21,593 results match your criteria Ventricular Septal Defect


Post-Left Atrium Space Index in Fetuses With Total Anomalous Pulmonary Venous Connection and Other Congenital Heart Diseases.

J Ultrasound Med 2020 Jun 3. Epub 2020 Jun 3.

Department of Ultrasound, Beijing Anzhen Hospital, Capital Medical University, Beijing Key Laboratory of Maternal-Fetal Medicine in Fetal Heart Disease, Beijing, China.

Objectives: We aimed to explore the value of the post-left atrium space (PLAS) index in the diagnosis of total anomalous pulmonary venous connection (TAPVC) and the effect of other congenital heart diseases on the PLAS index in the fetus.

Methods: The PLAS index of 69 fetuses with TAPVC was analyzed retrospectively. Approximately 252 healthy fetuses were randomly selected as controls, and 110 cases of intracardiac malformations were randomly selected for comparison. Read More

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http://dx.doi.org/10.1002/jum.15362DOI Listing

The Prevalence of Congenital Heart Diseases in Syndromic Children at King Khalid National Guard Hospital from 2005 to 2016.

Cureus 2020 Apr 29;12(4):e7891. Epub 2020 Apr 29.

Pediatric Cardiology, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, SAU.

Background Congenital heart diseases (CHDs) are abnormalities that present in the heart since birth and are one of the leading causes of infant mortality in the world. CHDs are more common among children with dysmorphic syndromes. The current study aims to estimate the prevalence of many CHDs in different dysmorphic syndromes. Read More

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http://dx.doi.org/10.7759/cureus.7891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255536PMC

The ventilatory abnormalities and prognostic values of H FPEF score in dyspnoeic patients with preserved left ventricle systolic function.

ESC Heart Fail 2020 Jun 3. Epub 2020 Jun 3.

Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

Aims: Heart failure with preserved ejection fraction (HFpEF) is one of the major diagnoses in dyspnoeic subjects, and H FPEF score enables robust differentiation of HFpEF. Given ventilatory abnormalities prevail in subjects with HFpEF, the associations between H FPEF score and pulmonary function remain to be elucidated.

Methods And Results: Subjects who presented with exertional dyspnoea and had left ventricular ejection fraction of >50% were eligible for this study. Read More

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http://dx.doi.org/10.1002/ehf2.12754DOI Listing

Acquired Double-Chamber Right Ventricle in an Adult Due to an Aorto-Right Ventricular Fistula.

J Cardiothorac Vasc Anesth 2020 May 16. Epub 2020 May 16.

Department of Cardiothoracic Surgery, National Heart Center, Royal Hospital, Muscat, Oman.

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http://dx.doi.org/10.1053/j.jvca.2020.04.007DOI Listing

Twenty Years of Repair of Ventricular Septal Defects in Ghana.

West Afr J Med 2020 Jul-Aug;37(3):281-283

National Cardiothoracic Centre, Korle-Bu Teaching Hospital, P. O. Box KB 846, Korle-Bu, Accra, Ghana.

Background: Ventricular Septal Defect (VSD) is the commonest congenital heart disease. Without appropriate treatment, it is associated with significant morbidity and mortality. Surgical repair under cardiopulmonary bypass has been the standard treatment. Read More

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Hemodynamics of an Iatrogenic Atrial Septal Defect (IASD) after MitraClip Implantation.

Eur J Clin Invest 2020 May 31:e13295. Epub 2020 May 31.

Innere Medizin III, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel, Germany.

Background: The MitraClip procedure requires transseptal access of the left atrium with a 24 F guiding sheath. We evaluated invasively whether a MitraClip induced iatrogenic atrial septal defect (IASD) leads to development of a relevant interatrial shunt and right ventricular overload.

Methods: A total of 69 patients who underwent a MitraClip procedure due to a severe mitral valve regurgitation (MVR) were included in the observational, retrospective cohort study. Read More

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http://dx.doi.org/10.1111/eci.13295DOI Listing

Creating the BELgian COngenital heart disease database combining administrative and clinical data (BELCODAC): Rationale, design and methodology.

Int J Cardiol 2020 May 27. Epub 2020 May 27.

KU Leuven Department of Public Health and Primary Care, Academic Center for Nursing and Midwifery, KU Leuven - University of Leuven, Leuven, Belgium; Institute of Health and Care Sciences, University of Gothenburg, Gothenburg, Sweden; Department of Pediatrics and Child Health, University of Cape Town, Cape Town, South Africa. Electronic address:

Background: Congenital heart disease (CHD) entails a broad spectrum of malformations with various degrees of severity and prognosis. Consequently, new and specific healthcare needs are emerging, requiring responsive healthcare provision. Research on this matter is predominantly performed on population-based databases, to inform clinicians, researchers and policy-makers on health outcomes and economic burden of CHD. Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.05.059DOI Listing

Hybrid approach to postmyocardial infarction ventricular septal defect repair.

Catheter Cardiovasc Interv 2020 May 30. Epub 2020 May 30.

Department of Medicine/Cardiology, NorthShore University HealthSystem, Evanston, Illinois, USA.

Postinfarction ventricular septal rupture is a rare and devastating complication of myocardial infarction. Despite attempts at acute surgical and percutaneous defect closure, morbidity and mortality remain high. Herein, we describe a hybrid surgical and catheter-based approach to defect closure in a 63-year-old woman with postinfarction ventricular septal rupture and cardiogenic shock. Read More

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http://dx.doi.org/10.1002/ccd.29000DOI Listing

MicroRNA-375 overexpression disrupts cardiac development of Zebrafish (Danio rerio) by targeting notch2.

Protoplasma 2020 May 28. Epub 2020 May 28.

Department of Child Health Care, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, 123rd Tianfei Street, Mochou Road, Nanjing, 210004, China.

MicroRNAs are small noncoding RNAs that are important for proper cardiac development. In our previous study of fetuses with ventricular septal defects, we discovered that microRNA-375 (miR-375) is obviously upregulated compared with that in healthy controls. Our study also confirmed that miR-375 is crucial for cardiomyocyte differentiation. Read More

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http://dx.doi.org/10.1007/s00709-020-01490-4DOI Listing

The Effect of Perioperative Administration of Treprostinil in Infants with Non-restrictive Ventricular Septal Defect and Severe Pulmonary Arterial Hypertension.

Pediatr Cardiol 2020 May 28. Epub 2020 May 28.

Department of Cardiac Surgery, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, China.

This study investigated the efficacy and safety of intravenous treprostinil during the perioperative period in infants with non-restrictive ventricular septal defect (VSD) and severe pulmonary arterial hypertension (PAH) undergoing surgical VSD repair. This was a retrospective study. There were 79 infants with non-restrictive VSD and severe PAH receiving surgical treatment from January to December 2019 in our cardiac center. Read More

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http://dx.doi.org/10.1007/s00246-020-02387-yDOI Listing

Stabbed Through The Heart: An Unusual VSD Presentation.

JACC Case Rep 2020 Apr 15;2(4):559-564. Epub 2020 Apr 15.

Section of Cardiology, Department of Medicine, University of Chicago Medical Center, Chicago, IL.

Traumatic ventricular septal defects due to penetrating cardiac injury are uncommon. Transthoracic echocardiography is an essential tool in diagnosis. Options for closure include either surgical or percutaneous repair. Read More

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http://dx.doi.org/10.1016/j.jaccas.2019.12.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255421PMC

Management of Unoperated Tetralogy of Fallot in a 59-Year-Old Patient.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620926908

Riverside University Health Systems, Moreno Valley, CA, USA.

Tetralogy of Fallot is the most common cyanotic congenital heart defect consisting of an overriding aorta, right ventricular outflow obstruction, ventricular septal defect, and right ventricular hypertrophy. Without surgical management, approximately only 3% of patients survive past the age of 40 years. Cases of unoperated patients reaching adulthood have been reported; however, few studies describe treatment guidelines for surgical or therapeutic management. Read More

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http://dx.doi.org/10.1177/2324709620926908DOI Listing

Repeated Transcatheter Closure of Postinfarction Ventricular Septal Defect.

J Cardiovasc Imaging 2020 May 27. Epub 2020 May 27.

Division of Cardiology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.

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http://dx.doi.org/10.4250/jcvi.2020.0015DOI Listing

Effect of transcatheter closure by Amplatzer Duct Occluder II in patients with small ventricular septal defect.

Cardiovasc Interv Ther 2020 May 27. Epub 2020 May 27.

Pediatric Cardiac Center, College of Medicine, Queen Sirikit National Institute of Child Health, Rangsit University, Bangkok, Thailand.

Transcatheter closure of ventricular septal defect (VSD) is an alternative treatment of surgery. However, because of the potential risk of the complete atrioventricular block (AVB) and the lack of available dedicated devices for VSD, this procedure rarely used most centers. Recently in Thailand, with distinct device design that may cause less clamp force and radial force, the AmplatzerDuct Occluder (ADO) II has become available for the closure of small VSDs. Read More

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http://dx.doi.org/10.1007/s12928-020-00677-zDOI Listing

Comparisons of perventricular device closure, conventional surgical repair, and transcatheter device closure in patients with perimembranous ventricular septal defects: a network meta-analysis.

BMC Surg 2020 May 26;20(1):115. Epub 2020 May 26.

Department of Cardiovascular Surgery, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan, 610041, P.R. China.

Background: Treatments for perimembranous ventricular septal defects (pmVSD) mainly include conventional surgical repair (CSR), transcatheter device closure (TDC), and perventricular device closure (PDC). We aimed to perform a network meta-analysis to compare the three approaches in patients with pmVSD.

Methods: We searched for comparative studies on device closure and conventional repair for pmVSD to April 2020. Read More

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http://dx.doi.org/10.1186/s12893-020-00777-wDOI Listing

Transforming Growth Factor Beta3 is Required for Cardiovascular Development.

J Cardiovasc Dev Dis 2020 May 24;7(2). Epub 2020 May 24.

Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29209, USA.

Transforming growth factor beta3 () gene mutations in patients of arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD1) and Loeys-Dietz syndrome-5 (LDS5)/Rienhoff syndrome are associated with cardiomyopathy, cardiac arrhythmia, cardiac fibrosis, cleft palate, aortic aneurysms, and valvular heart disease. Although the developing heart of embryos express , its overarching role remains unclear in cardiovascular development and disease. We used histological, immunohistochemical, and molecular analyses of fetuses and compared them to wildtype littermate controls. Read More

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http://dx.doi.org/10.3390/jcdd7020019DOI Listing

Intubation precautions in a pediatric patient with severe COVID-19.

J Pediatr Surg Case Rep 2020 Jul 18;58:101495. Epub 2020 May 18.

Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, USA.

We present the case of a child diagnosed with COVID-19 soon after open-heart surgery who required an urgent second surgery. The patient suffered from severe COVID-19 disease. The utility of preoperative COVID-19 testing, determination of recovery by an array of inflammatory markers and perioperative management are described. Read More

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http://dx.doi.org/10.1016/j.epsc.2020.101495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233244PMC

Tetralogy of Fallot With Pulmonary Atresia: Anatomy, Physiology, Imaging, and Perioperative Management.

Semin Cardiothorac Vasc Anesth 2020 May 26:1089253220920480. Epub 2020 May 26.

Seattle Children's Hospital, Seattle, WA, USA.

Tetralogy of Fallot (ToF) with pulmonary atresia (ToF-PA) is a complex congenital heart defect at the extreme end of the spectrum of ToF, with no antegrade flow into the pulmonary arteries. Patients differ with regard to the sources of pulmonary blood flow. In the milder spectrum of disease, there are confluent branch pulmonary arteries fed by ductus arteriosus. Read More

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http://dx.doi.org/10.1177/1089253220920480DOI Listing

Reassessment of the location of the conduction system in atrioventricular septal defect using phase-contrast computed tomography.

Semin Thorac Cardiovasc Surg 2020 May 22. Epub 2020 May 22.

Division of Biomedical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom.

The location of the atrioventricular conduction axis in the setting of atrioventricular septal defect has previously been shown by histology and intraoperative recordings. We have now re-assessed the arrangement using phase-contrast computed tomography, aiming to provide precise measurements so as to optimize future surgical repairs. We used the system based on an X-ray Talbot grating interferometer using the beamline BL20B2 in a SPring-8 synchrotron radiation facility available in Japan. Read More

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http://dx.doi.org/10.1053/j.semtcvs.2020.03.011DOI Listing

Percutaneous device closure of pediatirc patent ductus arteriosus through femoral artery guidance by transthoracic echocardiography without radiation and contrast agents.

J Cardiothorac Surg 2020 May 24;15(1):107. Epub 2020 May 24.

Department of Echocardiography, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.

Background: For many years, percutaneous interventional occlusion of congenital patent ductus arteriosus (PDA) has been completed using radiation and contrast agents. In this study, transthoracic echocardiography without radiation and contrast agents was used to complete percutaneous occlusion of pediatric PDA.

Methods: Thirty-two children (8 males and 24 females) with normal heart function and no other intracardiac deformities were diagnosed with PDA (20 funnel type; 12 tube type), One patient had peripheral facial paralysis, 1 patient had epilepsy, and 1 case had multiple cervical deformities. Read More

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http://dx.doi.org/10.1186/s13019-020-01119-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245820PMC

Ventricular septal defect jeopardizes the autograft in a Ross operation.

Ann Thorac Surg 2020 May 20. Epub 2020 May 20.

Department of Cardiac Surgery, Lens Hospital, Lens, France; Bois Bernard Private Hospital, Ramsay Générale de Santé, Bois Bernard, France.

The Ross operation is the gold standard for aortic valve replacement (AVR) in young patients as it is a durable and anticoagulation-free alternative to mechanical AVR. Careful assessment of the pulmonary valve is critical as it should become a durable neoaortic valve. Here we report the case of a patient in whom the pulmonary autograft was jeopardized by a large doubly committed ventricular septal defect (VSD), which did not offer sufficient autologous tissue for the proximal suture line. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.03.119DOI Listing

Oral batyl alcohol supplementation rescues decreased cardiac conduction in ether phospholipid-deficient mice.

J Inherit Metab Dis 2020 May 22. Epub 2020 May 22.

Department of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Vienna, Austria.

Plasmalogens (Pls) are a class of membrane phospholipids which serve a number of essential biological functions. Deficiency of Pls is associated with common disorders such as Alzheimer's disease or ischemic heart disease. A complete lack of Pls due to genetically determined defective biosynthesis gives rise to rhizomelic chondrodysplasia punctata (RCDP), characterized by a number of severe disabling pathologic features and death in early childhood. Read More

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http://dx.doi.org/10.1002/jimd.12264DOI Listing

Current practice in atrial septal defect occlusion in children and adults.

Expert Rev Cardiovasc Ther 2020 May 22:1-15. Epub 2020 May 22.

Sidra Heart Center, Sidra Medicine , Doha, Qatar.

Introduction: Atrial septal defect (ASD) is one of the most common congenital heart diseases (CHD) in children and adults. This group of malformations includes several types of atrial communications allowing shunting of blood between the systemic and the pulmonary circulations. Early diagnosis and treatment carries favorable outcomes. Read More

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http://dx.doi.org/10.1080/14779072.2020.1767595DOI Listing

Tetralogy of Fallot or Pulmonary Atresia with Ventricular Septal Defect after the Age of 40 Years: A Single Center Study.

J Clin Med 2020 May 19;9(5). Epub 2020 May 19.

Department of Congenital Heart Disease and Paediatric Cardiology, German Heart Centre Munich, Technical University of Munich, 80636 Munich, Germany.

Background The population of adults with tetralogy of Fallot (TOF) or pulmonary atresia with ventricular septal defect (PA/VSD) is growing and aging. Data regarding older patients are scarce. Prognostic outcome parameters in adults with TOF or PA/VSD ≥ 40 years were studied. Read More

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http://dx.doi.org/10.3390/jcm9051533DOI Listing

Transposition of the Great Arteries-Are We Doing Better? Correlating Outcome to Change in Renal Function Over 2 Decades of Arterial Switch Operation.

Pediatr Crit Care Med 2020 May 20. Epub 2020 May 20.

Pediatric Cardiac Intensive Care Unit, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.

Objectives: It is believed that management of neonates with dextro-transposition of the great arteries is constantly improving. Renal function may play a role in the prognosis of patients after congenital heart surgery. The aim of this study was to describe the outcome of neonates who underwent arterial switch operation during the past 2 decades using renal function as a surrogate marker for morbidity and mortality. Read More

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http://dx.doi.org/10.1097/PCC.0000000000002387DOI Listing

Shift From Left to a Right Bundle Block on ECG Leading to the Diagnosis of a Malpositioned Lead in the Coronary Sinus: A Case Report.

Am J Med Case Rep 2020 14;8(7):178-181. Epub 2020 Apr 14.

Division of Cardiovascular Diseases and Department of Internal Medicine, State University of New York, Downstate Medical Center, Brooklyn, NY 11203, U.S.A.

On electrocardiography (ECG), ventricular pacing appears as a spikes that precede induced QRS complexes. The induced complexes with a right ventricular lead have the morphology of a left bundle branch block (LBBB). We describe a case of malposition right ventricular (RV) lead in the coronary sinus diagnosed based on the changes noted in the ECG tracing. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237009PMC

Incidence and Patterns of Congenital Heart Disease Among Jordanian Infants, a Cohort Study From a University Tertiary Center.

Front Pediatr 2020 5;8:219. Epub 2020 May 5.

Department of Pediatrics and Neonatology, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.

Data is limited about the incidence of congenital heart disease in Jordan. The goal of this study is to determine the incidence and patterns of congenital heart diseases (CHD) among Jordanian infants evaluated at King Abdullah University Hospital. A retrospective chart review was conducted for all infants who had an echocardiogram evaluation in the 3-years period July 2016-June 2019. Read More

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http://dx.doi.org/10.3389/fped.2020.00219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214919PMC

Outcomes of infants and children undergoing surgical repair of ventricular septal defect: a review of the literature and implications for research with an emphasis on pulmonary artery hypertension.

Cardiol Young 2020 May 20:1-8. Epub 2020 May 20.

Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.

Background: Pulmonary vascular disease resulting from CHDs may be the most preventable cause of pulmonary artery hypertension worldwide. Many children in developing countries still do not have access to early closure of clinically significant defects, and the long-term outcomes after corrective surgery remain unclear. Focused on long-term results after isolated ventricular septal defect repair, our review sought to determine the most effective medical therapy for the pre-operative management of elevated left-to-right shunts in patients with an isolated ventricular septal defect. Read More

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http://dx.doi.org/10.1017/S1047951120001146DOI Listing

Neuropsychological Status and Structural Brain Imaging in Adults With Simple Congenital Heart Defects Closed in Childhood.

J Am Heart Assoc 2020 Jun 19;9(11):e015843. Epub 2020 May 19.

Department of Cardiothoracic & Vascular Surgery Aarhus University Hospital Aarhus N Denmark.

Background Neurodevelopmental impairments are common in survivors of complex congenital heart defects (CHD). We report neuropsychological and brain imaging assessments in adults operated for isolated septal defects. Methods and Results Patients (mean age 25. Read More

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http://dx.doi.org/10.1161/JAHA.120.015843DOI Listing

"Holes-in-one": A case of concurrent windsock mitral valve, root abscess, and Gerbode defect.

Echocardiography 2020 May 19. Epub 2020 May 19.

Section of Cardiovascular Imaging, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH, USA.

Infective endocarditis is a heterogeneous disease with a wide array of pathological lesions. We present a 55-year-old man with severe mitral and aortic regurgitation on transthoracic echocardiography. Transesophageal echocardiogram characterized the mechanisms detecting a windsock mitral valve perforation, aortic root abscess, and Gerbode ventricular septal defect, with the deep transgastric view showing all three pathologies concurrently. Read More

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http://dx.doi.org/10.1111/echo.14703DOI Listing

Ruptured Coronary Sinus of Valsalva in the Setting of a Supracristal Ventricular Septal Defect.

Clin Pract Cases Emerg Med 2020 May 24;4(2):154-157. Epub 2020 Feb 24.

Long Island Community Hospital, Department of Cardiology, Patchogue, New York.

A sinus of Valsalva aneurysm (SOVA) is usually a silent entity until one of its complications arises, such as heart failure. SOVA itself is uncommon, but it is more frequently associated with a supracristal ventricular septal defect (SVSD). We present a 67-year-old man with a history of an asymptomatic SVSD who presented to the emergency department with signs and symptoms of heart failure. Read More

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http://dx.doi.org/10.5811/cpcem.2019.11.44008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220019PMC

Atrial septal defect closure in a midget toy poodle.

Open Vet J 2020 Apr 20;10(1):11-15. Epub 2020 Jan 20.

Department of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa 252-5201, Japan.

Background: Atrial septal defect (ASD) is a rare congenital cardiac disease, and there have been no reports about the treatment of ASD in midget breed dogs.

Case Description: A 7-month-old female toy poodle weighing 1.4 kg presented with cardiac enlargement. Read More

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http://dx.doi.org/10.4314/ovj.v10i1.3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193879PMC

Repair of ventricular septal defect through anterolateral thoracotomy with central cannulation: our experience.

Indian J Thorac Cardiovasc Surg 2020 Mar 16:1-7. Epub 2020 Mar 16.

Department of Cardio-Vascular and thoracic surgery, S.M.S. Medical College and Group of Hospitals, Jaipur, India.

Background: At present thoracotomy with femoro-femoral bypass is an established approach for minimally invasive open heart surgeries, but thoracotomy with conventional cannulation is yet to be established. We performed 54 cases of ventricular septal defect (VSD) closure via anterolateral thoracotomy approach with central cannulation. Here we are describing our results and experience of VSD closure via anterolateral thoracotomy approach. Read More

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http://dx.doi.org/10.1007/s12055-020-00929-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223385PMC

Biological basis of child health 3: development of the cardiovascular system and congenital heart defects.

Authors:
Doreen Crawford

Nurs Child Young People 2020 May 18. Epub 2020 May 18.

Crawford McKenzie consultancy, Colsterworth, England.

This article is the third in a series on the biological basis of child health. It outlines how the cardiovascular system develops during gestation and how congenital heart defects (CHDs) may arise in the process. The article details the pathophysiology and treatment of some of the common CHDs, including patent ductus arteriosus, atrial septal defect, ventricular septal defect and transposition of the great arteries. Read More

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http://dx.doi.org/10.7748/ncyp.2020.e1245DOI Listing

Risk of malformation after ondansetron in pregnancy: An updated systematic review and meta-analysis.

Birth Defects Res 2020 May 18. Epub 2020 May 18.

Service Hospitalo-Universitaire de Pharmaco-Toxicologie, Hospices Civils de Lyon, Lyon, France.

Ondansetron is increasingly used off label to treat nausea and vomiting during pregnancy. The main objective of this study was to evaluate the risk of major congenital malformations (MCM), cardiac defects and orofacial clefts associated with first trimester exposure to ondansetron using a meta-analytic approach. MEDLINE, ClinicalTrials. Read More

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http://dx.doi.org/10.1002/bdr2.1705DOI Listing

Collateral damage of COVID-19 pandemic: Delayed medical care.

Authors:
Saqib Masroor

J Card Surg 2020 May 17. Epub 2020 May 17.

Department of Surgery, Division of Cardiothoracic Surgery, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio.

During the COVID-19 pandemic, emergency room visits have drastically decreased for non-COVID conditions such as appendicitis, heart attack, and stroke. Patients may be avoiding seeking medical attention for fear of catching the deadly condition or as an unintended consequence of stay-at-home orders. This delay in seeking care can lead to increased morbidity and mortality, which has not been figured in the assessment of the extent of damage caused by this pandemic. Read More

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http://dx.doi.org/10.1111/jocs.14638DOI Listing

Pediatric Cardiology Specialist's Opinions Toward the Acceptability of Comfort Care for Congenital Heart Disease.

Pediatr Cardiol 2020 May 18. Epub 2020 May 18.

Center for Ethics, Children's Mercy Hospital, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA.

In order to evaluate physicians' willingness to seek legal action to mandate surgery when parents refuse surgery for various congenital heart lesions, we surveyed pediatric cardiologists and cardiovascular surgeons at 4 children's hospitals. We asked whether physicians would support parental refusal of surgery for specific heart defects and, if not, whether they would seek legal action to mandate surgery. We then analyzed associations between physicians' willingness to mandate surgery and national operative mortality rates for each lesion. Read More

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http://dx.doi.org/10.1007/s00246-020-02367-2DOI Listing

Caudal vena cava aneurysm in a cat with Eisenmenger Syndrome.

J Vet Med Sci 2020 May 15. Epub 2020 May 15.

Department of Veterinary Medical Imaging, College of Veterinary Medicine, Konkuk University.

A seven-month-old cat was referred for evaluation of exercise intolerance and open-mouth breathing. Based on ultrasonographic examination, caudal vena cava (CVC) aneurysm associated with right congestive heart failure resulting from congenital heart disease was diagnosed. Conservative treatment for alleviating pulmonary hypertension mildly improved the clinical signs and decreased the heart size and CVC aneurysm diameter. Read More

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http://dx.doi.org/10.1292/jvms.19-0518DOI Listing

Ventricular Septal Defect Pulmonary Atresia: Provisional Bifurcation Strategy for Confluence Stenosis During Patent Ductus Arteriosis Stenting.

Can J Cardiol 2020 Mar 5. Epub 2020 Mar 5.

Department of Cardiology, Post Graduate Institute for Medical Education and Research (PGIMER), Chandigarh, India. Electronic address:

Neonates with pulmonary atresia survive only if duct patency is maintained before staged surgical repair. Ductal stenting is an effective alternative to conventional shunt surgery, as it avoids thoracotomy. With today's generation of coronary stents having better profile, flexibility, and trackability, it may be achieved safely, with less difficulty than previously described. Read More

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http://dx.doi.org/10.1016/j.cjca.2020.02.094DOI Listing

Peri-membranous ventricular septal defect following His bundle lead implantation.

J Cardiovasc Electrophysiol 2020 May 15. Epub 2020 May 15.

Heart Center, University Hospital Ghent, Belgium.

His bundle pacing (HBP) offers physiologic pacing by placing the pacing lead directly to the His bundle. We present a case in which a HBP lead, implanted at the fragile membranous septum, resulted in a persistent restrictive peri-membranous ventricular septal defect (VSD). This complication of HBP has not been reported before but brings new insights in the discussion regarding the optimal position of a pacing lead in the ventricular septum. Read More

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http://dx.doi.org/10.1111/jce.14553DOI Listing

Impact of Right Ventricular Dilatation in Patients with Atrial Septal Defect.

J Interv Cardiol 2020 27;2020:9509105. Epub 2020 Apr 27.

Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Objective: The aim of this study was to examine the relationship between right ventricular (RV) volume and exercise capacity in adult patients with atrial septal defect (ASD) and to determine the degree of RV dilatation for transcatheter ASD closure.

Background: RV dilatation is an indication of transcatheter ASD closure; however, few studies have reported the clinical significance of RV dilatation.

Methods: We enrolled 82 consecutive patients (mean age, 49 ± 18 years; female, 68%) who underwent cardiac magnetic resonance imaging and symptom-limited cardiopulmonary exercise test before ASD closure. Read More

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http://dx.doi.org/10.1155/2020/9509105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204162PMC
April 2020
1.318 Impact Factor

Adverse impact of univentricular pacing for the patient with functional single ventricle: successful conversion to cardiac resynchronization therapy.

Surg Case Rep 2020 May 13;6(1):101. Epub 2020 May 13.

Division of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757, Asahimachi-dori, Niigata City, 951-8510, Japan.

Background: In a Fontan candidate, univentricular pacing may cause delay in interventricular conduction, which induces asynchronous contraction. Cardiac resynchronization therapy is expected to be an effective mode of therapy in such a case.

Case Presentation: A 7-month-old girl, diagnosed with dextrocardia, congenitally corrected transposition of the great artery [situs solitus, L-loop, and L-transposition], ventricular septal defect, infundibular and pulmonary valvular stenosis, and straddling of the tricuspid valve, was considered as a candidate for the Fontan procedure. Read More

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http://dx.doi.org/10.1186/s40792-020-00863-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221050PMC

Cardiac Neural Crest Cells: Their Rhombomeric Specification, Migration, and Association with Heart and Great Vessel Anomalies.

Cell Mol Neurobiol 2020 May 13. Epub 2020 May 13.

Department of Cardiovascular Surgery, University of Ottawa Heart Institute and School of Epidemiology, Ottawa, ON, Canada.

Outflow tract abnormalities are the most frequent congenital heart defects. These are due to the absence or dysfunction of the two main cell types, i.e. Read More

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http://dx.doi.org/10.1007/s10571-020-00863-wDOI Listing

Adult Ventricular Septal Defect Repair Using a Robotic Totally Endoscopic Approach: A Case Report.

Innovations (Phila) 2020 May 14:1556984520922978. Epub 2020 May 14.

12246 Section of Cardiac Surgery, Department of Surgery, University of Chicago Medicine, IL, USA.

The growth and advancement of minimally invasive cardiac surgery in recent years has allowed robotic and totally endoscopic procedures to become safe and effective options for the treatment of patients with various diseases of the heart. However, despite these advances, outcome data for robotic correction of congenital cardiac anomalies are scarce. This is particularly true for robotic ventricular septal defect (VSD) repair with initial experiences only recently having been published by a single group. Read More

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http://dx.doi.org/10.1177/1556984520922978DOI Listing

Safety and efficacy of transcatheter closure of outlet-type ventricular septal defects in children and adults with Amplatzer Duct Occluder II.

J Formos Med Assoc 2020 May 10. Epub 2020 May 10.

Department of Cardiology, National Taiwan University Children's Hospital, Taipei, Taiwan. Electronic address:

Background/purpose: Outlet-type VSD is frequently associated with aortic valve prolapse that surgery is frequently required. The literature regarding outcomes of transcatheter closure of outlet-type VSDs is scant. This study was conducted to know the safety and efficacy of transcatheter closure of outlet-type ventricular septal defects (VSDs) with Amplatzer Duct Occluder II (ADO II). Read More

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http://dx.doi.org/10.1016/j.jfma.2020.04.015DOI Listing

Surgical management of embolized Amplatzer septal occluder into the left ventricle tangled with the mitral valve.

J Card Surg 2020 May 12. Epub 2020 May 12.

Department of Cardiac Surgery, Leon University Hospital, Leon, Spain.

Device embolization is a rare major complication of atrial septal defect percutaneous closures which requires surgical management if noninvasive retrieval fails. We report a symptomatic delayed embolization of an Amplatzer septal occluder device into the left ventricle outflow tract tangled with the mitral valve, complicated with ventricular arrhythmias and cardiac tamponade during percutaneous retrieval attempt. Emergent surgical treatment was performed, requiring a combined approach through the right atrium and the aorta for surgical removal. Read More

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http://dx.doi.org/10.1111/jocs.14621DOI Listing

A case of giant main pulmonary artery aneurysm associated with complicated congenital heart disease and simultaneous chronic pulmonary artery dissection.

J Cardiothorac Surg 2020 May 12;15(1):87. Epub 2020 May 12.

Department of Radiology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Qingyang District, Chengdu, 610072, Sichuan, China.

Background: Pulmonary artery aneurysm (PAA), usually associated with congenital heart disease (CHD), is a very rare clinical condition. Pulmonary artery dissection (PAD) is considered the most life-threatening complication of PAA, and patients can progress from being asymptomatic to sudden death. We report the following case of PAA associated with complicated congenital heart disease and simultaneous chronic PAD. Read More

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http://dx.doi.org/10.1186/s13019-020-01139-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216660PMC

Monitored Anesthesia Care of Two Patients with Highly Elevated Subpulmonic Ventricular Pressure due to Adult Congenital Heart Disease.

Case Rep Cardiol 2020 11;2020:2040561. Epub 2020 Jan 11.

Department of Anesthesiology, Yokohama City University Medical Center, 4-57 Urahune, Minami-ku, Yokohama 2320024, Japan.

Procedural sedation and analgesia for patients with adult congenital heart disease (ACHD) and highly elevated subpulmonic ventricular pressure require proper anesthesia care to prevent a pulmonary hypertensive crisis. We describe the monitored anesthesia care (MAC) of two patients with ACHD (a complete atrioventricular septal defect and congenitally corrected transposition of the great arteries) and highly elevated subpulmonic ventricular pressure. In both patients, preprocedural transthoracic echocardiography was useful for detecting severely elevated subpulmonic ventricular pressure. Read More

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http://dx.doi.org/10.1155/2020/2040561DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201478PMC
January 2020