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    1903 results match your criteria Verrucous Carcinoma

    1 OF 39

    Downregulation of Notch4 - a prognostic marker in distinguishing oral verrucous carcinoma from oral squamous cell carcinoma.
    Braz J Otorhinolaryngol 2017 Oct 31. Epub 2017 Oct 31.
    SRM University, School of Bioengineering, Department of Genetic Engineering, Kattankulathur, India. Electronic address:
    Introduction: Oral verrucous carcinoma is a special form of well-differentiated squamous cell carcinoma which possesses specific clinical, morphologic and cytokinetic features that differ from other types of oral cancers and hence diagnosis requires immense experience in histopathology. Hence it is certainly important to distinguish such a lesion from other oral tumors as treatment strategies vary widely between them.

    Objective: In search of a critical diagnostic marker in distinguishing oral verrucous carcinoma from oral squamous cell carcinoma, Notch4 receptor, one of the key regulatory molecules of the Notch signaling family has been aberrantly activated in the progression of several types of tumors. Read More

    [Keratoacanthomas on recent tattoos: Two cases].
    Ann Dermatol Venereol 2017 Dec 7;144(12):776-783. Epub 2017 Nov 7.
    Consultation « tatouage », service de dermatologie, hôpital Bichat - Claude-Bernard, hôpitaux universitaires Paris-Nord-Val-de-Seine, 46, rue Henri-Huchard, 75018 Paris, France.
    Background: Increasing numbers of reports of rapidly arising, isolated or eruptive keratoacanthomas (KA) and squamous cell carcinomas (CSC) on the red part of tattoos tend to suggest a non-fortuitous link with the procedure. We report herein two different presentations of KAs on tattoos: one patient with multiple eruptive KAs on sun-exposed areas of a recent red tattoo and another with a solitary lesion on a recent tattoo. We discuss the issues related to the distinction between KAs and CSCs in this particular context. Read More

    A comparative study of the cutaneous side effects between BRAF monotherapy and BRAF/MEK inhibitor combination therapy in patients with advanced melanoma: a single-centre experience.
    Eur J Dermatol 2017 Oct;27(5):482-486
    Unit of Dermatology, University of Padua, Via Gallucci 4, 35128 Padova, Italy.
    Patients with advanced melanoma have a poor prognosis. Since the discovery of BRAF mutations in cutaneous melanoma, new pharmacological agents have been developed to inhibit this target. Although the survival of patients with advanced melanoma has improved with BRAF inhibitors, the emergence of drug resistance and the high incidence of cutaneous side effects represent important limitations. Read More

    A report on the clinical-pathological correlations of 788 gingival lesion.
    Med Oral Patol Oral Cir Bucal 2017 Nov 1;22(6):e686-e693. Epub 2017 Nov 1.
    Department of Surgical Sciences, University of Turin, CIR - Dental School, Oral Medicine Section, Via Nizza 230, 10126 Turin, Italy,
    Background: The diagnosis and treatment of a variety of non-plaque related gingival diseases have become an integrated aspect of everyday dentistry. The aim of this study was to analyse the relationship between clinical appearance and histopathological features of gingival lesions in a large Northern Italian population.

    Material And Methods: A retrospective study of 788 cases of gingival and alveolar mucosal biopsies was set up. Read More

    Chromoblastomycosis of the leg.
    Pol J Pathol 2017;68(2):182-184
    Case Report: We herein report a case of chromoblastomycosis presenting as a verrucous lesion over the leg. A 56-year-old male patient was a known case of carcinoma larynx and was treated for the same. At presentation to our hospital, the patient, in addition to the recurrent local disease, was suspected to have second primary in the form of verrucous carcinoma of the leg. Read More

    The Spectrum of Oral Lesions Presenting Clinically With Papillary-Verrucous Features.
    J Oral Maxillofac Surg 2017 Aug 24. Epub 2017 Aug 24.
    Professor and Oral Pathologist, Goldschleger School of Dental Medicine and Sackler School of Medicine, Tel Aviv University, and Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
    Purpose: We sought to study the spectrum of oral pathologies presenting clinically with papillary-verrucous features.

    Materials And Methods: A 10-year (2007 to 2016) retrospective study of oral papillary lesions was undertaken. All biopsy reports that included a clinical description of papillary or verrucous architecture were retrieved. Read More

    Simultaneous Development of Three Different Neoplasms of Trichilemmoma, Desmoplastic Trichilemmoma and Basal Cell Carcinoma Arising from Nevus Sebaceus.
    Arch Craniofac Surg 2017 Mar 25;18(1):46-49. Epub 2017 Mar 25.
    Department of Pathology, Busan-Baik Hospital, Inje University School of Medicine, Busan, Korea.
    Nevus sebaceus is a hamartoma of the sebaceous gland that occurs congenitally, from which various secondary tumors can arise with a prevalence of 5%-6%. Benign neoplasms commonly arise from nevus sebaceous, but they have a very low malignant potential. Two neoplasms may occasionally arise within the same lesion, but it is rare for three or more neoplasms to occur in a nevus sebaceus simultaneously. Read More

    A case of reccuring giant condyloma of vulva in infant without sexual abuse successfully treated with electrocoagulation in Benin.
    Pan Afr Med J 2017 30;27:159. Epub 2017 Jun 30.
    Dermatology-Venereology, Faculty of Health, Cotonou, University of Abomey-Calavi, R. Benin.
    We report here a case of giant vulval condyloma in a two-year-old infant infected by her "baby sitter" without sexual abuse. Treated by surgical excision coupled with electrocoagulation, it was noted a rapid recurrence two weeks after treatment requiring a second electrocoagulation session. More than a year later, no lesion was noted, thus demonstrating therapeutic success. Read More

    Epidemiology and survival outcomes of sinonasal verrucous carcinoma in the United States.
    Laryngoscope 2017 Sep 2. Epub 2017 Sep 2.
    Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California, U.S.A.
    Introduction: Verrucous carcinoma (VC) is a rare, variant of squamous cell carcinoma with benign cytohistopathologic features and a generally favorable prognosis. Epidemiologic and clinical outcomes data are lacking as a result of limited cases of sinonasal VC.

    Objective: To describe the incidence and determinants of survival of patients with verrucous carcinoma of the sinonasal tract between the years of 1973 to 2014 using the Surveillance, Epidemiology, and End Results (SEER) database. Read More

    A population-based analysis of verrucous carcinoma of the oral cavity.
    Laryngoscope 2017 Aug 29. Epub 2017 Aug 29.
    Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA; the UCLA Head and Neck Cancer Program.
    Objectives: To describe the incidence and determinants of survival of patients with verrucous carcinoma (VC) of the oral cavity between the years of 1973 and 2012 using the Surveillance, Epidemiology, and End Results (SEER) database.

    Study Design: Retrospective cohort study using a national database.

    Methods: The SEER registry was utilized to calculate survival trends for patients with VC of the oral cavity between 1973 and 2012. Read More

    CpG location and methylation level are crucial factors for the early detection of oral squamous cell carcinoma in brushing samples using bisulfite sequencing of a 13-gene panel.
    Clin Epigenetics 2017 15;9:85. Epub 2017 Aug 15.
    "M. Malpighi" Section of Anatomic Pathology, Department of Biomedical and Neuromotor Sciences, Bellaria Hospital, University of Bologna, via Altura n.3, 40137 Bologna, Italy.
    Background: Oral squamous cell carcinoma (OSCC) is usually diagnosed at an advanced stage and is commonly preceded by oral premalignant lesions. The mortality rates have remained unchanged (50% within 5 years after diagnosis), and it is related to tobacco smoking and alcohol intake. Novel molecular markers for early diagnosis are urgently needed. Read More

    Acquired epidermodysplasia verruciformis occurring in a renal transplant recipient.
    Cutis 2017 May;99(5):E9-E12
    Department of Dermatology, Geisinger Medical Center, Danville, Pennsylvania, USA.
    Acquired epidermodysplasia verruciformis (EDV) is a rare condition occurring in patients with depressed cellular immunity, particularly individuals with human immunodeficiency virus (HIV). Acquired EDV is less commonly reported in recipients of stem cell or solid organ transplantation. This condition typically manifests within 5 years of initial immunosuppression and can present as multiple hypopigmented to red, tinea versicolor-like macules or as multiple verrucous, flat-topped papules distributed over the trunk, arms, and legs. Read More

    Research on miRNA-195 and target gene CDK6 in oral verrucous carcinoma.
    Cancer Gene Ther 2017 Jul 16;24(7):282-288. Epub 2017 Jun 16.
    Department of oral and maxillofacial surgery, Central South University &Xiangya Stomatology Hospital, Changsha, Hunan Province, China.
    Oral verrucous carcinoma (OVC) is a verrucous variant of oral cavity squamous carcinoma (OSCC). The expression of miRNA from OVC and OSCC including their matched normal oral mucosa tissues was profiled through the Affymetrix GeneChip miRNA Arrays. TargetScan and miRanda databases were used to predict the target gene of miRNA-195. Read More

    Human Papilloma Virus-Associated Lips Verrucous Carcinoma in HIV-Infected Male.
    J Int Assoc Provid AIDS Care 2017 Jul/Aug;16(4):324-326. Epub 2017 Jun 1.
    3 Department of Dermatology, "Santa Maria della Misericordia" Hospital, University of Perugia, Perugia, Italy.
    Human papillomavirus (HPV) infection, widely known as the necessary cause of cervical cancer, has been established as a major etiologic factor for head and neck cancer (HNC). HIV-infected individuals are at higher risk of HPV-associated cancers than the general population. We describe a 45-year-old man with HIV and HPV coinfection, who presented progressively enlarging verrucous neoformations of the lips. Read More

    Dermoscopic Analysis of Nevus Sebaceus of Jadassohn: A Study of 13 Cases.
    Skin Appendage Disord 2017 May 16;3(2):83-91. Epub 2017 Mar 16.
    Department of Dermatology, University Hospital Hassan II, Fez, Morocco.
    Background: Nevus sebaceus of Jadassohn (NSJ) is a complex cutaneous hamartoma with various clinical appearances.

    Aim: To describe different dermoscopic patterns of this nevus according to its evolutionary stages.

    Methods: This was an analytical study of NSJ carried out in the Department of Dermatology at the University Hospital Hassan II, Fez, Morocco. Read More

    Comorbidity between HTLV-1-associated adult T-cell lymphoma/leukemia and verrucous carcinoma: a case report.
    Colomb Med (Cali) 2017 Mar 30;48(1):35-38. Epub 2017 Mar 30.
    Escuela de Medicina Facultad de Salud, Universidad del Valle Cali, Colombia.
    Background: Adult T-cell Leukemia/Lymphoma (ATLL) is classified as a peripheral CD4+ T-cell neoplasm caused by the human T-cell lymphotropic virus type 1 (HTLV-1). Typical symptoms are associated with leukemic infiltration; however, atypical and exaggerated manifestations of verrucous carcinoma have also been described.

    Case Report: We present here the case of a patient with multiple skin lesions, ischemic necrosis in the hallux and lymphadenopathies. Read More

    Verrucous carcinoma of the vulva: diagnosis and treatment.
    An Bras Dermatol 2017 Mar-Apr;92(2):243-245
    Dermatology Clinic at Irmandade da Santa Casa de Misericórdia de São Paulo - São Paulo (SP), Brazil.
    Vulvar cancer accounts for less than 1% of malignancies in women. Verrucous carcinoma of the vulva is a rare histological variation, comprising less than 1% of vulvar cancer cases. Although it is characterized as being locally invasive, the condition is not associated with metastatic spreading. Read More

    Atypical presentations of cutaneous leishmaniasis: A systematic review.
    Acta Trop 2017 Aug 17;172:240-254. Epub 2017 May 17.
    Laboratory of Microbiology and Parasitology, Faculty of Medicine, Federal University of Cariri, UFCA, Barbalha, Ceará, Brazil. Electronic address:
    Cutaneous Leishmaniasis (CL) is endemic in 88 countries, showing relevant prevalences. The aim of this study was to perform a systematic review on atypical lesions of CL around the world, addressing clinico-epidemiological, immunological and therapeutic aspects. A search of the literature was conducted via electronic databases Scopus and PubMed for articles published between 2010 and 2015. Read More

    A Giant Cutaneous Horn Projecting from Verrucous Carcinoma of Buccal Mucosa: A Rare Case Report.
    J Clin Diagn Res 2017 Mar 1;11(3):ZD04-ZD05. Epub 2017 Mar 1.
    Reader, Department of Conservative Dentistry and Endodontics, Patna Dental College and Hospital, Patna, Bihar, India.
    Cutaneous horn is conical shape of compact keratin that resembles a miniature animal horn. Though morphologically similar to horns in animals they are histologically very different from them. It is a circumscribed, conical, hyperkeratotic dense protrusion with epithelial cornification above the skin surface in response to a wide range of underlying benign and malignant pathological changes. Read More

    Good Prognosis Went Badly: Fulminant Evolution of a 29-Year-Old Patient with Verrucous Carcinoma of the Cervix.
    J Adolesc Young Adult Oncol 2017 Sep 12;6(3):499-502. Epub 2017 May 12.
    2 University of Medicine and Pharmacy "Carol Davila ," Bucharest, Romania .
    Verrucous carcinoma (VC) is a very rare variant of squamous cell carcinoma of the cervix, difficult to point out in histology because of its benign appearance. We present the case of a 29-year-old woman with a locally advanced cervical VC who underwent radiotherapy followed by radical hysterectomy. After local relapse and despite pelvic exenteration, her condition deteriorated. Read More

    Photodynamic treatment outcomes of potentially-malignant lesions and malignancies of the head and neck region: A systematic review.
    J Investig Clin Dent 2017 May 8. Epub 2017 May 8.
    Department of Conservative and Endodontics, HSRS Dental College and Hospital, Hingoli, Maharashtra, India.
    Aim: The aim of the present study was to systematically review the efficacy of photodynamic therapy (PDT) in the management of oral potentially-malignant disorders (PMDS) and head and neck squamous cell carcinoma (HNSCC).

    Methods: From 1985 to 2015, PubMed/Medline, Google Scholar, EMBASE, and ISI Web of Knowledge were searched using different combinations of the following key words: PDT, oral precancer, leukoplakia, erythroplakia, erythroleukoplakia, verrucous hyperplasia, oral submucous fibrosis, and HNSCC. Review articles, experimental studies, case reports, commentaries, letters to the editor, unpublished articles, and articles published in languages other than English were excluded. Read More

    Local Excision for the Treatment of Penile Verrucous Carcinoma.
    Urol Case Rep 2017 Jul 10;13:16-18. Epub 2017 Apr 10.
    Department of Urology, Konkuk University School of Medicine, Chungju, Republic of Korea.
    Penile verrucous carcinoma is known for its favorable biologic behavior and lack of metastatic potential. For preservation of function, treatment has been focused on partial penectomy. Despite partial penectomy for preservation of minimal functional and aesthetic aspects, patients have experienced psychosexual problems. Read More

    Verrucous Hyperplasia: Case report and differential diagnosis.
    Sultan Qaboos Univ Med J 2017 Feb 30;17(1):e98-e102. Epub 2017 Mar 30.
    Department of Periodontics, Christian Dental College & Hospital, Ludhiana, Punjab, India.
    Verrucous hyperplasia (VH) is a rare exophytic oral mucosal lesion which can transform into verrucous carcinoma (VC), its malignant but clinically similar counterpart. These entities can be distinguished by the lack of invasive growth in VH cases; as such, it is essential to include a margin with adequate depth when performing a biopsy of the epithelium of the lesion. We report an 80-year-old male patient who presented to the Bapuji Dental College & Hospital, Davangere, Karanataka, India, in 2011 with a warty whitish-pink growth on the inside of his cheek. Read More

    Pseudoepitheliomatous keratotic and micaceous balanitis treated with topical 5-fluorouracil and liquid nitrogen.
    Clin Exp Dermatol 2017 Apr 13. Epub 2017 Apr 13.
    Dermatology Department, National Skin Centre, Singapore.
    Pseudoepitheliomatous keratotic and micaceous balanitis (PKMB) is an uncommon premalignant condition involving the glans penis. We report the case of an 86-year-old man who presented with phimosis and pain on retracting his foreskin. He had previously undergone circumcision, which revealed a hyperkeratotic plaque with thin mica-like scales involving his glans penis. Read More

    Rare "Inverted" Verrucous Carcinoma (Carcinoma Cuniculatum) of the Sacrogluteal Region: Case Report and Literature Review.
    Int J Surg Pathol 2017 Aug 1;25(5):438-442. Epub 2017 Feb 1.
    1 Royal Hobart Hospital, Hobart, Tasmania, Australia.
    A 49-year-old woman with a past history of several infundibular cysts in the head and neck region presented with a 6-month history of a nonhealing perianal abscess on a background of 13 years of chronic sacral-buttock abscesses and discharging sinuses as part of hidradenitis suppurativa. After 2 surgical procedures and inadequate healing, a wide local excision was performed. The surgical specimen revealed an extensive, infiltrating, cystic and deeply penetrating, dermal and subcutaneous neoplasm with multiple fistulous tracts extending to the skin surface. Read More

    How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?
    Eur Arch Otorhinolaryngol 2017 Jul 31;274(7):2709-2726. Epub 2017 Mar 31.
    International Head and Neck Scientific Group, Padua, Italy.
    Although the majority of laryngeal malignancies are the conventional squamous cell carcinomas (SCC), a wide variety of malignant epithelial tumors can affect the larynx. Current treatment guidelines are designed to guide clinicians in management of conventional laryngeal SCC. Less is known about the biological behavior and responsiveness to therapy and overall outcomes of other malignant epithelial lesions. Read More

    Verrucoid Variant of Invasive Squamous Cell Carcinoma in Oral Submucous Fibrosis: A Clinicopathological Challenge.
    Cureus 2016 Nov 4;8(11):e862. Epub 2016 Nov 4.
    Department of Oral Pathology, Thai Moogambigai Dental College and Hospital.
    Verrucous carcinoma (VC) is an exophytic, low-grade, well-differentiated variant of squamous cell carcinoma. It is described as a lesion appearing in the sixth or seventh decade of life that has minimal aggressive potential and, in long-standing cases, has been shown to transform into squamous cell carcinoma. Oral submucous fibrosis (OSMF) is a potentially malignant disorder, and about one-third of the affected population develop oral squamous cell carcinoma. Read More

    Topical agents for oral cancer chemoprevention: A systematic review of the literature.
    Oral Oncol 2017 Apr 2;67:153-159. Epub 2017 Mar 2.
    Department of Otolaryngology - Head and Neck Surgery, Wayne State University School of Medicine, Detroit, MI, USA; Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA; Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA; Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA.
    Objectives/hypothesis: We review the use of topical chemoprevention agents in patients with oral potentially malignant disorders (PMD).

    Methods: A systematic review of studies on topical chemoprevention agents for oral PMD from 1946 to November 2016 was conducted using the MEDLINE database, Embase, and Cochrane Library. Data were extracted and analyzed from selected studies including study type, sample size, demographics, treatment length, response rate, follow-up time, adverse effects, and recurrence. Read More

    Keratoacanthoma en plaque/nodule: A brief report of the clinicopathological features of five cases.
    J Dermatol 2017 Jul 23;44(7):803-807. Epub 2017 Mar 23.
    Division of Dermatology, Nakao Clinic, Saga, Japan.
    Keratoacanthoma (KA) is characterized by exoendophytic growth with a central keratin-filled crater, representing the crateriform architecture. We herein report five rare cases of KA without a central keratin-filled crater. These KA cases histopathologically showed that one or a few infundibular structures/isthmic lobules had their own open keratotic pores on the surface without a common merged keratotic plug/horn, clinically representing verrucous (keratotic) plaque/nodule, namely, "KA en plaque/nodule". Read More

    Squamous cell carcinoma arising in a multiple verrucous epidermal nevus.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):166-168
    Universidade Federal de São Paulo (UNIFESP) - São Paulo (SP), Brazil.
    Verrucous epidermal nevi are hamartomatous lesions of the epidermis that, unlike other epidermal nevi (such as sebaceous nevus or nevus comedonicus), are rarely associated with malignant neoplasms. The majority of squamous cell carcinoma develop in linear or multiple epidermal nevus and rarely in solitary epidermal nevus. In general, the prognosis is favorable. Read More

    Oral Carcinoma Cuniculatum: A New Entity in the Clinicopathological Spectrum of Oral Squamous Cell Carcinoma.
    J Clin Diagn Res 2017 Jan 1;11(1):ZD37-ZD39. Epub 2017 Jan 1.
    Professor, Department of Oral Pathology and Microbiology, KLE VK Institute of Dental Sciences , Belgaum, Karnataka, India .
    Carcinoma cuniculatum is principally recognized as a variant of carcinoma involving foot. The World Health Organization (WHO) recognizes Oral Carcinoma Cuniculatum (OCC) as a distinct and rare clinicopathological variant of Oral Squamous Cell Carcinoma (OSCC). OCC is confused clinically and histologically with Verrucous Carcinoma (VC) and is often misdiagnosed as either VC or OSCC. Read More

    Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: What is New in the 2017 WHO Blue Book for Tumours of the Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
    Head Neck Pathol 2017 Mar 28;11(1):23-32. Epub 2017 Feb 28.
    Institute of Pathology, Faculty of Medicine, University of Ljubljana, Korytkova 2, 1000, Ljubljana, Slovenia.
    Chapter 3 "Tumours of the hypopharynx, larynx, trachea, and parapharyngeal space" of the World Health Organization (WHO) Blue Book 2017 "Classification of Head and Neck Tumours" shows a shortened list of entities, especially due to reducing the number of benign and malignant soft tissue tumours, malignant melanoma and some others, which are transferred to more frequently affected regions of the head and neck. The basic concept of the new edition is to assimilate all advances concerning the discussed tumours in a shorter framework, appropriate for daily work. The main emphasis is on the most frequent lesions and tumors originating from the covering squamous epithelium. Read More

    Update from the 4th Edition of the World Health Organization of Head and Neck Tumours: Tumours of the Oral Cavity and Mobile Tongue.
    Head Neck Pathol 2017 Mar 28;11(1):33-40. Epub 2017 Feb 28.
    Emory University School of Medicine, Atlanta Oral Pathology, 2701 N. Decatur Road, Decatur, GA, 30033, USA.
    There have been several additions and deletions in Chapter 4 on Tumours of the oral cavity and mobile tongue in the 2017 fourth edition of the World Health Organization Classification of Tumours of the Head and Neck. This chapter excludes the oropharynx, which now is a stand-alone chapter acknowledging the uniqueness of the oropharynx from the oral cavity. New entries in Chapter 4 include rhabdomyoma, haemangioma, schwannoma, neurofibroma and myofibroblastic sarcoma in the section titled Soft tissue and neural tumours. Read More

    Proliferative verrucous leukoplakia: diagnosis, management and current advances.
    Braz J Otorhinolaryngol 2017 Sep - Oct;83(5):585-593. Epub 2017 Jan 24.
    Universidade Federal de Santa Catarina (UFSC), Departamento de Patologia, Florianopolis, SC, Brazil. Electronic address:
    Introduction: Proliferative verrucous leukoplakia is a multifocal and progressive lesion of the oral mucosa, with unknown etiology, and commonly resistant to all therapy attempts with frequent recurrences. It is characterized by a high rate of oral squamous cell carcinoma and verrucou carcinoma transformations.

    Objective: To analyze the studies about Proliferative verrucous leukoplakia and develop a concise update. Read More

    Re-evaluation of epidermodysplasia verruciformis: Reconciling more than 90 years of debate.
    J Am Acad Dermatol 2017 Jun 10;76(6):1161-1175. Epub 2017 Feb 10.
    Department of Dermatology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. Electronic address:
    Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by abnormal susceptibility to cutaneous human beta-papillomavirus infections causing persistent flat warts or pityriasis versicolor-like lesions. This generalized verrucous skin disorder resembles generalized verrucosis, but these 2 conditions are distinguished by differences in clinical manifestation and the human papillomavirus types involved. A breakthrough in our understanding of EV was the discovery that homozygous inactivating mutations in TMC6 (EVER1) and TMC8 (EVER2) determine susceptibility to this disorder; however, they have not solved all EV cases fully. Read More

    Warty Carcinoma Penis: An Uncommon Variant.
    Case Rep Pathol 2017 5;2017:2937592. Epub 2017 Jan 5.
    Department of Pathology, Manipal College of Medical Sciences, Pokhara, Nepal.
    Penile carcinoma frequency varies widely in different parts of the world and comprises 1-10% of all the malignancies in males. Majority of the cases of penile carcinoma are squamous cell carcinoma of penis comprising 60% to 70% of all cases. Warty carcinoma of penis is an unusual neoplasm and a variant of penile squamous cell carcinoma comprising 5%-10% of all the variants. Read More

    Laryngeal Dysplasia, Squamous Cell Carcinoma, and Variants.
    Surg Pathol Clin 2017 Mar;10(1):15-33
    Department of Pathology, Southern California Permanente Medical Group, Woodland Hills Medical Center, 5601 De Soto Avenue, Woodland Hills, CA 91367, USA. Electronic address:
    Squamous cell carcinoma (SCC) is a malignant epithelial tumor showing evidence of squamous differentiation. It is the most common malignancy of the larynx, with several variants (verrucous, exophytic or papillary, spindle-cell, basaloid, acantholytic, adenosquamous) recognized, with well-established precursor lesions. Dysplasia is now separated into only low-grade and high-grade categories. Read More

    Adjuvant radiotherapy is not supported in patients with verrucous carcinoma of the oral cavity.
    Laryngoscope 2017 Jun 1;127(6):1334-1338. Epub 2017 Feb 1.
    Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, U.S.A.
    Objective: To analyze the impact of adjuvant radiation therapy (RT) on overall survival (OS) and disease-specific survival (DSS) in patients with verrucous carcinoma (VC) as compared to squamous cell carcinoma (SCC) of the oral cavity.

    Study Design: Cross-sectional population analysis.

    Methods: Cases of nonmetastatic VC/SCC of the oral cavity were extracted from the Surveillance, Epidemiology, and End Results (SEER) database (1988-2013). Read More

    [Buschke-Lowenstein tumors].
    Hautarzt 2017 Mar;68(3):199-203
    Hautklinik, Universitätsklinikum der RWTH-Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland.
    Background: A giant condyloma acuminatum which shows destructive growth but lacking invasion is designated as a Buschke-Lowenstein tumor (BLT).

    Objectives: Classification of the BLT and therapeutic guidelines are provided.

    Materials And Methods: A MEDLINE literature search from 2006-2016 was performed. Read More

    Verruciform xanthoma of the penis: A rare benign lesion that simulates carcinoma.
    Arch Ital Urol Androl 2016 Dec 30;88(4):284-285. Epub 2016 Dec 30.
    Department of Urology, IRCCS San Martino, University of Genova.
    Verruciform xanthoma is a rare and benign condition predominantly affecting the oral cavity, but also skin and female anogenital mucosa. It can be flat, papular-warty or crateriform-cystic. Furthermore it can simulate HPV viral lesion such as condyloma and malignant neoplasia such as verrucous squamous cell carcinoma. Read More

    A clitoral verrucous carcinoma in an area of lichen planus has aggressive features.
    World J Surg Oncol 2017 Jan 6;15(1). Epub 2017 Jan 6.
    Department of Obstetrics and Gynecology, Multidisciplinary Breast Clinic, Gynecological Oncology Unit, Antwerp University Hospital - University of Antwerp, Wilrijkstraat 10, Edegem, 2650, Belgium.
    Background: Verrucous carcinoma of the vulva is extremely rare. It is a slow growing, low malignant variant of a squamous cell carcinoma with a cauliflower appearance. Women with lichen planus have an increased risk of developing vulval cancer. Read More

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