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Biol Trace Elem Res 2019 Feb 15. Epub 2019 Feb 15.

Emergency Department of Shenzhen University General Hospital, Shenzhen, China.

Copper (Cu) and zinc (Zn) are involved in inflammatory process. This study was to investigate the clinical significance of Cu and Zn homeostasis alterations in acute appendicitis (AA). One hundred twenty-two AA patients and 102 healthy controls were enrolled in this study. Read More

Int J Surg 2019 Feb 12. Epub 2019 Feb 12.

Gastrounit - Surgical Division, Center for Surgical Research, Copenhagen University Hospital Hvidovre, Denmark; Institute of Clinical Medicine, University of Copenhagen, Denmark.

Background: In cases with clinically suspected appendicitis, there is controversy regarding the decision to remove a macroscopically normal appearing appendix during laparoscopy when no other intra-abdominal pathology is found. The aim of this study was to examine the rate of appendicitis, along with readmission and reoperation rates following diagnostic laparoscopy of clinically suspected appendicitis in patients where the appendix was not removed.

Methods: We performed a retrospective cohort analysis of patients who underwent a diagnostic laparoscopy due to clinical suspicion of appendicitis where no other pathology was found and the appendix was not removed. Read More

Contemp Clin Trials Commun 2019 Jun 30;14:100327. Epub 2019 Jan 30.

Louisiana State University Health Sciences Center, New Orleans, 2020 Gravier Street, New Orleans, LA, 70112, USA.

An extension of the isotonic regression based phase I clinical trial design is presented that incorporates partial follow-up times into estimation of the raw toxicity probabilities. This phase I clinical trial design, called the TITE-IR design, drastically decreases average trial duration by allowing patients to be treated immediately after being enrolled in a phase I clinical trial. The TITE-IR design does not require specification of a prior skeleton of toxicity probabilities like the continual reassessment method, has an additional trial parameter for controlling aggressiveness of dose escalation, and has an easily understood formula for estimating toxicity probabilities. Read More

Mod Pathol 2019 Feb 14. Epub 2019 Feb 14.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

Appendix pathology represents uncommonly encountered specimens with unique diagnostic challenges. To delineate common knowledge gaps, extramural consults submitted to seven institutions between 2016-2017 were reviewed. All appendix consults were resections (100%, n = 43), and the majority were directed for consultation by the originating pathologist (95%, n = 41) with no additional studies performed by the consultant (65%, n = 28). Read More

J Clin Med 2019 Feb 5;8(2). Epub 2019 Feb 5.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

The association between sleep apnea (SA) and peripheral artery disease (PAD) remains debatable, and there is no clinical tool to predict incident PAD in SA patients. The CHADS₂ score has been found useful in predicting PAD risk. This study was designed to investigate the association between these diseases and the usefulness of CHADS₂ and CHA₂DS₂ASc scores in predicting subsequent PAD in SA patients. Read More

BJU Int 2019 Feb 14. Epub 2019 Feb 14.

Department of Urology, University of Minnesota, Minneapolis, USA.

Objectives: Androgen deprivation therapy (ADT) has historically been the main management option for men with metastatic, hormone-sensitive prostate cancer. Over the last two decades, a number of agents have demonstrated a benefit in castration-resistant disease[1] and there has been interest to employ these drugs earlier in the disease course when the cancer is hormone-sensitive. Taxane-based chemotherapy has been utilized in such a manner and we aimed to assess the effects of early taxane-based chemohormonal therapy for newly diagnosed, metastatic, hormone-sensitive prostate cancer. Read More

Appl Immunohistochem Mol Morphol 2019 Feb 11. Epub 2019 Feb 11.

Departments of Pathology and Radiology, Hôpital Saint-Antoine AP-HP, Paris, France.

Am Surg 2019 Jan;85(1):82-85

Intraoperative consultations are an important component of acute care surgery (ACS). The nature of these consultations is incompletely characterized by the existing literature. The study objective was to define the characteristics of intraoperative consults managed by a mature ACS program at a Level I trauma center. Read More

Mymensingh Med J 2019 Jan;28(1):54-59

Dr Sharmin Akter Sumi, M Phil Student Thesis Part Complete, Department of Anatomy, Mymensingh Medical College (MMC), Mymensingh, Bangladesh.

This cross sectional descriptive study was performed on 70 postmortem vermiform appendices (male 34 and female 36) to find out the various positions of vermiform appendix of Bangladeshi people. The specimens were collected from autopsy laboratory of the Department of Forensic Medicine, Mymensingh Medical College, Mymensingh, Bangladesh by purposive sampling technique from October 2016 to March 2017. The collected samples were divided into four age groups. Read More

Am Surg 2018 Oct;84(10):1575-1579

Loma Linda University Cancer Center, Loma Linda, California, USA.

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC), although considered an acceptable treatment option in the management of selected patients with colon and appendiceal peritoneal carcinomatosis (PC), concerns about morbidity have limited its acceptance. Our objective was to evaluate the short- and long-term outcomes of CRS/HIPEC for appendix and colon PC performed at our institution and to elucidate factors predictive of patient outcomes. All patients who underwent CRS/HIPEC for appendix or colon PC from 2011 to 2017 were identified from our institution's prospective database. Read More

Am Surg 2018 Nov;84(11):e490-e491

Radiology 2019 Feb 12:181959. Epub 2019 Feb 12.

From the Departments of Medical Imaging (R.M., S.M.D., F.M., D.G., S.V., B.K., D.R.M., U.K.U.), Pediatrics (G.G.), and Pediatric Emergency Medicine (A.L.), University of Arizona College of Medicine, 1501 N Campbell Ave, Tucson, AZ 85724.

Background Advances in abdominal MRI have enabled rapid, free-breathing imaging without the need for intravenous or oral contrast material. The use of MRI as the primary imaging modality for suspected appendicitis has not been previously studied. Purpose To determine the diagnostic performance of MRI as the initial imaging modality in children suspected of having acute appendicitis. Read More

Acta Chir Belg 2019 Feb 12:1-8. Epub 2019 Feb 12.

a 2nd Department of General Surgery , Jagiellonian University Medical College , Kraków , Poland.

Background: In general, the three main options for stump closure in laparoscopic appendectomy are clips, endoscopic staplers and endoloops. However, there is no gold standard, especially regarding complicated acute appendicitis which is generally associated with worse outcomes.

Objectives: We aimed to assess the outcomes of different stump closure techniques during laparoscopic appendectomies for complicated appendicitis Methods: Our multicenter observational study of 18 surgical units assessed the outcomes of 1269 laparoscopic appendectomies for complicated appendicitis that used the three main stump closure techniques: clips, staplers and endoloops. Read More

Ann Thorac Med 2019 Jan-Mar;14(1):3-48

Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates.

This is the fourth version of the updated guidelines for the diagnosis and management of asthma, developed by the Saudi Initiative for Asthma (SINA) group, a subsidiary of the Saudi Thoracic Society. The main objective of the SINA is to have guidelines that are up to date, simple to understand, and easy to use by healthcare workers dealing with asthma patients. To facilitate achieving the goals of asthma management, the SINA panel approach is mainly based on the assessment of symptom control and risk for both adults and children. Read More

Ulus Travma Acil Cerrahi Derg 2019 Jan;25(1):34-38

Department of General Surgery, Dokuz Eylül University Faculty of Medicine, İzmir-Turkey.

Background: Stump closure is the most important part of a laparoscopic appendectomy (LA). Closing the appendix base with knot tying is the most cost-effective method. The defined risk factor for surgical site infection (SSI) after LA is the contamination of trocar entry area by inflamed appendicitis. Read More

Otol Neurotol 2019 Mar;40(3):276-283

Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, New York.

Objective: This study explores the current literature regarding associations between phosphodiesterase-5 (PDE-5) inhibitors and ototoxicity and provides a detailed summary and discussion of the findings.

Data Sources: A comprehensive electronic search of PubMed/MEDLINE, Scopus, and Cochrane Library for studies published from database inception through March 21, 2018.

Study Selection: Basic science articles, epidemiological studies, randomized controlled trials, cohort studies, case reports, reviews, meta-analyses, press releases, and newsletters were included. Read More

Trauma Surg Acute Care Open 2019 24;4(1):e000243. Epub 2019 Jan 24.

Division of General Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

A 57-year-old woman with morbid obesity (body mass index [BMI] of 43), systemic lupus on steroids, type 2 insulin-dependent diabetes, peripheral vascular disease, unprovoked pulmonary embolism on rivaroxaban, and hypertension presented with 3 days of worsening abdominal pain and nausea. She had an extensive surgical history including a cesarean section, multiple laparotomies for small bowel obstructions (one complicated by bowel perforation requiring resection), and a double-barrelled ileostomy, which had been since reversed. As a result, she had a massive incisional hernia (figure 1). Read More

Eur J Prev Cardiol 2019 Feb 10:2047487318825350. Epub 2019 Feb 10.

1 European Society of Cardiology, Sophia Antipolis, France.

Aims: The aim of this study was to determine whether the Joint European Societies guidelines on secondary cardiovascular prevention are followed in everyday practice.

Design: A cross-sectional ESC-EORP survey (EUROASPIRE V) at 131 centres in 81 regions in 27 countries.

Methods: Patients (<80 years old) with verified coronary artery events or interventions were interviewed and examined ≥6 months later. Read More

Niger J Clin Pract 2019 Feb;22(2):270-275

Department of Pathology, Erzincan University, Faculty of Medicine, Erzincan, Turkey.

Background: Parasitic infestation of the appendix is uncommon. Parasitic infections can cause inflammation in the appendix and can imitate acute appendicitis clinically. Enterobius vermicularis and Taenia species are among the most common parasitic agents causing acute appendicitis. Read More

Ann Afr Med 2019 Jan-Mar;18(1):36-41

Department of Surgery, Faculty of Clinical Sciences, College of Medicine, General Surgery Unit, University of Lagos, Idi-Araba, Lagos, Nigeria.

Background: Acute perforation of the appendix is one of the complications of appendicitis that is associated with increased morbidity and mortality and hence regarded as a surgical emergency. Risk factors for perforated appencidicits include extremes of age, male sex, pregnancy, immunosuppression, comorbid medical conditions and previous abdominal surgery.

Objectives: This study focuses on the pattern of presentation, risk factors, morbidity and mortality of patients managed for perforated appendicitis in our centre. Read More

BMJ 2019 Feb 6;364:l294. Epub 2019 Feb 6.

Department of Orthopaedic Surgery and Traumatology, Joint Research, OLVG, Amsterdam, The Netherlands

Clinical Question: Do adults with atraumatic shoulder pain for more than 3 months diagnosed as subacromial pain syndrome (SAPS), also labelled as rotator cuff disease, benefit from subacromial decompression surgery? This guideline builds on to two recent high quality trials of shoulder surgery.

Current Practice: SAPS is the common diagnosis for shoulder pain with several first line treatment options, including analgesia, exercises, and injections. Surgeons frequently perform arthroscopic subacromial decompression for prolonged symptoms, with guidelines providing conflicting recommendations. Read More

J Laparoendosc Adv Surg Tech A 2019 Feb 5. Epub 2019 Feb 5.

2 Division of Pediatric Surgery, Children's National Health System, Washington, District of Columbia.

Enterobius vermicularis associated appendiceal colic and acute appendicitis are rarely encountered in the United States. The 9-year-old patient described in this case presented with right lower quadrant abdominal pain, nausea, and vomiting consistent with acute appendicitis and was brought to the operating room for an appendectomy. Intraoperatively a pinworm, E. Read More

Ned Tijdschr Geneeskd 2019 Jan 25;163. Epub 2019 Jan 25.

Rode Kruis Ziekenhuis, afd. Chirurgie, Beverwijk.

A 19-year old woman with acute pain in the lower right quadrant of the abdomen was seen in the emergency room. Because we suspected an anomaly of the appendix, we performed a laparoscopy. We unexpectedly found a torsion of a Hydatid of Morgagni, a stalked cyst of the fallopian tube. Read More

Front Pediatr 2019 21;7. Epub 2019 Jan 21.

Consultant Paediatric Urologist, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom.

To report the current status of Robotic approach to creation of Catheterisable channel (CC) with the author's personal experience compared to published literature on technical steps, follow up, and outcomes. CC data was extracted from the prospective database set up for all Robotic pediatric urology procedures performed by the author at his institution. A literature search was then performed to look at the evidence base. Read More

Int J Cardiol 2019 Jan 10. Epub 2019 Jan 10.

Servicio de Cardiología, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain.

Aim: To evaluate the effect of the type of surgical indication on mortality in infective endocarditis (IE) patients who are rejected for surgery.

Methods And Results: From January 2008 to December 2016, 2714 patients with definite left-sided IE were attended in the participating hospitals. One thousand six hundred and fifty-three patients (60. Read More

Surg Obes Relat Dis 2019 Jan 11. Epub 2019 Jan 11.

Department of Surgery, Queen's University, Kingston, Ontario, Canada. Electronic address:

Background: An incidental finding of intestinal nonrotation at the time of bariatric surgery poses the following 2 dilemmas: (1) which operation to perform, and (2) whether an appendectomy should be performed concurrently.

Objectives: To review the experience of 2 Bariatric Centers of Excellence with laparoscopic sleeve gastrectomy (LSG) in patients with intestinal nonrotation, and to perform a systematic review of the literature on this topic.

Setting: Two Bariatric Centers of Excellence as designated by the Ontario Bariatric Network. Read More

BMC Surg 2019 Feb 4;19(1):17. Epub 2019 Feb 4.

Department of Hepatobiliary Surgery, the Second Affiliated Hospital, Nanchang University, No. 1, mingde road, Nanchang, Jiang xi, China.

Background: Hepatic portal vein gas (HPVG) is a rare acute abdomen, which is not an independent disease. Meanwhile, HPVG combined with appendicitis has been rarely reported. We found only a similar report by looking for literature, but no intestinal necrosis occurred. Read More

Int J Mol Sci 2019 Feb 3;20(3). Epub 2019 Feb 3.

NASA Ames Research Center, Space Biosciences Division, Moffett Field, CA 94035, USA.

Space radiation has recently been considered a risk factor for astronauts' cardiac health. As an example, for the case of how to query and identify datasets within NASA's GeneLab database and demonstrate the database utility, we used an unbiased systems biology method for identifying key genes/drivers for the contribution of space radiation on the cardiovascular system. This knowledge can contribute to designing appropriate experiments targeting these specific pathways. Read More

Int J Surg Case Rep 2019 Jan 29;55:103-106. Epub 2019 Jan 29.

Department of Gastroenterological Surgery, Hiroshima City Asa Citizens Hospital, Japan.

Introduction: Perforating appendicitis and abscess-forming appendicitis may cause septic disseminated intravascular coagulation (DIC). However, non-perforating acute appendicitis with septic DIC is extremely rare.

Presentation Of Case: A 67-year-old man was referred to our hospital one day after starting oral antibiotic treatment for acute appendicitis. Read More

Pediatr Surg Int 2019 Feb 2. Epub 2019 Feb 2.

Department of Paediatric Surgery, Women's and Children's Hospital, 72 King William Street, North Adelaide, South Australia, 5006, Australia.

BMJ Case Rep 2019 Feb 1;12(2). Epub 2019 Feb 1.

Griffith University School of Medicine, Gold Coast, Queensland, Australia.

A 17-year-old man presented to the emergency department 10 days postlaparoscopic appendicectomy with ongoing lower abdominal pain. The pain was associated with fevers, chills, sweating and constipation. There were no other associated symptoms. Read More

World J Clin Cases 2019 Jan;7(2):209-214

Department of Pathology, E-Da Cancer Hospital, I-Shou University, Kaohsiung City 82445, Taiwan.

Background: Colonic lipomas are rare, slow-growing benign tumors. Colonic lipomas are generally asymptomatic and are found incidentally. Although cases of cecal lipoma have been sporadically reported in the literature, the disease has not been systematically reviewed. Read More

World J Gastrointest Surg 2019 Jan;11(1):19-26

Department of Surgery and Liver Transplant Institute, Inonu University Faculty of Medicine, Malatya 44280, Turkey.

Background: Incidental appendectomy can be defined as the removal of a clinically normal appendix during another surgical procedure unrelated to appendicitis or other appendicular diseases.

Aim: To compare the demographic, biochemical, and histopathological features of the patients who underwent incidental and standard appendectomy.

Methods: The demographic, biochemical, and histopathological data of 72 patients (Incidental App group) who underwent incidental appendectomy during living donor hepatectomy at our Liver Transplant Center between June 2009 and December 2016 were compared with data of 288 patients (Acute App group) who underwent appendectomy for presumed acute appendicitis. Read More

Am J Surg 2018 Dec 31. Epub 2018 Dec 31.

Department of Surgery, St George Hospital, New South Wales, University of New South Wales, Australia. Electronic address:

Background: This study examines the impact of intraoperative macroscopic tumour consistency on short-term and long-term outcomes after cytoreductive surgery (CRS) with intraperitoneal chemotherapy (IPC) for appendiceal adenocarcinoma with peritoneal metastases.

Methods: Macroscopic intraoperative tumour consistency was classified in three groups as soft (jelly-like geltatinous tumours), hard (hard tumour nodules without gelatinous features) and intermediate (both soft and hard features). In-hospital mortality, major morbidity, intensive care unit (ICU), high dependency unit (HDU) and total hospital stay, disease-free survival (DFS) and overall survival (OS) were compared. Read More

Medicine (Baltimore) 2019 Feb;98(5):e14104

Department of Surgery, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, South Korea.

Rationale: The horseshoe anomaly of the vermiform appendix is extremely rare. Preoperative confirmation of this anomaly is difficult; therefore, routine procedures, such as appendectomy, may become unexpectedly challenging when such anomalies are encountered during the surgical process.

Patient Concerns: A 33-year-old man presented with abdominal pain in the right lower abdomen owing to acute appendicitis confirmed via computed tomography. Read More

Int J Colorectal Dis 2019 Jan 30. Epub 2019 Jan 30.

Department of Colorectal Surgery, Digestive Diseases and Surgery Institute, Cleveland Clinic Foundation, Cleveland, OH, 44195, USA.

Purpose: Data on the management of appendix orifice lesions are limited. We present our experience on the management of appendix orifice lesions focusing on the range of size, histology, treatment, and outcomes for polyps at the appendix orifice.

Methods: Retrospective descriptive study at a tertiary referral center. Read More

J Cell Mol Med 2019 Jan 29. Epub 2019 Jan 29.

Provincial Clinical Medicine College of Fujian Medical University, Fuzhou, PR China.

Objective: This study aimed to investigate the effects of transforming growth factor β1 (TGF β1) and hepatocyte growth factor (HGF) on the expression of connective tissue growth factor (CTGF) in human atrial fibroblasts, and to explore the relationship of these factors in atrial fibrosis and atrial anatomical remodelling (AAR) of patients with atrial fibrillation (AF).

Methods: Fresh right auricular appendix tissue of 20 patients with rheumatic heart disease undergoing valve replacement surgery was collected during surgeries, 10 patients had sinus rhythm(SR), and 10 patients had chronic atrial fibrillation (CAF). Atrial fibroblasts were then cultured from the tissues with differential attachment technique and treated with either TGFβ1 (10 ng/mL) or HGF (100 ng/mL). Read More

J Surg Case Rep 2019 Jan 24;2019(1):rjy367. Epub 2019 Jan 24.

Department of General Surgery, Cantonal Hospital of Lucerne, Spitalstrasse, 6000 Lucerne 16, Switzerland.

Although the most common localization of extranodal non-Hodgkin lymphoma is the gastrointestinal system, the infiltration of the vermiform appendix is a very rare condition. We report a case of mantle cell lymphoma affecting the appendix as an incidental finding due to gynecological surgery. A 57-year-old woman presented with increasing pain in the right lower abdomen since months. Read More

Can J Surg 2019 Feb;62(1):33-38

From the Department of Surgery, University of Alberta, Edmonton, Alta. (Saravana-Bawan, Warkentin, Churchill, Khadaroo); the Division of Geriatrics, Department of Medicine, University of Alberta, Edmonton, Alta. (Rucker, Carr); and the Department of Critical Care Medicine, University of Alberta, Edmonton, Alta. (Khadaroo).

Background: Among older inpatients, the highest incidence of delirium is within the surgical population. Limited data are available regarding postoperative delirium risk in the acute care surgical population. The purpose of our study was to establish the incidence of and risk factors for delirium in an older acute care surgery population. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):2482-2484

Dept. of Surgery, Sensoji Hospital.

A 70-year-old man with lower right quadrant abdominal discomfort was admitted to our hospital. Colonoscopy identified a villous tumor protruding into the cecal lumen from the appendiceal orifice. Abdominal computed tomography(CT)revealed a cecal tumor with a swollen appendix. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):2458-2460

Dept. of Surgical Oncology, Osaka City University Graduate School of Medicine.

A 73-year-old woman presented to her doctor because of lower abdominal pain and distension. A neoplastic lesion in the lower abdomen was revealed, and she was referred to our department. Enhanced CT showed wall thickening in the urinary bladder and a 6 cm mass that extended to the appendix. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):1848-1850

Dept. of Surgery, Sumitomo Hospital.

A 40-year-old woman was admitted to our hospital with the chief complaint of miction pain. MRI showed fundal wall thickening of the bladder in contact with the appendix. Under cystoscopy, redness of the mucous membrane was found in the posterior wall of the bladder. Read More

Sensors (Basel) 2019 Jan 27;19(3). Epub 2019 Jan 27.

Institute of Metrology and Biomedical Engineering, Faculty of Mechatronics, Warsaw University of Technology, ul. Sw. Andrzeja Boboli 8, 02-525 Warszawa, Poland.

In the article a differential equation describing transient behavior of variable area (VA) meters has been developed and validated experimentally for air as a measured fluid and for two float shapes-plumb bob and sphere. A modified version of simplex algorithm adapted for nonlinear constraint optimization problems was applied to minimize the settling time of VA meters in two cases. In the first case both the float and tube geometry were altered. Read More

Korean J Gastroenterol 2019 Jan;73(1):45-49

Division of Gastroenterology, Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Korea.

A 49-year-old man visited the emergency room of Korea University Ansan Hospital with hematochezia starting the day before the visit. Recently, he was on anti-platelet medication due to hypertension. The patient had no definite symptoms other than hematochezia. Read More

Case Rep Urol 2018 26;2018:1284756. Epub 2018 Nov 26.

Department of Pediatric Urology, Jichi Medical University, Children's Medical Center, Tochigi, Japan.

A 9-year-old girl was diagnosed with primary alveolar soft part sarcoma of the bladder after imaging examinations and transurethral resection (TUR) of the bladder tumor. As a positive surgical margin of the TUR indicated residual tumor cells, we performed a cystourethrectomy to remove the tumor. A continent urinary reservoir for self-catheterization was constructed using the Mainz pouch technique, and an abdominal (umbilical) continent catheterizable stoma using the appendix was performed. Read More

Case Rep Gastroenterol 2018 Sep-Dec;12(3):765-772. Epub 2018 Dec 20.

Department of Pathology, Dokkyo Medical University Saitama Medical Center, Koshigaya, Japan.

Pulse granuloma is a rare pathologic condition considered to be a benign inflammatory reaction to foreign materials originated from ingested legume matter. As for pulse granulomas of the gastrointestinal tract, association with diverticular diseases is relatively common, but only a few pulse granuloma cases associated with appendicitis have been reported. This report presents histopathologic findings of pulse granuloma lesions observed in two appendectomy cases, with some histochemical examinations of cellulose matter which is reportedly a major component to provoke pulse granuloma reaction. Read More

J Indian Assoc Pediatr Surg 2019 Jan-Mar;24(1):65-67

Department of Pediatric Surgery, Maulana Azad Medical College, New Delhi, India.

We describe the case of a bladder exstrophy-epispadias complex (BEEC), in which a "split" appendix was used simultaneously as a posterior urethral replacement (for strictured Mitchell's repair) as well as a Mitrofanoff channel. Split appendix had been used before for simultaneous Mitrofanoff and Malone's antegrade contrast enema channels to manage neurogenic bladder and bowel. To the best of our knowledge, this is the first reported case for the use of split appendix for urethral reconstruction in a child with BEEC. Read More

Gynecol Obstet Fertil Senol 2019 Jan 24. Epub 2019 Jan 24.

Clinique de gynécologie, hôpital Jeanne-de-Flandre, centre hospitalier régional universitaire de Lille, 1, rue Eugène-Avinée, 59000 Lille, France.

Early stage ovarian epithelial cancer (stage I according to the FIGO classification, i.e. limited to ovaries) affects 20% to 33% of patients with ovarian cancer. Read More

Bratisl Lek Listy 2018 ;119(12):743-746

Objectives: Visualization of unexpected distribution of myenteric ganglia in normal human appendiceal wall by immunofluorescence.

Background: The myenteric plexus is located between the longitudinal and circular muscle layers of the GIT. However, recently the irregular distribution of myenteric ganglia was revealed in human appendix. Read More

J Pediatr Surg 2018 Dec 28. Epub 2018 Dec 28.

Department of Surgery, Zucker School of Medicine at Hofstra Northwell, Cohen Children's Medical Center, 269-1 76th Ave, Queens, NY 11040, United States.

Introduction: Negative appendectomy rate (NAR) is a quality metric used in the surgical management of appendicitis. The rates of negative appendectomy (NA) in children range anywhere from 1% to 40% in the literature. Many reports do not provide clear pathological definitions for either appendicitis or NA on which they base their calculation of NAR. Read More