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    [Cryoglobulins and cryoglobulinemic vasculitis].
    Wiad Lek 2018 ;71(1 pt 1):59-63
    Katedra i Klinika Reumatologii i Układowych Chorób Tkanki Łącznej, Uniwersytet Medyczny, Lublin, Polska.
    Cryoglobulinemia is defined as the presence of cryoglobulins in the blood. Cryoglobulinemia is often observed in the course of many diseases (infection, hematological disorders, autoimmune disorders) or has an idiopathic character. The classification of cryoglobulinemia is based on the immunological analysis of cryoglobulins and the activity of the rheumatoid factor (RF). Read More

    An Information-Motivation-Behavioral Skills Model of PrEP Uptake.
    AIDS Behav 2018 Mar 20. Epub 2018 Mar 20.
    Department of Medicine, Section of Rheumatology, Yale University School of Medicine, PO Box 208031, 300 Cedar Street, TAC Bldg., New Haven, CT, 06520-8031, USA.
    Despite documented effectiveness of pre-exposure prophylaxis (PrEP), PrEP uptake remains low among at-risk populations. The 2015 CDC report estimates that about 1.2 million people in the US have indications for PrEP. Read More

    Role of MDA-7/IL-24 a Multifunction Protein in Human Diseases.
    Adv Cancer Res 2018 2;138:143-182. Epub 2018 Mar 2.
    Virginia Commonwealth University, School of Medicine, Richmond, VA, United States; VCU Institute of Molecular Medicine, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States; VCU Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA, United States. Electronic address:
    Subtraction hybridization identified genes displaying differential expression as metastatic human melanoma cells terminally differentiated and lost tumorigenic properties by treatment with recombinant fibroblast interferon and mezerein. This approach permitted cloning of multiple genes displaying enhanced expression when melanoma cells terminally differentiated, called melanoma differentiation associated (mda) genes. One mda gene, mda-7, has risen to the top of the list based on its relevance to cancer and now inflammation and other pathological states, which based on presence of a secretory sequence, chromosomal location, and an IL-10 signature motif has been named interleukin-24 (MDA-7/IL-24). Read More

    Predictors of hypogammaglobulinemia during rituximab maintenance therapy in rheumatoid arthritis: A 12-year longitudinal multi-center study.
    Semin Arthritis Rheum 2018 Feb 21. Epub 2018 Feb 21.
    Université Paris Descartes, Sorbonne Paris Cité, Service de Rhumatologie A, Hôpital Cochin, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, INSERM U1016, Institut Cochin, CNRS UMR8104, Paris, France. Electronic address:
    Objective: Rituximab (RTX) is an anti-CD20 monoclonal antibody that selectively depletes B-cell population. Thus, it presents a potential risk for the development of hypogammaglobulinemia and related infectious events. Our aim was to identify predictors of hypogammaglobulinemia in RA patients long-term treated with RTX. Read More

    Macrophage Migration Inhibitory Factor -173 G/C Polymorphism: A Global Meta-Analysis across the Disease Spectrum.
    Front Genet 2018 1;9:55. Epub 2018 Mar 1.
    Unidad de Biomedicina, Facultad de Estudios Superiores-Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla de Baz, Mexico.
    Human macrophage migration inhibitory factor (MIF) is a cytokine that plays a role in several metabolic and inflammatory processes. Single nucleotide polymorphism (SNP) -173 G/C (rs755622) ongene has been associated with numerous diseases, such as arthritis and cancer. However, most of the reports concerning the association of MIF with these and other pathologies are inconsistent and remain quite controversial. Read More

    Influence of Inflammation in the Process of T Lymphocyte Differentiation: Proliferative, Metabolic, and Oxidative Changes.
    Front Immunol 2018 1;9:339. Epub 2018 Mar 1.
    Department of Immunology, Hospital Universitario Central de Asturias (HUCA), Oviedo, Spain.
    T lymphocytes, from their first encounter with their specific antigen as naïve cell until the last stages of their differentiation, in a replicative state of senescence, go through a series of phases. In several of these stages, T lymphocytes are subjected to exponential growth in successive encounters with the same antigen. This entire process occurs throughout the life of a human individual and, earlier, in patients with chronic infections/pathologies through inflammatory mediators, first acutely and later in a chronic form. Read More

    Cardiovascular Risk Markers and Major Adverse Cardiovascular Events in Psoriatic Arthritis Patients.
    Rev Recent Clin Trials 2018 Mar 13. Epub 2018 Mar 13.
    Department of Clinical Medicine and Surgery - Rheumatology Research Unit - Federico II University, Naples. Italy.
    Background: Psoriatic arthritis is a chronic inflammatory arthropathy that affects 14%-30% of patients with skin and/or nail psoriasis and leading to severe physical limitations and disability. It has been included in the group of spondyloarthropathy with which it shares clinical, radiologic, and serologic features in addition to familial and genetic relationship. Beyond skin and joint involvement, psoriatic arthritis is characterized by a high prevalence of extra-articular manifestation and comorbidities, such as autoimmune, infectious and neoplastic diseases. Read More

    Differential diagnosis of a fused wrist with a partially destroyed capitate from Kazakhstan (1st-3rd century AD).
    Int J Paleopathol 2016 Mar 30;12:46-52. Epub 2015 Dec 30.
    Department of Natural Sciences, German Archaeological Institute, Im Dol 2-6, 14195 Berlin, Germany.
    We discuss here the differential diagnosis of carpal ankylosis along with the second and third metacarpals of the right hand in an adult male skeleton buried in a kurgan from Mayemer, Kazakhstan (86-242 AD, 95.4% cal.). Read More

    Iliacus-piriformis abscess and septic arthritis from Theban Tomb (TT) 65.
    Int J Paleopathol 2015 Mar 22;8:57-63. Epub 2014 Nov 22.
    Department of Egyptology, Institute of Ancient Studies, Eötvös Loránd University, Múzeum krt. 4/B, Budapest 1088, Hungary. Electronic address:
    The incomplete skeletonized remains of Person 3/3a, from Shaft Tomb 3 of Theban Tomb (TT) 65, show mixed osteolytic and osteoblastic lesions in the left os coxa, sacrum, and distal right radius, with less pronounced osteoblastic, possibly related lesions elsewhere. Iliacus-piriformis abscess and septic arthritis are deemed primarily responsible while other considered etiological entities are less likely. Read More

    A Case Report of Chikungunya Fever, Rheumatoid Arthritis, and Felty's Syndrome.
    Rheumatol Ther 2018 Mar 13. Epub 2018 Mar 13.
    Section of Rheumatology, Yale University School of Medicine, New Haven, CT, USA.
    Introduction: Chronic chikungunya (CHIK) arthritis, an inflammatory arthritis, often follows acute CHIK fever (CHIKF), a viral infection. The pathogenesis of chronic CHIK arthritis is poorly characterized, but may resemble other forms of inflammatory arthritis. Clinically, chronic CHIK arthritis sometimes mimics rheumatoid arthritis (RA). Read More

    Modulation of inflammatory arthritis by gut microbiota through mucosal inflammation and autoantibody generation.
    Arthritis Rheumatol 2018 Mar 13. Epub 2018 Mar 13.
    Department of Medicine, Divisions of Rheumatology.
    Objective: Observations of microbial dysbiosis in patients with RA have raised interest in studying microbial-mucosal interactions as a potential trigger of RA. Using the murine collagen-induced arthritis (CIA) model, we hypothesized that microbiota modulate immune responses leading to autoimmune arthritis.

    Methods: CIA was induced by immunization of mice with type II collagen (CII) in adjuvant on days 0 and 21, with arthritis appearing at days 23-24. Read More

    Cause-specific mortality in a large population-based cohort of patients with rheumatoid arthritis in Italy.
    Clin Exp Rheumatol 2018 Mar 2. Epub 2018 Mar 2.
    Epidemiological Department, Veneto Region, Italy.
    Objectives: The aim of our study was to investigate cause-specific mortality in rheumatoid arthritis (RA) subjects living in Italy.

    Methods: We identified in the electronic archive of the Veneto Region patients aged 20-89 years who were exempt from co-payment for RA in January 2010, and linked them with the archive of causes of deaths of the period 2010-2015. Causes of death were coded according to the International Classification of Diseases, 10th Edition. Read More

    A Case of Disseminated Histoplasmosis in a Patient with Rheumatoid Arthritis on Abatacept.
    J Gen Intern Med 2018 Mar 12. Epub 2018 Mar 12.
    Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
    Biologic agents are effective treatments for rheumatoid arthritis but are associated with important risks, including severe infections. Tumor Necrosis Factor (TNF) α inhibitors are known to increase the risk of systemic fungal infections such as disseminated histoplasmosis. Abatacept is a biologic agent with a mechanism different from that of TNFα inhibitors: It suppresses cellular immunity by competing for the costimulatory signal on antigen-presenting cells. Read More

    Beekeeper' arthropathy.
    Reumatol Clin 2018 Mar 9. Epub 2018 Mar 9.
    Unidad de Reumatología, Clínica Ponferrada, Ponferrada, León, España.
    An acute inflammatory arthritis of unknown cause has been described in beekeepers in relation to their work with the hives. We present the case of a beekeeper who, after a bee sting, developed arthritis of the interphalangeal joint of the first finger of his left hand. Although the subacute clinical course and the magnetic resonance imaging findings required the differential diagnosis with an infectious process, the rest of the laboratory tests. Read More

    Psoriasis treatment in HIV-positive patients: a systematic review of systemic immunosuppressive therapies.
    Cutis 2018 Jan;101(1):38;42;56
    Psoriasis and Skin Treatment Center, Department of Dermatology, University of California, San Francisco, USA.
    The management of psoriatic disease in the human immunodeficiency virus (HIV)-positive population is challenging. The clinical course often is progressive and refractory; therefore, first- and second-line therapies including topical agents, phototherapy, and oral retinoids often are inadequate. Most other currently available systemic therapies for psoriatic disease are immunosuppressive, which poses a distinct clinical challenge. Read More

    The conundrum of indeterminate QuantiFERON-TB Gold results before anti-tumor necrosis factor initiation.
    Biologics 2018 27;12:61-67. Epub 2018 Feb 27.
    Department of Medicine.
    Background: Tumor necrosis factor alpha (TNFα) is a key cytokine in both the pathogenesis of inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) and the host defense against tuberculosis (TB). Consequently, anti-TNFα medications result in an increased risk of latent TB infection (LTBI) reactivation. Here, we sought to evaluate the factors affecting the results of QuantiFERON-TB Gold In-Tube (QFT-GIT) assay as a screening tool for LTBI. Read More

    Evaluation of a clinical pharmacogenetics model to predict methotrexate response in patients with rheumatoid arthritis.
    Pharmacogenomics J 2018 Mar 8. Epub 2018 Mar 8.
    Experimental and Observational Rheumatology and Rheumatology Unit. Instituto de Investigación Sanitaria, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain.
    Variability of response to treatment hinders successful management of rheumatoid arthritis (RA). Consequently, a clinical pharmacogenetics model for predicting response to methotrexate (CP-MTX) has been previously proposed that includes four clinical variables (disease activity, sex, the presence of rheumatoid factor and smoking status) and four SNPs (rs2236225, rs17602729, rs1127354, and rs2372536) in genes of the folate pathway. It showed good performance, but failed to attract attention, likely, in relation with lack of clear clinical benefit. Read More

    Cavitary Lung Diseases-A Clinical-Radiological Algorithmic Approach.
    Chest 2018 Mar 5. Epub 2018 Mar 5.
    Cavities are occasionally encountered on thoracic imaging. Their differential diagnosis is large and includes, among others, various infections, autoimmune conditions and primary and metastatic malignancies. We offer an algorithmic approach to their evaluation by initially excluding mimics of cavities then broadly classifying them according to the duration of clinical symptoms and radiological abnormalities. Read More

    The Potential Role of Trained Immunity in Autoimmune and Autoinflammatory Disorders.
    Front Immunol 2018 20;9:298. Epub 2018 Feb 20.
    Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, Netherlands.
    During induction of trained immunity, monocytes and macrophages undergo a functional and transcriptional reprogramming toward increased activation. Important rewiring of cellular metabolism of the myeloid cells takes place during induction of trained immunity, including a shift toward glycolysis induced through the mTOR pathway, as well as glutaminolysis and cholesterol synthesis. Subsequently, this leads to modulation of the function of epigenetic enzymes, resulting in important changes in chromatin architecture that enables increased gene transcription. Read More

    An amino acid motif in HLA-DRβ1 distinguishes patients with uveitis in juvenile idiopathic arthritis.
    Arthritis Rheumatol 2018 Mar 7. Epub 2018 Mar 7.
    Department of Ophthalmology, University Medical Center Utrecht, Utrecht University, The Netherlands.
    Objectives: Uveitis is a visually-debilitating disorder that affects up to 30% of children with the most common forms of juvenile idiopathic arthritis (JIA). The disease mechanisms predisposing only a subgroup of children to uveitis are unknown. To identify genetic susceptibility loci for uveitis in JIA, we conducted a genome-wide association study totalling 522 JIA cases. Read More

    [Viral arthritis].
    Rev Med Suisse 2018 Mar;14(597):526-528
    Service de rhumatologie, Département de l'appareil locomoteur, CHUV, 1011 Lausanne.
    Arthritis and arthralgia during a viral infection are often polyarticular and symmetric and can mimic rheumatoid arthritis. Depending on germs, others signs and symptoms as fever, cutaneous rash (Parvovirus B19) or jaundice (hepatitis) can be present. Worldwide most common germs are Parvovirus B19, hepatitis B and C, HIV and alphavirus. Read More

    [Septic arthritis diagnosis : the role of microbiology].
    Rev Med Suisse 2018 Mar;14(597):509-515
    Service des maladies infectieuses, HUG, 1211 Genève 14.
    Septic arthritis is a medical and surgical emergency. It is therefore essential to promptly differentiate an infectious from a non-infectious origin in order to improve the prognostic (mortality and morbidity). To do so the clinician needs not only to know which tests are available but also how to adequately use them and interpret their results. Read More

    Th1-Th17 Ratio as a New Insight in Rheumatoid Arthritis Disease.
    Iran J Allergy Asthma Immunol 2018 Feb;17(1):68-77
    Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
    The Th17, Th1 and dual Th17/Th1 cells are important players in rheumatoid arthritis (RA) disease. To assess their roles, the frequency and impact of these cells were investigated in patients with different disease activity. In 14 new cases and 41 established RA patients in comparison with 22 healthy controls, the percentages of Th17, Th1 and dual Th17/Th1 cells were determined by flow-cytometry and their correlations were investigated with disease activity score (DAS28). Read More

    Fatal visceral disseminated varicella zoster infection during initial remission induction therapy in a patient with lupus nephritis and rheumatoid arthritis-possible association with mycophenolate mofetil and high-dose glucocorticoid therapy: a case report.
    BMC Res Notes 2018 Mar 5;11(1):165. Epub 2018 Mar 5.
    Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata City, Niigata, 951-8510, Japan.
    Background: Visceral disseminated varicella zoster viral (VZV) infection is a rare but severe complication with a high mortality rate in immunosuppressed individuals, and an increased susceptibility to VZV has been reported in kidney transplant recipients who are treated with mycophenolate mofetil (MMF). In Japan, MMF is currently approved for patients with lupus nephritis (LN) and data to indicate its optimal dosage are still insufficient.

    Case Presentation: A 46-year-old Japanese woman with rheumatoid arthritis was diagnosed as having systemic lupus erythematosus (SLE) and LN class III (A/C). Read More

    Activation of Stimulator of Interferon Genes (STING) and Sjögren Syndrome.
    J Dent Res 2018 Mar 1:22034518760855. Epub 2018 Mar 1.
    1 Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
    Sjögren syndrome (SS), a chronic autoimmune disorder causing dry mouth, adversely affects the overall oral health in patients. Activation of innate immune responses and excessive production of type I interferons (IFNs) play a critical role in the pathogenesis of this disorder. Recognition of nucleic acids by cytosolic nucleic acid sensors is a major trigger for the induction of type I IFNs. Read More

    RORα-expressing T regulatory cells restrain allergic skin inflammation.
    Sci Immunol 2018 Mar;3(21)
    Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
    Atopic dermatitis is an allergic inflammatory skin disease characterized by the production of the type 2 cytokines in the skin by type 2 innate lymphoid cells (ILC2s) and T helper 2 (T2) cells, and tissue eosinophilia. Using two distinct mouse models of atopic dermatitis, we show that expression of retinoid-related orphan receptor α (RORα) in skin-resident T regulatory cells (T) is important for restraining allergic skin inflammation. In both models, targeted deletion of RORα in mouse Tled to exaggerated eosinophilia driven by interleukin-5 (IL-5) production by ILC2s and T2 cells. Read More

    A CD8αSubset of CD4SLAMF7Cytotoxic T Cells is Expanded in Patients with IgG4-Related Disease and Decreases following Glucocorticoid Treatment.
    Arthritis Rheumatol 2018 Mar 2. Epub 2018 Mar 2.
    Università Vita-Salute San Raffaele, Unit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS San Raffaele Scientific Institute, Milan, Italy.
    Objective: An unconventional population of CD4SLAMF7cytotoxic Tcells (CD4CTLs) has been linked causally to IgG4-related disease (IgG4-RD). Glucocorticoids represent the first line therapeutic approach in patients with IgG4-RD but their mechanism of action in this specific condition remains unknown. Here we describe the impact of glucocorticoids on CD4CTLs in IgG4-RD. Read More

    Control of hyperglycemia in male mice by leflunomide: mechanisms of action.
    J Endocrinol 2018 Apr;237(1):43-58
    Institute of Comparative MedicineYangzhou University, Yangzhou, Jiangsu Province, China
    p70 S6 kinase (S6K1) is a serine/threonine kinase that phosphorylates the insulin receptor substrate-1 (IRS-1) at serine 1101 and desensitizes insulin receptor signaling. S6K1 hyperactivation due to overnutrition leads to hyperglycemia and type 2 diabetes. Our recent study showed that A77 1726, the active metabolite of the anti-rheumatoid arthritis (RA) drug leflunomide, is an inhibitor of S6K1. Read More

    [Scleritis and systemic diseases: What should know the internist?]
    Rev Med Interne 2018 Feb 26. Epub 2018 Feb 26.
    Service de médecine interne, hospices civils de Lyon, hôpital de la Croix-Rousse, 103, grande rue de la Croix-Rousse, 69317 Lyon cedex 04, France; Université de Lyon, 69100 Lyon, France. Electronic address:
    Scleritis is an inflammatory disease of the sclera; outer tunic of the eye on which the oculomotor muscles are inserted. It can be associated with a systemic disease up to one time out of 3. These associated diseases are mainly rheumatoid arthritis, vasculitis, including granulomatosis with polyangiitis in the first line and spondyloarthropathies. Read More

    Adult T-cell Leukemia/Lymphoma as a Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis - A Case Report.
    Intern Med 2018 Feb 28. Epub 2018 Feb 28.
    Department of Rheumatology, Infectious Diseases and Laboratory Medicine, Internal Medicine, Faculty of Medicine, University of Miyazaki, Japan.
    The patient was a 74-year-old Japanese woman with rheumatoid arthritis (RA) who developed generalized lymphadenopathy with elevated levels of lactase dehydrogenase (LD), and soluble IL-2 receptor (sIL-2R). She was found to be positive for anti-human T-cell leukemia virus type 1 (HTLV-1) antibodies. Her symptoms and laboratory abnormalities spontaneously regressed after the cessation of methotrexate (MTX), suggesting that she had an MTX-associated lymphoproliferative disorder; however, her lymphadenopathy appeared again approximately 14 months later with LD and sIL-2R elevation. Read More

    STAT-3-independent production of IL-17 by mouse innate-like αβ T cells controls ocular infection.
    J Exp Med 2018 Feb 28. Epub 2018 Feb 28.
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD
    Appropriate regulation of IL-17 production in the host can mean the difference between effective control of pathogens and uncontrolled inflammation that causes tissue damage. Investigation of conventional CD4T cells (Th17 cells) has yielded invaluable insights into IL-17 function and its regulation. More recently, we and others reported production of IL-17 from innate αβ+ T cell populations, which was shown to occur primarily via IL-23R signaling through the transcription factor STAT-3. Read More

    Improving saliva shotgun metagenomics by chemical host DNA depletion.
    Microbiome 2018 Feb 27;6(1):42. Epub 2018 Feb 27.
    Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.
    Background: Shotgun sequencing of microbial communities provides in-depth knowledge of the microbiome by cataloging bacterial, fungal, and viral gene content within a sample, providing an advantage over amplicon sequencing approaches that assess taxonomy but not function and are taxonomically limited. However, mammalian DNA can dominate host-derived samples, obscuring changes in microbial populations because few DNA sequence reads are from the microbial component. We developed and optimized a novel method for enriching microbial DNA from human oral samples and compared its efficiency and potential taxonomic bias with commercially available kits. Read More

    Genetic polymorphism of rs9277535 in HLA-DP associated with rheumatoid arthritis and anti-CCP production in a Chinese population.
    Clin Rheumatol 2018 Feb 23. Epub 2018 Feb 23.
    Department of lab medicine, West China Hospital, Sichuan University, Sichuan Province, Chengdu, China.
    HLA-II molecules are critical in triggering human immune response, especially in activating CD4+ T cells. HLA-DP, belonging to HLA-II molecules, draws increasing attention for its role in presentation of viral antigen and autoantigen to T cells. Researches reported single nucleotide polymorphism (SNP) of HLA-DP associated with HBV infection and autoimmune diseases such as SLE. Read More

    Attenuated effectiveness of tumor necrosis factor inhibitors for anti-human T-lymphotropic virus type 1 antibody-positive rheumatoid arthritis.
    Arthritis Rheumatol 2018 Feb 22. Epub 2018 Feb 22.
    Department of Immunology and Rheumatology.
    Objectives: We evaluated the effectiveness of tumor necrosis factor (TNF) inhibitors for the treatment of human T-lymphotropic virus type 1 (HTLV-I)-positive rheumatoid arthritis (RA) patients in an HTLV-I endemic area.

    Methods: We conducted an observational study of 585 RA patients for whom TNF inhibitors were newly introduced as a first biologic disease-modifying antirheumatic drug (bDMARD) in an HTLV-I endemic area in southwestern Japan.

    Results: Fifty patients (8. Read More

    Smoking and female sex as key risk factors associated with severe arthralgia in acute and chronic phases of Chikungunya virus infection.
    Exp Ther Med 2018 Mar 21;15(3):2634-2642. Epub 2017 Dec 21.
    Cancerology State Institute, Colima State Health Services, Colima 28085, Mexico.
    Arthralgia is a potentially incapacitating condition and a persistent symptom in chronic or acute episodes of Chikungunya fever caused by infection with the Chikungunya virus (CHIKV). To the best of our knowledge, there are no reports on risk factors associated with the intensity of arthralgias in typical acute episodes of the disease. Although a number of studies have reported on risk factors associated with the development of the chronic stage of the disease, smoking habits have not been analyzed. Read More

    Management of Recurrent Vestibular Neuritis in a Patient Treated for Rheumatoid Arthritis.
    Am J Audiol 2018 Mar;27(1):19-24
    Department of Hearing and Speech Sciences, Vanderbilt Bill Wilkerson Center, Nashville, TN.
    Purpose: This clinical report is presented to describe how results of vestibular function testing were considered along with other medical history to develop a management plan that was ultimately successful.

    Method: The patient underwent audio-vestibular assessment including comprehensive audiogram, videonystagmography, cervical vestibular evoked myogenic potential, and postural stability testing.

    Results: Results from initial testing were most consistent with uncompensated peripheral vestibular dysfunction affecting the right superior vestibular nerve. Read More

    Chondrocytes Contribute to Alphaviral Disease Pathogenesis as a Source of Virus Replication and Soluble Factor Production.
    Viruses 2018 Feb 15;10(2). Epub 2018 Feb 15.
    Institute for Glycomics, Griffith University, Gold Coast Campus, Southport, QLD 4215, Australia.
    Arthritogenic alphavirus infections often result in debilitating musculoskeletal disorders that affect the joints, muscle, and bone. In order to evaluate the infection profile of primary human skeletal muscle and chondrocyte cells to Ross River virus (RRV) in vitro, cells were infected at a multiplicity of infection (MOI) of 1 over a period of two days. Viral titers were determined by plaque assay and cytokine expression by Bio-Plexassays using the supernatants harvested. Read More

    Targeting Intramembrane Protein-Protein Interactions: Novel Therapeutic Strategy of Millions Years Old.
    Adv Protein Chem Struct Biol 2018 24;111:61-99. Epub 2017 Jul 24.
    SignaBlok, Inc., Shrewsbury, MA, USA. Electronic address:
    Intramembrane protein-protein interactions (PPIs) are involved in transmembrane signal transduction mediated by cell surface receptors and play an important role in health and disease. Recently, receptor-specific modulatory peptides rationally designed using a general platform of transmembrane signaling, the signaling chain homooligomerization (SCHOOL) model, have been proposed to therapeutically target these interactions in a variety of serious diseases with unmet needs including cancer, sepsis, arthritis, retinopathy, and thrombosis. These peptide drug candidates use ligand-independent mechanisms of action (SCHOOL mechanisms) and demonstrate potent efficacy in vitro and in vivo. Read More

    Host defense against oral microbiota by bone-damaging T cells.
    Nat Commun 2018 Feb 16;9(1):701. Epub 2018 Feb 16.
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, 113-0033, Tokyo, Japan.
    The immune system evolved to efficiently eradicate invading bacteria and terminate inflammation through balancing inflammatory and regulatory T-cell responses. In autoimmune arthritis, pathogenic T17 cells induce bone destruction and autoimmune inflammation. However, whether a beneficial function of T-cell-induced bone damage exists is unclear. Read More

    Neutrophils drive type I interferon production and autoantibodies in patients with Wiskott-Aldrich syndrome.
    J Allergy Clin Immunol 2018 Feb 13. Epub 2018 Feb 13.
    International Centre for Genetic Engineering and Biotechnology, Trieste, Italy. Electronic address:
    Background: Wiskott-Aldrich syndrome (WAS) is a rare primary immunodeficiency caused by mutations in Wiskott-Aldrich syndrome protein (WASp), a key regulator of cytoskeletal dynamics in hematopoietic cells. A high proportion of patients experience autoimmunity caused by a breakdown in T- and B-cell tolerance. Moreover, excessive production of type I interferon (IFN-I) by plasmacytoid dendritic cells (pDCs) contributes to autoimmune signs; however, the factors that trigger excessive innate activation have not been defined. Read More

    Guidelines for management of rheumatic diseases in developing countries from basics to real-world situation: relevance, need, and processes for development.
    Rheumatol Int 2018 Apr 14;38(4):549-556. Epub 2018 Feb 14.
    Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, 226014, India.
    Guidelines or recommendations help to provide uniform standards in medical practice. The development of guidelines requires adherence to pre-defined norms prescribed by different international organizations such as the European League against Rheumatism (EULAR). We searched Pubmed and LILACS to identify published papers in five major rheumatic diseases (rheumatoid arthritis, systemic lupus erythematosus, spondyloarthropathies, osteoarthritis, and scleroderma) from different countries based on their economic prosperity and could find a lack of published literature from most economically weaker regions. Read More

    Native-Joint Septic Arthritis: Case Report and Review of the Literature.
    Case Rep Infect Dis 2017 28;2017:8903907. Epub 2017 Dec 28.
    University of Illinois at Chicago, Division of Infectious Diseases, Department of Medicine, Chicago, IL, USA.
    is a skin commensal classified as a coagulase-negative(CoNS). Though CoNS is typically associated with less aggressive clinical disease than, there is growing awareness thatmay be as virulent as. The association betweenand infective endocarditis is well known, but few reports of native-joint disease with this organism exist. Read More

    Suture-induced arthritis as a clinical mimicker of septic arthritis.
    Clin Case Rep 2018 Feb 11;6(2):249-252. Epub 2017 Dec 11.
    2-4-2 Kajimachi #201KokurakitaKitakyushuFukuoka802-0004Japan.
    Foreign body-induced arthritis is a rare etiology of mono-arthritis. It should be suspected in the case of postoperative arthritis, even if some decades have passed since surgery. Histopathology of the tissues is required for a definitive diagnosis, and debridement is essential for complete recovery. Read More

    Sex bias in MHC I-associated shaping of the adaptive immune system.
    Proc Natl Acad Sci U S A 2018 Feb 12;115(9):2168-2173. Epub 2018 Feb 12.
    Department of Neurology, University of Muenster, 48149 Muenster, Germany;
    HLA associations, T cell receptor (TCR) repertoire bias, and sex bias have independently been shown for many diseases. While some immunological differences between the sexes have been described, they do not fully explain bias in men toward many infections/cancers, and toward women in autoimmunity. Next-generation TCR variable beta chain (TCRBV) immunosequencing of 824 individuals was evaluated in a multiparametric analysis including HLA-A -B/MHC class I background, TCRBV usage, sex, age, ethnicity, and TCRBV selection/expansion dynamics. Read More

    Impact of red and processed meat and fibre intake on treatment outcomes among patients with chronic inflammatory diseases: protocol for a prospective cohort study of prognostic factors and personalised medicine.
    BMJ Open 2018 02 8;8(2):e018166. Epub 2018 Feb 8.
    Focused Research Unit for Molecular Diagnostic and Clinical Research, IRS-Center Sonderjylland, Hospital of Southern Jutland, Aabenraa, Denmark.
    Introduction: Chronic inflammatory diseases (CIDs) are frequently treated with biological medications, specifically tumour necrosis factor inhibitors (TNFi)). These medications inhibit the pro-inflammatory molecule TNF alpha, which has been strongly implicated in the aetiology of these diseases. Up to one-third of patients do not, however, respond to biologics, and lifestyle factors are assumed to affect treatment outcomes. Read More

    Chikungunya: A rheumatologist's perspective.
    Int J Rheum Dis 2018 Mar 12;21(3):584-601. Epub 2018 Feb 12.
    Unit of Clinical Immunology and Rheumatology, Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    Chikungunya (CHIK), a viral infection, is transmitted by Aedes mosquitoes. It is characterized by a phase of acute infection, which is sometimes followed by chronic rheumatisim in the form of arthralgia or myalgia that can last for months and even years. Several studies have been conducted to understand the mechanisms underlying inflammation associated with CHIK infection, persistence of viruses in monocytes-macrophages, and their relationship to the chronic symptoms. Read More

    Analysis of mortality in a cohort of 650 cases of bacteremic osteoarticular infections.
    Semin Arthritis Rheum 2018 Jan 31. Epub 2018 Jan 31.
    Department of Infectious Diseases, Hospital Universitari de Bellvitge, IDIBELL, Universidad de Barcelona, Feixa Llarga s/n, 08907 L'Hospitalet de Llobregat, Barcelona, Spain.
    Objectives: The mortality of patients with bacteremic osteoarticular infections (B-OAIs) is poorly understood. Whether certain types of OAIs carry higher mortality or interventions like surgical debridement can improve prognosis, are unclarified questions.

    Methods: Retrospective analysis of a prospective cohort of patients with B-OAIs treated at a teaching hospital in Barcelona (1985-2014), analyzing mortality (30-day case-fatality rate). Read More

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