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Int J Surg Pathol 2019 Jan 31:1066896919826708. Epub 2019 Jan 31.

1 University of Pennsylvania, Philadelphia, PA, USA.

Villous adenomas arising in the bladder following augmentation cystoplasty procedures are exceedingly rare. Even rarer is their occurrence in the native bladder mucosa and the upper urinary tract. In this article, we present a unique case of multifocal recurrent villous adenoma involving native bladder mucosa of an augmented bladder, bilateral ureters, and renal pelvis, with coexistent foci of adenocarcinoma and neuroendocrine carcinoma, in a patient with history of augmentation colocystoplasty. Read More

Pathol Res Pract 2019 Jan 11. Epub 2019 Jan 11.

The Fingerland Department of Pathology, Charles University Faculty of Medicine and University Hospital Hradec Králové, Sokolská 581, Hradec Králové, 500 03, Czech Republic. Electronic address:

Background: Patients with inflammatory bowel disease (IBD) - ulcerative colitis (UC) and Crohn's disease (CD) have an elevated risk of developing colorectal carcinoma (CRC). Major risk factor in IBD patients is the continuous chronic inflammation leading to development of dysplasia and carcinoma. Nevertheless, other types of non-conventional but suspicious mucosal changes serrated change/dysplasia, NOS and villous hypermucinous change, have also been reported in IBD patients. Read More

Eur J Gastroenterol Hepatol 2019 Jan 21. Epub 2019 Jan 21.

Flinders Centre for Innovation in Cancer.

Background: The international guidelines for surveillance following the finding of a small tubular adenoma vary between no surveillance or colonoscopy at 5 or 10 years, whereas surveillance after an advanced adenoma is 3 years. Optimization of surveillance reduces the risk of colorectal cancer (CRC) with efficient use of colonoscopy resources. We assessed the risks of advanced colorectal neoplasia following a baseline finding of a small adenoma compared with advanced adenoma. Read More

J Formos Med Assoc 2019 Jan 14. Epub 2019 Jan 14.

Departments of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan. Electronic address:

Gut microbiota plays important roles in many diseases, including cancer. It may promote carcinogenesis by inducing oxidative stress, genotoxicity, host immune response disturbance, and chronic inflammation. Colorectal cancer, hepatocellular carcinoma, and gastric cancer are the major gastrointestinal tract cancers in Taiwan. Read More

BMC Gastroenterol 2019 Jan 5;19(1). Epub 2019 Jan 5.

Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, 02114, USA.

Background: The long-term natural history of microscopic colitis (MC) (collagenous colitis (CC), lymphocytic colitis (LC)), traditionally considered relapsing but non-progressive diseases, is poorly defined. Whether persistent histologic inflammation in such diseases is associated with an increased risk of colorectal neoplasia (CRN) or extracolonic cancers has not been robustly established.

Methods: This retrospective cohort included diagnosed with MC at a referral center. Read More

Curr Pharm Biotechnol 2018 12 25. Epub 2018 Dec 25.

Department of Engineering in Biomedical Systems, Faculty of Engineering, National Autonomous University of Mexico, Exterior Circuit, University City, 04510. Mexico.

Background: Colorectal cancer (CRC) is the second and third most frequent cancer in women and men, respectively; indeed, CRC is placed as the fourth world's most deadly cancer (after lung, liver, and stomach cancer). The incidence of CRC is strongly influenced by nutrition and the high fat/high carbohydrate Western-style diet. CRC is one of the most intensively studied cancer types, partly because of its high prevalence, but also because of the existence of its precursor lesions, tubular or villous adenomas, and more recently serrated adenomas. Read More

Histopathology 2019 Jan;74(1):68-76

Robert J. Tomsich Institute of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH, USA.

The classification of neoplastic precursor lesions in the urinary tract has evolved slowly with the gradual accumulation of clinicopathological data. Current nomenclature was codified most recently by the 2016 WHO classification, which is based on primary data with clinical outcome, consensus group statements and considerations of practical utility in routine diagnosis. This review discusses precursor lesions of urothelial, squamous and glandular lineage. Read More

Pathologica 2018 Sep;110(2):92-95

Department of Medical and Surgical Sciences and Advanced Technologies, G.F. Ingrassia, Azienda Ospedaliero-Universitaria "Policlinico-Vittorio Emanuele", Anatomic Pathology Section, School of Medicine, University of Catania, Italy.

Intestinal-type adenocarcinoma is a rare primary vaginal carcinoma and considerably more uncommon than metastatic lesions which represent the most frequent malignancy at this anatomic site. Among all malignant tumors, colorectal, breast and female genital tract carcinomas have the tendency to metastasize to the vagina.

As morphologic and immunohistochemical features of intestinal-type adenocarcinoma occurring primarily in the vagina are not specific, clinical and radiologic information is crucial to exclude a metastatic lesion. Read More

Wideochir Inne Tech Maloinwazyjne 2018 Dec 8;13(4):448-453. Epub 2018 Oct 8.

Department of General Surgery, Istanbul Training and Research Hospital, Istanbul, Turkey.

Introduction: Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are commonly used for the minimally invasive treatment of submucosal lesions of the gastrointestinal tract.

Aim: To evaluate the safety, efficacy, outcome and recurrence rate of EMR and ESD for mucosal and submucosal lesions in the colon and rectum.

Material And Methods: Records of 26 patients who underwent ESD and EMR for mucosal and submucosal lesions in the colon and rectum between January 2013 and March 2018 in our endoscopy unit were retrospectively reviewed. Read More

Saudi J Gastroenterol 2019 Jan-Feb;25(1):20-26

Division of Gastroenterology, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.

Background/aims: Colorectal cancer is the most common cancer in males and the third most common cancer in females. We aim to determine the polyp and adenoma prevalence in a cohort of patients who underwent opportunistic screening colonoscopies.

Patients And Methods: A retrospective cohort study was conducted using an endoscopic reporting database of individuals seen at three tertiary care hospitals (two public hospitals and one private) in Riyadh, Saudi Arabia. Read More

Cancer Epidemiol Biomarkers Prev 2019 Jan 20;28(1):91-98. Epub 2018 Nov 20.

Kaiser Permanente Washington Health Research Institute, Seattle, Washington.

Background: To reduce colorectal cancer incidence and mortality, experts recommend surveillance colonoscopy 3 years after advanced adenoma removal. Little is known about adherence to that interval.

Methods: We describe patterns of and factors associated with subsequent colonoscopy among persons with ≥3 adenomas and/or ≥1 adenoma with villous/tubulovillous histology in four U. Read More

Gastroenterology 2019 Feb 2;156(3):623-634.e3. Epub 2018 Nov 2.

Department of Gastroenterology, Veterans Affairs Medical Center, White River Junction, Vermont. Electronic address:

Background & Aims: With advances in endoscopic imaging, it is possible to differentiate adenomatous from hyperplastic diminutive (1-5 mm) polyps during endoscopy. With the optical Resect-and-Discard strategy, these polyps are then removed and discarded without histopathology assessment. However, failure to recognize adenomas (vs hyperplastic polyps), or discarding a polyp with advanced histologic features, could result in a patient being considered at low risk for metachronous advanced neoplasia, resulting in an inappropriately long surveillance interval. Read More

J Carcinog Mutagen 2018 11;9(2). Epub 2018 Sep 11.

Department of Medicine, Morehouse School of Medicine, 720 Westview Dr. SW Atlanta, GA 30310-1495, USA.

Objective: Colorectal cancer (CRC) develops from precancerous adenomatous polyps to malignant lesions of adenocarcinoma. Elucidating inhibition mechanisms for this route in patients with a risk of developing CRC is highly important for a potential diagnostic or prognostic marker. Differential expression of nuclear-encoded cytochrome c oxidase subunit 4 (COXIV) seems to contribute to a more unregulated respiration due to loss of ATP inhibition. Read More

BMJ Case Rep 2018 Nov 1;2018. Epub 2018 Nov 1.

Department of Paediatric Surgery, Christian Medical College and Hospital Vellore, Vellore, Tamil Nadu, India.

A 5-year-old boy with metachromatic leukodystrophy, debilitated by spastic quadriparesis presented to us with massive ascites and respiratory distress. A subtotal cholecystectomy was performed on him from another centre for a gall bladder mass a year before he came to us. Imaging revealed a polypoidal frond-like mass arising from the gall bladder fossa which was supplied by a hypertrophied branch of the right hepatic artery. Read More

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Oct;21(10):1161-1166

Endoscopy Center, The Affiliated Wuxi Second People's hospital of Nanjing Medical University, Jiangsu 214002, China.Email:

Objective: To analyze the risk factors of carcinogenesis of large colorectal polyps (diameter ≥ 10 mm) found by colonoscopy.

Methods: Clinicopathological and follow-up data of 418 consecutive patients who were diagnosed as colorectal polyps with diameter≥10 mm by colonoscopy at two endoscopy centers of the Affiliated Wuxi Second People's Hospital, Nanjing Medical University (n=207) and Zhongshan Hospital, Fudan University (n=211) from January 2015 to December 2016 were retrospectively collected. High-grade intraepithelial neoplasia and cancer were defined as malignancy in this study. Read More

In Vivo 2018 Nov-Dec;32(6):1473-1475

Gastrointestinal and Liver Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital Stockholm, Stockholm, Sweden

Background: The finding was recently reported of clusters of colonic crypts lined with indigenous normal epithelium displaying irregular shapes underneath the adenomatous glands of conventional (tubular or villous) adenomas. These abnormal crypts were named non-dysplastic corrupted colonic crypts (NDCs). This study explored the characteristics of cell proliferation in NDCs present in a cohort of conventional adenomas. Read More

Ann R Coll Surg Engl 2018 Oct 16:1-7. Epub 2018 Oct 16.

North Bristol NHS Trust , UK.

Introduction: McKittrick-Wheelock syndrome describes the condition of extreme electrolyte and fluid depletion caused by large distal colorectal tumours, usually the benign villous adenoma. Patients generally present critically unwell with severe hyponatraemia, hypokalaemia and/or acute kidney injury.

Methods: A structured literature review was undertaken to discover what is known about this condition, which is almost universally described as rare. Read More

Rev Esp Enferm Dig 2018 Oct;110(10):678-679

Hospital Universitario Central de Asturias (HUCA).

We present the case of a patient with obstructive jaundice due to a polylobulated lesion at the middle common bile duct that is identified as a villous adenoma of the main bile duct. This entity is infrequent with few references in the bibliography. It is a benign pathology but with risk of malignancy, so the diagnosis and resection is essential for adequate treatment. Read More

Am J Med Sci 2018 Aug 2;356(2):141-146. Epub 2018 May 2.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Republic of Korea.

Background: Studies on the association of chronic hepatitis B virus (HBV) infection with colonic neoplasm are rare. We aimed to investigate the association between chronic HBV infection and the development of colonic adenoma.

Materials And Methods: One hundred thirty-three patients with chronic HBV infection who underwent colonoscopic examination, were enrolled. Read More

Microb Pathog 2018 Nov 22;124:244-249. Epub 2018 Aug 22.

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Background: Colon cancer (CRC) is a heterogeneous disorder, arising from precursors-adenoma and serrated polyp. Previous studies have demonstrated the relationship between the human gut microbiota and CRC; however, its correlation to the different early precursors of CRC is not properly understood. Here, we studied the relationship between targeted gut bacteria and different colorectal polyp types, location, size and grade of dysplasia. Read More

Int J Colorectal Dis 2018 Dec 22;33(12):1695-1701. Epub 2018 Aug 22.

Department of Colorectal Surgery, Beaujon Hospital, Assistance Publique-Hôpitaux de Paris, Université Paris VII, 100 Boulevard du Général Leclerc, 92110, Clichy, France.

Purpose: Very few data are available about the clinical relevance of magnetic resonance (MR) imaging in preoperative evaluation of rectal villous adenoma. The aim is to evaluate the impact of MR imaging for the surgical management of rectal villous adenoma treated by transanal endoscopic microsurgery (TEM).

Methods: All patients with histologically proven rectal villous tumours operated by TEM who had a preoperative MR imaging between 2009 and 2017 were retrospectively reviewed. Read More

Gastroenterology 2018 11 29;155(5):1410-1415. Epub 2018 Jul 29.

Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, the Netherlands. Electronic address:

Background & Aims: It is important to identify individuals with Lynch syndrome because surveillance programs can reduce their morbidity and mortality from colorectal cancer (CRC). We assessed the diagnostic yield of immunohistochemistry to detect Lynch syndrome in patients with advanced and multiple adenomas within our national CRC screening program.

Methods: We performed a prospective study of all participants (n = 1101; 55% male; median age, 66 years; interquartile range, 61-70 years) referred to the Erasmus MC in The Netherlands after a positive result from a fecal immunohistochemical test, from December 2013 to December 2016. Read More

Radiographics 2018 Sep-Oct;38(5):1370-1384. Epub 2018 Jul 30.

From the Department of Radiology, University of Wisconsin School of Medicine and Public Health, E3/311 Clinical Sciences Center, 600 Highland Ave, Madison, WI 53792 (M.G.L.); Department of Radiology, Mayo Clinic Arizona, Phoenix, Ariz (C.O.M.); Department of Diagnostic and Interventional Imaging, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, Tex (R.J.J.); Department of Radiology, University of Missouri Healthcare, Columbia, Mo (A.H.G.); Department of Radiology, Health Sciences Center, University of Utah, Salt Lake City, Utah (A.S.); and Department of Radiology, University of Texas MD Anderson Cancer Center, Houston, Tex (K.M.E.).

Villous lesions are advanced adenomas that manifest most commonly in the colon; however, they can develop throughout the gastrointestinal tract. The duodenum is the most common small-bowel site of these lesions. Although in most cases these are isolated lesions that occur sporadically, patients with certain specific colorectal cancer syndromes, including familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer, may develop multiple advanced adenomas. Read More

J Clin Gastroenterol 2018 Jul 20. Epub 2018 Jul 20.

Departments of Medicine, Division of Gastroenterology.

Goals: We set out to determine whether variation from this 3-year follow-up interval was associated with the finding of subsequent high-risk adenoma (HRA).

Background: HRAs include the following: (1) an adenoma measuring ≥10 mm, (2) ≥3 adenomas found during a single procedure, and (3) an adenoma with high-grade dysplasia or villous architecture. The current Multi-Society Task Force guideline for timing of surveillance colonoscopy after removal of a HRA is 3 years. Read More

Histopathology 2018 Dec 9;73(6):1023-1029. Epub 2018 Oct 9.

Envoi Specialist Pathologists, Brisbane, Queensland, Australia.

Aims: Traditional serrated adenoma (TSA) is the least common subtype of serrated colorectal polyp. Large protuberant lesions are easily recognised; however, the origins of TSAs are not known, and early forms have not been described. Some large TSAs present with a flat 'shoulder' component surrounding the central protuberant component. Read More

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Jun;21(6):678-684

Department of Colorectal Surgery, Ningbo No.2 Hospital, Ningbo 315010, China.

Objective: To determine the detection rate and distribution characteristics of colorectal adenomas in Ningbo area of China, and to identify the risk factors for colorectal adenoma, in order to provide reference for colorectal cancer screening.

Methods: A cross-sectional study was performed among 8660 subjects undergoing colonoscopy in the Ningbo No.2 Hospital between January and December 2016, using a questionnaire, including demographic data (age, gender, height and weight), history of diseases (diabetes, hypertension, hyperlipidemia, and family history of malignant neoplasm), lifestyle (smoking, alcohol, dietary bias on red meat, dietary bias on fruit and vegetables, dietary frequency of pickled food and physical activities), and intestinal early warning symptoms. Read More

World J Gastroenterol 2018 Jun;24(24):2617-2627

Department of Gastroenterology Tel Aviv Medical Center, Tel Aviv 6423906, Israel.

Aim: To evaluate the association between the Mediterranean diet (MD) pattern and its components, and advanced colorectal polyps (adenoma and serrated adenoma).

Methods: A case-control study among patients undergoing screening, diagnostic or surveillance colonoscopies during 2010-2015 at the Tel-Aviv Medical Center, Gastroenterology Department. Cases with advanced polyps were defined as: Advanced adenoma [> 10 mm, with features of high grade dysplasia (HGD) or villous histology], advanced serrated adenoma (> 10 mm or with dysplasia) or multiple (≥ 3) non-advanced adenomas or serrated adenomas. Read More

Rare Tumors 2018 5;10:2036361318779514. Epub 2018 Jun 5.

Queen Elizabeth Hospital, Lewisham and Greenwich NHS Trust, London, UK.

Villous adenoma is a rare pathology seen in the urinary tract; it is mostly found in the large bowel. When encountered in the urinary tract, it mainly originates from intestinal segments of urinary reconstruction. Villous adenoma is commonly seen in patients more than 50 years and has a male predominance. Read More

Tech Coloproctol 2018 05 1;22(5):379-381. Epub 2018 Jun 1.

Department of Surgery and Transplantation, University Hospital Zürich, Raemistrasse 100, 8091, Zurich, Switzerland.

Ann Ital Chir 2018 ;89:177-181

Background: One of the minimally invasive methods used in the surgical treatment of large-based polypoid lesions located in the rectum is transanal minimally invasive surgery (TAMIS). This method, which relieves patients from the severe morbidities of invasive surgical procedures, is performed in both malign (T1-T2) and benign lesions. Difficulty of suturation after TAMIS emerges as the most important factor to prolong the procedure. Read More

JAMA 2018 05;319(19):2021-2031

Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.

Importance: Individuals with adenomatous polyps are advised to undergo repeated colonoscopy surveillance to prevent subsequent colorectal cancer (CRC), but the relationship between adenomas at colonoscopy and long-term CRC incidence is unclear.

Objective: To compare long-term CRC incidence by colonoscopy adenoma findings.

Design, Setting, And Participants: Multicenter, prospective cohort study of participants in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer randomized clinical trial of flexible sigmoidoscopy (FSG) beginning in 1993 with follow-up for CRC incidence to 2013 across the United States. Read More

Gut Liver 2018 09;12(5):508-515

Department of Laboratory Medicine, Eulji General Hospital, Eulji University School of Medicine, Seoul, Korea.

Background/aims: methylation was previously reported as a sensitive serologic biomarker for the early detection of colorectal cancer (CRC). The purpose of this study was to investigate whether methylation is detectable in precancerous lesions and to determine the feasibility of using methylation for the detection of CRC and precancerous lesions in bowel lavage fluid (BLF).

Methods: A total of 190 BLF samples were collected from the rectum at the beginning of colonoscopy from patients with colorectal neoplasm and healthy normal individuals. Read More

Cancer Prev Res (Phila) 2018 Jul 23;11(7):403-412. Epub 2018 Apr 23.

Department of Pathology, Netherlands Cancer Institute, Amsterdam, the Netherlands.

About 5% of colorectal adenomas are estimated to progress to colorectal cancer. However, it is important to identify which adenomas actually carry a high risk of progression, because these serve as intermediate endpoints, for example, in screening programs. In clinical practice, adenomas with a size of ≥10 mm, villous component and/or high-grade dysplasia, called advanced adenomas, are considered high risk, although solid evidence for this classification is lacking. Read More

Cancer Med 2018 May 23;7(5):2109-2120. Epub 2018 Mar 23.

Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, 60208, USA.

Prior to the development of a localized cancerous tumor, diffuse molecular, and structural alterations occur throughout an organ due to genetic, environmental, and lifestyle factors. This process is known as field carcinogenesis. In this study, we used partial wave spectroscopic (PWS) microscopy to explore the progression of field carcinogenesis by measuring samples collected from 190 patients with a range of colonic history (no history, low-risk history, and high-risk history) and current colon health (healthy, nondiminutive adenomas (NDA; ≥5 mm and <10 mm), and advanced adenoma [AA; ≥10 mm, HGD, or >25% villous features]). Read More

Clin Colorectal Cancer 2018 06 20;17(2):e363-e367. Epub 2018 Feb 20.

Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI.

Background: Incidence and mortality from colorectal cancer (CRC) are higher among African Americans where CRC screening rates lag behind non-Hispanic whites. The purpose of this investigation was to evaluate CT colonography (CTC) performance and outcome measures in an African-American cohort.

Materials And Methods: This study is an institutional review board-approved and Health Insurance Portability and Accountability Act-compliant study. Read More

J Dig Dis 2018 Apr 15;19(4):235-241. Epub 2018 Apr 15.

Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin Institute of Digestive Disease, Tianjin, China.

Objective: A growing body of evidence indicates that patients with colorectal serrated lesions, especially advanced serrated lesions (ASLs), are at risk of subsequent malignancy. This study aimed to analyze the clinicopathological features of ASLs and the association between ASLs and synchronous advanced colorectal neoplasia (sACN) in a single center of China.

Methods: A retrospective cross-sectional study of consecutive symptomatic patients and healthy individuals who underwent colonoscopy between January 2010 and March 2016 was performed. Read More

Gan To Kagaku Ryoho 2018 Feb;45(2):300-302

Dept. of Surgery, Fujisaki Hospital.

We present here a case of transduodenal ampullectomy for an ampullary neoplasm coexisting with gastric and colon cancer. The patient was a 72-year-old man who was referred to our hospital with a positive fecal blood test. Colonoscopy revealed advanced cancer in the descending colon. Read More

Arkh Patol 2018 ;80(1):27-36

Lomonosov Moscow State University, Moscow, Russia; Russian Medical Academy of Postgraduate Education Ministry of Health of Russia, Moscow, Russia.

Aim: the evaluation of Ki-67 and CD44 expression in the 'serrated' polyps of the colon and comparison them with adenocarcinomas and tubular and tubule-villous adenomas of the colon.

Material And Methods: The study is including 49 'serrated' polyps, 34 tubular (AT) and tubulo-villous (ATV) adenomas and 32 adenocarcinomas of the colon. Antibodies CD44 and Ki-67 were used as immunohistochemical markers in this study. Read More

APMIS 2018 Mar 4;126(3):191-200. Epub 2018 Feb 4.

Department of Urology, PGIMER, Chandigarh, India.

Villous adenoma and urothelial carcinoma with villoglandular differentiation (UCVGD) are rare urothelial tumours showing villous morphology, the former being a preneoplastic entity and the latter being a malignant one. The detailed immunohistochemistry of these entities is previously not described in the literature. Moreover, a limited biopsy sample of UCVGD or a villous adenoma with or without adenocarcinoma may be difficult to distinguish on the basis of the histomorphology alone. Read More

Anticancer Res 2018 02;38(2):919-921

Division of Pathology, Geneva University Hospital, Geneva, Switzerland.

Background: In ulcerative colitis (UC), the majority of colorectal carcinomas (CRC) arise in the vast colorectal mucosal domain built with mucus-producing goblet cells and columnar cells. Conversely, CRC in UC rarely evolve in the tiny, spotty gut-associated lymphoid tissue (GALT) mucosal domain. Here we review the four reported cases of colonic carcinoma developing in GALT mucosa in UC, searching for possible precursor lesions connected with the evolution of these tumours. Read More

Colorectal Dis 2018 04;20(4):357

Department of General and Digestive Surgery, Reina Sofia University Hospital, Cordoba, Spain.

J Gastrointest Cancer 2018 Jun;49(2):172-180

Department of Pathology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

Purpose: Some epidemiological studies have shown an association between opium consumption and the incidence of gastrointestinal (GI) cancer. The present study was designed to investigate the effects of opium on the initiation of GI cancer in rats.

Methods: Forty-five rats were randomly divided into three groups; each received different treatment for 40 weeks. Read More

Urol Case Rep 2018 Jan 16;16:25-28. Epub 2017 Oct 16.

Department of Urology, Geisinger Medical Center, Danville, PA, USA.

Korean J Intern Med 2018 Nov 5;33(6):1084-1092. Epub 2018 Jan 5.

Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background/aims: There has been no evidence for the necessity of endoscopy in asymptomatic young men with iron deficiency anemia (IDA). To determine whether endoscopy should be recommended in asymptomatic young men with IDA, we compared the prevalence of gastrointestinal (GI) lesions between young men (< 50 years) with IDA and those without IDA.

Methods: We conducted a case-control study on asymptomatic young men aged < 50 years who underwent both esophagogastroduodenoscopy (EGD) and colonoscopy as part of a health checkup between 2010 and 2014. Read More

Colorectal Dis 2018 Jun;20(6):502-508

Royal Wolverhampton NHS Foundation Trust, Wolverhampton, UK.

Aim: In the UK Bowel Scope Screening Programme (BSSP), patients progress to colonoscopy based on high-risk features on flexible sigmoidoscopy (FS). We aim to assess the practice of colonoscopy conversion and predictors of detection of additional adenomas on colonoscopy.

Method: The Bowel Cancer Screening database was interrogated and collated with endoscopic and histological findings from patients undergoing colonoscopy following FS between August 2013 and August 2016. Read More

Anticancer Res 2017 12;37(12):6667-6670

Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden

Background: Recent studies have disclosed novel histological phenotypes of colon tumours in carcinogen-treated rats. The aim of this study was to update the current histological classification of colonic neoplasias in Sprague-Dawley (SD) rats.

Materials And Methods: Archival sections from 398 SD rats having 408 neoplasias in previous experiments were re-evaluated. Read More

Rev Med Chil 2017 Jul;145(7):950-953

Departamento de Medicina, Escuela de Medicina, Universidad de Valparaíso, Viña del Mar, Chile.

McKittrick-Wheelock syndrome is caused by chronic water and electrolyte hypersecretion from an intestinal tumor, usually a villous adenoma, located in the rectum or sigmoid. Patients often have dehydration, hypovolemic shock and kidney failure associated with hypokalemia, hyponatremia, hypochloremia and metabolic acidosis. We report a 62-year-old male, suffering chronic diarrhea for eight years who was admitted after a syncope. Read More

J Clin Med Res 2017 Dec 6;9(12):1022-1025. Epub 2017 Nov 6.

Unit of Pathology, Department of Oncology and Advanced Technologies, IRCCS-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.

Sprue-like enteropathy associated with olmesartan medoxomil use has been recently reported. Its clinical manifestations include diarrhea, weight loss and malabsorption. Duodenal biopsies show villous atrophy (VA) with or without intraepithelial lymphocytosis and inflammation of the lamina propria. Read More

Oncotarget 2017 Sep 21;8(42):72352-72362. Epub 2017 Aug 21.

Department of Laboratory Medicine, Chang Gung Memorial Hospital at LinKou, Taoyuan, Taiwan.

Colorectal cancer (CRC) develops from accumulated mutations. However, which gene determines the malignant transformation from adenoma to carcinoma is still uncertain. Fifty-three formalin fixed paraffin-embedded polyps that had pathological findings from patients with hyperplasia, adenomatous, and tubular adenoma < 1 cm (non-neoplasia polyps, NNP, = 27) or tubular adenoma ≥ 1 cm, tubulovillous and villous adenoma (neoplastic polyps, NP, = 26) were recruited. Read More