9,962 results match your criteria Vesicoureteral Reflux


Parental Preferences for Vesicoureteral Reflux Treatment: a Crowd-sourced, Best-worst Scaling Study.

Urology 2019 Mar 13. Epub 2019 Mar 13.

Division of Urology, Duke University Medical Center, Durham, NC. Electronic address:

Objective: To quantitatively evaluate parental preferences for the various treatments for vesicoureteral reflux using crowd-sourced best-worst scaling, a novel technique in urologic preference estimation.

Methods: Preference data were collected from a community sample of parents via two best-worst scaling survey instruments published to Amazon's Mechanical Turk online community. Attributes and attribute levels were selected following extensive review of the reflux literature. Read More

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http://dx.doi.org/10.1016/j.urology.2019.01.045DOI Listing

Can we predict vesicoureteral reflux resolution in patients with non-neurogenic lower urinary tract dysfunction?

Int J Urol 2019 Mar 14. Epub 2019 Mar 14.

Department of Urology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Objective: To analyze factors influencing reflux resolution in patients with the coexistence of non-neurogenic lower urinary tract dysfunction and vesicoureteral reflux.

Methods: The data of 153 children who were diagnosed with vesicoureteral reflux and accompanying non-neurogenic lower urinary tract dysfunction between 2010 and 2015 were retrospectively evaluated. Patients with neurogenic and anatomical malformations, monosymptomatic nocturnal enuresis, previous history of vesicoureteral reflux surgery, irregular and/or incomplete follow-up data were excluded. Read More

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http://dx.doi.org/10.1111/iju.13946DOI Listing

Role of Late DMSA Renal Scan in Detecting High-Grade Vesicoureteral Reflux.

Indian J Pediatr 2019 Mar 11. Epub 2019 Mar 11.

Nephrology Unit, Hospital General de Niños Pedro de Elizalde, Montes de Oca 40, CP 1270, Ciudad Autónoma de Buenos Aires, Argentina.

Objective: To determine the performance of late dimercaptosuccinic acid (DMSA) renal scans in identifying high-grade (III-V) vesicoureteral reflux (VUR) in children aged over 3 y with a febrile urinary tract infection (fUTI) history that has not been timely investigated.

Methods: In this retrospective study of diagnostic accuracy, the clinical records of children aged between 3 and 18 y with fUTI history evaluated consecutively at Nephrology Unit of Hospital General de Niños Pedro de Elizalde, Argentina between 2006 and 2016 were reviewed. Patients with previously diagnosed renal or urinary tract abnormalities or who underwent previous postnatal genitourinary imaging were excluded. Read More

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http://dx.doi.org/10.1007/s12098-019-02917-4DOI Listing

Usefulness of the classification of urinary dysfunction for the prognosis of the first endoscopic treatment of vesicoureteral reflux in children over the age of 3.

Actas Urol Esp 2019 Mar 1. Epub 2019 Mar 1.

Sección de Urología Infantil, Servicio de Urología, Hospital Universitari i Politècnic La Fe, Valencia, España.

Objectives: To assess the diagnostic performance of urinary dysfunction patterns associated with vesicoureteral reflux (VUR) in children over the age of 3 according to the result of the first endoscopic treatment (ENDT1), grouped into a classification designed by our group (CMD.URI-La Fe). Comparison with other current classifications such as that of Van Batavia et al. Read More

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http://dx.doi.org/10.1016/j.acuro.2018.06.005DOI Listing
March 2019
1 Read

[Empyema in Left Ureteral Stump Following Bilateral Nephrectomy and Living Renal Transplant-Case Report].

Hinyokika Kiyo 2019 Jan;65(1):19-22

The Department of Urology, Hyogo Prefectural Nishinomiya Hospital.

A 34-year-old male came to us with congenital spina bifida, vesicoureteral reflux and scoliosis. He had been on hemodialysis for chronic renal failure caused by reflux nephropathy since the age of 23 years. At the age of 24, he received bilateral nephrectomy and underwent living renal transplantation from his mother. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_65_1_19DOI Listing
January 2019
1 Read

Nineteen-month-old girl with persistent fever.

Arch Dis Child Educ Pract Ed 2019 Feb 23. Epub 2019 Feb 23.

Pediatric Hematology Unit, Department of Woman, Child and of General and Specialized Surgery, Università degli Studi della Campania, Naples, Italy.

CASE REPORT: A 19-month-old girl with right fourth-degree vesicoureteral reflux and left small non-functional kidney was admitted with a 6-day 39°C fever. She was receiving antibiotic prophylaxis (amoxicillin-clavulanate) for urinary tract infections (UTIs). At admission, she had been taking ciprofloxacin for 2 days due to leucocyturia and nitrites shown by the urine dipstick without urine culture test being done. Read More

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http://dx.doi.org/10.1136/archdischild-2018-316493DOI Listing
February 2019
1 Read

Urinary excretion of pentraxin-3 correlates with the presence of renal scar following acute pyelonephritis in children.

Int Urol Nephrol 2019 Feb 22. Epub 2019 Feb 22.

Department of Biochemistry, Pamukkale University School of Medicine, 20070, Kınıklı Yerleşkesi/Denizli, Turkey.

Purpose: Acute pyelonephritis is associated with considerable morbidity and potential for renal scarring. Pentraxin3 (PTX3) is a recently discovered mediator of inflammation. The objective of this study was to investigate the changes in serum and urine PTX3 levels in children who had a history of pyelonephritis and were diagnosed with renal parenchymal scar (RPS) and/or vesicoureteral reflux (VUR). Read More

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http://dx.doi.org/10.1007/s11255-019-02102-8DOI Listing
February 2019
1 Read

2018 Update on Pediatric Medical Overuse: A Review.

JAMA Pediatr 2019 Feb 18. Epub 2019 Feb 18.

Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California.

Importance: Efforts to combat medical overuse have gained traction in recent years, but success has been intermittent and shortcomings have been recognized. A commitment to a strong evidence base is needed to more broadly engage clinicians and reduce overuse.

Observations: A structured MEDLINE search and a manual review of tables of contents from selected high-impact journals was performed to identify original research published in 2017 relevant to pediatric overuse. Read More

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http://dx.doi.org/10.1001/jamapediatrics.2018.5550DOI Listing
February 2019
1 Read

Coexisting sources of false positive reflux on a direct radionuclide cystography scan.

J Nucl Med Technol 2019 Feb 15. Epub 2019 Feb 15.

Department of Nuclear Medicine, Taleghani Educational Hospital, School of Medicine, Shahid Beheshti, Iran, Islamic Republic of.

Direct radionuclide cystography (DRC) is currently a popular method for evaluation of vesicoureteral reflux (VUR), in spite of its pitfalls and drawbacks in producing false positive results. In this article, it is intended to present a case with two sources of false positive reflux on a DRC scan. Read More

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http://dx.doi.org/10.2967/jnmt.118.222075DOI Listing
February 2019
1 Read

Prospective evaluation of the management of bowel dysfunction in children with neuropathic lower urinary tract dysfunction and its effect on bladder dynamics.

J Pediatr Surg 2019 Jan 22. Epub 2019 Jan 22.

Department of Urology, Faculty of medicine, University of Alexandria, Egypt.

Introduction And Aim: Children with neuropathic lower urinary tract dysfunction usually suffer from associated bowel dysfunction, urinary tract infection and vesicoureteral reflux. This work aimed to highlight the impact of bowel management on bladder dynamics.

Patients And Methods: In the period from January 2011 to January 2013, 30 patients, 21 girls and 9 boys with neuropathic lower urinary tract dysfunction were studied. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2018.12.015DOI Listing
January 2019
1 Read

Outcome of posterior urethral valve in 64 children. Single center experience of 22 years.

Minerva Urol Nefrol 2019 Feb 14. Epub 2019 Feb 14.

Department of Pediatric Nephrology, Faculty of Medicine, Kocaeli University, Kocaeli, Turchia.

Background: Posterior urethral valve (PUV) is the most serious form of congenital anomalies of kidney and urinary tract (CAKUT) in boys with significant risk of progression to chronic kidney disease (CKD). We present our long term results in children with PUV.

Methods: Retrospective chart review of 113 children with PUV followed within the years of 1996-2018 was performed. Read More

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http://dx.doi.org/10.23736/S0393-2249.19.03272-7DOI Listing
February 2019
4 Reads
0.700 Impact Factor

New trends in voiding cystourethrography and vesicoureteral reflux: Who, when and how?

Int J Urol 2019 Feb 14. Epub 2019 Feb 14.

Department of Urology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.

Vesicoureteral reflux, retrograde flow of urine from the bladder into the upper urinary tract, is one of the most common urological diagnoses in the pediatric population. Diagnosis and subsequent management of urinary reflux have become increasingly debated in the past decade, with divergent opinions over which patients should be evaluated for reflux, and when detected, which children should receive intervention. Although some argue that vesicoureteral reflux is a "phenotype" that often resolves without intervention, others contest that untreated reflux has the potential to cause irreversible renal damage over time. Read More

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http://doi.wiley.com/10.1111/iju.13915
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http://dx.doi.org/10.1111/iju.13915DOI Listing
February 2019
6 Reads

Endoscopic Management of Vesicoureteral Reflux and Long-term Follow-up.

Indian Pediatr 2018 Dec;55(12):1046-1049

Department of Nuclear Medicine, PGIMER, Chandigarh, India.

Objective: To report our experience with endoscopic management of vesicoureteral reflux (VUR) by injection of a tissue bulking substance - Dextranomer/ hyaluronic acid co-polymer at vesicoureteric junction.

Design: Retrospective analyses of case records.

Setting: Pediatric Surgery department in a tertiary care government Institute. Read More

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December 2018
2 Reads

Current Perspectives in Management of Vesicoureteral Reflux.

Indian Pediatr 2018 12;55(12):1039-1040

Department of Pediatric Nephrology, Madhukar Rainbow Children Hospital, Delhi, India.

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December 2018
1 Read
1.014 Impact Factor

Evaluation of cyclic direct radionuclide cystography findings with DMSA scintigraphy results in children with a prior diagnosis of vesicoureteral reflux.

Nucl Med Commun 2019 Feb 7. Epub 2019 Feb 7.

Department of Nuclear Medicine, Adana Teaching and Medical Research Center, Faculty of Medicine, Baskent University, Ankara, Turkey.

Objectives: Direct radionuclide cystography (DRC) with cyclic imaging is a sensitive method used for the detection of vesicoureteral reflux (VUR). Radionuclide cystography is generally recommended for follow-up evaluation of VUR. The aim of this study was to evaluate cyclic DRC with DMSA scan results during the follow-up period in children with a prior diagnosis of VUR. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000994DOI Listing
February 2019
1 Read

[Clinical usefulness of the non-invasive functional study of the lower urinary tract voiding phase as a predictor of resolution after the first endoscopic treatment of vesico-ureteral reflux in children older than 3 years.]

Arch Esp Urol 2019 Jan;72(1):36-44

Sección de Urología Infantil. Servicio de Urología. Hospital Universitari i Politècnic La Fe. Valencia. España.

Objectives: To determine the usefulnessof voiding diary (VD), uroflowmetry with electromyography(UF-EMG), bladder wall thickness (before micturition)(VWTUS) and residual urine (PVR) (ultrasound measure)in predicting the outcome of the first endoscopic treatment(1ENDT) of vesicoureteral reflux (VUR) in children> 3 years.

Methods: Cross-sectional ambispective study of 48children with vesicoureteral reflux. Those with previousendoscopic treatment, age or neurological abnormalities and a history of urethralor abdominal surgery were excluded. Read More

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January 2019
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Predictors of Renal Dysfunction in Adults with Childhood Vesicoureteral Reflux after Long-Term Follow-Up.

Open Access Maced J Med Sci 2019 Jan 14;7(1):107-113. Epub 2019 Jan 14.

University Clinic of Cardiology, Medical School, University Ss. Cyril and Methodius of Skopje, Skopje, Republic of Macedonia.

Background: Triad of childhood vesicoureteral reflux (VUR), urinary infection (UTI) and renal scarring might initiate potentially serious consequences that lead to renal dysfunction manifested at the second or third decade of life.

Aim: To identify the risk factors predictive for renal dysfunction in adults with primary VUR after long-term follow-up.

Methods: We evaluated the records of 101 children (94. Read More

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http://dx.doi.org/10.3889/oamjms.2019.078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352487PMC
January 2019
1 Read

Adherence to the 2011 American Academy of Pediatrics Urinary Tract Infection Guidelines for Voiding Cystourethrogram Ordering by Clinician Specialty.

Urology 2019 Feb 6. Epub 2019 Feb 6.

Department of Urology, Northwestern University, Chicago, IL; Division of Pediatric Urology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL. Electronic address:

Objective: To evaluate rates of guideline adherence and associations with voiding cystourethrogram result. The American Academy of Pediatrics guidelines recommend voiding cystourethrogram after abnormal renal ultrasound or 2 febrile urinary tract infections. It is unclear whether guideline adherence increases vesicoureteral reflux detection. Read More

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http://dx.doi.org/10.1016/j.urology.2018.12.044DOI Listing
February 2019
2 Reads

Baseline Urinary Tract Imaging in Infants Enrolled in the UMPIRE Protocol for Children with Spina Bifida.

J Urol 2019 Feb 5:101097JU0000000000000141. Epub 2019 Feb 5.

Division of General Pediatrics, Children's Hospital Los Angeles , Los Angeles , California.

Purpose: The lifetime risk of renal damage in children with spina bifida is high but only limited baseline imaging data are available for this population. We evaluated a large prospective cohort of infants with spina bifida to define their baseline imaging characteristics.

Materials And Methods: The UMPIRE Protocol for Young Children with Spina Bifida is an iterative quality improvement protocol that follows a cohort of newborns at 9 United States centers. Read More

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http://dx.doi.org/10.1097/JU.0000000000000141DOI Listing
February 2019
2 Reads

Population-based trend analysis of voiding cystourethrogram ordering practices in a single-payer healthcare system before and after the release of evaluation guidelines.

J Pediatr Urol 2019 Jan 3. Epub 2019 Jan 3.

Division of Urology, The Hospital for Sick Children and Department of Surgery, University of Toronto, Canada. Electronic address:

Introduction: While voiding cystourethrogram (VCUG) is a widely-accepted test, it is invasive and associated with radiation exposure. Most cases of primary vesicoureteral reflux (VUR) are low-grade and unlikely to be associated with acquired renal scarring. To select patients at greatest risk, in 2011 the American Academy of Pediatrics (AAP) published guidelines for evaluation of children ages 2 - 24 months with urinary tract infections (UTIs). Read More

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http://dx.doi.org/10.1016/j.jpurol.2018.12.009DOI Listing
January 2019
5 Reads

A Modified Transurethral Stenting Technique for (Robot-Assisted) Laparoscopic Ureteral Reimplantation.

Urol Int 2019 Feb 1:1-5. Epub 2019 Feb 1.

Department of Urinary Surgery, The Seventh Medical Center of PLA General Hospital, Beijing, China.

Background: Ureteral stenting is a technique-demanding procedure performed during robot-assisted laparoscopic ureteral reimplantation (RALUR). Many stenting techniques have been reported; however, none of them could be accepted as an ideal way.

Objectives: The aim of the study was to report our initial results of a modified stenting technique for RALUR. Read More

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https://www.karger.com/Article/FullText/496470
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http://dx.doi.org/10.1159/000496470DOI Listing
February 2019
2 Reads

Renal tubular markers as screening tools for severe vesicoureteral reflux.

Eur J Pediatr 2019 Jan 31. Epub 2019 Jan 31.

Pediatric Nephrology Division, University of Florida, Gainesville, FL, USA.

Severe (grades IV and V) vesicoureteral reflux (VUR) is a risk factor for acute pyelonephritis, renal scars, and renal failure. This study evaluates albumin and N-acetylglucosaminidase (NAG) urinary excretion, and renal concentrating ability as screening tools to select patients for voiding cystourethrogram (VCUG). Children (111 M, 52 F) aged 10. Read More

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http://dx.doi.org/10.1007/s00431-019-03324-9DOI Listing
January 2019
1 Read

Graft Survival in Patients With Lower Urinary Tract Dysfunction.

Exp Clin Transplant 2019 Jan 31. Epub 2019 Jan 31.

From the Department of Pediatric Nephrology, Akdeniz University, School of Medicine, Antalya, Turkey.

Objectives: We aimed to the determine urinary tract infection and graft survival rates in pediatric renal transplant recipients with lower urinary tract dysfunction with particular focus on neurogenic bladder, posterior urethral valve, and vesicoureteral reflux nephropathy.

Materials And Methods: Patients were grouped according to primary diseases as those with and without lower urinary tract dysfunction. Urinary tract infections during year 1 posttransplant were investigated. Read More

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http://dx.doi.org/10.6002/ect.2018.0029DOI Listing
January 2019
1 Read

The role of bladder function in the pathogenesis and treatment of urinary tract infections in toilet-trained children.

Pediatr Nephrol 2019 Jan 22. Epub 2019 Jan 22.

Division of Urology, Hospital for Sick Children and Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

Urinary tract infections (UTIs) are a common reason for referral to pediatric specialists and the risk profile of these children is influenced by age, sex, and underlying urinary tract abnormalities. UTIs in toilet-trained children represent a different entity than confirmed, febrile UTIs that occur in infants, impacted by suboptimal bladder habits, bladder dysfunction, constipation, or a combination of these factors. A comprehensive literature search was conducted using PubMed and MEDLINE and search terms included recurrent UTI, VUR, bladder and bowel dysfunction (BBD), constipation, lower urinary tract symptoms, and voiding dysfunction. Read More

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http://dx.doi.org/10.1007/s00467-019-4193-6DOI Listing
January 2019
6 Reads

Vitamin A supplementation is effective for improving the clinical symptoms of urinary tract infections and reducing renal scarring in girls with acute pyelonephritis: a randomized, double-blind placebo-controlled, clinical trial study.

Complement Ther Med 2019 Feb 12;42:429-437. Epub 2018 Dec 12.

Neurology and Neuroscience Research Center, Qom University of Medical Sciences, Qom, Iran.

Introduction: It is believed that tubulointerstitial inflammation plays a role in the formation of renal scarring secondary to acute pyelonephritis (APN). Vitamin A is an anti-inflammatory agent that is involved in the re-epithelialization of damaged mucosal surfaces.

Objective: The aim of this study was to evaluate the efficacy of vitamin A supplementation in combination with antibiotics for improving urinary tract infections (UTIs) symptoms and preventing renal scarring in girls with APN. Read More

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http://dx.doi.org/10.1016/j.ctim.2018.12.007DOI Listing
February 2019
1 Read
2.216 Impact Factor

Videolaparoscopic lower pole heminephrectomy for treatment of a duplex kidney.

J Pediatr Urol 2018 Nov 22. Epub 2018 Nov 22.

Pediatric Urology Department, Fundació Puigvert, Barcelona, Spain. Electronic address:

Introduction: In a duplicated renal collecting system, or duplex kidney, the most frequent pathology presenting at the lower pole is the vesicoureteral reflux (VUR), which could lead to urinary tract infections (UTI) or even renal dysplasia. Under some circumstances, such as recurrent UTIs or impaired kidney function, heminephrectomy of the pathologic moiety is indicated. However, there are only few academic videos of laparoscopic lower pole heminephrectomy in the pediatric population available in literature. Read More

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http://dx.doi.org/10.1016/j.jpurol.2018.11.009DOI Listing
November 2018
4 Reads

Minimally-Invasive Ureteral Reconstruction for Ureteral Complications of Kidney Transplants.

Urology 2019 Jan 14. Epub 2019 Jan 14.

Lahey Hospital & Medical Center, Burlington, MA.

Objective: To present the technique, feasibility and results of minimally-invasive reconstruction of the transplanted ureter using the native ipsilateral ureter in post-transplant ureteral strictures and vesicoureteral reflux (VUR) causing graft pyelonephritis. Ureteral complications after kidney transplantation represent a significant cause of morbidity potentially leading to graft dysfunction or loss.

Methods: A prospective database from October 2011 to August 2018 identified renal transplant recipients who underwent minimally-invasive pyeloureterostomies or ureteroureterostomies using the ipsilateral ureter. Read More

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http://dx.doi.org/10.1016/j.urology.2019.01.002DOI Listing
January 2019
2 Reads

[Instillation therapies for urothelial carcinoma of the upper urinary tract].

Urologe A 2019 Jan;58(1):25-29

Urologische Universitätsklinik, Inselspital, Universitätsspital Bern, 3010, Bern, Schweiz.

Traditionally, urothelial carcinoma of the upper urinary tract was a clear indication for radical nephroureterectomy with bladder cuff excision. It has been shown that in well-selected patients and depending on tumor stage, a kidney-sparing approach can be pursued with good oncological outcome and equivalent to the radical approach. The prevention of local and bladder recurrences is an important factor. Read More

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http://link.springer.com/10.1007/s00120-018-0830-0
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http://dx.doi.org/10.1007/s00120-018-0830-0DOI Listing
January 2019
6 Reads

Managing vesicoureteral reflux in children: making sense of all the data.

F1000Res 2019 8;8. Epub 2019 Jan 8.

Children's Health System Texas, University of Texas Southwestern, Dallas, TX, USA.

Current management of vesicoureteral reflux (VUR) in children is the result of a steady albeit controversial evolution of data and thinking related to the clinical impact of VUR and urinary tract infection (UTI) in children, the value of clinical screening, and the relative impact of testing and interventions for VUR. While controversy continues, there is consensus on the importance of bladder dysfunction on VUR outcomes, the likelihood of VUR resolution, and the fact that not all children with VUR require active treatment. Early efforts to define risk stratification hold the most promise to provide more patient-specific treatment of UTI and VUR in children. Read More

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https://f1000research.com/articles/8-29/v1
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http://dx.doi.org/10.12688/f1000research.16534.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329208PMC
January 2019
6 Reads

Integration of Genetic Testing and Pathology for the Diagnosis of Adults with FSGS.

Clin J Am Soc Nephrol 2019 Jan 15. Epub 2019 Jan 15.

Division of Nephrology and

Background And Objectives: FSGS and nephrotic syndrome studies have shown that single gene causes are more likely to be found in pediatric cases than adults. Consequently, many studies have examined limited gene panels in largely pediatric cohorts.

Design, Setting, Participants, & Measurements: Whole-exome sequencing was performed in adults with FSGS diagnosed between 1976 and 2017 in the Toronto GN Registry. Read More

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http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.08750718
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http://dx.doi.org/10.2215/CJN.08750718DOI Listing
January 2019
12 Reads

Value of Renal Pelvic Diameter and UTD classification in Prediction of Urinary Tract Anomalies.

Pediatr Int 2019 Jan 13. Epub 2019 Jan 13.

Dr. Sami, Ulus Maternity and Child Health and Diseases Training and Research Hospital, Department of Pediatric Nephrology, Ankara.

Background: In this study, we aimed to identify the cut-off values of postnatal anteroposterior renal pelvic diameter (APRPD) and we present our data based on the Urinary Tract Dilation (UTD) classification system to identify the predictors for final diagnosis of urinary tract dilation and the need for surgery.

Methods: A total of 260 infants (336 renal units) with prenatally detected urinary tract dilation were prospectively evaluated with serial ultrasonography by the same radiologist. Additional radiological assessments with voiding cystourethrography and scintigraphy were done according to our clinical algorithm. Read More

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http://dx.doi.org/10.1111/ped.13788DOI Listing
January 2019
2 Reads

[High ureteral insertion as the cause of extreme hydronephrosis in a 5-year-old child with horseshoe kidney].

Dev Period Med 2018 ;22(4):371-375

Katedra i Klinika Pediatrii i Nefrologii, Warszawski Uniwersytet Medyczny, Polska.

The incidence of horseshoe kidney is 1 per 400-800 live births. From 44-52% of the patients with horseshoe kidney have other coexisting abnormalities of the urinary tract, such as hydronephrosis, vesicoureteral reflux and a duplex collecting system. Our patient, a 5-year old boy, was admitted to a pediatric nephrology department because of abdominal pain and vomiting. Read More

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January 2018
7 Reads

Gen1 Modulates Metanephric Morphology Through Retinoic Acid Signaling.

DNA Cell Biol 2019 Mar 11;38(3):263-271. Epub 2019 Jan 11.

1 Department of Nephrology, Children's Hospital of Fudan University, Shanghai Kidney Development and Pediatric Kidney Disease Research Center, Shanghai, China.

Congenital anomalies of the kidney and urinary tract (CAKUT) are the leading cause of end-stage renal disease in children. Our group has discovered that Holliday Junction resolvase gene Gen1 is a potential candidate gene for CAKUT. Gen1 mutant mice showed CAKUT phenotypes similar to those observed in retinoic acid (RA)-deficient models. Read More

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http://dx.doi.org/10.1089/dna.2018.4426DOI Listing
March 2019
1 Read

Extravesical Ureteral Reimplantation Following Lich-Gregoir Technique for the Correction of Vesico-Ureteral Reflux Retrospective Comparative Study Open vs. Laparoscopy.

Front Pediatr 2018 18;6:388. Epub 2018 Dec 18.

Department of Pediatric Surgery and Urology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

The aim is to compare the outcome of open versus laparoscopic Lich-Gregoir technique in patients with vesicoureteral reflux. We report a retrospective multicenter comparative study between open and laparoscopic extra-vesical ureteral reimplantation (EVUR) following Lich-Gregoir (LG) technique for the correction of Vesico-Ureteral Reflux (VUR). Between January 2007 and December 2015, 96 patients with VUR (69 females and 27 males) and deterioration of the renal function, underwent EVUR following LG technique. Read More

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https://www.frontiersin.org/article/10.3389/fped.2018.00388/
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http://dx.doi.org/10.3389/fped.2018.00388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305429PMC
December 2018
2 Reads

The evaluation of vesicoureteral reflux among children using contrast-enhanced ultrasound: a literature review.

J Pediatr Urol 2019 Feb 20;15(1):12-17. Epub 2018 Nov 20.

Department of Radiology, Instituto da Criança, University of São Paulo Medical School, São Paulo, Brazil. Electronic address:

Introduction: Voiding cystourethrogram (VCUG) with fluoroscopy remains the gold standard for detection and evaluation of vesicoureteral reflux (VUR) among children. However, the ionizing radiation exposure remains a concern for this diagnostic modality. Recent studies have proposed using contrast-enhanced ultrasound as an alternative option for VUR screening and follow-up in children. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14775131183067
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http://dx.doi.org/10.1016/j.jpurol.2018.11.006DOI Listing
February 2019
4 Reads

Transurethral incision as initial option in treatment guidelines for ectopic ureteroceles associated with duplex systems.

World J Urol 2019 Jan 2. Epub 2019 Jan 2.

Department of Urology and Urological Science Institute, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Republic of Korea.

Purpose: Treatment strategies for children with ectopic ureteroceles (EUs) and duplex collecting systems or vesicoureteral reflux are controversial. Transurethral incision (TUI) of EUs associated with duplex systems has been considered only as a temporizing technique. This study aimed to evaluate whether primary TUIs could be considered as an initial treatment option in EUs with duplex systems. Read More

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http://dx.doi.org/10.1007/s00345-018-2607-xDOI Listing
January 2019
4 Reads

Outcomes of kidney transplants in pediatric patients with the vertebral defects, anal atresia, cardiac defects, tracheoesophageal fistula, renal anomalies, limb abnormalities association.

Pediatr Transplant 2019 03 30;23(2):e13341. Epub 2018 Dec 30.

Division of Nephrology, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.

In this single-center retrospective study, we analyzed kidney transplant outcomes in nine pediatric patients with VACTERL [vertebral defects, anal atresia, cardiac defects, tracheoesophageal fistula, renal anomalies, limb abnormalities] association-making this the largest study of its kind. Of 743 pediatric kidney transplant recipients at our center (1980-2017), nine had documented diagnoses of VACTERL association. All nine had congenital anorectal malformations and renal anomalies, five had vertebral defects, and one had a bifid thumb and tracheoesophageal fistula. Read More

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http://dx.doi.org/10.1111/petr.13341DOI Listing
March 2019
3 Reads

Susceptibility patterns of uropathogens identified in hospitalized children.

Pediatr Int 2018 Dec 28. Epub 2018 Dec 28.

Department of Pediatrics, Venizeleion General Hospital, Heraklion, Crete, Greece.

Background: Urinary tract infection (UTI) is the most common serious bacterial infection in childhood. The aim of the present study was therefore to identify the organisms responsible for community-acquired febrile UTI in children, to investigate their susceptibility to commonly used antibiotics, and to identify possible risk factors for antibiotic resistance.

Methods: A total of 284 children (male, 38%; female, 62%), who were hospitalized due to a community-acquired UTI over a 5 year period in a general district hospital of southern Greece, were enrolled in the study. Read More

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http://doi.wiley.com/10.1111/ped.13772
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http://dx.doi.org/10.1111/ped.13772DOI Listing
December 2018
12 Reads
0.731 Impact Factor

Predictors of grade 3-5 vesicoureteral reflux in infants ≤ 2 months of age with pyelonephritis.

Pediatr Nephrol 2018 Dec 26. Epub 2018 Dec 26.

Department of Pediatrics, Assaf Harofeh Medical Center, 70300, Zerifin, Israel.

Background: This study aimed to assess predictors for grade 3-5 vesicoureteral reflux (VUR) in infants ≤ 2 months of age admitted for first urinary tract infection (UTI).

Methods: Retrospective cohort study of 195 infants ≤ 2 months admitted to a pediatric ward for first UTI between 2006 and 2017. Clinical, laboratory, and imaging data were collected from electronic medical charts. Read More

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http://dx.doi.org/10.1007/s00467-018-4167-0DOI Listing
December 2018
1 Read

The copy number variation landscape of congenital anomalies of the kidney and urinary tract.

Nat Genet 2019 Jan 21;51(1):117-127. Epub 2018 Dec 21.

Division of Nephrology, Department of Medicine, Columbia University, New York, NY, USA.

Congenital anomalies of the kidney and urinary tract (CAKUT) are a major cause of pediatric kidney failure. We performed a genome-wide analysis of copy number variants (CNVs) in 2,824 cases and 21,498 controls. Affected individuals carried a significant burden of rare exonic (that is, affecting coding regions) CNVs and were enriched for known genomic disorders (GD). Read More

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http://www.nature.com/articles/s41588-018-0281-y
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http://dx.doi.org/10.1038/s41588-018-0281-yDOI Listing
January 2019
16 Reads

Externalized Percutaneous Stent Versus Internal Double J Stent: Short- and Long-term Complications After Kidney Transplantation.

Transplant Proc 2018 Dec 18;50(10):3416-3421. Epub 2018 Apr 18.

Department of Visceral Surgery and Medicine, University Hospital, Bern, Switzerland. Electronic address:

Background: In patients undergoing kidney transplantation, ureteral stents are an established technique to reduce major urologic complications such as leakage and stenosis of the ureter. However, the best technique for ureteral stenting remains unclear. The aim of this study was to compare the outcome of percutaneous ureteral stents (PS) with internal double J stents (JJS) after kidney transplantation. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.04.042DOI Listing
December 2018
1 Read

Ureteral dilatation detected in magnetic resonance imaging predicts vesicoureteral reflux in children with urinary tract infection.

PLoS One 2018 21;13(12):e0209595. Epub 2018 Dec 21.

Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Objective: Urinary tract infection (UTI), one of the most common bacterial infections occurring during infancy and early childhood, is frequently associated with vesicoureteral reflux (VUR). Although several guidelines recommend performing ultrasonography as a screening test, its utility is not adequate and appropriate screening tests are strongly desirable. In this study, we evaluate the use of magnetic resonance imaging (MRI) as a screening test for VUR in children with UTI. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209595PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303055PMC
December 2018
1 Read

Detection of Vesicoureteral Reflux using Electrical Impedance Tomography.

IEEE Trans Biomed Eng 2018 Dec 14. Epub 2018 Dec 14.

Objective: The purpose of this study is to detect vesicoureteral reflux (VUR) non-invasively using electrical impedance tomography (EIT). VUR is characterized by the backflow of urine from the bladder to the kidneys.

Methods: Using porcine models, small quantities of a solution mimicking the electrical properties of urine were infused into each ureter. Read More

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http://dx.doi.org/10.1109/TBME.2018.2886830DOI Listing
December 2018
3 Reads

Pediatric voiding cystourethrography: An essential examination for urologists but a terrible experience for children.

Int J Urol 2019 02 19;26(2):160-171. Epub 2018 Dec 19.

Department of Urology, Shiga University of Medical Science, Otsu, Shiga, Japan.

Voiding cystourethrography is the most important fluoroscopic examination in pediatric urology for the investigation of lower urogenital tract diseases, such as vesicoureteral reflux or urethral stricture. However, this invasive procedure imposes a significant burden on children and their parents, and recently there has been a paradigm shift in the diagnosis and treatment of vesicoureteral reflux. In the 2011 revision, the American Academy of Pediatrics guidelines on urinary tract infection recommended abandoning routine voiding cystourethrography after the first febrile urinary tract infection. Read More

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http://dx.doi.org/10.1111/iju.13881DOI Listing
February 2019
1 Read

Expert opinion: art of endoscopic injection therapy for primary pediatric vesicoureteral reflux.

Authors:
Angela M Arlen

J Pediatr Urol 2018 Dec 12;14(6):590. Epub 2018 Nov 12.

Department of Urology, Yale School of Medicine, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jpurol.2018.10.030DOI Listing
December 2018
2 Reads

CEVL interactive: Art of endoscopic injection therapy for primary pediatric vesicoureteral reflux.

Authors:
A Kirsch M Maizels

J Pediatr Urol 2018 Dec 12;14(6):585-588. Epub 2018 Nov 12.

Ann and Robert H. Lurie Children's Hospital of Chicago, IL Northwestern University Feinberg School of Medicine, Chicago, IL, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14775131183067
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http://dx.doi.org/10.1016/j.jpurol.2018.11.002DOI Listing
December 2018
14 Reads

Diagnostic accuracy of contrast-enhanced voiding urosonogram using second-generation contrast with harmonic imaging (CEVUS-HI) study for assessment of vesicoureteral reflux in children: a meta-analysis.

World J Urol 2018 Dec 12. Epub 2018 Dec 12.

Section of Pediatric Imaging, Institute of Radiology, St. Luke's Medical Center, Quezon City, NCR, Philippines.

Purpose: To assess the diagnostic accuracy and safety of contrast-enhanced voiding urosonogram using second-generation contrast with harmonic imaging (CEVUS-HI) in detecting vesicoureteral reflux (VUR) among children.

Methods: A systematic literature search was performed in March 2018. Relevant comparative studies from Medline, EMBASE, World of Science, Scopus, CENTRAL, WHO trial registry and Clinicaltrials. Read More

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http://link.springer.com/10.1007/s00345-018-2587-x
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http://dx.doi.org/10.1007/s00345-018-2587-xDOI Listing
December 2018
2 Reads