Search Our Scientific Publications & Authors

Cureus 2019 Jan 25;11(1):e3961. Epub 2019 Jan 25.

Internal Medicine, Oak Hill Hospital, Brooksville, USA.

Supra-aortic atherosclerotic lesions, including innominate artery atheromas, are an uncommon but established cause of transient ischemic attacks, stroke, upper extremity ischemia, and vertebrobasilar insufficiency. We present a patient with a transient ischemic attack admitted with right hemispheric symptoms who was found to have a severe ulcerated innominate artery atheroma. The patient underwent an aortic arch angiogram with stenting of the innominate artery. Read More

Front Neurol 2019 19;10:215. Epub 2019 Mar 19.

Department of Neurology, Severance Stroke Center, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

Endovascular treatment (EVT) for acute vertebrobasilar intracranial atherosclerosis-related large vessel occlusion (ICAS-LVO) and its outcomes are not well known. We aimed to evaluate endovascular and clinical outcomes of vertebrobasilar ICAS-LVO patients who underwent EVT. Consecutive acute stroke patients who underwent EVT for vertebrobasilar LVO were retrospectively reviewed. Read More

World Neurosurg 2019 Mar 26. Epub 2019 Mar 26.

Neurorestoration Center, Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA USA. Electronic address:

Background: Vertebrobasilar insufficiency (VBI) is associated with high rates of morbidity and mortality, especially after failure of first-line medical and/or endovascular therapies. While the optimal therapeutic strategy for refractory VBI remains unclear, surgical bypass represents a potentially life-saving treatment in this patient subset.

Methods: A multi-institution retrospective database review was performed to identify patients with symptomatic refractory VBI over a four-year period (7/2014 to 7/2018). Read More

Medicine (Baltimore) 2019 Mar;98(13):e14899

Department of Neurology, The Second Affiliated Hospital of Soochow University, No. 1055, Sanxiang Road, Suzhou, Jiangsu 215000, China.

This study aimed to compare the clinical efficacy of stenting compared with standardized medical treatment in patients with moderate to severe vertebral artery origin stenosis (VAOS).Patients diagnosed with moderate to severe VAOS and indicated to undergo vertebral artery stenting were enrolled. Patients were divided into stenting group and standardized medical treatment group. Read More

Front Neurol 2019 13;10:207. Epub 2019 Mar 13.

Abteilung für Neuroradiologie, Universitätsklinikum Leipzig, Leipzig, Germany.

Ruptured dissecting aneurysms of the intracranial vertebral arteries exhibit an extraordinarily high risk for morbidity and mortality and are prone to re-rupture. Therefore, early treatment is mandatory to induce stagnation of the critical dynamic mural process. Appropriate endovascular approaches are segment sacrifice and reconstruction, however, both carry specific risks and benefits. Read More

Stroke 2019 Apr;50(4):859-866

Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA (F.Z., Z.F., B.Z., Z.D., D.D., D.S.B., D.L., Y.X.).

Background and Purpose- Cervicocerebral vascular calcification on computed tomography angiography is a known sign of advanced atherosclerosis. However, the clinical significance of calcification pattern remains unclear. In this study, we aimed to investigate the potential association between spotty calcium and acute ischemic stroke. Read More

World Neurosurg 2019 Mar 8. Epub 2019 Mar 8.

Department of Neurosurgery, Fukuoka University Chikushi Hospital, Chikushino-city, Japan.

Background: Cranial artery dolichoectasia (CADE) is characterized by dilated, elongated, and tortuous cranial arteries. Dolichoectasia and dolichoectatic aneurysm-particularly of the internal carotid arteries (ICAs)-is rare, but can lead to stroke. We report a case of suspected recurrent acute cerebral infarction associated and dolichoectatic aneurysm of the left ICA combined with right dolichoectatic aneurysm, vertebrobasilar dolichoectasia, and atrial fibrillation. Read More

J Clin Neurosci 2019 May 6;63:17-21. Epub 2019 Mar 6.

Department of Neurology, Xinqiao Hospital & the Second Affiliated Hospital, the Army (Third Military) Medical University, Chongqing, China. Electronic address:

This retrospective study is to investigate the safety and efficacy of the stent implanting for treating severe symptomatic atherosclerotic stenosis of the intracranial vertebrobasilar artery (ICVBA). 213 patients who had undergone intervention for severe symptomatic ICVBA stenosis between September 2012 to May 2018 were enrolled into this study. Among the 213 enrolled patients, 210 patients (98. Read More

Laryngoscope 2019 Mar 1. Epub 2019 Mar 1.

Department of Otolaryngology-Head and Neck Surgery, Oregon Health and Science University, Portland, Oregon, U.S.A.

We describe the diagnostic workup and surgical treatment of a patient presenting with the unique case of vertebral artery (VA) occlusion subsequent to head flexion leading to compression of an aberrant VA by the ipsilateral superior cornu of the thyroid cartilage. Imaging revealed ischemic infarcts as well as the presence of an aberrant right VA, which was compressed by the ipsilateral superior cornu of the thyroid cartilage upon neck flexion. The patient was managed with laryngoplasty involving removal of the right superior cornu of the thyroid cartilage. Read More

Cerebrovasc Dis 2019 15;47(1-2):48-56. Epub 2019 Feb 15.

Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany,

Background And Purpose: Renal dysfunction (RD) is overall associated with unfavorable functional outcome and higher risk of mortality after acute ischemic stroke. Associations between RD and outcome in patients with acute vertebrobasilar stroke treated with thrombectomy have not been evaluated so far.

Materials And Methods: Consecutive patients with vertebrobasilar stroke treated with mechanical thrombectomy between October 2010 and July 2017 at our center were analyzed. Read More

Cerebrovasc Dis 2019 14;47(1-2):40-47. Epub 2019 Feb 14.

College of Medicine, China Medical University, Taichung, Taiwan.

Background: The natural history of vertebrobasilar artery (VBA) stenosis or occlusion remains understudied.

Methods: Patients with diagnosis of ischemic stroke or transient ischemic attack (TIA) who were noted to have VBA stenosis based on computed tomography or magnetic resonance imaging or catheter-based angiogram were selected from Taiwan Stroke Registry. Cox proportional hazards model was used to determine the hazards ratio (HR) of recurrent stroke and death within 1 year of index event in various groups based on severity of VBA stenosis (none to mild: 0-49%; moderate to severe: 50-99%: occlusion: 100%) after adjusting for differences in demographic and clinical characteristics between groups at baseline evaluation. Read More

Arq Neuropsiquiatr 2019 Jan;77(1):25-32

Universidade Federal de Santa Maria, Departamento de Fonoaudiologia, Santa Maria, RS, Brasil.

Objective: Changes in postural balance and visual complaints are frequent consequences of stroke. We aimed to investigate the symptoms and the vestibular and oculomotor functions of patients with dizziness post ischemic and hemorrhagic stroke and compare the results among them.

Methods: Fifty patients with dizziness after stroke were evaluated through a clinical anamnesis and computerized vector electronystagmography: calibration of ocular movements, spontaneous nystagmus, semi-spontaneous nystagmus, pendular tracking, optokinetic nystagmus, rotary chair testing, and the caloric test. Read More

J Vasc Interv Neurol 2018 Nov;10(2):56-58

Servicio de Neurología del Hospital Universitario Dr. José Eleuterio González de la Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.

Background And Purpose: Cervical artery dissections, which may be traumatic or spontaneous, account for a significant proportion of strokes in the young. Antithrombotic therapy is the mainstay of treatment, but new oral anticoagulants could be an alternative treatment to the optimal strategy of anticoagulation followed by antiplatelet drugs.

Summary Of Case: We report the case of a 40-year-old patient with a spontaneous vertebral artery dissection who developed a cerebellar ischemic stroke, who had a favorable outcome and complete vessel recanalization after three months of treatment with the oral factor Xa inhibitor rivaroxaban. Read More

J Vasc Interv Neurol 2018 Nov;10(2):28-32

Department of Neurosurgery, University of Patras, Patras, Greece.

Background: Hereditary multiple exostoses (HME) is an inherited genetic condition, characterized by the formation of multiple osteochondromas, developing throughout childhood and into puberty. Vascular complications associated with HME are uncommon.

Methods: A case of a patient with HME who was admitted to hospital with subarachnoid hemorrhage (SAH), as a result of acute rupture of a basilar tip aneurysm (BTA), will be presented. Read More

Front Neurol 2018 21;9:1195. Epub 2019 Jan 21.

Department of Neurology, Ajou University Medical Center, Ajou University School of Medicine, Suwon, South Korea.

Differentiation of embolic and atherosclerotic occlusions is difficult prior to endovascular treatment (EVT) of acute ischemic stroke due to intracranial large artery occlusions. CTA-determined occlusion type has been reported to be associated with a negative cardiac embolic source and stent retriever failure, a potential of intracranial atherosclerosis (ICAS)-related occlusions. In this study, we evaluated the agreement between preprocedural identification of CTA-determined truncal-type occlusion (TTO) and postprocedural evaluation of underlying fixed focal stenosis (FFS) in the occlusion site. Read More

Surg Radiol Anat 2019 Feb 7. Epub 2019 Feb 7.

Department of Neurology, Yokohama Brain and Spine Center, 1-2-1 Takigashira, Isogo-ku, Yokohama, 235-0012, Japan.

We report a case of an anomalous anastomosis formed between the external carotid artery (ECA) and the vertebrobasilar artery (VBA) and passing through the hypoglossal canal. A carotid-vertebrobasilar anastomosis of this kind is typically considered a variant of persistent primitive hypoglossal artery which usually originates from the internal carotid artery. However, the anastomotic vessel in this case had a common trunk with the occipital artery (OA), a remnant of the primitive proatlantal artery. Read More

Neurosurg Focus 2019 Feb;46(2):E8

1Department of Neurosurgery, Peking University First Hospital; and.

OBJECTIVESymptomatic steno-occlusion of the proximal vertebral artery (VA) or subclavian artery (ScA) heralds a poor prognosis and high risk of stroke recurrence despite medical therapy, including antiplatelet or anticoagulant drugs. In some cases, the V2 segment of the cervical VA is patent and perfused via collateral vessels. The authors describe 7 patients who were successfully treated by external carotid artery (ECA)-saphenous vein (SV)-VA bypass. Read More

Oxf Med Case Reports 2019 Jan 24;2019(1):omy121. Epub 2019 Jan 24.

Department of Neurosurgery, Uonuma Institute of Community Medicine, Niigata University Medical and Dental Hospital, Niigata, Japan.

In this report, we describe unilateral medial pontomedullary junction (MPMJ) syndrome as a novel brain stem stroke syndrome. A 68-year-old woman suddenly developed vertigo, ipsilateral facial paresis, contralateral thermal hypoalgesia (TH) and dysphagia without lateral gaze palsy, curtain sign and hoarseness. Magnetic resonance (MR) imaging showed a small infarction at the right MPMJ. Read More

BMC Neurol 2019 Jan 29;19(1):14. Epub 2019 Jan 29.

Department of Neurology, Faculty of Medicine, University of Debrecen, Moricz Zs. krt 22, Debrecen, 4032, Hungary.

Background: The signs and symptoms of acute alcohol intoxication resemble those of vertebrobasilar stroke. Due to their shared symptoms including double vision, nystagmus, dysarthria, and ataxia, the differential diagnosis of alcohol intoxication and vertebrobasilar stroke may pose a challenge. Moreover, if alcohol intoxication and stroke occur simultaneously, the signs and symptoms of stroke may be attributed to the effects of alcohol, leading to delayed stroke diagnosis and failure to perform reperfusion therapy. Read More

J Stroke Cerebrovasc Dis 2019 Apr 14;28(4):e24-e26. Epub 2019 Jan 14.

Division of Neurology, Department of Internal Medicine, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.

Fatalities following intravenous recombinant tissue-type plasminogen activator therapy have been reported. Major fatal complications following intravenous recombinant tissue-type plasminogen activator therapy include intracranial hemorrhage, aortic dissection, and extracranial bleeding. However, the possibility that intravenous recombinant tissue-type plasminogen activator therapy itself paradoxically induces synchronized multiple cerebral novel infarctions has never been considered. Read More

World J Clin Cases 2019 Jan;7(1):73-78

Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

Background: Millard-Gubler syndrome (MGS) is caused by a lesion in the brainstem at the level of the facial nerve nucleus, and it is also a rare ventral pontine syndrome. Vertebrobasilar artery dissection (VAD) is an uncommon cause of ischemic stroke. To the best of our knowledge, this is the first case report on the coexistence of MGS and VAD in a young acute ischemic stroke patient. Read More

World Neurosurg 2019 Jan 3. Epub 2019 Jan 3.

Department of Neurosurgery, Washington University, St. Louis, Missouri, USA; Mallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri, USA; Department of Neurology, Washington University, St. Louis, Missouri, USA.

Background: The Pipeline Embolization Device (PED) has been increasingly used for the treatment of posterior circulation aneurysms. The purpose of the present study was to examine the clinical and angiographic outcomes of patients with vertebrobasilar aneurysms treated with the PED.

Methods: We performed a retrospective review of vertebrobasilar aneurysms treated with the PED at 4 high-volume neurovascular centers. Read More

Acta Neurochir Suppl 2019;125:151-158

Service de neurochirurgie, CHU, Strasbourg, France.

Compression syndromes of the vertebral artery that occur at the craniocervical junction are extremely rare causes of haemodynamic insufficiency of the posterior cerebral circulation. The aetiology of the compression syndrome may be a malformation, trauma, tumour, infection or degenerative pathology. This may lead to dynamic vertebral artery occlusion where the vessel courses around the atlas and the axis-the so-called V3 segment. Read More

Stroke 2019 Feb;50(2):495-497

From the Department of Neurosurgery (S.A.-H., C.J.S., X.D., L.R.-F., F.T.C.), University of Illinois at Chicago.

Background and Purpose- Cerebral hypoperfusion symptoms (defined as symptoms related to change in position, effort or exertion, or recent change in antihypertensive medication) have been used in stroke studies as a surrogate for detecting hemodynamic compromise. However, the validity of these symptoms in identifying flow compromise in patients has not been well established. We examined whether hypoperfusion symptoms correlated with quantitative measurements of flow compromise in the prospective, observational VERiTAS study (Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke). Read More

Ann Clin Transl Neurol 2018 Dec 12;5(12):1562-1573. Epub 2018 Oct 12.

Department of Image People's Hospital of Zhengzhou Affiliated to Southern Medical University Zhengzhou China.

Objective: To investigate the association between the perfusion magnetic resonance imaging (MRI) and vertebrobasilar dolichoectasia (VBD) in vertigo patients and at least one vascular risk factor.

Methods: We studied 289 patients with vertigo (spinning, swaying, nausea, vomiting, and unsteady gait) who performed multimode MRI. Maximum diameter and tortuous parameters of the basilar artery and vertebral arteries were calculated using magnetic resonance angiography. Read More

Clin Neurol Neurosurg 2019 Jan 29;176:78-82. Epub 2018 Nov 29.

Department of Neurology, Baotou Central Hospital, Baotou, Inner Mongolia, China. Electronic address:

Objective: To compare the safety and efficacy of endovascular therapy in acute ischemic stroke (AIS) caused by large artery occlusion (LAO) in the posterior circulation with or without intracranial atherosclerosis (ICAS).

Patient And Methods: The study enrolled patients who underwent endovascular therapy for AIS caused by posterior circulation LAO. Inclusion criteria for endovascular therapy of vertebrobasilar occlusion were as follows: (1) CTA or MRA confirmed acute vertebrobasilar occlusion; (2) baseline NIHSS score ≥2; (3) premorbid mRS score ≤2; (4) onset or last known well time to puncture within 24 h; (5) pc-ASPECTS ≥6. Read More

Med Sci Monit 2018 Dec 12;24:9001-9006. Epub 2018 Dec 12.

Department of Radiology, Baoding First Central Hospital, Beijing, China (mainland).

BACKGROUND The present study was designed to evaluate the predictive value of head-neck computed tomography angiography (CTA) combined with ABCD2 score scale for patients with cerebral infarction of vertebrobasilar transient ischemic attack (TIA). MATERIAL AND METHODS A total of 92 patients with TIA who were admitted to our hospital from January 2014 to June 2015 were enrolled in this study. ABCD2 score and CTA combined with ABCD2 score were assessed. Read More

Angiol Sosud Khir 2018;24(4):104-108

Clinic of Faculty Surgery, Samara State Medical University of the RF Ministry of Public Health, Samara, Russia.

The authors examined efficacy of carotid endarterectomy (CEA) in treatment of patients suffering from vertebrobasilar insufficiency (VBI) without significant involvement of the vertebral arteries. The study included a total of 297 patients with VBI and diagnosed as having stenosis of the bifurcation of the carotid arteries amounting to 70% and more, with no significant involvement of the vertebral arteries revealed. All patients underwent CEA: eversion CEA was performed in 226 (76. Read More

Case Rep Neurol 2018 Sep-Dec;10(3):322-327. Epub 2018 Nov 14.

Department of Neurology, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.

Cerebral ischemia may be rarely associated with a hypoplastic vertebrobasilar system. Intracranial lipoma is also a very rare congenital malformation. We report the case of a 52-year-old woman with vertebrobasilar transient ischemic attack associated with basilar artery hypoplasia and coincidental intracranial lipoma. Read More

eNeurologicalSci 2018 Dec 9;13:26-30. Epub 2018 Nov 9.

Department of Neurology, University Hospital of Heraklion, University of Crete, Greece.

Stroke is a frequent occurrence among patients suffering from systemic lupus erythematosus (SLE), but it rarely occurs as the initial manifestation of the disease. We here present the case of a 37 year-old patient who developed an acute cerebellar ischemic stroke as initial event of SLE: elevated partial thromboplastin time and ESR, thrombocytopenia, anti-ds-DNA, anti-SSA, anti-JO-1, and the lupus anticoagulant were detected, and the diagnosis of SLE was established. In addition, we reviewed the literature in order to clarify the demographic, clinical, imaging and outcome characteristics of such a presentation, and found 10 similar cases. Read More

World Neurosurg 2019 Feb 29;122:620-631. Epub 2018 Nov 29.

Department of Neurosurgery, SanBo Brain Hospital, Capital Medical University, Beijing, China; Department of Neurosurgery, Fuxing Hospital, Capital Medical University, Beijing, China.

Objective: The repositioning of a dolichoectatic vertebrobasilar artery (VBA) for arterial decompression has been extensively used in the clinical setting. We aimed to describe and summarize the technical characteristics and clinical results of the sling technique.

Methods: The terms "dolichoectatic aneurysm," "dolichoectasia," "ectasia," and "megadolichoectasia" were used to search for pertinent reports related to the VBA territory. Read More

Interv Neuroradiol 2018 Dec 4:1591019918811800. Epub 2018 Dec 4.

1 Department of Interventional Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background: Therapeutic strategies and outcomes vary with stroke subtypes for patients with acute vertebrobasilar occlusion (VBAO). This study aimed to compare characteristics and outcomes of VBAO due to intracranial atherosclerotic disease (ICAD) and embolisms and identify baseline predictors of ICAD.

Methods: Patients with VBAO who received endovascular therapy (EVT) were retrospectively analyzed. Read More

Medicine (Baltimore) 2018 Nov;97(48):e13166

Department of Radiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.

This study aims to analyze the clinical and imaging features of vertebrobasilar dolichoectasia (VBD) combined with posterior circulation infarction, and to explore risk factors for the occurrence of posterior circulation infarction in VBD patients.VBD patients were divided into 2 groups, according to the results of the imaging examination: posterior circulation infarction group and nonposterior circulation infarction group. The demographics, vascular risk factors, imaging, and other clinical data of the VBD patients were collected and retrospectively compared, and the risk factors for the occurrence of posterior circulation infarction in VBD patients were analyzed. Read More

Clin Neuroradiol 2018 Nov 29. Epub 2018 Nov 29.

Department of Interventional Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Purpose: To investigate the predictors for good outcome of endovascular therapy (EVT) for patients with acute vertebrobasilar artery occlusion (VBAO) due to intracranial atherosclerosis stenosis (ICAS).

Methods: From April 2012 to February 2018, patients with VBAO due to ICAS who received EVT were retrospectively analyzed. ICAS was defined as fixed stenosis of >70%, or a degree of fixed stenosis >50% in addition to either perfusion impairment or evidence to re-occlusion. Read More

Front Neurol 2018 15;9:974. Epub 2018 Nov 15.

Department of Neurology, People's Hospital of Zhengzhou Affiliated to Southern Medical University, Zhengzhou, China.

The aim of this study was to determine the prevalence and associated factors of stroke and hypoperfusion among patients with isolated vertigo and vascular risk factors. We studied 157 patients with isolated vertigo who had undergone multimodal magnetic resonance imaging. Magnetic resonance angiography (MRA) was used to measure the diameters of vertebrobasilar arteries and to evaluate morphologic changes to vessels. Read More

World Neurosurg 2019 Feb 19;122:665-670. Epub 2018 Nov 19.

Department of Neurology, The First People's Hospital of Jining, Jining, Shandong, China. Electronic address:

Background: Stenosis of the target intracranial vertebral artery is one of the major causes of posterior circulation ischemic stroke. The objective of this paper is to explore methods for reducing the occurrence of medullary artery occlusion after intracranial vertebral artery stenting.

Case Description: The current research presents a retrospective analysis of 48 patients who received Gateway-Wingspan stent angioplasty to treat severe stenosis of the intracranial vertebral artery, evaluates the results of stenosis remission and perfusion improvement after stent angioplasty, and explores the causes of postoperative medullary artery occlusion. Read More

J Clin Neurosci 2019 Mar 12;61:296-297. Epub 2018 Nov 12.

Mayo Clinic Department of Neurology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Background: Vertebrobasilar dolichoectasia (VBDE) can present with brainstem- compressive symptoms, cerebral ischemia, or hemorrhage. Herein we describe a unique patient with VBDE who presented with hemorrhage and cerebral ischemia simultaneously.

Case: Patient is a 76-year-old man presenting with an acute, symptomatic left pontine ischemic stroke heralded by ataxic dysarthria and right ataxic-hemiparesis. Read More

Interv Neurol 2018 Oct 8;7(6):370-377. Epub 2018 Jun 8.

Emory University School of Medicine/Marcus Stroke & Neuroscience Center - Grady Memorial Hospital, Atlanta, Georgia, USA.

Introduction: Symptomatic intracranial hemorrhage represents one of the most feared complications of endovascular reperfusion. We aim to describe a series of patients that experienced immediate reperfusion injury with active intraprocedural extravasation within the territory of the deep penetrating arteries and provide real-time correlation with CT "spot sign."

Methods: This was a retrospective analysis of patients that suffered reperfusion injury with active arterial extravasation during endovascular stroke treatment in two tertiary care centers. Read More

Rinsho Shinkeigaku 2018 Oct 29;58(10):631-635. Epub 2018 Sep 29.

Department of Neurology, Kyoto Second Red Cross Hospital.

A 61-year-old man, with a history of right clavicular fracture 35 years prior, visited our hospital due to the sudden onset of vertigo and tinnitus following weakness and numbness in his left arm and leg. He also had a 6-month history of right arm pain with overuse. Brain MRI showed acute brain infarcts in the right posterior cerebral artery territory. Read More

J Stroke Cerebrovasc Dis 2018 Dec 23;27(12):3503-3504. Epub 2018 Sep 23.

Department of Neurosurgery, Kawasaki Municipal Hospital, Kawasaki city, Kanagawa, Japan.

Vertebrobasilar dolichoectasia sometimes presents with symptoms related to mass effect like cranial nerve palsies, or with ischemia or hemorrhage. Symptomatic hydrocephalus as a complication of vertebrobasilar dolichoectasia is extremely uncommon. Furthermore, there are few cases of vertebrobasilar dolichoectasia, in which cerebrospinal fluid flow disorder mechanisms are clearly demonstrated in neuroimaging findings. Read More

Front Neurol 2018 10;9:733. Epub 2018 Sep 10.

Department of Neurosurgery, University Hospital Tübingen, Tübingen, Germany.

Neurofibromatosis Type 2 (NF2) is an autosomal-dominant tumor-prone disorder characterized by the manifestations of central nervous system lesions. However, the first clinical signs of disease are often non-tumorous. Cerebrovascular insults are known in NF2, however, not yet described as first symptom in young NF2 patients. Read More

Zhonghua Yi Xue Za Zhi 2018 Sep;98(33):2636-2640

Department of Neurology, Henan Provincial People's Hospital, Zhengzhou 450003, China.

To explore the neuroimaging characteristics associated with the presence of patent foramen ovale(PFO) for patients with cryptogenic stroke. We retrospectively collected the clinical and imaging data of cryptogenic stroke patients with PFO and without PFO from Henan Province People's Hospital from January 1, 2013 to June 30, 2017. Lesion patterns and pertinent vascular territory were compared between the two groups. Read More

Acta Medica (Hradec Kralove) 2018;61(2):74-77

Department of Neurology, Comprehensive Stroke Center, Charles University, Faculty of Medicine and University Hospital, Hradec Králové, Czech Republic.

Introduction: Causality of marijuana abuse with development of ischemic stroke has been indicated by numerous case reports and epidemiological studies. As a possible pathophysiological mechanism, the most common consideration is cardiac embolization during paroxysmal atrial fibrillation, systemic hypotension or multifocal intracerebral vasoconstriction.

Case Reports: We present three case reports of marijuana consumers who were admitted to our comprehensive stroke center due to ischemic stroke within 18-month period of our investigation. Read More

Cas Lek Cesk Summer 2018;157(4):188-194

The benefit of mechanical thrombectomy over intravenous thrombolysis was definitively proved by several studies in 2015. It is relevant for proximal, large artery occlusions in the anterior circulation with onset of clinical symptoms lasting 6 hours. Two trials published in 2018 showed that in patients who are selected using CT perfusion or MR diffusion weighted imaging, thrombectomy significantly improves outcome even up to 24 hours from onset. Read More

Atherosclerosis 2018 Oct 17;277:42-46. Epub 2018 Aug 17.

Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung, Taiwan; Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan; Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan. Electronic address:

Background And Aims: Cervical spondylosis (CS) is reported to be associated with vertebrobasilar insufficiency. However, few cohort studies have investigated the association between CS and posterior circulation ischemic stroke.

Methods: The study cohort comprised 27,990 patients aged ≥18 years with a first diagnosis of CS. Read More

J Neurointerv Surg 2019 Apr 30;11(4):400-404. Epub 2018 Aug 30.

Department of Neurosurgery, Severance Hospital Stroke Center, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: Little has been reported about the feasibility and durability of a Low-profile Visualized Intraluminal Support Junior (LVIS Jr) Y-stenting device for wide-neck bifurcation aneurysms.

Purpose: To evaluate the feasibility and durability of LVIS Jr Y-stenting for coiling of unruptured wide-neck bifurcation aneurysms.

Methods: We identified patients in whom LVIS Jr Y-stenting was attempted for unruptured wide-neck bifurcation aneurysms from a prospectively maintained registry of a referral hospital. Read More

J Stroke Cerebrovasc Dis 2018 Nov 25;27(11):3294-3300. Epub 2018 Aug 25.

Marcyhealth Rockford, Rockford, Illinois.

Background: We performed this study to identify demographic, clinical, and angiographic characteristics of adult patients with angiographically confirmed vertebral artery occlusive disease (VAOD) and associated risk factors.

Methods: The demographic and clinical characteristics, and angiographic features were ascertained using predefined criteria. Controls were selected from the National Health and Nutrition Examination Surveys matched according to age, sex, and ethnicity. Read More

No Shinkei Geka 2018 Aug;46(8):663-671

Department of Neurosurgery, Kobe University Graduate School of Medicine.

Objective: Vertebral artery injury(VAI)associated with cervical spine trauma has the potential to cause catastrophic vertebrobasilar stroke. However, there are no well-defined treatment recommendations for VAI. The purpose of this study was to identify an effective treatment strategy for VAI following cervical spine trauma. Read More

J Stroke Cerebrovasc Dis 2018 Nov 6;27(11):3030-3035. Epub 2018 Aug 6.

Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing, Jiangsu Province 210002. Electronic address:

Background: The incidence and predictors for in-stent restenosis (ISR) was not fully explored. We aim to investigate the incidence and predictors of ISR after stenting at the origin of vertebral artery.

Materials And Methods: Two hundred and six patients with 229 stents implantation between July 1, 2005 and July 31, 2015 were included in the study. Read More

Adv Gerontol 2018;31(2):266-272

Saint-Petersburg State University, 7-9, Universitetskaya emb., St. Petersburg, 199034, Russian Federation;

Current research aimed to reveal clinical and neurological features of ischaemic stroke (IS) in patients suffering from cerebral venous insufficiency (CVI) combined with arterial hypertension (AH) and to identify its risk factors. Examination data of 112 patients with IS (aged 60-93 years old; mean age 72,1±2,6 years old, males - 39 (34,8%), females - 73 (65,2%), admitted at regional vascular center of St. Elizabeth City Hospital in Saint Petersburg, highlighted that cephalgic syndrome and vestibulocerebellar dysfunction occurred more frequently in stroke patients with CVI. Read More