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    165 results match your criteria Vibrio Vulnificus Infection

    1 OF 4

    Transcriptome analysis of the effect of polyunsaturated fatty acids against Vibrio vulnificus infection in Oreochromis niloticus.
    Fish Shellfish Immunol 2017 Mar 17;62:153-163. Epub 2017 Jan 17.
    Marine Research Station, Institute of Cellular and Organismic Biology, Academia Sinica, 23-10 Dahuen Road, Jiaushi, Ilan 262, Taiwan. Electronic address:
    Vibrio vulnificus infection causes severe economic losses in Oreochromis niloticus aquaculture by inducing pro-inflammatory cytokines, that lead to inflammation and mortality. Omega-3 fatty acids, such as Docosahexaenoic acid (DHA) and Eicosapentaenoic acid (EPA), have been reported for their anti-inflammatory and antibacterial abilities in murine and zebrafish models. However, the anti-inflammatory and antibacterial functions of DHA and EPA in commercial aquaculture organisms such as Oreochromis niloticus remain unknown. Read More

    In vitro and in vivo antibacterial activity of tigecycline against Vibrio vulnificus.
    J Microbiol Immunol Infect 2016 May 13. Epub 2016 May 13.
    Department of Medicine, Chi Mei Medical Center, Tainan, Taiwan; Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan; Department of Medicine, Chi Mei Medical Center, Liou Ying, Tainan, Taiwan. Electronic address:
    Background/purpose: The aim of this study is to investigate the role of tigecycline in Vibrio vulnificus infection.

    Methods: Eight randomly selected clinical V. vulnificus isolates were studied to obtain the minimal inhibitory concentrations (MICs) of minocycline, cefotaxime, and tigecycline, and the time-kill curves of tigecycline alone or in combination with other drugs. Read More

    Vibrio vulnificus infection and liver cirrhosis: a potentially lethal combination.
    BMJ Case Rep 2016 May 5;2016. Epub 2016 May 5.
    Reading Hospital & Medical Center, Reading, Pennsylvania, USA.
    We present a case of a 40-year-old man with decompensated alcoholic liver cirrhosis presenting with atraumatic cellulitis of one extremity and severe sepsis that rapidly progressed to compartment syndrome despite broad-spectrum antibiotics. Local cultures following debridement revealed Vibrio vulnificus, and subsequent history revealed consumption of raw oysters 48 h before presentation. Our case points out the unique susceptibility of those with cirrhosis and elevated iron saturation to Vibrio septicaemia, as well as the rapidity and severity of the disease progression. Read More

    Successful Treatment of a Case of Necrotizing Fasciitis due to Vibrio vulnificus in a Cold Climate in Japan.
    Intern Med 2016 15;55(8):1007-10. Epub 2016 Apr 15.
    Department of General Medicine, Aomori Prefectural Central Hospital, Japan.
    Vibrio vulnificus infection often occurs in warm regions, frequently leading to necrotizing fasciitis, sepsis, and death. We herein report a rare case presenting in a cold climate region in northern Japan, Aomori district, of a V. vulnificus infection complicated by necrotizing fasciitis and septic shock. Read More

    [When should notification of an infectious disease be mandatory? A decision aid to determine whether mandatory notification is justified].
    Ned Tijdschr Geneeskd 2016 ;160:A9768
    Rijksinstituut voor Volksgezondheid en Milieu, Centrum Infectieziektebestrijding, Bilthoven.
    In the Netherlands, all physicians are required to report cases of certain infectious diseases to the public health services, to allow appropriate control measures. In recent years, various requests have been submitted to add certain infectious diseases to the list of notifiable diseases. In order to decide whether such a request should be granted, we developed a structured decision aid based on a range of existing criteria for mandatory notification, applied in the Netherlands and other countries. Read More

    Distribution of Fatal Vibrio Vulnificus Necrotizing Skin and Soft-Tissue Infections: A Systematic Review and Meta-Analysis.
    Medicine (Baltimore) 2016 Feb;95(5):e2627
    From the College of Medicine, Chang Gung University, Taoyuan (K-CH, H-HW, T-SC, T-WH, MSL); Department of Orthopaedic Surgery (K-CH, T-YY, T-WH); Department of Diagnostic Radiology (H-HW); Department of Gastroenterology, Chang Gung Memorial Hospital, Chaiyi (T-SC); and Department of Orthopaedic Surgery, Chang Gung Memorial Hospital, Kaohsiung, Taiwan (MSL).
    Vibrio vulnificus necrotizing skin and soft tissue infections (VNSSTIs), which have increased significantly over the past few decades, are still highly lethal and disabling diseases despite advancing antibiotic and infection control practices. We, therefore, examined the spatiotemporal distribution of worldwide reported episodes and associated mortality rates of VNSSTIs between 1966 and 2014. The PubMed and Cochrane Library databases were systematically searched for observational studies on patients with VNSSTIs. Read More

    Septic arthritis and subsequent fatal septic shock caused by Vibrio vulnificus infection.
    BMJ Case Rep 2015 Nov 24;2015. Epub 2015 Nov 24.
    Department of Clinical Microbiology, University Hospital of Odense, Svendborg Hospital, Odense, Denmark.
    Vibrio vulnificus is a rare but potential fatal bacterium that can cause severe infections. Wound infections, primary sepsis and gastroenteritis are the most common clinical features. Septic arthritis caused by V. Read More

    Transgenic expression of omega-3 PUFA synthesis genes improves zebrafish survival during Vibrio vulnificus infection.
    J Biomed Sci 2015 Nov 17;22:103. Epub 2015 Nov 17.
    Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, 115, Taiwan.
    Background: Highly desaturated n-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are synthesized by desaturases and elongase. They exert hepatoprotective effects to prevent alcoholic fatty liver syndrome or cholestatic liver injury. However, it is unclear how n-3 PUFAs improve immune function in liver. Read More

    To notify or not to notify: decision aid for policy makers on whether to make an infectious disease mandatorily notifiable.
    Euro Surveill 2015 ;20(34):30003
    National Institute for Public Health and the Environment, Bilthoven, the Netherlands.
    Mandatory notification can be a useful tool to support infectious disease prevention and control. Guidelines are needed to help policymakers decide whether mandatory notification of an infectious disease is appropriate. We developed a decision aid, based on a range of criteria previously used in the Netherlands or in other regions to help decide whether to make a disease notifiable. Read More

    Correlations between Clinical Features and Mortality in Patients with Vibrio vulnificus Infection.
    PLoS One 2015 14;10(8):e0136019. Epub 2015 Aug 14.
    State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310003, China.
    Vibrio vulnificus is a common gram-negative bacterium, which might cause morbidity and mortality in patients following consumption of seafood or exposure to seawater in Southeast China. We retrospectively analyzed clinical data of patients with laboratory confirmed V. vulnificus infection. Read More

    Analysis of Vibrio vulnificus Infection Risk When Consuming Depurated Raw Oysters.
    J Food Prot 2015 Jun;78(6):1113-8
    Food Process Engineering Group, Department of Food Science and Technology, Oregon State University, Corvallis, Oregon 97331, USA.
    A beta Poisson dose-response model for Vibrio vulnificus food poisoning cases leading to septicemia was used to evaluate the effect of depuration at 15 °C on the estimated health risk associated with raw oyster consumption. Statistical variability sources included V. vulnificus level at harvest, time and temperature during harvest and transportation to processing plants, decimal reductions (SV) observed during experimental circulation depuration treatments, refrigerated storage time before consumption, oyster size, and number of oysters per consumption event. Read More

    Identification of Novel Inflammatory Cytokines and Contribution of Keratinocyte-Derived Chemokine to Inflammation in Response to Vibrio vulnificus Infection in Mice.
    Inflammation 2015 Oct;38(5):1864-73
    Department of Laboratory Medicine, General Hospital of Ji'nan Military Region of PLA, Ji'nan, 250031, Shandong Province, People's Republic of China.
    Currently, only tumor necrosis factor alpha (TNF-α) and interleukin family cytokines have been found to be elicited in Vibrio vulnificus (V. vulnificus)-infected animal models and humans. However, multiple other cytokines are also involved in the immune and inflammatory responses to foreign microorganism infection. Read More

    pH level as a marker for predicting death among patients with Vibrio vulnificus infection, South Korea, 2000-2011.
    Emerg Infect Dis 2015 Feb;21(2):259-64
    Vibrio vulnificus infection can progress to necrotizing fasciitis and death. To improve the likelihood of patient survival, an early prognosis of patient outcome is clinically important for emergency/trauma department doctors. To identify an accurate and simple predictor for death among V. Read More

    Zebrafish fed on recombinant Artemia expressing epinecidin-1 exhibit increased survival and altered expression of immunomodulatory genes upon Vibrio vulnificus infection.
    Fish Shellfish Immunol 2015 Jan 23;42(1):1-15. Epub 2014 Oct 23.
    Institute of Bioscience and Biotechnology, National Taiwan Ocean University, 2, Pei Ning Road, Keelung 20224, Taiwan; Marine Research Station, Institute of Cellular and Organismic Biology, Academia Sinica, 23-10 Dahuen Road, Jiaushi, Ilan 262, Taiwan. Electronic address:
    Artemia has been used extensively in aquaculture as fodder for larval fish, shrimp, and shellfish. Epinecidin-1, an antimicrobial peptide, was isolated from grouper (Epinephelus coioides) in 2005. Epinecidin-1 has been previously reported to possess antimicrobial activity against several Gram-positive and Gram-negative bacterial species, including Staphylococcus coagulase, Pseudomonas aeruginosa, Streptococcus pyogenes, and Vibrio vulnificus. Read More

    Monoclonal antibodies against Vibrio vulnificus RtxA1 elicit protective immunity through distinct mechanisms.
    Infect Immun 2014 Nov 25;82(11):4813-23. Epub 2014 Aug 25.
    Department of Microbiology and Immunology, Chonbuk National University Medical School, Jeonju, Jeonbuk, South Korea Institute for Medical Science, Chonbuk National University Medical School, Jeonju, Jeonbuk, South Korea
    Vibrio vulnificus causes rapidly progressing septicemia with an extremely high mortality rate (≥50%), even with aggressive antibiotic treatment. The bacteria secrete multifunctional autoprocessing repeats-in-toxin (MARTX) toxins, which are involved in the pathogenesis of Gram-negative Vibrio species. Recently, we reported that immunization with the C-terminal region of V. Read More

    Liposome-encapsulated cinnamaldehyde enhances zebrafish (Danio rerio) immunity and survival when challenged with Vibrio vulnificus and Streptococcus agalactiae.
    Fish Shellfish Immunol 2014 May 12;38(1):15-24. Epub 2014 Mar 12.
    Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 912, Taiwan. Electronic address:
    Cinnamaldehyde, which is extracted from cinnamon, is a natural compound with activity against bacteria and a modulatory immune function. However, the antibacterial activity and immunostimulation of cinnamaldehyde in fish has not been well investigated due to the compound's poor water solubility. Thus, liposome-encapsulated cinnamaldehyde (LEC) was used to evaluate the effects of cinnamaldehyde on in vitro antibacterial activity against aquatic pathogens and in vivo immunity and protection parameters against Vibrio vulnificus and Streptococcus agalactiae. Read More

    Dietary supplementation of Bacillus subtilis and fructooligosaccharide enhance the growth, non-specific immunity of juvenile ovate pompano, Trachinotus ovatus and its disease resistance against Vibrio vulnificus.
    Fish Shellfish Immunol 2014 May 12;38(1):7-14. Epub 2014 Mar 12.
    Key Laboratory of Marine Biotechnology of Guangxi, Guangxi Institute of Oceanology, 92 Changqing Road East, Beihai, Guangxi 536000, PR China.
    A feeding trial was conducted to investigate the effects of dietary administration of probiotic Bacillus subtilis and prebiotic fructooligosaccharide (FOS) on growth performance, immune responses and disease resistance of juvenile ovate pompano, Trachinotus ovatus. One thousand six hundred and twenty individuals (initial body weight: 10.32 ± 0. Read More

    Prognostic factor of mortality and its clinical implications in patients with necrotizing fasciitis caused by Vibrio vulnificus.
    Eur J Clin Microbiol Infect Dis 2014 Jun 14;33(6):1011-8. Epub 2014 Jan 14.
    Division of Plastic and Reconstructive Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138 Sheng-Li Road, Tainan, 704, Taiwan.
    In Taiwan, the aquatic environment and endemic hepatitis contribute to the high susceptibility of Vibrio vulnificus infection. A multidisciplinary treatment protocol for necrotizing fasciitis caused by V. vulnificus was developed in our institute, namely, ceftriaxone or ceftazidime combined with doxycycline or minocycline followed by an emergency fasciotomy and intensive care unit admission. Read More

    Protection against Vibrio vulnificus infection by active and passive immunization with the C-terminal region of the RtxA1/MARTXVv protein.
    Vaccine 2014 Jan 17;32(2):271-6. Epub 2013 Nov 17.
    Department of Microbiology and Immunology, Chonbuk National University Medical School, Jeonju, Jeonbuk 561-756, Republic of Korea; Institute for Medical Science, Chonbuk National University Medical School, Jeonju, Jeonbuk 561-756, Republic of Korea. Electronic address:
    Vibrio vulnificus is a foodborne pathogen that is prevalent in coastal waters worldwide. Infection with V. vulnificus causes septicemia with fatality rates exceeding 50% even with aggressive antibiotic therapy. Read More

    A fish-stunning wound infection with acute cardiac injury.
    Am J Emerg Med 2014 Mar 2;32(3):289.e1-2. Epub 2013 Oct 2.
    Department of Intensive Care Medicine, Chi Mei Medical Center, Tainan, Taiwan; Department of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:
    Vibrio vulnificus typically causes septicemia and necrotic wound infection. Among V vulnificus–related complications, acute nonthrombotic myocardial damage has not been reported. The most effective antibiotic treatment of V vulnificus infection includes combination of a third-generation cephalosporin and a tetracycline or its analogue. Read More

    Contribution of six flagellin genes to the flagellum biogenesis of Vibrio vulnificus and in vivo invasion.
    Infect Immun 2014 Jan 7;82(1):29-42. Epub 2013 Oct 7.
    Clinical Vaccine R&D Center, Chonnam National University Hwasun Hospital, Jeonnam, South Korea.
    Vibrio vulnificus is a halophilic pathogenic bacterium that is motile due to the presence of a single polar flagellum. V. vulnificus possesses a total of six flagellin genes organized into two loci (flaFBA and flaCDE). Read More

    Identification of 62-kDa protein as an immunogenic antigen of Vibrio vulnificus for humans.
    Fukuoka Igaku Zasshi 2013 Jul;104(7):222-33
    Department of Anesthesiology and Critical Care Medicine, Saga University Faculty of Medicine, Japan.
    Vibrio vulnificus infection can cause necrotizing fasciitis and sepsis and can develop within a few days despite intensive care. The mortality rate is up to 60% in vulnerable people. Most patients infected with this microbe have chronic liver disease, especially liver cirrhosis or cancer, as an underlying disease. Read More

    Electrotransfer of the epinecidin-1 gene into skeletal muscle enhances the antibacterial and immunomodulatory functions of a marine fish, grouper (Epinephelus coioides).
    Fish Shellfish Immunol 2013 Nov 23;35(5):1359-68. Epub 2013 Aug 23.
    Marine Research Station, Institute of Cellular and Organismic Biology, Academia Sinica, 23-10 Dahuen Road, Jiaushi, Ilan 262, Taiwan.
    Electrotransfer of plasmid DNA into skeletal muscle is a common non-viral delivery system for the study of gene function and for gene therapy. However, the effects of epinecidin-1 (epi) on bacterial growth and immune system modulation following its electrotransfer into the muscle of grouper (Epinephelus coioides), a marine fish species, have not been addressed. In this study, pCMV-gfp-epi plasmid was electroporated into grouper muscle, and its effect on subsequent infection with Vibrio vulnificus was examined. Read More

    Impact of 2003 state regulation on raw oyster-associated Vibrio vulnificus illnesses and deaths, California, USA.
    Emerg Infect Dis 2013 Aug;19(8):1276-80
    Department of Public Health, Richmond and Sacramento, California 94804, USA.
    US vibriosis rates have increased since 1996, and many Vibrio vulnificus infections are fatal. In April 2003, California implemented a regulation restricting the sale of raw oysters harvested from the Gulf of Mexico during April 1-October 31, unless they were processed to reduce V. vulnificus to nondetectable levels. Read More

    Seasonality, clinical types and prognostic factors of Vibrio vulnificus infection.
    J Infect Dev Ctries 2013 Jul 15;7(7):533-40. Epub 2013 Jul 15.
    Institute of Medicine and School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
    Introduction: Vibrio vulnificus infection, an uncommon but life-threatening illness, manifests as two main types, primary septicemia and primary wound infections.  Little information regarding the seasonality of V. vulnificus infections in tropical areas and prognostic factors of primary V. Read More

    Pre-existing medical conditions associated with Vibrio vulnificus septicaemia.
    Epidemiol Infect 2014 Apr 10;142(4):878-81. Epub 2013 Jul 10.
    Division of Foodborne, Waterborne and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
    Vibrio vulnificus (Vv) can result in severe disease. Although pre-existing liver disease is a recognized risk factor for serious infection, the relative importance of other comorbidities has not been fully assessed. We analysed reports of Vv infections submitted to CDC from January 1988 to September 2006 in order to assess the role of pre-existing conditions contributing to severe outcomes. Read More

    Vibrio vulnificus infection in Southern Brazil -- case report.
    An Bras Dermatol 2013 May-Jun;88(3):424-6
    Infectology Service, Teaching Hospital, Federal University of Paraná, Curitiba, PR, Brazil.
    The genus Vibrio is a member of the family Vibrionaceae, and among their disease-causing species, Vibrio vulnificus, a lactose-positive gram-negative bacillus, is one of the most virulent pathogen of the noncholerae vibrios. We describe the case of a 39-year-old male patient, who was using immunosuppressive therapy, admitted to the hospital for liver transplantation. Twelve hours later, the patient presented high fever, myalgia, anuria and erythematous plaques on lower limbs, of rapid growth and proximal progression. Read More

    The fur-iron complex modulates expression of the quorum-sensing master regulator, SmcR, to control expression of virulence factors in Vibrio vulnificus.
    Infect Immun 2013 Aug 28;81(8):2888-98. Epub 2013 May 28.
    Department of Life Science, Sogang University, Seoul, South Korea.
    The gene vvpE, encoding the virulence factor elastase, is a member of the quorum-sensing regulon in Vibrio vulnificus and displays enhanced expression at high cell density. We observed that this gene was repressed under iron-rich conditions and that the repression was due to a Fur (ferric uptake regulator)-dependent repression of smcR, a gene encoding a quorum-sensing master regulator with similarity to luxR in Vibrio harveyi. A gel mobility shift assay and a footprinting experiment demonstrated that the Fur-iron complex binds directly to two regions upstream of smcR (-82 to -36 and -2 to +27, with respect to the transcription start site) with differing affinities. Read More

    Rapid Emergency Medicine Score as a main predictor of mortality in Vibrio vulnificus-related patients.
    Am J Emerg Med 2013 Jul 20;31(7):1037-41. Epub 2013 May 20.
    Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
    Objectives: Vibrio vulnificus causes potentially life-threatening and rapidly progressing infections. Therefore, the severity-of-illness assessment appears to be important for V vulnificus-infected patients at the time of admission. The aim of our study was to evaluate the performance of the severity-of-illness scoring model on admission in V vulnificus-infected patients. Read More

    Impact of timing of surgery on outcome of Vibrio vulnificus-related necrotizing fasciitis.
    Am J Surg 2013 Jul 12;206(1):32-9. Epub 2013 Feb 12.
    Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan.
    Background: The aim of this study was to evaluate the impact of timing of surgery on mortality risk in patients with necrotizing fasciitis (NF) caused by Vibrio vulnificus infection.

    Methods: Medical records of 121 patients (mean age, 65.2 ± 11. Read More

    Distribution of virulence markers among Vibrio vulnificus isolates of clinical and environmental origin and regional characteristics in Japan.
    PLoS One 2013 30;8(1):e55219. Epub 2013 Jan 30.
    Department of Applied Biochemistry and Food Science, Faculty of Agriculture, Saga University, Saga, Japan.
    Background: Vibrio vulnificus is an opportunistic human pathogen that is widely distributed in estuarine environments and is capable of causing necrotizing fasciitis and sepsis. In Japan, based on epidemiological research, the incidences of V. vulnificus were concentrated in Kyusyu, mainly in coastal areas of the Ariake Sea. Read More

    Accurate diagnosis and treatment of Vibrio vulnificus infection: a retrospective study of 12 cases.
    Braz J Infect Dis 2013 Jan-Feb;17(1):7-12. Epub 2013 Jan 14.
    Department of Critical Care Medicine, Saga Medical School Hospital, Saga, Japan.
    Background And Aims: Vibrio vulnificus causes an infectious disease that has extremely poor convalescence and leads to necrotic fasciitis. In this study, we sought to define the characteristic epidemiology of V. vulnificus infection and clarify its diagnosis at the global level. Read More

    The regulator HlyU, the repeat-in-toxin gene rtxA1, and their roles in the pathogenesis of Vibrio vulnificus infections.
    Microbiologyopen 2012 Dec 28;1(4):502-13. Epub 2012 Nov 28.
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon 97239, USA.
    HlyU is a master regulator that plays an essential role in the virulence of the human pathogen Vibrio vulnificus. One of the most noteworthy characteristics of HlyU regulation in this organism is its positive control of the expression of the repeat-in-toxin (RtxA1) gene, one of the most important virulence factors accounting for the fulminating and damaging nature of V. vulnificus infections. Read More

    Localization of Vibrio vulnificus infection in dendritic cells and its effects on the cytoskeleton.
    Chin Med J (Engl) 2012 Dec;125(23):4264-9
    Department of Clinical Laboratory, Second Hospital of Jiaxing, Jiaxing, Zhejiang 314000, China.
    Background: Vibrio vulnificus (Vv) is an estuarine bacterium that can cause primary septicemia as well as serious wound infections. However, little is known about the mechanisms by which Vv infects dendritic cells (DCs) and its effects on cytoskeleton. In this study, we aimed to investigate the invasion, internalization, and the organelles damage of the cultured dendritic cells (a DC 2. Read More

    The Laboratory Risk Indicator for Necrotizing Fasciitis score for discernment of necrotizing fasciitis originated from Vibrio vulnificus infections.
    J Trauma Acute Care Surg 2012 Dec;73(6):1576-82
    Institute of Medicine, School of Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.
    Background: The Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) score has been verified as a useful diagnostic tool for detecting necrotizing fasciitis (NF). Its application, however, is mainly for NF types I and II. The practical relevance of the LRINEC score for Vibro vulnificus-related skin and soft tissue infection (SSTI) was hardly ever investigated. Read More

    [Effects of three antigens extracted from Vibrio vulnificus on the immunological protection of Nibea albiflora].
    Dongwuxue Yanjiu 2012 Oct;33(5):503-9
    Zhejiang Mariculture Research Institute, Zhejiang Key Laboratory of Exploitation and Preservation of Coastal Bio-resource, Wenzhou 325005, China.
    Nibea albiflora was immunized by intraperitoneal injection with either Lipopolysaccharide (LPS) or outer membrane protein (OMP) extracted from Vibrio vulnificus or formalin killed Vibrio vulnificus (FKC). The influence of the three antigens on the immunological function of Nibea albiflora was determined at different time points following the injection by testing the agglutinating antibody titers of the serum, lysozyme activity of the serum, phagocytic activity of the blood and the relative survival percentage. The results showed that the three antigens have higher immunogenicity and antigenicity than the control group(injection with sterile saline). Read More

    A case series of Vibrio vulnificus infections in New Orleans, Louisiana.
    J La State Med Soc 2012 Jul-Aug;164(4):197-201, 203-4
    Tulane University Medical Center, New Orleans, USA.
    Objective: The objective of this study is to describe cases of V. vulnificus infection and to review the literature, emphasizing salient aspects of infection for practicing physicians.

    Methods: A retrospective review of all patients aged 5 years and older who grew V. Read More

    Oral administration of recombinant epinecidin-1 protected grouper (Epinephelus coioides) and zebrafish (Danio rerio) from Vibrio vulnificus infection and enhanced immune-related gene expressions.
    Fish Shellfish Immunol 2012 Jun 1;32(6):947-57. Epub 2012 Mar 1.
    Marine Research Station, Institute of Cellular and Organismic Biology, Academia Sinica, Jiaushi, Ilan 262, Taiwan.
    Immunostimulatory effects of the oral administration of the recombinant epinecidin-1 protein from BL21 Escherichia coli (containing the pET28a-epinecidin-1-dsRed plasmid) were studied in grouper (Epinephelus coioides) and zebrafish (Danio rerio). For this purpose, fish were fed diets for 30 days containing the recombinant epinecidin-1 protein from BL21 E. coli (containing the pET28a-epinecidin-1-dsRed plasmid) at different bacterial numbers (10(4), 10(6), 10(8), and 10(10) colony-forming units (cfu) of BL21 E. Read More

    Quantitative PCR and in vivo efficacy of antibiotics in the treatment of Vibrio vulnificus infection in a mouse model.
    Eur J Clin Microbiol Infect Dis 2012 Sep 21;31(9):2461-7. Epub 2012 Mar 21.
    Division of Infectious Diseases, Department of Internal Medicine, Chosun University School of Medicine, 588 Seosuk-dong, Dong-gu, Gwangju, 501-717, Republic of Korea.
    The Centers for Disease Control and Prevention (CDC) recommend oral or intravenous doxycycline plus a third-generation cephalosporin or fluoroquinolone alone for the treatment of Vibrio vulnificus infections. Until now, no study has compared oral with parenteral administered doxycycline with respect to their in vivo efficacy. In the present work, ICR mice infected with a high dose of V. Read More

    Protective mechanism of curcumin against Vibrio vulnificus infection.
    FEMS Immunol Med Microbiol 2011 Dec 8;63(3):355-62. Epub 2011 Sep 8.
    Department of Oral Microbiology, School of Dentistry, Pusan National University, Yangsan, Korea.
    Curcumin, a natural polyphenolic flavonoid extracted from the rhizome of Curcuma longa L., has many beneficial biological activities. However, there are relatively few reports of the effects of curcumin on pathogen infections. Read More

    Aeromonas hydrophila Sepsis Mimicking Vibrio vulnificus Infection.
    Ann Dermatol 2011 Sep 30;23 Suppl 1:S25-9. Epub 2011 Sep 30.
    Department of Dermatology, Wonkwang University School of Medicine, Iksan, Korea.
    Aeromonas hydrophila is a facultatively anaerobic, asporogenous gram-negative rod that has often been regarded as an opportunistic pathogen in hosts with impairment of a local or general defense mechanism. A 68-year-old alcoholic woman presented with shock and gangrene on the right arm. At first, her clinical presentations were severe painful erythematous swelling that worsened within a few hours with development of gangrene, edema, and blisters. Read More

    Homodimerization and binding of specific domains to the target DNA are essential requirements for HlyU to regulate expression of the virulence gene rtxA1, encoding the repeat-in-toxin protein in the human pathogen Vibrio vulnificus.
    J Bacteriol 2011 Dec 21;193(24):6895-901. Epub 2011 Oct 21.
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239, USA.
    The virulence gene rtxA1, encoding the repeat-in-toxin protein, plays an essential role in the pathogenesis of Vibrio vulnificus infections. Expression of this gene is controlled by the HlyU regulator by direct contact of the DNA upstream of the rtxA1 toxin operon acting as a derepressor of the H-NS protein. The crystal structure suggests that HlyU forms a homodimer in vitro. Read More

    Insights into the antibacterial and immunomodulatory functions of the antimicrobial peptide, epinecidin-1, against Vibrio vulnificus infection in zebrafish.
    Fish Shellfish Immunol 2011 Dec 10;31(6):1019-25. Epub 2011 Sep 10.
    Department of Aquaculture, National Taiwan Ocean University, Keelung 202, Taiwan.
    In the present study, we used Vibrio vulnificus and a zebrafish model system to investigate the inhibitory effect of epinecidin-1 on acute bacterial infection and studied the impacts of pretreatment, co-treatment, and post-treatment with epinecidin-1 on its protective efficacy. In vivo experiments showed that co-treatment with epinecidin-1 and V. vulnificus achieved 78%-97% survival rates after 30 days. Read More

    Necrotising fasciitis caused by Vibrio vulnificus in the lower limb following exposure to seafood on the hand.
    Hong Kong Med J 2011 Aug;17(4):335-7
    Department of Orthopaedics and Traumatology, Caritas Medical Centre, 111 Wing Hong Street, Shamshuipo, Hong Kong.
    Vibrio vulnificus infection mainly manifests as primary bacteraemia or gastroenteritis following injection of the microorganism, and wound infection through direct inoculation. Injury from exposure to the microorganism and development of necrotising fasciitis at a remote site and sepsis are rare. This report is of a high-risk patient with haemoglobin H disease who developed necrotising fasciitis in the lower limb after exposure to seafood on the hand. Read More

    Insights into the antibacterial and immunomodulatory functions of tilapia hepcidin (TH)2-3 against Vibrio vulnificus infection in mice.
    Dev Comp Immunol 2012 Jan 3;36(1):166-73. Epub 2011 Jul 3.
    Department of Aquaculture, National Taiwan Ocean University, Keelung 202, Taiwan.
    The antimicrobial and immunomodulatory functions of the antimicrobial peptide, tilapia hepcidin (TH)2-3, against a bacterial endotoxin under in vitro conditions was previously reported. In this study, we investigated the antibacterial and immunomodulatory functions of TH2-3 in mice infected with the pathogen, Vibrio vulnificus. A TH2-3 injection in V. Read More

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