Search Our Scientific Publications & Authors

Indian J Dermatol 2018 Nov-Dec;63(6):496-501

Department of Dermatology and STD, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India.

Background: Subcutaneous mycoses, although rare, are frequently reported from northeast India. Their spectrum varies with geographic region.

Materials And Methods: We evaluated clinical records and histopathological features of subcutaneous mycoses cases seen during April 2013 to March 2017. Read More

Int J Surg Case Rep 2018 Nov 27;54:7-9. Epub 2018 Nov 27.

Department of Plastic Surgery and Breast Surgery, Zealand University Hospital, Roskilde, Denmark.

Introduction: Verrucous carcinoma is an uncommon variant of low-grade squamous cell malignancy with a low malignant potential but a high risk of recurrence.

Presentation Of Case: We report a case of a Human Papilloma Virus negative local verrucous carcinoma in the perianal area of a 45-year old otherwise healthy female. The tumor presented clinically as a persistent genital wart not responding to usual dermatologic local therapy. Read More

Cutis 2018 Oct;102(4):223;230;231

Department of Dermatology, Hospital Sultanah Aminah Johor Bahru, Johor, Malaysia.

Am J Dermatopathol 2018 Dec;40(12):937

Department of Dermatology, Medical University of South Carolina, Charleston, SC.

Vet Dermatol 2018 Nov 25. Epub 2018 Nov 25.

Institute of Genetics, Vetsuisse Faculty, University of Bern, Länggassstrasse 120, 3001, Bern, Switzerland.

Background: The feline counterpart of human inflammatory linear verrucous epidermal nevus (ILVEN) has been described; however, the possible underlying developmental defect has not been investigated.

Objective: To report a case of multiple ILVEN-like lesions in a cat with a genetic variant in the NSDHL gene.

Animals: A 2-year-old, female, domestic short hair cat with a history of multiple alopecic, verrucous, hyperpigmented and erythematous skin lesions, following Blaschko's lines on the head, the limbs, the trunk and paw pads. Read More

Pan Afr Med J 2018 28;30:187. Epub 2018 Jun 28.

Service de Dermatologie et de Vénéréologie, CHU Ibn Rochd, Casablanca, Maroc.

We report the case of a 13-year old female patient from rural areas presenting with papulonodular lesion of 4/3cm in the lower third of the right leg, evolving over the last two years. Skin biopsy showed papillomatous hyperplasia with neutrophilic microabscess and spores. Direct mycological examination showed fumagoid bodies and Fonsecaea pedrosoi was isolated from culture. Read More

J Am Acad Dermatol 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology, Boston University School of Medicine, Boston, MA. Electronic address:

Part 2 of this 2-part continuing medical education series discusses the clinical and histopathologic features of common premalignant and malignant lesions of the oral cavity. It is imperative for dermatologists to be able to recognize suspicious lesions, determine biopsy need, counsel, and refer patients presenting with premalignant or malignant conditions appropriately. Given the higher rates of mortality and morbidity of oral mucosal malignancies due to late diagnosis, appropriate treatment with multidisciplinary care in a timely manner is essential to these neoplasms. Read More

Clin Exp Dermatol 2018 Nov 16. Epub 2018 Nov 16.

Dermatology Department, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Clin Microbiol Rev 2018 Jan 14;32(1). Epub 2018 Nov 14.

Servicio de Dermatología y Departamento de Micología, Hospital General de México, Mexico City, Mexico.

SUMMARYHumans encounter mycobacterial species due to their ubiquity in different environmental niches. In many individuals, pathogenic mycobacterial species may breach our first-line barrier defenses of the innate immune system and modulate the activation of phagocytes to cause disease of the respiratory tract or the skin and soft tissues, sometimes resulting in disseminated infection. Cutaneous mycobacterial infections may cause a wide range of clinical manifestations, which are divided into four main disease categories: (i) cutaneous manifestations of infection, (ii) Buruli ulcer caused by and other related slowly growing mycobacteria, (iii) leprosy caused by and , and (iv) cutaneous infections caused by rapidly growing mycobacteria. Read More

Hum Pathol 2018 Nov 10. Epub 2018 Nov 10.

Department of Medicine, Surgical Pathology Unit, University of Padua, Padua, Italy.

Verrucous carcinoma of the esophagus (VCE) is a rare variant of squamous cell cancer, with a puzzling clinical, etiological, and molecular profile. The etiological involvement of human papillomavirus (HPV) in the cancer's natural history is controversial. This study considers nine cases of VCE, focusing on patients' clinical history before surgery, histological phenotype, immunophenotype (EGFR, E-cadherin, cyclin D1, p16, and p53 expression), HPV infection, and TP53 gene mutational status (exons 5-8). Read More

Cureus 2018 Sep 3;10(9):e3244. Epub 2018 Sep 3.

Dermatology, University of Texas Mcgovern Medical School at Houston, Houston, USA.

Verrucous carcinoma (VC) is a rare variant of squamous cell carcinoma (SCC). It is described as a low grade, slow growing, locally infiltrative neoplasm that accounts for 3%-8% of penile SCCs. Here we report a case of destructive VC of the glans penis in a paraplegic man resulting in a hypospadias from the tip of the glans to the corona. Read More

Skinmed 2018 9;16(5):337-339. Epub 2018 Nov 9.

West Bengal Skineplex, Center of Dermatology, Burdwan, West Bengal, India.

A 56-year-old man presented with multiple, skin-colored, raised eruptions of the scrotum that had been present for 2 years. Their onset had been gradual, and they had been increasing in size, resulting in cosmetic disfigurement. A year previously, he had been operated on for a bilateral vaginal hydrocele with partial excision and eversion of the sac (Jabouley method). Read More

Am J Dermatopathol 2018 Oct 30. Epub 2018 Oct 30.

Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston, MA.

Maxillofac Plast Reconstr Surg 2018 Dec 25;40(1):31. Epub 2018 Oct 25.

2Department of Oral and Maxillofacial Surgery, School of Dentistry, Chonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896 South Korea.

Background: Verrucous carcinoma (VC) accounts for 1-10% of cases of squamous cell carcinoma (SCC) in the oral cavity, and 75% of VC occur in the oral cavity. Only 3% of primary intraosseous squamous cell carcinomas (PIOSCC), which means SCC occurring primarily in the bone, are VC. Verrucous carcinoma arising from odontogenic cysts (OC) is very rare, with only seven cases reported to date. Read More

Am J Clin Dermatol 2018 Nov;19(Suppl 1):15-23

Department of Dermatology, Universidad del Desarrollo, Clínica Alemana, Manquehue Norte 1410, Vitacura, Santiago, Chile.

This review presents the main challenges encountered when diagnosing unusual variants of malignant melanoma with the aim of raising awareness to allow application of the most appropriate treatment strategies. Although these melanomas are often rare, their misdiagnosis potentially jeopardizes patients' health and survival, and has medicolegal implications. The clinical and histologic presentations of melanoma vary greatly, and assessment of uncommon melanomas can be difficult for practitioners because of their scarcity and resemblance to other dermatologic entities. Read More

Pan Afr Med J 2018 14;30:132. Epub 2018 Jun 14.

Service de Dermatologie-Vénérologie, Hôpital d'Instruction Mohammed V, Rabat, Maroc.

Sebaceous naevus (sebaceous hamartoma) is a congenital lesion mainly localized to the scalp, whose clinical and histologic diagnosis is generally easy. In the vast majority of cases, it is diagnosed at birth, but it can sometimes go unnoticed and give the impression to occur later. This lesion may be complicated by benign tumors or more rare malignancies. Read More

Cutis 2018 09;102(3):E22-E23

Department of Dermatology, Mount Sinai St. Luke's and Mount Sinai West, New York, New York, USA.

SAGE Open Med Case Rep 2018 10;6:2050313X18802143. Epub 2018 Oct 10.

Division of Dermatology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, AB, Canada.

Condyloma acuminata, also known as anogenital warts, represent a cutaneous infection caused by sexual transmission of the human papilloma virus. We present a case of overwhelming condyloma acuminata that was treated successfully without surgery using only topical imiquimod 3.75% cream. Read More

Pan Afr Med J 2018 29;30:78. Epub 2018 May 29.

Hôpital Civil Tétouan, Tétouan, Maroc.

Epidermodysplasia verruciformis, also known as Lewandowsky-Lutz syndrome or tree man disease is a rare genetic skin disorder. It is characterized by abnormal susceptibility of the skin coating to human papillomaviruses (HPVs). It commonly affects people between the ages of 4 and 8, most often before the age of 20 years but it may exceptionally occur later. Read More

BMJ Case Rep 2018 Oct 17;2018. Epub 2018 Oct 17.

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

A 17-year-old woman presented with moderately itchy, non-progressive, linearly arranged verrucous plaques over dorsum of left foot since early childhood. Two years ago, she developed slowly increasing, verrucous exophytic growth in posterior most aspect of linear verrucous plaque. One year ago, she also developed multiple, linearly arranged, fleshy plaques with surface crusting over lateral aspect of right leg extending to thigh. Read More

JAAD Case Rep 2018 Oct 3;4(9):866-868. Epub 2018 Oct 3.

Department of Dermatology, University of Mississippi Medical Center, Jackson, Mississippi.

JAAD Case Rep 2018 Oct 1;4(9):854-856. Epub 2018 Oct 1.

Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.

Contemp Clin Dent 2018 Sep;9(Suppl 2):S369-S372

Department of Oral Surgery, Consultation Center of Dental Treatments of Rabat, School of Dental Medicine, Mohamed V University, Rabat, Morocco.

Oral papilloma is a benign proliferation of the stratified epithelium, which results in a papillary or verrucous exophytic mass, which can be induced by human papillomavirus. These oral mucosa lesions are most often asymptomatic and have small progression. Laser-assisted surgery is common nowadays with several advantages including successful hemostasis, devoid of sutures, wound sterilization and minimal postoperative pain, and edema. Read More

J Clin Immunol 2018 Oct 28;38(7):794-803. Epub 2018 Sep 28.

Grupo de Inmunodeficiencias Primarias, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia.

Purpose: CARD9 deficiency is an inborn error of immunity that predisposes otherwise healthy humans to mucocutaneous and invasive fungal infections, mostly caused by Candida, but also by dermatophytes, Aspergillus, and other fungi. Phaeohyphomycosis are an emerging group of fungal infections caused by dematiaceous fungi (phaeohyphomycetes) and are being increasingly identified in patients with CARD9 deficiency. The Corynespora genus belongs to phaeohyphomycetes and only one adult patient with CARD9 deficiency has been reported to suffer from invasive disease caused by C. Read More

Indian Dermatol Online J 2018 Sep-Oct;9(5):334-337

Department of Pathology, JSS Medical College and Hospital, JSS University, Mysuru, Karnataka, India.

Locus minoris resistentiae (LMR) is a site of the body that offers lesser resistance than the rest of the body to the onset of disease. It can be congenital or acquired. Areas of cutaneous mosaicism such as epidermal nevi can act as congenital LMR, leading to the development of inflammatory skin conditions or skin tumors on these. Read More

Int J Surg Case Rep 2018 12;51:296-301. Epub 2018 Sep 12.

Special Surgery Department, Faculty of Medicine, University of Jordan, P.O. Box 13857, Amman, 11942, Jordan. Electronic address:

Introduction: Seborrheic keratosis is one of the most common benign epidermal cutaneous lesions encountered by dermatologists and plastic surgeons in their daily practice.

Presentation Of The Case: A 66-year-old man was presented with a large verrucous mass on the sacrum and perianal area of 10 years duration. After the diagnosis of SK was confirmed, a complete excision of the lesion was done with coverage of the defect with a partial thikness skin graft, with a good outcome. Read More

J Am Acad Dermatol 2018 Sep 18. Epub 2018 Sep 18.

Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, PR. China; Department of Laser and Aesthetic Medicine, Shanghai Ninth People's Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, PR. China. Electronic address:

Cutis 2018 Aug;102(2):111-114

Advanced Dermatology Associates LTD; Lehigh Valley Health Network, Allentown, Pennsylvania, USA.

Inflammatory linear verrucous epidermal nevus (ILVEN) is a rare cutaneous disease that presents as linear psoriasiform plaques with associated prominent pruritus. The lesions commonly pre-sent on the legs with onset during childhood. Inflammatory linear verrucous epidermal nevus typically is refractory to treatment. Read More

Pediatr Dermatol 2018 Nov 14;35(6):e378-e381. Epub 2018 Sep 14.

Department of Pathology, Institut Imagine, APHP, Hôpital Universitaire Necker-Enfants Malades, Université Paris Descartes - Sorbonne Paris Cité, Paris, France.

Verrucous hemangioma or verrucous venous malformation is a superficial venous malformation frequently misdiagnosed as a lymphatic malformation because of its classical hyperkeratotic appearance. Clinical characteristics of VVM were studied in patients with a histologically confirmed VVM, and validated in a prospective study of 18 patients. VVM was made of separated vascular elements with irregular shape, in a linear disposition, with variable thickness and keratosis. Read More

Am J Dermatopathol 2018 Sep 11. Epub 2018 Sep 11.

Otorhinolaryngology, Post Graduate Institute of Medical Education & Research, Chandigarh, India.

Phaeohyphomycosis is a rare mycotic infection caused by heterogenous groups of dematiaceous fungi involving the skin and subcutaneous tissue. Here, we report a case of cutaneous phaeohyphomycosis presenting as cauliflower-like verrucous lesion over the face in an immunocompetent individual. Histopathology showed suppurative granulomatous inflammation replete with pigmented broad fungal hyphae which is stained with periodic acid-Schiff stain, Grocott's methanamine silver stain, Schmorl's stain, and Masson-Fontana stain. Read More

J Dtsch Dermatol Ges 2018 Oct 13;16(10):1269-1272. Epub 2018 Sep 13.

Department of Dermatology, Venereology and Allergology, Essen University Medical Center, Essen, Germany.

Pediatr Dermatol 2018 Sep;35(5):671-672

Division of Pediatric Dermatology, Nationwide Children's Hospital and College of Medicine, The Ohio State University, Columbus, OH, USA.

J Vet Med Sci 2018 Nov 12;80(10):1567-1571. Epub 2018 Sep 12.

Division of Pathology and Pathophysiology, National Institute of Animal Health, National Agriculture and Food Research Organization (NARO), 3-1-5 Kannondai, Tsukuba, Ibaraki 305-0856, Japan.

A 5-month-old crossbred beef steer died after exhibiting astasia. A postmortem examination revealed verrucous endocarditis and numerous renal hemorrhages. Gram-positive bacteria were identified in the necrotic lesions of the verruca and mitral valve via histopathological analysis. Read More

Photodiagnosis Photodyn Ther 2018 Sep 8. Epub 2018 Sep 8.

Department of Plastic & Cosmetic Surgery, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, PR China. Electronic address:

Background: Verrucous carcinoma in penis is a rare disease characterized by verrucous lesions. The traditional methods for verrucous carcinoma resulting in loss of sexual function are not satisfactory. The purpose of this study was to evaluate the safety and effect of topical aminolevulinic acid photodynamic therapy in the treatment of verrucous carcinoma in penis. Read More

J Dtsch Dermatol Ges 2018 Nov 11;16(11):1387-1390. Epub 2018 Sep 11.

Department of Dermatology and Allergology, Bremen-Mitte Medical Center, Bremen, Germany.

Arch Pathol Lab Med 2018 Sep 11. Epub 2018 Sep 11.

From the Department of Pathology, University of Michigan Health System, Ann Arbor.

Context: - Histologic distinction between condyloma acuminatum and various benign and malignant condyloma-like lesions in the anogenital area poses a common diagnostic challenge to pathologists across subspecialties.

Objective: - To review the overlapping and distinguishing features of condyloma acuminatum and its mimics, and to clarify confusing terminology and diagnostic criteria for problematic entities.

Data Sources: - A review of the literature on condyloma acuminatum (ordinary and giant types), verrucous carcinoma, warty/warty-basaloid high-grade squamous intraepithelial lesion and squamous cell carcinoma, papillary squamous cell carcinoma, bowenoid papulosis, verruca vulgaris, epidermolytic acanthoma, and verruciform xanthoma was performed. Read More

J Cancer Res Ther 2018 Jul-Sep;14(5):934-940

Department of Radiation Oncology, Silchar Medical College, Silchar, Assam, India.

Context: Head neck cancer (HNCA) in North-East India accounts for 54.48% cancers at all sites, one of the highest in the country. Increased serum lactate dehydrogenase (LDH) activity is considered as a marker of cellular necrosis while serum alkaline phosphatase (ALP) is recognized as an important marker of induction of tumor cell differentiation. Read More

Br J Oral Maxillofac Surg 2018 Nov 3;56(9):780-785. Epub 2018 Sep 3.

Molecular and Clinical Cancer Medicine Department, University of Liverpool Cancer Research Centre.

Proliferative verrucous leukoplakia (PVL) is a potentially premalignant lesion that undergoes malignant transformation in over 40% of cases. Its clinical homogeneity suggests that a single or a small number of molecular pathogenic pathways may exist. Using the Cochrane protocol for systematic reviews, we have looked at the reported evidence of the molecular aetiology and pathogenesis of PVL and compared it with that of conventional oral epithelial dysplasia (OED). Read More

Int J Surg Pathol 2018 Sep 5:1066896918796647. Epub 2018 Sep 5.

1 Brown University, Providence, RI, USA.

Minerva Urol Nefrol 2018 Aug 29. Epub 2018 Aug 29.

Urology Unit, Santa Chiara Hospital, Trento, Italy: 2 Urology Unit, University of Pisa, Pisa, Italy.

Introduction: Human papilloma virus (HPV) is the most common sexually transmitted pathogen and its potential role in the genesis of several diseases such as cervical, head and neck, anal and penile cancers, is now largely recognized. Aim of this review article is evaluate and summarize the state of the art of HPV-related uro-genital cancers, focusing on the potentially innovative methods for the diagnosis of infection that should be used to improve viral causative detection and prevent its diffusion through sexual intercourses.

Evidence Acquisition: The initial search was carried out by using the Medline and the Google Scholar computerized databases through the selected key-words to identify the more recent literature on HPV epidemiology and its relationship with the main relevant urinary tract cancers. Read More

Zhonghua Nan Ke Xue 2018 Janurary;24(1):62-66

Department of Urology, Henan Provincial People's Hospital / People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China.

Objective: To explore the clinicopathological characteristics, diagnosis and treatment of penile verrucous carcinoma (VC).

Methods: We retrospectively analyzed the clinical data about 18 penile VC patients at the mean age of 52 (35－66) years. The tumors were cauliflower-like, measuring 2. Read More

An Bras Dermatol 2018 Sep-Oct;93(5):712-715

Dermatology Department and Public Health Dermatology Outpatient Clinic, Porto Alegre, Rio Grande do Sul State Health Department, Porto Alegre (RS), Brazil.

Verrucous hemangioma is a rare vascular skin disorder with an immune profile similar to vascular neoplasms, but with behavior and evolution of vascular malformations. Its main differential diagnosis is angiokeratoma circumscriptum neviforme, with an almost indistinguishable clinical presentation because both diseases appear as erythematous patches that evolve to violaceous plaques, becoming scaly and even verrucous, most commonly affecting the lower limbs. Histopathology is crucial for the correct diagnosis: while in angiokeratoma the vascular alterations are limited to the papillary dermis, verrucous hemangioma extends deep into the dermis, reaching the subcutaneous tissue. Read More

Front Microbiol 2018 14;9:1806. Epub 2018 Aug 14.

Centre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

Human papillomavirus (HPV) has long been proposed as a cofactor in the pathogenesis of cutaneous squamous cell carcinoma (cSCC). More recently, the striking clinico-pathological features of cSCCs that complicate treatment of metastatic melanoma with inhibitors targeting BRAF mutations (BRAFi) has prompted speculation concerning a pathogenic role for oncogenic viruses. Here, we investigate HPV and human polyomaviruses (HPyV) and correlate with clinical, histologic, and genetic features in BRAFi-associated cSCC. Read More

Int J Clin Pediatr Dent 2018 May-Jun;11(3):244-246. Epub 2018 Jun 1.

Reader, Department of Oral Pathology and Microbiology, Army College of Dental Sciences, Secunderabad, Telangana, India.

Most of the lesions in the oral cavity have papillary appearance. Oral squamous papilloma (SP) is one such type, which is a benign proliferation of the stratified squamous epithelium and presents as papillary or verrucous exophytic mass induced by human papillomavirus (HPV). Most of the oral mucosal lesions are often asymptomatic and have small progression. Read More

J Cosmet Laser Ther 2018 Aug 21:1-3. Epub 2018 Aug 21.

a Department of Dermatology and Venereology, Nanfang hospital , Sourthern Medical University , Guangzhou , PR China.

Verrucous epidermal nevus (VEN) is a skin disorder that commonly presents at birth; it is characterized by skin-colored to brown verrucous papules in a linear distribution following Blaschko's lines. Even though it is extremely rare, VEN has been associated with malignant transformation. VEN has been treated by different treatment modalities with varying and frustrating results. Read More

Indian J Dent Res 2018 Jul-Aug;29(4):525-528

Department of Oral Pathology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.

Carcinoma cuniculatum (CC) is a rare variant of squamous cell carcinoma (SCC). Only 27 cases have been published in English. A 50-year-old male, who presented a white nodule with erythematous areas, localized in the lateral border of the tongue with 2 months of duration. Read More

J Mycol Med 2018 Dec 17;28(4):663-665. Epub 2018 Aug 17.

Departamento de Ecología de Agentes Patógenos, Hospital General Dr. Manuel Gea González, 14080 Tlalpan, Mexico. Electronic address:

Chromoblastomycosis is defined as a chronic cutaneous and subcutaneous fungal infection caused by melanized or brown-pigmented fungi. A 63-year-old man farmer showed on external and internal part of the right arm, a well-delimited verrucous and hyperkeratotic plaque, with atrophic and cicatricial areas. Direct examination of skin scrapings samples showed the presence of muriform cells, a classic feature of chromoblastomycosis. Read More