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Mod Pathol 2020 May 19. Epub 2020 May 19.

Sunnybrook Health Sciences Centre and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.

Verruciform proliferations of the vulva unrelated to HPV infection are rare. The term differentiated exophytic vulvar intraepithelial lesion (DEVIL) was recently proposed for these lesions, which harbor recurrent PIK3CA mutations. It is still unclear whether DEVIL is related to verrucous carcinoma, a neoplasm characterized by persistence and local recurrence but nil risk of distant spread. Read More

Case Rep Oncol Med 2020 25;2020:4674871. Epub 2020 Apr 25.

Department of Clinical Oncology, Hong Kong University Shenzhen Hospital, Shehzhen, China.

This case report describes a 63-year-old female with a locally advanced esophageal carcinoma cuniculatum treated with definitive chemoradiation who had a rapid and early response. This case is illustrative of an aggressive behavior with rapid response and rapid recurrence. The cases of esophageal carcinoma cuniculatum as well as the closely related clinical entity of verrucous carcinoma are reviewed suggesting good clinical outcomes after definitive therapy with chemoradiation and/or surgery. Read More

J Cancer Res Ther 2020 Jan-Mar;16(1):170-172

Department of Dermatology, Netherlands Cancer Institute, Amsterdam, Netherlands.

With the discovery of v-Raf murine sarcoma viral oncogene homolog B (BRAF) inhibitors, new treatment possibilities arose against metastatic melanoma. A frequent adverse effect of BRAF inhibitor therapy is the induction of epithelial proliferations such as cutaneous squamous cell carcinoma and verrucous papilloma. Here, we describe a case in which a patient developed extensive anal epithelial proliferations resembling condylomata acuminata, after starting vemurafenib treatment. Read More

Int J Urol 2020 Jun 19;27(6):538-542. Epub 2020 Apr 19.

Department of Urology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

Objectives: To investigate the clinical characteristics of patients with penile cancer in Japan using the nationwide hospital-based cancer registry database.

Methods: Using hospital-based cancer registry data, we described the distribution of age, pathology, tumor-node-metastases classification, and first-course treatment in patients treated between 2012 and 2015. We compared the patterns of first-line treatment between elderly and non-elderly patients. Read More

Acta Clin Belg 2020 Apr 11:1-5. Epub 2020 Apr 11.

Department of Medical Oncology, Department of Drug Research Unit Ghent, Cancer Research Institute Ghent, Ghent University and Ghent University Hospital, Ghent, Belgium.

: Verrucous hyperplasia (VH) and verrucous carcinoma (VC) of the head and neck are two (pre)malignant entities that are slowly progressive with low tendency to metastasize. However, they can reduce the patient's Quality of Life (QoL) and may even transform into squamous cell carcinoma (SCC). As they are typically approached by surgical resection, some patients do not qualify for surgery. Read More

Am J Dermatopathol 2020 Apr 7. Epub 2020 Apr 7.

Department of Dermatology, Centre Hospitalier Lyon Sud, Pierre Bénite, France.

Proliferating onychomatricoma is a new challenging variant of onychomatricoma that can clinically and histologically mimic squamous cell carcinoma/onycholemmal carcinoma. This is a retrospective case series study of the clinicopathologic and dermoscopic features of 6 patients with a pathologic diagnosis of proliferating onychomatricoma, which was conducted in the dermatology and dermatopathology departments of 2 university hospitals and a private nail's dermatology consultation. The clinical, histological, and immunohistochemical features and follow-up of 6 patients with proliferating onychomatricoma were analyzed; we compare our finding with 6 cases of conventional onychomatricoma. Read More

North Clin Istanb 2020 2;7(2):187-191. Epub 2019 Jul 2.

Department of Pathology, Health Sciences University, Umraniye Training and Research Hospital, Istanbul, Turkey.

Epithelial-myoepithelial carcinoma is a biphasic low-grade malignant tumor, which represents approximately 1% of all salivary gland tumors. This tumor occurs mostly in the parotid gland, followed by submandibular gland and minor salivary glands. Women, mostly fifth to the eighth decade of life, are commonly affected. Read More

Am J Surg Pathol 2020 Mar 31. Epub 2020 Mar 31.

Pathology and Research Institute and Medical Sciences of National University of Asuncion, Asunción, Paraguay.

Penile cancer and its precursor lesions are morphologically and clinically heterogenous and they can be further characterized by immunohistochemical (IHC) and molecular genetic analyses. According to the current World Health Organization (WHO) classification, penile intraepithelial neoplasia (PeIN) and invasive penile carcinomas can be grouped into human papillomavirus (HPV)-related and non-HPV-related neoplasms. This distinction is clinically relevant for etiological and prognostic reasons. Read More

Mod Pathol 2020 Mar 20. Epub 2020 Mar 20.

Department of Anatomical Pathology, Vancouver General Hospital, Vancouver, BC, Canada.

The recent literature has shown that vulvar squamous cell carcinoma (VSCC) can be stratified into two prognostically relevant groups based on human papillomavirus (HPV) status. The prognostic value of p53 for further sub-stratification, particularly in the HPV-independent group, has not been agreed upon. This disagreement is likely due to tremendous variations in p53 immunohistochemical (IHC) interpretation. Read More

Int J Colorectal Dis 2020 Mar 17. Epub 2020 Mar 17.

Division of Hand, Plastic and Aesthetic Surgery, University Hospital, LMU Munich, Pettenkoferstr. 8a, 80336, Munich, Germany.

Background: Crohn's disease (CD) is a chronic inflammatory disorder which leads to anorectal fistulas. In rare cases, patients develop anal squamous cell carcinoma (ASCC) within these lesions. There is limited literature regarding ASCC in patients with CD. Read More

Gan To Kagaku Ryoho 2019 Dec;46(13):2185-2188

Division of Oral and Maxillofacial Surgery, Oki Hospital.

In recent years, the opportunity to treat oral cancer in elderly patients has been increasing because of the increased lifespan of individuals. Standard treatment for advanced tongue cancer involves reconstruction of the tongue with a free vascularized flap. However, this may not always be suitable for elderly patients because the procedure is lengthy and invasive and also because of their medical history. Read More

J Dermatol 2020 May 5;47(5):e188-e190. Epub 2020 Mar 5.

Department of Skin Oncology/Dermatology, Saitama Medical University International Medical Center, Hidaka, Japan.

Biotech Histochem 2020 Mar 3:1-6. Epub 2020 Mar 3.

National Atomic Energy Commission (CNEA), Argentina.

The epithelium adjacent to an oral squamous cell carcinoma is at risk of undergoing precancerous changes. Even after such changes occur, however, the adjacent epithelium remains histologically similar to normal mucosa. We investigated five argyrophilic nucleolar organizer region (AgNOR)-related features in samples of oral verrucous carcinoma (VeCa) and their corresponding adjacent lining epithelium (adj. Read More

Case Rep Otolaryngol 2020 31;2020:7134789. Epub 2020 Jan 31.

Otorhinolaryngology Head and Neck Surgery, National Academy of Medical Sciences, Bir Hospital, Kathmandu, Nepal.

Background: A cutaneous horn is a common clinical entity which usually presents as a cutaneous lesion. Because of its subtle nature, patients usually tend to present late unless the lesion is big or complications develop. Because of its resemblance to animal horn, it has been given the term "horn. Read More

Methods Mol Biol 2020 ;2129:7-18

Cancer Molecular Pathology, School of Medicine, Griffith University, Gold Coast, Queensland, Australia.

Histological assessment of esophageal squamous malignancies is crucial for management of patients with the cancer as well as working in research on the cancer. The squamous malignancies in the esophagus comprise squamous dysplasia and squamous cell carcinoma. Current classification of squamous dysplasia in the esophagus is to divide it into low grade and high grade. Read More

Int J Surg Pathol 2020 Feb 11:1066896920903388. Epub 2020 Feb 11.

Queen Victoria Hospital NHSF Trust, East Grinstead, West Sussex, UK.

Cystic squamous cell carcinomas (SCCs) of the jaws, including carcinoma cuniculatum, are rare, slow growing, and relentlessly invasive. The aim of this article is to present 12 cases, 4 of which were designated as carcinoma cuniculatum on the basis of deeply endophytic, anastomosing channels of cystic stratified squamous epithelium and keratin microabscesses. The other 8 were also cystic, but more heterogeneous morphologically and were diagnosed as well differentiated SCCs. Read More

Oral Dis 2020 Feb 11. Epub 2020 Feb 11.

Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy.

Biological tissues (including oral mucosa) can absorb and re-emit specific light wavelengths, detectable through spectrophotometric devices. Such a phenomenon is known as "autofluorescence" (AF). Several devices evaluating tissue AF have been developed and commercialized in the last two decades. Read More

Surg Case Rep 2020 Feb 7;6(1):35. Epub 2020 Feb 7.

Department of Digestive Surgery and Transplantation Surgery, Tokyo Medical University Hachioji Medical Center, 1163 Tatemachi, Hachioji, Tokyo, 193-0998, Japan.

Background: Verrucous carcinoma is an extremely rare form of cancer in the esophagus.

Case Presentation: A 56-year-old woman presented with dysphagia in 2007. Endoscopic examination revealed an irregular protruding circumferential erosion in the lower thoracic esophagus, but because pathological examination of the biopsy specimen showed no evidence of malignancy, the status of the erosion was followed up by an upper gastrointestinal endoscopic examination every 3 months. Read More

J Oral Maxillofac Pathol 2019 Sep-Dec;23(3):393-399

Department of Oral Pathology, Nair Hospital Dental College, Mumbai, Maharashtra, India.

Introduction: The present study analyzed the occurrence of exophytic verrucous hyperplasia (EVH) in the background of oral submucous fibrosis (OSF), which presents clinically as a solitary verrucopapillary lesion (VPL) mimicking malignancy. We also aimed to obtain additional information on VELscope appearance and histopathological features of EVH.

Materials And Methods: The prevalence of EVH in OSF background was assessed from January 2014 to December 2018 using VELscope and histopathological examination. Read More

Medicine (Baltimore) 2020 Jan;99(2):e18660

School of Nursing, Hubei University of Science and Technology, Xianning, China.

Verrucous carcinoma is a rare variant of squamous cell carcinoma. The oral cavity, genitals, larynx, esophagus, and skin are usually affected, and the head and neck regions are the most affected areas. Few studies reported about head and neck verrucous carcinoma (VC) in the literature. Read More

Open Access Maced J Med Sci 2019 Sep 19;7(18):3061-3063. Epub 2019 Aug 19.

Department of Dermatology, University of Rome "G. Marconi", Rome, Italy.

Background: Cutaneous squamous cell carcinoma (SCC) is the second most common malignancy of skin. Although a major risk factor is a chronic exposure to ultraviolet radiation, preexistent chronic inflammatory disorders may also possess an increased risk for SCC. That is not the case for cutaneous lichen planus in contrast to oral lichen planus and oral SCC. Read More

Skin Appendage Disord 2019 Nov 5;5(6):370-373. Epub 2019 Jun 5.

Department of Dermatology of Military Hospital, Tunis, Tunisia.

Verrucous carcinoma (VC) of the nail bed is a rare variant of squamous cell carcinoma that is often misdiagnosed as a benign condition. The clinical presentation of this tumor is very similar to that of warts or onychomycosis hence the delayed appropriate treatment. Its association with human papillomavirus (HPV) infection has rarely been reported. Read More

Case Rep Pathol 2019 22;2019:1783758. Epub 2019 Oct 22.

Medical Director-Dermpath Diagnostics Bay Area of Dermatopathology, Tampa, FL, USA.

This case report presents a case in which a collision tumor consisting of three separate pathological entities-a verrucous carcinoma (VC), syringocystadenoma papilliferum (SCAP), and a basal cell carcinoma (BCC). The presentation of this collision tumor is unexpected. It presented as an exophytic mass on the scalp. Read More

Ear Nose Throat J 2019 Nov 24:145561319871712. Epub 2019 Nov 24.

Department of Pathology, Southern California Permanente Medical Group, Woodland Hills Medical Center, Woodland Hills, CA, USA.

J Am Podiatr Med Assoc 2019 Nov;109(6):471-476

Verrucous skin lesions on the feet of diabetic patients in conjunction with a neuropathic foot ulcer is an uncommon incident. Currently, there are approximately 20 reported cases in the literature. Herein we report two cases of verrucous lesions superimposing a chronic diabetic ulcer. Read More

Virchows Arch 2020 Apr 15;476(4):543-550. Epub 2019 Nov 15.

Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, USA.

Buschke-Löwenstein tumor (BLT) is a rare sexually transmitted disease, mostly described in clinical literature as case reports or small series. Here, we investigated the clinicopathologic features of BLT in a total of 38 cases retrieved from multiple academic institutions. The average age was 47. Read More

Clin Gastroenterol Hepatol 2019 Nov 8. Epub 2019 Nov 8.

Department of Gastroenterology, Portuguese Oncology Institute of Coimbra, Coimbra, Portugal.

Geriatrics (Basel) 2019 Nov 7;4(4). Epub 2019 Nov 7.

Department of Endocrinology, Diabetology and Geriatrics, Stuttgart General Hospital, 70374 Bad Cannstatt, 24 Prießnitzweg, Germany.

An imbalance of regeneration and destruction of the extracellular matrix due to a plethora of chemo- and cytokines, elevated matrix metalloproteinases, bacterial contamination and repetitive painless tissue damage can lead the chronicity of a wound, especially in diabetic foot ulcers (DFU). Along general lines, wound healing and cancer development are similar. Therefore chronic wounds prepare a breeding ground for cancer development. Read More

Medicine (Baltimore) 2019 Nov;98(45):e17883

Rigvir.

Rationale: Of all the parts of the larynx, the glottis has the highest frequency of cancer. With disease progression, the vocal cord movement is affected and for advanced stages its anatomical and functional preservation is rarely achievable, if at all.

Patient Concerns: Here we describe a 72-year-old patient who presented with hoarseness for a year and was only able to whisper. Read More

Pathol Res Pract 2019 Dec 25;215(12):152670. Epub 2019 Sep 25.

Rambam medical center, Department of pathology, HaAliya HaShniya St 8, Haifa, 3109601, Haifa, Israel; Technion school of medicine, HaAliya HaShniya St 8, Haifa, 3109601, Haifa, Israel.

Objective: Proliferative verrucous leukoplakia is classified as a potentially malignant disorder because of its high rate of malignant transformation. PVL progresses in a series of clinical stages where the early stage represents multiple, multifocal leukoplakias with a high recurrence rate. The intermediate and late stages are clinically exophytic lesion, diagnosed microscopically as verrucous hyperplasia that often progresses into verrucous carcinoma and/or squamous cell carcinoma. Read More

Curr Health Sci J 2019 Apr-Jun;45(2):235-240. Epub 2019 Jun 30.

Department of Pathology, Emergency County Hospital, Craiova, University of Medicine and Pharmacy of Craiova, Romania.

Introduction: The verrucous carcinoma is a type of squamous carcinoma that is highly differentiated, relatively uncommon, locally aggressive, with slow growth and minimal metastatic potential.

Clinical Case: A 48-year old man was admitted to the Dermatology department of the Craiova Hospital for a round-oval tumoral mass that was hyperkeratotic, with central ulceration, covered by a hematic crust, approximately 1.5cm in size, localized at the distal phalanx of the third finger left hand, with perilesional edema and erythema. Read More

J Stomatol Oral Maxillofac Surg 2019 Oct 11. Epub 2019 Oct 11.

Department of Oral and Maxillofacial Surgery, université d'Auvergne, NHE, CHU de Clermont-Ferrand, 1, place Lucie-Aubrac, 63000 Clermont-Ferrand, France; UMR Inserm/UdA, U1107, Neuro-Dol, Trigeminal Pain and Migraine, 2, rue de Braga, 63100 Clermont-Ferrand, France. Electronic address:

Intraosseous verrucous carcinoma of the mandible is a rare situation often confused with chronic osteomyelitis. Despite the low aggressively of the tumor, prognosis is poor because of delayed diagnosis. We report 3 cases, from three different hospitals, initially diagnosed with a chronic osteomyelitis of the mandible after wisdom extraction. Read More

Arch Pediatr 2019 Nov 10;26(8):473-474. Epub 2019 Oct 10.

Department of Dermatology, Ibn Rochd UHC, 1, quartier des hopitaux, 20000, Casablanca, Morocco.

Giant condyloma acuminatum is rare in infants. We report a case of giant perianal condyloma in a 10-month-old infant without sexual abuse. The patient was treated by surgical excision associated with electrocoagulation with no recurrence after 2 years. Read More

Cutis 2019 Aug;104(2):E34-E36

Department of Pathology, Cerrahpas¸a Medical Faculty, University of Istanbul, Turkey.

Head Neck 2020 Jan 7;42(1):67-76. Epub 2019 Oct 7.

Department of Oral and Maxillofacial Surgery, Chang-Chung Memorial Hospital, Kaohsiung, Taiwan.

Background: Although survival rate and quality of life are improved if patients with oral carcinoma can be detected early, however, such lesions are usually asymptomatic; therefore, it is hard to raise awareness. Screening has proved to be cost-effective for early detection.

Methods: Sixty-two patients with oral carcinomas and 555 patients with oral potentially malignant disorders (OPMDs) who were detected through screening were examined the relationship between clinicopathological features and follow-up outcomes. Read More

Biomark Cancer 2019 16;11:1179299X19861957. Epub 2019 Sep 16.

Department of Bioinformatics and Biostatistics, National University Research Institute, National University, Khartoum, Sudan.

Aim: Verrucous carcinoma (VC) is a low-grade rare variant of squamous cell carcinoma (SCC). Syndecan-1 (CD138) is a heparan sulfate proteoglycan which participates in cell-to-cell adhesion and cell-matrix interaction. Being misled by the apparent non-aggressive nature of VC, some clinicians and pathologists believe that this tumor is not an aggressive tumor, not realizing the fact that some of these lesions may contain nests or foci of well-differentiated SCC. Read More

Int J STD AIDS 2019 10 24;30(11):1136-1139. Epub 2019 Sep 24.

Skin Institute & School of Dermatology (SISD), New Delhi, India.

Am Fam Physician 2019 09;100(6):367-368

Naval Medical Center Camp Lejeune Family Medicine Residency, Jacksonville, NC, USA.

J Oral Maxillofac Pathol 2019 May-Aug;23(2):303

Department of Prosthodontics, Sri Rajiv Gandhi College of Dental Sciences, Bengaluru, Karnataka, India.

Objective: The purpose of this study is to identify a co-relation between clinical and histopathological features of verrucous carcinoma.

Materials And Methods: This study was conducted based on Knowledge Attitude and Practice (KAP) questionnaire comprising of 3 sets of questions covering clinical and histopathological aspects of the oral verrucous carcinoma. The target subjects were specialists in the field of Oral Medicine and Radiology, Oral and Maxillofacial Surgery and Oral Pathology. Read More

Clin Colon Rectal Surg 2019 Sep 22;32(5):386-393. Epub 2019 Aug 22.

Department of Colorectal Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, Ohio.

Anal cancer is a heterogeneous and rare disease process that accounts for ∼1.5% of all gastrointestinal tract malignancies. The perianal skin plays host to a variety of different premalignant and malignant lesions, all with variable histology, treatment options, and prognosis. Read More

Pan Afr Med J 2019;33:93. Epub 2019 May 28.

Department of Orthopaedics and Traumatology, Military Hospital Moulay Ismail, BP 50000 Meknes, Morocco.

Heliyon 2019 Aug 26;5(8):e02356. Epub 2019 Aug 26.

Health Care Global Enterprises Ltd, Bangalore 560027, #8 Kalinga Rao Road, Sampangi Ram Nagar, India.

Cutaneous squamous cell carcinoma is a common global cancer with Ultraviolet light recognized as the most significant risk factor. The other definite or plausible risk factors include immunosuppression, infection with oncogenic viruses, exposure to toxins, chemicals, chronic inflammatory skin disease and a high body mass index. This case highlights the rarity of the pathology in terms of size, the subtle transition of verrucous hyperplasia to cutaneous squamous cell carcinoma over a period of time and the fallibility of the frozen section report in deciding the optimum resection margins. Read More

Dermatology 2020 30;236(2):143-144. Epub 2019 Aug 30.

Department of Public Finance and Financial Law, Faculty of Law, University of Bialystok, Drohiczyn Eclesiastical Society of Arts and Sciences, Department of Public Finances, Bialystok, Poland.

A fine and fair depiction of basal cell carcinoma is documented with great fidelity in "Caricature" by Bartolomeo Passerotti (1529-1592). The cancer is pearly white and contains an elevated centre with a sharp and somewhat depressed outline due to ulceration of the lesion. The painting is of essential didactic worth for practicing medical doctors. Read More

Pathol Res Pract 2019 Oct 17;215(10):152602. Epub 2019 Aug 17.

Thoracic Surgery Unit, Department of Surgery, Sapienza University of Rome, Rome, Italy.

Background And Aims: Carcinoma cuniculatum (CC) is a rare variant of an extremely well-differentiated squamous cell carcinoma. The most commonly involved site is the skin, with a preference for the sole. Only 15 cases of esophageal CC have been reported so far. Read More

J Coll Physicians Surg Pak 2019 Sep;29(9):888-890

Department of Dermatology, Pak Emirates Military Hospital, Rawalpindi, Pakistan.

Acanthosis nigricans is a skin disease characterised by symmetric velvety hyperpigmented, verrucous plaques of the intertriginous surfaces of the axilla, neck, inframammary, and mucocutaneous regions. Malignant acanthosis nigricans is a paraneoplastic phenomenon most commonly associated with gastric adenocarcinoma. Tripe palms, florid cutaneous papillomatosis and oral involvement along with generalised acanthosis nigricans are the features which are highly suggestive of internal malignancy. Read More

J Cutan Pathol 2020 Jan 4;47(1):12-16. Epub 2019 Sep 4.

Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.

The association of syringocystadenoma papilliferum (SCAP) with verrucous carcinoma (VC) of the skin in the same lesion is a rare, but well-documented event. Although human papillomaviruses (HPV) have been proposed to have an etiologic role in the development of the verrucous proliferations associated with SCAP, most of the immunohistochemical and molecular studies have failed to show the presence of their genomic material in these lesions. We report a series of four cases of SCAP associated with VC in anogenital lesions. Read More

Clin Oral Investig 2020 Jun 22;24(6):1963-1969. Epub 2019 Aug 22.

Oral Medicine, Valencia University, Valencia, Spain.

Objectives: To describe the number of second primary malignancies in a series of 33 patients with proliferative verrucous leukoplakia (PVL), detailing the mean time between primary malignancies and their clinical characteristics.

Materials And Methods: Two groups of patients were included in this study: group 1 comprised 33 PVL patients who had developed ≥ 2 oral squamous cell carcinoma (OSCC) and group 2 comprised 48 PVL patients without malignant degeneration. We compared the groups with regard to age, gender, oral location, and number of oral sites affected. Read More

JAAD Case Rep 2019 Aug 5;5(8):723-725. Epub 2019 Aug 5.

Department of Dermatology, Walter Reed National Military Medical Center, Bethesda, Maryland.

Int Dent J 2019 Dec 12;69(6):428-435. Epub 2019 Aug 12.

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Khartoum, Khartoum, Sudan.

Objectives: To analyse the clinical and histopathological features of oral leukoplakia (OL) in the Sudan, and to identify the risk factors associated with dysplastic and malignant changes.

Methods: Records of 117 cases with the diagnosis of OL at the Department of Oral Pathology in the period from 2010 to 2017 were reviewed.

Results: Of the 117 cases included in this study, 30 cases (25. Read More

Surg J (N Y) 2019 Jul 5;5(3):e69-e75. Epub 2019 Aug 5.

Department of Otolaryngology, San Paolo Hospital, University of Milan, Milan, Italy.

 Because of its affinity for water-based tissues, carbon dioxide (CO ) laser has become an instrument of choice for treating oral mucosa conditions, ranging from inflammatory to malignant lesions. The aim of this work is to systematically evaluate the outcomes of laser surgery over a wide range of lesions, while providing a solid and reproducible protocol for CO laser surgery in the outpatient management of oral lesion.  Seventy-eight patients underwent 92 laser outpatient procedures for treatment of a wide range of benign and malignant lesions. Read More