Surface hypothermia predicts murine mortality in the intragastric Vibrio vulnificus infection model.
BMC Microbiol 2017 Jun 19;17(1):136. Epub 2017 Jun 19.
Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, 303 E. Chicago Ave, Ward 6-205, Chicago, IL, 60611, USA.
Background: The Gram-negative bacterium Vibrio vulnificus can cause severe disease in humans who consume undercooked, contaminated seafood. To study food-borne V. vulnificus disease in the laboratory, mouse virulence studies predominantly use death as the primary experimental endpoint because behaviorally based moribund status does not consistently predict lethality. Read More