14,993 results match your criteria Vibrio Infections

Biomimetic Nanosponges Enable the Detoxification of Hemolysin.

Int J Mol Sci 2022 Jun 19;23(12). Epub 2022 Jun 19.

Department of Marine Biomedicine and Polar Medicine, Naval Special Medical Center, Naval Medical University, Shanghai 200433, China.

() infection-associated multiple antibiotic resistance has raised serious public health concerns. Recently, nanosponges (NSs) have been expected to provide innovative platforms for addressing antibacterial and drug-resistant challenges by targeting various pore-forming toxins (PFTs). In the present study, we constructed NSs to explore the effects and possible mechanism of recombinant hemolysin (rVvhA)-induced injuries. Read More

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Gender-Specific Metabolic Responses of to Infection with and Lipopolysaccharide.

Antioxidants (Basel) 2022 Jun 15;11(6). Epub 2022 Jun 15.

School of Life Science, Huizhou University, Huizhou 516007, China.

Gender differences in the hemocyte immune response of Hong Kong oyster to and lipopolysaccharide (LPS) infection exist. To determine if a gender difference also exists, we use a H NMR-based metabolomics method to investigate responses in hepatopancreas tissues to and LPS infection. Both infections induced pronounced gender- and immune-specific metabolic responses in hepatopancreas tissues. Read More

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Sparus aurata and Lates calcarifer skin microbiota under healthy and diseased conditions in UV and non-UV treated water.

Anim Microbiome 2022 Jun 21;4(1):42. Epub 2022 Jun 21.

Israel Oceanographic and Limnological Research Ltd., The National Center for Mariculture, Eilat, Israel.

Background: The welfare of farmed fish is influenced by numerous environmental and management factors. Fish skin is an important site for immunity and a major route by which infections are acquired. The objective of this study was to characterize bacterial composition variability on skin of healthy, diseased, and recovered Gilthead Seabream (Sparus aurata) and Barramundi (Lates calcarifer). Read More

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Impact of Gene Repression on Biofilm Formation of .

Front Microbiol 2022 2;13:912297. Epub 2022 Jun 2.

Institute of Molecular Biosciences, University of Graz, Graz, Austria.

, the etiological agent of cholera, is a facultative intestinal pathogen which can also survive in aquatic ecosystems in the form of biofilms, surface-associated microbial aggregates embedded in an extracellular matrix, which protects them from predators and hostile environmental factors. Biofilm-derived bacteria and biofilm aggregates are considered a likely source for cholera infections, underscoring the importance of biofilm research not just to better understand bacterial ecology, but also cholera pathogenesis in the human host. While several studies focused on factors induced during biofilm formation, genes repressed during this persistence stage have been fairly neglected. Read More

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Infectious Disease Control and Management in Ethiopia: A Case Study of Cholera.

Front Public Health 2022 30;10:870276. Epub 2022 May 30.

Clinical Trials Directorate, Armauer Hansen Research Institute, Addis Ababa, Ethiopia.

Cholera remains a significant public health problem among the vulnerable populations living in many resource-limited settings with poor access to safe and clean water and hygiene practice. Around 2.86 million cholera cases and 95,000 deaths are estimated to occur in endemic countries. Read More

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Multilocus Sequence Typing and Virulence Potential of Strains Isolated from Aquatic Bird Feces.

Microbiol Spectr 2022 Jun 13:e0088622. Epub 2022 Jun 13.

Department of Microbiology, Faculty of Public Health, Mahidol Universitygrid.10223.32, Bangkok, Thailand.

Vibrio parahaemolyticus is a Gram-negative, foodborne pathogenic bacterium that causes human gastroenteritis. This organism is ubiquitously present in the marine environment. Detection of V. Read More

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Orf1B controls secretion of T3SS proteins and contributes to Edwardsiella piscicida adhesion to epithelial cells.

Vet Res 2022 Jun 13;53(1):40. Epub 2022 Jun 13.

State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, 430072, Hubei, China.

Edwardsiella piscicida is a Gram-negative enteric pathogen that causes hemorrhagic septicemia in fish. The type III secretion system (T3SS) is one of its two most important virulence islands. T3SS protein EseJ inhibits E. Read More

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Thanks, but no thanks: Cholera pathogen keeps incoming DNA at bay.

Cell Host Microbe 2022 06;30(6):877-879

Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32816, USA; National Center for Integrated Coastal Research, University of Central Florida, Orlando, FL 32816, USA. Electronic address:

Bacterial pathogens must maintain a delicate balance between acquiring novel genetic material and preserving their well-engrained cell physiology. In the recent study by Jaskólska et al., an astonishing example of this sophisticated phenomenon was found in Vibrio cholerae,with the pandemic strain encoding systems within two horizontally acquired pathogenicity islands that degrade incoming DNA. Read More

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Synergistic Interaction of Low Salinity Stress With Infection Causes Mass Mortalities in the Oyster by Inducing Host Microflora Imbalance and Immune Dysregulation.

Front Immunol 2022 19;13:859975. Epub 2022 May 19.

Key Laboratory of Mariculture, Ministry of Education, and College of Fisheries, Ocean University of China, Qingdao, China.

A sudden drop in salinity following extreme precipitation events usually causes mass mortality of oysters exposed to pathogens in ocean environment. While how low salinity stress interacts with pathogens to cause mass mortality remains obscure. In this study, we performed an experiment by low salinity stress and pathogen infection with to investigate their synergistic effect on the mortality of the Pacific oyster toward understanding of the interaction among environment, host, and pathogen. Read More

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Diarrhea-Causing Bacteria and Their Antibiotic Resistance Patterns Among Diarrhea Patients From Ghana.

Front Microbiol 2022 19;13:894319. Epub 2022 May 19.

College of Health Sciences, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.

Diarrheal disease remains a major global health problem particularly in children under 5 years and the emergence of antibiotic-resistant strains of causative pathogens could slow control efforts, particularly in settings where treatment options are limited. This surveillance study conducted in Ghana aimed to determine the prevalence and antimicrobial susceptibility profile of diarrhea-causing bacteria. This was a cross-sectional study carried out in five health facilities in the Ga West Municipality of Ghana between 2017 and 2021. Read More

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Antimicrobial activity and mechanisms of a derived antimicrobial peptide TroNKL-27 from golden pompano (Trachinotus ovatus) NK-lysin.

Fish Shellfish Immunol 2022 Jul 2;126:357-369. Epub 2022 Jun 2.

State Key Laboratory of Marine Resource Utilization in South China Sea, Hainan University, PR China; Hainan Provincial Key Laboratory for Tropical Hydrobiology and Biotechnology, College of Marine Science, Hainan University, PR China. Electronic address:

NK-lysin, a homologue of granulysin among human, is predominantly found in natural killer cells and cytotoxic T-lymphocytes, which plays a pivotal part in innate immune responses against diverse pathogenic bacteria. Nonetheless, in teleosts, the research on antimicrobial activity and mechanisms of NK-lysin are seldom reported. In this study, we determined the antimicrobial activity of the truncated peptide TroNKL-27 that derived from golden pompano (Trachinotus ovatus) NK-lysin, and investigated its antimicrobial mechanisms. Read More

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Vibrio cholerae: a pathogen shared by human and aquatic animals.

Lancet Microbe 2022 Jun;3(6):e402

Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, China. Electronic address:

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Outbreak investigation of acute watery diarrhea in a village of North India: timely action saved lives.

J Infect Dev Ctries 2022 05 30;16(5):843-849. Epub 2022 May 30.

Postgraduate Institute of Medical Sciences and Research (PGIMER), Chandigarh (U.T.), India.

Introduction: Outbreaks of acute watery diarrhoea are common in developing countries having poor access to safe drinking water and sanitation. An outbreak of acute watery diarrhoea in a village in North India was investigated with the aim to initiate and recommend necessary actions to control it.

Methodology: A house to house survey using a specially designed case record form was conducted covering all the households. Read More

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Economic impact of cholera in households in rural southern Malawi: a prospective study.

BMJ Open 2022 Jun 1;12(6):e052337. Epub 2022 Jun 1.

Policy and Economic Research, International Vaccine Institute, Seoul, The Republic of Korea

Introduction: Cholera remains a significant contributor to diarrhoeal illness, especially in sub-Saharan Africa. Few studies have estimated the cost of illness (COI) of cholera in Malawi, a cholera-endemic country. The present study estimated the COI of cholera in Nsanje, southern Malawi, as part of the Cholera Surveillance in Malawi (CSIMA) programme following a mass cholera vaccination campaign in 2015. Read More

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Effect of low-frequency noise on the survival rate and immunity of infected Vibrio parahaemolyticus sea slug (Onchidium reevesii).

Fish Shellfish Immunol 2022 Jul 26;126:227-236. Epub 2022 May 26.

National Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai, 201306, China; International Research Center for Marine Biosciences, Ministry of Science and Technology, Shanghai Ocean University, Shanghai, 201306, China; Shanghai Collaborative Innovation Center for Cultivating Elite Breeds and Green-culture of Aquaculture Animals, Shanghai Ocean University, Shanghai, 201306, China. Electronic address:

Anthropogenic noise in the marine environment has become a global environmental pollutant that affects the behavior, physiology and immunity of marine animals. However, the resistance of marine animals to pathogens while under the influence of noise is a topic that has received little attention. To assess the immune defense response of sea slugs against pathogens when exposed to low frequency noise, we performed 120 h exposure experiments on sea slugs after a Vibrio parahaemolyticus application in low frequency noise at 500 Hz and 1000 Hz. Read More

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Immunization with a bicistronic DNA vaccine modulates systemic IFN-γ and IL-10 expression against infection.

J Med Microbiol 2022 May;71(5)

Medical Genetics Laboratory, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.

Cholera is an acute enteric infection caused by , particularly in areas lacking access to clean water. Despite the global effort to improve water quality in these regions, the burden of cholera in recent years has not yet declined. Interest has therefore extended in the use of bicistronic DNA vaccine encoding and genes of as a potential vaccine. Read More

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In-hospital mortality associated with necrotizing soft tissue infection due to Vibrio vulnificus: a matched-pair cohort study.

World J Emerg Surg 2022 05 27;17(1):28. Epub 2022 May 27.

Department of Emergency Medicine, Chang Gung Memorial Hospital, Chiayi, Taiwan.

Background: It remains unclear whether Vibrio vulnificus necrotizing soft tissue infection (NSTI) is associated with higher mortality compared with non-Vibrio NSTI. This study's objective was to compare outcomes including in-hospital mortality and prognosis between patients with V. vulnificus NSTI and those with non-Vibrio NSTI. Read More

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Characterization of Co-Stimulatory Ligand CD80/86 and Its Effect as a Molecular Adjuvant on DNA Vaccine Against in Flounder ().

Front Immunol 2022 10;13:881753. Epub 2022 May 10.

Laboratory of Pathology and Immunology of Aquatic Animals, Key Laboratory of Mariculture, Ministry of Education (KLMME), Ocean University of China, Qingdao, China.

The CD80/86 molecule is one of the important co-stimulatory ligands and involves antigen-specific immune responses by ligating with CD28 and then delivering the required second signal to T-cell activation. In this study, a CD80/86 homolog was identified, and its expression characteristics were studied in flounder (). The open reading frame (ORF) of is 906 bp, encoding 301 aa, and the extracellular amino acid sequence encoded two IgV- and IgC-like structural domains; is highly expressed in head kidney, peripheral blood leukocytes (PBLs), and spleen, and has relatively high expression in muscle. Read More

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Application of the Child Health and Nutrition Research Initiative (CHNRI) methodology to prioritize research to enable the implementation of Ending Cholera: A global roadmap to 2030.

PLoS One 2022 26;17(5):e0264952. Epub 2022 May 26.

Independent consultant (Retired World Health Organization staff), Geneva, Switzerland.

Background: The "Ending Cholera: A Global Roadmap to 2030" (Roadmap) was launched in October 2017. Following its launch, it became clear that additional evidence is needed to assist countries in controlling cholera and that a prioritized list of research questions is required to focus the limited resources to address the issues most relevant to the implementation of the Roadmap.

Methods: A comprehensive list of research questions was developed based on inputs from the Working Groups of the Global Taskforce for Cholera Control and other experts. Read More

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Dynamic mapping of cholera outbreak during the Yemeni Civil War, 2016-2019.

J Public Health Policy 2022 Jun 25;43(2):185-202. Epub 2022 May 25.

Nutrition Epidemiology and Data Science Division, Tufts University Friedman School of Nutrition Science and Policy, 150 Harrison Avenue, Boston, MA, 02111, USA.

Widespread destruction from the Yemeni Civil War (2014-present) triggered the world's largest cholera outbreak. We compiled a comprehensive health dataset and created dynamic maps to demonstrate spatiotemporal changes in cholera infections and war conflicts. We aligned and merged daily, weekly, and monthly epidemiological bulletins of confirmed cholera infections and daily conflict events and fatality records to create a dataset of weekly time series for Yemen at the governorate level (subnational regions administered by governors) from 4 January 2016 through 29 December 2019. Read More

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Assessing the Activity of Antimicrobial Peptides Against Common Marine Bacteria Located in Rotifer (Brachionus plicatilis) Cultures.

Probiotics Antimicrob Proteins 2022 May 25. Epub 2022 May 25.

Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, WA, Australia.

Rotifers are used as the first feed for marine fish larvae and are grown in large cultures that have high loads of organic matter and heterotrophic bacteria; these bacteria are passed on to the developing fish larvae and can potentially lead to bacterial infections. A modified minimum inhibitory concentration (MIC) protocol for antimicrobial peptides was used to determine the potency of ten antimicrobial peptides (AMPs) in artificial seawater relevant to a rotifer culture (salinity of 25‰) against common marine pathogens. All of the AMPs had antimicrobial activity against the bacterial isolates when the salt concentration was approximately zero. Read More

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Travel vaccines are strongly associated to reduced mortality in prostate cancer patients - a real effect or residual confounding?

Vaccine 2022 Jun 21;40(27):3797-3801. Epub 2022 May 21.

Department of Urology, Karolinska University Hospital Solna, Stockholm, Sweden; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. Electronic address:

Repurposing of existing drugs and vaccines for diseases that they were not originally intended for is a promising research field. Recently there has been evidence that oral cholera vaccine might be used in the treatment of inflammatory disease and some common cancers. Specifically, Ji et al showed that the administration of cholera vaccine after a prostate cancer diagnosis reduced prostate cancer specific mortality rates by almost 50%. Read More

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New Variant of Vibrio parahaemolyticus, Sequence Type 3, Serotype O10:K4, China, 2020.

Emerg Infect Dis 2022 06;28(6):1261-1264

In 2020, a new serotype of Vibrio parahaemolyticus O10:K4 emerged and caused several outbreaks and sporadic cases in Guangxi, China. Phylogenetic analysis indicated that those strains are new variants of the sequence type 3 pandemic clone. The new serotype may become dominant, warranting enhanced investigations and surveillance. Read More

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Outbreak of Imported Seventh Pandemic Vibrio cholerae O1 El Tor, Algeria, 2018.

Emerg Infect Dis 2022 06;28(6):1241-1245

After a lull of >20 years, Algeria experienced a cholera outbreak in 2018 that included 291 suspected cases. We found that outbreak isolates were Vibrio cholerae O1 serotype Ogawa from seventh pandemic El Tor sublineage AFR14, which corresponds to a new introduction of cholera into Africa from South Asia. Read More

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First record of isolation and characterization of Vibrio sinaloensis from diseased orange-spotted grouper Epinephelus coioides.

Dis Aquat Organ 2022 May 24;149:71-76. Epub 2022 May 24.

Tianjin Key Lab of Aqua-Ecology and Aquaculture, Fisheries College, Tianjin Agricultural University, Tianjin 300380, PR China.

A dominant bacterium, ZYL-12, isolated from the liver of a diseased orange-spotted grouper Epinephelus coioides, was identified as Vibrio sinaloensis, based on phenotypic and molecular analysis. The median lethal dosage of ZYL-12 was calculated as 1.6 × 105 CFU g-1 fish weight. Read More

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Inadequate Hand Washing, Lack of Clean Drinking Water and Latrines as Major Determinants of Cholera Outbreak in Somali Region, Ethiopia in 2019.

Front Public Health 2022 6;10:845057. Epub 2022 May 6.

School of Public Health, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia.

Introduction: Cholera remains a serious public health problem characterized by a large disease burden, frequent outbreaks, persistent endemicity, and high mortality, particularly in tropical and subtropical low-income countries including Ethiopia. The recent cholera outbreak in the Somali region began on 4 September to 1 November 2019. Cholera may spread rapidly through a population so that an early detection and reporting of the cases is mandatory. Read More

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A Global Perspective of Species and Associated Diseases: Three-Decade Meta-Synthesis of Research Advancement.

Environ Health Insights 2022 18;16:11786302221099406. Epub 2022 May 18.

SA-MRC Microbial Water Quality Monitoring Centre, University of Fort Hare, Alice, South Africa.

Outbreaks of infections have a long history of global public health concern and threat to the aquaculture industry. This 3-decade (1990-2019) meta-synthesis of global research progress in species and associated disease outbreaks was undertaken to generate the knowledge needed to design effective interventions with policy implications. Using PRISMA protocol, we obtained data on the online version of the Institute for Scientific Information (ISI), Web of Science (WOS), and Scopus from January 1990 to September 2021 by title search of the keywords " species OR spp. Read More

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[Etiological and epidemiological characteristics of in Beijing, 2015-2021].

Zhonghua Liu Xing Bing Xue Za Zhi 2022 May;43(5):734-738

Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing 100013, China.

To analyze the etiological and epidemiological characteristics of in Beijing during 2015-2021 and provide evidence for the prevention and control of cholera. The strains isolated in Beijing during 2015-2021 were analyzed by serotyping and virulence genes detection. Pulsed field gel electrophoresis (PFGE) was performed for the molecular typing of the strains. Read More

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Molecular characterization, antiviral activity, and UV-B damage responses of Caspase-9 from Amphiprion clarkii.

Fish Shellfish Immunol 2022 Jun 16;125:247-257. Epub 2022 May 16.

Department of Marine Life Sciences & Fish Vaccine Research Center, Jeju National University, Jeju, 63243, Republic of Korea; Marine Science Institute, Jeju National University, Jeju, 63333, Republic of Korea. Electronic address:

Apoptosis plays a vital role in maintaining cellular homeostasis in multicellular organisms. Caspase-9 (casp-9) is one of the major initiator caspases that induces apoptosis by activating downstream intrinsic apoptosis pathway genes. Here, we isolated the cDNA sequence (1992 bp) of caspase-9 from Amphiprion clarkii (Accasp-9) that consists of a 1305 bp coding region and encodes a 434 aa protein. Read More

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