Search Our Scientific Publications & Authors

Cureus 2022 Mar 17;14(3):e23248. Epub 2022 Mar 17.

Department of Surgery, Saint Louis University School of Medicine, St. Louis, USA.

A 63-year-old male with a 20-year history of a chronic, recurrent sacrococcygeal pilonidal cyst was referred to our outpatient clinic. He had received multiple surgical resections in the past with benign pathology. He presented with a verrucous wart-like midline mass on the superior gluteal cleft that had grown since his last resection. Read More

Curr Health Sci J 2021 Oct-Dec;47(4):602-607. Epub 2021 Dec 31.

Department of Surgery University of Medicine and Pharmacy of Craiova, Romania.

Verrucous carcinoma is a histopathological type of well-differentiated squamous cell carcinoma, clinically characterized by slow and continuous growth, having a local destructive character, but low metastasis potential. Condyloma acuminatum is a sexually transmitted infection caused mainly by subtypes 6 and 11 of HPV, with subtypes 16, 18 being involved in malignant transformation. We present the case of a 70-year-old woman, hospitalized for a vulvar and perineal vegetative, ulcerated, bleeding tumor, with onset 20 years ago. Read More

Mod Pathol 2022 Apr 18. Epub 2022 Apr 18.

Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Vulvar squamous cell carcinomas and their precursors are currently classified by the World Health Organization based on their association with high-risk human papillomavirus (HPV). HPV independent lesions often harbor driver alterations in TP53, usually seen in the setting of chronic vulvar inflammation. However, a group of pre-invasive vulvar squamous lesions is independent from both HPV and mutant TP53. Read More

Case Rep Dermatol Med 2022 7;2022:9139213. Epub 2022 Apr 7.

UNC School of Medicine Asheville, Asheville, NC, USA.

While rare, cutaneous SCC in patients with darker Fitzpatrick skin types is essential to identify and investigate early and can have a myriad of clinical presentations. While clinical history-taking of suspicious skin lesions is often symptom-driven, other key patient history components, such as surgical history, are often overlooked. Differentiating, prioritizing, and risk-stratifying hyperkeratotic, verrucous papules in patients with darker Fitzpatrick skin types is an essential clinical skill for clinicians to develop to serve an increasingly diverse patient population. Read More

J Cancer Res Ther 2022 Jan-Mar;18(1):266-269

Department of Oral and Maxillofacial Pathology, Sree Mookambika Institute of Dental Sciences, Kanyakumari, Tamil Nadu, India.

Oral carcinoma cuniculatum (OCC) is a rare and distinct clinicopathological variant of oral squamous cell carcinoma (OSCC). The term cuniculatum was derived from a Latin word "cuniculus" meaning burrow, because of the "rabbit burrow" appearance. As it invades the underlying tissue, it forms crypts filled with keratin that are essential in distinguishing this neoplasm from other variants of squamous cell carcinoma (SCC). Read More

Mod Pathol 2022 Mar 31. Epub 2022 Mar 31.

Unit of Oral & Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK.

Oral epithelial dysplasia (OED) is a precursor state usually preceding oral squamous cell carcinoma (OSCC). Histological grading is the current gold standard for OED prognostication but is subjective and variable with unreliable outcome prediction. We explore if individual OED histological features can be used to develop and evaluate prognostic models for malignant transformation and recurrence prediction. Read More

BJU Int 2022 04;129(4):457-459

Department of Urology, Aarhus University Hospital, Aarhus, Denmark.

Head Neck Pathol 2022 Mar 21;16(1):54-62. Epub 2022 Mar 21.

Department of Oral Pathology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka.

The fifth chapter of the upcoming fifth edition of the 2022 World Health Organization Classification of Tumours of the Head and Neck titled Tumours of the oral cavity and mobile tongue, has had some modifications from the 2017 fourth edition. A new section "Non-neoplastic Lesions", introduces two new entries: necrotizing sialometaplasia and melanoacanthoma. The combined Oral potentially malignant disorders and Oral epithelial dysplasia section in the 2015 WHO has now been separated and submucous fibrosis and HPV-associated dysplasia are also discussed in separate sections. Read More

J Med Case Rep 2022 Mar 18;16(1):116. Epub 2022 Mar 18.

Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon.

Background: Buschke-Löwenstein tumor is a giant condyloma acuminata infection that is characterized by degeneration, invasion, and recurrence. It is associated with human papilloma virus infection. It develops around the genital and perineal area, sometimes causing a large budding ulcerated lesion. Read More

J Obstet Gynaecol Can 2022 Mar;44(3):294-297

Allan Blair Cancer Centre, Regina, SK.

Giant condyloma acuminatum (GCA) is a benign anogenital lesion caused by human papilloma virus. It is rarely found on the cervix and is difficult to differentiate from malignancy. It is associated with a propensity for invasion, recurrence, and malignant transformation. Read More

J Clin Transl Res 2022 Feb 25;8(1):80-85. Epub 2022 Jan 25.

Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune, Maharastra, India.

Background And Aim: Cancer-associated fibroblasts (CAFs) are among the key tumor microenvironment components that determine tumor invasion, progression, and resistance to cancer therapeutics. Histologically normal mucosa adjacent to oral squamous cell carcinoma (OSCC) has been shown to harbor CAFs which aid in the loco-regional recurrence of the lesion. Verrucous carcinoma (VC), a low-grade variant of squamous cell carcinoma, has a better clinical outcome. Read More

Cureus 2022 Jan 26;14(1):e21634. Epub 2022 Jan 26.

Hematology/Oncology, Henry Ford Health System, Detroit, USA.

Blastomycosis is caused by , a dimorphic fungus that primarily causes pulmonary disease. Cutaneous blastomycosis is infrequent and tends to be misdiagnosed given its similar presentation to other cutaneous fungal infections and malignancies. A 51-year-old woman presented with a two-month history of disfiguring nasal lesions. Read More

Oncol Rep 2022 Apr 25;47(4). Epub 2022 Feb 25.

Department of Oral Pathology and Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700‑8525, Japan.

Stromal cells in the tumor microenvironment (TME) can regulate the progression of numerous types of cancer; however, the bone invasion of oral squamous cell carcinoma (OSCC) has been poorly investigated. In the present study, the effect of verrucous SCC‑associated stromal cells (VSCC‑SCs), SCC‑associated stromal cells (SCC‑SCs) and human dermal fibroblasts on bone resorption and the activation of HSC‑3 osteoclasts were examined by hematoxylin and eosin, AE1/3 (pan‑cytokeratin) and tartrate‑resistant acid phosphatase staining. In addition, the expression levels of matrix metalloproteinase (MMP)9, membrane‑type 1 MMP (MT1‑MMP), Snail, receptor activator of NF‑κB ligand (RANKL) and parathyroid hormone‑related peptide (PTHrP) in the bone invasion regions of HSC‑3 cells were examined by immunohistochemistry. Read More

Oral Dis 2022 Feb 24. Epub 2022 Feb 24.

Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.

Objective: This study aimed to evaluate prognostic outcomes of PVL-derived oral squamous cell carcinomas (P-OSCC) based on recurrence, new primary tumour, metastasis and survival information.

Study Design: Five databases and grey literature were searched electronically with the following main keywords (proliferative verrucous leukoplakia, squamous cell carcinoma and malignant transformation) to answer the following review question: 'Are survival outcomes for P-OSCC worse?' based on the PECOS principle. The Joanna Briggs Institute Critical Appraisal tool was used to identify possible biases and assess the quality of each of the primary studies. Read More

Photodiagnosis Photodyn Ther 2022 Feb 19;38:102763. Epub 2022 Feb 19.

Department of Dermatology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China; Institute of Dermatology, Jiangxi Academy of Clinical Medical Sciences, Nanchang, Jiangxi, China. Electronic address:

Tuberculosis verrucosa cutis (TBVC) is a rare type of cutaneous tuberculosis, which often occurs in the body with good immunity to tuberculosis bacilli. It usually presents as a hyperkeratotic verrucous plaque with polygonal boarders but can mimic or evolved into other dermatosis such as verruca vulgaris, chromoblastomycosis, hyperkeratotic lupus vulgaris, hypertrophic lichen planus, or squamous cell carcinoma, leading to delayed diagnosis. Here, we reported that a 62-year-old patient diagnosed by TBVC with fester as primary manifestation. Read More

Mod Pathol 2022 Feb 19. Epub 2022 Feb 19.

Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, 02115, USA.

The aim of this multicenter retrospective study is to characterize the histopathologic features of initial/early biopsies of proliferative leukoplakia (PL; also known as proliferative verrucous leukoplakia), and to analyze the correlation between histopathologic features and malignant transformation (MT). Patients with a clinical diagnosis of PL who have at least one biopsy and one follow-up visit were included in this study. Initial/early biopsy specimens were reviewed. Read More

Cancer Rep (Hoboken) 2022 Jan 24:e21591. Epub 2022 Jan 24.

Department of Radiation Oncology, University of Louisville, Louisville, Kentucky, USA.

Background: Verrucous vulvar carcinoma (VC) is an uncommon and distinct histologic subtype of squamous cell carcinoma (SCC). The available literature on VC is currently limited to case reports and small single institution studies.

Aims: The goals of this study were to analyze data from the National Cancer Database (NCDB) to quantitate the incidence of VC and to investigate the effects of patient demographics, tumor characteristics, and treatment regimens on overall survival (OS) in women with verrucous vulvar carcinoma. Read More

JAAD Case Rep 2022 Feb 29;20:54-57. Epub 2021 Dec 29.

Section of Dermatology, Department of Medicine, The University of the West Indies, Mona Campus, Mona, Jamaica.

Int J Oral Maxillofac Surg 2022 Jan 19. Epub 2022 Jan 19.

Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Goldschleger School of Dental Medicine, Tel-Aviv University, Tel-Aviv, Israel; Institute of Pathology, Rabin Medical Center, Petah-Tikva, Israel. Electronic address:

A retrospective clinicopathological analysis was performed to compare 35 proliferative verrucous leukoplakia (PVL), 40 leukoplakia without dysplasia (LK), 48 oral lichen planus (OLP)/oral lichenoid lesions (OLL), and 11 verrucous carcinoma (VC) (N = 134). The PVL group comprised 24 female and 11 male patients (mean age 66.5 years), with two to six sites involved (mean 3. Read More

Head Neck 2022 04 22;44(4):E16-E24. Epub 2022 Jan 22.

The Thyroid, Head and Neck Cancer (THANC) Foundation, New York, New York, USA.

Background: Oral carcinoma cuniculatum (OCC) is a rare, locally aggressive tumor, which tends to invade underlying bone. We present two cases of OCC, one demonstrating invasion of the mandible and the other limited to the tongue.

Methods: An 87-year-old male presented with a right-sided buccogingival lesion. Read More

Medicine (Baltimore) 2022 Jan;101(3):e28664

Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Busan, Republic of Korea.

Rationale: Cervical cancer complicated by irreducible complete uterine prolapse in elderly patients is extremely rare. No standard treatment has been established for these conditions.

Patient Concerns: A 74-year-old woman with a 30-year history of pelvic organ prolapse presented with irreducible complete uterine prolapse and a large exophytic mass involving the cervix and vaginal wall. Read More

Gan To Kagaku Ryoho 2021 Dec;48(13):2094-2097

Dept. of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine.

The Department of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine, has been conducting mass screening of oral cancer using oral abrasion cytology by oral surgeons in eastern Shimane prefecture for public awareness and its early detection. As a result, 3(0.09%)cases of oral cancer were identified. Read More

J Egypt Natl Canc Inst 2022 Jan 17;34(1). Epub 2022 Jan 17.

Oral & Maxillofacial Pathology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt.

Background: Oral carcinoma cuniculatum (OCC) is an unacquainted well-differentiated subtype of oral squamous cell carcinoma, which displays unique clinic-pathological features. Up to date, OCC remains rare with about 75 reported cases, and is frequently missed or even misdiagnosed.

Case Presentation: The aim of the present work was: to report a case of OCC in mandibular gingiva and to highlight its main clinic-pathological diagnostic features: with an exophytic cobble-stone surface and a characteristic endophytic burrowing architecture, as well as to differentiate between it and other closely similar lesions including verrucous carcinoma, papillary squamous cell carcinoma, and well-differentiated conventional oral squamous cell carcinoma. Read More

Foot Ankle Spec 2022 Jan 12:19386400211070431. Epub 2022 Jan 12.

Department of Orthopaedic Surgery and Rehabilitation, The University of Texas Medical Branch, Galveston, Texas (OO, VKP); Department of Plastic Surgery, The University of Texas Medical Branch, Galveston, Texas (WBN); and Department of Internal Medicine, The University of Texas Medical Branch, Galveston, Texas (MR).

Verrucous carcinoma is a rare form squamous cell carcinoma which appears similar to a wart. When it occurs in the feet, it can be easily misdiagnosed. It rarely metastasizes or recurs posttreatment. Read More

Cancers (Basel) 2021 Dec 28;14(1). Epub 2021 Dec 28.

Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8525, Japan.

Tumor stromal components contribute to tumor development and invasion. However, the role of stromal cells in the contribution of bone marrow-derived cells (BMDCs) in oral squamous cell carcinoma (OSCC) invasion is unclear. In the present study, we created two different invasive OSCC patient-derived stroma xenografts (PDSXs) and analyzed and compared the effects of stromal cells on the relation of BMDCs and tumor invasion. Read More

Acta Dermatovenerol Croat 2021 Dec;29(3):169-170

Diego Abbenante, MD, Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Bologna, Via Massarenti 1, 40100, Bologna, Italy;

Dear Editor, A 45-year-old man presented with a large, dark, keratotic, warty, and friable plaque on the distal posterior aspect of the left leg (Figure 1, a). The patient reported that the lesion was not present at birth but had appeared approximately at the age of three as an erythematous patch that progressively grew over the time. During adolescence, the surface of the lesion became rough and warty and was easily traumatized due to its location, resulting in recurrent bleeding episodes over a period of years. Read More