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Brain 2022 Apr;145(3):1139-1150

Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa 236-0004, Japan.

Cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS) is a late-onset, slow-progressing multisystem neurodegenerative disorder. Biallelic AAGGG repeat expansion in RFC1 has been identified as causative of this disease, and repeat conformation heterogeneity (ACAGG repeat) was also recently implied. To molecularly characterize this disease in Japanese patients with adult-onset ataxia, we accumulated and screened 212 candidate families by an integrated approach consisting of flanking PCR, repeat-primed PCR, Southern blotting and long-read sequencing using Sequel II, GridION or PromethION. Read More

Otolaryngol Head Neck Surg 2022 Mar 29:1945998221087664. Epub 2022 Mar 29.

Department of Otolaryngology-Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA.

Objective: To offer pragmatic, evidence-informed guidance on the use of systemic corticosteroids (SCS) for common otolaryngologic disorders.

Data Sources: PubMed, Cochrane Library, and American Academy of Otolaryngology-Head and Neck Surgery Foundation clinical practice guidelines.

Review Methods: A comprehensive search of published literature through November 2021 was conducted on the efficacy of SCS, alone or in combination with other treatments, for managing disorders in otolaryngology and the subdisciplines. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Mar;57(3):276-281

Department of Otorhinolaryngology Head and Neck Surgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Institute of Otology, School of Medicine, Shanghai Jiaotong University, Shanghai Key Laboratory of Ear and Nose Disease Transformation, Shanghai 200092, China.

To guide the patients with vertigo who are suitable for vestibular rehabilitation therapy (VRT), and to evaluate the curative effect through a remote guidance platform based on mobile internet. Adult outpatients, who were diagnosed as vestibular disorders and required VRT, were selected and conducted baseline evaluation and formulated vestibular rehabilitation plan according to their symptoms, diagnosis and vestibular function examination results. These patients downloaded and installed the mobile internet remote guidance platform app for VRT, and then registered and uploaded medical records. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Mar;57(3):270-275

Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

To explore the dynamic changes of vestibular autorotation test (VAT) before and after vestibular rehabilitation treatment in patients with unilateral vestibular hypofunction (UVH). A retrospective study was carried out,48 patients who were diagnosed with UVH and under vestibular rehabilitation in department of otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, from January 2019 to January 2021 were enrolled. Among them, there were 21 males and 27 females, with an average age of 46. Read More

J Pak Med Assoc 2022 Feb;72(2):354-356

Department of Otorhinolaryngology, Van Yuzuncu Yil University, Turkey.

In the present era of the coronavirus 2019 (COVID-19) pandemic, it has been observed that the severe acute respiratory syndrome, coronavirus 2 (SARS-CoV-2) infection does not only affect the respiratory tract, but also triggers various neurological symptoms in one-third of patients. The most prominent of such symptoms is anosmia, which is independent of rhinologic symptoms such as nasal obstruction, discharge, and pain that cannot be otherwise explained. Vestibular neuronitis ranks third among the causes of peripheral vestibular vertigo, characterized by nausea, vomiting, and dizziness that develops within minutes or hours. Read More

Eur Arch Otorhinolaryngol 2022 Jun 16;279(6):3211-3217. Epub 2022 Mar 16.

Department of ENT, Affiliated Hospital of Liaoning Traditional Chinese Medicine University, Shenyang, China.

Purpose: We aimed to study the results of the head impulse paradigm (HIMP) and the suppression head impulse paradigm (SHIMP) in patients with acute vestibular neuritis (AVN) to compare dizziness handicap inventory (DHI) scores before and after treatment. We also wanted to investigate the correlation between the HIMP, SHIMP and DHI score and to analyze the factors that affect the recovery with AVN in the short term.

Methods: The HIMP, SHIMP, and DHI score were assessed in 20 patients with AVN before (T) and after treatment (T). Read More

Ann Palliat Med 2022 Feb;11(2):480-489

Department of Otorhinolaryngology, Tianjin Medical University General Hospital, Tianjin, China.

Background: This study aimed to investigate the efficacy and safety of mecobalamin combined with vestibular rehabilitation training in acute vestibular neuritis and to improve the clinical therapeutic effect in vestibular nerve disease.

Methods: We performed a literature search of the PubMed, Medline, China National Knowledge Infrastructure (CNKI), and other databases from the date of establishment of the database until the present. The search terms included "mecobalamin", "vestibular rehabilitation training", "vestibular rehabilitation therapy", and "vestibular neuritis". Read More

J Laryngol Otol 2022 02;136(2):95-96

Neurology 2022 04 28;98(16):678-683. Epub 2022 Feb 28.

From the Department of Neurology (K.-T.K., S.-H.B., S.-U.L., J.B.K.), Korea University Medical Center; Department of Neurology (S.-U.L., J.-S.K.), Seoul National University College of Medicine; and Dizziness Center (J.-S.K.), Seoul National University Bundang Hospital, Seongnam, Republic of Korea.

We describe acute vestibular syndrome in a 48-year-old woman with breast cancer who was finally found to have anti-Ma2-associated encephalitis. Although the initial diagnosis was vestibular neuritis elsewhere, progression of symptoms and additional findings of bilateral ptosis and circumlimbal injections, vertical saccadic slowing, and impaired convergence led to a suspicion of a rostral midbrain lesion and final diagnosis. The patient's symptoms and ocular motor signs improved markedly after administration of IV methylprednisolone and oral tacrolimus. Read More

Cells 2022 02 16;11(4). Epub 2022 Feb 16.

Aix Marseille Université-CNRS, Laboratoire de Neurosciences Cognitives, LNC UMR 7291, 13331 Marseille, France.

Unilateral vestibular lesions induce a vestibular syndrome, which recovers over time due to vestibular compensation. The therapeutic effect of L-Thyroxine (L-T4) on vestibular compensation was investigated by behavioral testing and immunohistochemical analysis in a rat model of unilateral vestibular neurectomy (UVN). We demonstrated that a short-term L-T4 treatment reduced the vestibular syndrome and significantly promoted vestibular compensation. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Mar;36(3):217-221

Department of Otolaryngology，Beijing Rehabilitation Hospital，Capital Medical University，Beijing，100144，China.

To evaluate the efficacy of vestibular rehabilitation in patients with anterior peripheral vertigo and analyze its influencing factors. From January 2018 to June 2021, 153 cases with peripheral vertigo diseases（including 47 cases of benign positional paroxysmal vertigo, 38 cases of Meniere's disease, 26 cases of sudden deafness with vertigo, 23 cases of vestibular migraine and 19 cases of vestibular neuritis） were enrolled. One hundred and three cases were treated with vestibular rehabilitation combined with drugs, and 50 cases only treated with drugs were used as controls. Read More

Medicine (Baltimore) 2022 Jan;101(4):e28740

Department of Physical Therapy, The Graduate School of Sahmyook University, Seoul, Republic of Korea.

Abstract: Vestibular neuritis is a common disease of peripheral dizziness. Studies have shown that vestibular rehabilitation exercise (VRE) and proprioceptive neuromuscular facilitation (PNF) are effective to treat the symptoms of vestibular neuritis. However, the effect of VRE and PNF on the balance ability and dizziness in this patient cohort remains unclear. Read More

J Neurol Sci 2022 Mar 19;434:120159. Epub 2022 Jan 19.

Faculty of Medicine, University of Zurich, Zurich, Switzerland; Department of Neurology, University Hospital Zurich, Zurich, Switzerland; Department of Ophthalmology, University Hospital Zurich, Zurich, Switzerland; Clinical Neuroscience Center, Zurich, Switzerland.

Background Disorders affecting the vestibular organs (semicircular canals, utriculus, sacculus), may result in distinct patterns of peripheral-vestibular loss that may facilitate the diagnostic assessment. When neuropathological tests of these sensors are available, it is possible to classify responses as being due to different deficit types. Objective To provide a topical review and to summarize recent advances in pattern-recognition of unilateral and bilateral vestibular disease by use of hierarchical cluster analysis (HCA) as published by the authors. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(12. Vyp. 2):41-49

Pirogov National Medical and Surgical Center, Moscow, Russia.

The article discusses two main causes of acute vestibular dizziness - vertebrobasilar ischemic stroke and vestibular neuritis. The features of acute vestibular syndrome depending on the localization of cerebral infarction - in the territory of the posterior inferior, anterior inferior and superior cerebellar arteries, as well as in the brain stem are presented. Detailed clinical characteristics of vestibular neuritis is given. Read More

J Laryngol Otol 2022 Feb 10;136(2):129-136. Epub 2022 Jan 10.

Fondazione Santa Lucia Scientific Institute for Research and Healthcare, Rome, Italy.

Background: Studying otolith functions after unilateral vestibular neuritis using ocular vestibular-evoked myogenic potentials and subjective visual vertical tests could give different results.

Method: A total of 39 patients underwent a vestibular assessment that included the Dizziness Handicap Inventory and horizontal and vertical semicircular canal function testing with video head impulse testing, ocular vestibular-evoked myogenic potential testing, cervical vestibular-evoked myogenic potentials and subjective visual vertical testing.

Results: All patients showed a significant alteration (asymmetry ratio more than 40 per cent) for ocular vestibular-evoked myogenic potentials as well as for subjective visual vertical testing (more than -2° to more than +2°) during the acute phase, whereas after 72 hours from the acute vertigo attack normal values (asymmetry ratio less than 40 per cent) were found in 6 out of 39 patients for ocular vestibular-evoked myogenic potentials and 36 out of 39 for the subjective visual vertical (less than -2° to less than +2°). Read More

J Pers Med 2021 Dec 8;11(12). Epub 2021 Dec 8.

Department of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon 24253, Korea.

Headaches, especially migraines, have been associated with various vestibular symptoms and syndromes. Tinnitus and hearing loss have also been reported to be more prevalent among migraineurs. However, whether headaches, including migraine or non-migraine headaches (nMH), are associated with vestibular and cochlear disorders remains unclear. Read More

J Clin Med 2021 Dec 7;10(24). Epub 2021 Dec 7.

Division of Balance Disorders, Department of Otorhinolaryngology and Head and Neck Surgery, Maastricht University Medical Center, 6229 HX Maastricht, The Netherlands.

History taking is crucial in the diagnostic process for vestibular disorders. To facilitate the process, systems such as TiTrATE, SO STONED, and DISCOHAT have been used to describe the different paradigms; together, they address the most important aspects of history taking, viz. time course, triggers, and accompanying symptoms. Read More

Cells 2021 12 1;10(12). Epub 2021 Dec 1.

Aix-Marseille Université-CNRS, Laboratoire de Neurosciences Cognitives, LNC UMR 7291, Centre Saint-Charles Case C, 3 Place Victor Hugo, CEDEX 03, 13331 Marseille, France.

Acute peripheral vestibulopathy leads to a cascade of symptoms involving balance and gait disorders that are particularly disabling for vestibular patients. Vestibular rehabilitation protocols have proven to be effective in improving vestibular compensation in clinical practice. Yet, the underlying neurobiological correlates remain unknown. Read More

Hum Vaccin Immunother 2021 Dec 13;17(12):5126-5128. Epub 2021 Dec 13.

Department of Otorhinolaryngology, National Health Insurance Service Ilsan Hospital, Goyang, Korea.

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 and presents with pneumonia as the most frequent and serious manifestation. COVID-19 vaccination is an important and urgent interest globally due to COVID-19's rapid spread and high rates of mortality and morbidity. Vestibular neuritis (VN) is an acute vestibular syndrome that causes acute and spontaneous vertigo due to unilateral vestibular deafferentiation, leading to nausea or vomiting and unsteadiness that can last from days to weeks. Read More

Curr Opin Neurol 2022 02;35(1):64-74

Central Clinical School, Faculty of Medicine and Health, University of Sydney.

Purpose Of Review: To most neurologists, assessing the patient with vertigo is an unpleasant and worrisome task. A structured history and focused examination can be complemented by carefully selected laboratory tests, to reach an early and accurate diagnosis. We provide evidence-based recommendations for vestibular test selection. Read More

Acta Otorhinolaryngol Ital 2021 Oct;41(5):401-409

University Clinic of Otorhinolaryngology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

Sci Rep 2021 11 3;11(1):21579. Epub 2021 Nov 3.

Department of Physical Medicine & Rehabilitation, Eulji University Uijeongbu Hospital, Dongil-ro, 712, Uijeongbu-si, Gyeonggi-do, Republic of Korea.

Although symptoms of unilateral vestibular neuritis (uVN) resolve spontaneously within several weeks, recovery of gait function has unclearness in gait parameter changes and mediolateral stability improvements. In addition, prospective longitudinal studies on gait parameters after uVN are lacking. This study was conducted to reveal longitudinal change of gait function after acute uVN and to help the precise rehabilitation planning. Read More

Acta Med Port 2021 Jun 1;34(6):428-434. Epub 2021 Jun 1.

Serviço de Otorrinolaringologia e Cirurgia Cérvico-facial. Hospital de Braga. Braga. Portugal.

Introduction: Vestibular disorders in pediatric patients is still a controversial subject but has gained relevance over the years. In recent studies, its prevalence varied between 0.7% and 15%. Read More

Clin Otolaryngol 2022 01 4;47(1):34-43. Epub 2021 Nov 4.

Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Objectives: The present meta-analysis sought to assess further evidence for the efficacy of steroids in vestibular neuritis (VN).

Methods: The PubMed, EMBASE and Cochrane Library databases were searched through 30 August 2019. The main outcome measure was dizziness handicap inventory (DHI) and secondary outcomes included complete caloric recovery and improvement of canal paresis (CP). Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Sep;35(9):802-806

Department of Otolaryngology Head and Neck Surgery，the Second Xiangya Hospital，Central South University，Changsha，410011，China.

To investigate interrelationships in parameters between caloric test and video head impulse test（vHIT） in the common peripheral vertigo diseases and healthy people, and to conduct correlation and difference analysis between the results in two tests, so as to evaluate the clinical diagnosis value of peripheral vertigo. The caloric test and vHIT were fulfilled in 68 patients with vertigo and 17 healthy volunteers. The diagnosis was done according to history inquiring, otology and audiology examination and vestibular tests. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Oct;35(10):905-909

The Third District，Department of Neurology，the First People's Hospital of Chenzhou City，Chenzhou，423000，China.

〓 Objective: To analyze the clinical characteristics of patients with benign paroxysmal positional vertigo, summarize experience for diagnosis and treatment activities and to explore the risk factors related to the onset of BPPV and provide reference for early intervention to reduce the risk factor exposure of BPPV. One hundred and twelve patients with BPPV were included in the study, and clinical data including age, gender, onset symptoms and duration, past medical history and family history were analyzed. A One-way ANOVA was performed on 16 variables using age, gender, diabetes, hyperuric acid, hyperlipidemia, osteoporosis, hypertension, coronary heart disease, stroke, Meniere's disease, suppurative otitis media, vestibular neuronitis, sudden deafness, head injury, ear nose/maxillofacial surgery and autoimmune thyroiditis. Read More

J Int Adv Otol 2021 Sep;17(5):433-437

Fondazione Santa Lucia IRCCS, Rome, Italy.

Objective: To evaluate the presence of anti-compensatory saccades (AcS) using the video head impulse test (vHIT) in the healthy inner ear in patients with vestibular neuritis (VN) during the acute and subacute stages of VN.

Methods: We retrospectively considered a chart review of 2420 patients evaluated for acute vestibular syndrome from 2016 to 2020 in the Cassino (Italy) clinic. Nine hundred fifty-four patients with acute onset of vestibular syndrome who received an instrumental otoneurological assessment within 24 hours from the onset of the symptoms, evaluated by simultaneously using a combination of vHIT, ocular vestibular-evoked myogenic potential (VEMP), and cervical VEMP, were included in the study. Read More

Am J Otolaryngol 2022 Jan-Feb;43(1):103203. Epub 2021 Sep 11.

Cureus 2021 Aug 12;13(8):e17121. Epub 2021 Aug 12.

Medicine, Services Hospital, Lahore, PAK.

Since the declaration of coronavirus disease 2019 (COVID-19) as a pandemic, it remains a widespread infection with a major impact on global resources and health infrastructure. The hallmark of COVID-19 continues to be the well-documented effects it has on the respiratory system. With the passage of time, the involvement of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus in other systems has become more apparent, with the increased incidence of thromboembolic events, cardiac involvement as well as gastrointestinal and neurological symptoms secondary to the infection. Read More

Am J Otolaryngol 2022 Jan-Feb;43(1):103202. Epub 2021 Sep 9.

Coimbra University Hospital Centre, Department of Neurology, Praceta Professor Mota Pinto, 3000-075 Coimbra, Portugal. Electronic address: