Int J Gynecol Pathol 2020 Dec 14. Epub 2020 Dec 14.
Department of Anatomical Pathology, Vancouver General Hospital and University of British Columbia (J.P., B.T.-C., E.T., N.A., J.H., B.G., L.H.) Department of Molecular Oncology, British Columbia Cancer Research Center (D.H.), Vancouver, British Columbia, Canada.
Recurrent vulvar squamous cell carcinomas (SCCs) are a poorly understood and aggressive group of treatment-resistant neoplasms. Currently, it remains unclear whether these are in fact recurrences of the same primary tumor, or the development of entirely new tumors. Here, to address this question, we examined the mutational profile of a series of patients with recurrent or multifocal non-human papilloma virus (HPV)-associated vulvar SCC. Read More