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Lancet Glob Health 2022 Jul;10(7):e1012-e1022

African Research Group for Oncology, Osun, Nigeria; Department of Surgery, and Global Cancer Disparities Initiative, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address:

Background: The estimated incidence of colorectal cancer is rising in Nigeria, where most patients present with advanced disease. Earlier detection of colorectal cancer is a goal of the Nigerian National Cancer Control Plan, but the utility of fecal-based screening is unclear. This study aimed to assess the fecal immunochemical test as a colorectal cancer screening modality in average-risk individualS in Nigeria. Read More

Rom J Morphol Embryol 2021 Oct-Dec;62(4):917-928

Department of Gastroenterology, University of Medicine and Pharmacy of Craiova, Romania;

Colorectal carcinoma represents a major cause of mortality and 0.2-12% of resected colonic polyps have malignant cells inside. We performed a retrospective study of patients with resected polyps during a period of 13 years. Read More

Int J Surg Case Rep 2022 Jun 10;95:107176. Epub 2022 May 10.

Department of General Surgery, The First Hospital of Jiaxing (The First Affiliated Hospital of Jiaxing University), Jiaxing, Zhejiang 314001, PR China.

Introduction And Importance: Primary hepatic neuroendocrine tumors (PHNETs) are extremely rare, and the clinical symptoms, test results, and imaging characteristics are nonspecific in most patients; thus, it is difficult to differentiate from other liver masses before surgery. Histopathology and immunohistochemistry are the main basis for the diagnosis. PHNETs and colon tumors co-occur in a patient and are non-homologous, as reported in the English-language literature for the first time. Read More

Wiad Lek 2022 ;75(4 pt 2):1039-1042

BOGOMOLETS NATIONAL MEDICAL UNIVERSITY, KYIV, UKRAINE.

The given paper describes a case of treating adenocarcinoma of the papilla of Vater diagnosed as the cause after an episode of acute pancreatitis. The etiology of aсute pancreatitis was considered idiopathic until the onset of complaints caused by tumor growth. The volume of radical surgery has changed intraoperatively due to the detection of infected limited necrotic clusters, didn't diagnosed both laboratory and instrumentally. Read More

Z Gastroenterol 2022 May 11;60(5):761-778. Epub 2022 May 11.

Division of Gastroenterology, Kantonsspital Uri, Altdorf, Switzerland.

Background: The success of colorectal cancer (CRC) screening depends mainly on screening quality, patient adherence to surveillance, and costs. Consequently, it is essential to assess the performance over time.

Methods: In 2000, a closed cohort study on CRC screening in individuals aged 50 to 80 was initiated in Uri, Switzerland. Read More

Z Gastroenterol 2022 May 9. Epub 2022 May 9.

Klinik für Innere Medizin, Standort Marienkrankenhaus, GFO Kliniken Rhein-Berg, Bergisch Gladbach, Germany.

In Germany, colonoscopy was introduced as a screening instrument about 20 years ago. Ten years after an adenoma-negative index endoscopy, a second screening colonoscopy can be performed in younger persons, but this approach is based on limited evidence. We therefore prospectively analyzed the diagnostic yield of second screening colonoscopies in clinical routine. Read More

Diagnostics (Basel) 2022 Mar 23;12(4). Epub 2022 Mar 23.

1st Surgery Department, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.

We present the case of a 71-year-old male who suffered an episode of acute renal failure caused by the uncommon association of two different diseases ( infection and McKittrick-Wheelock syndrome). He presented with hypovolemic shock, severe hypokalemia, hyponatremia, metabolic acidosis and acute renal failure; consequences of secretory diarrhea caused by a giant rectal tumor revealed from colonoscopy. The biopsy results revealed tubulo-villous adenoma with low/high grade dysplasia. Read More

Endoscopy 2022 Apr 11. Epub 2022 Apr 11.

Cancer Screening and Prevention Research Group (CSPRG), Department of Surgery and Cancer, Imperial College London, London, United Kingdom.

Background: Longer post-polypectomy surveillance intervals are associated with increased colorectal neoplasia detection at surveillance in some studies. We investigated this association to inform optimal surveillance intervals.

Methods: Patients who underwent colonoscopy and post-polypectomy surveillance at 17 UK hospitals were classified as low/high risk by baseline findings. Read More

Eur J Case Rep Intern Med 2022 24;9(3):003231. Epub 2022 Mar 24.

Internal Medicine Department, Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal.

The authors present the case of a 79-year-old woman who presented with chronic secretory diarrhoea and severe electrolyte imbalance. A large rectal tubulovillous adenoma was discovered, leading to surgical resection of the tumour with complete resolution of the diarrhoea and electrolyte imbalance. The diagnosis of McKittrick-Wheelock syndrome was made. Read More

J Postgrad Med 2022 Apr-Jun;68(2):106-108

Department of Urology, Hospital Canselor Tuanku, Muhriz, Malaysia.

Primary villous adenoma originating from the urinary tract is an infrequent entity. We present a rare case of villous adenoma arising from a prostatic urethra with no sign of malignant transformation. Villous adenoma should be considered as one of the differential diagnoses of urethral lesions, especially if it has similar magnetic resonance imaging features as its colonic counterpart. Read More

Cancer Prev Res (Phila) 2022 Apr 4. Epub 2022 Apr 4.

Dartmouth-Hitchcock Medical Center, Lebanon, NH, United States.

Few studies compare fecal immunochemical test (FIT) and multi-target stool DNA (mt-sDNA) outcomes in practice. We compared colonoscopy yield following FIT+ or mt-sDNA+ tests to colonoscopies without preceding stool tests in the comprehensive population-based New Hampshire Colonoscopy Registry (NHCR). Outcomes were any neoplasia and an ordered outcome: adenocarcinoma, advanced neoplasia (adenoma/serrated polyp {greater than or equal to} 1 cm/villous/high-grade dysplasia), non-advanced neoplasia or normal. Read More

Clin Gastroenterol Hepatol 2022 Mar 24. Epub 2022 Mar 24.

Department of Gastroenterology, Hepatology and Clinical Oncology, Centre of Postgraduate Medical Education, Warsaw, Poland; Clinical Effectiveness Research Group, Institute of Health and Society, University of Oslo, Oslo, Norway; Department of Oncological Gastroenterology and Department of Cancer Prevention, The Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.

Background & Aims: The proportion of colonoscopies with at least one adenoma (adenoma detection rate [ADR]) is inversely associated with colorectal cancer (CRC) risk and death. The aim of this study was to examine whether such associations exist for colonoscopy quality measures other than ADR.

Methods: We used data from the Polish Colorectal Cancer Screening Program collected in 2000-2011. Read More

BMC Gastroenterol 2022 Mar 2;22(1):91. Epub 2022 Mar 2.

Department of Internal Medicine, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam, Gyeonggi-do, 463-707, South Korea.

Background: To evaluate whether the risk of metachronous high-risk colorectal neoplasm (HR-CRN) differs according to the indication for surveillance colonoscopy.

Methods: Patients who underwent polypectomy or endoscopic resection of colorectal neoplasms were enrolled and classified into three groups according to the indication for surveillance colonoscopy: advanced colorectal neoplasm (ACRN: adenoma ≥ 10 mm, adenoma with high-degree dysplasia and/or villous component), advanced serrated polyps (ASP: hyperplastic polyp or sessile serrated lesion ≥ 10 mm, traditional serrated polyp), and high-risk polyps (HRP: 3 or more adenomas or serrated polyps). The primary outcome was the development of metachronous HR-CRN, defined as ACRN, ASP, or HRP at the first follow-up colonoscopy. Read More

Pathol Oncol Res 2022 4;28:1610133. Epub 2022 Feb 4.

Interdisciplinary Gastroenterology Working Group, Semmelweis University, Budapest, Hungary.

While overwhelming majority of laparoscopic cholecystectomy specimens performed for gallstones or cholecystitis show rather typical findings, sometimes polypoid structures are also removed. These can be related to cholesterolosis or conventional adenomas, but occasionally extraordinary findings do emerge. In our case, a 67-year old lady with typical complaints of cholecystitis underwent routine laparoscopic cholecystectomy. Read More

Sci Rep 2022 02 16;12(1):2570. Epub 2022 Feb 16.

Institute of Biology and Medical Genetics, Institute of Physiology, 1st Faculty of Medicine, Charles University, Albertov 4, 128 00, Prague, Czech Republic.

A large proportion of colorectal carcinomas (CRC) evolve from colorectal adenomas. However, not all individuals with colonic adenomas have a risk of CRC substantially higher than those of the general population. The aim of the study was to determine the differences or similarities of mutation profile among low- and high-grade adenomas and in situ carcinoma with detailed follow up. Read More

Br J Cancer 2022 Jun 11;126(12):1744-1754. Epub 2022 Feb 11.

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.

Background: Colorectal cancer (CRC) screening is less effective at reducing cancer incidence in the proximal colon compared to the distal colorectum. We aimed to identify adenoma characteristics associated with proximal colon cancer (PCC).

Methods: Endoscopy and pathology data for patients with ≥1 adenoma detected at baseline colonoscopy were obtained from 17 UK hospitals between 2001 and 2010. Read More

BMC Cancer 2022 Jan 29;22(1):120. Epub 2022 Jan 29.

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, China.

Background: Endoscopic treatment methods for early colorectal cancer (ECRC) mainly depend on the size and morphology. It is unclear whether different endoscopic resection methods could achieve curative resection for ECRC confined in the mucosa. The study was designed to compare the rate of positive vertical margin (VM) of ECRC with advanced adenomas (AAs) including adenoma > 1 cm, villous adenoma, high-grade intraepithelial neoplasia/dysplasia stratified by different endoscopic resection methods. Read More

World J Gastrointest Endosc 2021 Dec;13(12):593-606

Pathology and Laboratory Medicine, Albany Medical Center, Albany, NY 12208, United

Composite intestinal adenoma-microcarcinoid (CIAM) is a rare intestinal lesion consisting of conventional adenoma and small, well differentiated carcinoid [microcarcinoid (MC)] at its base. The incidence of CIAM is 3.8% in surgically resected colorectal polyps. Read More

Rev Esp Enferm Dig 2022 04;114(4):245

Aparato Digestivo, Hospital Vital Álvarez Buylla, España.

We report the case of a 67-year-old male with a history of arterial hypertension and atrial fibrillation, who was admitted for acute renal failure (creatinine: 4.41 mg/dl) and hypotension. He also presented hyponatremia (129 mmol/L) and hypokalemia (2. Read More

Eur J Epidemiol 2022 Apr 15;37(4):413-422. Epub 2022 Jan 15.

Department of Nutrition, Harvard T.H. Chan School of Public Health, 667 Huntington Avenue, Kresge 906A, Boston, MA, 02115, USA.

How metabolome changes influence the early process of colorectal cancer (CRC) development remains unknown. We conducted a 1:2 matched nested case-control study to examine the associations of pre-diagnostic plasma metabolome (profiled using LC-MS) with risk of CRC precursors, including conventional adenomas (n = 586 vs. 1141) and serrated polyps (n = 509 vs. Read More

Khirurgiia (Mosk) 2021 (12):56-62

Ryazan State Medical University, Ryazan, Russia.

Objective: To identify risk factors of postoperative ileus (POI) in elective colorectal cancer (CRC) surgery.

Material And Methods: A non-randomized retrospective study included 220 patients who underwent elective surgery for colorectal tumors. The indication for surgery was CRC stage 0-IV in 213 (96. Read More

J Clin Med 2021 Nov 26;10(23). Epub 2021 Nov 26.

Department of Medical Biochemistry, Wroclaw Medical University, 50-368 Wroclaw, Poland.

The expression of monocyte chemotactic proteins (MCPs) in colorectal polyps and their suitability as targets for chemoprevention is unknown, although MCP expression and secretion can be modulated by non-steroidal inflammatory drugs. This study was designed to determine the expression patterns of MCP-1/, MCP-2/, and MCP-3/ at the protein (immunohistochemistry; = 62) and transcriptional levels (RTqPCR; = 173) in colorectal polyps with reference to the polyp malignancy potential. All chemokines were significantly upregulated in polyps at the protein level but downregulated at the transcriptional level by 1. Read More

PLoS One 2021 11;16(11):e0258878. Epub 2021 Nov 11.

Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

Background: Adenomas and serrated lesions represent heterogeneous sets of early precursors in the colorectum with varying malignant potential. They are often distinguished by their histopathologic differences, but little is known about potential differences in regulation of epithelial proliferation and apoptosis.

Methods: We conducted a protein expression analysis using tissue microarrays of 625 colorectal adenomas and 142 serrated lesions to determine potential differences in regulation of epithelial proliferation and apoptosis. Read More

Aliment Pharmacol Ther 2022 02 30;55(4):412-421. Epub 2021 Oct 30.

Clinical Effectiveness Research Group, Institute of Health and Society, University of Oslo, Oslo, Norway.

Background: Women and men with colorectal adenomas are at increased risk of colorectal cancer and colonoscopic surveillance is recommended. However, the long-term cancer risk remains unknown.

Aims: To investigate colorectal cancer incidence and mortality after adenoma removal in women and men METHODS: We identified all individuals who had adenomas removed in Norway from 1993 to 2007, with follow-up through 2018. Read More

J Pers Med 2021 Sep 29;11(10). Epub 2021 Sep 29.

Fondazione Bruno Kessler Research Institute, 38123 Trento, Italy.

Screening for colorectal cancer (CRC) continues to rely on colonoscopy and/or fecal occult blood testing since other (non-invasive) risk-stratification systems have not yet been implemented into European guidelines. In this study, we evaluate the potential of machine learning (ML) methods to predict advanced adenomas (AAs) in 5862 individuals participating in a screening program for colorectal cancer. Adenomas were diagnosed histologically with an AA being ≥ 1 cm in size or with high-grade dysplasia/villous features being present. Read More

Front Med (Lausanne) 2021 23;8:719768. Epub 2021 Sep 23.

Division of Gastroenterology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

As risk of colorectal neoplasm is varied even in persons with "average-risk," risk evaluation and tailored screening are needed. This study aimed to evaluate the risk factors of high-risk adenoma (HRA) in healthy individuals and determine the characteristics of advanced neoplasia (AN) among individual polyps. Asymptomatic adults who underwent the first lifetime screening colonoscopy at the Seoul National University Hospital Healthcare System Gangnam Center (SNUH GC) were recruited from 2004 to 2007 as SNUH GC Cohort and were followed for 10 years. Read More

J Med Imaging Radiat Oncol 2021 Oct 5. Epub 2021 Oct 5.

Department of Digestive Disorders, Aberdeen Royal Infirmary, Aberdeen, UK.

Introduction: The aim of this study was to determine the clinical significance of focal incidentally detected colorectal abnormalities on F- Fluoro-2-Deoxy-D-Glucose (FDG) PET-CT scans.

Methods: Retrospective audit of PET-CT scans performed at our institution between 2009 and 2014. Demographic and clinical details were retrieved from electronic patient records. Read More

Cureus 2021 Aug 24;13(8):e17421. Epub 2021 Aug 24.

General Surgery, Aventura Hospital and Medical Center, Aventura, USA.

Small bowel obstructions (SBO) are a common surgical problem accounting for up half of all emergency laparotomies in the United States. SBO in the virgin abdomen (SBO-VA) presents surgeons with a unique predicament as historical teaching has mandated operative exploration in these situations due to their association with more sinister etiologies. More recent research has demonstrated that this may not be the case, with adhesive disease comprising the majority of SBO-VA. Read More

Turk J Surg 2021 Mar 22;37(1):6-12. Epub 2021 Mar 22.

Department Colorectal Surgery, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India.

Objectives: Radical surgery for rectal tumours has high morbidity. Local excision of such tumours can be achieved without compromising oncologic safety. However tumours that are not accessible to local excision can be approached using Transanal Minimal Invasive Surgery (TAMIS). Read More