13,268 results match your criteria Vibrio Infections


Recurrent Cholera Outbreaks, Democratic Republic of the Congo, 2008-2017.

Emerg Infect Dis 2019 May;25(5):856-864

In 2017, the exacerbation of an ongoing countrywide cholera outbreak in the Democratic Republic of the Congo resulted in >53,000 reported cases and 1,145 deaths. To guide control measures, we analyzed the characteristics of cholera epidemiology in DRC on the basis of surveillance and cholera treatment center data for 2008-2017. The 2017 nationwide outbreak resulted from 3 distinct mechanisms: considerable increases in the number of cases in cholera-endemic areas, so-called hot spots, around the Great Lakes in eastern DRC; recurrent outbreaks progressing downstream along the Congo River; and spread along Congo River branches to areas that had been cholera-free for more than a decade. Read More

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http://dx.doi.org/10.3201/eid2505.181141DOI Listing

Isolation and characterisation of pVa-21, a giant bacteriophage with anti-biofilm potential against Vibrio alginolyticus.

Sci Rep 2019 Apr 18;9(1):6284. Epub 2019 Apr 18.

Laboratory of Aquatic Biomedicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea.

There is an increasing emergence of antibiotic-resistant Vibrio alginolyticus, a zoonotic pathogen that causes mass mortality in aquatic animals and infects humans; therefore, there is a demand for alternatives to antibiotics for the treatment and prevention of infections caused by this pathogen. One possibility is through the exploitation of bacteriophages. In the present study, the novel bacteriophage pVa-21 was classified as Myoviridae and characterised as a candidate biocontrol agent against V. Read More

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http://www.nature.com/articles/s41598-019-42681-1
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http://dx.doi.org/10.1038/s41598-019-42681-1DOI Listing
April 2019
1 Read

Integrons and antibiotic resistance genes in water-borne pathogens: threat detection and risk assessment.

J Med Microbiol 2019 Apr 16. Epub 2019 Apr 16.

1 Medical Microbiology and Bioprocess Technology Laboratory, Department of Microbiology, Maharshi Dayanand University, Rohtak, Haryana 124001, India.

Antibiotic-resistant genes (ARGs) are regarded as emerging environmental pollutants and pose a serious health risk to the human population. Integrons are genetic elements that are involved in the spread of ARGs amongst bacterial species. They also act as reservoirs of these resistance traits, further contributing to the development of multi-drug resistance in several water-borne pathogens. Read More

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http://dx.doi.org/10.1099/jmm.0.000972DOI Listing

Non-O1, non-O139 bacteremia in an urban academic medical center in the United States.

IDCases 2019 27;15:e00527. Epub 2019 Mar 27.

Department of Internal Medicine, Wayne State University, Detroit, MI, United States.

Non-O1, non-O139 (NOVC) are genetically diverse strains that are generally non-pathogenic in healthy hosts. In immunocompromised patients or those with liver disease, NOVC have been shown to cause gastroenteritis, wound infections or sepsis and are often associated with high mortality rates. We report a case of a patient with liver cirrhosis and chronic venous insufficiency who was found to have NOVC bacteremia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22142509193005
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http://dx.doi.org/10.1016/j.idcr.2019.e00527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447745PMC
March 2019
2 Reads

Vibrio albensis: An unusual urinary tract infection in a healthy male.

J Infect Public Health 2019 Apr 10. Epub 2019 Apr 10.

Department of Emergency Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Infections with non-O1 non-O139 Vibro cholerae strains have been reported to affect different extra intestinal sites including the urinary tract infection. We report the first case of UTI due to Vibrio albensis in an immunocompetent patient from Lebanon, where the organism was also recovered from water at his home. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18760341193012
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http://dx.doi.org/10.1016/j.jiph.2019.03.018DOI Listing
April 2019
5 Reads

The distribution, expression of the Cu/Zn superoxide dismutase in Apostichopus japonicus and its function for sea cucumber immunity.

Fish Shellfish Immunol 2019 Apr 9. Epub 2019 Apr 9.

Department of Biotechnology, School of Biological Engineering, Dalian Polytechnic University, Dalian, 116034, Liaoning Province, PR China. Electronic address:

Cu/Zn superoxide dismutases (SODs) are antioxidative metalloenzymes that exist ubiquitously in different species and are distributed widely in various tissues and cell types. In this study, the distribution and biological function of the Cu/Zn superoxide dismutase in Apostichopus japonicus (AjSOD1) is first characterized. The AjSOD1 cDNA is 1219 bp in length and contains an open reading frame (ORF) of 459 bp that encodes a protein of 152 amino acids with a deduced molecular weight of 15. Read More

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http://dx.doi.org/10.1016/j.fsi.2019.04.009DOI Listing
April 2019
1 Read

Genetic Relationship, Virulence Factors, Drug Resistance Profile and Biofilm Formation Ability of Isolated From Mussel.

Front Microbiol 2019 20;10:513. Epub 2019 Mar 20.

Department of Food Science and Technology, Advanced Food Safety Research Group, Brain Korea 21 Plus, Chung-Ang University, Anseong, South Korea.

The objective of this study was to investigate the virulence factors, genetic relationship, antibiotic resistance profile and the biofilm formation ability of isolates on shrimp and mussel surfaces at 30°C. In this study, eight ( = 8) isolated from mussel were examined. We used the polymerase chain reaction (PCR) to examine the distribution of different genes, and Repetitive Extragenic Palindromic-PCR (REP-PCR) to compare the genetic relationship. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435529PMC
March 2019
1 Read

Molecular identification and expression analysis of four Lysin motif (LysM) domain-containing proteins from turbot (Scophthalmus maximus).

Fish Shellfish Immunol 2019 Mar 30;89:271-280. Epub 2019 Mar 30.

Marine Science and Engineering College, Qingdao Agricultural University, Qingdao, 266109, PR China. Electronic address:

Lysin motif (LysM) is involved in chitin, peptidoglycan and other structurally-related oligosaccharides recognition and binding, and it is important for the biological processes of responsing to bacterial and viral infections and pathogen defense. LysM is also a widely spread protein, ranging from prokaryotes to eukaryotes, including bacteria, plants and mammals. However, research of LysM in teleosts especially in marine fish was rarely scarce. Read More

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http://dx.doi.org/10.1016/j.fsi.2019.03.074DOI Listing

Saline Environments as a Source of Potential Quorum Sensing Disruptors to Control Bacterial Infections: A Review.

Mar Drugs 2019 Mar 25;17(3). Epub 2019 Mar 25.

Department of Microbiology, Faculty of Pharmacy, University of Granada, 18071 Granada, Spain.

Saline environments, such as marine and hypersaline habitats, are widely distributed around the world. They include sea waters, saline lakes, solar salterns, or hypersaline soils. The bacteria that live in these habitats produce and develop unique bioactive molecules and physiological pathways to cope with the stress conditions generated by these environments. Read More

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http://dx.doi.org/10.3390/md17030191DOI Listing
March 2019
1 Read

Molecular mechanisms of Vibrio parahaemolyticus pathogenesis.

Microbiol Res 2019 May 8;222:43-51. Epub 2019 Mar 8.

Jiangsu Key Laboratory of Zoonosis/Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, 225009, China; Joint International Research Laboratory of Agriculture and Agri-Product Safety/Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agrifood Safety and Quality, The Ministry of Education of China, Yangzhou University, Yangzhou, 225009, China.

Vibrio parahaemolyticus is a Gram-negative halophilic bacterium that is mainly distributed in the seafood such as fish, shrimps and shellfish throughout the world. V. parahaemolyticus can cause diseases in marine aquaculture, leading to huge economic losses to the aquaculture industry. Read More

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http://dx.doi.org/10.1016/j.micres.2019.03.003DOI Listing

Potentially human-virulent Vibrio vulnificus isolates from diseased great pompano (Trachinotus goodei).

Transbound Emerg Dis 2019 Mar 30. Epub 2019 Mar 30.

ERI BioTecMed, University of Valencia, Valencia, Spain.

Vibrio vulnificus is an opportunistic human pathogen responsible for the majority of seafood-associated deaths worldwide and is also a relevant fish pathogen for the aquaculture industry. In addition to infections in aquatic livestock, V. vulnificus also represents a risk to aquarium animals. Read More

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http://dx.doi.org/10.1111/tbed.13190DOI Listing
March 2019
1 Read

O6 gastroenteritis in a patient with lupus nephritis - a report from coastal Karnataka, South India.

JMM Case Rep 2019 Jan 19;6(1):e005171. Epub 2018 Dec 19.

Enteric Diseases Division, Central Research Lab, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.

Introduction: O1 strains are responsible for pandemics of cholera and major epidemics in the world. All the remaining non-O1/non-O139 strains are less virulent and are responsible for sporadic cases of gastroenteritis. These non-O1/non-O139 serogroups have more than 200 somatic antigens, and mostly lack cholera toxin and toxin co-regulated pilus encoding genes. Read More

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http://www.microbiologyresearch.org/content/journal/jmmcr/10
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http://dx.doi.org/10.1099/jmmcr.0.005171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412036PMC
January 2019
7 Reads

Metabolic mechanism of ceftazidime resistance in .

Infect Drug Resist 2019 13;12:417-429. Epub 2019 Feb 13.

Center for Proteomics and Metabolomics, State Key Laboratory of Biocontrol, Guangdong Province Key Laboratory for Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-sen University, University City, Guangzhou 510006, People's Republic of China,

Background: Microbial metabolism confounds antibiotic efficacy. However, information regarding effect of metabolism on cephalosporin antibiotics-mediated killing and is largely absence, although the drugs are widely used in clinic and the bacteria are pathogens to both human and aquaculture animals.

Purpose: This study explores the metabolome of cephalosporin antibiotic-resistant and analyzes the role of bacterial metabolism in drug and multidrug-resistance. Read More

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http://dx.doi.org/10.2147/IDR.S179639DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388739PMC
February 2019
5 Reads

Investigating a cholera outbreak in Kaiso Fishing Village, Hoima District, Uganda, October 2015.

Pan Afr Med J 2018 18;30(Suppl 1):14. Epub 2018 May 18.

Uganda Public Health Fellowship Program, Kampala, Uganda.

Globally, even though improvements have been made to effective surveillance and response, communicable diseases such as cholera remain high priorities for national health programs, especially in Africa. High-quality surveillance information coupled with adequate laboratory facilities are effective in curbing outbreaks from such diseases, ultimately reducing morbidity and mortality. One way of building this capacity is through simulation of response to such health events. Read More

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http://dx.doi.org/10.11604/pamj.supp.2018.30.1.15281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379599PMC
March 2019
2 Reads

Cholera outbreak in a fishing village in Uganda: a case study.

Pan Afr Med J 2018 17;30(Suppl 1). Epub 2018 May 17.

Uganda Public Health Fellowship Program, Kampala, Uganda.

In June 2015, the District Health Officer of Kasese District, southwestern Uganda reported an outbreak of cholera in a fishing village. Two fellows of the Uganda Public Health Fellowship Program - Field Epidemiology Track conducted an investigation to verify the existence of an outbreak, determine the mode of transmission, and recommend control measures. This case study describes that investigation, which teaches the steps in an outbreak investigation and the details in each step, what needs to be done in each step to achieve the objectives of the investigation, and what might be the common pitfalls during an outbreak investigation. Read More

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http://dx.doi.org/10.11604/pamj.supp.2018.30.1.15268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379547PMC
March 2019
1 Read

Challenges in Vibrio parahaemolyticus infections caused by the pandemic clone.

Future Microbiol 2019 Mar 11;14:437-450. Epub 2019 Mar 11.

National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology, Beijing, People's Republic of China.

Vibrio Parahaemolyticus infections caused by the pandemic clone have become a global public health issue. The pandemic clone includes over ten sequence types and 49 serotypes. Several markers such as toxRS/new, orf8 and genomic islands were considered specific for pandemic strains, but subsequent studies later confirmed a lack of specificity. Read More

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https://www.futuremedicine.com/doi/10.2217/fmb-2018-0308
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http://dx.doi.org/10.2217/fmb-2018-0308DOI Listing
March 2019
7 Reads

Studies on formulation of a combination heat killed immunogen from diarrheagenic Escherichia coli and Vibrio cholerae in RITARD model.

Microbes Infect 2019 Mar 7. Epub 2019 Mar 7.

Division of Bacteriology, National Institute of Cholera and Enteric Diseases, P-33 C.I.T. Road, Scheme-XM, Beliaghata, Kolkata, 700010, India. Electronic address:

Multiple diarrheagenic enteric bacterial infections cause global morbidity and mortality. A combination vaccine is needed to combat different diarrhea-causing organisms. In our present work, we formulated a combination of antigens from three different diarrheagenic Escherichia coli strains and three different Vibrio cholerae strains. Read More

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http://dx.doi.org/10.1016/j.micinf.2019.02.007DOI Listing
March 2019
2 Reads

Ethanolic extract of red seaweed Gracilaria fisheri and furanone eradicate Vibrio harveyi and Vibrio parahaemolyticus biofilms and ameliorate the bacterial infection in shrimp.

Fish Shellfish Immunol 2019 May 25;88:91-101. Epub 2019 Feb 25.

Department of Anatomy, Faculty of Science, Mahidol University, Rama VI Road, Bangkok, Thailand. Electronic address:

Bacteria respond to host immunity for their proliferation and survival by cell-cell communications such as biofilm formation, bioluminescence, and secreting virulence factors. In the biofilm form, bacteria are more resistant to various antimicrobial treatments and withstand the host's immune system. The approaches of deciphering biofilm formation for treating bacterial infections are therefore highly desirable. Read More

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http://dx.doi.org/10.1016/j.fsi.2019.01.058DOI Listing
May 2019
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Comparative Study of Immune Reaction Against Bacterial Infection From Transcriptome Analysis.

Front Immunol 2019 5;10:153. Epub 2019 Feb 5.

Department of Veterinary Medicine, College of Veterinary Medicine, National Pingtung University of Science and Technology, Pingtung, Taiwan.

Transcriptome analysis is a powerful tool that enables a deep understanding of complicated physiological pathways, including immune responses. RNA sequencing (RNA-Seq)-based transcriptome analysis and various bioinformatics tools have also been used to study non-model animals, including aquaculture species for which reference genomes are not available. Rapid developments in these techniques have not only accelerated investigations into the process of pathogenic infection and defense strategies in fish, but also used to identify immunity-related genes in fish. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370674PMC
February 2019
5 Reads

Transcriptome analysis and discovery of genes involved in immune pathways in Solen strictus (Gould, 1861) under Vibrio anguillarum.

Fish Shellfish Immunol 2019 May 18;88:237-243. Epub 2019 Feb 18.

Department of Animal Nutrition and Aquaculture, Shandong Vocational Animal Science and Veterinary College, 88 Shengli East Street, Weifang 261061, China. Electronic address:

The Solen strictus (Gould, 1861) has been recognized as an important marine economic bivalve in Eastern and Southeast Asia. To gain a better understanding of the S. strictus immune system and its related genes in response to bacterial infections, we performed a comparative gene transcription analysis from S. Read More

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http://dx.doi.org/10.1016/j.fsi.2019.01.024DOI Listing
May 2019
2 Reads

Estimating cholera incidence with cross-sectional serology.

Sci Transl Med 2019 Feb;11(480)

Division of Infectious Diseases, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.

The development of new approaches to cholera control relies on an accurate understanding of cholera epidemiology. However, most information on cholera incidence lacks laboratory confirmation and instead relies on surveillance systems reporting medically attended acute watery diarrhea. If recent infections could be identified using serological markers, cross-sectional serosurveys would offer an alternative approach to measuring incidence. Read More

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http://dx.doi.org/10.1126/scitranslmed.aau6242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430585PMC
February 2019
2 Reads

Evolutionary Model of Cluster Divergence of the Emergent Marine Pathogen : From Genotype to Ecotype.

MBio 2019 02 19;10(1). Epub 2019 Feb 19.

Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida, USA

, an opportunistic pathogen, is the causative agent of a life-threatening septicemia and a rising problem for aquaculture worldwide. The genetic factors that differentiate its clinical and environmental strains remain enigmatic. Furthermore, clinical strains have emerged from every clade of In this work, we investigated the underlying genomic properties and population dynamics of the species from an evolutionary and ecological point of view. Read More

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http://dx.doi.org/10.1128/mBio.02852-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381281PMC
February 2019
1 Read

Endopeptidase Regulation as a Novel Function of the Zur-Dependent Zinc Starvation Response.

MBio 2019 02 19;10(1). Epub 2019 Feb 19.

Department of Microbiology, Cornell University, Ithaca, New York, USA

The cell wall is a strong, yet flexible, meshwork of peptidoglycan (PG) that gives a bacterium structural integrity. To accommodate a growing cell, the wall is remodeled by both PG synthesis and degradation. encodes a group of three nearly identical zinc-dependent endopeptidases (EPs) that are predicted to hydrolyze PG to facilitate cell growth. Read More

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http://dx.doi.org/10.1128/mBio.02620-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381278PMC
February 2019
2 Reads

Export of a Vibrio parahaemolyticus toxin by the Sec and type III secretion machineries in tandem.

Nat Microbiol 2019 Feb 18. Epub 2019 Feb 18.

Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan.

Many Gram-negative pathogens utilize dedicated secretion systems to export virulence factors such as exotoxins and effectors. Several exotoxins are synthesized as precursors containing amino-terminal Sec signal peptides and are exported through the inner-membrane-bound Sec machinery to the periplasm, followed by secretion across the outer membrane to the exterior using a type II secretion system (T2SS). Here, we report that thermostable direct haemolysin (TDH), an exotoxin of the food-borne pathogen Vibrio parahaemolyticus, can be exported through the type III secretion system (T3SS), which engages in one-step secretion of effectors, despite possessing a Sec signal peptide and being mainly secreted via the T2SS. Read More

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http://dx.doi.org/10.1038/s41564-019-0368-yDOI Listing
February 2019

Identification of Essential Genes of for Establishment of Wound Infection by Signature-Tagged Mutagenesis.

Front Microbiol 2019 1;10:123. Epub 2019 Feb 1.

Laboratory of Veterinary Public Health, School of Veterinary Medicine, Kitasato University, Towada, Japan.

can cause severe necrotic lesions within a short time. Recently, it has been reported that the numbers of wound infection cases in healthy hosts are increasing, for which surgical procedures are essential in many instances to eliminate the pathogen owing to its rapid proliferation. However, the mechanisms by which can achieve wound infection in healthy hosts have not been elucidated. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367243PMC
February 2019
1 Read

Stenotrophomonas maltophilia AHL-Degrading Strains Isolated from Marine Invertebrate Microbiota Attenuate the Virulence of Pectobacterium carotovorum and Vibrio coralliilyticus.

Mar Biotechnol (NY) 2019 Apr 14;21(2):276-290. Epub 2019 Feb 14.

Department of Microbiology, Faculty of Pharmacy, University of Granada, 18071, Granada, Spain.

Many Gram-negative aquacultural and agricultural pathogens control virulence factor expression through a quorum-sensing (QS) mechanism involving the production of N-acylhomoserine (AHL) signalling molecules. Thus, the interruption of QS systems by the enzymatic degradation of signalling molecules, known as quorum quenching (QQ), has been proposed as a novel strategy to combat these infections. Given that the symbiotic bacteria of marine invertebrates are considered to be an important source of new bioactive molecules, this study explores the presence of AHL-degrading bacteria among 827 strains previously isolated from the microbiota of anemones and holothurians. Read More

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http://dx.doi.org/10.1007/s10126-019-09879-wDOI Listing
April 2019
2 Reads

Quorum sensing is required for full virulence of Vibrio campbellii towards tiger grouper (Epinephelus fuscoguttatus) larvae.

J Fish Dis 2019 Apr 11;42(4):489-495. Epub 2019 Feb 11.

Department of Aquaculture, Faculty of Agriculture, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.

The link between quorum sensing in Vibrio campbellii and its virulence towards tiger grouper (Epinephelus fuscoguttatus) was investigated using V. campbellii wild type and quorum-sensing mutants with inactive quorum sensing or constitutively maximal quorum-sensing activity, and signal molecule synthase mutants. The results showed that wild-type V. Read More

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http://dx.doi.org/10.1111/jfd.12946DOI Listing
April 2019
2 Reads

A foodborne outbreak of gastroenteritis caused by Vibrio parahaemolyticus associated with cross-contamination from squid in Korea.

Authors:
Sun-Wha Jung

Epidemiol Health 2018 13;40:e2018056. Epub 2018 Nov 13.

Environmental Health Division, Seoul Metropolitan Government, Seoul, Korea.

Objectives: Water-borne diseases caused by Vibrio parahemolyticus are often known to cause gastritis when raw or undercooked seafood is eaten. It is very rare that Vibrio gastritis caused by ingesting non-seafood products occurs on a large scale. On September 19, 2017, a large-scale Vibrio gastritis occurred after the city residents consumed food at a bazaar held in a welfare center in Jungnang-gu, Seoul. Read More

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http://dx.doi.org/10.4178/epih.e2018056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367201PMC
February 2019

Monomicrobial gram-negative necrotizing fasciitis: An uncommon but fatal syndrome.

Diagn Microbiol Infect Dis 2019 Jan 4. Epub 2019 Jan 4.

Division of Infectious Diseases, Department of Internal Medicine, Soonchunhyang University Seoul Hospital, Soonchunhyang University College of Medicine, Seoul, Republic of Korea. Electronic address:

This study aimed to characterize patients with monomicrobial gram-negative necrotizing fasciitis in three university hospitals in Korea. In this study, of the 115 patients with community-acquired necrotizing fasciitis, 67 (58%) had monomicrobial infections: 31 (27%) in the gram-negative group and 36 (31%) in the gram-positive group. The majority of patients in the gram-negative group were infected with Escherichia coli followed by Klebsiella pneumoniae and Vibrio vulnificus. Read More

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http://dx.doi.org/10.1016/j.diagmicrobio.2018.12.013DOI Listing
January 2019
5 Reads

Vibrio variations on a type three theme.

Curr Opin Microbiol 2019 Jan 31;47:66-73. Epub 2019 Jan 31.

Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, United States. Electronic address:

Mounting evidence suggests that Type 3 Secretion Systems (T3SS) are widespread among Vibrio species, and are present in strains isolated from diverse sources such as human clinical infections, environmental reservoirs, and diseased marine life. Experiments evaluating Vibrio parahaemolyticus and Vibrio cholerae T3SS mediated virulence suggest that Vibrio T3SS pathogenicity islands have a tripartite composition. A conserved 'core' region encodes functions essential for colonization and disease in vivo, including modulation of innate immune signaling pathways and actin dynamics, whereas regions flanking core sequences are variable among strains and encode effector proteins performing a diverse array of activities. Read More

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http://dx.doi.org/10.1016/j.mib.2018.12.001DOI Listing
January 2019
2 Reads

A cholera outbreak in a rural north central Nigerian community: an unmatched case-control study.

BMC Public Health 2019 Jan 25;19(1):112. Epub 2019 Jan 25.

Global Public Health Solutions, Atlanta, USA.

Background: Cholera remains a disease of public health importance in Nigeria associated with high morbidity and mortality. In November 2014, the Nigeria Field Epidemiology and Laboratory Training Programme (NFELTP) was notified of an increase in suspected cholera cases in Gomani, Kwali Local Government Area. NFELTP residents were deployed to investigate the outbreak with the objectives of verifying the diagnosis, identifying risk factors and instituting appropriate control measures to control the outbreak. Read More

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http://dx.doi.org/10.1186/s12889-018-6299-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347749PMC
January 2019
3 Reads

Multidrug-Resistant Bacteria Associated with Cell Phones of Healthcare Professionals in Selected Hospitals in Saudi Arabia.

Can J Infect Dis Med Microbiol 2018 24;2018:6598918. Epub 2018 Dec 24.

Department of Medical Equipment Technology, College of Applied Medical Sciences, Majmaah University, Majmaah 11952, Saudi Arabia.

Cell phones may be an ideal habitat for colonization by bacterial pathogens, especially in hot climates, and may be a reservoir or vehicle in transmitting nosocomial infections. We investigated bacterial contamination on cell phones of healthcare workers in three hospitals in Saudi Arabia and determined antibacterial resistance of selected bacteria. A questionnaire was submitted to 285 healthcare workers in three hospitals, and information was collected on cell phone usage at the work area and in the toilet, cell phone cleaning and sharing, and awareness of cell phones being a source of infection. Read More

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https://www.hindawi.com/journals/cjidmm/2018/6598918/
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http://dx.doi.org/10.1155/2018/6598918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323467PMC
December 2018
10 Reads

Genomics can help to monitor cholera.

Authors:

Nature 2019 01;565(7740):397-398

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http://dx.doi.org/10.1038/d41586-019-00206-wDOI Listing
January 2019
2 Reads

Investigating the virulence genes and antibiotic susceptibility patterns of Vibrio cholerae O1 in environmental and clinical isolates in Accra, Ghana.

BMC Infect Dis 2019 Jan 21;19(1):76. Epub 2019 Jan 21.

Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Legon, Ghana.

Background: Cholera has been endemic in Ghana since its detection in 1970. It has been shown that long-term survival of the bacteria may be attained in aquatic environments. Consequently, cholera outbreaks may be triggered predominantly in densely populated urban areas. Read More

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http://dx.doi.org/10.1186/s12879-019-3714-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341726PMC
January 2019

Cholera.

Authors:
Richard Barnett

Lancet 2019 01;393(10168):218

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http://dx.doi.org/10.1016/S0140-6736(19)30006-6DOI Listing
January 2019

Acetate Kinase (AcK) is Essential for Microbial Growth and Betel-derived Compounds Potentially Target AcK, PhoP and MDR Proteins in M. tuberculosis, V. cholerae and Pathogenic E. coli: An in silico and in vitro Study.

Curr Top Med Chem 2018 ;18(31):2731-2740

PG Program in Bioinformatics (LGCM), Institute of Biologic Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.

Background: Mycobacterium tuberculosis, Vibrio cholerae, and pathogenic Escherichia coli are global concerns for public health. The emergence of multi-drug resistant (MDR) strains of these pathogens is creating additional challenges in controlling infections caused by these deadly bacteria. Recently, we reported that Acetate kinase (AcK) could be a broad-spectrum novel target in several bacteria including these pathogens. Read More

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http://dx.doi.org/10.2174/1568026619666190121105851DOI Listing
April 2019
5 Reads
3.402 Impact Factor

Fatal case of necrotising fasciitis due to in a patient with alcoholic liver disease and diabetes mellitus.

BMJ Case Rep 2019 Jan 17;12(1). Epub 2019 Jan 17.

Internal Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

is a halophilic found globally. They are thought to be normal microbiome in the estuaries along the coasts associated with seawater and seashells. Infection usually results from consumption of raw oysters or shellfish or exposure of broken skin or open wounds to contaminated salt or brackish water. Read More

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http://dx.doi.org/10.1136/bcr-2018-227851DOI Listing
January 2019
5 Reads

Niche adaptation limits bacteriophage predation of in a nutrient-poor aquatic environment.

Proc Natl Acad Sci U S A 2019 01 11;116(5):1627-1632. Epub 2019 Jan 11.

Department of Molecular Biology and Microbiology, Tufts University, Boston, MA 02111

, the causative agent of cholera, has reservoirs in fresh and brackish water where it interacts with virulent bacteriophages. Phages are the most abundant biological entity on earth and coevolve with bacteria. It was reported that concentrations of phage and inversely correlate in aquatic reservoirs and in the human small intestine, and therefore that phages may quench cholera outbreaks. Read More

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http://www.pnas.org/lookup/doi/10.1073/pnas.1810138116
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http://dx.doi.org/10.1073/pnas.1810138116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358685PMC
January 2019
2 Reads

Using the wax moth larva infection model to detect emerging bacterial pathogens.

PeerJ 2019 4;6:e6150. Epub 2019 Jan 4.

European Centre for Environment and Human Health, University of Exeter, Penryn, UK.

Climate change, changing farming practices, social and demographic changes and rising levels of antibiotic resistance are likely to lead to future increases in opportunistic bacterial infections that are more difficult to treat. Uncovering the prevalence and identity of pathogenic bacteria in the environment is key to assessing transmission risks. We describe the first use of the Wax moth larva , a well-established model for the mammalian innate immune system, to selectively enrich and characterize pathogens from coastal environments in the South West of the UK. Read More

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https://peerj.com/articles/6150
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http://dx.doi.org/10.7717/peerj.6150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322482PMC
January 2019
13 Reads

[Bacteria that eat human lurking in the Ariake Sea- infection].

Rinsho Biseibutshu Jinsoku Shindan Kenkyukai Shi 2018 Dec;28(2):49-57

Shida Hospital.

There are currently 76 species of bacteria in the genus , which is a halophilic gram-negative bacillus, 12 of which are pathogenic in humans. It is usually known as a foodborn infectious bacterium related to gastrointestinal tract. develops muscle tissue necrosis of limb and septic shock in 1 to 3 days when infected in patients with liver injury or immune function deterioration and many die from multiple organ dysfunction. Read More

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December 2018
4 Reads

Genomic and biological characterization of the Vibrio alginolyticus-infecting "Podoviridae" bacteriophage, vB_ValP_IME271.

Virus Genes 2019 Apr 9;55(2):218-226. Epub 2019 Jan 9.

The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510000, China.

As an opportunist pathogen, Vibrio alginolyticus (V. alginolyticus), causes disease in marine animals. Bacterial contamination of seafood is not uncommon, and phage therapy is considered a safe way to decontaminate such foods to control the emergence of vibriosis. Read More

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http://link.springer.com/10.1007/s11262-018-1622-8
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http://dx.doi.org/10.1007/s11262-018-1622-8DOI Listing
April 2019
23 Reads

Pathogenomics of Virulence Traits of That Were Deemed Inconclusive by Traditional Experimental Approaches.

Front Microbiol 2018 21;9:3077. Epub 2018 Dec 21.

SAMRC Microbial Water Quality Monitoring Centre, University of Fort Hare, Alice, South Africa.

One of the major challenges of modern medicine includes the failure of conventional protocols to characterize the pathogenicity of emerging pathogens. This is particularly apparent in the case of . Although a number of infections have been linked to this microorganism, experimental evidence of its virulence factors (VFs), obtained by traditional approaches, is somewhat inconclusive. Read More

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http://dx.doi.org/10.3389/fmicb.2018.03077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309461PMC
December 2018
1 Read

Evaluation of integrated disease surveillance and response (IDSR) core and support functions after the revitalisation of IDSR in Uganda from 2012 to 2016.

BMC Public Health 2019 Jan 9;19(1):46. Epub 2019 Jan 9.

Global Public Health Solutions Inc, Atlanta, GA, USA.

Background: Uganda is a low income country that continues to experience disease outbreaks caused by emerging and re-emerging diseases such as cholera, meningococcal meningitis, typhoid and viral haemorrhagic fevers. The Integrated Disease Surveillance and Response (IDSR) strategy was adopted by WHO-AFRO in 1998 as a comprehensive strategy to improve disease surveillance and response in WHO Member States in Africa and was adopted in Uganda in 2000. To address persistent inconsistencies and inadequacies in the core and support functions of IDSR, Uganda initiated an IDSR revitalisation programme in 2012. Read More

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http://dx.doi.org/10.1186/s12889-018-6336-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327465PMC
January 2019
3 Reads

Expanded table: Some vaccines for travelers.

Authors:

Med Lett Drugs Ther 2018 Nov 19;60(1560):e192-e194. Epub 2018 Nov 19.

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November 2018
18 Reads

Vaccines for travelers.

Authors:

Med Lett Drugs Ther 2018 Nov;60(1560):185-192

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November 2018
19 Reads

Crystal structure of the VqmA-ligand-DNA complex provides insight into ligand-binding mechanisms relevant for drug design.

J Biol Chem 2019 02 4;294(8):2580-2592. Epub 2019 Jan 4.

From the Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 and

VqmA is a highly conserved transcriptional regulator of the quorum-sensing system of , a major human pathogen that continues to imperil human health. VqmA represses biofilm formation and plays an important role in pathogenicity in the human host. Although VqmA's biological function is well understood, the molecular mechanisms by which its specific ligand (and effector), 3,5-dimethylpyrazine-2-ol (DPO), controls transcription of the target gene, , remain obscure. Read More

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http://dx.doi.org/10.1074/jbc.RA118.006082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393613PMC
February 2019
4 Reads

Responses of Gene to Infection and Thermal Stress and Its Transcriptional Regulation Analysis in .

Molecules 2019 Jan 3;24(1). Epub 2019 Jan 3.

College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China.

Heat-shock protein 70 (HSP70) is a molecular chaperone that plays critical roles in cell protein folding and metabolism, which helps to protect cells from unfavorable environmental stress. is one of the most important economic breeding species in the coastal provinces of south China. To date, the expression and transcriptional regulation of in () has not been well characterized. Read More

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http://www.mdpi.com/1420-3049/24/1/162
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http://dx.doi.org/10.3390/molecules24010162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337134PMC
January 2019
12 Reads

Epidemiological description of a protracted cholera outbreak in Tonj East and Tonj North counties, former Warrap State, South Sudan, May-Oct 2017.

BMC Infect Dis 2019 Jan 3;19(1). Epub 2019 Jan 3.

World Health Organization Country Office, Juba, South Sudan.

Background: On 18th May 2017, State Ministry of Health of former Warrap State received a report from Tonj East County of an outbreak of acute watery diarrhoea and vomiting in Makuac payam. We conducted this investigation to confirm the causative organism and describe the epidemiology of the outbreak in order to support evidence-based control measures.

Methods: We defined a suspected case as a resident of Tonj East or Tonj North County with sudden onset of acute watery diarrhoea and vomiting between May 1 and October 15, 2017. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3640-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318988PMC
January 2019
1 Read

Characteristics of bacterial isolates in Swiss farmed and ornamental fish from a retrospective study from 2000 to 2017.

Schweiz Arch Tierheilkd 2019 Jan;161(1):43-57

Centre for Fish and Wildlife Health, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern.

Introduction: Aquaculture is a rapidly growing field of food production of high economic importance. Bacterial infections are an important threat to aquaculture growth and also a common problem in ornamental fish. Some pathogenic agents and aquaculture production types are reported to be associated with increased disease. Read More

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http://sat.gstsvs.ch/de/pubmed/?doi=10.17236/sat00193
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http://dx.doi.org/10.17236/sat00193DOI Listing
January 2019
1 Read