2,001 results match your criteria Verrucous Carcinoma


A first case of primary gastric verrucous carcinoma with isolated squamous epithelium in the stomach.

Virchows Arch 2019 Feb 13. Epub 2019 Feb 13.

Department of Pathology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 3-18-22, Honkomagome, Bunkyo-ku, Tokyo, 113-8677, Japan.

Primary gastric squamous cell carcinoma (SCC) is a rare histological subtype of gastric cancer. Here, we report the first case of primary gastric verrucous carcinoma (VC), a well-differentiated variant of SCC. Gastroscopy revealed a papillary polypoid lesion at the posterior wall of the upper gastric body and isolated squamous epithelium at the greater curvature of the fornix in a 78-year-old woman. Read More

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http://dx.doi.org/10.1007/s00428-019-02542-8DOI Listing
February 2019

Which Clinicopathologic Factors Affect the Prognosis of Gingival Squamous Cell Carcinoma: A Population Analysis of 4,345 Cases.

J Oral Maxillofac Surg 2019 Jan 15. Epub 2019 Jan 15.

Assistant Professor, Division of Oral and Maxillofacial Pathology, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY. Electronic address:

Purpose: The purpose of this study was to present the characteristics and survival outcomes of primary gingival squamous cell carcinoma (SCC).

Materials And Methods: We performed a retrospective cohort study using data from the Surveillance, Epidemiology, and End Results (SEER) tumor registry. Patients who received a diagnosis of primary gingival SCC were included in the analyses. Read More

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http://dx.doi.org/10.1016/j.joms.2019.01.007DOI Listing
January 2019

Cutaneous Verrucous Carcinoma Superimposed on Chronically Inflamed Ileostomy Site Skin: A Case Report.

Iran J Pathol 2018 17;13(2):285-288. Epub 2018 Jul 17.

Dept. of Surgery, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran.

Verrucous carcinoma (VC) is a rare variant of well differentiated squamous cell carcinoma (SCC) which is usually found in oral cavity mucosa. Cutaneous verrucous carcinoma is a rare entity and in this paper we report a 43 years old man with VCsuperimposed on chronically inflamed skin of ileostomy site. Previously, he was operated to treat rectal adenocarcinoma and has had ileostomy for six months. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339498PMC
July 2018
1 Read

HPV-Related Papillary Lesions of the Oral Mucosa: A Review.

Authors:
Sasha J Betz

Head Neck Pathol 2019 Jan 29. Epub 2019 Jan 29.

Division of Anatomic Pathology, Naval Medical Center San Diego, 34800 Bob Wilson Drive, San Diego, CA, 92134-5000, USA.

Human papillomaviruses (HPVs) are causative of a group of clinically papillary lesions. The HPV-related lesions of the oral cavity include squamous papilloma, condyloma acuminatum, verruca vulgaris, and multifocal epithelial hyperplasia. Benign entities, such as verruciform xanthoma or giant cell fibroma, as well as malignancies, such as papillary squamous cell carcinoma and verrucous carcinoma, may be considered in the clinical and/or histologic differential diagnoses of these lesions. Read More

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http://dx.doi.org/10.1007/s12105-019-01003-7DOI Listing
January 2019
3 Reads

[Clinicopathological Study of the Resected Oral Leukoplakia Cases].

Gan To Kagaku Ryoho 2018 Dec;45(13):1970-1972

Dept. of Oral and Maxillofacial Surgery, National Hospital Organization Hamada Medical Center.

Oral leukoplakia is the most common premalignant or potentially malignant lesion in the oral mucosa. This retrospective study examined 67 lesions from 62 patients with clinical diagnoses of oral leukoplakia who underwent surgical excision in our department from 2015 to 2017. The patients comprised 22 men and 40 women. Read More

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December 2018

Lichenoid Characteristics in Premalignant Verrucous Lesions and Verrucous Carcinoma of the Oral Cavity.

Head Neck Pathol 2019 Jan 22. Epub 2019 Jan 22.

University of Florida, Gainesville, USA.

Verrucous hyperkeratosis (VH), verrucous carcinoma (VC) and the relentless, truly pre-malignant variant proliferative verrucous leukoplakia often exhibit lichenoid histologic features that may create a diagnostic dilemma for pathologists. This study aims to evaluate and categorize the frequency and the histopathologic patterns of lichenoid features seen in these lesions. Following IRB approval, cases of VH and VC from 1994 to 2014 were retrieved from the archives of UF Oral Pathology Biopsy Service. Read More

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http://dx.doi.org/10.1007/s12105-019-01006-4DOI Listing
January 2019

Epidemiological and Histopathological Aspects of Tongue Squamous Cell Carcinomas-Retrospective Study.

Curr Health Sci J 2018 Jul-Sep;44(3):211-224. Epub 2018 Jul 15.

Department of Clinical Pharmacology, University of Medicine and Pharmacy of Craiova, Romania.

Tongue squamous cell carcinoma is one of the most commonly diagnosed intraoral squamous cell carcinomas (25-40%), being considered an aggressive form of squamous cell carcinoma, as it is most commonly associated with lymph node metastases and the survival rate at five years is below 50%. In according with these data, we have proposed in this study to individualize an epidemiological and histopathological profile of the patients with such oral cancers, diagnosed and treated in the Oral and Maxillofacial Surgery Clinic and in the Otolaryngology Surgery Clinic of the Emergency Clinical County Hospital Craiova, between 2015-2017. The cases were histopathologically reassessed according to the latest WHO classification of head and neck tumors, the variables of interest being the age of the patients, the gender, the lesion topography, the histological subtype, the degree of tumor differentiation, the pTNM stage, the resection margin status and the Brandwein-Gensler prognostic score. Read More

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http://dx.doi.org/10.12865/CHSJ.44.03.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311229PMC

Ungual Horn.

Skin Appendage Disord 2018 Nov 22;5(1):56-59. Epub 2018 Jun 22.

Department of Dermatology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA.

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http://dx.doi.org/10.1159/000487964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323382PMC
November 2018

Oral carcinoma cuniculatum, an unacquainted variant of oral squamous cell carcinoma: A systematic review.

Imaging Sci Dent 2018 Dec 20;48(4):233-244. Epub 2018 Dec 20.

Oral and Maxillofacial Radiology Department, Faculty of Dentistry, Cairo University, Egypt.

Purpose: Oral carcinoma cuniculatum is a rare well-differentiated variant of oral squamous cell carcinoma. The purpose was to systematically review its unique features to differentiate it from other variants as verrucous carcinoma, papillary squamous cell carcinoma and well-differentiated squamous cell carcinoma.

Materials And Methods: A systematic review was performed using MEDLINE, Dentistry and Oral Sciences Source and PubMed databases and any existing articles related to the research subject missed in the search strategy to screen ones reporting cases occurring exclusively in the oral cavity in English literature. Read More

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http://dx.doi.org/10.5624/isd.2018.48.4.233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305781PMC
December 2018

Early Onset of Squamous Cell Carcinoma Arising From Tuberculosis Verrucosa Cutis.

J Am Coll Clin Wound Spec 2017 21;9(1-3):35-38. Epub 2018 Jun 21.

Department of Medicine, Hospital Sultan Abdul Halim, 08000 Sungai Petani, Kedah, Malaysia.

A 72-year-old man presented with a chronic scaly verrucous plaque over his right knee for nine months. The lesion was preceded by a well healed scar sustained five years back from a road traffic accident. He was given multiple courses of systemic antibiotic and antifungal medications but to no avail. Read More

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http://dx.doi.org/10.1016/j.jccw.2018.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304292PMC
June 2018
2 Reads

Non-urothelial carcinomas of the bladder.

Histopathology 2019 Jan;74(1):97-111

Department of Pathology, University of California at San Diego, La Jolla, CA, USA.

Non-urothelial carcinomas involving the bladder are uncommon and often diagnostically challenging. These carcinomas may show squamous, adenocarcinomatous or neuroendocrine features, with immunohistochemical stains aiding the diagnosis in only a subset of cases. The clinical history in non-urothelial bladder carcinomas is important, given that the differential diagnosis often includes secondary involvement of the bladder by direct extension or metastasis from carcinomas at other sites. Read More

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http://dx.doi.org/10.1111/his.13719DOI Listing
January 2019
1 Read

Recurrent oral squamous papilloma in a pediatric patient: Case report and review of the literature.

Niger J Clin Pract 2018 Dec;21(12):1674-1677

Department of Oral and Maxillofacial Pathology/Biology, Lagos University Teaching Hospital, Lagos, Nigeria.

Squamous papillomas are common lesions of the oral mucosa. They are benign proliferating lesions often painless, slow growing and with a cauliflower appearance. However, its clinical appearance which sometimes mimics exophytic carcinoma, verrucous carcinoma or condyloma acuminatum raises concern when it occurs in the oral cavity. Read More

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http://dx.doi.org/10.4103/njcp.njcp_407_17DOI Listing
December 2018
1 Read

Single-stage reconstruction of large defect of oral commissure and lips by submental artery island flap.

Natl J Maxillofac Surg 2018 Jul-Dec;9(2):222-224

Department of Gynaecology and Obstetrics, Apollo Institute of Medical Sciences, Hyderabad, Telangana, India.

Large defect of the lip and buccal mucosa created due to wide resection of the cancer is difficult to reconstruct and always a challenge. Such defects are complex as there is loss of outer skin, muscle, soft tissue, and inner mucosal lining. We report the use of submental artery island flap (SAIF) in the reconstruction of a large defect of oral commissure and buccal mucosa in a 70-year-old female with the diagnosis of verrucous carcinoma. Read More

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http://www.njms.in/text.asp?2018/9/2/222/245351
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http://dx.doi.org/10.4103/njms.NJMS_61_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251293PMC
December 2018
8 Reads

Sinonasal inverted papilloma associated with small cell neuroendocrine carcinoma: A case report and literature review of rare malignancies associated with inverted papilloma.

Auris Nasus Larynx 2018 Dec 10. Epub 2018 Dec 10.

Departments of Otorhinolaryngology, Nagoya City University, Japan.

We report a rare case of sinonasal inverted papilloma (IP) associated with small cell neuroendocrine carcinoma (SNEC). To our knowledge, this is the first report to describe SNEC found during the treatment of sinonasal IP. Surgery and five cycles of cisplatin plus etoposide with concurrent intensity modulated radiation therapy were performed. Read More

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http://dx.doi.org/10.1016/j.anl.2018.10.009DOI Listing
December 2018
1 Read

Proliferative verrucous leukoplakia and its tumor markers: Systematic review and meta-analysis.

Head Neck 2018 Dec 11. Epub 2018 Dec 11.

Faculty of Medicine, Department of Oral Pathology, Institute of Dentistry, University of Turku, Turku, Finland.

Background: The aim was to update information on oral proliferative verrucous leukoplakia (PVL), a disease of verrucous-like lesions with high risk of malignancy, and its biomarkers.

Methods: A systematic search of literature on PVL and its biomarkers showed 22 biomarkers that were investigated in 19 papers. A meta-analysis was possible for human papillomavirus (HPV), aneuploidy, Ki-67, and p53. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/hed.25569
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http://dx.doi.org/10.1002/hed.25569DOI Listing
December 2018
23 Reads

Epidemiology of Subcutaneous Mycoses in Northeast India: A Retrospective Study.

Indian J Dermatol 2018 Nov-Dec;63(6):496-501

Department of Dermatology and STD, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India.

Background: Subcutaneous mycoses, although rare, are frequently reported from northeast India. Their spectrum varies with geographic region.

Materials And Methods: We evaluated clinical records and histopathological features of subcutaneous mycoses cases seen during April 2013 to March 2017. Read More

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http://dx.doi.org/10.4103/ijd.IJD_16_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233045PMC
December 2018
4 Reads

Anogenital Verrucous Carcinoma-A case report.

Int J Surg Case Rep 2019 27;54:7-9. Epub 2018 Nov 27.

Department of Plastic Surgery and Breast Surgery, Zealand University Hospital, Roskilde, Denmark.

Introduction: Verrucous carcinoma is an uncommon variant of low-grade squamous cell malignancy with a low malignant potential but a high risk of recurrence.

Presentation Of Case: We report a case of a Human Papilloma Virus negative local verrucous carcinoma in the perianal area of a 45-year old otherwise healthy female. The tumor presented clinically as a persistent genital wart not responding to usual dermatologic local therapy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612183052
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http://dx.doi.org/10.1016/j.ijscr.2018.11.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280022PMC
November 2018
9 Reads

Premalignant and Malignant Mucosal lesions: Clinical and Pathological Findings Part II. Premalignant and malignant mucosal lesions.

J Am Acad Dermatol 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology, Boston University School of Medicine, Boston, MA. Electronic address:

Part 2 of this 2-part continuing medical education series discusses the clinical and histopathologic features of common premalignant and malignant lesions of the oral cavity. It is imperative for dermatologists to be able to recognize suspicious lesions, determine biopsy need, counsel, and refer patients presenting with premalignant or malignant conditions appropriately. Given the higher rates of mortality and morbidity of oral mucosal malignancies due to late diagnosis, appropriate treatment with multidisciplinary care in a timely manner is essential to these neoplasms. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183288
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http://dx.doi.org/10.1016/j.jaad.2018.09.060DOI Listing
November 2018
7 Reads

Human papillomavirus infection is not involved in esophageal verrucous carcinoma.

Hum Pathol 2018 Nov 10. Epub 2018 Nov 10.

Department of Medicine, Surgical Pathology Unit, University of Padua, Padua, Italy.

Verrucous carcinoma of the esophagus (VCE) is a rare variant of squamous cell cancer, with a puzzling clinical, etiological, and molecular profile. The etiological involvement of human papillomavirus (HPV) in the cancer's natural history is controversial. This study considers nine cases of VCE, focusing on patients' clinical history before surgery, histological phenotype, immunophenotype (EGFR, E-cadherin, cyclin D1, p16, and p53 expression), HPV infection, and TP53 gene mutational status (exons 5-8). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00468177183042
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http://dx.doi.org/10.1016/j.humpath.2018.10.024DOI Listing
November 2018
10 Reads
2.770 Impact Factor

A Rare Variant of Penile Squamous Cell Carcinoma in a Man with Paraplegia.

Cureus 2018 Sep 3;10(9):e3244. Epub 2018 Sep 3.

Dermatology, University of Texas Mcgovern Medical School at Houston, Houston, USA.

Verrucous carcinoma (VC) is a rare variant of squamous cell carcinoma (SCC). It is described as a low grade, slow growing, locally infiltrative neoplasm that accounts for 3%-8% of penile SCCs. Here we report a case of destructive VC of the glans penis in a paraplegic man resulting in a hypospadias from the tip of the glans to the corona. Read More

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https://www.cureus.com/articles/13215-a-rare-variant-of-peni
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http://dx.doi.org/10.7759/cureus.3244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217864PMC
September 2018
9 Reads

Verrucous carcinoma arising from a previous cystic lesion: a case report.

Maxillofac Plast Reconstr Surg 2018 Dec 25;40(1):31. Epub 2018 Oct 25.

2Department of Oral and Maxillofacial Surgery, School of Dentistry, Chonbuk National University, 567 Baekje-daero, Deokjin-gu, Jeonju-si, Jeollabuk-do 54896 South Korea.

Background: Verrucous carcinoma (VC) accounts for 1-10% of cases of squamous cell carcinoma (SCC) in the oral cavity, and 75% of VC occur in the oral cavity. Only 3% of primary intraosseous squamous cell carcinomas (PIOSCC), which means SCC occurring primarily in the bone, are VC. Verrucous carcinoma arising from odontogenic cysts (OC) is very rare, with only seven cases reported to date. Read More

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https://jkamprs.springeropen.com/articles/10.1186/s40902-018
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http://dx.doi.org/10.1186/s40902-018-0169-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200831PMC
December 2018
8 Reads

[Epidermodysplasia verruciformis: about a case].

Pan Afr Med J 2018 29;30:78. Epub 2018 May 29.

Hôpital Civil Tétouan, Tétouan, Maroc.

Epidermodysplasia verruciformis, also known as Lewandowsky-Lutz syndrome or tree man disease is a rare genetic skin disorder. It is characterized by abnormal susceptibility of the skin coating to human papillomaviruses (HPVs). It commonly affects people between the ages of 4 and 8, most often before the age of 20 years but it may exceptionally occur later. Read More

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http://dx.doi.org/10.11604/pamj.2018.30.78.16058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191268PMC
October 2018
4 Reads

Treatment of verrucous carcinoma in penis with topical aminolevulinic acid photodynamic therapy: An effective and safe treatment method.

Photodiagnosis Photodyn Ther 2018 Dec 8;24:232-236. Epub 2018 Sep 8.

Department of Plastic & Cosmetic Surgery, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, PR China. Electronic address:

Background: Verrucous carcinoma of the penis is a rare disease characterized by verrucous lesions. The traditional treatment methods for verrucous carcinoma result in loss of sexual function are not satisfactory. The purpose of this study was to evaluate the safety and effect of topical aminolevulinic acid photodynamic therapy in the treatment of verrucous carcinoma in penis. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2018.08.015DOI Listing
December 2018
11 Reads

Verruciform and Condyloma-like Squamous Proliferations in the Anogenital Region.

Authors:
May P Chan

Arch Pathol Lab Med 2018 Sep 11. Epub 2018 Sep 11.

From the Department of Pathology, University of Michigan Health System, Ann Arbor.

Context: - Histologic distinction between condyloma acuminatum and various benign and malignant condyloma-like lesions in the anogenital area poses a common diagnostic challenge to pathologists across subspecialties.

Objective: - To review the overlapping and distinguishing features of condyloma acuminatum and its mimics, and to clarify confusing terminology and diagnostic criteria for problematic entities.

Data Sources: - A review of the literature on condyloma acuminatum (ordinary and giant types), verrucous carcinoma, warty/warty-basaloid high-grade squamous intraepithelial lesion and squamous cell carcinoma, papillary squamous cell carcinoma, bowenoid papulosis, verruca vulgaris, epidermolytic acanthoma, and verruciform xanthoma was performed. Read More

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http://dx.doi.org/10.5858/arpa.2018-0039-RADOI Listing
September 2018
7 Reads

Correlation of serum lactate dehydrogenase and alkaline phosphatase in different histological grades of head and neck squamous cell carcinoma and premalignant lesions.

J Cancer Res Ther 2018 Jul-Sep;14(5):934-940

Department of Radiation Oncology, Silchar Medical College, Silchar, Assam, India.

Context: Head neck cancer (HNCA) in North-East India accounts for 54.48% cancers at all sites, one of the highest in the country. Increased serum lactate dehydrogenase (LDH) activity is considered as a marker of cellular necrosis while serum alkaline phosphatase (ALP) is recognized as an important marker of induction of tumor cell differentiation. Read More

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http://dx.doi.org/10.4103/0973-1482.172718DOI Listing
November 2018
9 Reads

Verrucous Carcinoma Arising in Association With Giant Condyloma.

Int J Surg Pathol 2018 Sep 5:1066896918796647. Epub 2018 Sep 5.

1 Brown University, Providence, RI, USA.

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http://dx.doi.org/10.1177/1066896918796647DOI Listing
September 2018
2 Reads

Successful treatment of giant condyloma in a pediatric heart transplant recipient with topical cidofovir.

Transpl Infect Dis 2018 Dec 28;20(6):e12989. Epub 2018 Sep 28.

Department of Pediatrics, Division of Infectious Diseases, University of Texas Southwestern Medical Center, Dallas, Texas.

We report a case of giant condyloma that developed in a pediatric heart transplant recipient. This infection progressed for several months despite reduction in immunosuppression, topical treatment, and oral cimetidine therapy. Complete resolution was observed following 7 months of topical cidofovir, without evidence of systemic toxicity or rejection. Read More

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http://doi.wiley.com/10.1111/tid.12989
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http://dx.doi.org/10.1111/tid.12989DOI Listing
December 2018
25 Reads

Human papilloma virus and genitourinary cancers: a narrative review.

Minerva Urol Nefrol 2018 Dec 29;70(6):579-587. Epub 2018 Aug 29.

Unit of Urology, University of Pisa, Pisa, Italy -

Introduction: Human papilloma virus (HPV) is the most common sexually transmitted pathogen and its potential role in the genesis of several diseases such as cervical, head and neck, anal and penile cancers, is now largely recognized. Aim of this review article was to evaluate and summarize the state of the art of HPV-related urogenital cancers, focusing on the potentially innovative methods for the diagnosis of infection that should be used to improve viral causative detection and prevent its diffusion through sexual intercourses.

Evidence Acquisition: The initial search was carried out by using the Medline and the Google Scholar computerized databases through the selected key-words to identify the more recent literature on HPV epidemiology and its relationship with the main relevant urinary tract cancers. Read More

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http://dx.doi.org/10.23736/S0393-2249.18.03141-7DOI Listing
December 2018
22 Reads

[Clinicopathological features and management of penile verrucous carcinoma].

Zhonghua Nan Ke Xue 2018 Janurary;24(1):62-66

Department of Urology, Henan Provincial People's Hospital / People's Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China.

Objective: To explore the clinicopathological characteristics, diagnosis and treatment of penile verrucous carcinoma (VC).

Methods: We retrospectively analyzed the clinical data about 18 penile VC patients at the mean age of 52 (35-66) years. The tumors were cauliflower-like, measuring 2. Read More

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November 2018
17 Reads

The Role of Human Papillomaviruses and Polyomaviruses in BRAF-Inhibitor Induced Cutaneous Squamous Cell Carcinoma and Benign Squamoproliferative Lesions.

Front Microbiol 2018 14;9:1806. Epub 2018 Aug 14.

Centre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.

Human papillomavirus (HPV) has long been proposed as a cofactor in the pathogenesis of cutaneous squamous cell carcinoma (cSCC). More recently, the striking clinico-pathological features of cSCCs that complicate treatment of metastatic melanoma with inhibitors targeting BRAF mutations (BRAFi) has prompted speculation concerning a pathogenic role for oncogenic viruses. Here, we investigate HPV and human polyomaviruses (HPyV) and correlate with clinical, histologic, and genetic features in BRAFi-associated cSCC. Read More

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http://dx.doi.org/10.3389/fmicb.2018.01806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102365PMC
August 2018
16 Reads

Carcinoma cuniculatum in the tongue of a patient with oral lichen planus: Unusual presentation.

Indian J Dent Res 2018 Jul-Aug;29(4):525-528

Department of Oral Pathology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.

Carcinoma cuniculatum (CC) is a rare variant of squamous cell carcinoma (SCC). Only 27 cases have been published in English. A 50-year-old male, who presented a white nodule with erythematous areas, localized in the lateral border of the tongue with 2 months of duration. Read More

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http://dx.doi.org/10.4103/ijdr.IJDR_185_16DOI Listing
February 2019
15 Reads

First case report of malignant peritoneal mesothelioma and oral verrucous carcinoma in a patient with a germline PTEN mutation: a combination of extremely rare diseases with probable further implications.

BMC Med Genet 2018 Aug 15;19(1):144. Epub 2018 Aug 15.

Institute of Medical Genetics and Applied Genomics, University of Tübingen, Calwerstr. 7, 72076, Tübingen, Germany.

Background: The PTEN-hamartoma-tumor-syndrome (PHTS) is caused by germline mutations in Phosphatase and Tensin homolog (PTEN) and predisposes to the development of several typical malignancies. Whereas PTEN mutations have been implicated in the occurrence of malignant mesotheliomas, the genetic landscape of verrucous carcinomas (VC) is largely uncharted. Both VC and malignant peritoneal mesotheliomas (MPM) are exceedingly rare and a potential link between these malignancies and PHTS has never been reported. Read More

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http://dx.doi.org/10.1186/s12881-018-0651-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6094911PMC
August 2018
6 Reads

Orthokeratinized odontogenic cysts: a Spanish tertiary care centre study based on HPV DNA detection.

Head Face Med 2018 Jul 13;14(1):10. Epub 2018 Jul 13.

Department of Pathology, Faculty of Medicine and Dentistry, La Fe University Hospital, University of Valencia, Torre A, 2° planta, Avda. Fernando Abril Martorell 106, 46026, Valencia, Comunidad Valenciana, Spain.

Background: The role of human papillomavirus (HPV) in orthokeratinized odontogenic cysts (OOCs) has rarely been studied. The objective is to describe the clinicopathological findings in a series of OOCs from a Spanish population that were investigated in relation to the possible presence of HPV.

Methods: A clinicopathological retrospective analysis followed by a molecular analysis of 28 high- and low-risk HPV genotypes was performed in OOC samples of patients seen during the last 15-years in a Spanish tertiary care center. Read More

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http://dx.doi.org/10.1186/s13005-018-0167-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043989PMC
July 2018
5 Reads

Squamous cell carcinoma arising in hypertrophic lichen planus.

BMJ Case Rep 2018 Jul 11;2018. Epub 2018 Jul 11.

Department of Dermatology, LUMC, Leiden, The Netherlands.

Hypertrophic lichen planus (HLP) is a chronic T-cell-mediated inflammatory disease characterised by pruritic hypertrophic or verrucous plaques on the lower limbs. We report a case of an 87-year-old woman with a 12-year history of HLP on both lower legs presenting with malignant transformation of one lesion into a squamous cell carcinoma (SCC). Malignancy developing in cutaneous lichen planus is rare, with less than 50 cases reported in the literature. Read More

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http://dx.doi.org/10.1136/bcr-2017-224044DOI Listing
July 2018
25 Reads

Recalcitrant lip verrucous carcinoma successfully treated with acitretin after carbon dioxide laser ablation.

JAAD Case Rep 2018 Jul 12;4(6):576-578. Epub 2018 Jun 12.

Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

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https://linkinghub.elsevier.com/retrieve/pii/S23525126183003
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http://dx.doi.org/10.1016/j.jdcr.2018.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038266PMC
July 2018
11 Reads

Unusual Papillary Squamous Cell Carcinoma of the Tip of Tongue Presenting in a Patient Status Post Heart Transplant.

Anticancer Res 2018 Jul;38(7):4203-4206

Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, U.S.A.

Oral papillary squamous cell carcinoma (PSCC) is an unusual variant of squamous cell carcinoma with a better prognosis. The most common location of PSCC in the oral cavity is the gingiva and buccal mucosa, and it is exceedingly rare in the tongue. Herein, we present a case of PSCC in an 85-year-old male with a history of heart transplant and long-term use of immunosuppression medication. Read More

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http://dx.doi.org/10.21873/anticanres.12715DOI Listing
July 2018
14 Reads

[Pigmented extramammary Paget's disease accompanied with condyloma acuminatum: a case report].

Beijing Da Xue Xue Bao Yi Xue Ban 2018 Jun;50(3):572-575

Department of Dermatology, Peking University People's Hospital, Beijing 100044, China.

Pigmented extramammary Paget's disease (PEMPD) is an uncommon intraepithelial adenocarcinoma and a rare variant of Paget's disease, characterized as a superficial pigmented scaly macule clinically and an increased number of melanocytes scattered between the Paget's cells histologically. So it may be confused clinically and histologically with melanocytic tumors, dermatitis and other dermatoses. Different therapeutic attitudes are required in this case of adenocarcinoma in situ as opposed to melanoma and dermatitis. Read More

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June 2018
11 Reads

Systemic therapy in non-conventional cancers of the larynx.

Oral Oncol 2018 Jul 26;82:61-68. Epub 2018 May 26.

Department of Hematology and Medical Oncology, Emory University, 1365 Clifton Road Building C, Atlanta, GA 30322, United States; Winship Cancer Institute, Emory University, 1365 Clifton Road Building C, Atlanta, GA 30322, United States. Electronic address:

Laryngeal cancer (LC) remains a challenging disease to treat. The majority of LCs diagnosed worldwide are squamous cell carcinomas (SCC), and current treatment guidelines are designed to address conventional laryngeal SCC. However, several histologically rare tumor types can originate in the larynx. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2018.05.005DOI Listing
July 2018
21 Reads

Malignant Transformation of a Canine Papillomavirus Type 1-Induced Persistent Oral Papilloma in a 3-Year-Old Dog.

J Vet Dent 2018 Jun;35(2):79-95

2 Veterinary Pathology, Institute of Veterinary, Animal & Biomedical Sciences, Massey University, New Zealand.

This case report describes a rare case of a persistent canine papillomavirus type 1 (CPV-1)-induced oral papilloma that underwent malignant transformation into an oral squamous cell carcinoma (OSCC) in a 3-year-old Labrador retriever cross. Initially, the patient had multiple and multifocal verrucous lesions populating the oral cavity exclusively. The papillomas persisted despite multiple surgical ablations, azithromycin, interferon α-2b, alternative medicines, and off-label drug use of an immunostimulant. Read More

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http://dx.doi.org/10.1177/0898756418774575DOI Listing
June 2018
1 Read

Corrigendum to "Mistaken Diabetic Ulcers: A Case of Bilateral Foot Verrucous Carcinoma".

Case Rep Dermatol Med 2018 15;2018:6405129. Epub 2018 Apr 15.

Division of Plastic Surgery, Department of Surgery, University of Calgary, Calgary, AB, Canada.

[This corrects the article DOI: 10.1155/2018/4192657.]. Read More

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http://dx.doi.org/10.1155/2018/6405129DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925013PMC
April 2018
2 Reads

Mistaken Diabetic Ulcers: A Case of Bilateral Foot Verrucous Carcinoma.

Case Rep Dermatol Med 2018 23;2018:4192657. Epub 2018 Jan 23.

Department of Obstetrics and Gynecology, University of Calgary, Calgary, AB, Canada.

Verrucous carcinoma (VC) is a rare, low-grade, and well-differentiated variant of squamous cell carcinoma. These tumors are slow-growing and exophytic and have a negligible incidence of metastasis. Treatment is complete surgical resection, ideally by Mohs micrographic surgery, to ensure adequate clear margins. Read More

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http://dx.doi.org/10.1155/2018/4192657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896404PMC
January 2018
1 Read

Verrucous carcinoma of the esophagus-remains a diagnostic enigma.

Am J Gastroenterol 2018 Jun;113(6):919-921

Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

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http://dx.doi.org/10.1038/s41395-018-0065-0DOI Listing
June 2018
3 Reads

Two Cases of Chronic Candidiasis in Keratitis-Ichthyosis-Deafness Syndrome.

Am J Dermatopathol 2018 Oct;40(10):e138-e141

Dermatology Program, Harvard Medical School, Boston Children's Hospital, Boston, MA.

Keratitis-ichthyosis-deafness (KID) syndrome is a rare genodermatosis that typically results from mutations of the GJB2 gene or, less commonly, the GJB6 gene. Patients with KID syndrome are at higher risk of malignancy and infections. Here, we present 2 patients with KID syndrome who developed verrucous plaques. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001178DOI Listing
October 2018

A Case of Oral Florid Papillomatosis (Verrucous Carcinoma) With Lack of Evidence for Human Papillomavirus Involvement.

Am J Dermatopathol 2018 Apr 24. Epub 2018 Apr 24.

Department of Dermatology, Rambam Health Care Campus and The Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel.

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http://dx.doi.org/10.1097/DAD.0000000000001168DOI Listing
April 2018
3 Reads

Dermatologic toxicity from novel therapy using antimicrobial peptide LL-37 in melanoma: A detailed examination of the clinicopathologic features.

J Cutan Pathol 2018 Jul 16;45(7):539-544. Epub 2018 May 16.

Department of Pathology, The University of Texas, MD Anderson Cancer Center, Houston, Texas.

LL-37 is a naturally occurring 37-amino-acid peptide that is part of the innate immune system in human skin. Preclinical studies have showed that intra-tumoral injections of LL-37 stimulate the innate immune system by activation of plasmacytoid dendritic cells, which mediate tumor destruction. LL-37 intra-tumoral injections have been utilized in a phase 1 clinical trial for melanoma patients with cutaneous metastases. Read More

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http://dx.doi.org/10.1111/cup.13262DOI Listing
July 2018
13 Reads
1.560 Impact Factor

Potentially malignant disorders revisited-The lichenoid lesion/proliferative verrucous leukoplakia conundrum.

J Oral Pathol Med 2018 Jul 29;47(6):557-565. Epub 2018 Apr 29.

Newcastle University Medicine Malaysia, Iskandar Puteri, Malaysia.

Background: Clinically identifiable potentially malignant disorders (PMD) precede oral squamous cell carcinoma development. Oral lichenoid lesions (OLL) and proliferative verrucous leukoplakia (PVL) are specific precursor lesions believed to exhibit both treatment resistance and a high risk of malignant transformation (MT).

Methods: A retrospective review of 590 PMD patients treated in Northern England by CO laser surgery between 1996 and 2014 was carried out. Read More

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http://doi.wiley.com/10.1111/jop.12716
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http://dx.doi.org/10.1111/jop.12716DOI Listing
July 2018
17 Reads

MCM-2 expression differentiates potentially malignant verrucous lesions from oral carcinomas.

Ann Diagn Pathol 2018 Jun 13;34:72-76. Epub 2018 Mar 13.

Department of Oral and Maxillofacial Pathology, SDM College of Dental Sciences and Hospital, Dharwad 580 009, Karnataka, India.

Background: Mcm-2 is a biomarker belonging to Mcm family of proteins which has rarely been used in oral potentially malignant and malignant lesions of the verrucous type. The objective of this study is to assess the expression of Mcm-2 in Normal Oral Mucosa (NM), Verrucous Hyperplasia (VH), Verrucous Carcinoma (VC) and Oral Squamous Cell Carcinoma (OSCC) and compare it with the clinicopathological characteristics.

Methodology: A total of 70 formalin fixed paraffin embedded tissue samples (10 cases of Normal Mucosa NM- Group A, 10 cases of Verrucous Hyperplasia- VH without Dysplasia- Group B, 10 cases of Verrucous Hyperplasia- VH with Dysplasia- Group C, 20 cases of Verrucous Carcinoma VC-Group D, 20 cases of Oral Squamous Cell Carcinoma OSCC- Group E) were subjected to immunohistochemistry with Mcm-2 antibody. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.03.001DOI Listing
June 2018
4 Reads

BCL-X expression in oral cancer: Comparison between oral squamous cell carcinoma and verrucous carcinoma.

Indian J Dent Res 2018 Mar-Apr;29(2):196-200

Department of Oral and Maxillofacial Surgery, Yenepoya Dental College, Yenepoya University, Mangalore, Karnataka, India.

Background: Verrucous carcinoma (VC) should be considered a distinct clinicopathologic entity different from the more common oral squamous cell carcinoma (OSCC) because of its unique biological behavior. Best way to understand the behavior of these carcinomas is to study them by means of molecular methods, especially in tumor progression tests and Bcl-X is an important antiapoptotic member of the Bcl-2 family and is one of the newest and most useful markers to determine the aggressiveness of many carcinomas. The relationship between this Bcl-X protein and carcinomatous behavior toward it is not studied extensively, which we attempted to evaluate using immunohistochemical analysis in selected carcinomas of the head and neck region. Read More

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http://dx.doi.org/10.4103/ijdr.IJDR_711_16DOI Listing
November 2018
30 Reads

Genitogluteal porokeratosis in an HIV-positive man: a case report and review of the literature on genital porokeratosis.

Dermatol Online J 2018 Mar 15;24(3). Epub 2018 Mar 15.

Department of Dermatology, University of California San Diego, La Jolla, California.

Genitogluteal porokeratosis is a disorder of keratinization that may present in men in their fourth decade of life. We describe a 52-year-old human immunodeficiency virus (HIV)-positive man with history of anal squamous cell carcinoma who developed verrucous lesions on the buttocks and genitals. The buttock lesions presented shortly after radiotherapy for anal carcinoma a decade prior, whereas the genital lesions presented three months prior in areas treated with injectable medication for erectile dysfunction. Read More

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March 2018
7 Reads