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    1 OF 38

    Keratoacanthoma en plaque/nodule: A brief report of the clinicopathological features of five cases.
    J Dermatol 2017 Mar 23. Epub 2017 Mar 23.
    Division of Dermatology, Nakao Clinic, Saga, Japan.
    Keratoacanthoma (KA) is characterized by exoendophytic growth with a central keratin-filled crater, representing the crateriform architecture. We herein report five rare cases of KA without a central keratin-filled crater. These KA cases histopathologically showed that one or a few infundibular structures/isthmic lobules had their own open keratotic pores on the surface without a common merged keratotic plug/horn, clinically representing verrucous (keratotic) plaque/nodule, namely, "KA en plaque/nodule". Read More

    Squamous cell carcinoma arising in a multiple verrucous epidermal nevus.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):166-168
    Universidade Federal de São Paulo (UNIFESP) - São Paulo (SP), Brazil.
    Verrucous epidermal nevi are hamartomatous lesions of the epidermis that, unlike other epidermal nevi (such as sebaceous nevus or nevus comedonicus), are rarely associated with malignant neoplasms. The majority of squamous cell carcinoma develop in linear or multiple epidermal nevus and rarely in solitary epidermal nevus. In general, the prognosis is favorable. Read More

    Oral Carcinoma Cuniculatum: A New Entity in the Clinicopathological Spectrum of Oral Squamous Cell Carcinoma.
    J Clin Diagn Res 2017 Jan 1;11(1):ZD37-ZD39. Epub 2017 Jan 1.
    Professor, Department of Oral Pathology and Microbiology, KLE VK Institute of Dental Sciences , Belgaum, Karnataka, India .
    Carcinoma cuniculatum is principally recognized as a variant of carcinoma involving foot. The World Health Organization (WHO) recognizes Oral Carcinoma Cuniculatum (OCC) as a distinct and rare clinicopathological variant of Oral Squamous Cell Carcinoma (OSCC). OCC is confused clinically and histologically with Verrucous Carcinoma (VC) and is often misdiagnosed as either VC or OSCC. Read More

    Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: What is New in the 2017 WHO Blue Book for Tumours of the Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
    Head Neck Pathol 2017 Mar 28;11(1):23-32. Epub 2017 Feb 28.
    Institute of Pathology, Faculty of Medicine, University of Ljubljana, Korytkova 2, 1000, Ljubljana, Slovenia.
    Chapter 3 "Tumours of the hypopharynx, larynx, trachea, and parapharyngeal space" of the World Health Organization (WHO) Blue Book 2017 "Classification of Head and Neck Tumours" shows a shortened list of entities, especially due to reducing the number of benign and malignant soft tissue tumours, malignant melanoma and some others, which are transferred to more frequently affected regions of the head and neck. The basic concept of the new edition is to assimilate all advances concerning the discussed tumours in a shorter framework, appropriate for daily work. The main emphasis is on the most frequent lesions and tumors originating from the covering squamous epithelium. Read More

    Update from the 4th Edition of the World Health Organization of Head and Neck Tumours: Tumours of the Oral Cavity and Mobile Tongue.
    Head Neck Pathol 2017 Mar 28;11(1):33-40. Epub 2017 Feb 28.
    Emory University School of Medicine, Atlanta Oral Pathology, 2701 N. Decatur Road, Decatur, GA, 30033, USA.
    There have been several additions and deletions in Chapter 4 on Tumours of the oral cavity and mobile tongue in the 2017 fourth edition of the World Health Organization Classification of Tumours of the Head and Neck. This chapter excludes the oropharynx, which now is a stand-alone chapter acknowledging the uniqueness of the oropharynx from the oral cavity. New entries in Chapter 4 include rhabdomyoma, haemangioma, schwannoma, neurofibroma and myofibroblastic sarcoma in the section titled Soft tissue and neural tumours. Read More

    Proliferative verrucous leukoplakia: diagnosis, management and current advances.
    Braz J Otorhinolaryngol 2017 Jan 24. Epub 2017 Jan 24.
    Federal University of Santa Catarina, Department of Pathology, Florianopolis, SC, Brazil. Electronic address:
    Introduction: Proliferative verrucous leukoplakia is a multifocal and progressive lesion of the oral mucosa, with unknown etiology, and commonly resistant to all therapy attempts with frequent recurrences. It is characterized by a high rate of oral squamous cell carcinoma and verrucou carcinoma transformations.

    Objective: To analyze the studies about Proliferative verrucous leukoplakia and develop a concise update. Read More

    Re-evaluation of epidermodysplasia verruciformis: Reconciling more than 90 years of debate.
    J Am Acad Dermatol 2017 Feb 10. Epub 2017 Feb 10.
    Department of Dermatology, Hadassah-Hebrew University Medical Center, Jerusalem. Electronic address:
    Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by abnormal susceptibility to cutaneous human beta-papillomavirus infections causing persistent flat warts or pityriasis versicolor-like lesions. This generalized verrucous skin disorder resembles generalized verrucosis, but these 2 conditions are distinguished by differences in clinical manifestation and the human papillomavirus types involved. A breakthrough in our understanding of EV was the discovery that homozygous inactivating mutations in TMC6 (EVER1) and TMC8 (EVER2) determine susceptibility to this disorder; however, they have not solved all EV cases fully. Read More

    Warty Carcinoma Penis: An Uncommon Variant.
    Case Rep Pathol 2017 5;2017:2937592. Epub 2017 Jan 5.
    Department of Pathology, Manipal College of Medical Sciences, Pokhara, Nepal.
    Penile carcinoma frequency varies widely in different parts of the world and comprises 1-10% of all the malignancies in males. Majority of the cases of penile carcinoma are squamous cell carcinoma of penis comprising 60% to 70% of all cases. Warty carcinoma of penis is an unusual neoplasm and a variant of penile squamous cell carcinoma comprising 5%-10% of all the variants. Read More

    Laryngeal Dysplasia, Squamous Cell Carcinoma, and Variants.
    Surg Pathol Clin 2017 Mar;10(1):15-33
    Department of Pathology, Southern California Permanente Medical Group, Woodland Hills Medical Center, 5601 De Soto Avenue, Woodland Hills, CA 91367, USA. Electronic address:
    Squamous cell carcinoma (SCC) is a malignant epithelial tumor showing evidence of squamous differentiation. It is the most common malignancy of the larynx, with several variants (verrucous, exophytic or papillary, spindle-cell, basaloid, acantholytic, adenosquamous) recognized, with well-established precursor lesions. Dysplasia is now separated into only low-grade and high-grade categories. Read More

    Adjuvant radiotherapy is not supported in patients with verrucous carcinoma of the oral cavity.
    Laryngoscope 2017 Feb 1. Epub 2017 Feb 1.
    Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, U.S.A.
    Objective: To analyze the impact of adjuvant radiation therapy (RT) on overall survival (OS) and disease-specific survival (DSS) in patients with verrucous carcinoma (VC) as compared to squamous cell carcinoma (SCC) of the oral cavity.

    Study Design: Cross-sectional population analysis.

    Methods: Cases of nonmetastatic VC/SCC of the oral cavity were extracted from the Surveillance, Epidemiology, and End Results (SEER) database (1988-2013). Read More

    [Buschke-Lowenstein tumors].
    Hautarzt 2017 Mar;68(3):199-203
    Hautklinik, Universitätsklinikum der RWTH-Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland.
    Background: A giant condyloma acuminatum which shows destructive growth but lacking invasion is designated as a Buschke-Lowenstein tumor (BLT).

    Objectives: Classification of the BLT and therapeutic guidelines are provided.

    Materials And Methods: A MEDLINE literature search from 2006-2016 was performed. Read More

    Verruciform xanthoma of the penis: A rare benign lesion that simulates carcinoma.
    Arch Ital Urol Androl 2016 Dec 30;88(4):284-285. Epub 2016 Dec 30.
    Department of Urology, IRCCS San Martino, University of Genova.
    Verruciform xanthoma is a rare and benign condition predominantly affecting the oral cavity, but also skin and female anogenital mucosa. It can be flat, papular-warty or crateriform-cystic. Furthermore it can simulate HPV viral lesion such as condyloma and malignant neoplasia such as verrucous squamous cell carcinoma. Read More

    A clitoral verrucous carcinoma in an area of lichen planus has aggressive features.
    World J Surg Oncol 2017 Jan 6;15(1). Epub 2017 Jan 6.
    Department of Obstetrics and Gynecology, Multidisciplinary Breast Clinic, Gynecological Oncology Unit, Antwerp University Hospital - University of Antwerp, Wilrijkstraat 10, Edegem, 2650, Belgium.
    Background: Verrucous carcinoma of the vulva is extremely rare. It is a slow growing, low malignant variant of a squamous cell carcinoma with a cauliflower appearance. Women with lichen planus have an increased risk of developing vulval cancer. Read More

    Squamous cell carcinoma of the upper aerodigestive tract: dysplasia and select variants.
    Mod Pathol 2017 Jan;30(s1):S112-S118
    Department of Pathology, Moffitt Cancer Center, Tampa, FL, USA.
    Upper aerodigestive tract (UADT) mucosal premalignant lesions include non-keratinizing and keratinizing intraepithelial dysplasia. The keratinizing type of intraepithelial dysplasia represents the majority of UADT dysplasias. Historically, grading of UADT dysplasias has followed a three tier system to include mild, moderate and severe dysplasia. Read More

    An Unusual Presentation of Verrucous Carcinoma of the Foot with Bone Invasion.
    J Am Podiatr Med Assoc 2016 Nov;106(6):427-429
    Verrucous carcinoma of the foot is a rare malignancy, and proper diagnosis can be delayed. Furthermore, misdiagnosis often results in delayed appropriate treatment. Herein, we present an unusual case of verrucous carcinoma of the fifth toe with bone invasion in a 63-year-old woman that was mistaken for a plantar wart for 3 years. Read More

    Anal verrucous carcinoma is not related to infection with human papillomaviruses and should be distinguished from giant condyloma (Buschke-Löwenstein tumour).
    Histopathology 2016 Dec 24. Epub 2016 Dec 24.
    Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
    Aims: Verrucous carcinoma (VC) is a variant of well-differentiated squamous cell carcinoma and in the anal region is regarded as synonymous with giant condyloma (Buschke-Löwenstein tumour) (BLT). Aetiology, diagnostic criteria and clinical behaviour of both lesions are controversial. Recent studies suggest that VC at other sites is not associated with human papillomaviruses (HPV). Read More

    A Case of Squamous Cell Carcinoma in the External Auditory Canal Previously Treated for Verrucous Carcinoma.
    J Audiol Otol 2016 Dec 30;20(3):183-186. Epub 2016 Nov 30.
    Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
    Carcinoma in the external auditory canal (EAC) is a rare malignancy with an annual incidence of one per one million people, accounting for less than 0.2% of all head and neck cancers. The most common histopathological type of EAC cancer is squamous cell carcinoma. Read More

    Diagnostic Biomarkers in Oral Verrucous Carcinoma: A Systematic Review.
    Pathol Oncol Res 2017 Jan 6;23(1):19-32. Epub 2016 Dec 6.
    Students' Research Office, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Oral verrucous carcinoma (OVC), a low-grade variant of oral squamous cell carcinoma (OSCC), is most frequently seen in the oral cavity. No clear etiology has been found for this lesion, but human papilloma virus, chewing betel nuts, and ultraviolet radiation are suggested as probable causes. Differential diagnosis of OVC is challenging for oral pathologists. Read More

    Successful improvement of Buschke-Löwenstein tumour in an HIV-infected patient with antiretroviral therapy alone.
    BMJ Case Rep 2016 Nov 21;2016. Epub 2016 Nov 21.
    Hopitaux Universitaires Henri Mondor, Creteil, France.
    Buschke-Löwenstein tumour (BLT), also defined as giant condyloma acuminatum, is a rare exophytic tumour affecting the anogenital and perianal regions associated with human papillomavirus (HPV) infections, with a potential of malignant transformation and which is at a greater risk in T-cell mediated immunodeficient patients. Different therapeutic options, alone or in combination, have been reported for the treatment of BLT including local therapy but wide surgical local excision is however recommended as the most important therapeutic intervention. We report a case of a HIV-infected man who developed a voluminous pelvic BLT which disappeared progressively under antiretroviral therapy with no additional treatment, contemporary to an improvement of his immunity, highlighting the possible spontaneous reversibility of HPV-induced tumours in treated HIV infection. Read More

    Cutaneous Sebaceous Lesions in a Patient With MUTYH-Associated Polyposis Mimicking Muir-Torre Syndrome.
    Am J Dermatopathol 2016 Dec;38(12):915-923
    *Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Prague, Czech Republic; †Bioptical Laboratory, Pilsen, Czech Republic; and ‡Department of Dermatology, Regional Hospital, Sumperk, Czech Republic.
    A 76-year-old white male with a history of adenocarcinoma of the rectosigmoideum and multiple colonic polyps removed at the age of 38 and 39 years by an abdominoperitoneal amputation and total colectomy, respectively, presented with multiple whitish and yellowish papules on the face and a verrucous lesion on the trunk. The lesions were surgically removed during the next 3 years and a total of 13 lesions were investigated histologically. The diagnoses included 11 sebaceous adenomas, 1 low-grade sebaceous carcinoma, and 1 squamous cell carcinoma. Read More

    Interventional laser surgery for oral potentially malignant disorders: a longitudinal patient cohort study.
    Int J Oral Maxillofac Surg 2017 Mar 17;46(3):337-342. Epub 2016 Nov 17.
    Department for Health, University of Bath, Bath, Somerset, UK.
    Oral squamous cell carcinoma (OSCC) is a lethal disease, with rising incidence. There were 6767 new OSCC cases and 2056 deaths in the UK in 2011. Cancers are preceded by oral potentially malignant disorders (PMDs), recognizable mucosal diseases harbouring increased SCC risk, offering clinicians a 'therapeutic window' to intervene. Read More

    Exophytic Verrucous Hyperplasia of the Oral Cavity – Application of Standardized Criteria for Diagnosis from a Consensus Report
    Asian Pac J Cancer Prev 2016 Jan;17(9):4491
    Stomatology Unit, Institute for Medical Research, Kuala Lumpur, Malaysia
    Verruco-papillary lesions (VPLs) of the oral cavity described in the literature involve a spectrum of conditions including squamous papilloma, verruca vulgaris, focal epithelial hyperplasia, condyloma, proliferative verrucous leukoplakia and verrucous carcinoma. A majority of the VPLs are slow growing, benign in nature and have a viral aetiology. Virus associated benign mucosal outgrowths are not too difficult to diagnose either clinically or by microscopy. Read More

    Giant Perineal Condyloma Acuminatum (Buschke-Lowenstein Tumour): A Case Report.
    Chirurgia (Bucur) 2016 Sept-Oct;111(5):435-438
    The giant condyloma acuminatum, also known as Buschke- Lowenstein tumor (BLT), is a rare sexually-transmitted disease. Moreover, the condyloma acuminatum produced by Human Papilloma Virus (HPV) infection becomes one the most common sexually-transmitted infection which affects the perineal region. Under such situations, the first therapeutic option is surgical excision. Read More

    Metastatic Urothelial Carcinoma to the Uterine Cervix: A Case Report of a Rare Entity and Review of the Diagnostic Differential.
    Int J Gynecol Pathol 2016 Oct 31. Epub 2016 Oct 31.
    Department of Pathology (S.B.S., J.A.R.), University of Colorado, Denver, Aurora, Colorado.
    Urothelial carcinoma (UC) rarely metastasizes to the gynecologic tract, occurring in descending order of frequency, within the vagina, uterus, ovaries, and cervix. Significant morphologic overlap exists between primary gynecologic squamous lesions (both benign and malignant) and metastatic UC, thus potentially hindering a timely and accurate diagnosis. We present a case of UC metastatic to the uterine cervix in a 69-year-old female initially found to have noninvasive high-grade papillary UC of the bladder. Read More

    Utility of Superiorly Based Masseter Muscle Flap for Postablative Retromaxillary Reconstruction.
    J Oral Maxillofac Surg 2017 Jan 17;75(1):224.e1-224.e9. Epub 2016 Sep 17.
    Senior Resident, Department of Oral and Maxillofacial Surgery, Swargiya Dadasaheb Kalmegh Smruti Dental College and Hospital, Hingana, Nagpur, India.
    Purpose: Resections in the posterior component of the oral cavity usually lead to severe functional compromise and lower quality of life for patients. Notable advances in reconstruction of the posterior part of the mouth and of the oropharynx have occurred in recent decades. The anatomic and physiologic rehabilitation of the defect to a reasonable outcome with low morbidity and mortality remains the founding basis of any surgical reconstruction, which also holds true for oral oropharyngeal and retromaxillary reconstructions. Read More

    Exophytic oral verrucous hyperplasia: a new entity.
    J Investig Clin Dent 2016 Nov 15;7(4):417-423. Epub 2015 Jun 15.
    Department of Oral Pathology and Microbiology, Faculty of Dental Sciences, M. S. Ramaiah University of Applied Sciences, Bangalore, India.
    Objective: Exophytic oral verrucous hyperplasia (OVH) is a new entity described by an expert working group from South Asia. First reported in Taiwan, there are no reports so far from an Indian population. The aim was to use the microscopic features described by the expert group to differentiate OVH from other oral verruco-papillary lesions in an Indian archive. Read More

    Verrucous Squamous Cell Cancer in the Esophagus: An Obscure Diagnosis.
    Case Rep Gastroenterol 2016 May-Aug;10(2):466-471. Epub 2016 Aug 31.
    Department of Surgical Gastroenterology C, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark.
    Verrucous carcinoma is a rare, slow-growing type of squamous cell cancer. Fewer than 50 patients with verrucous carcinoma in the esophagus have been described worldwide. In 2014, two male patients were diagnosed with verrucous carcinoma in the distal part of the esophagus. Read More

    Oral verrucous hyperplasia versus oral verrucous carcinoma: A clinicopathologic dilemma revisited using p53 as immunohistochemical marker.
    J Oral Maxillofac Pathol 2016 Sep-Dec;20(3):362-368
    Department of Periodontics, Subharti Dental College, Meerut, Uttar Pradesh, India.
    Background: Oral verrucous hyperplasia (OVH) and oral verrucous carcinoma (OVC) are two distinct clinicopathologic verrucous lesions. However, the distinction between the two lesions still remains enigmatic. It is almost impossible to distinguish them clinically. Read More

    Cancer-associated fibroblasts are an infrequent finding in the microenvironment of proliferative verrucous leukoplakia-associated squamous cell carcinoma.
    J Oral Pathol Med 2016 Sep 29. Epub 2016 Sep 29.
    Department of Pathology, Rambam Medical Center, Bat Galim, Haifa, Israel.
    Background: Cancer-associated fibroblasts (CAFs) are generally associated with negative prognostic factors. This study compares the clinicopathologic impact of CAFs in oral squamous cell carcinoma in patients with a history of proliferative verrucous leukoplakia (p-scca) and patients with conventional squamous cell carcinoma of the buccal mucosa, gingiva, and palate (c-scca).

    Methods: A retrospective clinicopathologic and immunohistochemical analysis of 97 tumor specimens from 78 patients (13 patients with proliferative verrucous leukoplakia-associated squamous cell carcinoma (n = 32) and conventional squamous cell carcinoma from the buccal mucosa, gingiva, and palate (n = 65) was conducted. Read More

    p16 - a Possible Surrogate Marker for High-Risk Human Papillomaviruses in Oral Cancer?
    Asian Pac J Cancer Prev 2016 ;17(8):4049-57
    Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand E-mail :
    Background: High-risk human papillomaviruses (HR-HPV), particularly types 16 and 18, have been found to play an important role in head and neck cancer, including oropharyngeal squamous cell carcinoma (OPSCC) and oral squamous cell carcinoma (OSCC). p16, a cell cycle inhibitor, has been postulated as a surrogate marker for HR-HPV, since p16 is aberrantly overexpressed in such lesions, especially in HR-HPV-positive OPSCC. However, p16 as a surrogate marker for HR-HPV infection in cancers of the oral cavity remains controversial. Read More

    Minor Salivary Gland Changes in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma - A Histopathological Study.
    J Clin Diagn Res 2016 Jul 1;10(7):ZC12-5. Epub 2016 Jul 1.
    Professor and Head, Department of Oral Pathology, Sree Moogambigai Dental College , Kulasekharam, Tamil Nadu, India .
    Introduction: The most common etiology for Oral Squamous Cell Carcinoma (OSCC) is tobacco and tobacco related products which cause nuclear damage to the keratinocytes. The chemical carcinogens not only affect the lining of oral epithelium but also affect the lining epithelium of the excretory ducts of the salivary glands. Thus, there is a possibility of epithelial dysplasia of the salivary duct epithelium which may lead to potential malignant transformation. Read More

    Intraosseous verrucous carcinoma arising from an orthokeratinized odontogenic keratocyst: A report of a rarest entity.
    Contemp Clin Dent 2016 Jul-Sep;7(3):416-9
    Department of Oral Medicine and Radiology, Subharti Dental College, Meerut, Uttar Pradesh, India.
    Intraosseous verrucous carcinomas (VCs) arising from odontogenic cysts are a rare entity. An unusual case of a VC arising from the orthokeratinized odontogenic cyst is described for the first time. The microscopic features of the lesion are presented. Read More

    Verrucous carcinoma-an enigma: Case report and review.
    Contemp Clin Dent 2016 Jul-Sep;7(3):391-3
    Department of Oral Medicine and Radiology, College of Dental Sciences, Davangere, Karnataka, India.
    Verrucous hyperplasia, verrucous keratosis, and VC may not be distinguished clinically or may coexist. Though it appears remarkably harmless, the histopathological diagnosis of VC should be accompanied with careful identification of tumors with a greater chance to become frank cancers. Here, we report two cases of OVC, referring all the diagnostic intricacy occurring in the clinicopathological examination along with a review of the scientific literature. Read More

    Tumors and Tumorlike Conditions of the Anal Canal and Perianal Region: MR Imaging Findings.
    Radiographics 2016 Sep-Oct;36(5):1339-53
    From the Department of Radiology, University of Texas Health Science Center, 6431 Fannin St, MSB 2.130, Houston, TX 77030 (V.R.S.); Department of Radiology, Mayo Clinic, Scottsdale, Ariz (C.O.M., A.K.H.); Department of Radiology, University of Texas MD Anderson Cancer Center, Houston, Tex (A.M.A., M.E., K.M.E.); Department of Radiology, University of Texas Health Science Center, San Antonio, Tex (V.S.K.); Department of Radiology, MetroHealth Medical Center, Cleveland, Ohio (W.C.B.); Department of Radiology, University of Ottawa, Ottawa, Ontario, Canada (A.K.); and Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Mo (C.L.S.).
    Tumors and tumorlike conditions of the anus and perianal region originate from the anal canal and anal margin or result from direct extension of tumors from adjacent organs. The anatomy of the anal canal is complex, and its different histologic characteristics can lead to diverse pathologic conditions. The anal canal extends from the anorectal junction to the anal verge. Read More

    Investigation of the association between miR‑181b, Bcl‑2 and LRIG1 in oral verrucous carcinoma.
    Mol Med Rep 2016 Oct 9;14(4):2991-6. Epub 2016 Aug 9.
    Department of Oral and Maxillofacial Surgery, Xiangya School and Hospital of Stomatology, Central South University, Changsha, Hunan 410078, P.R. China.
    Abnormal expression of microRNAs (miRNAs) is involved in the development of and anti‑apoptotic effects in various types of human cancer. However, miRNA‑mediated regulation of oral verrucous carcinoma (OVC) remains to be elucidated. The present study aimed to investigate the expression of miR‑181b in OVC and oral squamous cell carcinoma (OSCC). Read More

    Clinicopathological and Immunohistochemical Characteristics of Verruciform Xanthoma of the Lower Gingiva: A Case Report.
    J Clin Diagn Res 2016 Jun 1;10(6):ZD05-6. Epub 2016 Jun 1.
    Director, Department of Dentistry Oral and Maxillofacial Surgery, Ogaki Municipal Hospital , 4-86 Minaminokawa-cho, Ogaki, Gifu, Japan .
    Verruciform xanthoma (VX) is a rare benign lesion and mainly effects the oral mucosa. This slow-growing asymptomatic lesion typically develops along the gingival margin of the masticatory mucosa, followed by the hard palate, tongue, buccal mucosa, floor of the mouth, alveolar mucosa, soft palate and junction between the hard and soft palate. Moreover, this lesion can also affect the skin and genital organs. Read More

    Laryngeal Verrucous Carcinoma.
    Otolaryngol Head Neck Surg 2017 Jan 9;156(1):38-45. Epub 2016 Aug 9.
    1 Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
    Objective Laryngeal verrucous carcinoma (LVC) is a rare, locally invasive neoplasm comprising 1% to 3.4% of laryngeal carcinomas. Management strategies are a topic of ongoing conversation, and no definitive treatment protocol based on T stage and presentation exists. Read More

    A proteomic approach to compare saliva from individuals with and without oral leukoplakia.
    J Proteomics 2017 Jan 29;151:43-52. Epub 2016 Jul 29.
    Oral Pathology, Federal Fluminense University (UFF), R. Marques de Paraná, 303/4° andar (Hospital Universitário Antônio Pedro), Centro Niterói, Brazil, CEP: 24033-900. Electronic address:
    Background: Oral leukoplakia is the most common potentially malignant disorder in the oral cavity and can precede carcinoma. This study aimed to identify possible oral leukoplakia salivary biomarkers.

    Methods: Unstimulated saliva was collected from participants and protein concentration was determined. Read More

    Cutaneous Squamous Cell Carcinoma: A Review of High-Risk and Metastatic Disease.
    Am J Clin Dermatol 2016 Oct;17(5):491-508
    Veterans Affairs Medical Center Brooklyn, 800 Poly Place, Brooklyn, NY, 11209, USA.
    Non-melanoma skin cancer represents one-third of all malignancies and its incidence is expected to rise until the year 2040. Cutaneous squamous cell carcinoma (cSCC) represents 20 % of all non-melanoma skin cancer and is a deadly threat owing to its ability to metastasize to any organ in the body. Therefore, a better understanding of cSCC is essential to strengthen preventative measures and curable treatment options. Read More

    Recurrent verrucous carcinoma of the urinary bladder after transurethral resection followed by intravesical mitomycin, and a review of the literature.
    BMJ Case Rep 2016 Jun 15;2016. Epub 2016 Jun 15.
    Department of Pathology, Shifa International Hospital Islamabad, Islamabad, Pakistan.
    Verrucous carcinoma (VC) is a locally invasive, non-metastasising well differentiated variant of squamous cell carcinoma. It is very rare in the urinary bladder and mostly associated with schistosomiasis. It has a characteristic multilobular appearance with small surface projections on contrast cystogram. Read More

    Verruciform xanthoma of the lip: A rarity.
    Indian Dermatol Online J 2016 May-Jun;7(3):180-2
    Department of Oral and Maxillofacial Pathology and Microbiology, DY Patil School of Dentistry, Navi Mumbai, Maharashtra, India.
    Verruciform xanthoma (VX) is an uncommon, benign, asymptomatic mucocutaneous lesion of an unknown etiopathology. It usually presents as a papule or single plaque with a verrucous or a papillomatous surface and pale yellowish to red in color. It occurs primarily on the masticatory mucosa of middle-aged individuals. Read More

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