11,482 results match your criteria Villous Adenoma
Rom J Morphol Embryol 2018 ;59(3):715-720
Department of Anesthesiology and Intensive Care, University of Medicine and Pharmacy of Craiova, Romania; Research Center for Microscopic Morphology and Immunology, University of Medicine and Pharmacy of Craiova, Romania;
Objective: Placental lesions and placental ischemia are typical elements of intrauterine growth restriction (IUGR). The aim of this study is to analyze histological and immunohistochemical (IHC) changes in the placentas of IUGR fetuses.
Materials And Methods: In this prospective study, 126 placentas from small for gestational age (SGA) pregnancies (newborns with birth weight <10th percentile) that formed the study group and 31 placentas from pregnancies without SGA representing control group, were included. Read More
Eur J Intern Med 2018 Dec 5. Epub 2018 Dec 5.
Institute for Translational Immunology, Research Center for Immunotherapy (FZI), Johannes Gutenberg University (JGU) Medical Center, 55101 Mainz, Germany; Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Celiac disease (CD) is the most common autoimmune enteropathy worldwide. In CD, dietary gluten triggers a T cell driven small intestinal inflammation in a subset of genetically predisposed subjects, expressing the HLA DQ2 and/or DQ8 genes on their antigen presenting cells. HLA DQ2/DQ8 can bind gluten peptides after their prior modification by the CD autoantigen, tissue transglutaminase (TG2). Read More
J Obstet Gynaecol Res 2018 Dec 6. Epub 2018 Dec 6.
Department of Obstetrics and Gynecology, Gifu Prefectural Tajimi Hospital, Tajimi, Japan.
A 41-year-old woman (gravida 2, para 1) underwent elective termination of pregnancy at approximately 7 weeks of gestation. At 1 month after the elective abortion, she was referred due to abnormal results in a cervical cytological examination. Transvaginal ultrasonography showed a heterogeneous mass of 16 mm in diameter in the left adnexal region. Read More
Int J Hematol 2018 Dec 5. Epub 2018 Dec 5.
Department of Pathology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Biochem Biophys Res Commun 2018 Nov 28. Epub 2018 Nov 28.
Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China. Electronic address:
Problem: Recurrent spontaneous abortion (RSA) is associated with immune imbalance at the maternal-fetal interface. Decidual immune cells and cytokines expressed at this interface regulate the response of the maternal immune system to the fetus. However, the populations and cytokine expression levels of these lymphocytes in miscarriage with normal and abnormal chromosome karyotypes remain unclear. Read More
Zhongguo Shi Yan Xue Ye Xue Za Zhi 2018 Dec;26(6):1811-1815
Shanghai Institute of Hematology，Ruijin Hospital Affiliated Shanghai Jiaotong University School of
Objective: To investigate the charactcristics of CD180 expression and differentiation diagnostic value in B cell chronic lymphoproliferative disorders (B-CLPD) through detecting the mean fluorescence intensity（MFI）of CD180 in different sub types of B-CLPD，using multiparameter flow cytometry (FCM).
Methods: The CD180 MFI of malignant B cells in 178 patients with B-CLPD was detected by FCM. The level of CD180 MFI in various types of B-CLPD was compared to the normal control group. Read More
Rev Esp Enferm Dig 2018 Dec 4;111. Epub 2018 Dec 4.
Anatomía Patológica, Hospital Universitario La Paz, España.
Mycophenolate mofetil (MMF) is an immunosuppressive agent that is used in transplanted patients, with frequent gastrointestinal adverse effects. We report the case of a patient, under chronic therapy with mycophenolate mofetil , during a diagnostic workup for a chronic diarrhea, which presents a duodenal villous atrophy ( VA) with negative celiac serology, which is a diagnostic challenge. VA secondary to MMF is a very unusual adverse effect. Read More
Arch Pathol Lab Med 2018 Dec;142(12):1485-1502
From the Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland.
Context.—: Distinction of hydatidiform moles from nonmolar specimens and subclassification of hydatidiform moles as complete hydatidiform mole versus partial hydatidiform mole are important for clinical practice and investigational studies. Risk of persistent gestational trophoblastic disease and clinical management differ for these entities. Read More
Front Immunol 2018 15;9:2628. Epub 2018 Nov 15.
Department of Comparative Biosciences, Wisconsin National Primate Research Center, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, United States.
Hofbauer cells are placental villous macrophages of fetal origin that are present throughout pregnancy. Although Hofbauer cell populations are antigenically and morphologically heterogeneous, their epigenetic, antigenic, and functional profiles most closely resemble alternatively activated macrophages or what are referred to as M2a, M2b, M2c, and M2d polarity subtypes. Consistent with an M2-like profile, these cells play an important role in placental development including vasculogenesis and angiogenesis. Read More
Nature 2018 12 28;564(7735):263-267. Epub 2018 Nov 28.
Department of Pathology, University of Cambridge, Cambridge, UK.
The placenta is the extraembryonic organ that supports the fetus during intrauterine life. Although placental dysfunction results in major disorders of pregnancy with immediate and lifelong consequences for the mother and child, our knowledge of the human placenta is limited owing to a lack of functional experimental models. After implantation, the trophectoderm of the blastocyst rapidly proliferates and generates the trophoblast, the unique cell type of the placenta. Read More
JGH Open 2018 Oct 2;2(5):196-200. Epub 2018 Aug 2.
Department of Gastroenterology Postgraduate Institute of Medical Education and Research Chandigarh India.
Background And Aims: Anemia is one of the most common extraintestinal manifestations of celiac disease (CD), with iron deficiency anemia (IDA) being the predominant cause. However, anemia in CD can have varied etiologies, including mixed nutritional deficiency. We aimed to study the prevalence and etiology of anemia in CD in a north Indian population. Read More
Saudi J Gastroenterol 2018 Nov 27. Epub 2018 Nov 27.
Division of Gastroenterology, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.
Background/aims: Colorectal cancer is the most common cancer in males and the third most common cancer in females. We aim to determine the polyp and adenoma prevalence in a cohort of patients who underwent opportunistic screening colonoscopies.
Patients And Methods: A retrospective cohort study was conducted using an endoscopic reporting database of individuals seen at three tertiary care hospitals (two public hospitals and one private) in Riyadh, Saudi Arabia. Read More
Cancer Epidemiol Biomarkers Prev 2018 Nov 20. Epub 2018 Nov 20.
Kaiser Permanente Washington Health Research Institute, Seattle, Washington.
To reduce colorectal cancer incidence and mortality, experts recommend surveillance colonoscopy 3 years after advanced adenoma removal. Little is known about adherence to that interval. We describe patterns of and factors associated with subsequent colonoscopy among persons with ≥3 adenomas and/or ≥1 adenoma with villous/tubulovillous histology in four U. Read More
Reprod Sci 2018 Nov 20:1933719118812739. Epub 2018 Nov 20.
1 Department of Cellular and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
The use of immunosuppressive drugs guarantees the vitality of the graft and allows gestation in spite of intercurrences such as prematurity and intrauterine growth restriction. However, little is known about the direct effects of immunosuppressive drugs on placental cells. We investigated the effects of immunosuppressive drugs in the chorionic villous explants from human term placentas of healthy gestations. Read More
Probiotics Antimicrob Proteins 2018 Nov 19. Epub 2018 Nov 19.
Department of Food Hygiene and Public Health, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
Heavy metals naturally occur in the environment and are causing great concern all around the world. Accumulation of heavy metals in fish tissues can lead to serious adverse effects in humans when consumed in the amounts exceeding the safe consumption levels. In this study, Lactobacillus fermentum 1744 (ATCC 14931) and lactulose were used in the fish diet in order to investigate their effects on growth performance, intestinal villous morphology, and heavy metals residues. Read More
Nutrients 2018 Nov 18;10(11). Epub 2018 Nov 18.
Division of Gastroenterology, Infectious Diseases and Rheumatology, Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, 12203 Berlin, Germany.
The gluten-free diet is the only effective treatment available for celiac disease. However, it is difficult to adhere to and a closer look on the diet's implementation and indications reveals several ambiguities: Not only is there controversy on the threshold of gluten that can be tolerated in the frame of a strict gluten-free diet, but it is also unclear whether the gluten-free diet is an appropriate treatment in patient subgroups with asymptomatic or potential celiac disease. Reports from a number of research groups suggest that a certain proportion of patients may effectively develop tolerance to gluten and thus become suitable for gluten reintroduction over time. Read More
J Ultrason 2018 ;18(74):212-223
Leeds Teaching Hospitals and Leeds University, Leeds, UK.
There are numerous abnormalities that present with similar signs and symptoms to arthritis. In this article some of these conditions that can masquerade as arthritis are discussed. Synovial osteochondromatosis is an uncommon benign disorder marked by the metaplastic proliferation of multiple cartilaginous nodules in the synovial membrane of the joints, bursae, or tendon sheaths. Read More
Clin Gastroenterol Hepatol 2018 Nov 15. Epub 2018 Nov 15.
Professor of Medicine, Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN. Electronic address:
Background And Aims: A higher proportion of female vs male patients receive a diagnosis of celiac disease. Little is known about sex-based differences in the prevalence of celiac disease in undiagnosed populations. We aimed to address this knowledge gap with a systematic review and meta-analysis. Read More
Cas Lek Cesk 2018 ;157(3):117-121
Celiac disease can be defined as a small bowel disorder characterized by mucosal inflammation, villous atrophy and crypt hyperplasia, which occurs upon exposure to dietary gluten and which demonstrates improvement after withdrawal of gluten from the diet. Keywords: celiac disease, children, adolescents. Read More
Clin Endosc 2018 Nov 16;51(6):570-575. Epub 2018 Nov 16.
Gastroenterology and Endoscopy Division, Instituto Ecuatoriano de Enfermedades Digestivas (IECED), Guayaquil, Ecuador.
Background/aims: Capsule endoscopy is a diagnostic method for evaluating the small bowel lumen and can detect undiagnosed lesions. The aim of this study was to evaluate the diagnostic yield and clinical impact of capsule endoscopy in patients with refractory diarrhea-predominant irritable bowel syndrome and functional abdominal pain.
Methods: This study involved a retrospective analysis of prospectively collected data, maintained in a database. Read More
J Cell Physiol 2018 Nov 13. Epub 2018 Nov 13.
Department of Experimental and Clinical Medicine, Università Politecnica delle Marche, Ancona, Italy.
Pre-eclampsia (PE) is a multisystem disorder commonly diagnosed in the latter half of pregnancy and it is a leading cause of intrauterine fetal growth retardation (IUGR). The aim of this study was to investigate the localization and the role of SPARC, secreted protein acidic, and rich in cysteine, in PE and PE-IUGR placentas in comparison with normal placentas. SPARC was mainly expressed in the villous and extravillous cytotrophoblastic cells in first trimester, whereas in PE, PE-IUGR and at term placentas, SPARC immunostaining was visible in both cytotrophoblastic cells and syncytiotrophoblast. Read More
Front Physiol 2018 30;9:1507. Epub 2018 Oct 30.
Laboratorio de Biología de la Reproducción, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO)-UBA-CONICET, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Accumulated evidence suggests that an abnormal placentation and an altered expression of a variety of trophoblast transporters are associated to preeclampsia. In this regard, an abnormal expression of AQP3 and AQP9 was reported in these placentas. Recent data suggests that placental AQPs are not only water channel proteins and that may participate in relevant processes required for a normal placental development, such as cell migration and apoptosis. Read More
Placenta 2018 Nov 4;71:16-23. Epub 2018 Oct 4.
Vascular Immunology Research Laboratory, The Heart Research Institute, University of Sydney, Camperdown, NSW, Australia; School of Medicine, Western Sydney University, NSW, 2751, Australia.
Introduction: Cigarette smoking (CS) and preeclampsia (PE), regulate the expression of nicotinic acetylcholine receptor (nAChR) subunits in the placenta, yet no data exist at the histological level.
Methods: Using immunohistochemistry of formalin fixed and paraffin embedded placental tissue, this study quantified the expression of nine nAChR subunits (α2, α3, α4, α5, α7, α9, β1, β2, δ) and compared the expression amongst four groups of non-smoker non-PE (controls, n = 8), smokers (n = 8), PE (n = 8), and those who were smokers with PE (smoke + PE, n = 4). Quantification was of the percentage of villi with positive cells stained (% villi with +ve), percentage of positive stained cells per villous (% +ve cells/villous), percentage of positive cells in the decidua (%+ve Decidua), and intensity of staining in the outer villous trophoblast layer. Read More
PLoS One 2018 8;13(11):e0206725. Epub 2018 Nov 8.
Department of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center, Medical University of Graz, Graz, Austria.
Background: Preeclampsia and intra-uterine growth restriction (IUGR) are major health problems during pregnancy affecting both mother and child. Defective placental development and failure of trophoblast differentiation during pregnancy are important aspects in the pathogenesis of both syndromes. Recent studies have shown that autophagy is involved in the trophoblast survival capacity. Read More
Oncol Lett 2018 Nov 20;16(5):6458-6464. Epub 2018 Sep 20.
Jiangxi Provincial Key Laboratory of Reproductive Physiology and Pathology, Department of Physiology, School of Medicine, Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Uterine natural killer (uNK) cells have been hypothesized to serve a role in controlling trophoblast invasion and proliferation. The aim of the present study was to identify the distribution and number of uNK cells in normal pregnancy (NP), partial mole (PM), complete mole (CM) and invasive mole (IM). uNK cells were detected using dolichos biflorus agglutinin lectin immunohistochemistry in decidual and villous tissues from early NP (n=15), late NP (n=15), PM (n=22), CM (n=20) and IM (n=10). Read More
Sci Adv 2018 Oct 31;4(10):eaau4788. Epub 2018 Oct 31.
Department of Obstetrics and Gynecology, Columbia University Medical Center, 630 W 168th St., New York, NY 10032, USA.
The placenta and decidua interact dynamically to enable embryonic and fetal development. Here, we report single-cell RNA sequencing of 14,341 and 6754 cells from first-trimester human placental villous and decidual tissues, respectively. Bioinformatic analysis identified major cell types, many known and some subtypes previously unknown in placental villi and decidual context. Read More
Br J Nutr 2018 Nov;120(10):1131-1148
1Department of Animal Science,University of California,One Shields Avenue,Davis,CA 95616,USA.
Malnutrition remains a leading contributor to the morbidity and mortality of children under the age of 5 years and can weaken the immune system and increase the severity of concurrent infections. Livestock milk with the protective properties of human milk is a potential therapeutic to modulate intestinal microbiota and improve outcomes. The aim of this study was to develop an infection model of childhood malnutrition in the pig to investigate the clinical, intestinal and microbiota changes associated with malnutrition and enterotoxigenic Escherichia coli (ETEC) infection and to test the ability of goat milk and milk from genetically engineered goats expressing the antimicrobial human lysozyme (hLZ) milk to mitigate these effects. Read More
Int J Gynecol Pathol 2018 Nov 1. Epub 2018 Nov 1.
Sinai Health System (R.A., T.J.C.); The Sinai Health System and University of Toronto (M.C.C.), Toronto, Ontario, Canada.
The use of p57 immunohistochemistry (IHC) can distinguish complete mole (CM) from partial mole (PM) and nonmolar abortus (NMA). Molecular genotyping (MG) is the gold standard method for the definitive diagnosis of PM and NMA. However, MG is expensive and not always available. Read More
J Carcinog Mutagen 2018 11;9(2). Epub 2018 Sep 11.
Department of Medicine, Morehouse School of Medicine, 720 Westview Dr. SW Atlanta, GA 30310-1495, USA.
Objective: Colorectal cancer (CRC) develops from precancerous adenomatous polyps to malignant lesions of adenocarcinoma. Elucidating inhibition mechanisms for this route in patients with a risk of developing CRC is highly important for a potential diagnostic or prognostic marker. Differential expression of nuclear-encoded cytochrome c oxidase subunit 4 (COXIV) seems to contribute to a more unregulated respiration due to loss of ATP inhibition. Read More
Prostaglandins Leukot Essent Fatty Acids 2018 Nov 4;138:24-29. Epub 2018 Oct 4.
Human Development and Health, Faculty of Medicine, University of Southampton, MP 887, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, United Kingdom; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, United Kingdom.
The human foetus depends on placental transfer for the fatty acids required for its growth and development. Long chain polyunsaturated fatty acids (LC-PUFAs) may specifically influence neurodevelopment. Therefore, it is important to understand the mechanisms of placental transfer of LC-PUFAs. Read More
BMC Gastroenterol 2018 Nov 3;18(1):162. Epub 2018 Nov 3.
Gastroenterology and Gastrointestinal Endoscopy Unit, Sant'Andrea University Hospital, "Sapienza" University of Rome, Rome, Italy.
Background: The diagnosis of Coeliac disease (CD) requires a combination of sign/symptoms, positivity of specific antibodies and duodenal histological evidence of villous atrophy. Duodenal villous atrophy, despite representing the CD landmark, is not specific since it is found in many gastrointestinal disorders. Giardiasis is one of the most common human intestinal protozoan infestations in industrialized countries whose histological duodenal mucosa damage could mimic that of CD. Read More
BMJ Case Rep 2018 Nov 1;2018. Epub 2018 Nov 1.
Department of Paediatric Surgery, Christian Medical College and Hospital Vellore, Vellore, Tamil Nadu, India.
A 5-year-old boy with metachromatic leukodystrophy, debilitated by spastic quadriparesis presented to us with massive ascites and respiratory distress. A subtotal cholecystectomy was performed on him from another centre for a gall bladder mass a year before he came to us. Imaging revealed a polypoidal frond-like mass arising from the gall bladder fossa which was supplied by a hypertrophied branch of the right hepatic artery. Read More
Am J Gastroenterol 2018 Nov 1. Epub 2018 Nov 1.
The Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Background And Aims: Serrated polyps (SPs) and conventional high-risk adenomas (HRAs) derive from two distinct biological pathways but can also occur synchronously. Adults with synchronous SPs and adenomas have been shown to be a high-risk group and may have a unique risk factor profile that differs from adults with conventional HRAs alone. We used the population-based New Hampshire Colonoscopy Registry (NHCR) to examine the risk profile of individuals with synchronous conventional HRAs and SPs. Read More
BMC Dev Biol 2018 Nov 1;18(1):19. Epub 2018 Nov 1.
Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Dr, University of Saskatchewan, Saskatoon, SK, S7N 5B4, Canada.
Background: Integrins are transmembrane receptors that mediate cell-extracellular matrix (ECM) and cell-cell adhesion and trophoblast cells undergo changes in integrin expression as they differentiate. However, the mechanism(s) of integrin activation leading to integrin-mediated signaling in trophoblast cell differentiation is unknown. The Fermitin family proteins are integrin activators that help mediate integrin-mediated signaling, but have never been studied in detail within the human placenta. Read More
Curr Pharm Biotechnol 2018 10 29. Epub 2018 Oct 29.
Animal Resource Science Center Graduate School of Agricultural and Life Sciences, The University of Tokyo. Japan.
The invasion of an extravillous trophoblast (EVT) into maternal decidual tissues, especially toward maternal spiral arteries, is an essential process in human placental formation and subsequent normal fetal development. However, the precise regulatory mechanisms to induce EVT invasion toward arteries and/or to protect EVT from further invasion are not well understood. We found that a chemokine receptor, CCR1, was specifically expressed on EVT migrating toward maternal arteries. Read More
Biotechniques 2018 Oct 29. Epub 2018 Oct 29.
Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, OR, USA.
Geometry of the placental villous vasculature is a key determinant of maternal-fetal nutrient exchange for optimal fetal growth. Recent advances in tissue clarification techniques allow for deep high-resolution imaging with confocal microscopy; however, the methodology lacks a signal:noise ratio of sufficient magnitude to allow for quantitative analysis. Thus, we sought to develop a reproducible method to investigate the 3D vasculature of the nonhuman primate placenta for subsequent data analysis. Read More
Zhonghua Wei Chang Wai Ke Za Zhi 2018 Oct;21(10):1161-1166
Endoscopy Center, The Affiliated Wuxi Second People's hospital of Nanjing Medical University, Jiangsu 214002, China.Email:
Objective: To analyze the risk factors of carcinogenesis of large colorectal polyps (diameter ≥ 10 mm) found by colonoscopy.
Methods: Clinicopathological and follow-up data of 418 consecutive patients who were diagnosed as colorectal polyps with diameter≥10 mm by colonoscopy at two endoscopy centers of the Affiliated Wuxi Second People's Hospital, Nanjing Medical University (n=207) and Zhongshan Hospital, Fudan University (n=211) from January 2015 to December 2016 were retrospectively collected. High-grade intraepithelial neoplasia and cancer were defined as malignancy in this study. Read More
Eat Weight Disord 2018 Oct 27. Epub 2018 Oct 27.
Pediatric Endocrine and Diabetes Unit, Chaim Sheba Medical Center, Ramat-Gan, Israel.
Purpose: Celiac disease (CD) is a chronic immune-mediated systemic disease characterized by inflammation and villous atrophy of the small intestine. A strict, lifelong gluten-free diet (GFD) is the only treatment for CD. Disordered eating behaviors (DEBs) prevail in adolescence and young adulthood, and confer a risk of developing into full-blown eating disorders. Read More
Endoscopy 2018 10 25. Epub 2018 Oct 25.
Academic Department of Gastroenterology and Hepatology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Trust, Sheffield, United Kingdom.
Background: Small-bowel capsule endoscopy is advocated and repeat upper gastrointestinal (GI) endoscopy should be considered for evaluation of recurrent or refractory iron deficiency anemia (IDA). A new device that allows magnetic steering of the capsule around the stomach (magnetically assisted capsule endoscopy [MACE]), followed by passive small-bowel examination might satisfy both requirements in a single procedure.
Methods: In this prospective cohort study, MACE and esophagogastroduodenoscopy (EGD) were performed in patients with recurrent or refractory IDA. Read More
Urology 2018 Oct 23. Epub 2018 Oct 23.
Department of Urology, Dubai Hospital, Dubai, United Arab Emirates.
Intestinal metaplasia of the urinary bladder can occur within the surface urothelium due to chronic irritation in repaired exstrophic urinary bladder. Colonic villous adenomas and tubulovillous adenomas with high-grade dysplasia and associated adenocarcinoma have been reported in adult patients with a history of augmented exstrophic bladder. To our knowledge, we report the first example of a nonadenomatous serrated hyperplastic colonic polyp in an elderly patient with a history of exstrophic bladder. Read More
Bull Exp Biol Med 2018 Oct 23;165(6):793-797. Epub 2018 Oct 23.
V. I. Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation, Moscow, Russia.
The expression of microRNA-17, microRNA-181a, and microRNA-519a in the villous tree in preeclampsia was analyzed using chromogenic in situ hybridization technique (CISH). It was found that in early-onset preeclampsia, the expression of microRNA-17 in the syncytiotrophoblast was higher (p<0.05) than in late preeclampsia, and the expression of microRNA-519a was higher (p<0. Read More
Proc Natl Acad Sci U S A 2018 11 22;115(45):E10539-E10547. Epub 2018 Oct 22.
Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712;
The initiation of intestinal inflammation involves complex intercellular cross-talk of inflammatory cells, including the epithelial and immune cells, and the gut microbiome. This multicellular complexity has hampered the identification of the trigger that orchestrates the onset of intestinal inflammation. To identify the initiator of inflammatory host-microbiome cross-talk, we leveraged a pathomimetic "gut inflammation-on-a-chip" undergoing physiological flow and motions that recapitulates the pathophysiology of dextran sodium sulfate (DSS)-induced inflammation in murine models. Read More
In Vivo 2018 Nov-Dec;32(6):1473-1475
Gastrointestinal and Liver Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital Stockholm, Stockholm, Sweden
Background: The finding was recently reported of clusters of colonic crypts lined with indigenous normal epithelium displaying irregular shapes underneath the adenomatous glands of conventional (tubular or villous) adenomas. These abnormal crypts were named non-dysplastic corrupted colonic crypts (NDCs). This study explored the characteristics of cell proliferation in NDCs present in a cohort of conventional adenomas. Read More
Biochem Biophys Res Commun 2018 Nov 19;506(1):237-242. Epub 2018 Oct 19.
University of Southampton, Faculty of Medicine, UK; University of Southampton, Institute for Life Science, UK. Electronic address:
Organic anion transporters (OATs) and organic anion transporting polypeptides (OATPs) are transport proteins that mediate exchange of metabolites, hormones and waste products. Directional transport by these transporters can occur when exchange is coupled to the gradients of other substrates. This study investigates whether the activity of OATP4A1 and OATP2A1 on the maternal facing microvillus membrane of the placental syncytiotrophoblast is coupled to the glutamate gradient. Read More
Gastroenterology 2018 Oct 17. Epub 2018 Oct 17.
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA. Electronic address:
Background And Aims: Celiac disease has characteristics of an autoimmune disease, such as increased antibody levels to tissue transglutaminase (tTG). However, assays to measure these biomarkers in blood samples do not identify patients with sufficient accuracy for diagnosis or monitoring of celiac disease. We aimed to discover biomarkers of celiac disease derived from neoepitopes of deamidated gliadin peptides (DGP) and tTG fragments and to determine if immune reactivity against these epitopes can identify patients with celiac disease with mucosal healing. Read More
Front Microbiol 2018 25;9:2266. Epub 2018 Sep 25.
Laboratório de Virologia Molecular, Instituto Carlos Chagas, Fundação Oswaldo Cruz, Curitiba, Brazil.
Zika virus (ZIKV) infection in humans has been associated with congenital malformations and other neurological disorders, such as Guillain-Barré syndrome. The mechanism(s) of ZIKV intrauterine transmission, the cell types involved, the most vulnerable period of pregnancy for severe outcomes from infection and other physiopathological aspects are not completely elucidated. In this study, we analyzed placental samples obtained at the time of delivery from a group of 24 women diagnosed with ZIKV infection during the first, second or third trimesters of pregnancy. Read More
Am J Surg Pathol 2018 Oct 16. Epub 2018 Oct 16.
Departments of Pathology.
Refractory celiac disease (RCD) is a rare condition, usually managed at specialized centers. However, gastroenterologists and pathologists in general practices are often the first to consider a diagnosis of RCD in celiac patients with persistent symptoms. The distinction between type I and type II RCD is crucial as patients with RCD II have a shortened life expectancy. Read More
Pediatr Dev Pathol 2018 Oct 18:1093526618801616. Epub 2018 Oct 18.
4 Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
Fetal bacterial infections are a common cause of fetal/neonatal morbidity and mortality. The pathologic correlates of congenital bacterial infection include acute chorioamnionitis, acute villitis, and acute intervillositis. The strength of the association of congenital bacterial infection differs among these pathologies. Read More
Obstet Gynecol Int 2018 20;2018:9462938. Epub 2018 Sep 20.
Department of Histopathology, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Nigeria.
Objective: To determine the pattern of pathological changes in placentas of preeclamptic/eclamptic parturients and its correlation with the clinical severity as well as the perinatal outcome.
Methods: A cross-sectional analytical study of placental pathologies in preeclamptic/eclamptic patients was performed in a blinded pattern and compared with matched normal controls. Data were analyzed using Epi-Info 2008 version 3. Read More
Ann R Coll Surg Engl 2018 Oct 16:1-7. Epub 2018 Oct 16.
North Bristol NHS Trust , UK.
Introduction: McKittrick-Wheelock syndrome describes the condition of extreme electrolyte and fluid depletion caused by large distal colorectal tumours, usually the benign villous adenoma. Patients generally present critically unwell with severe hyponatraemia, hypokalaemia and/or acute kidney injury.
Methods: A structured literature review was undertaken to discover what is known about this condition, which is almost universally described as rare. Read More