21,305 results match your criteria Viral Arthritis


Impact of Porphyromonas gingivalis Peptidylarginine Deiminase on Bacterial Biofilm Formation, Epithelial Cell Invasion, and Epithelial Cell Transcriptional Landscape.

Sci Rep 2018 Sep 20;8(1):14144. Epub 2018 Sep 20.

Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, N-5021, Bergen, Norway.

Peptidylarginine deiminase (PPAD) is a virulence factor unique to pathogenic Porphyromonas species, especially P. gingivalis. Mechanistically, PPAD activity, in conjunction with Arg-specific gingipains, generates protein fragments with citrullinated C-termini. Read More

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September 2018

Genetic variant in IL-32 is associated with the ex vivo cytokine production of anti-TNF treated PBMCs from rheumatoid arthritis patients.

Sci Rep 2018 Sep 19;8(1):14050. Epub 2018 Sep 19.

Department of Internal Medicine, Radboud Centre for Infectious Diseases (RCI) and Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

About 60% of RA patients don't achieve good response with biological disease-modifying anti-rheumatic drugs bDMARD treatment (including TNF inhibitors, TNFi's). Previously, a link between TNFα and interleukin (IL)-32 was reported in RA. However, the exact mechanism linking IL-32 to response to treatment as not been studied yet. Read More

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September 2018

Three Multicenter, Randomized, Double-Blind, Placebo-Controlled Studies Evaluating the Efficacy and Safety of Ustekinumab in Axial Spondyloarthritis.

Arthritis Rheumatol 2018 Sep 18. Epub 2018 Sep 18.

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

Objectives: The efficacy and safety of ustekinumab were evaluated in 3 randomized, placebo-controlled studies in patients with axial spondyloarthritis (axSpA). The first 2 studies included patients with radiographic axSpA (Study 1 [anti-tumor necrosis factor (TNF)-naïve]; Study 2 [anti-TNF refractory]), and Study 3 patients had non-radiographic axSpA.

Methods: In all 3 studies, patients were randomly assigned (1:1:1) to receive subcutaneous ustekinumab 45mg or 90mg or placebo up to 24 weeks, after which placebo-treated patients were rerandomized to receive ustekinumab 45mg or 90mg. Read More

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September 2018

MR Imaging of Joint Infection and Inflammation with Emphasis on Dynamic Contrast-Enhanced MR Imaging.

PET Clin 2018 Oct 17;13(4):523-550. Epub 2018 Aug 17.

Department of Radiology, Boston University School of Medicine, Boston, MA, USA.

Contrast-enhanced MR imaging (CE-MR imaging) is recommended for diagnosis and monitoring of infectious and most inflammatory joint diseases. CE-MR imaging clearly differentiates soft and bony tissue from fluid collections and infectious debris. To improve imaging information, a dynamic CE-MR imaging sequence (DCE-MR imaging) sequence can be applied using fast T1-weighted sequential image acquisition during contrast injection. Read More

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October 2018

Inflammatory disorders associated with trisomy 8-myelodysplastic syndromes: French retrospective case-control study.

Eur J Haematol 2018 Sep 15. Epub 2018 Sep 15.

Department of Internal Medicine, Inflammation-Immunopathology-Biotherapy Department (DHU i2B), Assistance Publique - Hôpitaux de Paris, Hôpital Saint-Antoine, 184, rue du Faubourg Saint-Antoine, 75012 Paris, France UPMC University, Paris 06, Paris, France.

Objective: We report cases of myelodysplastic syndrome/myeloproliferative neoplasms (MDS/MPN) with trisomy 8 associated with inflammatory and autoimmune diseases (IADs).

Method: Data for 21 patients with trisomy 8-MDS/MPN and IADs were analyzed and compared to 103 patients with trisomy 8-MDS/MPN without IADs.

Results: The median age of MDS/MPN patients with IADs was 67 [59-80]. Read More

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September 2018
3 Reads

Robust interferon signature and suppressed tissue repair gene expression in synovial tissue from patients with post-infectious, Borrelia burgdorferi-induced Lyme arthritis.

Cell Microbiol 2018 Sep 14:e12954. Epub 2018 Sep 14.

Center for Immunology & Inflammatory Diseases, Division of Rheumatology, Allergy, & Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

In most patients with Lyme arthritis (LA), antibiotic therapy results in Borrelia burgdorferi pathogen elimination, tissue repair, and return to homeostasis. However, despite spirochetal killing, some patients develop proliferative synovitis, characterized by synovial hyperplasia, inflammation, vascular damage, and fibrosis that persists for months to several years after antibiotic treatment, called post-infectious LA. In this study, we characterized the transcriptomes of post-infectious LA patients' synovial tissue, the target tissue of the immune response. Read More

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September 2018

A case of acute septic arthritis of the hip joint caused by Panton-Valentine leukocidin-positive ST772 community-acquired methicillin-resistant Staphylococcus aureus.

J Infect Chemother 2018 Sep 11. Epub 2018 Sep 11.

Department of Microbiology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo, 192-0392, Japan.

Acute septic arthritis (ASA) caused by Staphylococcus aureus can lead to fulminant arthritis and cause permanent joint destruction. In particular, infection caused by methicillin-resistant Staphylococcus aureus (MRSA) becomes intractable and severe owing to limitation of therapeutic drugs. Here, we report the case of a young patient with ASA without any record of overseas travel, who was infected by the Panton-Valentine leukocidin-positive Bengal-Bay clone, which is a predominant community-acquired MRSA in India. Read More

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September 2018
1 Read

Vitis amurensis Rupr: A review of chemistry and pharmacology.

Phytomedicine 2018 Oct 17;49:111-122. Epub 2017 Aug 17.

Department of Pharmacy, School of Pharmaceutical Science, Xiamen University, Zhuang-jin Building, Rm253 Xiang'an South Road, Xiamen 361102, Fujian, China. Electronic address:

Purpose: Vitis amurensis Rupr. from the family Vitaceae, is a grape species native to the Asian continent. It is a highly attractive plant, used widely worldwide. Read More

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October 2018
1 Read

Spatial analyzes of HLA data in Rio Grande do Sul, south Brazil: genetic structure and possible correlation with autoimmune diseases.

Int J Health Geogr 2018 09 14;17(1):34. Epub 2018 Sep 14.

Instituto Nacional de Genética Médica Populacional (INaGeMP), Porto Alegre, Brazil.

Background: HLA genes are the most polymorphic of the human genome and have distinct allelic frequencies in populations of different geographical regions of the world, serving as genetic markers in ancestry studies. In addition, specific HLA alleles may be associated with various autoimmune and infectious diseases. The bone marrow donor registry in Brazil is the third largest in the world, and it counts with genetic typing of HLA-A, -B, and -DRB1. Read More

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September 2018
1 Read

Clinical & laboratory features of seventy-eight UK patients with Good's syndrome (thymoma & hypogammaglobulinemia).

Clin Exp Immunol 2018 Sep 14. Epub 2018 Sep 14.

Immunology, University of Manchester, Manchester University Hospitals NHS Trust, Manchester, United Kingdom.

Good's syndrome (thymoma and hypogammaglobulinemia) is a rare secondary immunodeficiency disease, previously reported in the published literature as mainly individual cases or small case series. We use the national UK-Primary Immune Deficiency (UKPID) registry to identify a large cohort of patients in the UK with this PID to review its clinical course, natural history and prognosis. Clinical information, laboratory data, treatment and outcome were collated and analysed. Read More

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September 2018
3 Reads

The role of dietary sodium on autoimmune diseases: The salty truth.

Autoimmun Rev 2018 Sep 11. Epub 2018 Sep 11.

Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases, Tel-Aviv University, Israel. Electronic address:

Autoimmune diseases are a group of heterogeneous condition that occur secondary to the intrinsic loss of tolerance to self- antigens. In genetically susceptible individuals, the complex interplay of environmental factors and epigenetic deregulations have been proposed to drive disease etiopathogenesis. Various environmental variables have been identified including viral infections, exposure to pollutants, stress and dietary factors. Read More

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September 2018
2 Reads

Fatal Chronic Active Epstein-Barr Virus Infection in a Rheumatoid Arthritis Patient Treated with Abatacept.

Intern Med 2018 Sep 12. Epub 2018 Sep 12.

The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.

Chronic active Epstein-Barr virus (CAEBV) T-cell type infection, systemic form, is characterized by persistent infectious mononucleosis-like symptoms, high EBV DNA levels in the peripheral blood, organ damage, and a poor prognosis. The association between CAEBV and rheumatoid arthritis (RA) is unclear. We report a case of fatal CAEBV T-cell type infection in an RA patient undergoing treatment with cytotoxic T-lymphocyte-associated antigen 4 immunoglobulin fusion protein (abatacept, ABT). Read More

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September 2018
1 Read

The use of biologic therapies in uveitis.

Rom J Ophthalmol 2018 Apr-Jun;62(2):105-113

"Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

Purpose: Non-infectious uveitis has been long controlled with the use of corticosteroids with many side effects and poor control in some cases. The purpose of this paper was to assess the different biologic agents (in this case infliximab and adalimumab) and to compare their efficacy in the treatment of uveitis.

Results: Adalimumab has been proven very successful in replacing or aiding corticosteroid therapy in different autoimmune mediated uveitis (Juvenile Idiopathic Arthritis, Rheumatoid arthritis, sarcoidosis) whereas infliximab has been used intravenously and recently intravitreally with very promising results in controlling Behcet's related uveitis. Read More

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September 2018
1 Read

Recurrent fevers, progressive lipodystrophy and annular plaques in a child.

J Am Acad Dermatol 2018 Sep 8. Epub 2018 Sep 8.

Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD. Electronic address:

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September 2018
2 Reads
4.45 Impact Factor

ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes.

Nat Commun 2018 Sep 10;9(1):3659. Epub 2018 Sep 10.

Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.

The HMG-CoA reductase degradation protein 1 (HRD1) has been identified as a key enzyme for endoplasmic reticulum-associated degradation of misfolded proteins, but its organ-specific physiological functions remain largely undefined. Here we show that mice with HRD1 deletion specifically in the liver display increased energy expenditure and are resistant to HFD-induced obesity and liver steatosis and insulin resistance. Proteomic analysis identifies a HRD1 interactome, a large portion of which includes metabolic regulators. Read More

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September 2018
4 Reads

Advances and challenges in targeting IRF5, a key regulator of inflammation.

FEBS J 2018 Sep 10. Epub 2018 Sep 10.

Kennedy Institute of Rheumatology, University of Oxford, UK.

Interferon regulatory factor 5 (IRF5) belongs to a family of transcription factors, originally implicated in antiviral responses and interferon production. However, studies conducted in different laboratories over the last decade have placed IRF5 as a central regulator of the inflammatory response. It has become clear that IRF5 contributes to the pathogenesis of many inflammatory and autoimmune diseases, such as rheumatoid arthritis, inflammatory bowel disease and systemic lupus erythematosus. Read More

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September 2018
2 Reads

Characteristics and Outcome of Twenty-Nine Implant-Related Infections of the Hand and Fingers: Results from a Twelve-Year Observational Study.

Surg Infect (Larchmt) 2018 Sep 7. Epub 2018 Sep 7.

2 Department of Infectious Diseases, Inselspital, Bern University Hospital, University of Bern , Bern, Switzerland .

Background: Implant-related infections in hand surgery are dreaded complications, potentially leading to loss of finger joint function or amputation. Knowledge about the clinical presentation and treatment concepts of these infections is limited. The aim of this study is to present a consecutive series of patients with implant-related infections of the finger joints and wrist. Read More

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September 2018
2 Reads

PD-1+CD8+ T cells are clonally expanding effectors in human chronic inflammation.

J Clin Invest 2018 Sep 10. Epub 2018 Sep 10.

Department of Pediatrics, Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands.

Chronic inflammatory diseases are characterized by recurrent inflammatory attacks in the tissues mediated by autoreactive T cells. Identity and functional programming of CD8+ T cells at the target site of inflammation still remain elusive. One key question is whether, in these antigen-rich environments, chronic stimulation leads to CD8+ T cell exhaustion comparable to what is observed in infectious disease contexts. Read More

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September 2018
3 Reads

Gene Delivery of Alpha-1-Antitrypsin Using Recombinant Adeno-Associated Virus (rAAV).

Methods Mol Biol 2018 ;1826:183-196

Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL, USA.

The challenge for alpha-1-antitrypsin (AAT also known as SERPINA1) gene therapy is to achieve long term and high levels of AAT production. Recombinant adeno-associated virus (rAAV) vector has several advantages for AAT gene delivery including no viral genes in the vector, no requirement of integration for long-term transgene expression, low immunogenicity, and wide tropism. AAV-mediated AAT gene therapy has been developed and tested in animal models for AAT deficiency, type 1 diabetes, rheumatoid arthritis, and osteoporosis. Read More

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January 2018
1 Read

In Vivo Analysis of Alpha-1-Antitrypsin Functions in Autoimmune Disease Models.

Methods Mol Biol 2018 ;1826:143-155

Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL, USA.

Alpha-1-antitrypsin (AAT) is a circulating protein, a serpin, with multiple protective functions. Beside the well-known proteinase inhibitory function, which protects the lungs from chronic obstructive pulmonary disease (COPD), many studies have shown that AAT inhibits pro-inflammatory cytokine gene expression and functions. These anti-inflammatory and immune-regulatory properties have led to studies testing the therapeutic effect of AAT in autoimmune disease models. Read More

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January 2018
2 Reads

[Rheumatoid arthritis-mimics : When appearances are deceptive].

Z Rheumatol 2018 Sep 6. Epub 2018 Sep 6.

Klinik für Rheumatologie und Klinische Immunologie, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Deutschland.

Rheumatology represents a discipline full of differential diagnoses. Even for classical diseases, such as rheumatoid arthritis as the most frequent chronic inflammatory joint disease and described so clearly in many textbooks, it is not uncommon that it can be a diagnostic challenge in daily practice. This applies to arthritic joint involvement and also to frequently associated extra-articular manifestations. Read More

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September 2018
1 Read

Serum Amyloid A Contributes to Chronic Apical Periodontitis via TLR2 and TLR4.

J Dent Res 2018 Sep 6:22034518796456. Epub 2018 Sep 6.

1 Department of Cariology, Restorative Sciences and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.

In the current concept of bacterial infections, pathogen-associated molecular patterns (PAMPs) derived from pathogens and damage-associated molecular patterns (DAMPs) released from damaged/necrotic host cells are crucial factors in induction of innate immune responses. However, the implication of DAMPs in apical and marginal periodontitis is unknown. Serum amyloid A (SAA) is a DAMP that is involved in the development of various chronic inflammatory diseases, such as rheumatoid arthritis. Read More

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September 2018
3 Reads

Bone and joint infections in infants under three months of age.

Acta Paediatr 2018 Sep 6. Epub 2018 Sep 6.

Paediatric Department-Division of infectious disease, Armand Trousseau Hospital, AP-HP, Paris, France.

Aim: Studies on bone and joint infections (BJI) in infants under three months are rare. We described the clinical and paraclinical features and outcomes of infants hospitalised with BJI under three months of age.

Methods: The French National Hospital Discharge Database provided data on BJIs in infants under three months of age from January 2004 to 2015 in three Parisian Paediatric teaching hospitals. Read More

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September 2018
3 Reads

Serological diagnostics of Lyme borreliosis: comparison of universal and species-specific tests based on whole-cell and recombinant antigens.

J Clin Microbiol 2018 Sep 5. Epub 2018 Sep 5.

Department of Biostatistics, National Institute of Public Health, Prague, Czech Republic.

The study compares diagnostic parameters of different commercial serological kits based on three different antigen types and correlates test results with the status of the patient's infection.In total, 8 IgM and 8 IgG kits were tested: ELISA (EUROIMMUN) based on whole-cell antigen, 3 species-specific EIAs (TestLine), LIAISON chemiluminescence (DiaSorin), ELISA-VIDITEST (Vidia), EIA and BLOT-LINE (TestLine) using recombinant antigens. All tests were performed on a panel of 90 samples from patients with clinically characterized borreliosis (53 x neuroborreliosis, 32 x erythema migrans, 5 x arthritis) plus 70 controls from blood donors and syphilis patients. Read More

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September 2018
1 Read

Tocilizumab and the risk of respiratory adverse events in patients with rheumatoid arthritis: a systematic review and meta-analysis of randomised controlled trials.

Clin Exp Rheumatol 2018 Aug 29. Epub 2018 Aug 29.

Department of Rheumatology and Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objectives: The purpose of this study is to evaluate the relative risk (RR) of respiratory adverse events (AEs) among patients with RA treated with TCZ.

Methods: Databases (PubMed, Embase and Cochrane Library) were searched for randomised controlled trials (RCT) comparing the use of TCZ with placebo (PBO) or active comparator agents in adults with RA published until October 28, 2017. Statistical analyses were conducted to calculate the RR of infectious and non-infectious respiratory AEs and severe AEs (SAEs) using random-effects or fixed-effects models based on the heterogeneity of the included studies. Read More

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August 2018
2 Reads

Managing cancer risk in patients with systemic lupus erythematous.

Expert Rev Clin Immunol 2018 Sep 14:1-10. Epub 2018 Sep 14.

d Division of Rheumatology , Cumming School of Medicine, University of Calgary , Calgary , AB , Canada.

Introduction: Numerous studies have clearly demonstrated that there is an altered cancer risk profile in patients with systemic lupus erythematous (SLE) versus the general population. This includes a higher risk of certain cancers (e.g. Read More

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September 2018
2 Reads

A case of Henoch-Schonlein Purpura with dilated coronary arteries.

Pediatr Rheumatol Online J 2018 Sep 4;16(1):54. Epub 2018 Sep 4.

Department of Pediatric Rheumatology, Children's Hospital Colorado, 13123 East 16th Avenue, B311, Aurora, CO, 80045, USA.

Background: Henoch-Schonlein Purpura (HSP) is one of the most common vasculitides of childhood, with 10-20 cases per 100,000 children. It frequently occurs following an infectious trigger and involves IgA and C3 deposition in small vessel walls. HSP is characterized by palpable purpura plus IgA deposition on biopsy, arthritis/arthralgia, renal involvement (hematuria and/or proteinuria), and/or abdominal pain. Read More

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September 2018
2 Reads

Outcomes of Shoulder Arthroplasty Performed for Postinfectious Arthritis.

Clin Orthop Surg 2018 Sep 22;10(3):344-351. Epub 2018 Aug 22.

The Rothman Institute of Orthopaedics, Thomas Jefferson University Hospitals, Philadelphia, PA, USA.

Background: The purpose of this study was to evaluate the functional outcomes, infection rate, and complications associated with shoulder arthroplasty for sequelae of prior septic arthritis.

Methods: This is a retrospective cohort study of 17 patients who underwent shoulder arthroplasty for sequelae of septic arthritis. Patients were analyzed for patient-reported outcomes, complications, and reoperations. Read More

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September 2018

Gut microbiota, cannabinoid system and neuroimmune interactions: New perspectives in multiple sclerosis.

Biochem Pharmacol 2018 Aug 30. Epub 2018 Aug 30.

Grupo de Neuroinmunología, Departamento de Neurobiología Funcional y de Sistemas, Instituto Cajal, CSIC, Madrid, Spain; Red Española de Esclerosis Múltiple (REEM), Spain. Electronic address:

The gut microbiota plays a fundamental role on the education and function of the host immune system. Immunological dysregulation is the cause of numerous human disorders such as autoimmune diseases and metabolic disorders frequently associated with inflammatory processes therefore is critical to explore novel mechanisms involved in maintaining the immune system homeostasis. The cannabinoid system and related bioactive lipids participate in multiple central and peripheral physiological processes that affect metabolic, gastrointestinal and neuroimmune regulatory mechanisms displaying a modulatory role and contributing to the maintenance of the organism's homeostasis. Read More

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August 2018
1 Read

Synthesis and evaluation of a novel water-soluble high Se-enriched Astragalus polysaccharide nanoparticles.

Int J Biol Macromol 2018 Oct 2;118(Pt B):1438-1448. Epub 2018 Jul 2.

Engineering Laboratory of Bio-Resource Eco-Utilization, Northeast Forestry University, Harbin 150040, China; Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, China.

Selenium is an essential trace element in human body. Se-deficiency is common phenomenon in all over the world, which severely harms the health of organism and causes the etiology of many chronic, degenerative diseases, such as atherosclerosis, arthritis, cancers, hypoimmunity, hypothyroidism and viral diseases. So, the research on preparation of Se-supplementing with the effective, safe and high Se content was imperative. Read More

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October 2018
2 Reads

Erosive Arthritis Resembling Osteomyelitis in Behcet's Disease.

J Coll Physicians Surg Pak 2018 Sep;28(9):719-720

Korea University College of Medicine, Seoul, Korea.

Erosive arthritis in Behcet's disease (BD) is rare and confused with infectious diseases such as osteomyelitis. Clinical course and imaging may be similar in BD-related arthritis and osteomyelitis. A 48-year woman diagnosed with BD developed recurrent pain in both feet. Read More

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September 2018
1 Read

How immunological profile drives clinical phenotype of primary Sjögren's syndrome at diagnosis: analysis of 10,500 patients (Sjögren Big Data Project).

Clin Exp Rheumatol 2018 May-Jun;36 Suppl 112(3):102-112. Epub 2018 Aug 14.

Sjögren Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, IDIBAPS-CELLEX, Department of Autoimmune Diseases, ICMiD, University of Barcelona, Hospital Clínic, Barcelona, Spain.

Objectives: To evaluate the influence of the main immunological markers on the disease phenotype at diagnosis in a large international cohort of patients with primary Sjögren's syndrome (SjS).

Methods: The Big Data Sjögren Project Consortium is an international, multicentre registry created in 2014. As a first step, baseline clinical information from leading centres on clinical research in SjS of the 5 continents was collected. Read More

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August 2018
11 Reads
2.72 Impact Factor

Identifying Common Pathogens in Periprosthetic Joint Infection and Testing Drug-resistance Rate for Different Antibiotics: A Prospective, Single Center Study in Beijing.

Orthop Surg 2018 Aug;10(3):235-240

Arthritis Clinic and Research Center, Peking University People's Hospital, Beijing, China.

Objective: The aim of this study is to identify the common microorganisms causing PJI as well as the drug-resistant spectrum for each microorganism, to help orthopaedic surgeons to choose appropriate antibiotics.

Method: One hundred and sixty patients who suffered from failure of primary or revision total hip or knee arthroplasty for different reasons were prospectively recruited. These patients underwent revision or re-revision total hip or knee arthroplasty in our institution between August 2013 to August 2016. Read More

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August 2018
2 Reads

Genetic control of alphavirus pathogenesis.

Mamm Genome 2018 Aug 27;29(7-8):408-424. Epub 2018 Aug 27.

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

Alphaviruses, members of the positive-sense, single-stranded RNA virus family Togaviridae, represent a re-emerging public health concern worldwide as mosquito vectors expand into new geographic ranges. Members of the alphavirus genus tend to induce clinical disease characterized by rash, arthralgia, and arthritis (chikungunya virus, Ross River virus, and Semliki Forest virus) or encephalomyelitis (eastern equine encephalitis virus, western equine encephalitis virus, and Venezuelan equine encephalitis virus), though some patients who recover from the initial acute illness may develop long-term sequelae, regardless of the specific infecting virus. Studies examining the natural disease course in humans and experimental infection in cell culture and animal models reveal that host genetics play a major role in influencing susceptibility to infection and severity of clinical disease. Read More

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August 2018
5 Reads

Characterization of new anti-IL-6 antibodies revealed high potency candidates for intracellular cytokine detection and specific targeting of IL-6 receptor binding sites.

Eur Cytokine Netw 2018 Jun;29(2):59-72

Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Aachen, Germany, Institute of Tropical Medicine, University of Tübingen, Wilhelmstraße 27, Tübingen, Germany.

Interleukin-6 (IL-6) expression and secretion, induced by inflammatory processes, stimulate the acute phase response cascade. The overexpression of IL-6 contributes to a variety of inflammatory diseases, e.g. Read More

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June 2018
3 Reads
1.96 Impact Factor

Hepatitis E during Tocilizumab Therapy in a Patient with Rheumatoid Arthritis: Case Report and Literature Review.

Case Rep Rheumatol 2018 26;2018:6873276. Epub 2018 Jul 26.

Department of Nephrology and Rheumatology, Gunma University Graduate School of Medicine, Maebashi, Japan.

Hepatitis E is an acute self-limiting disease caused by hepatitis E virus (HEV). Recent reports show that HEV can induce chronic hepatitis or be reactivated in immunocompromised hosts. We report a 63-year-old woman with rheumatoid arthritis (RA) who developed hepatitis E during treatment with tocilizumab. Read More

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July 2018
2 Reads

The Ethnopharmacological and Nutraceutical Relevance of (Willd.) Amin ex C. Jeffrey.

Evid Based Complement Alternat Med 2018 25;2018:7259146. Epub 2018 Jul 25.

Department of Pharmacology and Toxicology, School of Pharmacy, University of Ghana, Legon, Ghana.

(Willd.) Amin ex C. Jeffrey is a herb found mostly in tropical Africa. Read More

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July 2018
3 Reads

Attempting to remedy sub-optimal medication adherence in haemophilia: The rationale for repeated ultrasound visualisations of the patient's joint status.

Blood Rev 2018 Aug 20. Epub 2018 Aug 20.

Dipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Napoli "Federico II", Naples, Italy. Electronic address:

Haemophilia is marked by joint bleeding (haemarthrosis) leading to cartilage damage (arthropathy). Lifelong prophylaxis-initiated after the first bleeding episode-leads to a dramatic decrease in arthropathy in haemophilia patients. However, adherence to continuous intravenous administrations of factor VIII (FVIII) or FIX products is challenging, and patients potentially suffer from breakthrough bleedings while on prophylaxis. Read More

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August 2018
2 Reads

Two case reports of pyoderma gangrenosum and systemic lupus erythematosus: A rare but nonfortuitous association?

Medicine (Baltimore) 2018 Aug;97(34):e11933

Department of Internal Medicine, Clinical Immunology and Infectious Diseases, Robert Debré Hospital, University Hospital, Reims.

Rationale: Pyoderma gangrenosum (PG), like other neutrophilic dermatosis, may be associated with a variety of systemic disorders including inflammatory bowel diseases, rheumatoid arthritis, and hematologic disorders. Conversely, the association between PG and systemic lupus erythematosus (SLE) has rarely been reported.

Patient Concerns: We report here 2 cases of this association. Read More

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August 2018
3 Reads

Non-alcoholic steatohepatitis-like pattern in liver biopsy of rheumatoid arthritis patients with persistent transaminitis during low-dose methotrexate treatment.

PLoS One 2018 24;13(8):e0203084. Epub 2018 Aug 24.

Rheumatic and Collagen Disease Center, Sasebo Chuo Hospital, Sasebo, Nagasaki, Japan.

Objective: The mechanism of liver injury with low-dose methotrexate (MTX) is incompletely understood. This study was designed to evaluate the association between non-alcoholic fatty liver disease (NAFLD) and liver injury during MTX treatment for rheumatoid arthritis (RA).

Methods: Between October 2014 and May 2015, we enrolled all MTX users for RA and monitored participant serum hepatic transaminase levels for 1 year. Read More

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August 2018
2 Reads

Meningitis due to a Combination of and : A Case Report.

Case Rep Neurol 2018 May-Aug;10(2):177-180. Epub 2018 Jul 18.

Department of Neurology, Graduate School of Medicine and Dentistry, Okayama University, Okayama, Japan.

We report a rare case of meningitis due to a combination of and . An 80-year-old female had a 4-year history of type II diabetes mellitus (DM) and an 11-year history of rheumatoid arthritis, which was treated with prednisolone, tacrolimus, and methotrexate. One month after the removal of a dental implant, she complained of a disturbance of consciousness and suffered a convulsion. Read More

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July 2018
2 Reads

Differential expression of vitamin D associated genes in the aorta of coronary artery disease patients with and without rheumatoid arthritis.

PLoS One 2018 23;13(8):e0202346. Epub 2018 Aug 23.

Department of Research, Innlandet Hospital Trust, Brumunddal, Norway.

Background: Vitamin D has an important role in the immune system, and has been linked to rheumatoid arthritis (RA) and coronary artery disease (CAD). The exact mechanisms by which vitamin D is involved in these processes are still unclear. Therefore, we wanted to search for differences in expression of genes involved in the vitamin D receptor (VDR) activation pathway and genes that are known to alter upon vitamin D stimulation, in the aortic adventitia of CAD patients with and without RA. Read More

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August 2018
1 Read

Septic arthritis of native hip joint by Staphylococcus lugdunensis: a case report.

Rev Soc Bras Med Trop 2018 Jul-Aug;51(4):554-556

Internal Medicine Department, University of Alabama, Montgomery, Alabama, United States.

Staphylococcus lugdunensis is a rare virulent coagulase-negative staphylococcus (CoNS) that behaves similarly to Staphylococcus aureus in causing deep abscesses, skin and soft tissue infections, and central nervous system infections. Additionally, there can be certain blood stream infections including sepsis, septic shock, toxic shock syndrome, and endocarditis complicated by embolic events. Reports of septic arthritis of a native joint associated with this organism have been infrequent, justifying the presentation and discussion of this case. Read More

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September 2018
5 Reads

Postpartum Depression and Subsequent Autoimmune Diseases in Taiwan.

Int J Environ Res Public Health 2018 Aug 20;15(8). Epub 2018 Aug 20.

Department of Obstetrics & Gynecology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.

Postpartum depression (PPD) is one of the most common examples of postnatal morbidity, but the subsequent risks of autoimmune diseases in patients with PPD have yet to be fully investigated. This nationwide population-based study utilized data of the National Health Insurance Research Database of Taiwan for the period from 1996 to 2013. In total, 45,451 women with primiparity were identified. Read More

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August 2018
1 Read

Clinical Practice Guidance for Juvenile Idiopathic Arthritis (JIA) 2018.

Mod Rheumatol 2018 Aug 21:1-53. Epub 2018 Aug 21.

k Department of Lifetime Clinical Immunology , Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University , Tokyo , Japan.

Juvenile idiopathic arthritis (JIA) is the most common disease in pediatric rheumatism. There is no specific symptom or examination finding for JIA, and the diagnosis is made by exclusion and differentiation. Because non-pediatric rheumatologists are sometimes involved in medical care, "proposal for juvenile idiopathic arthritis guidance on diagnosis and treatment for primary care pediatricians and non-pediatric rheumatologists" was first published in 2007. Read More

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August 2018
5 Reads

Passive smoking in childhood increases the risk of developing rheumatoid arthritis.

Rheumatology (Oxford) 2018 Aug 14. Epub 2018 Aug 14.

Rhumatologie, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpitaux universitaires Paris-Sud - Hôpital Bicêtre, Le Kremlin Bicêtre, Paris, France.

Objectives: To investigate the link between smoking status, including childhood and adult passive exposure, and the risk of incident RA.

Methods: The French E3N cohort includes 98 995 female volunteers prospectively followed since 1990. Self-administered questionnaires sent every 2-3 years collected medical events, general, lifestyle and environmental characteristics. Read More

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August 2018
6 Reads

The use of biomarkers as a tool for novel psoriatic disease drug discovery.

Expert Opin Drug Discov 2018 Sep 20;13(9):875-887. Epub 2018 Aug 20.

d Department of Rheumatology , Hammersmith Hospital , London , UK.

Introduction: Psoriatic disease is a relatively new term which encompasses psoriatic arthritis, psoriasis, and associated comorbidities. In this heterogeneous condition, the study of biomarkers is necessary to direct best therapy. Resulting in significant disability and socioeconomic burden, recent recommendations stress the need for tight control in psoriatic disease. Read More

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September 2018
4 Reads

Systematic Analysis of Differential Expression Profile in Rheumatoid Arthritis Chondrocytes Using Next-Generation Sequencing and Bioinformatics Approaches.

Int J Med Sci 2018 13;15(11):1129-1142. Epub 2018 Jul 13.

Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

Cartilage destruction in rheumatoid arthritis (RA) occurs primarily in the pannus-cartilage interface. The close contact of the synovium-cartilage interface implicates crosstalk between synovial fibroblasts and chondrocytes. The aim of this study is to explore the differentially expressed genes and novel microRNA regulations potentially implicated in the dysregulated cartilage homeostasis in joint destruction of RA. Read More

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July 2018
1 Read

Evaluation of Recipients of Positive and Negative Secondary Findings Evaluations in a Hybrid CLIA-Research Sequencing Pilot.

Am J Hum Genet 2018 Sep 16;103(3):358-366. Epub 2018 Aug 16.

Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA. Electronic address:

While consensus regarding the return of secondary genomic findings in the clinical setting has been reached, debate about such findings in the research setting remains. We developed a hybrid, research-clinical translational genomics process for research exome data coupled with a CLIA-validated secondary findings analysis. Eleven intramural investigators from ten institutes at the National Institutes of Health piloted this process. Read More

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September 2018
5 Reads