13,848 results match your criteria Ventricular Repair


Perioperative management of patients with left ventricular assist devices undergoing repair of hip fracture.

J Clin Anesth 2019 Jan 18;56:24-26. Epub 2019 Jan 18.

Department of Anesthesiology, Columbia University, 622 W 168th Street, New York, NY 10032, United States. Electronic address:

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http://dx.doi.org/10.1016/j.jclinane.2018.12.037DOI Listing
January 2019

Long-Range Guidance of Spinal Commissural Axons by Netrin1 and Sonic Hedgehog from Midline Floor Plate Cells.

Neuron 2019 Jan 11. Epub 2019 Jan 11.

Laboratory of Brain Development and Repair, The Rockefeller University, New York, NY 10065, USA; Department of Biology, Stanford University, Stanford, CA 94305, USA. Electronic address:

An important model for axon pathfinding is provided by guidance of embryonic commissural axons from dorsal spinal cord to ventral midline floor plate (FP). FP cells produce a chemoattractive activity, comprised largely of netrin1 (FP-netrin1) and Sonic hedgehog (Shh), that can attract the axons at a distance in vitro. netrin1 is also produced by ventricular zone (VZ) progenitors along the axons' route (VZ-netrin1). Read More

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http://dx.doi.org/10.1016/j.neuron.2018.12.025DOI Listing
January 2019

Role of interleukin-17 in acute myocardial infarction.

Mol Immunol 2019 Jan 17;107:71-78. Epub 2019 Jan 17.

Unidad de Investigación Médica en Inmunología, UMAE, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, México. Electronic address:

Acute myocardial infarction (AMI) is a leading cause of death worldwide. Myocardial necrosis generates damage signals and triggers an intense inflammatory response. Many cytokines that contribute to repair tissue can also cause adverse left ventricular remodeling and heart failure. Read More

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http://dx.doi.org/10.1016/j.molimm.2019.01.008DOI Listing
January 2019

Do Guideline-Based Indications Result in an Outcome Penalty for Patients With Severe Aortic Regurgitation?

JACC Cardiovasc Imaging 2019 Jan 9. Epub 2019 Jan 9.

Pôle de Recherche Cardiovasculaire, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain and the Divisions of Cardiology and Cardiothoracic Surgery, Cliniques Universitaires Saint-Luc, Brussels, Belgium. Electronic address:

Objectives: The present study examines whether improvements have reduced the negative impact of guideline triggers on postoperative outcomes.

Background: European and American guidelines for the management of severe aortic regurgitation (AR) define the triggers for AR surgery. These triggers are based on the results of studies performed in the 1990s analyzing outcomes of patients who underwent AR surgery in the 1980s. Read More

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http://dx.doi.org/10.1016/j.jcmg.2018.11.022DOI Listing
January 2019

Tetralogy of Fallot: morphological variations and implications for surgical repair.

Eur J Cardiothorac Surg 2019 Jan 16. Epub 2019 Jan 16.

Department of Paediatric Cardiac Surgery, Birmingham Children's Hospital, Birmingham, UK.

Objectives: Tetralogy of Fallot is characterized by anterocephalad deviation of the outlet septum, along with abnormal septoparietal trabeculations, which lead to subpulmonary infundibular stenosis. Archives of retained hearts are an important resource for improving our understanding of congenital heart defects and their morphological variability. This study aims to define variations in aortic override, coronary arterial patterns and ventricular septal defects in tetralogy of Fallot as observed in a morphological archive, highlighting implications for surgical management. Read More

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http://dx.doi.org/10.1093/ejcts/ezy474DOI Listing
January 2019

Circulating Transforming Growth Factor-β and Aortic Dilation in Patients with Repaired Congenital Heart Disease.

Sci Rep 2019 Jan 17;9(1):162. Epub 2019 Jan 17.

Department of Paediatrics and Adolescent Medicine, Queen Mary Hospital, The University of Hong Kong, Pok Fu Lam, China.

This study determined the circulating levels of TGF-β1 and its association with aortic dilation and elastic properties in congenital heart patients. Forty-six patients after tetralogy of Fallot (TOF) repair, 21 patients post arterial switch and 15 patients post atrial switch for transposition of the great arteries (TGA), 27 patients post Fontan procedure, and 36 controls were studied. Aortic dimensions and elastic properties and ventricular function were assessed by echocardiography. Read More

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http://dx.doi.org/10.1038/s41598-018-36458-1DOI Listing
January 2019

Post-Infarction Left Ventricular Aneurysm Repair.

Braz J Cardiovasc Surg 2018 Nov-Dec;33(6):645-646

Department of Surgery and Anatomy, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil.

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http://dx.doi.org/10.21470/1678-9741-2018-0188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326439PMC
January 2019

Relative Impact of Right Ventricular Electromechanical Dyssynchrony Versus Pulmonary Regurgitation on Right Ventricular Dysfunction and Exercise Intolerance in Patients After Repair of Tetralogy of Fallot.

J Am Heart Assoc 2019 Jan;8(2):e010903

1 Division of Cardiology Labatt Family Heart Centre and Department of Paediatrics Hospital for Sick Children and University of Toronto Toronto Ontario Canada.

Background The relative impact of right ventricular ( RV ) electromechanical dyssynchrony versus pulmonary regurgitation ( PR ) on exercise capacity and RV function after tetralogy of Fallot repair is unknown. We aimed to delineate the relative effects of these factors on RV function and exercise capacity. Methods and Results We retrospectively analyzed 81 children with tetralogy of Fallot repair using multivariable regression. Read More

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http://dx.doi.org/10.1161/JAHA.118.010903DOI Listing
January 2019
1 Read

Endocardial Notch Signaling Promotes Cardiomyocyte Proliferation in the Regenerating Zebrafish Heart through Wnt Pathway Antagonism.

Cell Rep 2019 Jan;26(3):546-554.e5

Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address:

Previous studies demonstrate that the regenerative zebrafish heart responds to injury by upregulating Notch receptors in the endocardium and epicardium. Moreover, global suppression of Notch activity following injury impairs cardiomyocyte proliferation and induces scarring. However, the lineage-specific requirements for Notch signaling and full array of downstream targets remain unidentified. Read More

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http://dx.doi.org/10.1016/j.celrep.2018.12.048DOI Listing
January 2019

Circulating biomarkers of left ventricular hypertrophy in pediatric coarctation of the aorta.

Congenit Heart Dis 2019 Jan 16. Epub 2019 Jan 16.

Division of Cardiology, Department of Pediatrics, University of Colorado Denver, Aurora, Colorado.

Objective: Patients undergoing surgical repair of aortic coarctation have a 50% risk of pathologic left ventricular remodeling (increased left ventricular mass or relative wall thickness). Endothelin 1, ST2, galectin 3, norepinephrine and B-natriuretic peptide are biomarkers that have been associated with pathologic LV change in adult populations but their predictive value following pediatric coarctation repair are not known.

Hypothesis: Biomarker levels at coarctation repair will predict persistent left ventricular remodeling at 1-year follow up. Read More

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http://doi.wiley.com/10.1111/chd.12744
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http://dx.doi.org/10.1111/chd.12744DOI Listing
January 2019
1 Read

Management issues during postinfarction ventricular septal defect and role of perioperative optimization: A case series.

Ann Card Anaesth 2019 Jan-Mar;22(1):30-34

Department of Cardiothoracic Surgery, Dubai Hospital, Al Baraha, Dubai, United Arab Emeritus.

The development of a myocardial infarction ventricular septal rupture is a rare fatal complication, and the surgical repair is the treatment of choice. In most of the scenarios, the operation will be done as an emergency procedure that carries high mortality. Prognosis of these patients depends on prompt echocardiographic diagnosis and the proactive medical and surgical therapy. Read More

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http://dx.doi.org/10.4103/aca.ACA_189_17DOI Listing
January 2019
1 Read

Rupture of sinus of valsalva - A 15 years single institutional retrospective review: Preoperative heart failure has an impact on post operative outcome?

Ann Card Anaesth 2019 Jan-Mar;22(1):24-29

Department of Cardiology, Sri Sathya Sai Institute of Higher Medical Sciences, Bengaluru, Karnataka, India.

Background: We reviewed our experience with ruptured sinus of Valsalva aneurysms (RSOV) to determine a correlation with preexisting heart failure (HF) and coexisting cardiac lesions (aortic regurgitation [AR] and ventricular septal defect [VSD]) to postoperative left ventricular (LV) dysfunction and postoperative outcomes.

Materials And Methods: Retrospective review of RSOV cases over 15 years showed that RSOV repair was done in 87 patients. We looked for patients who presented with HF and patients having AR and/or VSDs. Read More

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http://www.annals.in/text.asp?2019/22/1/24/250192
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http://dx.doi.org/10.4103/aca.ACA_243_17DOI Listing
January 2019
2 Reads

Ministernotomy or sternotomy in isolated aortic valve replacement? Early results.

Kardiochir Torakochirurgia Pol 2018 Dec 31;15(4):213-218. Epub 2018 Dec 31.

Department of Cardiovascular Surgery and Transplantology, Jagiellonian University, John Paul II Hospital, Krakow, Poland.

Introduction: Aortic valve replacement (AVR) is the gold standard in treating symptomatic aortic valve defects. To improve the healing process and limit the trauma, the minimally invasive approach was introduced.

Aim: To compare the peri- and post-operative results of aortic valve replacement performed via conventional full sternotomy (con-AVR) and of AVR performed via partial upper sternotomy (mini-AVR). Read More

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https://www.termedia.pl/doi/10.5114/kitp.2018.80916
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http://dx.doi.org/10.5114/kitp.2018.80916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329886PMC
December 2018
3 Reads

Urapidil, compared to nitroglycerin, has better clinical safety in the treatment of hypertensive patients with acute heart failure: a meta-analysis.

Drug Des Devel Ther 2019 27;13:161-172. Epub 2018 Dec 27.

Department of Orthopaedics, Tianjin Medical University General Hospital, Heping District, Tianjin 300052, PR China,

Objectives: The application of urapidil for treating hypertensive patients with acute heart failure in the emergency department remains controversial. Our objective was to organize the relevant articles and assess the clinical indexes between urapidil and nitroglycerin.

Materials And Methods: PubMed, EMBASE, the Cochrane Library and China National Knowledge Infrastructure were searched for randomized studies that compared urapidil treatment with nitroglycerin treatment for hypertensive patients with acute heart failure. Read More

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http://dx.doi.org/10.2147/DDDT.S185972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312052PMC
December 2018

Totally endoscopic ventricular septal defect repair using bilateral femoral arterial cannulation in an 8-year-old girl.

Int J Surg Case Rep 2019 Jan 9;55:4-6. Epub 2019 Jan 9.

Institute of Preventive Medicine and Public Health, Hanoi Medical University (HMU), Hanoi, Viet Nam.

Introduction: There are few reports on applying totally endoscopic surgery (TES) for repairing ventricular septal defect (VSD), especially in children.

Case Presentation: We described an 8-year-old girl, weighing 17 kg, who was diagnosed with peri-membranous VSD and patent ductus arteriosus (PDA). The patient had undergone trans-catheter PDA closure first, and 3 weeks later, TES was performed for VSD repair through 4 small trocars (one 12 mm trocar and three 5 mm trocars) without robotic assistance. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.12.002DOI Listing
January 2019
1 Read

The Society of Thoracic Surgeons Congenital Heart Surgery Database: 2019 Update on Outcomes and Quality.

Ann Thorac Surg 2019 Jan 11. Epub 2019 Jan 11.

Division of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland; Division of Cardiovascular Surgery, Department of Surgery, Johns Hopkins All Children's Heart Institute, Johns Hopkins All Children's Hospital and Florida Hospital for Children, Saint Petersburg, Tampa, and Orlando, Florida.

The Society of Thoracic Surgeons Congenital Heart Surgery Database is a comprehensive clinical outcomes registry which captures almost all pediatric cardiac surgical operations in the United States. It is the platform for all activities of The Society of Thoracic Surgeons related to the analysis of outcomes and the improvement of quality in this subspecialty. This article summarizes current aggregate national outcomes in congenital and pediatric cardiac surgery and reviews related activities in the areas of quality measurement, performance improvement, and transparency. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00034975193006
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http://dx.doi.org/10.1016/j.athoracsur.2018.12.016DOI Listing
January 2019
8 Reads

Chronic CaMKII inhibition reverses cardiac function and cardiac reserve in HF mice.

Life Sci 2019 Jan 9. Epub 2019 Jan 9.

Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China. Electronic address:

Aims: The present study was to explore the impact of KN93 - a specific inhibitor of CaMKII - on cardiac function and cardiac reserve in HF mice.

Main Methods: We have generated pressure-overload HF mice using modified transverse aortic constriction (TAC) method. For acute inhibition (AI) experiment, HF mice were randomly divided into HF group, HF + KN93 AI group and HF + KN92 AI group, using sham mice as control. Read More

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http://dx.doi.org/10.1016/j.lfs.2019.01.010DOI Listing
January 2019

Optimal timing of ventricular septal defect repair: Is it worth the weight?

J Thorac Cardiovasc Surg 2018 Dec 20. Epub 2018 Dec 20.

Duke Children's Pediatric and Congenital Heart Center, Duke Children's Hospital, Durham, NC.

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http://dx.doi.org/10.1016/j.jtcvs.2018.12.029DOI Listing
December 2018

To repair or not to repair: a case report of atrioventricular groove hematoma during mitral valve surgery.

J Cardiothorac Surg 2019 Jan 9;14(1). Epub 2019 Jan 9.

Department of Thoracic and Cardiovascular Surgery, Yokohama Sakae Kyosai Hospital, 132 Katsura-cho, Sakae-ku, Yokohama, Kanagawa, 247-8581, Japan.

Background: Atrioventricular groove hematomas during mitral valve surgery range from simple hematomas to complex atrioventricular disruptions that cause frank rupture with massive bleeding and subsequent mortality. A small or moderate-sized hematoma is reported to be present in the left atrioventricular groove in 10 to 30% of all patients immediately after mitral valve replacement. Despite the fact that atrioventricular groove hematomas are inherently unstable and unpredictable, conservative strategies are recommended due to the high mortality associated with additional surgical repair. Read More

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http://dx.doi.org/10.1186/s13019-018-0828-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327444PMC
January 2019

Surgical repair of a ruptured congenital sinus of Valsalva aneurysm: 10-year experience with 286 cases.

Eur J Cardiothorac Surg 2019 Jan 8. Epub 2019 Jan 8.

Department of Cardiovascular Surgery, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Objectives: Surgical intervention is the main treatment for a ruptured congenital sinus of Valsalva aneurysm (SVA). However, reports on the surgical experience are scarce. We retrospectively analysed the cases of our centre to summarize our 10-year experience. Read More

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https://academic.oup.com/ejcts/advance-article/doi/10.1093/e
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http://dx.doi.org/10.1093/ejcts/ezy437DOI Listing
January 2019
3 Reads

Prenatal brain imaging for predicting postnatal hydrocephalus treatment in fetuses that had neural tube defect repair.

Ultrasound Obstet Gynecol 2019 Jan 8. Epub 2019 Jan 8.

Department of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine, Baylor College of Medicine & Texas Children's Hospital, Houston, TX, United States.

Objectives: To determine if fetal brain imaging in fetuses that underwent prenatal repair of neural tube defect (NTD) can predict the need for postnatal hydrocephalus treatment (HT) in the first year postpartum.

Methods: This was a prospective study of fetuses diagnosed with open neural tube defect that had in-utero myelomeningocele repair between April 2014 and April 2016. Independent variables were collected from four chronological sets of fetal images: pre-surgery ultrasound, pre-surgery MRI, 6-week post-surgery MRI and pre-delivery ultrasound. Read More

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http://doi.wiley.com/10.1002/uog.20212
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http://dx.doi.org/10.1002/uog.20212DOI Listing
January 2019
2 Reads

Novel Left Atrioventricular Valvuloplasty for Atrioventricular Septal Defect.

Ann Thorac Surg 2018 Oct 25. Epub 2018 Oct 25.

Mt. Fuji Shizuoka Children's Hospital Department of Cardiovascular Surgery.

An infant boy with 21 trisomy was diagnosed with complete atrioventricular septal defect (CAVSD)-Rastelli type A with parachute left atrioventricular valve and absent left mural leaflet. Biventricular repair was difficult in infancy because the left ventricular volume and left atrioventricular valve annulus were too small. After two pulmonary artery bandings, the left atrioventricular valve annulus increased to 85% of normal mitral valve, and the left ventricular end-diastolic volume increased to 98% of normal. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2018.08.093DOI Listing
October 2018

Prenatal Diagnosis and Postnatal Outcome of Fetuses with Pulmonary Atresia and Ventricular Septal Defect.

Ultraschall Med 2019 Jan 7. Epub 2019 Jan 7.

Division of Prenatal Medicine, University-Hospital of Cologne, Germany.

Purpose:  To assess the intrauterine course, associated conditions and postnatal outcome of fetuses with pulmonary atresia with ventricular septal defect (PAVSD).

Methods:  All cases of PAVSD diagnosed prenatally over a period of 10 years with a minimum follow-up of 6.5 years were retrospectively collected in 3 tertiary referral centers. Read More

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http://dx.doi.org/10.1055/a-0770-2832DOI Listing
January 2019

Serial Follow-up of Two Surgical Strategies for the Repair of Tetralogy of Fallot.

Semin Thorac Cardiovasc Surg 2019 Jan 4. Epub 2019 Jan 4.

University of Rochester Medical Center, Department of Surgery, Division of Cardiac Surgery. Electronic address:

Objective: Adverse events following tetralogy of Fallot repair include arrhythmia, reoperation and death. While limiting the right ventriculotomy mitigates these events over the short- and intermediate-term, the impact over the long-term is unknown.

Methods: Children requiring tetralogy of Fallot repair were divided into two groups: extended right ventriculotomy vs limited right ventriculotomy with transatrial ventricular septal defect closure. Read More

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http://dx.doi.org/10.1053/j.semtcvs.2019.01.006DOI Listing
January 2019
1 Read

Single-centre first experience with transapical transcatheter mitral valve replacement with an apical tether: factors influencing screening outcomes.

Interact Cardiovasc Thorac Surg 2019 Jan 2. Epub 2019 Jan 2.

Department of Cardiothoracic Surgery, Oslo University, Oslo, Norway.

Objectives: Transcatheter mitral valve replacement has recently been introduced as an alternative treatment option for severe mitral regurgitation. We present our single-centre first experience with screening and implantation outcomes.

Methods: Twenty-five patients with mitral regurgitation grades 3 and 4 were screened based on study inclusion/exclusion criteria, echocardiography and computed tomography imaging. Read More

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http://dx.doi.org/10.1093/icvts/ivy343DOI Listing
January 2019
1 Read

Long-term results of surgical treatment of secondary severe mitral regurgitation in patients with end-stage heart failure: Advantage of prosthesis insertion.

Arch Cardiovasc Dis 2018 Dec 29. Epub 2018 Dec 29.

Department of Cardiology, La Timone Hospital, AP-HM, 13005 Marseille, France. Electronic address:

Background: Surgical treatment of secondary mitral regurgitation (SMR) is controversial.

Aim: To analyse outcome after undersizing annuloplasty (UA) and mitral valve replacement (MVR).

Methods: Consecutive patients operated on for severe SMR, with left ventricular ejection fraction (LVEF)<40% and refractory CHF, were included. Read More

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http://dx.doi.org/10.1016/j.acvd.2018.09.006DOI Listing
December 2018

Role of imaging in novel mitral technologies-echocardiography and computed tomography.

Ann Cardiothorac Surg 2018 Nov;7(6):799-811

Cardiology Division, UTHealth McGovern Medical School, Houston, TX, USA.

As minimally invasive cardiovascular procedures gain popularity, novel transcatheter mitral valve repair devices continue to emerge. The success of these technologies is critically dependent on high quality imaging performed at all stages: patient selection, intervention planning, intraprocedural guidance, monitoring complications and follow-up. We present an overview of specific imaging requirements and challenges applicable to mitral valve interventional techniques. Read More

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http://dx.doi.org/10.21037/acs.2018.09.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288221PMC
November 2018

Early experience with the Intrepid system for transcatheter mitral valve replacement.

Ann Cardiothorac Surg 2018 Nov;7(6):792-798

Columbia University Medical Center/NY Presbyterian Hospital, New York, NY, USA.

Severe mitral regurgitation is common and results in a poor prognosis in patients with either symptoms or severe ventricular dilatation. While mitral regurgitation has traditionally necessitated surgical repair or replacement, new transcatheter methods, such as the IntrepidTM transcatheter mitral valve replacement, has recently emerged. The Intrepid system is a circular, self-expanding, tri-leaflet bovine pericardial prosthesis housed within a nitinol frame. Read More

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http://dx.doi.org/10.21037/acs.2018.10.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288225PMC
November 2018

Complexities of transcatheter mitral valve replacement (TMVR) and why it is not transcatheter aortic valve replacement (TAVR).

Ann Cardiothorac Surg 2018 Nov;7(6):724-730

Department of Cardiovascular Surgery, Houston Methodist Hospital, Houston, Texas, USA.

Transcatheter mitral valve replacement (TMVR) is currently being investigated as a procedural alternative to surgical mitral valve repair or replacement (SMVR). Early data from first-in-man trials with current devices suggest that TMVR is technically feasible but carries a high mortality. This is substantially different from the early success transcatheter aortic valve replacement (TAVR) has seen and is related to complexities of the mitral valve anatomy, differences in pathology that require mitral valve replacement as well as the impact that mitral valve replacement has on physiology and cardiac function, irrespective of the modality by which the mitral valve is replaced. Read More

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http://dx.doi.org/10.21037/acs.2018.10.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288216PMC
November 2018
1 Read

When less is more: Is valve repair the optimal intervention for aortic insufficiency at time of ventricular assist device implantation?

J Thorac Cardiovasc Surg 2018 Nov 27. Epub 2018 Nov 27.

Division of Cardiovascular Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, Pa. Electronic address:

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http://dx.doi.org/10.1016/j.jtcvs.2018.11.044DOI Listing
November 2018
1 Read

Common Arterial Trunk: Physiology, Imaging, and Management.

Semin Cardiothorac Vasc Anesth 2018 Dec 29:1089253218821382. Epub 2018 Dec 29.

3 Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Common arterial trunk (CAT), or truncus arteriosus, is a rare form of cyanotic congenital heart disease and is highly associated with DiGeorge syndrome (microdeletion 22q11.2). Prenatal diagnosis is highly feasible, allowing proper delivery planning and postnatal management. Read More

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http://journals.sagepub.com/doi/10.1177/1089253218821382
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http://dx.doi.org/10.1177/1089253218821382DOI Listing
December 2018
6 Reads

Changes in right ventricular longitudinal function: primary mitral and concomitant tricuspid valve repair.

Perfusion 2018 Dec 31:267659118820776. Epub 2018 Dec 31.

1 Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Objectives:: To evaluate the impact of concomitant tricuspid valve (TV) repair on the right ventricular (RV) function postoperatively and within the 6 months following degenerative mitral valve (MV) repair.

Methods:: The prospective study included 37 patients (mean age 57.32 ± 2. Read More

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http://dx.doi.org/10.1177/0267659118820776DOI Listing
December 2018
2 Reads
1.083 Impact Factor

Surgical repair of Tetralogy of Fallot following primary palliation: Right ventricular outflow track stenting versus modified Blalock-Taussig shunt.

Indian Heart J 2018 Dec 24;70 Suppl 3:S394-S398. Epub 2018 Jun 24.

Department of Neuroscience, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: Tetralogy of Fallot (TOF) is a cyanotic disease requiring early intervention. We assessed the effect of right ventricular outflow tract (RVOT) stenting versus modified Blalock-Taussig shunt (mBTS) on outcomes of surgical repair of TOF.

Methods: Fifteen palliated TOF infants underwent complete repair surgery. Read More

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http://dx.doi.org/10.1016/j.ihj.2018.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309724PMC
December 2018
1 Read

Continuous Direct Left Atrial Pressure: Intraprocedural Measurement Predicts Clinical Response Following MitraClip Therapy.

JACC Cardiovasc Interv 2018 Dec 21. Epub 2018 Dec 21.

University Heart Center Zürich, University Hospital of Zurich, Zurich, Switzerland. Electronic address:

Objectives: The aim of this study was to assess the additional utility of measuring left atrial (LA) pressure as a complement to transesophageal echocardiography (TEE) and Doppler imaging.

Background: The efficacy of the MitraClip (MC) is assessed intraoperatively by TEE. However, TEE measures are operator dependent and can be influenced by left ventricular (LV) function and changes in LA compliance. Read More

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http://dx.doi.org/10.1016/j.jcin.2018.07.051DOI Listing
December 2018

Feasibility, safety, and short-term outcome of totally thoracoscopic mitral valve procedure.

J Cardiothorac Surg 2018 Dec 29;13(1):133. Epub 2018 Dec 29.

Department of Cardiac Surgery, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.

Background: The totally thoracoscopic procedure for mitral valve (MV) disease is a minimally invasive method. We investigated the procedure's feasibility, safety and effectiveness when it was performed by an experienced operator.

Methods: We retrospectively analysed 53 consecutive patients with MV disease treated between December 2014 and April 2017 by minimally invasive procedures. Read More

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http://dx.doi.org/10.1186/s13019-018-0819-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310972PMC
December 2018
4 Reads

Incremental value of three-dimensional transthoracic echocardiography over the two-dimensional modality in the assessment of right heart compression and dysfunction produced by pectus excavatum.

Echocardiography 2019 01 28;36(1):150-163. Epub 2018 Dec 28.

Division of Cardiothoracic Surgery, University of Alabama at Birmingham, Birmingham, Alabama.

The usefulness of two-dimensional transthoracic echocardiography (2DTTE) in the assessment of right heart compression and dysfunction produced by pectus excavatum chest wall deformity has been well described in the literature by several investigators. However, there is a paucity of reports describing incremental value of live/real time three-dimensional transthoracic echocardiography (3DTTE) over the two-dimensional technique in the evaluation of right heart function in these patients. We present a severe case of pectus excavatum chest wall deformity in a young male, in whom 3DTTE provided incremental value over standard 2DTTE in assessing compression of the right heart before surgery and marked improvement in right heart function parameters following surgical repair. Read More

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http://dx.doi.org/10.1111/echo.14230DOI Listing
January 2019

Mid-term outcomes (up to 5 years) of percutaneous edge-to-edge mitral repair in the real-world according to regurgitation mechanism: A single-center experience.

Catheter Cardiovasc Interv 2018 Dec 27. Epub 2018 Dec 27.

Department of Cardiac Surgery, San Raffaele Scientific Institute, Milan, Italy.

Objectives: To report mid-term results after MitraClip repair, according to mitral regurgitation (MR) mechanism, in a real-world single-center experience.

Background: Mid-term outcomes of percutaneous edge-to-edge mitral repair in the real world are still limited.

Methods: We assessed the follow-up results of patients treated with MitraClip at a single high-volume mitral center from 2008 to 2016. Read More

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http://dx.doi.org/10.1002/ccd.28029DOI Listing
December 2018

Late presenting complete heart block after surgical repair of ventricular septal defect.

Egypt Heart J 2018 Dec 19;70(4):455-459. Epub 2018 Nov 19.

Division of Pediatric Cardiology, Cardiac Science Department, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.

Late onset of complete heart block is a life-threatening uncommon complication after surgical repair of congenital heart diseases. In this report, we discuss two cases of Perimembranous ventricular septal defect (VSD) that had late presentation of complete heart block after surgical repair. We are aiming to highlight this unusual complication for more awareness, better understanding and management of this unusual complication after pediatric cardiac surgery. Read More

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http://dx.doi.org/10.1016/j.ehj.2018.10.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303357PMC
December 2018
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Cardiac recovery and outcome of neonates and infants presenting with severe aortic coarctation and depressed cardiac function.

Egypt Heart J 2018 Dec 30;70(4):255-260. Epub 2018 May 30.

Section of Pediatric Cardiac Intensive Care, King Abdulaziz Medical City, Department of Cardiac Sciences, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.

Objectives: Coarctation of the aorta represents 5-8% of all congenital heart diseases Children with severe coarctation of the aorta may present with significant depression of myocardial function. The aim of this study is to identify short and midterm outcomes of neonates and infants with isolated coarctation of the aorta and depressed left ventricular systolic function with regard to recovery of their cardiac function.

Methods: All patients with isolated coarctation of the aorta who underwent surgical repair between December 2002 and December 2015 were retrospectively reviewed in a cohort study. Read More

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http://dx.doi.org/10.1016/j.ehj.2018.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303275PMC
December 2018

Reliability of MR Imaging-Based Posterior Fossa and Brain Stem Measurements in Open Spinal Dysraphism in the Era of Fetal Surgery.

AJNR Am J Neuroradiol 2019 Jan 27;40(1):191-198. Epub 2018 Dec 27.

Academic Department of Development and Regeneration, Cluster Woman and Child (L.D.C., J.D.), Group Biomedical Sciences, KU Leuven, Leuven, Belgium.

Background And Purpose: Fetal MR imaging is part of the comprehensive prenatal assessment of fetuses with open spinal dysraphism. We aimed to assess the reliability of brain stem and posterior fossa measurements; use the reliable measurements to characterize fetuses with open spinal dysraphism versus what can be observed in healthy age-matched controls; and document changes in those within 1 week after prenatal repair.

Materials And Methods: Retrospective evaluation of 349 MR imaging examinations took place, including 274 in controls and 52 in fetuses with open spinal dysraphism, of whom 23 underwent prenatal repair and had additional early postoperative MR images. Read More

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http://dx.doi.org/10.3174/ajnr.A5930DOI Listing
January 2019

Aggregation of Child Cardiac Progenitor Cells into Spheres Activates Notch Signaling and Improves Treatment of Right Ventricular Heart Failure.

Circ Res 2018 Dec 28. Epub 2018 Dec 28.

Biomedical Engineering, Emory University School of Medicine.

Rationale: Congenital heart disease can lead to life-threatening right ventricular heart failure (RVHF). Results from clinical trials support expanding cardiac progenitor cell (CPC) based therapies. However, our recent data show that CPCs lose function as they age, starting as early as 1 year. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313845DOI Listing
December 2018

Persistent reduction of mitral regurgitation by implantation of a transannular mitral bridge: durability and effectiveness of the repair at 2 years-results of a prospective trial.

Eur J Cardiothorac Surg 2018 Dec 19. Epub 2018 Dec 19.

Heart Repair Technologies, Morgan Hill, CA, USA.

Objectives: Ring annuloplasty reduces the septal-lateral diameter (SLD) indirectly by circumferential annular cinching and frequently results in the recurrence of mitral regurgitation (MR) in patients with functional MR (FMR). Our goal was to report the results from the trial and the 2-year post-trial surveillance data. We evaluated whether direct reduction of the SLD with a transannular mitral bridge could achieve significant and durable MR reduction in patients with FMR. Read More

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https://academic.oup.com/ejcts/advance-article/doi/10.1093/e
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http://dx.doi.org/10.1093/ejcts/ezy423DOI Listing
December 2018
3 Reads

A case of delayed hydrocephalus from cerebrospinal fluid leak after resection of a cervical spinal schwannoma.

Nagoya J Med Sci 2018 Nov;80(4):605-609

Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

A 39-year old man underwent surgery for recurrence of a cervical schwannoma. At 6 months postoperatively, severe headache appeared and head CT showed marked ventricular dilation that was diagnosed as delayed hydrocephalus. Dural repair surgery using a fascia patch of the tensor fasciae latae muscle was performed after VP shunt. Read More

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http://dx.doi.org/10.18999/nagjms.80.4.605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295437PMC
November 2018

Whether Pulmonary Valve Replacement in Asymptomatic Patients With Moderate or Severe Regurgitation After Tetralogy of Fallot Repair Is Appropriate: A Case-Control Study.

J Am Heart Assoc 2019 Jan;8(1):e010689

1 Pediatric Cardiac Surgery Center National Center for Cardiovascular Disease and Fuwai Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing China.

Background Although right ventricular ( RV ) volume was significantly decreased in symptomatic patients with repaired tetralogy of Fallot ( rTOF ) after pulmonary valve replacement ( PVR ), RV size was still enlarged along with RV dysfunction. Methods and Results A prospective case-control study was conducted in a tertiary hospital; 81 asymptomatic repaired tetralogy of Fallot patients with moderate or severe pulmonary regurgitation were enrolled. The enrolled cohort was divided into 2 groups: PVR group (n=41) and medication group (n=40). Read More

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http://dx.doi.org/10.1161/JAHA.118.010689DOI Listing
January 2019
2 Reads

Dysfunctional and Proinflammatory Regulatory T-Lymphocytes Are Essential for Adverse Cardiac Remodeling in Ischemic Cardiomyopathy.

Circulation 2019 Jan;139(2):206-221

Division of Cardiovascular Disease and Comprehensive Cardiovascular Center, University of Alabama at Birmingham (S.S.B., M.A.I., M.G., G.Z., G.R., T.H., S.D.P.).

Background: Heart failure (HF) is a state of inappropriately sustained inflammation, suggesting the loss of normal immunosuppressive mechanisms. Regulatory T-lymphocytes (Tregs) are considered key suppressors of immune responses; however, their role in HF is unknown. We hypothesized that Tregs are dysfunctional in ischemic cardiomyopathy and HF, and they promote immune activation and left ventricular (LV) remodeling. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322956PMC
January 2019
2 Reads

One-Year Outcomes After MitraClip for Functional Mitral Regurgitation.

Circulation 2019 Jan;139(1):37-47

Northshore University Health System, Evanston, IL (P.J.P., T.F.).

Background: Secondary mitral regurgitation (SMR) occurs in the absence of organic mitral valve disease and may develop as the left ventricle dilates or remodels or as a result of leaflet tethering with impaired coaptation, most commonly from apical and lateral distraction of the subvalvular apparatus, with late annular dilatation. The optimal therapy for SMR is unclear. This study sought to evaluate the 1-year adjudicated outcomes of all patients with SMR undergoing the MitraClip procedure in the EVEREST II (Endovascular Valve Edge-to-Edge Repair Study) Investigational Device Exemption program, which is comprised of the randomized clinical trial, the prospective High-Risk Registry, and the REALISM Continued Access Registry (Multicenter Study of the MitraClip System). Read More

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.117.0
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http://dx.doi.org/10.1161/CIRCULATIONAHA.117.031733DOI Listing
January 2019
3 Reads

Long-Term Survival and Echocardiographic Findings After Surgical Ventricular Restoration.

Ann Thorac Surg 2018 Dec 23. Epub 2018 Dec 23.

Department of Cardiac Surgery, University of Michigan-Ann Arbor. Electronic address:

Background: This study investigates the long term survival, and durability of mitral procedures on patients undergoing surgical ventricular restoration (SVR).

Methods: From 1992 to 2017, 109 patients underwent SVR. Survival was determined from hospital records and the National Death Index. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2018.11.054DOI Listing
December 2018

Assessment of Left Ventricular Reverse Remodeling by Cardiac MRI in Patients Undergoing Repair Surgery for Severe Aortic or Mitral Regurgitation.

J Cardiothorac Vasc Anesth 2018 Nov 14. Epub 2018 Nov 14.

Pôle de Recherche Cardiovasculaire (CARD), Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, Brussels, Belgium.

Objective: To evaluate left ventricular (LV) reverse remodeling after repair surgery for mitral regurgitation (MR) or aortic regurgitation (AR), aiming at determining optimal preoperative thresholds for normalization of LV volumes and function after surgery.

Design: Observational prospective cohort study.

Setting: Single-center, academic, tertiary care cardiovascular center. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10530770183103
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http://dx.doi.org/10.1053/j.jvca.2018.11.013DOI Listing
November 2018
5 Reads

Serial pulmonary vascular resistance assessment in patients late after ventricular septal defect repair.

Int J Cardiol 2018 Dec 16. Epub 2018 Dec 16.

Department of Cardiovascular Sciences, KU Leuven, Belgium; Department of Cardiovascular Diseases, University Hospitals Leuven, Belgium. Electronic address:

Background: The long-term evolution of pulmonary vascular resistance (PVR) after ventricular septal defect (VSD) repair is unknown. This study serially evaluated resting and exercise PVR after VSD repair in childhood.

Methods: Patients were enrolled from the outpatient Adult Congenital Heart Disease clinic of the University Hospitals Leuven and compared to age- and gender-matched controls. Read More

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http://dx.doi.org/10.1016/j.ijcard.2018.12.044DOI Listing
December 2018
1 Read