2,456 results match your criteria Villous Adenoma


Nomograms that predict the survival of patients with adenocarcinoma in villous adenoma of the colorectum: a SEER-based study.

BMC Cancer 2020 Jun 29;20(1):608. Epub 2020 Jun 29.

Department of Gastroenterology, the First Affiliated Hospital of Nanchang University, 17 Yongwaizheng Street, Nanchang, 330006, Jiangxi, China.

Background: Considering that the knowledge of adenocarcinoma in villous adenoma of the colorectum is limited to several case reports, we designed a study to investigate independent prognostic factors and developed nomograms for predicting the survival of patients.

Methods: Univariate and multivariate Cox regression analyses were used to evaluate prognostic factors. A nomogram predicting cancer-specific survival (CSS) was performed; internally and externally validated; evaluated by receiver operating characteristic (ROC) curve, C-index, and decision curve analyses; and compared to the 7th TNM stage. Read More

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http://dx.doi.org/10.1186/s12885-020-07099-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325241PMC

Post-polypectomy colonoscopy surveillance: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2020.

Endoscopy 2020 Jun 22. Epub 2020 Jun 22.

Gastroenterology Department, Hospital Universitario de Canarias, Instituto Universitario de Tecnologías Biomédicas (ITB) & Centro de Investigación Biomédica de Canarias (CIBICAN), Universidad de La Laguna, Tenerife, Spain.

The following recommendations for post-polypectomy colonoscopic surveillance apply to all patients who had one or more polyps that were completely removed during a high quality baseline colonoscopy. 1: ESGE recommends that patients with complete removal of 1 - 4 < 10 mm adenomas with low grade dysplasia, irrespective of villous components, or any serrated polyp < 10 mm without dysplasia, do not require endoscopic surveillance and should be returned to screening.Strong recommendation, moderate quality evidence. Read More

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http://dx.doi.org/10.1055/a-1185-3109DOI Listing

Molecular Genetic Features of Primary Nonurachal Enteric-type Adenocarcinoma, Urachal Adenocarcinoma, Mucinous Adenocarcinoma, and Intestinal Metaplasia/Adenoma: Review of the Literature and Next-generation Sequencing Study.

Adv Anat Pathol 2020 Jun 5. Epub 2020 Jun 5.

Departments of Pathology.

The diagnosis of primary adenocarcinoma of the urinary bladder may be challenging in routine practice. These tumors may morphologically and immunohistochemically overlap with urachal adenocarcinoma and colorectal adenocarcinoma. Further, their genetic background is poorly understood. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000268DOI Listing
June 2020
3.229 Impact Factor

Colonoscopy in patients with psoriasis before the initiation of treatment with biological agents.

Dermatol Ther 2020 Jun 7:e13720. Epub 2020 Jun 7.

Intensive Care Unit, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey.

Psoriasis may lead to subsequent colorectal cancer, since chronic systemic inflammation is the common etiologic factor in both psoriasis and colorectal cancer. It is a matter of dispute whether biological agents used in the treatment of psoriasis cause predisposition to colorectal cancer as a result of their immunosuppressive effect. Medical records of psoriasis patients who underwent colonoscopy before biological agents were reviewed. Read More

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http://dx.doi.org/10.1111/dth.13720DOI Listing

Villous adenoma of the urachus obscuring urachal adenocarcinoma: A case report.

Urol Case Rep 2020 Sep 20;32:101271. Epub 2020 May 20.

Department of Urology, Tottori Prefectural Central Hospital, 730 Ezu, Tottori, 680-0901, Japan.

We report a case of a 78-year-old woman with a urachal tumor of the bladder wall. We performed a biopsy and revealed the tumor as a villous adenoma. We excised the tumor by partial cystectomy together with the umbilical ligament, because it was possible there was a co-existing malignancy. Read More

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http://dx.doi.org/10.1016/j.eucr.2020.101271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251388PMC
September 2020

≥3 Nonadvanced Adenomas are More Common in the Era of Contemporary Colonoscopy and Not Associated With Metachronous Advanced Neoplasia.

J Clin Gastroenterol 2020 May 15. Epub 2020 May 15.

Departments of Gastroenterology, Hepatology and Nutrition.

Introduction: Data from standard definition colonoscopy era demonstrate patients with an advanced adenoma (≥10 mm, villous features or high-grade dysplasia) or ≥3 nonadvanced adenomas are considered high-risk for metachronous advanced neoplasia (MAN). Low-risk adenoma (LRA) patients are those with 1 to 2, <10 mm tubular adenomas. High definition colonoscopy, split-dose bowel preparation, and attention to adenoma detection enhance diminutive adenoma detection. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001364DOI Listing

Lessons of the month 2: McKittrick-Wheelock syndrome: Case report of a patient declining resection of a large villous adenoma.

Clin Med (Lond) 2020 May;20(3):295-297

Colchester General Hospital, Colchester, UK.

McKittrick-Wheelock syndrome (MWS) is a rare cause of acute kidney injury and electrolyte depletion. It is driven by a secretory tumour or polyp of the distal large colon. Although rare, it is a diagnosis that must be considered in patients presenting with the above conditions. Read More

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http://dx.doi.org/10.7861/clinmed.2019-0356DOI Listing

Endocytoscopic Observation of Non-Ampullary Mucosal Duodenal Cancer.

Case Rep Gastroenterol 2020 Jan-Apr;14(1):156-164. Epub 2020 Apr 14.

Department of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Saitama, Japan.

Our previous study of duodenal adenoma using an endocytoscopy system (ECS) demonstrated that disappearance of goblet cells and spindle-shaped nuclei with loss of polarity were characteristic features. In addition, round duct openings and finger-like projections were observed in tubular adenoma and villous adenoma, respectively. Here, we retrospectively investigated six cases of histologically proven sporadic non-ampullary mucosal duodenal cancer (NAMDC) using ECS. Read More

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http://dx.doi.org/10.1159/000506930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184857PMC

Association of second surveillance colonoscopy findings with index and first surveillance colonoscopy results.

J Dig Dis 2020 May;21(5):272-278

Department of Gastroenterology, Tonan Hospital, Sapporo, Hokkaido, Japan.

Objective: Although there have been established guidelines for first surveillance colonoscopy (FSC) after a polypectomy, there is no consensus on performing a second surveillance colonoscopy (SSC), especially in Asian countries. This study aimed to investigate the association of SSC findings with index total colonoscopy (TCS) and FSC results.

Methods: This was a single-center retrospective cohort study involving 1928 consecutive Japanese patients who had received three or more colonoscopies. Read More

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http://dx.doi.org/10.1111/1751-2980.12869DOI Listing

Evaluation of a Deep Neural Network for Automated Classification of Colorectal Polyps on Histopathologic Slides.

JAMA Netw Open 2020 Apr 1;3(4):e203398. Epub 2020 Apr 1.

Department of Biomedical Data Science, Dartmouth College, Hanover, New Hampshire.

Importance: Histologic classification of colorectal polyps plays a critical role in screening for colorectal cancer and care of affected patients. An accurate and automated algorithm for the classification of colorectal polyps on digitized histopathologic slides could benefit practitioners and patients.

Objective: To evaluate the performance and generalizability of a deep neural network for colorectal polyp classification on histopathologic slide images using a multi-institutional data set. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.3398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180424PMC

A rare case of huge villous adenoma of the renal pelvis deforming the abdominal wall.

Urol Case Rep 2020 Jul 6;31:101183. Epub 2020 Apr 6.

Department of Pathoanatomy, Medical University Pleven, Bulgaria.

The villous adenoma is a benign epithelial tumor affecting most often the gastrointestinal tract, especially the colon and rectum. The incidence of this disease in the genitourinary tract is less than 1% as the most commonly affected organs are bladder, urethra, prostate, vulva and vagina. Only several cases of villous adenoma in the renal pelvis have been reported in the scientific literature. Read More

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http://dx.doi.org/10.1016/j.eucr.2020.101183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154995PMC

[A new one in the classification of benign colon epithelial tumors (WHO, 2019, 5th edition)].

Arkh Patol 2020 ;82(2):35-42

Lomonosov Moscow State University, Medical Research and Educational Center, 119192, Russian Federation, Moscow, Lomonosovsky Prospekt, 27-10.

The 2019 WHO Classification of Benign Colon Epithelial Neoplasms includes serrated dysplasia, adenomatous polyps, and glandular intraepithelial neoplasia. Serrated dysplasia (ICD-O 8213/0 and 8213/2) is former serrated masses. There is an expected change in its terminology: it is proposed to use the term 'sessile serrated lesion' (SSL) instead of that 'sessile serrated polyp/adenoma' that causes a lot of discussion. Read More

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http://dx.doi.org/10.17116/patol20208202135DOI Listing

Risk factors of advanced metachronous neoplasms in surveillance after colon cancer resection.

Korean J Intern Med 2020 Apr 21. Epub 2020 Apr 21.

Division of Gastroenterology, Department of Internal Medicine, Dankook University Hospital, Cheonan, Korea.

Background/aims: Regular surveillance colonoscopy after colon cancer resection is recommended for detecting metachronous adenoma and cancer. However, risk factors for metachronous neoplasms have not been fully evaluated. We aimed to assess risk factors for advanced metachronous neoplasms during surveillance colonoscopy after colon cancer resection. Read More

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http://dx.doi.org/10.3904/kjim.2019.053DOI Listing

Patients with non-colorectal cancers may be at elevated risk of colorectal neoplasia.

J Cancer 2020 4;11(11):3192-3198. Epub 2020 Mar 4.

Department of Gastroenterology, Hepatology, and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

: Screening for colonic neoplasia has decreased the incidence of colorectal cancer in the United States in the past two decades. Whether personal history of noncolorectal cancer is a risk factor for colonic neoplasia has not been well studied. We assessed the risk of colorectal neoplasia in noncolorectal cancer survivors. Read More

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http://dx.doi.org/10.7150/jca.40724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097953PMC
March 2020
2.639 Impact Factor

Poor Knowledge of Personal and Familial Colorectal Cancer Risk and Screening Recommendations Associated with Advanced Colorectal Polyps.

Dig Dis Sci 2020 Mar 6. Epub 2020 Mar 6.

University of Colorado Anschutz Medical Center, 12631 E 17th Avenue, Room 7614, Campus Box 158, Aurora, CO, 80045, USA.

Background And Aims: Advanced colorectal polyps (adenoma or sessile serrated polyp ≥ 1 cm, adenoma with villous features, adenoma with high-grade dysplasia, or any sessile serrated polyps with dysplasia) are associated with an increased risk of future advanced colorectal neoplasia and confer an increased risk of advanced neoplasia to first-degree family members. Professional societies therefore recommend more intensive surveillance of these polyps and earlier screening for first-degree relatives. The aim of this study was to assess knowledge of personal and familial risk and recommendations among patients with advanced colorectal polyps and identify predictors of knowledge. Read More

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http://dx.doi.org/10.1007/s10620-020-06167-9DOI Listing

Reliability in villous tumors staging between preoperative MRI and histopathological examination.

Abdom Radiol (NY) 2020 Mar 2. Epub 2020 Mar 2.

Brabois Imaging Department, Nancy University Hospital, Université de Lorraine, Nancy 1, Allée du Morvan, 54 511, Vandœuvre-lès-Nancy, France.

Purpose: This study aimed to assess the reliability of rectal villous tumors staging between rectal MRI and histological examination used as the Gold Standard and to investigate causes for discrepancies.

Methods: The rectal 1.5 T MR scans of 40 patients followed for a histologically proven rectal villous adenoma were retrospectively included. Read More

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http://dx.doi.org/10.1007/s00261-020-02450-5DOI Listing

Patterns of polyp histology: predictors of peril in the mucosa.

ANZ J Surg 2020 05 12;90(5):807-811. Epub 2020 Feb 12.

Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio, USA.

Background: Precursor colonic polyps of varied subtypes correlate with the known neoplastic pathways. When patients present with synchronous pre-malignant polyps of multiple histologies, multiple genetic mechanisms are likely to be active, potentially resulting in a more unstable, tumourigenic mucosa.

Methods: We hypothesized that patients with a combination of sessile serrated adenomas/polyps (SSA/Ps), hyperplastic (HP) polyps and adenomas would be at highest risk of developing dysplasia/cancer compared to SSA/Ps alone, due to the synergistic effect of multiple active carcinogenic pathways. Read More

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http://dx.doi.org/10.1111/ans.15662DOI Listing

A histopathological rarity: Primary signet ring cell carcinoma arising within a colonic villous adenoma.

Indian J Pathol Microbiol 2020 Jan-Mar;63(1):136-137

Department of Medical Gastroenterology, Bahrain Specialist Hospital, Juffair, Manama, Bahrain.

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http://dx.doi.org/10.4103/IJPM.IJPM_811_18DOI Listing
February 2020

The location of premalignant colorectal polyps under age 50: a further rationale for screening sigmoidoscopy.

Int J Colorectal Dis 2020 Mar 13;35(3):529-535. Epub 2020 Jan 13.

Department of Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA.

Purpose: The incidence of colorectal cancer (CRC) among young adults has been dramatically rising, with guidelines for screening recently adjusted to start at age 45. However, knowledge of the precursor lesions is limited. We recently reported that 83% of CRC diagnosed under age 50 are left sided. Read More

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http://dx.doi.org/10.1007/s00384-020-03504-2DOI Listing

Findings on Colonoscopy after Diverticulitis: A Multicenter Review.

Am Surg 2019 Dec;85(12):1381-1385

§Division of Colon and Rectal Surgery, Cook County Health and Hospitals System, Chicago, Illinois.

Diverticular disease is a common problem where patients with diverticulosis have a 1-4 per cent risk of acute diverticulitis. Current guidelines recommend a colonoscopy after.the resolution of acute diverticulitis. Read More

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December 2019

Water Exchange (WE) and Quality Improvement-Enhanced Advanced Adenoma Detection: A Pooled Data Analysis of 6 Randomized Controlled Trials.

J Clin Gastroenterol 2020 Mar;54(3):212-217

Division of Digestive Endoscopy and Gastroenterology, Valduce Hospital, Como, Italy.

Introduction: Advanced adenomas (≥10 mm in diameter, >25% villous, or high-grade dysplasia), a marker of colorectal cancer risk, are used to stratify patients for closer surveillance. Modern accessories, endoscopes, and age-adjusted evaluation have variable impacts on the advanced adenoma detection rate (AADR). In 1 randomized controlled trial (RCT) comparing air insufflation (AI) with water exchange (WE), the right colon AADR was significantly increased by WE. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001311DOI Listing

Intussusception in the Setting of Tuberous Sclerosis Complex.

ACG Case Rep J 2019 Oct 17;6(10):e00244. Epub 2019 Oct 17.

Division of Gastroenterology, Department of Medicine, Olive View-UCLA Medical Center, Sylmar, CA.

A 53-year-old man with tuberous sclerosis complex presented with severe, acute, right lower quadrant pain. The patient was found to have ileocolonic intussusception and a cecal mass on imaging. Diagnostic colonoscopy revealed a 3-cm cecal lesion which was grossly equivocal for hamartoma, adenoma, or other neoplasm, biopsies of which revealed villous adenoma. Read More

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http://dx.doi.org/10.14309/crj.0000000000000244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855532PMC
October 2019

Transanal endoscopic microsurgery for rectal villous tumours: Can we rely solely on preoperative biopsies and the surgeon’s experience?

Can J Surg 2019 12;62(6):454-459

From the Department of Surgery, Faculty of Medicine, Université Laval, Québec, Que. (Letarte, Drolet, Laliberté, Lebrun, P. Bouchard, A. Bouchard); and the Department of Colorectal Surgery, Centre hospitalier universitaire de Québec – Hôpital Saint-François d’Assise, Québec, Que. (Drolet, P. Bouchard, A. Bouchard).

Background: Transanal endoscopic microsurgery has become the standard of treatment for rectal villous adenomas. However, the role of preoperative imaging for these lesions is not clear. The aim of this study was to compare the value of preoperative imaging and surgeon clinical staging in the preoperative evaluation of patients with rectal villous adenomas having transanal endoscopic microsurgery resection. Read More

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http://dx.doi.org/10.1503/cjs.012416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6877397PMC
December 2019

Young adults and metachronous neoplasia: risks for future advanced adenomas and large serrated polyps compared with older adults.

Gastrointest Endosc 2020 03 21;91(3):669-675. Epub 2019 Nov 21.

Geisel School of Medicine at Dartmouth and Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.

Background And Aims: Recent increases in colorectal cancer (CRC) incidence in adults younger than 50 years of age have led to more colonoscopies in this age group. As a result, there may be an increasing number of adults <50 years old with polyps detected. There is concern that younger adults may require closer follow-up. Read More

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http://dx.doi.org/10.1016/j.gie.2019.11.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7039748PMC

Effect of Supplementation With Marine ω-3 Fatty Acid on Risk of Colorectal Adenomas and Serrated Polyps in the US General Population: A Prespecified Ancillary Study of a Randomized Clinical Trial.

JAMA Oncol 2019 Nov 21. Epub 2019 Nov 21.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Importance: Marine ω-3 fatty acid has been suggested to protect against colorectal cancer.

Objective: To assess the effect of daily marine ω-3 fatty acid supplementation on the risk of colorectal cancer precursors, including conventional adenomas and serrated polyps.

Design, Setting, And Participants: This study was a prespecified ancillary study of the placebo-controlled randomized clinical trial VITAL (Vitamin D and Omega-3 Trial). Read More

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http://dx.doi.org/10.1001/jamaoncol.2019.4587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902220PMC
November 2019

Microsatellite instability screening in colorectal adenomas to detect Lynch syndrome patients? A systematic review and meta-analysis.

Eur J Hum Genet 2020 Mar 6;28(3):277-286. Epub 2019 Nov 6.

Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.

The colorectal cancer spectrum has changed due to population screening programs, with a shift toward adenomas and early cancers. Whether it would be a feasible option to test these adenomas for detection of Lynch syndrome (LS) patients is unclear. Through meta-analysis and systematic review, risk factors for DNA mismatch repair deficiency (dMMR) and microsatellite instability (MSI) in adenomas were identified in LS and unselected patient cohorts. Read More

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http://dx.doi.org/10.1038/s41431-019-0538-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028913PMC

Urinary tract villous adenoma in Indonesia.

Urol Case Rep 2019 Nov 16;27:100911. Epub 2019 May 16.

Urology Department, Hasan Sadikin Hospital, University of Padjadjaran Bandung, Indonesia.

This is the first recorded case of urinary tract villous adenoma in Indonesia. A 70-years-old man suffered from a painful left flank mass and jelly like mixed urine. He had undergone percutaneous nephrostomy yielding a jelly like substance, and a previous stone surgery. Read More

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http://dx.doi.org/10.1016/j.eucr.2019.100911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6819817PMC
November 2019
1 Read

Colorectal Cancer Incidence and Mortality After Removal of Adenomas During Screening Colonoscopies.

Gastroenterology 2020 03 26;158(4):875-883.e5. Epub 2019 Sep 26.

Department of Gastroenterology, Hepatology and Clinical Oncology, Centre of Postgraduate Medical Education, Warsaw, Poland; Department of Oncological Gastroenterology and Department of Cancer Prevention, the Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.

Background & Aims: Recommendation of surveillance colonoscopy should be based on risk of colorectal cancer and death after adenoma removal. We aimed to develop a risk classification system based on colorectal cancer incidence and mortality following adenoma removal.

Methods: We performed a multicenter population-based cohort study of 236,089 individuals (median patient age, 56 years; 37. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.09.011DOI Listing
March 2020
2 Reads

The predictive value of small versus diminutive adenomas for subsequent advanced neoplasia.

Gastrointest Endosc 2020 03 13;91(3):614-621.e6. Epub 2019 Sep 13.

Division of Gastroenterology/Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Background And Aims: Patients with previous colorectal adenomas are at increased risk of colorectal cancer. Current guidelines for postpolypectomy surveillance intervals treat all tubular adenomas 1 to 9 mm in size with low-grade dysplasia as carrying the same level of risk. We evaluated whether 6 to 9 mm adenomas detected at colonoscopy are associated with greater risk of advanced neoplasia at follow-up compared with baseline 1 to 5 mm adenomas. Read More

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http://dx.doi.org/10.1016/j.gie.2019.08.047DOI Listing

Laparoscopic Pancreas-Sparing Duodenectomy with Roux en Y Reconstruction for Duodenal Polyposis.

Chirurgia (Bucur) 2019 Jul-Aug;114(4):494-505

Duodenal polyposis (DP) is often associated in patients with in patients with familial adenomatous polyposis (FAP) and the risk of malignancy is endoscopically assessed using the Spigelman score. Endoscopic therapy is the first option for PD while surgery is indicated for the advanced stages of the disease (Spiegelman III-IV). Pancreas-sparing duodenectomy (PSD) was proposed as a less aggressive alternative to pancreatoduodenectomy (PD), leaving the entire pancreas in situ while the number of anastomoses is reduced. Read More

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http://dx.doi.org/10.21614/chirurgia.114.4.502DOI Listing
October 2019
3 Reads

Endoscopic resection of a prolapsing giant villous adenoma of the supraanal rectum.

Clin Res Hepatol Gastroenterol 2020 Apr 22;44(2):121-122. Epub 2019 Aug 22.

Insitute of Pathology Saarbrücken-Rastpfuhl, Saarbrücken, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.clinre.2019.07.007DOI Listing
April 2020
2 Reads

Diagnostic Yield of One-Time Colonoscopy vs One-Time Flexible Sigmoidoscopy vs Multiple Rounds of Mailed Fecal Immunohistochemical Tests in Colorectal Cancer Screening.

Clin Gastroenterol Hepatol 2020 Mar 13;18(3):667-675.e1. Epub 2019 Aug 13.

Department of Gastroenterology and Hepatology, Erasmus University Medical Centre, Rotterdam, The Netherlands. Electronic address:

Background & Aims: We compared the diagnostic yields of colonoscopy, flexible sigmoidoscopy, and fecal immunochemical tests (FITs) in colorectal cancer (CRC) screening.

Methods: A total of 30,007 asymptomatic persons, 50-74 years old, were invited for CRC screening in the Netherlands. Participants were assigned to groups that received 4 rounds of FIT (mailed to 15,046 participants), once-only flexible sigmoidoscopy (n = 8407), or once-only colonoscopy (n = 6600). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15423565193089
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http://dx.doi.org/10.1016/j.cgh.2019.08.015DOI Listing
March 2020
3 Reads

Villous Morphology in Urinary Bladder Biopsy: An Approach to Diagnosis.

Int J Surg Pathol 2020 Feb 13;28(1):4-12. Epub 2019 Aug 13.

PGIMER, Chandigarh, India.

Villous morphology in urinary bladder biopsy is a relatively uncommon finding. Villi are slender, finger-like structures that are commonly seen in the small intestine or in neoplastic lesions of gastrointestinal lineage/differentiation. Importantly, placenta also exhibits villi that are morphologically and functionally different from the intestinal one. Read More

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http://dx.doi.org/10.1177/1066896919868527DOI Listing
February 2020
2 Reads

An Unusual Gastrointestinal Cause of Hypokalemia.

Gastroenterology 2019 12 9;157(6):1487-1489. Epub 2019 Aug 9.

Department of Pathology, Max Superspeciality Hospital, Patparganj, New Delhi, India.

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http://dx.doi.org/10.1053/j.gastro.2019.08.013DOI Listing
December 2019
1 Read

Baseline Colonoscopy Findings Associated With 10-Year Outcomes in a Screening Cohort Undergoing Colonoscopy Surveillance.

Gastroenterology 2020 03 31;158(4):862-874.e8. Epub 2019 Jul 31.

Cooperative Studies Program Epidemiology Center, Durham VA Health Care System, Durham, North Carolina; Duke University, Durham, North Carolina. Electronic address:

Background & Aims: Few studies have evaluated long-term outcomes of ongoing colonoscopic screening and surveillance in a screening population. We aimed to determine the 10-year risk for advanced neoplasia (defined as adenomas ≥10mm, adenomas with villous histology or high-grade dysplasia, or colorectal cancer [CRC]) and assessed whether baseline colonoscopy findings were associated with long-term outcomes.

Methods: We collected data from the Department of Veterans Affairs Cooperative Studies Program Study on 3121 asymptomatic veterans (50-75 years old) who underwent a screening colonoscopy from 1994 through 1997 at 13 medical centers and were then followed for 10 years or until death. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.07.052DOI Listing
March 2020
2 Reads

Non-conventional mucosal lesions (serrated epithelial change, villous hypermucinous change) are frequent in patients with inflammatory bowel disease-results of molecular and immunohistochemical single institutional study.

Virchows Arch 2020 Feb 2;476(2):231-241. Epub 2019 Aug 2.

The Fingerland Department of Pathology, Charles University Faculty of Medicine and University Hospital Hradec Králové, Sokolská 581, 500 03, Hradec Králové, Czech Republic.

Chronically inflamed mucosa in inflammatory bowel disease (IBD) is associated with an increased risk of cancer. Besides IBD-associated dysplasia, there are non-conventional mucosal changes that may act as potential precursors. The aim of the study was to retrospectively review samples from IBD patients focusing on detection of such lesions with evaluation of their immunohistochemical and molecular properties. Read More

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http://dx.doi.org/10.1007/s00428-019-02627-4DOI Listing
February 2020
4 Reads

Tubulo-villous adenoma of the appendix: A case report and review of the literature.

Int J Surg Case Rep 2019 16;61:60-63. Epub 2019 Jul 16.

General Surgery Department, San Salvatore Hospital, Paternò, Catania, Italy.

Introduction: Tubulo-villous adenoma is a rare benign appendiceal neoplasm often asymptomatic with the most clinical manifestation that resembles acute appendicitis. Pre-operative diagnosis is difficult by its rarity and the absence of typical symptoms. Adequate treatment is surgical resection. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.06.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6658925PMC
July 2019
5 Reads

Adult with intestinal malrotation and colocolic intussusception: an unusual combo.

BMJ Case Rep 2019 Jul 22;12(7). Epub 2019 Jul 22.

General Medicine, Noble Hospital & Research Centre, Pune, India.

Intestinal malrotation is a congenital anomaly that results from an abnormality in the rotation and fixation of the gut as it returns to the abdominal cavity during development. Intussusception is a condition characterised by telescoping of one segment of the bowel into another segment. The combination of malrotation and intussusception is frequently a cause of intestinal obstruction in the paediatric age group. Read More

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http://dx.doi.org/10.1136/bcr-2018-226398DOI Listing
July 2019
3 Reads

Clinicopathological characteristics of non-ampullary duodenal tumors and their phenotypic classification.

Pathol Int 2019 Jul 21;69(7):398-406. Epub 2019 Jul 21.

Division of Pathology, Shizuoka Cancer Center, Shizuoka, Japan.

The tumorigenesis of non-ampullary duodenal epithelial tumors (NADETs) might be different between the oral and anal sides of Vater's papilla. We conducted an immunohistological review to elucidate the clinicopathological features according to the tumor location and phenotypic classification. A review of an institutional database identified 121 patients with 125 superficial NADETs. Read More

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http://dx.doi.org/10.1111/pin.12829DOI Listing
July 2019
2 Reads

Small Intestinal Tumors: A Rare Case of Tubulovillous Adenoma in Duodenum.

Cureus 2019 May 15;11(5):e4671. Epub 2019 May 15.

Hematology and Oncology, The University of Arizona, Tucson, USA.

The small intestine is a relatively privileged organ; primary tumors are uncommon among malignancies of the gastrointestinal tract, with an average annual incidence rate of 9.9 per million people. Among these uncommon tumors, duodenal tumors are even rarer with an average incidence rate of 0. Read More

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http://dx.doi.org/10.7759/cureus.4671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634277PMC
May 2019
7 Reads

Long-term Risk of Colorectal Cancer After Removal of Conventional Adenomas and Serrated Polyps.

Gastroenterology 2020 03 11;158(4):852-861.e4. Epub 2019 Jul 11.

Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Electronic address:

Background & Aims: Endoscopic screening reduces incidence and mortality of colorectal cancer (CRC) because precursor lesions, such as conventional adenomas or serrated polyps, are removed. Individuals with polypectomies are advised to undergo colonoscopy surveillance to prevent CRC. However, guidelines for surveillance intervals after diagnosis of a precursor lesion, particularly for individuals with serrated polyps, vary widely, and lack sufficient supporting evidence. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.06.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954345PMC
March 2020
3 Reads

[A case of rectal villous adenoma with electrolyte depletion syndrome treated with surgical resection].

Nihon Shokakibyo Gakkai Zasshi 2019 ;116(7):576-582

Division of Gastroenterology, Showa University.

A 65-year-old man was previously admitted to our university hospital thrice in the last 2 years because of acute kidney failure. This time he was admitted because of frequent diarrhea, anorexia, exacerbation of renal function, and hyponatremia. Rectal wall thickening was detected on computed tomography. Read More

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http://dx.doi.org/10.11405/nisshoshi.116.576DOI Listing
August 2019
4 Reads

Comparison of the Uptake of Screening Colonoscopy between Physicians and the General Population in Greece.

Dig Dis 2020 9;38(1):23-30. Epub 2019 Jul 9.

Department of Gastroenterology, Evangelismos General Hospital, Athens, Greece.

Aim: To evaluate the uptake of screening colonoscopy among physicians as compared to the general population.

Methods: Asymptomatic physicians, aged 45-67 years, at average risk for colorectal cancer (CRC), working in the participating National Health System hospitals were asked to complete a questionnaire regarding the uptake of screening colonoscopy. The results were compared to those in a background healthy population, aged 50-75 years, inhabitants of a Greek county, who were offered a free access to a screening colonoscopy program for CRC. Read More

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http://dx.doi.org/10.1159/000501266DOI Listing

Clinicopathologic Features of Colorectal Polyps in Shahid Beheshti University of Medical Sciences (SBMU).

Asian Pac J Cancer Prev 2019 06 1;20(6):1773-1780. Epub 2019 Jun 1.

Department of Pathology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Email:

Aim: This study was designed to report epidemiologic findings of polyps in Iranian patients, and predict histology of polyp regarding to demographic and colonoscopic findings. Background: Classification of colorectal polyps had been revised in the past two decades and there is a need for polyp categorization in the Iranian Health System. Patients and methods: In this retrospective study, the medical records of patients with colonoscopic diagnosis of polyp in pathology departments of SBMU affiliated teaching hospitals were reviewed. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.6.1773DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021591PMC
June 2019
7 Reads

The Kraske procedure: no more indications for benign lesions?

Tech Coloproctol 2019 06 26;23(6):607-608. Epub 2019 Jun 26.

Colorectal Unit, Department of Surgery, Michallon University Hospital Grenoble, CS 10217, Grenoble Cedex, 38043, France.

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http://dx.doi.org/10.1007/s10151-019-02005-xDOI Listing

Giant villous adenoma of rectum- what is the malignant potential and what is the optimal treatment? A case and review of literature.

World J Surg Oncol 2019 Jun 25;17(1):109. Epub 2019 Jun 25.

Department of Pathology, Maulana Azad Medical College, New Delhi, India.

Introduction: Villous adenomas are dubiously benign lesions, which are difficult to interpret because of their malignant potential. Distal villous adenomas present with bleeding or mucus discharge. Giant adenomas are not amenable for endoscopic or transanal resection. Read More

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http://dx.doi.org/10.1186/s12957-019-1650-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593568PMC
June 2019
5 Reads

CD204-Positive Tumor-associated Macrophages Relate to Malignant Transformation of Colorectal Adenoma.

Anticancer Res 2019 Jun;39(6):2767-2775

Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Background/aim: Colorectal adenoma is well known as a precursor lesion of colorectal adenocarcinoma (ADC). We recently reported the significance of CD204 (+) tumor-associated macrophages (TAMs), a vital component of the tumor microenvironment, in the carcinoma development of gastric adenoma. The aim of the present study was to clarify the roles of TAM in the malignant transformation of colorectal adenoma. Read More

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http://dx.doi.org/10.21873/anticanres.13403DOI Listing
June 2019
8 Reads

Endoscopic removal of tubulovillous adenoma with high grade focal dysplasia in the distal common bile duct.

Endoscopy 2019 11 4;51(11):E319-E320. Epub 2019 Jun 4.

Department of Gastroenterology, Hospital Universitari MútuaTerrassa, Fundació per la Recerca Mútua Terrassa, Terrassa, Catalonia Spain.

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http://dx.doi.org/10.1055/a-0915-1638DOI Listing
November 2019
1 Read
5.053 Impact Factor

Association of small versus diminutive adenomas and the risk for metachronous advanced adenomas: data from the New Hampshire Colonoscopy Registry.

Gastrointest Endosc 2019 09 22;90(3):495-501. Epub 2019 May 22.

Medicine, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA; New Hampshire Colonoscopy Registry, Lebanon, New Hampshire, USA.

Background And Aims: Limited data are available to investigate the impact of index adenoma size on the risk of metachronous advanced adenomas. Our goal was to examine the impact of having small (5-9 mm) versus diminutive (<5 mm) adenomas on the future risk of advanced adenomas within the categories for polyps <1 cm currently used in the United States: 1 to 2 and 3 or more tubular adenomas.

Methods: We included data from individuals participating in the statewide, population-based New Hampshire Colonoscopy Registry (NHCR). Read More

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http://dx.doi.org/10.1016/j.gie.2019.05.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707852PMC
September 2019
5 Reads