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Acta Otorhinolaryngol Ital 2020 Feb;40(1):19-25

ENT Division, University of Eastern Piedmont, Novara, Italy.

Vestn Otorinolaringol 2019 ;84(6):33-37

N.I. Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Moscow, Russia, 117997.

Aim: The aim of this study is to evaluate clinical symptoms and recovery of vestibule-ocular reflex (VOR) in patients with vestibular neuronitis (VN) in dependence on severity of VOR damage according to video head impulse test (vHIT).

Patients And Methods: 45 patients with VN and superior or both superior and inferior vestibular nerves involvement were recruited and horizontal gain was measured with vHIT. According to gain asymmetry the patients were divided in three groups: 11 patients with 8-19% gain asymmetry, 10 patients with 20-39% gain asymmetry and 24 patients with more than 40% gain asymmetry. Read More

Arch Acad Emerg Med 2020 28;8(1):e3. Epub 2019 Dec 28.

Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Introduction: Differentiating central vertigo from peripheral ones poses a challenge to specialists. The present study aimed to examine the potential screening value of S100B and neuron-specific enolase (NSE) in this regard.

Methods: This prospective cross-sectional study recruited adult acute vertigo patients with suspected central causes visiting the emergency department (ED) in the first six hours since the onset of symptoms. Read More

J Int Med Res 2019 Dec 29:300060519892370. Epub 2019 Dec 29.

Department of Otolaryngology-Head and Neck Surgery, Anadolu Medical Center, Gebze, Kocaeli, Turkey.

Zh Nevrol Psikhiatr Im S S Korsakova 2019 ;119(9. Vyp. 2):85-89

Russian Medical Aacademy for Contuning Postgraduate Education, Moscow, Russia.

The development of peripheral vestibular disorders are often thought to be associated with vascular mechanisms, taking into account terminal type of inner ear blood supply and other predisposing factors. A number of studies indicates a high frequency of vascular risk factors in the patients with vestibular neuronitis and benign paroxysmal positional vertigo (BPPV). According to other results, migraine is widely spread among patients with Meniere's disease and BPPV. Read More

Otol Neurotol 2020 01;41(1):142-143

Department of Neurosurgery University of Illinois, College of Medicine at Peoria, Peoria IL.

Otol Neurotol 2020 01;41(1):143

Department of Otolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Acta Otorhinolaryngol Ital 2019 Oct;39(5):298-307

Surgical Sciences Department, University of Turin, Italy.

PLoS One 2019 31;14(10):e0224605. Epub 2019 Oct 31.

Department of Otorhinolaryngology-Head & Neck Surgery, Dankook University Hospital, Cheon-an, Republic of Korea.

In our previous study, we found that horizontal ocular deviation (OD) was significantly increased in patients with unilateral vestibular neuritis (VN). This study is aimed to compare the measurements of horizontal OD in various diseases which can present as acute vertigo in the emergency department. We retrospectively reviewed patients who visited the emergency department and underwent brain MRI due to acute vertigo. Read More

Tidsskr Nor Laegeforen 2019 10 2;139(14). Epub 2019 Oct 2.

Background: Acute dizziness may have a number of causes, including cerebrovascular stroke which can present as isolated acute vestibular syndrome. It is recommended that acute episodic dizziness be assessed using positioning tests, and acute persistent dizziness with a focus on the HINTS (Head Impulse, Nystagmus, Test of Skew) battery of tests, which can distinguish cerebrovascular stroke from vestibular neuritis. We wished to identify the prevalence, diagnostic spectrum and approach to acute dizziness in a neurological department. Read More

HNO 2020 May;68(5):324-335

Deutsches Schwindel- und Gleichgewichtszentrum (DSGZ), Klinikum der Universität München, LMU München, Marchioninistr. 15, 81377, München, Deutschland.

Background: Vestibular evoked myogenic potentials (VEMPs) are increasingly being used for testing otolith organ function.

Objective: This article provides an overview of the anatomical, biomechanical and neurophysiological principles of an evidence-based clinical application of ocular and cervical VEMPs (oVEMPs and cVEMPs).

Material And Methods: Systematic literature search in PubMed until April 2019. Read More

Eur Arch Otorhinolaryngol 2019 Dec 17;276(12):3309-3316. Epub 2019 Sep 17.

Service de radiologie 1, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.

Introduction: Vestibular neuritis is the second cause of vertigo and new imaging protocols using delayed FLAIR with double-dose of gadolinium are proposed for its diagnosis. Our aim is to demonstrate that a single dose of gadolinium is sufficient.

Methods: Thirty-three patients with a unilateral vestibular neuritis are compared to a control group. Read More

J Clin Neurosci 2019 12 16;70:269. Epub 2019 Aug 16.

University of Health Sciences, Kecioren Training and Research Hospital, Department of Internal Medicine, Ankara, Turkey.

Clin Neurophysiol 2019 09 31;130(9):1539-1556. Epub 2019 May 31.

Department of Neurology, University Hospital Zurich, University of Zurich, Switzerland.

Cervical and ocular vestibular evoked myogenic potentials (cVEMPs and oVEMPs respectively) are now used by an increasing number of laboratories to evaluate otolith inner ear function and their pathways through the central nervous system. However, the literature is incomplete or unclear as to what information both c- and oVEMPs can add beyond what a good clinical examination can provide, and what other paramedical tests can provide also, and the present review aims to clarify what is known so far. The following review will describe what is known with regards to both c- and oVEMPs and their use. Read More

J Vestib Res 2019;29(4):181-190

Epidemiology, IQVIA, Frankfurt, Germany.

Aim: The aim of this study was to analyze the demographic data pertaining to and seasonal variation in specific vestibular disorders in ear, nose, and throat (ENT) practices in Germany based on data from a representative nationwide practice database.

Method: The study sample included patients from 116 ENT practices in Germany who received an initial diagnosis (ICD-10 code) of Meniere's disease (MD, H81.0), benign paroxysmal positioning vertigo (BPPV, H81. Read More

Prog Brain Res 2019 23;248:241-248. Epub 2019 May 23.

Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy.

Objectives: The video head impulse test (vHIT) provides as output a gain value that summarizes the behavior of the vestibulo-ocular reflex as the ratio of a measure of eye movement to the corresponding measure of head movement and is not directly informative of the functional effectiveness of the motor response. The functional HIT (fHIT) is based on the ability to recognize the orientation of a Landolt C optotype that briefly appears on a computer screen during passive head impulses imposed by the examiner over a range of head accelerations; accordingly fHIT is a functional measurement of the vestibular-ocular reflex since it measures the capability to keep clear vision and to read during head movement.

Methods: We compared the results of the fHIT with those of the vHIT and the results of the Dizziness Handicap Inventory (DHI) questionnaire in a group of 27 vestibular neuritis patients recorded acutely and at 3-months follow-up. Read More

J Clin Neurosci 2019 Sep 13;67:134-138. Epub 2019 Jun 13.

Department of Otolaryngology, Erciyes University, Faculty of Medicine, Kayseri, Turkey.

Aim: To evaluate the alterations in inflammatory markers, NLR and PLR, as well as mean platelet volume (MPV) and the other parameters of complete blood counts (CBC) in adult patients with vestibular neuritis (VN).

Method: Designed as a case control study. The records of the patients, who were hospitalized due to an acute onset vertigo, and diagnosed as VN, were analysed retrospectively. Read More

Otol Neurotol 2019 07;40(6):701-709

Vestibular Genetics Laboratory, Boys Town National Research Hospital, Omaha, Nebraska.

Objective: In this review the authors discuss evidence from the literature concerning vitamin D and temporal bone diseases (benign paroxysmal positional vertigo [BPPV], Menière's disease [MD], vestibular neuritis, idiopathic facial paralysis, idiopathic acute hearing loss). Common features shared by Menière's disease, glaucoma, and the possible influence by vitamin D are briefly discussed.

Data Sources, Study Selection: Publications from 1970 until recent times have been reviewed according to a keyword search (see above) in PubMed. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jun;33(6):493-497

Vertigo Clinical Research Center of Aerospace, Air Force Specialty Medical Center of PLA, Beijing, 100142, China.

To explore the clinical effect of vestibular rehabilitation on vestibular neuritis. Fifty patients with vestibular neuritis (VN) were randomly divided into study group (=26) and control group (=24). The patient in study group received methylprednisolone treatment and peripheral vestibular rehabilitation therapy, while that in the control group received methylprednisolone only. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Jun;33(6):481-484

Department of Otolaryngology Head and Neck Surgery, the Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, 200233, China.

To explore composition and characteristics of vertigo in children. The diagnosis, medical history and examinations of 46 patients (≤17 years old) with vertigo were studied retrospectively. Of the 46 children patients with vertigo enrolled in this study, 19 patients were with BPVC(41. Read More

Med Biol Eng Comput 2019 Aug 4;57(8):1617-1627. Epub 2019 May 4.

Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Via Montpellier, 1; E sud Tower, 00133, Rome, Italy.

Since usefulness of power spectra (PS) analysis was demonstrated in many fields of electrophysiology, the aims of the present study were to evaluate differences in frequency domain values of eye velocity traces between a group of 60 healthy subjects (HC) and 35 matched superior vestibular neuritis (VN) patients and to determine prognostic aspects of such values in terms of superior VN recovery. PS calculated on video head impulse test traces was compared between HC and during the acute stage of vertigo (T1) and after 3 months (T2) in superior VN patients. A multiple regression and desirability model between Δ (T2gain - T1gain) vestibulo-ocular reflex (VOR) gain and five prognostic factors were employed. Read More

J Neurophysiol 2019 07 1;122(1):259-276. Epub 2019 May 1.

School of Biomedical Sciences and Pharmacy, The University of Newcastle and Hunter Medical Research Institute. Newcastle, New South Wales, Australia.

Older studies of mammalian otolith physiology have focused mainly on sustained responses to low-frequency (<50 Hz) or maintained linear acceleration. So the otoliths have been regarded as accelerometers. Thus evidence of otolithic activation and high-precision phase locking to high-frequency sound and vibration appears to be very unusual. Read More

Acta Otolaryngol 2019 Jun 29;139(6):511-516. Epub 2019 Apr 29.

a Department of Otorhinolaryngology-Head and Neck Surgery , Soonchunhyang University College of Medicine , Bucheon , Republic of Korea.

Background: Acute vestibular syndrome (AVS) is characterized by the rapid onset of vertigo, nausea, vomiting and gait unsteadiness, which lasts for days.

Aims/objectives: We report cases as acute vestibular asymmetry disorder (AVAD), with presentations that mimic vestibular neuritis (VN) but without central lesions.

Materials And Methods: We retrospectively reviewed records of patients presenting with acute spontaneous vertigo lasting more than 24 h from January 2011 to June 2016. Read More

Otol Neurotol 2019 07;40(6):797-805

Department of Otolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Objective: To analyze the clinical characteristics of acute vestibular neuritis (AVN) according to involvement site.

Study Design: Retrospective chart analysis.

Setting: Tertiary referral hospital. Read More

Adv Otorhinolaryngol 2019 15;82:87-92. Epub 2019 Jan 15.

Purpose of Chapter: This chapter highlights the recent advances in etiology, diagnostic evaluation, and management of vestibular neuritis (VN). Recent Findings: The viral hypothesis has been strengthened with new evidence as the main etiology of VN. Recent evidence indicates that bedside oculomotor findings play a critical role in differentiating VN from stroke. Read More

Exp Brain Res 2019 Jun 27;237(6):1531-1538. Epub 2019 Mar 27.

Ken and Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, 303 East Chicago Ave., Ward 12-140, Chicago, IL, 60611, USA.

Vestibular neuritis (VN) can affect utricular afferents. Utricular function can be assessed by ocular vestibular evoked myogenic potentials (oVEMPs) whose abnormalities include weak or absent responses, and ocular cycloposition whose abnormalities include ocular torsion (OT). When studied independently in vestibular neuritis, oVEMPs are abnormal in 61-82% of cases, and OT is present in 72-80% of cases. Read More

Otol Neurotol 2019 04;40(4):436-440

Faculty of Medicine, University of Paris 5, Paris, France.

Background: Tinnitus is frequently associated with a major hearing handicap, which has a significant impact on the quality of life of patients.

Aims: The goal was to analyze risk factors for tinnitus in patients followed in general practices in Germany.

Methods: Patients who had received a first tinnitus diagnosis in one of 928 general practices between January 2014 and December 2017 were included in this study. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Mar;33(3):220-224

Center of Vertigo Clinic Research of Aerospace, General Hospital of PLA Air Force, Beijing, 100142, China.

To analyze the clinical features of secondary benign paroxysmal positional vertigo (BPPV) and provide evidence for its precise diagnosis and treatment. There were 942 patients with vertigo related to BPPV, including 204 patients with primary BPPV, 592 patients with vestibular migraine (VM), 83 patients with Meniere's disease (MD), 48 patients with vestibular neuronitis (VN), and 15 patients with sudden sensorineural hearing loss (SSNHL) accompanied by vertigo.There were 127 patients with BPPV secondary to vertigo in MD, VN, VM, and SSNHL. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2019 Mar;33(3):216-219

Department of Otorhinolaryngology Head and Neck Surgery, Tianjin First Center Hospital, Otorhinolaryngology Institute of Tianjin, Tianjin, 300192, China.

To evaluate the frequency characteristics of semicircular canal injury in patients with vestibular neuritis. Fifty-three patients with vestibular neuritis were respectively evaluated by caloric test(CT)，head shaking test(HST),video head impulse test (vHIT),which reflects semicircular canal function in the low, middle, high frequency region. The asymmetric value of CT unilateral semicircular canal reaction (UW), head shaking nystagmus induced by HST, gain value of VHIT (VHIT-G) and presence or absence of saccade (VHIT-S) were used as observation indicators. Read More

Acta Otolaryngol 2019 Feb 15;139(2):135-145. Epub 2019 Feb 15.

a Peking University Aerospace School of Clinical Medicine , Beijing , P.R. China.

Objective: To evaluate the diagnostic value of eye movements and vestibular function tests in PCI patients.

Methods: Thirty-eight PCI patients and 31 patients with unilateral vestibular neuritis (UVN) were enrolled and underwent eye movement tests and vestibular function tests (spontaneous nystagmus [SN], head-shaking nystagmus [HSN]).

Results: The rates of eye movement abnormality were 78. Read More

Brain 2019 03;142(3):606-616

Academic Department of Neuro-Otology, Division of Brain Sciences, Charing Cross Hospital Campus, Imperial College London, Fulham Palace Road, London, UK.

Vestibular migraine is among the commonest causes of episodic vertigo. Chronically, patients with vestibular migraine develop abnormal responsiveness to both vestibular and visual stimuli characterized by heightened self-motion sensitivity and visually-induced dizziness. Yet, the neural mechanisms mediating such symptoms remain unknown. Read More

J Vestib Res 2018 ;28(5-6):417-424

Department of ENT, Audiology Unit, Faculty of Medicine, Mansoura University, Egypt.

Background: The management strategy for functional recovery after vestibular neuritis (VN) has not yet been established. Therapeutic choices involve corticosteroids, vestibular rehabilitation therapy (VRT) and the combination of corticosteroids with VRT.

Objective: The present study aimed to compare the efficacy of corticosteroids, vestibular rehabilitation, and combination of them in terms of subjective and objective improvement in patients with VN. Read More

Otol Neurotol 2019 03;40(3):372-374

Department of OtoRhinoLaryngology, Head and Neck Surgery, Clinical Sciences Lund University, Skåne University Hospital, Lund, Sweden.

Objective: To present findings that suggest steroid treatment within 24 hours of onset of vestibular neuronitis results in better restitution of vestibular function than treatment between 25 and 72 hours.

Patients: Thirty-three consecutive patients (17 men, 16 women, mean age 57 yr, range 17-85 yr) with acute vestibular neuronitis and treated with steroids within 72 hours after symptom onset. Patients were divided into two groups depending on if they were treated within the first 24 hours or not. Read More

Am J Otolaryngol 2019 Mar - Apr;40(2):319-322. Epub 2018 Dec 7.

ENT & Audiology Unit, Department of Experimental Diagnostic and Specialty Medicine (DIMES), S. Orsola - Malpighi University Hospital, Via Massarenti 9, 40138 Bologna, Italy.

Objectives: To describe a unique case of acute vertigo presenting with spontaneous horizontal nystagmus (SHN) and a clinical picture consistent with right acute peripheral vestibular loss (APVL) in which an isolated hypofunction of a horizontal semicircular canal (HSC) permitted to detect a spontaneous canalith jam and treat the patient accordingly.

Methods: Case report and literature review.

Results: A 74-year old woman presented with acute vertigo, left-beating SHN and a clinical picture consistent with right APVL. Read More

Otolaryngol Head Neck Surg 2019 05 22;160(5):894-901. Epub 2019 Jan 22.

1 Department of Otolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Objective: To analyze acute vertigo showing spontaneous nystagmus with negative video head impulse test (vHIT).

Study Design: Retrospective chart analysis.

Setting: Tertiary referral hospital. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;53(12):899-903

National Center for Children's Health of China, Department of Otorhinolaryngology Head and Neck Surgery, Beijing Children' s Hospital, Capital Medical University, Beijing Key Laboratory for Pediatric Diseases of Otolaryngology-Head and Neck Surgery, Beijing Pediatric Research Institute, Beijing 100045, China.

To investigate the clinical characteristics, prognosis and affected branches of vestibular neuritis in children. Twenty-five patients with vestibular neuritis in ENT department, Beijing Children's Hospital, from October 2015 to October 2016, were collected. All patients were 4-14 (mean 9. Read More

Curr Opin Neurol 2019 02;32(1):174-180

German Center for Vertigo and Balance Disorders.

Purpose Of Review: To review recent work on clinical and imaging aspects of vestibular neuritis (or acute vestibular syndrome), in particular with a view to identifying factors predicting long-term clinical outcome.

Recent Findings: Evidence for a role of inflammation in the vestibular nerve, and the presence of Gadolinium enhancement acutely in vestibular neuritis, is accruing. Visual dependence, anxiety and somatization traits predict the development of chronic dizziness after acute vestibular neuritis. Read More

Medicina (B Aires) 2018 ;78(6):410-416

Servicio de Otorrinolaringología, Hospital Británico de Buenos Aires, Argentina.

Vertigo is defined as an abnormal sensation of body motion or of its surrounding objects. It is a common chief complaint in emergency departments comprising 2 to 3% of these consultations worldwide. Vertigo is classified as peripheral or central, according to its origin, and can also be occasionally mixed, the most common cause of peripheral involvement being benign paroxysmal positional vertigo. Read More

Laryngoscope 2019 02 22;129(2):288-290. Epub 2018 Nov 22.

Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, Iowa, U.S.A.

J Neurol 2019 Jan 12;266(1):250-252. Epub 2018 Nov 12.

Department of Neurology, Seoul National University College of Medicine, Seoul, Republic of Korea.

Eur Radiol 2019 Jun 9;29(6):2760-2769. Epub 2018 Nov 9.

Department of Neuroradiology and MRI, Grenoble Alpes University Hospital - SFR RMN Neurosciences, Grenoble, France.

Purpose: 3D-FLAIR sequences with delayed acquisition after contrast medium injection have demonstrated new insights into blood-labyrinthine barrier (BLB) abnormalities in various diseases. The aim of this study was to assess the BLB in patients referred with unilateral acute vestibular syndrome (UAVS).

Materials And Methods: In this retrospective multicenter imaging study, we performed 3D-FLAIR and steady-state free precession (SSFP) sequences 4 h after contrast medium administration in 26 healthy volunteers and in 30 patients with UAVS. Read More

Neuroimage Clin 2018 9;20:1010-1017. Epub 2018 Oct 9.

Neuro-otology Unit, Division of Brain Sciences, Charing Cross Hospital, Imperial College London, London W6 8RP, UK. Electronic address:

Vestibular neuritis (VN) is characterised by acute vertigo due to a sudden loss of unilateral vestibular function. A considerable proportion of VN patients proceed to develop chronic symptoms of dizziness, including visually induced dizziness, specifically during head turns. Here we investigated whether the development of such poor clinical outcomes following VN, is associated with abnormal visuo-vestibular cortical processing. Read More

Otol Neurotol 2018 12;39(10):e1111-e1117

Department of Surgical Pathology, Medical, Molecular and Critical Area, ENT Section, University of Pisa, Pisa, Italy.

Objective: To assess, in patients referred to vestibular rehabilitation (VR) for persistence of disability after acute unilateral vestibulopathy (AUV), whether the video head impulse test (vHIT) can be a useful technique to define the efficacy of the treatment.

Study Design: Prospective clinical study.

Setting: Tertiary academic referral hospitals. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2018;118(8):38-42

Sechenov First Moscow State Medical University, Moscow, Russia.

Aim: To study the efficacy of various methods of non-drug therapy of diseases manifested by vertigo and dizziness in neurological practice.

Material And Methods: Referral and final diagnoses were compared after neurovestibular examination of 599 patients (177 men and 422 women), aged 25 to 79 years (mean age 55 years), with various causes of vertigo. Patients underwent vestibular rehabilitation, trainings on the stabiloplatform with biological feedback (biofeedback), repositioning maneuvers in patients with benign paroxysmal positional vertigo (BPPV). Read More

Am J Otolaryngol 2018 Nov - Dec;39(6):751-753. Epub 2018 Aug 29.

Department of Neurology, Ningbo No. 2 Hospital, Ningbo, Zhejiang 315010, PR China. Electronic address:

Purpose: To investigate the relationship between cerebrovascular risk factors, including carotid plaques, and vestibular neuritis (VN).

Materials And Methods: According to the inclusion and exclusion criteria, this retrospective study included 90 VN patients and 74 age- and sex-matched healthy controls from January 2016 to December 2017. All subjects' records of cerebrovascular risk factors, such as age, sex, height, weight, history of hypertension and diabetes mellitus, living habits, serum levels of glucose, lipids, glycosylated haemoglobin (HbA1c), creatinine (CR), albumin (ALB), haemoglobin (HGB); and results of carotid colour Doppler ultrasound, were obtained and compared. Read More

Otolaryngol Head Neck Surg 2018 10 31;159(4):603-607. Epub 2018 Aug 31.

12 Department of Neurology, University of Massachusetts Medical School-Baystate Health, Springfield, Massachusetts, USA.

Otol Neurotol 2018 10;39(9):e843-e848

Department of Neurosciences, Institute of Otolaryngology, Padova University, Padova, Italy.

Objective: Canalith jam refers to a condition caused by an otolithic clump blocked inside a semicircular canal, generally provoked by canalith repositioning procedure. We describe the first case of spontaneous canalith jam mimicking an acute vestibular deficit.

Patient: We report the case of an 82-year-old woman who suffered a sudden episode of persistent rotational vertigo with nausea and vomiting, not provoked by head movements. Read More

Otolaryngol Head Neck Surg 2018 08;159(2):400-401

Department of Otorhinolaryngology-Head and Neck Surgery, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.

Otolaryngol Head Neck Surg 2018 08;159(2):400

Safety Promotions and Injury Prevention Research Center and Department of Clinical Epidemiology, School of Public Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.