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    1938 results match your criteria Verrucous Carcinoma

    1 OF 39

    Dermatologic Toxicity from Novel Therapy using Antimicrobial Peptide LL-37 in Melanoma: A Detailed Examination of the Clinicopathologic Features.
    J Cutan Pathol 2018 Apr 17. Epub 2018 Apr 17.
    Department of Pathology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA.
    LL-37 is a naturally occurring 37-amino acid that is part of innate immunity in human skin. Preclinical studies have demonstrated that intra-tumoral injections of LL-37 stimulate the innate immune system by activation of plasmacytoid dendritic cells, which mediate tumor destruction. LL-37 intra-tumoral injections have been utilized in a Phase 1 clinical trial for melanoma patients with cutaneous metastases. Read More

    Potentially Malignant Disorders Revisited - The Lichenoid Lesion/ Proliferative Verrucous Leukoplakia Conundrum.
    J Oral Pathol Med 2018 Apr 16. Epub 2018 Apr 16.
    Newcastle University Medicine Malaysia, Iskandar Puteri, Johor, Malaysia.
    Background: Clinically identifiable potentially malignant disorders (PMD) precede oral squamous cell carcinoma development. Oral lichenoid lesions (OLL) and proliferative verrucous leukoplakia (PVL) are specific precursor lesions believed to exhibit both treatment resistance and a high risk of malignant transformation (MT).

    Methods: A retrospective review of 590 PMD patients treated in Northern England by CO laser surgery between 1996 and 2014 was carried out. Read More

    MCM-2 expression differentiates potentially malignant verrucous lesions from oral carcinomas.
    Ann Diagn Pathol 2018 Mar 13;34:72-76. Epub 2018 Mar 13.
    Department of Oral and Maxillofacial Pathology, SDM College of Dental Sciences and Hospital, Dharwad 580 009, Karnataka, India.
    Background: Mcm-2 is a biomarker belonging to Mcm family of proteins which has rarely been used in oral potentially malignant and malignant lesions of the verrucous type. The objective of this study is to assess the expression of Mcm-2 in Normal Oral Mucosa (NM), Verrucous Hyperplasia (VH), Verrucous Carcinoma (VC) and Oral Squamous Cell Carcinoma (OSCC) and compare it with the clinicopathological characteristics.

    Methodology: A total of 70 formalin fixed paraffin embedded tissue samples (10 cases of Normal Mucosa NM- Group A, 10 cases of Verrucous Hyperplasia- VH without Dysplasia- Group B, 10 cases of Verrucous Hyperplasia- VH with Dysplasia- Group C, 20 cases of Verrucous Carcinoma VC-Group D, 20 cases of Oral Squamous Cell Carcinoma OSCC- Group E) were subjected to immunohistochemistry with Mcm-2 antibody. Read More

    BCL-X expression in oral cancer: Comparison between oral squamous cell carcinoma and verrucous carcinoma.
    Indian J Dent Res 2018 Mar-Apr;29(2):196-200
    Department of Oral and Maxillofacial Surgery, Yenepoya Dental College, Yenepoya University, Mangalore, Karnataka, India.
    Background: Verrucous carcinoma (VC) should be considered a distinct clinicopathologic entity different from the more common oral squamous cell carcinoma (OSCC) because of its unique biological behavior. Best way to understand the behavior of these carcinomas is to study them by means of molecular methods, especially in tumor progression tests and Bcl-X is an important antiapoptotic member of the Bcl-2 family and is one of the newest and most useful markers to determine the aggressiveness of many carcinomas. The relationship between this Bcl-X protein and carcinomatous behavior toward it is not studied extensively, which we attempted to evaluate using immunohistochemical analysis in selected carcinomas of the head and neck region. Read More

    Genitogluteal porokeratosis in an HIV-positive man: a case report and review of the literature on genital porokeratosis.
    Dermatol Online J 2018 Mar 15;24(3). Epub 2018 Mar 15.
    Department of Dermatology, University of California San Diego, La Jolla, California.
    Genitogluteal porokeratosis is a disorder of keratinization that may present in men in their fourth decade of life. We describe a 52-year-old human immunodeficiency virus (HIV)-positive man with history of anal squamous cell carcinoma who developed verrucous lesions on the buttocks and genitals. The buttock lesions presented shortly after radiotherapy for anal carcinoma a decade prior, whereas the genital lesions presented three months prior in areas treated with injectable medication for erectile dysfunction. Read More

    Basaloid Follicular Hamartoma: A Case Report and a Novel Cosmetic Treatment.
    J Clin Aesthet Dermatol 2018 Mar 1;11(3):39-41. Epub 2018 Mar 1.
    Dr. Segars is with NSU-COM/Largo Medical Center Dermatology Residency in Largo, Florida.
    Basaloid follicular hamartoma (BFH) is a rare, benign neoplasm of the hair follicle, characterized by multiple brown papules involving the face, scalp, and trunk. It is described by multiple clinical forms, and can present as localized or generalized. Diagnosis is made histologically via biopsy, which is important in order to distinguish BFH from basal cell carcinoma (BCC) or other malignant epithelial neoplasms. Read More

    Oral epithelial dysplasia, atypical verrucous lesions and oral potentially malignant disorders: focus on histopathology.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Mar 1. Epub 2018 Mar 1.
    Emory University School of Medicine, Atlanta Oral Pathology, Decatur, GA, USA. Electronic address:
    The term oral potentially malignant disorders (OPMDs) describes a recognizable group of mucosal diseases that have a risk of progressing to squamous cell carcinoma. Oral leukoplakia, the most common OPMD, has a 1% prevalence and reported malignant transformation rates of 2% to 5%. Other OPMDs include erythroplakia, erythroleukoplakia, submucous fibrosis, lesions of reverse smokers, and inherited genetic disorders, such as Fanconi anemia. Read More

    Proliferative verrucous leukoplakia misdiagnosed as oral leukoplakia.
    J Indian Soc Periodontol 2017 Nov-Dec;21(6):499-502
    Department of Periodontology, Swami Devi Dyal Dental College and Hospital, Barwala, Haryana, India.
    Correct diagnosis of white lesions of the oral cavity is sometimes difficult, because some oral white lesions behave differently and tend to change their appearance with time. Clinicians often wrongly diagnose such lesions as oral leukoplakias and treat simply. Lesions recur and turn malignant. Read More

    Two Cases of Verrucous Carcinoma: Revisiting the Definition.
    J Nippon Med Sch 2018 ;85(1):47-50
    Department of Dermatology, Nippon Medical School.
    Verrucous carcinoma (VC) is an uncommon, distinct type of well-differentiated squamous cell carcinoma. Here we present two cases of VC, one arising from the lower leg and the other from genital skin. Case 1, a female patient, aged 95 years, had a brownish verrucous plaque on her right lower leg. Read More

    Laryngeal Verruca Vulgaris Presenting with Dysphonia: A Case Report.
    Turk Arch Otorhinolaryngol 2017 Dec 1;55(4):184-186. Epub 2017 Dec 1.
    Department of Otorhinolaryngology, Ankara University School of Medicine, Ankara, Turkey.
    Verruca vulgaris is a common skin lesion that is associated with human papilloma virus and is observed on the surface of skin. Verruca vulgaris is rarely seen in mucosal membranes. Atypical locations may be confused with verrucous carcinoma. Read More

    Cutaneous horn: A mask to underlying malignancy.
    J Oral Maxillofac Pathol 2018 Jan;22(Suppl 1):S87-S90
    Department of Oral Pathology, Manubhai Patel Dental College, Vadodara, Gujarat, India.
    Cutaneous horns () are uncommon lesions consisting of keratotic material resembling that of an animal horn. It is a conical- or cylindrical-shaped excessive hyperkeratosis of variable size ranging from few millimeters to several centimeters with a variable in size and shape, such as cylindrical, conical, pointed, transversely or longitudinally corrugated, or curved like a ram's horn. The lesions typically occur in sun-exposed areas, particularly the face, ear, nose, forearms and dorsum of hands. Read More

    Proliferative endophytic lesion of the maxilla: A diagnostic challenge.
    J Oral Maxillofac Pathol 2018 Jan;22(Suppl 1):S82-S86
    Department of Oral Medicine and Radiology, The Oxford Dental College, Bengaluru, Karnataka, India.
    Carcinoma cuniculatum (CC) is an extremely rare neoplasm of the oral cavity. It is essentially a well-differentiated variety of squamous cell carcinoma and shows lower metastasis risk. The histological features of CC can mimic that of papillary squamous cell carcinoma or verrucous carcinoma. Read More

    Pyoderma Gangranosum-Like Blastomycosis.
    J Cutan Med Surg 2018 Feb 1:1203475418760460. Epub 2018 Feb 1.
    3 Wound Care Centre, Women's College Hospital, Toronto, ON, Canada.
    Blastomyces dermatitidis is typically contracted through inhalation of the dimorphic conidia, resulting in pulmonary infection as well as extrapulmonary disease through hematogenous spread. Blastomycosis is considered one of the great mimickers in medicine, with verrucous cutaneous blastomycosis resembling skin malignancy and B dermatitidis pulmonary infections often confused with lung cancer. Cutaneous blastomycosis can also often mimic pyoderma gangrenosum and should be considered in the differential diagnosis in any suspected case. Read More

    A Retrospective 20-Year Analysis of Proliferative Verrucous Leukoplakia and Its Progression to Malignancy and Association with High-risk Human Papillomavirus.
    Head Neck Pathol 2018 Feb 9. Epub 2018 Feb 9.
    Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, 1395 Center Drive, Gainesville, FL, 32610, USA.
    Proliferative verrucous leukoplakia (PVL) is defined as an aggressive, relentless and recalcitrant form of leukoplakia that has a high propensity for malignant transformation. The aim of this study was to evaluate the malignant potential of PVL and determine its possible association with high-risk human papillomavirus (HPV). Twenty cases with a clinical and biopsy proven diagnosis of PVL were collected from the University of Florida Oral Medicine clinic database. Read More

    [A Patient with Lower Lip Verrucous Carcinoma Treated with a Tongue Flap for Functional and Esthetic Reconstruction].
    Gan To Kagaku Ryoho 2017 Nov;44(12):1936-1938
    Dept. of Oral and Maxillofacial Surgery, National Hospital Organization Hamada Medical Center.
    Surgery is generally indicated for the treatment of lower lip carcinoma. However, surgery can lead to esthetic as well as functional issues, with disturbances in eating and articulation. If the defect involves less than one-third of the width of the lower lip, primary closure is possible. Read More

    Squamous cell carcinoma from oral lichen planus: a case report of a lesion with 28 years of evolution.
    J Korean Assoc Oral Maxillofac Surg 2017 Dec 27;43(Suppl 1):S14-S18. Epub 2017 Dec 27.
    Department of Dentistry, Sagrado Coração University, Bauru, Brazil.
    Lichen planus (LP) is a relatively common mucocutaneous disease with autoimmune etiology. Considering its malignancy potential, it is important to define the correct diagnosis, treatment, and clinical follow-up for patients with LP so that the disease is not diagnosed late, thus hindering the chances of curing the disease. This study aims to describe a clinical case of oral squamous cell carcinoma, potentially originated from LP. Read More

    Versatility of Modified Nasolabial Flap in Oral and Maxillofacial Surgery.
    Arch Craniofac Surg 2017 Dec 23;18(4):243-248. Epub 2017 Dec 23.
    Department of Oral & Maxillofacial Surgery, Sri Aurobindo College of Dentistry, Indore, India.
    Background: To evaluate the versatility and reach of modified nasolabial flap used in reconstruction of defects created in and around the oral cavity.

    Methods: A total number of 20 cases were selected. Out of which 13 were males and 7 females. Read More

    Oral Verrucous Carcinoma: Ten Year Experience from a Tertiary Care Hospital in India.
    Indian J Med Paediatr Oncol 2017 Oct-Dec;38(4):452-455
    Department of General Surgery Unit 1 (Including Head and Neck Surgery), Paul Brand Building, Christian Medical College, Vellore, Tamil Nadu, India.
    Background: Verrucous carcinoma of the oral cavity (OVC) is an uncommon variant of oral squamous cell carcinoma (OSCC). The clinical presentation and surgical outcomes of OVC are unique; however, the management protocols for OVC are largely extrapolated from OSCC.

    Objectives: The aim is to study the clinical, histopathological demographics, and outcome of OVC at a tertiary care referral hospital in South India. Read More

    Malignant Transformation of a Site of Prior Diabetic Foot Ulceration to Verrucous Carcinoma: A Case Report.
    Wounds 2017 Dec;29(12):E125-E131
    Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Hospital and Health Systems, Ann Arbor, MI.
    The case of a 62-year-old Caucasian man with type 1 diabetes who developed malignant transformation of an area of prior diabetic foot ulceration (DFU) is reported. He had significant hallux valgus deformity, multiple episodes of healing and breakdown, and eventual transformation to verrucous carcinoma (VC). This case report highlights the malignant transformation of a site of previous DFU to VC, which, to the best of the authors' knowledge, has not yet been described in the literature. Read More

    Modified Cajal's trichrome stain as a diagnostic aid in the study of epithelial pathology.
    Indian J Pathol Microbiol 2017 Oct-Dec;60(4):528-532
    Department of Oral Pathology, Vydehi Institute of Dental Sciences, Bengaluru, Affiliated to Rajiv Gandhi University of Health Sciences, Karnataka, India.
    Background: Diagnosis of initial epithelial pathology maybe difficult in Squamous Cell Carcinoma (SCC), Carcinoma In Situ and other atypical epithelial malignancies, under routine Haematoxylin and Eosin (H and E) stain. The detection of minor basement membrane alterations in doubtful cases is both time consuming and confusing.

    Aims: To evaluate efficacy of Modified Cajal's Trichrome Stain (CTS) in relation to Haematoxylin and Eosin for study of epithelial dysplasia, carcinoma in situ, micro invasive SCC, frank SCC, and SCC in lymph nodes. Read More

    The limitations of dermoscopy: false-positive and false-negative tumours.
    J Eur Acad Dermatol Venereol 2018 Jan 5. Epub 2018 Jan 5.
    First Department of Dermatology, Aristotle University, Thessaloniki, Greece.
    Dermoscopy has been documented to increase the diagnostic accuracy of clinicians evaluating skin tumours, improving their ability to detect skin cancer and better recognize benign moles. However, dermoscopically 'false-positive' and 'false-negative' tumours do exist. False-positive diagnosis usually leads to unnecessary excisions. Read More

    Carcinoma Cuniculatum of the Right Thenar Region with Bone Involvement and Lymph Node Metastases.
    Case Rep Dermatol 2017 Sep-Dec;9(3):225-230. Epub 2017 Nov 10.
    Department of Dermatology, Municipal Hospital Hietzing, Vienna, Austria.
    Squamous cell carcinoma (SCC) is the second most common type of skin cancer after basal cell carcinoma (BCC). The overall prevalence of BCC is 3 times higher than that of SCC, but this can vary when looking at specific locations such as the hand, where SCC is much more common than BCC. Carcinoma (or epithelioma) cuniculatum is a rare variant of SCC. Read More

    Oral manifestation of histoplasmosis on the palate.
    An Bras Dermatol 2017 ;92(5 Suppl 1):107-109
    Department of Conservative Dentistry - Faculdade de Odontologia - Universidade Federal do Rio Grande do Sul (UFRGS) - Porto Alegre (RS), Brazil.
    This case report describes an uncommon manifestation of histoplasmosis on the soft palate. The importance of appropriate treatment and follow-up in complex cases is emphasized, especially in patients with chronic diseases. Oral lesions may occur as multiple, granular and painful ulcers, as well as verrucous growths. Read More

    Acral melanoma foot lesions. Part 2: clinical presentation, diagnosis, and management.
    Clin Exp Dermatol 2018 Mar 13;43(2):117-123. Epub 2017 Dec 13.
    Department of Dermatology, State University of New York Downstate Medical Center, Brooklyn, NY, USA.
    Acral melanoma (AM) is a rare subtype of cutaneous malignant melanoma found on acral skin, primarily on the soles of the feet. Although rare, it is the most common subtype of melanoma found in patients of African or Asian ethnicity and has a poor prognosis, often because of the more advanced stage of presentation at diagnosis. In the second of this two-part series, we review the clinical presentation, histopathology, diagnosis and management of AM. Read More

    [Morphology of non cutaneous head and neck squamous cell carcinoma].
    Pathologe 2018 Feb;39(1):3-10
    Institut für Pathologie, Universitätsklinikum Erlangen, Erlangen, Deutschland.
    Head and neck squamous cell carcinoma (HNSCC) is by far the most frequent malignant tumor in this anatomic region. Today, HNSCC is divided into two morphologically, molecularly and clinically fundamentally different entities: conventional and virus-associated (HPV/EBV) neoplasms. Premalignant lesions of nonvirus-associated HNSCC include conventional leukoplakia, dysplasia and proliferative verrucous hyperplasia with an increasing risk for malignant transformation. Read More

    Downregulation of Notch4 - a prognostic marker in distinguishing oral verrucous carcinoma from oral squamous cell carcinoma.
    Braz J Otorhinolaryngol 2017 Oct 31. Epub 2017 Oct 31.
    SRM University, School of Bioengineering, Department of Genetic Engineering, Kattankulathur, India. Electronic address:
    Introduction: Oral verrucous carcinoma is a special form of well-differentiated squamous cell carcinoma which possesses specific clinical, morphologic and cytokinetic features that differ from other types of oral cancers and hence diagnosis requires immense experience in histopathology. Hence it is certainly important to distinguish such a lesion from other oral tumors as treatment strategies vary widely between them.

    Objective: In search of a critical diagnostic marker in distinguishing oral verrucous carcinoma from oral squamous cell carcinoma, Notch4 receptor, one of the key regulatory molecules of the Notch signaling family has been aberrantly activated in the progression of several types of tumors. Read More

    [Keratoacanthomas on recent tattoos: Two cases].
    Ann Dermatol Venereol 2017 Dec 7;144(12):776-783. Epub 2017 Nov 7.
    Consultation « tatouage », service de dermatologie, hôpital Bichat - Claude-Bernard, hôpitaux universitaires Paris-Nord-Val-de-Seine, 46, rue Henri-Huchard, 75018 Paris, France.
    Background: Increasing numbers of reports of rapidly arising, isolated or eruptive keratoacanthomas (KA) and squamous cell carcinomas (CSC) on the red part of tattoos tend to suggest a non-fortuitous link with the procedure. We report herein two different presentations of KAs on tattoos: one patient with multiple eruptive KAs on sun-exposed areas of a recent red tattoo and another with a solitary lesion on a recent tattoo. We discuss the issues related to the distinction between KAs and CSCs in this particular context. Read More

    A comparative study of the cutaneous side effects between BRAF monotherapy and BRAF/MEK inhibitor combination therapy in patients with advanced melanoma: a single-centre experience.
    Eur J Dermatol 2017 Oct;27(5):482-486
    Unit of Dermatology, University of Padua, Via Gallucci 4, 35128 Padova, Italy.
    Patients with advanced melanoma have a poor prognosis. Since the discovery of BRAF mutations in cutaneous melanoma, new pharmacological agents have been developed to inhibit this target. Although the survival of patients with advanced melanoma has improved with BRAF inhibitors, the emergence of drug resistance and the high incidence of cutaneous side effects represent important limitations. Read More

    A report on the clinical-pathological correlations of 788 gingival lesion.
    Med Oral Patol Oral Cir Bucal 2017 Nov 1;22(6):e686-e693. Epub 2017 Nov 1.
    Department of Surgical Sciences, University of Turin, CIR - Dental School, Oral Medicine Section, Via Nizza 230, 10126 Turin, Italy,
    Background: The diagnosis and treatment of a variety of non-plaque related gingival diseases have become an integrated aspect of everyday dentistry. The aim of this study was to analyse the relationship between clinical appearance and histopathological features of gingival lesions in a large Northern Italian population.

    Material And Methods: A retrospective study of 788 cases of gingival and alveolar mucosal biopsies was set up. Read More

    Chromoblastomycosis of the leg.
    Pol J Pathol 2017;68(2):182-184
    Case Report: We herein report a case of chromoblastomycosis presenting as a verrucous lesion over the leg. A 56-year-old male patient was a known case of carcinoma larynx and was treated for the same. At presentation to our hospital, the patient, in addition to the recurrent local disease, was suspected to have second primary in the form of verrucous carcinoma of the leg. Read More

    The Spectrum of Oral Lesions Presenting Clinically With Papillary-Verrucous Features.
    J Oral Maxillofac Surg 2018 Mar 24;76(3):545-552. Epub 2017 Aug 24.
    Professor and Oral Pathologist, Goldschleger School of Dental Medicine and Sackler School of Medicine, Tel Aviv University, and Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
    Purpose: We sought to study the spectrum of oral pathologies presenting clinically with papillary-verrucous features.

    Materials And Methods: A 10-year (2007 to 2016) retrospective study of oral papillary lesions was undertaken. All biopsy reports that included a clinical description of papillary or verrucous architecture were retrieved. Read More

    Simultaneous Development of Three Different Neoplasms of Trichilemmoma, Desmoplastic Trichilemmoma and Basal Cell Carcinoma Arising from Nevus Sebaceus.
    Arch Craniofac Surg 2017 Mar 25;18(1):46-49. Epub 2017 Mar 25.
    Department of Pathology, Busan-Baik Hospital, Inje University School of Medicine, Busan, Korea.
    Nevus sebaceus is a hamartoma of the sebaceous gland that occurs congenitally, from which various secondary tumors can arise with a prevalence of 5%-6%. Benign neoplasms commonly arise from nevus sebaceous, but they have a very low malignant potential. Two neoplasms may occasionally arise within the same lesion, but it is rare for three or more neoplasms to occur in a nevus sebaceus simultaneously. Read More

    A case of reccuring giant condyloma of vulva in infant without sexual abuse successfully treated with electrocoagulation in Benin.
    Pan Afr Med J 2017 30;27:159. Epub 2017 Jun 30.
    Dermatology-Venereology, Faculty of Health, Cotonou, University of Abomey-Calavi, R. Benin.
    We report here a case of giant vulval condyloma in a two-year-old infant infected by her "baby sitter" without sexual abuse. Treated by surgical excision coupled with electrocoagulation, it was noted a rapid recurrence two weeks after treatment requiring a second electrocoagulation session. More than a year later, no lesion was noted, thus demonstrating therapeutic success. Read More

    Epidemiology and survival outcomes of sinonasal verrucous carcinoma in the United States.
    Laryngoscope 2018 Mar 2;128(3):651-656. Epub 2017 Sep 2.
    Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California, U.S.A.
    Introduction: Verrucous carcinoma (VC) is a rare, variant of squamous cell carcinoma with benign cytohistopathologic features and a generally favorable prognosis. Epidemiologic and clinical outcomes data are lacking as a result of limited cases of sinonasal VC.

    Objective: To describe the incidence and determinants of survival of patients with verrucous carcinoma of the sinonasal tract between the years of 1973 to 2014 using the Surveillance, Epidemiology, and End Results (SEER) database. Read More

    A population-based analysis of verrucous carcinoma of the oral cavity.
    Laryngoscope 2018 Feb 29;128(2):393-397. Epub 2017 Aug 29.
    Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA; the UCLA Head and Neck Cancer Program, Los Angeles, California, U.S.A.
    Objectives: To describe the incidence and determinants of survival of patients with verrucous carcinoma (VC) of the oral cavity between the years of 1973 and 2012 using the Surveillance, Epidemiology, and End Results (SEER) database.

    Study Design: Retrospective cohort study using a national database.

    Methods: The SEER registry was utilized to calculate survival trends for patients with VC of the oral cavity between 1973 and 2012. Read More

    CpG location and methylation level are crucial factors for the early detection of oral squamous cell carcinoma in brushing samples using bisulfite sequencing of a 13-gene panel.
    Clin Epigenetics 2017 15;9:85. Epub 2017 Aug 15.
    "M. Malpighi" Section of Anatomic Pathology, Department of Biomedical and Neuromotor Sciences, Bellaria Hospital, University of Bologna, via Altura n.3, 40137 Bologna, Italy.
    Background: Oral squamous cell carcinoma (OSCC) is usually diagnosed at an advanced stage and is commonly preceded by oral premalignant lesions. The mortality rates have remained unchanged (50% within 5 years after diagnosis), and it is related to tobacco smoking and alcohol intake. Novel molecular markers for early diagnosis are urgently needed. Read More

    Acquired epidermodysplasia verruciformis occurring in a renal transplant recipient.
    Cutis 2017 May;99(5):E9-E12
    Department of Dermatology, Geisinger Medical Center, Danville, Pennsylvania, USA.
    Acquired epidermodysplasia verruciformis (EDV) is a rare condition occurring in patients with depressed cellular immunity, particularly individuals with human immunodeficiency virus (HIV). Acquired EDV is less commonly reported in recipients of stem cell or solid organ transplantation. This condition typically manifests within 5 years of initial immunosuppression and can present as multiple hypopigmented to red, tinea versicolor-like macules or as multiple verrucous, flat-topped papules distributed over the trunk, arms, and legs. Read More

    Research on miRNA-195 and target gene CDK6 in oral verrucous carcinoma.
    Cancer Gene Ther 2017 Jul 16;24(7):282-288. Epub 2017 Jun 16.
    Department of oral and maxillofacial surgery, Central South University &Xiangya Stomatology Hospital, Changsha, Hunan Province, China.
    Oral verrucous carcinoma (OVC) is a verrucous variant of oral cavity squamous carcinoma (OSCC). The expression of miRNA from OVC and OSCC including their matched normal oral mucosa tissues was profiled through the Affymetrix GeneChip miRNA Arrays. TargetScan and miRanda databases were used to predict the target gene of miRNA-195. Read More

    Human Papilloma Virus-Associated Lips Verrucous Carcinoma in HIV-Infected Male.
    J Int Assoc Provid AIDS Care 2017 Jul/Aug;16(4):324-326. Epub 2017 Jun 1.
    3 Department of Dermatology, "Santa Maria della Misericordia" Hospital, University of Perugia, Perugia, Italy.
    Human papillomavirus (HPV) infection, widely known as the necessary cause of cervical cancer, has been established as a major etiologic factor for head and neck cancer (HNC). HIV-infected individuals are at higher risk of HPV-associated cancers than the general population. We describe a 45-year-old man with HIV and HPV coinfection, who presented progressively enlarging verrucous neoformations of the lips. Read More

    Dermoscopic Analysis of Nevus Sebaceus of Jadassohn: A Study of 13 Cases.
    Skin Appendage Disord 2017 May 16;3(2):83-91. Epub 2017 Mar 16.
    Department of Dermatology, University Hospital Hassan II, Fez, Morocco.
    Background: Nevus sebaceus of Jadassohn (NSJ) is a complex cutaneous hamartoma with various clinical appearances.

    Aim: To describe different dermoscopic patterns of this nevus according to its evolutionary stages.

    Methods: This was an analytical study of NSJ carried out in the Department of Dermatology at the University Hospital Hassan II, Fez, Morocco. Read More

    Comorbidity between HTLV-1-associated adult T-cell lymphoma/leukemia and verrucous carcinoma: a case report.
    Colomb Med (Cali) 2017 Mar 30;48(1):35-38. Epub 2017 Mar 30.
    Escuela de Medicina Facultad de Salud, Universidad del Valle Cali, Colombia.
    Background: Adult T-cell Leukemia/Lymphoma (ATLL) is classified as a peripheral CD4+ T-cell neoplasm caused by the human T-cell lymphotropic virus type 1 (HTLV-1). Typical symptoms are associated with leukemic infiltration; however, atypical and exaggerated manifestations of verrucous carcinoma have also been described.

    Case Report: We present here the case of a patient with multiple skin lesions, ischemic necrosis in the hallux and lymphadenopathies. Read More

    Verrucous carcinoma of the vulva: diagnosis and treatment.
    An Bras Dermatol 2017 Mar-Apr;92(2):243-245
    Dermatology Clinic at Irmandade da Santa Casa de Misericórdia de São Paulo - São Paulo (SP), Brazil.
    Vulvar cancer accounts for less than 1% of malignancies in women. Verrucous carcinoma of the vulva is a rare histological variation, comprising less than 1% of vulvar cancer cases. Although it is characterized as being locally invasive, the condition is not associated with metastatic spreading. Read More

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