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    1921 results match your criteria Verrucous Carcinoma

    1 OF 39

    A Retrospective 20-Year Analysis of Proliferative Verrucous Leukoplakia and Its Progression to Malignancy and Association with High-risk Human Papillomavirus.
    Head Neck Pathol 2018 Feb 9. Epub 2018 Feb 9.
    Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, 1395 Center Drive, Gainesville, FL, 32610, USA.
    Proliferative verrucous leukoplakia (PVL) is defined as an aggressive, relentless and recalcitrant form of leukoplakia that has a high propensity for malignant transformation. The aim of this study was to evaluate the malignant potential of PVL and determine its possible association with high-risk human papillomavirus (HPV). Twenty cases with a clinical and biopsy proven diagnosis of PVL were collected from the University of Florida Oral Medicine clinic database. Read More

    [A Patient with Lower Lip Verrucous Carcinoma Treated with a Tongue Flap for Functional and Esthetic Reconstruction].
    Gan To Kagaku Ryoho 2017 Nov;44(12):1936-1938
    Dept. of Oral and Maxillofacial Surgery, National Hospital Organization Hamada Medical Center.
    Surgery is generally indicated for the treatment of lower lip carcinoma. However, surgery can lead to esthetic as well as functional issues, with disturbances in eating and articulation. If the defect involves less than one-third of the width of the lower lip, primary closure is possible. Read More

    Squamous cell carcinoma from oral lichen planus: a case report of a lesion with 28 years of evolution.
    J Korean Assoc Oral Maxillofac Surg 2017 Dec 27;43(Suppl 1):S14-S18. Epub 2017 Dec 27.
    Department of Dentistry, Sagrado Coração University, Bauru, Brazil.
    Lichen planus (LP) is a relatively common mucocutaneous disease with autoimmune etiology. Considering its malignancy potential, it is important to define the correct diagnosis, treatment, and clinical follow-up for patients with LP so that the disease is not diagnosed late, thus hindering the chances of curing the disease. This study aims to describe a clinical case of oral squamous cell carcinoma, potentially originated from LP. Read More

    Versatility of Modified Nasolabial Flap in Oral and Maxillofacial Surgery.
    Arch Craniofac Surg 2017 Dec 23;18(4):243-248. Epub 2017 Dec 23.
    Department of Oral & Maxillofacial Surgery, Sri Aurobindo College of Dentistry, Indore, India.
    Background: To evaluate the versatility and reach of modified nasolabial flap used in reconstruction of defects created in and around the oral cavity.

    Methods: A total number of 20 cases were selected. Out of which 13 were males and 7 females. Read More

    Oral Verrucous Carcinoma: Ten Year Experience from a Tertiary Care Hospital in India.
    Indian J Med Paediatr Oncol 2017 Oct-Dec;38(4):452-455
    Department of General Surgery Unit 1 (Including Head and Neck Surgery), Paul Brand Building, Christian Medical College, Vellore, Tamil Nadu, India.
    Background: Verrucous carcinoma of the oral cavity (OVC) is an uncommon variant of oral squamous cell carcinoma (OSCC). The clinical presentation and surgical outcomes of OVC are unique; however, the management protocols for OVC are largely extrapolated from OSCC.

    Objectives: The aim is to study the clinical, histopathological demographics, and outcome of OVC at a tertiary care referral hospital in South India. Read More

    Malignant Transformation of a Site of Prior Diabetic Foot Ulceration to Verrucous Carcinoma: A Case Report.
    Wounds 2017 Dec;29(12):E125-E131
    Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Hospital and Health Systems, Ann Arbor, MI.
    The case of a 62-year-old Caucasian man with type 1 diabetes who developed malignant transformation of an area of prior diabetic foot ulceration (DFU) is reported. He had significant hallux valgus deformity, multiple episodes of healing and breakdown, and eventual transformation to verrucous carcinoma (VC). This case report highlights the malignant transformation of a site of previous DFU to VC, which, to the best of the authors' knowledge, has not yet been described in the literature. Read More

    Modified Cajal's trichrome stain as a diagnostic aid in the study of epithelial pathology.
    Indian J Pathol Microbiol 2017 Oct-Dec;60(4):528-532
    Department of Oral Pathology, Vydehi Institute of Dental Sciences, Bengaluru, Affiliated to Rajiv Gandhi University of Health Sciences, Karnataka, India.
    Background: Diagnosis of initial epithelial pathology maybe difficult in Squamous Cell Carcinoma (SCC), Carcinoma In Situ and other atypical epithelial malignancies, under routine Haematoxylin and Eosin (H and E) stain. The detection of minor basement membrane alterations in doubtful cases is both time consuming and confusing.

    Aims: To evaluate efficacy of Modified Cajal's Trichrome Stain (CTS) in relation to Haematoxylin and Eosin for study of epithelial dysplasia, carcinoma in situ, micro invasive SCC, frank SCC, and SCC in lymph nodes. Read More

    The limitations of dermoscopy: false-positive and false-negative tumours.
    J Eur Acad Dermatol Venereol 2018 Jan 5. Epub 2018 Jan 5.
    First Department of Dermatology, Aristotle University, Thessaloniki, Greece.
    Dermoscopy has been documented to increase the diagnostic accuracy of clinicians evaluating skin tumours, improving their ability to detect skin cancer and better recognize benign moles. However, dermoscopically 'false-positive' and 'false-negative' tumours do exist. False-positive diagnosis usually leads to unnecessary excisions. Read More

    Carcinoma Cuniculatum of the Right Thenar Region with Bone Involvement and Lymph Node Metastases.
    Case Rep Dermatol 2017 Sep-Dec;9(3):225-230. Epub 2017 Nov 10.
    Department of Dermatology, Municipal Hospital Hietzing, Vienna, Austria.
    Squamous cell carcinoma (SCC) is the second most common type of skin cancer after basal cell carcinoma (BCC). The overall prevalence of BCC is 3 times higher than that of SCC, but this can vary when looking at specific locations such as the hand, where SCC is much more common than BCC. Carcinoma (or epithelioma) cuniculatum is a rare variant of SCC. Read More

    Oral manifestation of histoplasmosis on the palate.
    An Bras Dermatol 2017 ;92(5 Suppl 1):107-109
    Department of Conservative Dentistry - Faculdade de Odontologia - Universidade Federal do Rio Grande do Sul (UFRGS) - Porto Alegre (RS), Brazil.
    This case report describes an uncommon manifestation of histoplasmosis on the soft palate. The importance of appropriate treatment and follow-up in complex cases is emphasized, especially in patients with chronic diseases. Oral lesions may occur as multiple, granular and painful ulcers, as well as verrucous growths. Read More

    Acral melanoma foot lesions. Part 2: clinical presentation, diagnosis, and management.
    Clin Exp Dermatol 2018 Mar 13;43(2):117-123. Epub 2017 Dec 13.
    Department of Dermatology, State University of New York Downstate Medical Center, Brooklyn, NY, USA.
    Acral melanoma (AM) is a rare subtype of cutaneous malignant melanoma found on acral skin, primarily on the soles of the feet. Although rare, it is the most common subtype of melanoma found in patients of African or Asian ethnicity and has a poor prognosis, often because of the more advanced stage of presentation at diagnosis. In the second of this two-part series, we review the clinical presentation, histopathology, diagnosis and management of AM. Read More

    [Morphology of non cutaneous head and neck squamous cell carcinoma].
    Pathologe 2018 Feb;39(1):3-10
    Institut für Pathologie, Universitätsklinikum Erlangen, Erlangen, Deutschland.
    Head and neck squamous cell carcinoma (HNSCC) is by far the most frequent malignant tumor in this anatomic region. Today, HNSCC is divided into two morphologically, molecularly and clinically fundamentally different entities: conventional and virus-associated (HPV/EBV) neoplasms. Premalignant lesions of nonvirus-associated HNSCC include conventional leukoplakia, dysplasia and proliferative verrucous hyperplasia with an increasing risk for malignant transformation. Read More

    Downregulation of Notch4 - a prognostic marker in distinguishing oral verrucous carcinoma from oral squamous cell carcinoma.
    Braz J Otorhinolaryngol 2017 Oct 31. Epub 2017 Oct 31.
    SRM University, School of Bioengineering, Department of Genetic Engineering, Kattankulathur, India. Electronic address:
    Introduction: Oral verrucous carcinoma is a special form of well-differentiated squamous cell carcinoma which possesses specific clinical, morphologic and cytokinetic features that differ from other types of oral cancers and hence diagnosis requires immense experience in histopathology. Hence it is certainly important to distinguish such a lesion from other oral tumors as treatment strategies vary widely between them.

    Objective: In search of a critical diagnostic marker in distinguishing oral verrucous carcinoma from oral squamous cell carcinoma, Notch4 receptor, one of the key regulatory molecules of the Notch signaling family has been aberrantly activated in the progression of several types of tumors. Read More

    [Keratoacanthomas on recent tattoos: Two cases].
    Ann Dermatol Venereol 2017 Dec 7;144(12):776-783. Epub 2017 Nov 7.
    Consultation « tatouage », service de dermatologie, hôpital Bichat - Claude-Bernard, hôpitaux universitaires Paris-Nord-Val-de-Seine, 46, rue Henri-Huchard, 75018 Paris, France.
    Background: Increasing numbers of reports of rapidly arising, isolated or eruptive keratoacanthomas (KA) and squamous cell carcinomas (CSC) on the red part of tattoos tend to suggest a non-fortuitous link with the procedure. We report herein two different presentations of KAs on tattoos: one patient with multiple eruptive KAs on sun-exposed areas of a recent red tattoo and another with a solitary lesion on a recent tattoo. We discuss the issues related to the distinction between KAs and CSCs in this particular context. Read More

    A comparative study of the cutaneous side effects between BRAF monotherapy and BRAF/MEK inhibitor combination therapy in patients with advanced melanoma: a single-centre experience.
    Eur J Dermatol 2017 Oct;27(5):482-486
    Unit of Dermatology, University of Padua, Via Gallucci 4, 35128 Padova, Italy.
    Patients with advanced melanoma have a poor prognosis. Since the discovery of BRAF mutations in cutaneous melanoma, new pharmacological agents have been developed to inhibit this target. Although the survival of patients with advanced melanoma has improved with BRAF inhibitors, the emergence of drug resistance and the high incidence of cutaneous side effects represent important limitations. Read More

    A report on the clinical-pathological correlations of 788 gingival lesion.
    Med Oral Patol Oral Cir Bucal 2017 Nov 1;22(6):e686-e693. Epub 2017 Nov 1.
    Department of Surgical Sciences, University of Turin, CIR - Dental School, Oral Medicine Section, Via Nizza 230, 10126 Turin, Italy,
    Background: The diagnosis and treatment of a variety of non-plaque related gingival diseases have become an integrated aspect of everyday dentistry. The aim of this study was to analyse the relationship between clinical appearance and histopathological features of gingival lesions in a large Northern Italian population.

    Material And Methods: A retrospective study of 788 cases of gingival and alveolar mucosal biopsies was set up. Read More

    Chromoblastomycosis of the leg.
    Pol J Pathol 2017;68(2):182-184
    Case Report: We herein report a case of chromoblastomycosis presenting as a verrucous lesion over the leg. A 56-year-old male patient was a known case of carcinoma larynx and was treated for the same. At presentation to our hospital, the patient, in addition to the recurrent local disease, was suspected to have second primary in the form of verrucous carcinoma of the leg. Read More

    The Spectrum of Oral Lesions Presenting Clinically With Papillary-Verrucous Features.
    J Oral Maxillofac Surg 2017 Aug 24. Epub 2017 Aug 24.
    Professor and Oral Pathologist, Goldschleger School of Dental Medicine and Sackler School of Medicine, Tel Aviv University, and Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
    Purpose: We sought to study the spectrum of oral pathologies presenting clinically with papillary-verrucous features.

    Materials And Methods: A 10-year (2007 to 2016) retrospective study of oral papillary lesions was undertaken. All biopsy reports that included a clinical description of papillary or verrucous architecture were retrieved. Read More

    Simultaneous Development of Three Different Neoplasms of Trichilemmoma, Desmoplastic Trichilemmoma and Basal Cell Carcinoma Arising from Nevus Sebaceus.
    Arch Craniofac Surg 2017 Mar 25;18(1):46-49. Epub 2017 Mar 25.
    Department of Pathology, Busan-Baik Hospital, Inje University School of Medicine, Busan, Korea.
    Nevus sebaceus is a hamartoma of the sebaceous gland that occurs congenitally, from which various secondary tumors can arise with a prevalence of 5%-6%. Benign neoplasms commonly arise from nevus sebaceous, but they have a very low malignant potential. Two neoplasms may occasionally arise within the same lesion, but it is rare for three or more neoplasms to occur in a nevus sebaceus simultaneously. Read More

    A case of reccuring giant condyloma of vulva in infant without sexual abuse successfully treated with electrocoagulation in Benin.
    Pan Afr Med J 2017 30;27:159. Epub 2017 Jun 30.
    Dermatology-Venereology, Faculty of Health, Cotonou, University of Abomey-Calavi, R. Benin.
    We report here a case of giant vulval condyloma in a two-year-old infant infected by her "baby sitter" without sexual abuse. Treated by surgical excision coupled with electrocoagulation, it was noted a rapid recurrence two weeks after treatment requiring a second electrocoagulation session. More than a year later, no lesion was noted, thus demonstrating therapeutic success. Read More

    Epidemiology and survival outcomes of sinonasal verrucous carcinoma in the United States.
    Laryngoscope 2018 Mar 2;128(3):651-656. Epub 2017 Sep 2.
    Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California, U.S.A.
    Introduction: Verrucous carcinoma (VC) is a rare, variant of squamous cell carcinoma with benign cytohistopathologic features and a generally favorable prognosis. Epidemiologic and clinical outcomes data are lacking as a result of limited cases of sinonasal VC.

    Objective: To describe the incidence and determinants of survival of patients with verrucous carcinoma of the sinonasal tract between the years of 1973 to 2014 using the Surveillance, Epidemiology, and End Results (SEER) database. Read More

    A population-based analysis of verrucous carcinoma of the oral cavity.
    Laryngoscope 2018 Feb 29;128(2):393-397. Epub 2017 Aug 29.
    Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA; the UCLA Head and Neck Cancer Program, Los Angeles, California, U.S.A.
    Objectives: To describe the incidence and determinants of survival of patients with verrucous carcinoma (VC) of the oral cavity between the years of 1973 and 2012 using the Surveillance, Epidemiology, and End Results (SEER) database.

    Study Design: Retrospective cohort study using a national database.

    Methods: The SEER registry was utilized to calculate survival trends for patients with VC of the oral cavity between 1973 and 2012. Read More

    CpG location and methylation level are crucial factors for the early detection of oral squamous cell carcinoma in brushing samples using bisulfite sequencing of a 13-gene panel.
    Clin Epigenetics 2017 15;9:85. Epub 2017 Aug 15.
    "M. Malpighi" Section of Anatomic Pathology, Department of Biomedical and Neuromotor Sciences, Bellaria Hospital, University of Bologna, via Altura n.3, 40137 Bologna, Italy.
    Background: Oral squamous cell carcinoma (OSCC) is usually diagnosed at an advanced stage and is commonly preceded by oral premalignant lesions. The mortality rates have remained unchanged (50% within 5 years after diagnosis), and it is related to tobacco smoking and alcohol intake. Novel molecular markers for early diagnosis are urgently needed. Read More

    Acquired epidermodysplasia verruciformis occurring in a renal transplant recipient.
    Cutis 2017 May;99(5):E9-E12
    Department of Dermatology, Geisinger Medical Center, Danville, Pennsylvania, USA.
    Acquired epidermodysplasia verruciformis (EDV) is a rare condition occurring in patients with depressed cellular immunity, particularly individuals with human immunodeficiency virus (HIV). Acquired EDV is less commonly reported in recipients of stem cell or solid organ transplantation. This condition typically manifests within 5 years of initial immunosuppression and can present as multiple hypopigmented to red, tinea versicolor-like macules or as multiple verrucous, flat-topped papules distributed over the trunk, arms, and legs. Read More

    Research on miRNA-195 and target gene CDK6 in oral verrucous carcinoma.
    Cancer Gene Ther 2017 Jul 16;24(7):282-288. Epub 2017 Jun 16.
    Department of oral and maxillofacial surgery, Central South University &Xiangya Stomatology Hospital, Changsha, Hunan Province, China.
    Oral verrucous carcinoma (OVC) is a verrucous variant of oral cavity squamous carcinoma (OSCC). The expression of miRNA from OVC and OSCC including their matched normal oral mucosa tissues was profiled through the Affymetrix GeneChip miRNA Arrays. TargetScan and miRanda databases were used to predict the target gene of miRNA-195. Read More

    Human Papilloma Virus-Associated Lips Verrucous Carcinoma in HIV-Infected Male.
    J Int Assoc Provid AIDS Care 2017 Jul/Aug;16(4):324-326. Epub 2017 Jun 1.
    3 Department of Dermatology, "Santa Maria della Misericordia" Hospital, University of Perugia, Perugia, Italy.
    Human papillomavirus (HPV) infection, widely known as the necessary cause of cervical cancer, has been established as a major etiologic factor for head and neck cancer (HNC). HIV-infected individuals are at higher risk of HPV-associated cancers than the general population. We describe a 45-year-old man with HIV and HPV coinfection, who presented progressively enlarging verrucous neoformations of the lips. Read More

    Dermoscopic Analysis of Nevus Sebaceus of Jadassohn: A Study of 13 Cases.
    Skin Appendage Disord 2017 May 16;3(2):83-91. Epub 2017 Mar 16.
    Department of Dermatology, University Hospital Hassan II, Fez, Morocco.
    Background: Nevus sebaceus of Jadassohn (NSJ) is a complex cutaneous hamartoma with various clinical appearances.

    Aim: To describe different dermoscopic patterns of this nevus according to its evolutionary stages.

    Methods: This was an analytical study of NSJ carried out in the Department of Dermatology at the University Hospital Hassan II, Fez, Morocco. Read More

    Comorbidity between HTLV-1-associated adult T-cell lymphoma/leukemia and verrucous carcinoma: a case report.
    Colomb Med (Cali) 2017 Mar 30;48(1):35-38. Epub 2017 Mar 30.
    Escuela de Medicina Facultad de Salud, Universidad del Valle Cali, Colombia.
    Background: Adult T-cell Leukemia/Lymphoma (ATLL) is classified as a peripheral CD4+ T-cell neoplasm caused by the human T-cell lymphotropic virus type 1 (HTLV-1). Typical symptoms are associated with leukemic infiltration; however, atypical and exaggerated manifestations of verrucous carcinoma have also been described.

    Case Report: We present here the case of a patient with multiple skin lesions, ischemic necrosis in the hallux and lymphadenopathies. Read More

    Verrucous carcinoma of the vulva: diagnosis and treatment.
    An Bras Dermatol 2017 Mar-Apr;92(2):243-245
    Dermatology Clinic at Irmandade da Santa Casa de Misericórdia de São Paulo - São Paulo (SP), Brazil.
    Vulvar cancer accounts for less than 1% of malignancies in women. Verrucous carcinoma of the vulva is a rare histological variation, comprising less than 1% of vulvar cancer cases. Although it is characterized as being locally invasive, the condition is not associated with metastatic spreading. Read More

    Atypical presentations of cutaneous leishmaniasis: A systematic review.
    Acta Trop 2017 Aug 17;172:240-254. Epub 2017 May 17.
    Laboratory of Microbiology and Parasitology, Faculty of Medicine, Federal University of Cariri, UFCA, Barbalha, Ceará, Brazil. Electronic address:
    Cutaneous Leishmaniasis (CL) is endemic in 88 countries, showing relevant prevalences. The aim of this study was to perform a systematic review on atypical lesions of CL around the world, addressing clinico-epidemiological, immunological and therapeutic aspects. A search of the literature was conducted via electronic databases Scopus and PubMed for articles published between 2010 and 2015. Read More

    A Giant Cutaneous Horn Projecting from Verrucous Carcinoma of Buccal Mucosa: A Rare Case Report.
    J Clin Diagn Res 2017 Mar 1;11(3):ZD04-ZD05. Epub 2017 Mar 1.
    Reader, Department of Conservative Dentistry and Endodontics, Patna Dental College and Hospital, Patna, Bihar, India.
    Cutaneous horn is conical shape of compact keratin that resembles a miniature animal horn. Though morphologically similar to horns in animals they are histologically very different from them. It is a circumscribed, conical, hyperkeratotic dense protrusion with epithelial cornification above the skin surface in response to a wide range of underlying benign and malignant pathological changes. Read More

    Good Prognosis Went Badly: Fulminant Evolution of a 29-Year-Old Patient with Verrucous Carcinoma of the Cervix.
    J Adolesc Young Adult Oncol 2017 Sep 12;6(3):499-502. Epub 2017 May 12.
    2 University of Medicine and Pharmacy "Carol Davila ," Bucharest, Romania .
    Verrucous carcinoma (VC) is a very rare variant of squamous cell carcinoma of the cervix, difficult to point out in histology because of its benign appearance. We present the case of a 29-year-old woman with a locally advanced cervical VC who underwent radiotherapy followed by radical hysterectomy. After local relapse and despite pelvic exenteration, her condition deteriorated. Read More

    Photodynamic treatment outcomes of potentially-malignant lesions and malignancies of the head and neck region: A systematic review.
    J Investig Clin Dent 2018 Feb 8;9(1). Epub 2017 May 8.
    Department of Conservative and Endodontics, HSRS Dental College and Hospital, Hingoli, Maharashtra, India.
    Aim: The aim of the present study was to systematically review the efficacy of photodynamic therapy (PDT) in the management of oral potentially-malignant disorders (PMDS) and head and neck squamous cell carcinoma (HNSCC).

    Methods: From 1985 to 2015, PubMed/Medline, Google Scholar, EMBASE, and ISI Web of Knowledge were searched using different combinations of the following key words: PDT, oral precancer, leukoplakia, erythroplakia, erythroleukoplakia, verrucous hyperplasia, oral submucous fibrosis, and HNSCC. Review articles, experimental studies, case reports, commentaries, letters to the editor, unpublished articles, and articles published in languages other than English were excluded. Read More

    Local Excision for the Treatment of Penile Verrucous Carcinoma.
    Urol Case Rep 2017 Jul 10;13:16-18. Epub 2017 Apr 10.
    Department of Urology, Konkuk University School of Medicine, Chungju, Republic of Korea.
    Penile verrucous carcinoma is known for its favorable biologic behavior and lack of metastatic potential. For preservation of function, treatment has been focused on partial penectomy. Despite partial penectomy for preservation of minimal functional and aesthetic aspects, patients have experienced psychosexual problems. Read More

    Verrucous Hyperplasia: Case report and differential diagnosis.
    Sultan Qaboos Univ Med J 2017 Feb 30;17(1):e98-e102. Epub 2017 Mar 30.
    Department of Periodontics, Christian Dental College & Hospital, Ludhiana, Punjab, India.
    Verrucous hyperplasia (VH) is a rare exophytic oral mucosal lesion which can transform into verrucous carcinoma (VC), its malignant but clinically similar counterpart. These entities can be distinguished by the lack of invasive growth in VH cases; as such, it is essential to include a margin with adequate depth when performing a biopsy of the epithelium of the lesion. We report an 80-year-old male patient who presented to the Bapuji Dental College & Hospital, Davangere, Karanataka, India, in 2011 with a warty whitish-pink growth on the inside of his cheek. Read More

    Pseudoepitheliomatous keratotic and micaceous balanitis treated with topical 5-fluorouracil and liquid nitrogen.
    Clin Exp Dermatol 2017 Apr 13. Epub 2017 Apr 13.
    Dermatology Department, National Skin Centre, Singapore.
    Pseudoepitheliomatous keratotic and micaceous balanitis (PKMB) is an uncommon premalignant condition involving the glans penis. We report the case of an 86-year-old man who presented with phimosis and pain on retracting his foreskin. He had previously undergone circumcision, which revealed a hyperkeratotic plaque with thin mica-like scales involving his glans penis. Read More

    Rare "Inverted" Verrucous Carcinoma (Carcinoma Cuniculatum) of the Sacrogluteal Region: Case Report and Literature Review.
    Int J Surg Pathol 2017 Aug 1;25(5):438-442. Epub 2017 Feb 1.
    1 Royal Hobart Hospital, Hobart, Tasmania, Australia.
    A 49-year-old woman with a past history of several infundibular cysts in the head and neck region presented with a 6-month history of a nonhealing perianal abscess on a background of 13 years of chronic sacral-buttock abscesses and discharging sinuses as part of hidradenitis suppurativa. After 2 surgical procedures and inadequate healing, a wide local excision was performed. The surgical specimen revealed an extensive, infiltrating, cystic and deeply penetrating, dermal and subcutaneous neoplasm with multiple fistulous tracts extending to the skin surface. Read More

    How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?
    Eur Arch Otorhinolaryngol 2017 Jul 31;274(7):2709-2726. Epub 2017 Mar 31.
    International Head and Neck Scientific Group, Padua, Italy.
    Although the majority of laryngeal malignancies are the conventional squamous cell carcinomas (SCC), a wide variety of malignant epithelial tumors can affect the larynx. Current treatment guidelines are designed to guide clinicians in management of conventional laryngeal SCC. Less is known about the biological behavior and responsiveness to therapy and overall outcomes of other malignant epithelial lesions. Read More

    Verrucoid Variant of Invasive Squamous Cell Carcinoma in Oral Submucous Fibrosis: A Clinicopathological Challenge.
    Cureus 2016 Nov 4;8(11):e862. Epub 2016 Nov 4.
    Department of Oral Pathology, Thai Moogambigai Dental College and Hospital.
    Verrucous carcinoma (VC) is an exophytic, low-grade, well-differentiated variant of squamous cell carcinoma. It is described as a lesion appearing in the sixth or seventh decade of life that has minimal aggressive potential and, in long-standing cases, has been shown to transform into squamous cell carcinoma. Oral submucous fibrosis (OSMF) is a potentially malignant disorder, and about one-third of the affected population develop oral squamous cell carcinoma. Read More

    Topical agents for oral cancer chemoprevention: A systematic review of the literature.
    Oral Oncol 2017 Apr 2;67:153-159. Epub 2017 Mar 2.
    Department of Otolaryngology - Head and Neck Surgery, Wayne State University School of Medicine, Detroit, MI, USA; Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA; Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA.
    Objectives/hypothesis: We review the use of topical chemoprevention agents in patients with oral potentially malignant disorders (PMD).

    Methods: A systematic review of studies on topical chemoprevention agents for oral PMD from 1946 to November 2016 was conducted using the MEDLINE database, Embase, and Cochrane Library. Data were extracted and analyzed from selected studies including study type, sample size, demographics, treatment length, response rate, follow-up time, adverse effects, and recurrence. Read More

    Keratoacanthoma en plaque/nodule: A brief report of the clinicopathological features of five cases.
    J Dermatol 2017 Jul 23;44(7):803-807. Epub 2017 Mar 23.
    Division of Dermatology, Nakao Clinic, Saga, Japan.
    Keratoacanthoma (KA) is characterized by exoendophytic growth with a central keratin-filled crater, representing the crateriform architecture. We herein report five rare cases of KA without a central keratin-filled crater. These KA cases histopathologically showed that one or a few infundibular structures/isthmic lobules had their own open keratotic pores on the surface without a common merged keratotic plug/horn, clinically representing verrucous (keratotic) plaque/nodule, namely, "KA en plaque/nodule". Read More

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