25,628 results match your criteria Viral Arthritis


Factors impacting severe disease from chikungunya infection: Prioritizing chikungunya vaccine when available.

Travel Med Infect Dis 2022 Jun 22:102391. Epub 2022 Jun 22.

Weill Cornell Medicine, New York, NY, USA; The New York Center for Travel and Tropical Medicine, New York, NY, USA.

View Article and Full-Text PDF

Comparative genomic analysis of Canadian Mycoplasma bovis strains isolated from Bison and Cattle.

Comp Immunol Microbiol Infect Dis 2022 Jun 8;87:101835. Epub 2022 Jun 8.

Vaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, 120 Veterinary Rd, Saskatoon, SK S7N 5E3, Canada.

Mycoplasma bovis (M. bovis) in cattle causes pneumonia, arthritis, otitis media, and mastitis. In addition, multiple outbreaks have been recorded in North American bison. Read More

View Article and Full-Text PDF

TREM-2 plays a protective role in cholestasis by acting as a negative regulator of inflammation.

J Hepatol 2022 Jun 21. Epub 2022 Jun 21.

Department of Liver and Gastrointestinal Diseases, Biodonostia Research Institute, Donostia University Hospital, University of the Basque Country (UPV-EHU), Donostia-San Sebastian, Spain; CIBERehd, Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Department of Medicine, Faculty of Medicine and Nursing, University of the Basque Country, UPV/EHU, Leioa, Spain. Electronic address:

Background & Aims: Cholestatic liver injury triggers a wound healing response orchestrated by Kupffer cells (KCs), hepatic stellate cells (HSCs) and other immune cells that leads to peribiliary fibrosis and disease progression. Inflammation is central, particularly that mediated by bacterial components translocating from the gut to the liver, binding to toll-like receptors (TLRs). The triggering receptor expressed on myeloid cells-2 (TREM-2) inhibits TLR-mediated signaling and exerts a protective role in hepatocellular injury and carcinogenesis. Read More

View Article and Full-Text PDF

The Prevalence of Histopathological Features of Pneumonia in Goats with Symptomatic Caprine Arthritis-Encephalitis.

Pathogens 2022 May 30;11(6). Epub 2022 May 30.

Division of Veterinary Epidemiology and Economics, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGW, Nowoursynowska 159c, 02-776 Warsaw, Poland.

Chronic interstitial pneumonia (CIP) is a main pathology of sheep infected with small ruminant lentivirus (SRLV). Caprine arthritis-encephalitis (CAE) is caused by the same pathogen; however, the presence of CIP has been only occasionally reported in SRLV-infected goats. We carried out a cross-sectional study to determine the prevalence of histopathological lesions indicative of CIP in goats with symptomatic CAE, and to investigate whether CIP was associated with a higher prevalence of other types of pneumonia (purulent bronchopneumonia, fibrinous pleuropneumonia) or bacterial infections. Read More

View Article and Full-Text PDF

Distinguishing from Pyogenic Acute Septic Arthritis in Young Portuguese Children.

Microorganisms 2022 Jun 16;10(6). Epub 2022 Jun 16.

Pediatric Orthopedic Unit, Área de Pediatria, Hospital de Dona Estefânia, Centro Hospitalar Universitário Lisboa Central, 1169-050 Lisbon, Portugal.

(1) : We aim to identify clinical and laboratorial parameters to distinguish from pyogenic septic arthritis (SA). (2) : A longitudinal, observational, single-centre study of children < 5 years old with microbiological positive SA admitted to a paediatric hospital from 2013-2020 was performed. Clinical and laboratorial data at admission and at 48 h, as well as on treatment and evolution, were obtained. Read More

View Article and Full-Text PDF

Synergistic Antiviral Activity of Pamapimod and Pioglitazone against SARS-CoV-2 and Its Variants of Concern.

Int J Mol Sci 2022 Jun 20;23(12). Epub 2022 Jun 20.

Institute of Virology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.

The SARS-CoV-2 pandemic remains a major public health threat, especially due to newly emerging SARS-CoV-2 Variants of Concern (VoCs), which are more efficiently transmitted, more virulent, and more able to escape naturally acquired and vaccine-induced immunity. Recently, the protease inhibitor Paxlovid and the polymerase inhibitor molnupiravir, both targeting mutant-prone viral components, were approved for high-risk COVID-19 patients. Nevertheless, effective therapeutics to treat COVID-19 are urgently needed, especially small molecules acting independently of VoCs and targeting genetically stable cellular pathways which are crucial for viral replication. Read More

View Article and Full-Text PDF

Potential Therapeutic Candidates against Discovered and Developed In Silico Using Core Proteomics and Molecular Docking and Simulation-Based Approaches.

Int J Environ Res Public Health 2022 Jun 15;19(12). Epub 2022 Jun 15.

Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk 71491, Saudi Arabia.

a species of the Chlamydiacea, is a leading cause of pneumonia. Failure to eradicate can lead to chronic infection, which is why it is also considered responsible for chronic inflammatory disorders such as asthma, arthritis, etc. There is an urgent need to tackle the major concerns arising due to persistent infections caused by as no FDA-approved drug is available against this chronic infection. Read More

View Article and Full-Text PDF

COVLIAS 2.0-cXAI: Cloud-Based Explainable Deep Learning System for COVID-19 Lesion Localization in Computed Tomography Scans.

Diagnostics (Basel) 2022 Jun 16;12(6). Epub 2022 Jun 16.

Vascular Screening and Diagnostic Centre, University of Nicosia Medical School, Engomi 2408, Cyprus.

Background: The previous COVID-19 lung diagnosis system lacks both scientific validation and the role of explainable artificial intelligence (AI) for understanding lesion localization. This study presents a cloud-based explainable AI, the "COVLIAS 2.0-cXAI" system using four kinds of class activation maps (CAM) models. Read More

View Article and Full-Text PDF

Global, regional, and national burden of hepatitis B, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019.

Authors:

Lancet Gastroenterol Hepatol 2022 Jun 20. Epub 2022 Jun 20.

Background: Combating viral hepatitis is part of the UN Sustainable Development Goals (SDGs), and WHO has put forth hepatitis B elimination targets in its Global Health Sector Strategy on Viral Hepatitis (WHO-GHSS) and Interim Guidance for Country Validation of Viral Hepatitis Elimination (WHO Interim Guidance). We estimated the global, regional, and national prevalence of hepatitis B virus (HBV), as well as mortality and disability-adjusted life-years (DALYs) due to HBV, as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. This included estimates for 194 WHO member states, for which we compared our estimates to WHO elimination targets. Read More

View Article and Full-Text PDF

Systemic Juvenile Idiopathic Arthritis in two children; case report on clinical course, challenges in diagnosis and the role of FDG-PET/CT-scan.

Clin Case Rep 2022 Jun 13;10(6):e05900. Epub 2022 Jun 13.

Department of Paediatrics Dijklander Hospital Hoorn Hoorn The Netherlands.

Systemic juvenile idiopathic arthritis (sJIA, also called Still's disease) is a rare childhood auto-inflammatory disease with significant morbidity. This case report illustrates the clinical course and highlights diagnostic challenges. FDG-PET/CT imaging may be beneficial in the diagnostic process for some cases, in order to achieve rapid diagnosis and early treatment. Read More

View Article and Full-Text PDF

Pharmacological thromboprophylaxis as a risk factor for early periprosthetic joint infection following primary total joint arthroplasty.

Sci Rep 2022 Jun 22;12(1):10579. Epub 2022 Jun 22.

Department of Orthopaedics and Traumatology, Taipei Veterans General Hospital, No. 201, Sec 2, Shi-Pai Road, Taipei, 112, Taiwan.

Venous thromboembolism (VTE) prophylaxis has been suggested for patients who underwent total join arthroplasty (TJA). However, the morbidity of surgical site complications (SSC) and periprosthetic joint infection (PJI) has not been well evaluated. We aimed to evaluate the impact of VTE prophylaxis on the risk of early postoperative SSC and PJI in a Taiwanese population. Read More

View Article and Full-Text PDF

2022 American College of Rheumatology/American Association of Hip and Knee Surgeons Guideline for the Perioperative Management of Antirheumatic Medication in Patients With Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty.

J Arthroplasty 2022 Jun 17. Epub 2022 Jun 17.

University of Alabama at Birmingham and Veterans Affairs Medical Center, Birmingham, Alabama.

Objective: To develop updated American College of Rheumatology/American Association of Hip and Knee Surgeons guidelines for the perioperative management of disease-modifying medications for patients with rheumatic diseases, specifically those with inflammatory arthritis (IA) and those with systemic lupus erythematosus (SLE), undergoing elective total hip arthroplasty (THA) or elective total knee arthroplasty (TKA).

Methods: We convened a panel of rheumatologists, orthopedic surgeons, and infectious disease specialists, updated the systematic literature review, and included currently available medications for the clinically relevant population, intervention, comparator, and outcomes (PICO) questions. We used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology to rate the quality of evidence and the strength of recommendations using a group consensus process. Read More

View Article and Full-Text PDF

Anti-glutathione S-transferase omega 1-1 (GSTO1-1) antibodies are increased during acute and chronic inflammation in humans.

Clin Exp Immunol 2022 Jun 22. Epub 2022 Jun 22.

Department of Translational Research NTMC, University of Pisa, Italy.

Glutathione S-transferase omega-1 (GSTO1-1) is a cytosolic enzyme involved in the modulation of critical inflammatory pathways as well as in cancer progression. Auto-antibodies against GSTO1-1 were detected in serum of patients with esophageal squamous cell carcinoma and were proposed as potential biomarkers in the early detection of the disease. Our data demonstrate that anti-GSTO1-1 antibodies can be found also in different types of inflammatory diseases, such as autoimmune rheumatoid arthritis and infectious SARS-CoV-2 and trichinellosis. Read More

View Article and Full-Text PDF

Myeloid cell-specific deletion of Capns1 prevents macrophage polarization toward the M1 phenotype and reduces interstitial lung disease in the bleomycin model of systemic sclerosis.

Arthritis Res Ther 2022 Jun 21;24(1):148. Epub 2022 Jun 21.

Department of Dermatology, Zhongshan Hospital, Fudan University, Xuhui District, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.

Background: Calpains are a family of calcium-dependent thiol proteases that participate in a wide variety of biological activities. In our recent study, calpain is increased in the sera of scleroderma or systemic sclerosis (SSc). However, the role of calpain in interstitial lung disease (ILD) has not been reported. Read More

View Article and Full-Text PDF

Plants extracts from Cameroon pharmacopeia strongly inhibit the Chikungunya virus infection by targeting entry and replication steps.

J Ethnopharmacol 2022 Jun 18;296:115458. Epub 2022 Jun 18.

Infectious Disease Biology, Institute of Life Sciences, Nalco Square, Chandrasekharpur, 751023, Bhubaneswar, Odisha, India. Electronic address:

Ethnopharmacological Relevance: Cameroon is one of the sub-Saharan African countries affected by Chikungunya virus (CHIKV). With the absence of approved treatment, this disease represents globally a major public health concern. Several plants are traditionally used in Cameroon for the treatment of virus induced fever and arthralgia. Read More

View Article and Full-Text PDF

Symptomatic hypercalcaemia following the use of calcium sulfate beads in periprosthetic joint infections.

N Z Med J 2022 Jun 10;135(1556):124-126. Epub 2022 Jun 10.

Department of Orthopaedic Surgery, Canterbury District Health Board.

Calcium sulfate beads (CSBs) are used as a method of delivery of antibiotics in periprosthetic joint infections, non-union and chronic osteomyelitis.[[1-3]] Symptomatic hypercalcaemia can occur as a complication following the insertion of CSBs however it is rare and few cases have been reported.[[4-7]] The cause of hypercalcaemia is poorly understood. Read More

View Article and Full-Text PDF

Potential role of HBV DNA-induced CD8 T cell apoptosis in patients with systemic lupus erythematosus and rheumatoid arthritis.

J Int Med Res 2022 Jun;50(6):3000605221104760

Department of Microbiology, School of Basic Medical Sciences, Anhui Medical University, Hefei, China.

Objective: To investigate the potential role of hepatitis B virus (HBV) DNA-induced CD8 T cell apoptosis in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).

Methods: The activity and HBV seropositivity rates of patients with SLE and RA were determined. The proportions of T cell subgroups were detected by fluorescence-activated cell sorting. Read More

View Article and Full-Text PDF

Urticaria and angioedema in children and adolescents: diagnostic challenge.

Allergol Immunopathol (Madr) 2022 17;50(S Pt 1):17-29. Epub 2022 May 17.

Division of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, McGill University Health Centre, Montreal, Canada.

Urticaria diagnosis may be challenging in children since it can be triggered or related to numerous conditions. In this paper, we reviewed the main aspects regarding the diagnosis of urticaria in the pediatric population. Acute urticaria is often due to viral infections. Read More

View Article and Full-Text PDF

Variability in primary Sjögren's syndrome is driven by interferon alpha, and genetically associated with the class II HLA DQ locus.

Arthritis Rheumatol 2022 Jun 20. Epub 2022 Jun 20.

Department of Rheumatology, Strasbourg University Hospital, National Centre For Rare Systemic Autoimmune Diseases, CNRS UPR3572, Immunology, Immunopathology and Therapeutic Chemistry, Institute of Molecular and Cellular Biology, Strasbourg University, Strasbourg, France.

Objective: Primary Sjögren's syndrome (pSS) is the second most frequent systemic autoimmune disease affecting 0.1% of the general population. To characterize the molecular and clinical variability across pSS patients, we integrated transcriptomic, proteomic, cellular and genetic data with clinical phenotypes in a cohort of 351 pSS patients. Read More

View Article and Full-Text PDF

Rheumatoid arthritis: advances in treatment strategies.

Mol Cell Biochem 2022 Jun 21. Epub 2022 Jun 21.

Department of Research, Sir Ganga Ram Hospital, New Delhi, 110060, India.

Rheumatoid arthritis (RA) is characterised by severe joint and bone damage due to heightened autoimmune response at the articular sites. Worldwide annual incidence and prevalence rate of RA is 3 cases per 10,000 population and 1%, respectively. Several genetic and environmental (microbiota, smoking, infectious agents) factors contribute to its pathogenesis. Read More

View Article and Full-Text PDF

F-FDG and  Ga-FAPI PET/CT for the evaluation of periprosthetic joint infection and aseptic loosening in rabbit models.

BMC Musculoskelet Disord 2022 Jun 20;23(1):592. Epub 2022 Jun 20.

Department of Nuclear Medicine, The First Medical Centre, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, People's Republic of China.

Purpose: We built a joint replacement loosening model based on the original rabbit model of infection and evaluated the performance characteristics of F-FDG and  Ga-FAPI in evaluating infection and loosening.

Methods: After surgery, the rabbits were divided into four groups, with six individuals in the control group and 10 each in the aseptic loosening, S. aureus and S. Read More

View Article and Full-Text PDF

EULAR/PRES recommendations for vaccination of paediatric patients with autoimmune inflammatory rheumatic diseases: update 2021.

Ann Rheum Dis 2022 Jun 20. Epub 2022 Jun 20.

RITA, European Reference Networks, Brussels, Belgium.

Objectives: Recent insights supporting the safety of live-attenuated vaccines and novel studies on the immunogenicity of vaccinations in the era of biological disease-modifying antirheumatic drugs in paediatric patients with autoimmune/inflammatory rheumatic diseases (pedAIIRD) necessitated updating the EULAR recommendations.

Methods: Recommendations were developed using the EULAR standard operating procedures. Two international expert committees were formed to update the vaccination recommendations for both paediatric and adult patients with AIIRD. Read More

View Article and Full-Text PDF

Atypical B cells in chronic infectious diseases and systemic autoimmunity: puzzles with many missing pieces.

Curr Opin Immunol 2022 Jun 17;77:102227. Epub 2022 Jun 17.

Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA.

The world's struggle to contain the SARS-CoV-2 epidemic, primarily through vaccination, has highlighted the importance of better understanding the biology of B cells that participate in defense against infectious diseases, both acute and chronic. Here, we focus on a population of human B cells, termed atypical B cells (ABCs), that comprise a distinct B-cell lineage that differentiates from naive B cells in an interferon-γ-driven process, and are infrequent in healthy individuals but significantly expanded in chronic infectious diseases, including malaria, as well as in systemic autoimmune diseases such as systemic lupus erythematosus (SLE). Recent comparisons of ABCs by single-cell RNAseq provided evidence that ABCs in diverse chronic infectious diseases and in systemic autoimmune diseases are highly related and share common drivers of differentiation and expansion. Read More

View Article and Full-Text PDF

2022 American College of Rheumatology/American Association of Hip and Knee Surgeons Guideline for the Perioperative Management of Antirheumatic Medication in Patients With Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty.

Arthritis Rheumatol 2022 Jun 20. Epub 2022 Jun 20.

University of Alabama at Birmingham and Veterans Affairs Medical Center, Birmingham, Alabama.

Objective: To develop updated guidelines for the perioperative management of disease-modifying medications for patients with rheumatic diseases, specifically those with inflammatory arthritis (IA) and those with systemic lupus erythematosus (SLE), undergoing elective total hip arthroplasty (THA) or elective total knee arthroplasty (TKA).

Methods: We convened a panel of rheumatologists, orthopedic surgeons, and infectious disease specialists, updated the systematic literature review, and included currently available medications for the clinically relevant population, intervention, comparator, and outcomes (PICO) questions. We used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology to rate the quality of evidence and the strength of recommendations using a group consensus process. Read More

View Article and Full-Text PDF

A Pilot, Open-Label Study to Evaluate the Efficacy of Intra-Articular Administration of a Caninized TNF Receptor Fc Fusion Protein as a Treatment for Osteoarthritis-Associated Joint Pain.

Front Vet Sci 2022 2;9:836709. Epub 2022 Jun 2.

Translational Research in Pain (TRiP) Program, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, United States.

Tumor necrosis factor-α (TNF-α) is a potential target for osteoarthritis (OA) treatment. In several recent clinical studies in human OA, anti-TNF-α therapy showed promising results; however, these were open-label and based on patient-reported outcome measures. In this study, we developed a caninized TNF-α receptor-Fc (caTNFR-Fc) fusion protein and conducted a non-randomized, open-label, pilot study in dogs with OA using objectively measured ground reaction forces and activity. Read More

View Article and Full-Text PDF

PET/CT-Based Characterization of 18F-FDG Uptake in Various Tissues Reveals Novel Potential Contributions to Coronary Artery Disease in Psoriatic Arthritis.

Front Immunol 2022 2;13:909760. Epub 2022 Jun 2.

National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD, United States.

Background And Objectives: Psoriasis is a heterogeneous inflammatory disease that involves the skin, joints, liver, heart, and other organs. Psoriatic arthritis (PsA) is associated with cardiovascular disease (CVD), but the relative contributions of inflammatory and metabolic dysregulation to CVD are incompletely understood. We set out to discover novel potential contributors to CVD in PsA patients by comprehensively phenotyping a cohort of PsA patients using these advanced technologies. Read More

View Article and Full-Text PDF

2022 American College of Rheumatology/American Association of Hip and Knee Surgeons Guideline for the Perioperative Management of Antirheumatic Medication in Patients With Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty.

Arthritis Care Res (Hoboken) 2022 Jun 19. Epub 2022 Jun 19.

University of Alabama at Birmingham and Veterans Affairs Medical Center, Birmingham, Alabama.

Objective: To develop updated guidelines for the perioperative management of disease-modifying medications for patients with rheumatic diseases, specifically those with inflammatory arthritis (IA) and those with systemic lupus erythematosus (SLE), undergoing elective total hip arthroplasty (THA) or elective total knee arthroplasty (TKA).

Methods: We convened a panel of rheumatologists, orthopedic surgeons, and infectious disease specialists, updated the systematic literature review, and included currently available medications for the clinically relevant population, intervention, comparator, and outcomes (PICO) questions. We used the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology to rate the quality of evidence and the strength of recommendations using a group consensus process. Read More

View Article and Full-Text PDF

Supporting discovery and development of medical countermeasures for chemical injury to eye and skin.

Exp Eye Res 2022 Jun 15;221:109156. Epub 2022 Jun 15.

Department of Health and Human Services, National Institute of Allergy and Infectious Diseases/National Institutes of Health (NIAID/NIH), 5601 Fishers Lane, Bethesda, MD, 20892, United States. Electronic address:

Vesicants, from vesica (Latin for blister), can cause local and systemic toxicity. They include the chemotherapy drug nitrogen mustard and chemical warfare agents sulfur mustard, Lewisite, and phosgene oxime. These agents are commonly released in vapor form and consequently, eyes and skin are the most vulnerable. Read More

View Article and Full-Text PDF

Streptococcal and Staphylococcus aureus prosthetic joint infections: are they really different?

BMC Infect Dis 2022 Jun 17;22(1):555. Epub 2022 Jun 17.

Centre de Référence des Infections Ostéo-Articulaires Complexes, Groupe Hospitalier Diaconesses-Croix Saint-Simon, 125, rue d'Avron, 75020, Paris, France.

Background: Staphylococci and streptococci are the most frequent pathogens isolated from prosthetic joint infections (PJIs). The aim of this study was to analyze the outcome of streptococcal and methicillin-susceptible Staphylococcus aureus (MSSA) PJIs.

Methods: All monomicrobial streptococcal and MSSA PJIs managed in a French Referral Center (2010-2017) were sampled from the prospective PJIs cohort study. Read More

View Article and Full-Text PDF