.doi.org/10.1093/rheumatology/key432DOI Listing
February 2019
7 Reads

Latent tuberculosis infection and non-infectious co-morbidities: Diabetes mellitus type 2, chronic kidney disease and rheumatoid arthritis.

Int J Infect Dis 2019 Mar 22;80S:S29-S31. Epub 2019 Feb 22.

Infection & Immunity Research Institute, St. George's, University of London, United Kingdom.

The prevalence of non-communicable diseases is increasing worldwide, which coincides with the persistence of infectious diseases including tuberculosis. These can synergistically affect individual and population health. Three non-communicable diseases that are relevant because of their associated morbidity, mortality and disability are type 2 diabetes mellitus, chronic kidney disease and rheumatoid arthritis. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.018DOI Listing

Regulation of TLR signaling pathways by microRNAs: implications in inflammatory diseases.

Cent Eur J Immunol 2018 31;43(4):482-489. Epub 2018 Dec 31.

Centro de Investigacion en Alimentacion y Desarrollo, AC, Hermosillo, Mexico.

The control of the immune response during the development of some diseases is crucial for the maintenance or restoration of homeostasis. Several mechanisms can initiate inflammation, one of which is the activation of toll-like receptors (TLRs), necessary to initiate the immune response to eliminate an infection. However, inappropriate activation can compromise immunological homeostasis, leading to pathologies such as autoimmune diseases, chronic inflammation, and even cancer. Read More

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http://dx.doi.org/10.5114/ceji.2018.81351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384427PMC
December 2018
1 Read

A Case of Calcium Pyrophosphate Deposition Disease Involving a Lumbar Facet Joint Following Urinary Tract Infection.

Intern Med 2019 Feb 25. Epub 2019 Feb 25.

Disease Control and Prevention Center, National Center for Global Health and Medicine, Japan.

A 75-year-old woman was admitted with urosepsis due to Escherichia coli infection. After improvement with a ureteral stent and antimicrobial agent, she complained of back pain and showed elevated inflammation marker levels. Arthralgia and arthritis of multiple peripheral joints were noted, and radiography indicated cartilage calcification. Read More

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http://dx.doi.org/10.2169/internalmedicine.2099-18DOI Listing
February 2019
1 Read

Clostridioides difficile-related toxic megacolon after Cryptococcus neoformans cellulitis: A complex of two rare infections in an immunocompromised host.

J Infect Chemother 2019 Feb 21. Epub 2019 Feb 21.

Department of Clinical Infectious Diseases, Aichi Medical University Hospital, Nagakute, Aichi, Japan; Department of Infection Control and Prevention, Aichi Medical University Hospital, Nagakute, Aichi, Japan. Electronic address:

A 76-year-old Japanese woman was admitted due to uncontrolled cellulitis of the right lower leg. She had deep vein thrombosis on the right limb. Moreover, she had a long history of rheumatoid arthritis treated with corticosteroids. Read More

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http://dx.doi.org/10.1016/j.jiac.2018.12.003DOI Listing
February 2019
2 Reads

Chronic meningococcemia.

IDCases 2019 2;15:e00502. Epub 2019 Feb 2.

Infectious Diseases Department, Centro Hospitalar Universitário de São João, Alameda Professor Hernani Monteiro, 4200-319, Porto, Portugal.

The spectrum of -associated clinical entities involves mild forms of disease, without neurological involvement or sepsis, and asymptomatic carrier states. Rarely, bacteremia can be associated with a prolonged fever with or without arthritis, which we designate as chronic meningococcemia. Chronic meningococcemia is an uncommon entity, usually associated to serogroup B . Read More

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http://dx.doi.org/10.1016/j.idcr.2019.e00502DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370544PMC
February 2019
1 Read

Top-down Mass Spectrometry Analysis of Human Serum Autoantibody Antigen-Binding Fragments.

Sci Rep 2019 Feb 20;9(1):2345. Epub 2019 Feb 20.

Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK, 73019, USA.

Detecting autoimmune diseases at an early stage is crucial for effective treatment and disease management to slow disease progression and prevent irreversible organ damage. In many autoimmune diseases, disease-specific autoantibodies are produced by B cells in response to soluble autoantigens due to defects in B cell tolerance mechanisms. Autoantibodies accrue early in disease development, and several are so disease-specific they serve as classification criteria. Read More

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http://dx.doi.org/10.1038/s41598-018-38380-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382847PMC
February 2019
1 Read

arthritis and pneumonia in calves in Jordan: An emerging disease.

Vet World 2018 Dec 12;11(12):1663-1668. Epub 2018 Dec 12.

Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan.

Aim: Clinical, microbiological, molecular, and pathological assays were undertaken to characterize an outbreak of increasingly reported signs of unresponsive arthritis and pneumonia of infection in young calves in Jordan.

Materials And Methods: Clinical history of the affected bovine herd was investigated for the presence of respiratory and/or joint problems. Two calves with such history were clinically examined and necropsied. Read More

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http://www.veterinaryworld.org/Vol.11/December-2018/3.html
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http://dx.doi.org/10.14202/vetworld.2018.1663-1668DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362338PMC
December 2018
6 Reads

Design, synthesis and biological evaluation of low molecular weight CXCR4 ligands.

Bioorg Med Chem 2019 Feb 6. Epub 2019 Feb 6.

Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan; Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8150, Japan. Electronic address:

The chemokine receptor CXCR4/stromal cell-derived factor-1 (SDF-1: CXCL12) signaling axis represents a crucial drug target due to its relevance to several diseases such as HIV-1 infection, cancer, leukemia, and rheumatoid arthritis. With the aim of enhancing the binding affinity and anti-HIV activity of a potent CXCR4 ligand as a lead, 23 low molecular weight compounds containing dipicolylamine (Dpa) and cyclam cationic moieties with varying spacers and spatial positioning were designed, synthesized and biologically evaluated. All of the synthesized compounds screened at 1. Read More

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http://dx.doi.org/10.1016/j.bmc.2019.02.013DOI Listing
February 2019
1 Read
2.793 Impact Factor

Innate Immune Modulation by GM-CSF and IL-3 in Health and Disease.

Int J Mol Sci 2019 Feb 15;20(4). Epub 2019 Feb 15.

Department of Translational Medical Sciences and Center for Basic and Clinical Immunology Research (CISI), University of Naples Federico II, 80131 Naples, Italy.

Granulocyte-macrophage colony-stimulating factor (GM-CSF) and inteleukin-3 (IL-3) have long been known as mediators of emergency myelopoiesis, but recent evidence has highlighted their critical role in modulating innate immune effector functions in mice and humans. This new wealth of knowledge has uncovered novel aspects of the pathogenesis of a range of disorders, including infectious, neoplastic, autoimmune, allergic and cardiovascular diseases. Consequently, GM-CSF and IL-3 are now being investigated as therapeutic targets for some of these disorders, and some phase I/II clinical trials are already showing promising results. Read More

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http://dx.doi.org/10.3390/ijms20040834DOI Listing
February 2019
5 Reads

IL33/ST2 Axis in Diabetic Kidney Disease: A Literature Review.

Medicina (Kaunas) 2019 Feb 14;55(2). Epub 2019 Feb 14.

School and Operative Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, 98125 Messina, Italy.

Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, playing a role in inflammatory, infectious and autoimmune diseases and expressed in the cellular nucleus in several tissues. High levels of IL-33 are expressed in epithelial barrier tissues and endothelial barriers. ST2 is a receptor for IL-33, expressed selectively on a subset of Th2 cells, mediating some of their functions. Read More

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http://dx.doi.org/10.3390/medicina55020050DOI Listing
February 2019
2 Reads

Neutrophil-derived lactoferrin induces the inflammatory responses of rheumatoid arthritis synovial fibroblasts via Toll-like receptor 4.

Clin Exp Rheumatol 2019 Feb 11. Epub 2019 Feb 11.

Department of Rheumatology, Infectious Diseases, and Laboratory Medicine, Faculty of Medicine, University of Miyazaki, Japan.

Objectives: Damage-associated molecular patterns (DAMPs) are proposed to drive aberrant stimulation of Toll-like receptors (TLRs) in rheumatoid arthritis (RA) inflamed joints. In the current study we investigated the role of the neutrophil-derived lactoferrin (LTF), as an endogenous ligand for TLR4 in the inflammatory response of RA synovial fibroblasts (RASFs).

Methods: RASFs were stimulated with LTF, and the expressions of inflammatory cytokines in RASFs were measured. Read More

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February 2019
2 Reads

Predictive value of ex-vivo drug-inhibited cytokine production for clinical response to biologic DMARD therapy in rheumatoid arthritis.

Clin Exp Rheumatol 2019 Feb 7. Epub 2019 Feb 7.

Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.

Objectives: To investigate ex-vivo drug-inhibited cytokine production before the start of a biological DMARD (bDMARD) as predictor of treatment response in rheumatoid arthritis (RA).

Methods: In a prospective RA cohort study [BIO-TOP], blood samples were obtained from patients before the start of a bDMARD (abatacept, adalimumab, etanercept, rituximab or tocilizumab). Peripheral blood mononuclear cells were pre-incubated for 1 hour with the therapeutic in-vivo concentration of the bDMARD and stimulated for 24 hours with heat-killed Candida albicans or Pam3Cys. Read More

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February 2019
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Calm in the midst of cytokine storm: a collaborative approach to the diagnosis and treatment of hemophagocytic lymphohistiocytosis and macrophage activation syndrome.

Pediatr Rheumatol Online J 2019 Feb 14;17(1). Epub 2019 Feb 14.

Division of Immunolgy, Boston Children's Hospital, Boston, MA, USA.

Background: Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) were historically thought to be distinct entities, often managed in isolation. In fact, these conditions are closely related. A collaborative approach, which incorporates expertise from subspecialties that previously treated HLH/MAS independently, is needed. Read More

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https://ped-rheum.biomedcentral.com/articles/10.1186/s12969-
Publisher Site
http://dx.doi.org/10.1186/s12969-019-0309-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376762PMC
February 2019
7 Reads

Relative risk of tuberculosis in patients with rheumatic diseases managed with anti-tumour necrosis factor-alpha therapy: A nationwide cohort study.

J Clin Pharm Ther 2019 Feb 14. Epub 2019 Feb 14.

Turkish Medicines and Medical Devices Agency, Ministry of Health, Ankara, Turkey.

What Is Known And Objective: Anti-tumour necrosis factor-alpha (anti-TNF-α) therapy is known to raise the risk of granulomatous infections, leading to development of risk management strategies at national or global level. This study aimed to determine the relative risk (RR) of tuberculosis (TB) due to anti-TNF-α usage in patients with rheumatologic diseases (RDs) in a nationwide basis.

Method: This retrospective cohort study included patients with rheumatoid arthritis (RA), ankylosing spondylitis, juvenile idiopathic arthritis or psoriatic arthritis (PsA) that treated with or without anti-TNF-α agents, as registered in the national prescription information system between years 2013 and 2015. Read More

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http://dx.doi.org/10.1111/jcpt.12814DOI Listing
February 2019
1 Read

Seronegative Bilateral Symmetrical Inflammatory Polyarthritis: Think Twice Before Starting Immunosuppression.

Eur J Case Rep Intern Med 2018 28;5(8):000895. Epub 2018 Aug 28.

Department of Medicine (Rheumatology), Hamad Medical Corporation, Doha, Qatar.

The most common cause of bilateral symmetrical polyarthritis in the small joints is rheumatoid arthritis. However, if seronegative arthritis is involved, it could be the case that other underlying causes need to be diagnosed. This is particularly important for those coming from or living in developing countries where infectious causes should always be considered. Read More

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http://dx.doi.org/10.12890/2018_000895DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346836PMC
August 2018
1 Read

Tuberculous Arthritis of the Ankle.

Eur J Case Rep Intern Med 2018 26;5(6):000870. Epub 2018 Jun 26.

Department of Internal and Emergency Medicine, Catholic University of the Sacred Heart School of Medicine, Rome, Italy.

Tuberculosis (TB) is an infectious disease caused by the s complex (MTBC). Pulmonary TB is the most common form of presentation, but extrapulmonary tuberculosis (EPTB) contributes significantly to morbidity and mortality. Rarely, patients with EPTB develop a form of ankle or foot arthritis. Read More

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http://dx.doi.org/10.12890/2018_000870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346884PMC
June 2018
3 Reads

Native joint septic arthritis due to Clostridium tarantellae.

Anaerobe 2019 Feb 10;56:46-48. Epub 2019 Feb 10.

Laboratory of Microbiology, Department of Infectious Agents, Saint Louis - Lariboisiere - Fernand Widal University Hospital, APHP, Paris, France; IAME, UMR 1137, INSERM, Paris Diderot University, Sorbonne Paris Cité, Paris, France.

Clostridium is a diverse genus including more than 200 species involved in varied clinical presentations in infectious diseases. Septic arthritis caused by Clostridium sp. are however uncommon. Read More

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http://dx.doi.org/10.1016/j.anaerobe.2019.02.004DOI Listing
February 2019
1 Read

Immunotherapy for skin cancer.

Int Immunol 2019 Feb 8. Epub 2019 Feb 8.

Cutaneous Development and Carcinogenesis Section, National Institute of Arthritis and Musculoskeletal Skin Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.

Among all tumor types, skin cancers are profoundly sensitive to immunotherapy. Indeed, the recently reported response rates for anti-PD-1 (anti-programmed-death 1) therapy for cutaneous malignant melanomas (MM), Merkel cell carcinomas, basal cell carcinomas, cutaneous squamous cell carcinomas and Kaposi sarcomas are all above 40%. This unique immunogenicity renders skin cancers as a paradigm for tumor-immune interactions and is driven by high mutational burdens, overexpressed tumor antigens and/or viral antigens. Read More

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https://academic.oup.com/intimm/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/intimm/dxz012DOI Listing
February 2019
4 Reads

IFN-γ-dependent nitric oxide suppresses Brucella-induced arthritis by inhibition of inflammasome activation.

J Leukoc Biol 2019 Feb 12. Epub 2019 Feb 12.

Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, USA.

Brucellosis, caused by the intracellular bacterial pathogen Brucella, is a globally important zoonotic disease for which arthritis is the most common focal complication in humans. Wild-type mice infected systemically with Brucella typically do not exhibit arthritis, but mice lacking IFN-γ develop arthritis regardless of the route of Brucella infection. Here, we investigated mechanisms by which IFN-γ suppresses Brucella-induced arthritis. Read More

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http://dx.doi.org/10.1002/JLB.4MIA1018-409RDOI Listing
February 2019
2 Reads

Inhibition of IL-1β signaling by anakinra shows a critical role for bone loss in experimental arthritogenic alphavirus infections.

Arthritis Rheumatol 2019 Feb 12. Epub 2019 Feb 12.

Institute for Glycomics, Griffith University, Gold Coast Campus, QLD, Australia.

Objective: Arthritogenic alphaviruses, such as Ross River virus (RRV), chikungunya virus (CHIKV), Sindbis virus (SINV), Barmah Forest virus, o'nyong-nyong virus and Mayaro virus cause sporadic and sometimes large outbreaks worldwide. These viruses particularly affect joints of the extremities and can lead to debilitating and potentially chronic polyarthritis/polyarthralgia. The host's innate immune response plays a crucial role in inducing pro-inflammatory host factors, leading to tissue destruction and bone loss in the joints. Read More

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http://doi.wiley.com/10.1002/art.40856
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http://dx.doi.org/10.1002/art.40856DOI Listing
February 2019
4 Reads

Extensive transmission of microbes along the gastrointestinal tract.

Elife 2019 Feb 12;8. Epub 2019 Feb 12.

Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.

The gastrointestinal tract is abundantly colonized by microbes, yet the translocation of oral species to the intestine is considered a rare aberrant event, and a hallmark of disease. By studying salivary and fecal microbial strain populations of 310 species in 470 individuals from five countries, we found that transmission to, and subsequent colonization of, the large intestine by oral microbes is common and extensive among healthy individuals. We found evidence for a vast majority of oral species to be transferable, with increased levels of transmission in colorectal cancer and rheumatoid arthritis patients and, more generally, for species described as opportunistic pathogens. Read More

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http://dx.doi.org/10.7554/eLife.42693DOI Listing
February 2019
2 Reads

Combined Blockade of TNF-α and IL-17A Alleviates Progression of Collagen-Induced Arthritis without Causing Serious Infections in Mice.

J Immunol 2019 Feb 11. Epub 2019 Feb 11.

Immunology Discovery, Janssen Research and Development, LLC, Spring House, PA 19477;

The cytokines TNF-α and IL-17A are elevated in a variety of autoimmune diseases, including rheumatoid arthritis. Both cytokines are targets of several biologic drugs used in the clinic, but unfortunately many patients are refractory to these therapies. IL-17A and TNF-α are known to mediate signaling synergistically to drive expression of inflammatory genes. Read More

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http://dx.doi.org/10.4049/jimmunol.1801436DOI Listing
February 2019
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Timing of Abatacept Before Elective Arthroplasty and Risk of Post-operative Outcomes.

Arthritis Care Res (Hoboken) 2019 Feb 11. Epub 2019 Feb 11.

University of Alabama at Birmingham, Division of Clinical Immunology and Rheumatology.

Objectives: Guidelines recommend holding biologic therapies before hip and knee arthroplasty, yet evidence to inform optimal timing is limited. We aimed to determine whether holding abatacept infusions is associated with lower risk of adverse post-operative outcomes.

Methods: This retrospective cohort study using U. Read More

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http://doi.wiley.com/10.1002/acr.23843
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http://dx.doi.org/10.1002/acr.23843DOI Listing
February 2019
4 Reads
4.713 Impact Factor

Inflammatory arthritis and Mycobacterium Tuberculosis infection: a diagnostic and management challenge for Knee arthroplasty in endemic areas.

J Pak Med Assoc 2019 02;69(Suppl 1)(1):S101-S107

Department of Surgery, Section of Orthopaedics, The Aga Khan University, Karachi Pakistan.

Tuberculosis continues to be one of the most challenging health problems more prevalent in developing countries. Pakistan ranks 5th in tuberculosis prevalence among the high-burden countries. Prosthetic joint infection of the knee by acid fast bacilli is a rare and distressing complication, occurring in nearly 1% of primary joint arthroplasties requiring prolonged medical treatment and multiple surgeries. Read More

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February 2019
1 Read
0.403 Impact Factor

Chronic hepatitis B viral infection among RA patients-a cross-sectional control study.

Clin Rheumatol 2019 Feb 8. Epub 2019 Feb 8.

Department of Medicine 'B', Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, 52621, Tel-Hashomer, Israel.

Background And Objectives: Rheumatoid arthritis (RA) is the most common inflammatory joint disorder presenting also with extra-articular manifestations. As many other autoimmune diseases, it has been suggested that infectious diseases might contribute to its emergence. Hepatitis viruses were suggested by several reports as a trigger of RA onset. Read More

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http://link.springer.com/10.1007/s10067-019-04448-x
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http://dx.doi.org/10.1007/s10067-019-04448-xDOI Listing
February 2019
5 Reads

Pyogenic sacroiliitis in children: don't forget the very young.

Eur J Pediatr 2019 Feb 7. Epub 2019 Feb 7.

Department of Pediatrics, Mount Scopus Hadassah-Hebrew University Medical Center, 91120, Jerusalem, Israel.

Pyogenic sacroiliitis (PS) is rare with less than 100 pediatric cases reported in the medical literature. To better characterize PS in the pediatric population, we investigated a series of children presenting with PS. Retrospective data analysis was done at an academic tertiary center between the years of 2000 and 2017. Read More

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http://dx.doi.org/10.1007/s00431-019-03333-8DOI Listing
February 2019
2 Reads