CpG location and methylation level are crucial factors for the early detection of oral squamous cell carcinoma in brushing samples using bisulfite sequencing of a 13-gene panel.
- Luca Morandi,
- Davide Gissi,
- Achille Tarsitano,
- Sofia Asioli,
- Andrea Gabusi,
- Claudio Marchetti,
- Lucio Montebugnoli,
- Maria Pia Foschini
Clin Epigenetics 2017 15;9:85. Epub 2017 Aug 15.
"M. Malpighi" Section of Anatomic Pathology, Department of Biomedical and Neuromotor Sciences, Bellaria Hospital, University of Bologna, via Altura n.3, 40137 Bologna, Italy.
Background: Oral squamous cell carcinoma (OSCC) is usually diagnosed at an advanced stage and is commonly preceded by oral premalignant lesions. The mortality rates have remained unchanged (50% within 5 years after diagnosis), and it is related to tobacco smoking and alcohol intake. Novel molecular markers for early diagnosis are urgently needed. Read More