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Histopathology 2021 May 7. Epub 2021 May 7.

Department of Pathology.

Aims: Esophageal verrucous carcinoma (VSCC) is a rare and morphologically distinct type of esophageal squamous cell carcinoma (SCC). Diagnosing VSCC on biopsy material is challenging given the lack of significant atypia and the presence of keratinizing epithelium and exophytic growth. The molecular pathogenesis of VSCC remains unclear. Read More

J Clin Med 2021 Apr 13;10(8). Epub 2021 Apr 13.

Faculty of Medicine and Dentistry, University of Valencia, 46010 Valencia, Spain.

This study aimed to investigate the role of a panel of salivary cytokines as biomarkers for early detection oral squamous cell carcinoma (OSCC), comparing their levels among healthy individuals, patients with oral leukoplakia (OL), and malignant lesions. Cytokine profiling analysis performed in a minimally invasive sample was correlated with clinicopathological variables in our patient cohorts. Unstimulated saliva was obtained from subjects with OSCC at early ( = 33) and advanced ( = 33) disease, OL with homogeneous ( = 33) and proliferative verrucous ( = 33) clinical presentations, and healthy controls ( = 25). Read More

Am J Dermatopathol 2021 Apr 21. Epub 2021 Apr 21.

UCSF Dermatopathology and Oral Pathology Service, University of California San Francisco, San Francisco, CA; Departments of Pathology and Dermatology, University of California San Francisco, San Francisco, CA; Department of Dermatology, Yale University School of Medicine, New Haven, CT; and Helen Diller Family Cancer Center, University of California San Francisco, San Francisco, CA.

Abstract: Pseudocarcinomatous desmoplastic trichoepithelioma (PDTE) features verrucous squamous epidermal hyperplasia with a jagged undersurface overlying cords of follicular germinative cells in a fibrotic stroma. To date, only 5 cases have been reported. We identified 7 new PDTEs from 2 institutions and reviewed their clinical manifestations and immunohistochemical profile. Read More

J Oncol 2021 13;2021:6663720. Epub 2021 Feb 13.

Department of Surgery, Stomatology, Pathology and Radiology (Area of Pathology), Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil.

Background: The present study aimed to investigate the clinical significance and prognostic value of the immunoexpression of cancer stem cell markers, ALDH1 and Notch1, in subtypes of oral squamous cell carcinoma.

Materials And Methods: The expression of ALDH1 and Notch1 in 63 patients with well and poorly differentiated oral squamous cell carcinomas and their subtypes, verrucous carcinoma and basaloid squamous cell carcinoma, was evaluated by immunohistochemistry. The semi-quantitative analysis of the ALDH1 and Notch immunoexpression levels, based on the capture of 10 microscopic fields, at 400X magnification, at the invasive tumor front was performed and associated with clinicopathological variables using the chi-square test or Fisher's exact test. Read More

J Dermatolog Treat 2021 Apr 14:1-19. Epub 2021 Apr 14.

Cooper Center for Dermatologic Surgery, Evesham, NJ.

Background: Verrucous carcinoma is a rare mucocutaneous malignancy characterized by slow, relentless growth and a low metastasis rate.

Objective: Herein we summarize surgical success rates and review newer approaches to the treatment of verrucous carcinomas. PubMed electronic searches were performed by B. Read More

Sex Transm Dis 2021 Apr 1. Epub 2021 Apr 1.

Associate Professor of Surgery, Department of Surgery, LSU School of Medicine Associate Professor of Surgery, Department of Surgery, LSU School of Medicine Associate Professor of Pathology, Department of Pathology, LSU School of Medicine Associate Professor of Surgery Department of Urology, Tulane School of Medicine Professor of Surgery, Department of Surgery, LSU School of Medicine.

Abstract: Buschke-Lowenstein tumors (B-L) or giant condyloma are large fungating lesions that are caused by HPV and develop in the anogenital region. While uncommon, physicians and surgeons who treat sexually transmitted diseases or other diseases involving the anogenital area will encounter these patients. The purpose of this study is to review the current literature regarding these lesions. Read More

ANZ J Surg 2021 Mar 31. Epub 2021 Mar 31.

Department of Surgery, Rockhampton Base Hospital, Rockhampton, Queensland, Australia.

Ann Pathol 2021 Mar 17. Epub 2021 Mar 17.

Cabinet de dermatopathologie Mathurin-Moreau, hôpital Cochin Paris, Paris 19(e), Paris, France. Electronic address:

Vulvar squamous cell carcinoma arises from precursor lesions: vulvar intraepithelial neoplasias (VIN). Most of them are caused by the human papillomavirus (HPV), and the precursor lesion for this group is VIN usual type/high grade squamous intraepithelial lesion (uVIN/HSIL) of variable clinical presentation and having a light invasive potential. Some VIN are HPV-independent and arise in older women against the background of chronic dermatoses, mostly lichen sclerosus. Read More

Cureus 2021 Feb 4;13(2):e13118. Epub 2021 Feb 4.

Plastic Surgery, Haaglanden Medisch Centrum, The Hague, NLD.

A verrucous carcinoma is a rare, low-grade variant of a well-differentiated squamous cell carcinoma (SCC). It frequently occurs in Caucasian males aged 50 to 60. The tumour is locally destructive, grows into muscle, nerves and bones, but rarely metastasizes. Read More

Prim Dent J 2021 Mar;10(1):10-12

Consultant in Oral Medicine Honorary Professor, University Dental Hospital of Manchester, Central Manchester University Hospitals NHS Foundation Trust, Manchester, and School of Dentistry, University of Manchester.

Oral cancer is a significant cause of morbidity and mortality worldwide. In this article we present two cases of potentially innocuous looking lesions, initially thought to be traumatic in origin, but later diagnosed as cancer. The first patient presented with a persistent laceration thought to be caused by an accidental shaving injury, which was subsequently diagnosed as squamous cell carcinoma. Read More

Ann Maxillofac Surg 2020 Jul-Dec;10(2):488-490. Epub 2020 Jul 2.

Department of Orthodontics and, University of Alabama Birmingham, Birmingham, AL, USA.

The diagnosis of oral white lesions might be quite challenging. White lesions are only 5% of all oral pathologies. Smokeless tobacco (ST), also known as tobacco chewing, spit tobacco, dip, plug, or chew, is one of the well-documented agents that causes white lesions. Read More

Case Rep Med 2021 22;2021:6651925. Epub 2021 Feb 22.

Radiology Department, National Institute of Oncology, Mohammed V University, Rabat, Morocco.

Scrotal verrucous carcinoma is a rare entity. It is rarely metastatic especially in lymph nodes. Imaging is important for local extension in order to guide the surgical procedure. Read More

Indian J Dermatol Venereol Leprol 2021 May-Jun;87(3):388-390

Department of Pathology, University College of Medical Sciences and GTB Hospital (University of Delhi), New Delhi, India.

Oral Oncol 2021 Feb 28;116:105191. Epub 2021 Feb 28.

CIBERONC, Valencia, Spain; Medicina Oral Unit, Stomatology Department, Valencia University, Spain; Department of Stomatology and Maxillofacial Surgery, Hospital General Universitario de Valencia, Valencia, Spain. Electronic address:

Objectives: To explore the pathophysiology of proliferative verrucous leucoplakia (PVL) through a methylated DNA immunoprecipitation and high-throughput sequencing (MeDIP-seq) case-control study.

Materials And Methods: Oral biopsies from ten PVL patients and five healthy individuals were obtained and used to compare their epigenetic patterns. Network biology methods and integrative analyses of MeDIP-seq and RNAseq data were applied to investigate functional relations among differentially methylated genes (DMGs). Read More

Iran J Otorhinolaryngol 2021 Jan;33(114):55-59

Dental Research Center, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction: Verruciform xanthoma (VX) is an uncommon benign lesion with the subepithelial accumulation of foamy histiocytes and superficial papillary proliferations with a bright orange hue. This lesion exhibits an oral region predilection. Its clinical differential diagnosis includes verrucous leukoplakia, verrucous carcinoma, squamous papilloma, verruca vulgaris, condyloma accuminatum, squamous cell carcinoma, and fibroepithelial polyp. Read More

Arch Immunol Ther Exp (Warsz) 2021 Feb 27;69(1). Epub 2021 Feb 27.

Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Dr. Qarib St, Keshavarz Blvd, 14194, Tehran, Iran.

Cancer is one of the most serious diseases affecting health and the second leading cause of death worldwide. Despite the development of various therapeutic modalities to deal with cancer, limited improvement in overall survival of patients has been yielded. Since there is no certain cure for cancer, detection of premalignant lesions, and prevention of their progression are vital to the decline of high morbidity and mortality of cancer. Read More

Skin Appendage Disord 2021 Jan 5;7(1):54-57. Epub 2020 Nov 5.

Department of Dermatology, Medical School, University of São Paulo, São Paulo, Brazil.

Background: Lichen planus (LP) can lead to severe scarring of the nail unit leading to anonychia. There are very few reports of squamous cell carcinoma (SCC) occurring in the lesions of ungual LP.

Objective: The aim of this study was to revise the previously reported cases of SCC appearing in ungual LP and to present a new case. Read More

BMC Urol 2021 Jan 29;21(1):13. Epub 2021 Jan 29.

Department of Urology, Konkuk University School of Medicine, Gukwon-daero 82, 27376, Chungju, Chungbuk, Republic of Korea.

Background: Verrucous carcinoma, a rare low-grade well-differentiated squamous cell carcinoma, is known for its favorable biological behavior and lack of metastatic potential. However, aggressive resection is problematic in terms of compromised function and aesthetics. Hence, more conservative treatments are needed. Read More

J Cutan Pathol 2021 Jan 20. Epub 2021 Jan 20.

Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Oral Oncol 2021 Jan 12:105144. Epub 2021 Jan 12.

Department of Oral Diagnosis, Semiology and Pathology Areas, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.

This report aimed to describe an uncommon case of verrucous carcinoma of the oral cavity with a unique presentation of proliferative verrucous leucoplakia. An 82-year-old female presented multiple white plaques in the oral cavity, which have been treated as candidiasis without resolution. The biopsy specimen demonstrated a well-defined squamous cell epithelium with verrucous aspects. Read More

Head Neck Pathol 2021 Jan 7. Epub 2021 Jan 7.

Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, Gainesville, FL, USA.

The many diverse terms used to describe the wide spectrum of changes seen in proliferative verrucous leukoplakia (PVL) have resulted in disparate clinical management. The objective of this study was to produce an expert consensus guideline for standardized assessment and reporting by pathologists diagnosing PVL related lesions. 299 biopsies from 84 PVL patients from six institutions were selected from patients who had multifocal oral leukoplakic lesions identified over several years (a minimum follow-up period of 36 months). Read More

Head Neck Pathol 2021 Jan 4. Epub 2021 Jan 4.

Department of Oral Pathology, Amrita School of Dentistry, AIMS Campus, AIMS Ponekkara (P.O), Kochi, Kerala, 682041, India.

Carcinoma cuniculatum is a locally aggressive, low-grade variant of squamous cell carcinoma. Though primarily a tumour of the skin, it has also been found to be arising from various mucosal surfaces including oral mucosa. When it occurs in the mandible it starts as a mucosal lesion which progressively invades the jaw and destroys the underlying bone, often presenting as a cystic lesion. Read More

Head Neck Pathol 2021 Jan 4. Epub 2021 Jan 4.

Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.

Carcinoma cuniculatum (CC) is a rare clinicopathologic variant of squamous cell carcinoma. Histologically, it is characterized by invasive growth of bland, acanthotic, and keratinizing squamous epithelium that forms multiple rabbit burrow-like, keratin-filled crypts and sinuses. We present a 51-year-old male smoker with CC of the left vocal cord. Read More

South Asian J Cancer 2020 Jun 14;9(2):99-104. Epub 2020 Dec 14.

Department of Oral Pathology, North Bengal Dental College and Hospital, Darjeeling, West Bengal, India.

 Early detection of dysplastic changes within oral potentially malignant disorders is the mainstay to prevent oral cancer. Ki-67 is one of the most useful antigens in this purpose.  The study aims were to recognize and mutually compare the proliferative status of idiopathic oral leukoplakia (OL) patches, which presented through different forms of dysplasia and carcinoma. Read More

Int J STD AIDS 2021 Feb 20;32(2):209-212. Epub 2020 Dec 20.

Department of Medical Sciences and Public Health, Dermatology Clinic, University of Cagliari, Cagliari, Italy.

We report two cases of histologically documented pseudoepitheliomatous keratotic and micaceous balanitis in middle-aged male patients, which showed positivity for low-risk serotype human papillomavirus DNA. To our knowledge, only one other case has been documented. Further immunohistochemical proliferative markers were performed and compared to literature findings in penile epithelial proliferations. Read More

Photobiomodul Photomed Laser Surg 2021 Jan 17;39(1):53-61. Epub 2020 Dec 17.

Oral Medicine and Laser Surgery Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy.

Several noninvasive diagnostic tools have been developed to aid the early detection of oral cancer and for evaluation before definitive biopsy. Among these, devices evaluating a tissues autofluorescence (AF) are emerging. In particular, the most well known of these is the VELscope system (LED Medical Diagnostics, Inc. Read More

Int J Gynecol Pathol 2020 Dec 14. Epub 2020 Dec 14.

Department of Anatomical Pathology, Vancouver General Hospital and University of British Columbia (J.P., B.T.-C., E.T., N.A., J.H., B.G., L.H.) Department of Molecular Oncology, British Columbia Cancer Research Center (D.H.), Vancouver, British Columbia, Canada.

Recurrent vulvar squamous cell carcinomas (SCCs) are a poorly understood and aggressive group of treatment-resistant neoplasms. Currently, it remains unclear whether these are in fact recurrences of the same primary tumor, or the development of entirely new tumors. Here, to address this question, we examined the mutational profile of a series of patients with recurrent or multifocal non-human papilloma virus (HPV)-associated vulvar SCC. Read More

An Bras Dermatol 2021 Jan-Feb;96(1):103-105. Epub 2020 Nov 20.

Department of Dermatology, Hospital do Servidor Público Estadual de São Paulo, São Paulo, SP, Brazil.

Muir-Torre syndrome is a rare, autosomal dominant genodermatosis, characterized by sebaceous neoplasms and visceral carcinomas. The authors describe the case of a patient who, 16 years after the diagnosis of colon carcinoma, presented a verrucous plaque on the pubic region, histopathologically compatible with sebaceous adenoma. The need to investigate this syndrome is emphasized, especially in cases of sebaceous neoplasms located outside the head, face, and neck. Read More

Hum Pathol 2021 Mar 24;109:12-20. Epub 2020 Nov 24.

Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. Electronic address:

Hemorrhoidectomy specimens serve as an excellent resource for study of incidental anal pathology. Detection of most incidental findings is quite rare, although diagnosing clinically significant lesions can have profound impact on the clinical follow-ups. While there are many case reports of incidental findings in hemorrhoidectomy specimens, there are few large studies focused on this topic. Read More

Cureus 2020 Oct 4;12(10):e10789. Epub 2020 Oct 4.

Internal Medicine, University of Central Florida College of Medicine, Orlando, USA.

Human papillomavirus (HPV) is a widespread sexually transmitted infection which can lead to genital warts, squamous cell carcinoma, and verrucous carcinomas. Buschke-Loewenstein tumor (BLT) is a verrucous carcinoma which occurs in the anogenital and perianal areas. BLT is often associated with HPV 6 and 11, but HPV is preventable through routine vaccination. Read More