23,061 results match your criteria Viral Arthritis


Septic arthritis of the temporomandibular joint in an unvaccinated adolescent.

BMJ Case Rep 2020 Jul 9;13(7). Epub 2020 Jul 9.

Department of Oral and Maxillofacial Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

Septic arthritis of the temporomandibular joint (TMJ) is a rare condition, particularly in the paediatric population. Our case involves a 15-year-old unvaccinated Amish man with acute pain and trismus of the TMJ. The diagnosis was reached after history, clinical examination, radiographic and laboratory examinations were performed. Read More

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http://dx.doi.org/10.1136/bcr-2020-235597DOI Listing

Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation.

Genome Biol 2020 Jul 9;21(1):168. Epub 2020 Jul 9.

The Jackson Laboratory for Mammalian Genetics, Bar Harbor, ME, USA.

Background: Gene disruption in mouse embryonic stem cells or zygotes is a conventional genetics approach to identify gene function in vivo. However, because different gene disruption strategies use different mechanisms to disrupt genes, the strategies can result in diverse phenotypes in the resulting mouse model. To determine whether different gene disruption strategies affect the phenotype of resulting mutant mice, we characterized Rhbdf1 mouse mutant strains generated by three commonly used strategies-definitive-null, targeted knockout (KO)-first, and CRISPR/Cas9. Read More

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http://dx.doi.org/10.1186/s13059-020-02086-0DOI Listing

Baricitinib, a drug with potential effect to prevent SARS-COV-2 from entering target cells and control cytokine storm induced by COVID-19.

Int Immunopharmacol 2020 Jul 1;86:106749. Epub 2020 Jul 1.

Department of Pharmacy, Wuxi People's Hospital Attached to Nanjing Medical University, Wuxi 214023, Jiangsu, China. Electronic address:

In December 2019, a novel coronavirus pneumonia (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) suddenly broke out in China and rapidly spread all over the world. Recently, a cell surface protein, known as angiotensin-converting enzyme II (ACE2), has been identified to be involved in receptor-mediated endocytosis for SARS-CoV-2 entry to the cells. Many studies have reported the clinical characteristics of COVID-19: sudden deterioration of disease around 1-2 weeks after onset; much lower level of lymphocytes, especially natural killer (NK) cells in peripheral blood; extremely high pro-inflammatory cytokines and C reactive protein (CRP). Read More

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http://dx.doi.org/10.1016/j.intimp.2020.106749DOI Listing

In vivo synthesis of bacterial amyloid curli contributes to joint inflammation during S. Typhimurium infection.

PLoS Pathog 2020 Jul 9;16(7):e1008591. Epub 2020 Jul 9.

Department of Microbiology and Immunology, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania, United States of America.

Reactive arthritis, an autoimmune disorder, occurs following gastrointestinal infection with invasive enteric pathogens, such as Salmonella enterica. Curli, an extracellular, bacterial amyloid with cross beta-sheet structure can trigger inflammatory responses by stimulating pattern recognition receptors. Here we show that S. Read More

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http://dx.doi.org/10.1371/journal.ppat.1008591DOI Listing

Epidemiological and clinical characteristics of bacteremic brucellosis.

J Int Med Res 2020 Jul;48(7):300060520936829

Department of Infectious Diseases, Tianjin Second People's Hospital, Tianjin, China.

Objective: To retrospectively investigate the epidemiological features, clinical manifestations and laboratory characteristics of bacteremic brucellosis.

Methods: Brucellosis patients admitted to our clinic from January 2015 to December 2017 were included in the study. Patient electronic medical records were reviewed for epidemiological features, clinical manifestations, and laboratory findings. Read More

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http://dx.doi.org/10.1177/0300060520936829DOI Listing

Curcumin: a Wonder Drug as a Preventive Measure for COVID19 Management.

Indian J Clin Biochem 2020 Jul 17;35(3):373-375. Epub 2020 Jun 17.

Central Research Laboratory, K. S. Hegde Medical Academy, Mangalore, 575018 India.

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http://dx.doi.org/10.1007/s12291-020-00902-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299138PMC

Analysis of the intricate effects of polyunsaturated fatty acids and polyphenols on inflammatory pathways in health and disease.

Food Chem Toxicol 2020 Jul 5:111558. Epub 2020 Jul 5.

Laboratory of Toxicology and Forensic Sciences, Medical School, University of Crete, 71003, Heraklion, Greece; Department of Analytical and Forensic Medical Toxicology, Sechenov University, 2-4 Bolshaya Pirogovskaya st, 119991, Moscow, Russia. Electronic address:

Prevention and treatment of non-communicable diseases (NCDs), including cardiovascular disease, diabetes, obesity, cancer, Alzheimer's and Parkinson's disease, arthritis, non-alcoholic fatty liver disease and various infectious diseases; lately most notably COVID-19 have been in the front line of research worldwide. Although targeting different organs, these pathologies have common biochemical impairments - redox disparity and, prominently, dysregulation of the inflammatory pathways. Research data have shown that diet components like polyphenols, poly-unsaturated fatty acids (PUFAs), fibres as well as lifestyle (fasting, physical exercise) are important factors influencing signalling pathways with a significant potential to improve metabolic homeostasis and immune cells' functions. Read More

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http://dx.doi.org/10.1016/j.fct.2020.111558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335494PMC

High tolerance to instrument drifts by differential chemical isotope labeling LC-MS: A case study of the effect of LC leak in long-term sample runs on quantitative metabolome analysis.

J Mass Spectrom 2020 Jun 11:e4589. Epub 2020 Jun 11.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Metabolomics study of a biological system often involves the analysis of many comparative samples over a period of several days or weeks. This process of long-term sample runs can encounter unexpected instrument drifts such as small leaks in liquid chromatography-mass spectrometry (LC-MS), degradation of column performance, and MS signal intensity change. A robust analytical method should ideally tolerate these instrumental drifts as much as possible. Read More

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http://dx.doi.org/10.1002/jms.4589DOI Listing

Gonococcal osteomyelitis in a pediatric patient with disseminated gonococcal infection: Implications for antimicrobial management.

IDCases 2020 18;21:e00875. Epub 2020 Jun 18.

Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, 500 Hofstra Blvd, Hempstead, New York, 11549, United States.

We report a case of a female teenager with gonococcal septic arthritis of the right shoulder that also caused osteomyelitis of the humeral head. Infection with is a frequently diagnosed sexually transmitted infection in the sexually active teenage population and disseminated gonococcal infection (DGI) is the most common systemic manifestation of acute gonorrhea. DGI commonly involves acute arthritis, tenosynovitis and dermatitis with less common complications of endocarditis, hepatitis and meningitis. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327928PMC

T Helper Plasticity Is Orchestrated by STAT3, Bcl6, and Blimp-1 Balancing Pathology and Protection in Malaria.

iScience 2020 Jun 24;23(7):101310. Epub 2020 Jun 24.

Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555-0435, USA; Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555-0435, USA. Electronic address:

Hybrid Th1/Tfh cells (IFN-γIL-21CXCR5) predominate in response to several persistent infections. In Plasmodium chabaudi infection, IFN-γ T cells control parasitemia, whereas antibody and IL-21Bcl6 T cells effect final clearance, suggesting an evolutionary driver for the hybrid population. We found that CD4-intrinsic Bcl6, Blimp-1, and STAT3 coordinately regulate expression of the Th1 master regulator T-bet, supporting plasticity of CD4 T cells. Read More

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http://dx.doi.org/10.1016/j.isci.2020.101310DOI Listing

Covid-19 related IgA vasculitis.

Arthritis Rheumatol 2020 Jul 6. Epub 2020 Jul 6.

Department of Virology, Hôpital Saint-Louis, APHP, Université de Paris, Paris, France.

IgA vasculitis is a systemic small-vessel vasculitis which may be triggered by different microorganisms. IgA vasculitis cases have been reported in patients with immune-mediated inflammatory disorders treated with TNF inhibitors. Here we report the case of a young Crohn's disease patient in clinical remission under adalimumab admitted for an IgA vasculitis, with an extended ileitis, and a positive PCR testing for Covid-19. Read More

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http://dx.doi.org/10.1002/art.41428DOI Listing

Response to: 'Comparative analysis of synovial inflammation after SARS-CoV-2 infection' by Alivernini .

Ann Rheum Dis 2020 Jul 6. Epub 2020 Jul 6.

Seccion de Reumatologia, Hospital General Universitario de Alicante, Alicante, Spain

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http://dx.doi.org/10.1136/annrheumdis-2020-218368DOI Listing

Prolonged presence of SARS-CoV-2 in a COVID-19 case with rheumatoid arthritis taking iguratimod treated with ciclesonide.

J Infect Chemother 2020 Jul 1. Epub 2020 Jul 1.

Department of Infectious Diseases, Internal Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8574, Japan; Department of Intelligent Network for Infection Control, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.

We report a coronavirus disease 2019 (COVID-19) case with rheumatoid arthritis taking iguratimod. The patient who continued iguratimod therapy without dose reduction was treated with ciclesonide had an uneventful clinical course, but prolonged detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was observed after resolution of symptoms. The effects of disease-modifying antirheumatic drugs (DMARDs) and ciclesonide on clinical course and viral shedding remain unknown and warrant further investigation. Read More

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http://dx.doi.org/10.1016/j.jiac.2020.06.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328613PMC

Nasal carriage of various staphylococcal species in small ruminant lentivirus-infected asymptomatic goats.

Pol J Vet Sci 2020 Jun;23(2):203-209

Division of Veterinary Epidemiology and Economics, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 159c, 02-776 Warsaw, Poland.

The study was carried out in Polish goat population to estimate the prevalence of the nasal cavity infection with various staphylococcal species including methicillin-resistant Staphylococcus aureus(MRSA), investigate the potential permissive role of small ruminant lentivirus (SRLV) infection and determine the level of clonality of S. aureus nasal isolates. Nasal swabs and blood samples were collec-ted from 1300 clinically healthy adult goats from 21 Polish goat herds. Read More

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http://dx.doi.org/10.24425/pjvs.2020.133634DOI Listing

Leprosy mimicking rheumatoid vasculitis with scleromalacia perforans.

BMJ Case Rep 2020 07 5;13(7). Epub 2020 Jul 5.

Department of Rheumatology, King George's Medical University, Lucknow, India.

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http://dx.doi.org/10.1136/bcr-2020-236796DOI Listing

Cutaneous manifestation of reactive arthritis.

Joint Bone Spine 2020 Jul 1. Epub 2020 Jul 1.

Department of dermatology, Besançon University hospital, Besançon, France. Electronic address:

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http://dx.doi.org/10.1016/j.jbspin.2020.06.010DOI Listing

Exudative Retinal Detachment in Ocular Inflammatory Diseases: Risk and Predictive Factors.

Am J Ophthalmol 2020 Jul 1. Epub 2020 Jul 1.

Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts; Department of Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts; MyungSung Christian Medical Center (MCM) Eye Unit, MCM General Hospital and MyungSung Medical School, Addis Ababa, Ethiopia.

Purpose: To evaluate the risk/risk factors for exudative retinal detachment (ERD) in ocular inflammatory diseases.

Design: Retrospective cohort study.

Methods: Patients with non-infectious ocular inflammation had been followed longitudinally between 1978-2007 at four US subspecialty uveitis centers. Read More

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http://dx.doi.org/10.1016/j.ajo.2020.06.019DOI Listing

species infections in humans: a systematic review.

J Chemother 2020 Jul 3:1-11. Epub 2020 Jul 3.

Department of Internal Medicine & Infectious Diseases, University Hospital of Heraklion, Heraklion, Greece.

species have been recognized to cause infections in immunocompromised individuals. The purpose of this study was to systemically review all published cases of infections in humans and describe the epidemiology, microbiology, antimicrobial susceptibility, treatment and outcomes of these infections in humans. We performed a systematic review of PubMed (through 20 Octrober 2019) for studies providing epidemiological, clinical, microbiological as well as treatment data and outcomes of species infections. Read More

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http://dx.doi.org/10.1080/1120009X.2020.1785742DOI Listing

Is there an association between long-term antibiotics for acne and subsequent infection sequelae and antimicrobial resistance? A systematic review protocol.

BMJ Open 2020 Jul 2;10(7):e033662. Epub 2020 Jul 2.

Department of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine Faculty of Epidemiology and Population Health, London, UK.

Introduction: Antimicrobial resistance (AMR) is a global health emergency. Acne vulgaris is a highly prevalent condition and the dominant role antibiotics play in its treatment is a major concern. Antibiotics are widely used in the treatment of acne predominantly for their anti-inflammatory effect, hence their use in acne may not be optimal. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-033662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333805PMC

Clinical and Genetic Study of X-linked Agammaglobulinemia Patients (The Benefit of Early Diagnosis).

Iran J Allergy Asthma Immunol 2020 Jun 23;19(3):305-309. Epub 2020 Jun 23.

Immunology, Asthma, and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

X-linked agammaglobulinemia (XLA) is a primary immunodeficiency caused by genetic defects in the Bruton tyrosine kinase (Btk) gene. XLA is characterized as an antibody deficiency by recurrent bacterial infections, the absence of peripheral B cells, and profound reductions in all immunoglobulin isotypes. This study aims to report the clinical and genetic features of five Iranian patients with XLA. Read More

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http://dx.doi.org/10.18502/ijaai.v19i3.3458DOI Listing

Combination treatment with secukinumab and dimethyl fumarate in a patient with psoriasis and recent diagnosis of multiple sclerosis.

Dermatol Ther 2020 Jul 2:e13943. Epub 2020 Jul 2.

Dermatology Unit; Surgical, Medical and Dental Department of Morphological Sciences related to Transplant, Oncology and Regenerative Medicine; University of Modena and Reggio Emilia, Modena, Italy.

The therapeutic approach to patients with psoriasis and concomitant multiple sclerosis is challenging. We report the clinical case of a 44-year-old man affected by psoriasis and psoriatic arthritis treated with secukinumab for 2 years, who received also dimethyl fumarate because of a recent diagnosis of relapsing remitting multiple sclerosis. Moreover, a mini-review of the available literature regarding the use of secukinumab in patients with psoriasis or ankylosing spondylitis and coexisting central nervous system demyelinating diseases was performed. Read More

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http://dx.doi.org/10.1111/dth.13943DOI Listing

Is it Kawasaki shock syndrome, Kawasaki-like disease or pediatric inflammatory multisystem disease? The importance of semantic in the era of COVID-19 pandemic.

RMD Open 2020 06;6(2)

Department of Clinical Sciences and Community Health, University of Milan, and ASST G. Pini, Milan, Italy.

A few weeks after the peak of the global 2019 novel coronavirus disease pandemic, cases of shock, multisystem inflammation and severe myocarditis have occurred in children and adolescents, generating some concerns and above all many questions. An almost immediate association raised with shock syndrome related to Kawasaki disease (KD). However, in light of bo/th experience and literature have taught us about severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) infection, and what already known on the epidemiology of KD, we suggest here the hypothesis of a new 'post-viral' systemic inflammatory disease related to excessive adaptive immune response rather than a form of KD caused by SARS-COV-2. Read More

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http://dx.doi.org/10.1136/rmdopen-2020-001333DOI Listing

Hydroxychloroquine for COVID-19: What is our Current State of Knowledge?

J Assoc Physicians India 2020 Jun;68(6):48-52

Dean, Indian College of Physicians; Consultant Endocrinologist, Lilavati and Bhatia Hospital, Mumbai, Maharashtra.

Chloroquine and Hydroxychloroquine are drugs which have been widely used in malaria and rheumatoid arthritis respectively for over 50 years. There was anecdotal evidence of their efficacy in the earlier SARS outbreak in 2003. This prompted physicians from across the world to use them in the present SARS-CoV- 2 pandemic that is currently sweeping the globe, with 5 million people already infected to date. Read More

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[Endogenous endophtalmitis in a patient withStaphylococcus aureusbacteraemia].

Ned Tijdschr Geneeskd 2020 May 28;164. Epub 2020 May 28.

LUMC, afd. Interne Geneeskunde, Leiden.

Background: Staphylococcus aureas bacteraemia can spread to cause endocartitis, spondylodiscitis or infection of vascular or joint prostheses. Endogenous endophtalmitis is a serious complication which may result in permanent visual loss of the affected eye. Treatment consists of intra-ocular injection of antibiotics or a vitrectomy. Read More

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A case of asthma with Behcet's disease: successful treatment with omalizumab and its effects on recurrent aphthous lesions.

Immunopharmacol Immunotoxicol 2020 Jul 7:1-4. Epub 2020 Jul 7.

Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Akdeniz University, Antalya, Turkey.

Context: Monoclonal antibody therapies have revolutionized the treatment of autoinflammatory-immune/genetic disease including spondylarthritis, asthma and rheumatoid arthritis. Behcet's disease (BD) is a multi-systemic vasculitis, which is generally recurrent aphthous lesions (RAL) as well as ocular and skin lesions. Today, the immunohistopathogenesis of BD is mostly unknown. Read More

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http://dx.doi.org/10.1080/08923973.2020.1789656DOI Listing

Are Leading Risk Factors for Cancer and Mental Disorders Multimorbidity Shared by These Two Individual Conditions in Community-Dwelling Middle-Aged Adults?

Cancers (Basel) 2020 Jun 26;12(6). Epub 2020 Jun 26.

Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, VIC 3002, Australia.

Data on the leading shared risk factors of cancer and mental disorders are limited. We included 98,958 participants (54.8% women) aged 45-64 years from the 45 and Up Study who were free of cancer, depression, and anxiety at baseline (2006-2009). Read More

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http://dx.doi.org/10.3390/cancers12061700DOI Listing

Extended clinical and immunological phenotype and transplant outcome in CD27 and CD70 deficiency.

Blood 2020 Jun 30. Epub 2020 Jun 30.

Ludwig Boltzmann Institute for Rare and Undagnosed Diseases, Austria.

Biallelic mutations in the genes encoding CD27 or its ligand CD70 underlie inborn errors of immunity characterized predominantly by EBV-associated immune dysregulation, such as chronic viremia, severe infectious mononucleosis, hemophagocytic lymphohistiocytosis (HLH), lymphoproliferation and malignancy. A comprehensive understanding of the natural history, immune characteristics and transplant outcomes has remained elusive. Here, in a multi-institutional global collaboration, we collected clinical information of 49 patients from 29 families (CD27 n=33, CD70 n=16), including 24 previously unreported individuals and identified a total of 16 distinct mutations in CD27, and 8 in CD70, respectively. Read More

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http://dx.doi.org/10.1182/blood.2020006738DOI Listing

Brief Report: Anti-phospholipid antibodies in critically ill patients with Coronavirus Disease 2019 (COVID-19).

Arthritis Rheumatol 2020 Jun 30. Epub 2020 Jun 30.

Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730.

Objectives: Coagulopathy is one of the characteristics of critically ill patients with Coronavirus Disease 2019 (COVID-19). Antiphospholipid antibodies (aPLs) contribute to coagulopathy, but their role in COVID-19 remains unclear. We aimed to determine the prevalence and characteristics of aPLs in patients with COVID-19. Read More

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http://dx.doi.org/10.1002/art.41425DOI Listing

Rapid image deconvolution and multiview fusion for optical microscopy.

Nat Biotechnol 2020 Jun 29. Epub 2020 Jun 29.

Laboratory of High-Resolution Optical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA.

The contrast and resolution of images obtained with optical microscopes can be improved by deconvolution and computational fusion of multiple views of the same sample, but these methods are computationally expensive for large datasets. Here we describe theoretical and practical advances in algorithm and software design that result in image processing times that are tenfold to several thousand fold faster than with previous methods. First, we show that an 'unmatched back projector' accelerates deconvolution relative to the classic Richardson-Lucy algorithm by at least tenfold. Read More

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http://dx.doi.org/10.1038/s41587-020-0560-xDOI Listing

Immunity to commensal skin fungi promotes psoriasiform skin inflammation.

Proc Natl Acad Sci U S A 2020 Jun 29. Epub 2020 Jun 29.

Metaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892;

Under steady-state conditions, the immune system is poised to sense and respond to the microbiota. As such, immunity to the microbiota, including T cell responses, is expected to precede any inflammatory trigger. How this pool of preformed microbiota-specific T cells contributes to tissue pathologies remains unclear. Read More

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http://dx.doi.org/10.1073/pnas.2003022117DOI Listing

Sex differences in neutrophil biology modulate response to type I interferons and immunometabolism.

Proc Natl Acad Sci U S A 2020 Jun 29. Epub 2020 Jun 29.

Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NIH, Bethesda, MD 20892;

Differences between female and male immunity may contribute to variations in response to infections and predisposition to autoimmunity. We previously reported that neutrophils from reproductive-age males are more immature and less activated than their female counterparts. To further characterize the mechanisms that drive differential neutrophil phenotypes, we performed RNA sequencing on circulating neutrophils from healthy adult females and males. Read More

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http://dx.doi.org/10.1073/pnas.2003603117DOI Listing

[Sjögren's syndrome with juvenile onset].

Ter Arkh 2019 May 15;91(5):54-60. Epub 2019 May 15.

V.A. Nasonova Scientific and Research Institute of Rheumatology, Pediatric Department.

Aim to analyze demographic data, clinical features and results of laboratory and instrumental examinations in children with primary and secondary Sjögren syndrome (SS).

Materials And Methods: The study included all consequently patients, who hospitalized to the pediatric department of V.A. Read More

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http://dx.doi.org/10.26442/00403660.2019.05.000189DOI Listing

Evaluation of Musculoskeletal and Pulmonary Bacterial Infections With [I]FIAU PET/CT.

Mol Imaging 2020 Jan-Dec;19:1536012120936876

The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Purpose: Imaging is limited in the evaluation of bacterial infection. Direct imaging of in situ bacteria holds promise for noninvasive diagnosis. We investigated the ability of a bacterial thymidine kinase inhibitor ([I]FIAU) to image pulmonary and musculoskeletal infections. Read More

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http://dx.doi.org/10.1177/1536012120936876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325456PMC

A77 1726, the active metabolite of the anti-rheumatoid arthritis drug leflunomide, inhibits influenza A virus replication in vitro and in vivo by inhibiting the activity of Janus kinases.

FASEB J 2020 Jun 29. Epub 2020 Jun 29.

College of Veterinary Medicine, Yangzhou University, Yangzhou, P.R. China.

The newly reassorted IAV subtypes from zoonotic reservoirs respond poorly to current vaccines and antiviral therapy. There is an unmet need in developing novel antiviral drugs for better control of IAV infection. The cellular factors that are crucial for virus replication have been sought as novel molecular targets for antiviral therapy. Read More

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http://dx.doi.org/10.1096/fj.201902793RRDOI Listing

Effect of Underlying Comorbidities on the Infection and Severity of COVID-19 in Korea: a Nationwide Case-Control Study.

J Korean Med Sci 2020 Jun 29;35(25):e237. Epub 2020 Jun 29.

Artificial Intelligence and Big-Data Convergence Center, Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.

Background: The coronavirus disease 2019 (COVID-19) pandemic is an emerging threat worldwide. It remains unclear how comorbidities affect the risk of infection and severity of COVID-19.

Methods: This is a nationwide retrospective case-control study of 219,961 individuals, aged 18 years or older, whose medical costs for COVID-19 testing were claimed until May 15, 2020. Read More

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http://dx.doi.org/10.3346/jkms.2020.35.e237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324262PMC

Association between proton pump inhibitors use and risk of hip fracture: A general population-based cohort study.

Bone 2020 Jun 25:115502. Epub 2020 Jun 25.

Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

Previous studies comparing risk of fracture among Proton Pump Inhibitors (PPIs) users with that among non-users were susceptible to confounding by indication. Epidemiologic studies of this association using an active medication as a comparator would appropriately address this bias. We conducted a propensity-score matched cohort study to compare the risk of incident fracture over five years among initiators of PPIs with initiators of histamine 2 receptor antagonist (H2RA) using data collected from The Health Improvement Network (THIN) database in the United Kingdom (2000-2016). Read More

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http://dx.doi.org/10.1016/j.bone.2020.115502DOI Listing

Case of acute arthritis following SARS-CoV-2 infection.

Ann Rheum Dis 2020 Jun 26. Epub 2020 Jun 26.

Department of Pathology, National Institute of Infectious Diseases, Shinjuku-ku, Tokyo, Japan.

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http://dx.doi.org/10.1136/annrheumdis-2020-218281DOI Listing

Pneumonia vaccination timing in relation to starting conventional synthetic disease-modifying antirheumatic drugs in patients with rheumatoid arthritis.

Ann Rheum Dis 2020 Jun 26. Epub 2020 Jun 26.

Centre for Epidemiology Versus Arthritis, The University of Manchester, Manchester, Manchester, UK.

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http://dx.doi.org/10.1136/annrheumdis-2020-217255DOI Listing

Correction to: Prime-boost vaccination strategy enhances immunogenicity compared to single pneumococcal conjugate vaccination in patients receiving conventional DMARDs, to some extent in abatacept but not in rituximab-treated patients.

Arthritis Res Ther 2020 Jun 26;22(1):162. Epub 2020 Jun 26.

Department of Clinical Sciences Lund, Section for Rheumatology, Lund University, Lund and Skåne University Hospital, Lund, Sweden.

An amendment to this paper has been published and can be accessed via the original article. Read More

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http://dx.doi.org/10.1186/s13075-020-02256-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318464PMC

Prevalence, incidence and epidemiology of childhood uveitis.

Acta Ophthalmol 2020 Jun 26. Epub 2020 Jun 26.

Department of Ophthalmology, Oulu University Hospital, Oulu, Finland.

Purpose: To analyse the prevalence, incidence and aetiology of paediatric uveitis.

Methods: A retrospective, population-based cohort study of Finnish children with uveitis in Northern Ostrobothnia Hospital District in 2008-2017. The data included parameters for age, gender, age at diagnosis, laterality, chronicity, anatomical distribution of the disease, aetiology and systemic association. Read More

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http://dx.doi.org/10.1111/aos.14535DOI Listing

The relationship between cancer and medication exposure in patients with systemic lupus erythematosus: a nested case-control study.

Arthritis Res Ther 2020 Jun 26;22(1):159. Epub 2020 Jun 26.

Department of Infectious Disease, The First Affiliated Hospital of Zhengzhou University, No. 1, Jianshe East Road, Zhengzhou, 450052, Henan Province, China.

Background: Systemic lupus erythematosus (SLE) is associated with increased risk of cancer and the mechanism remains unclear. Here, we examined the level of auto-antibodies and disease activity index scores in SLE patients with cancers and analyzed whether medications for SLE management might contribute to the higher cancer risk in SLE patients.

Methods: In this retrospective study, we carried out a nested case-control study in a large cohort of SLE patients. Read More

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http://dx.doi.org/10.1186/s13075-020-02228-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318532PMC

Infectious Triggers in Periodontitis and the Gut in Rheumatoid Arthritis (RA): A Complex Story About Association and Causality.

Front Immunol 2020 3;11:1108. Epub 2020 Jun 3.

Department for Rheumatology, Immunology and Allergology, Inselspital-University Hospital of Bern, Bern, Switzerland.

Rheumatoid arthritis (RA) is a systemic immune mediated inflammatory disease of unknown origin, which is predominantly affecting the joints. Antibodies against citrullinated peptides are a rather specific immunological hallmark of this heterogeneous entity. Furthermore, certain sequences of the third hypervariable region of human leukocyte antigen (HLA)-DR class II major histocompatibility (MHC) molecules, the so called "shared epitope" sequences, appear to promote autoantibody positive types of RA. Read More

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http://dx.doi.org/10.3389/fimmu.2020.01108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283532PMC

Streptococcus suis in Swedish grower pigs: occurrence, serotypes, and antimicrobial susceptibility.

Acta Vet Scand 2020 Jun 24;62(1):36. Epub 2020 Jun 24.

Department of Clinical Sciences, Swedish University of Agricultural Sciences (SLU), Box 7054, 750 07, Uppsala, Sweden.

Background: Streptococcus suis is a major cause of meningitis, arthritis, and pneumonia in pigs worldwide, and an emerging pathogen in humans. In Sweden, S. suis has previously received little attention but has in recent years become increasingly recognized as affecting the pig production. Read More

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http://dx.doi.org/10.1186/s13028-020-00533-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315512PMC

Serology confirms SARS-CoV-2 infection in PCR-negative children presenting with Paediatric Inflammatory Multi-System Syndrome.

medRxiv 2020 Jun 7. Epub 2020 Jun 7.

Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, B15 2TT, U.K.

Background: During the COVID-19 outbreak, reports have surfaced of children who present with features of a multisystem inflammatory syndrome with overlapping features of Kawasaki disease and toxic shock syndrome - Paediatric Inflammatory Multisystem Syndrome- temporally associated with SARS-CoV-2 pandemic (PIMS-TS). Initial reports find that many of the children are PCR-negative for SARS-CoV-2, so it is difficult to confirm whether this syndrome is a late complication of viral infection in an age group largely spared the worst consequences of this infection, or if this syndrome reflects enhanced surveillance.

Methods: Children hospitalised for symptoms consistent with PIMS-TS between 28 April and 8 May 2020, and who were PCR-negative for SARS-CoV-2, were tested for antibodies to viral spike glycoprotein using an ELISA test. Read More

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http://dx.doi.org/10.1101/2020.06.05.20123117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302282PMC

Musculoskeletal Disorders due to Chikungunya Virus: A Real Experience in a Rheumatology Department in Neiva, Huila.

Reumatol Clin 2020 Jun 20. Epub 2020 Jun 20.

Instituto de Evaluación Tecnológica en Salud (IETS), Bogotá, Colombia.

Background: Chikungunya (CHIKV), is an endemic RNA virus in some regions of Asia and Africa. In Colombia in 2014, its spread starts explosively and quickly. The presentation of CHIKV is a febrile condition, with musculoskeletal symptoms, which can progress to erosive arthropathy and polyarticular deformity. Read More

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http://dx.doi.org/10.1016/j.reuma.2020.04.002DOI Listing

Fungal arthritis with adjacent osteomyelitis caused by Candida pelliculosa: a case report.

BMC Infect Dis 2020 Jun 22;20(1):438. Epub 2020 Jun 22.

Vaccine Bio Research Institute, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Background: Candida sp. osteoarticular infection is rare and most often due to hematogenous seeding during an episode of candidemia in immunocompromised patients. However, the diagnosis can be delayed in patients with subtle symptoms and signs of joint infection without a concurrent episode of candidemia. Read More

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http://dx.doi.org/10.1186/s12879-020-05171-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310117PMC

Andrographolide attenuates complete freund's adjuvant induced arthritis via suppression of inflammatory mediators and pro-inflammatory cytokines.

J Ethnopharmacol 2020 Jun 20;261:113022. Epub 2020 Jun 20.

Defence Institute of Physiology & Allied Sciences, Lucknow Road, Timarpur, Delhi, 110054, India. Electronic address:

Ethnopharmacological Relevance: Traditional plant-derived medicines have enabled the mankind in curing the wide spectrum of diseases throughout the ages. Andrographis paniculata (Burm.f. Read More

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http://dx.doi.org/10.1016/j.jep.2020.113022DOI Listing

Challenges to scientific publishing in times of COVID-19.

Authors:
Mohit Goyal

J R Coll Physicians Edinb 2020 06;50(2):207-214

Division of Rheumatology, CARE Pain & Arthritis Centre, Goyal Hospital, Udaipur, India, Email:

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http://dx.doi.org/10.4997/JRCPE.2020.235DOI Listing

Increased serum levels of galectin-9 in patients with chikungunya fever.

Virus Res 2020 Jun 18;286:198062. Epub 2020 Jun 18.

Programa de Pós-Graduação em Inovação Terapêutica (PPGIT)/ UFPE, Brazil; Núcleo de Pesquisa em Inovação Terapêutica - Sueli Galdino (Nupit-SG), Brazil.

Chikungunya fever (CHIKF) is an arboviral disease that has caused an epidemic burst of chronic inflammatory joint disease in Latin America in the last few years. Efforts are being spent in understanding the mechanisms by which it may cause such articular damage and in determining possible biomarkers of the disease. Galectins (GAL) are a family of animal lectins with an affinity for beta-galactosides. Read More

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http://dx.doi.org/10.1016/j.virusres.2020.198062DOI Listing

Chloroquine in controlling biological infections.

Pol Merkur Lekarski 2020 Jun;48(285):199-203

Mazovian Center of Rehabilitation STOCER, Konstancin-Jeziorna, Poland.

From the middle of the 17th century, Cinchona tree's bark, which contains quinine, was used as an anti-malarial agent. It wasn't until the midtwentieth century that chloroquine was synthesized, followed by its further derivatives. Chloroquine inhibits protozoan polymerase activity, leading to an increase in heme, which is toxic to Plasmodium. Read More

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