6,027 results match your criteria Ventricular Premature Complexes


"Atrial Fibrillation and Premature Ventricular Complexes" - is there a unifying diagnosis?

J Cardiovasc Electrophysiol 2020 Jun 4. Epub 2020 Jun 4.

Royal Prince Alfred Hospital, Sydney, Australia.

A 64-year-old male presented with a 2-year history of palpitations and light-headedness. Referral for electrophysiological assessment was prompted by a Holter monitoring report of "frequent ventricular ectopic beats (>21,000/24hr) with repetitive runs of atrial fibrillation" (Fig 1). Resting echocardiogram and stress testing were normal. Read More

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http://dx.doi.org/10.1111/jce.14600DOI Listing

An Elusive and Deceptive Tachycardia.

J Innov Card Rhythm Manag 2017 Feb 15;8(2):2626-2627. Epub 2017 Feb 15.

Icahn School of Medicine at Mount Sinai, New York, NY.

A wide-complex tachycardia was induced with rapid atrial pacing, with intermittent ventriculoatrial block and QRS alternans. A short/negative HV interval was observed, and premature ventricular complexes resulted in the termination of the tachycardia. The findings at electrophysiology study were consistent with an antidromic re-entrant tachycardia involving a nodo-fascicular/ventricular connection. Read More

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http://dx.doi.org/10.19102/icrm.2017.080202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252649PMC
February 2017

His bundle pacing: troubleshooting during follow-up.

Herzschrittmacherther Elektrophysiol 2020 May 28. Epub 2020 May 28.

Klinik für Innere Medizin - Kardiologie, Diabetologie & Nephrologie, Evangelisches Klinikum Bethel, Burgsteig 13, 33617, Bielefeld, Germany.

Follow-up of pacemaker systems for His bundle pacing (HBP) requires electrocardiogram (ECG) knowledge and creative thinking. This relates to ventricular threshold measurement in which it can be difficult to distinguish between selective HBP and loss of capture with pseudofusion since, by definition, intrinsic QRS complexes and those selectively paced via the His bundle look identical. Threshold testing in HBP is best performed in unipolar pacing mode, recording of a 12-lead ECG and pacing in VVI mode significantly above the intrinsic rate. Read More

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http://dx.doi.org/10.1007/s00399-020-00693-9DOI Listing

Inhibition of K2 and K11.1 Channels in Pigs With Left Ventricular Dysfunction.

Front Pharmacol 2020 6;11:556. Epub 2020 May 6.

Acesion Pharma, Copenhagen, Denmark.

Background: Inhibition of K2 channels, conducting I, can convert atrial fibrillation (AF) to sinus rhythm and protect against its induction. I inhibition has been shown to possess functional atrial selectivity with minor effects on ventricles. Under pathophysiological conditions with ventricular remodeling, however, inhibiting I can exhibit both proarrhythmic and antiarrhythmic ventricular effects. Read More

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http://dx.doi.org/10.3389/fphar.2020.00556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219273PMC

Prognostic significance of accelerated ventricular response during radiofrequency ablation of premature ventricular complexes.

Indian Pacing Electrophysiol J 2020 May 16. Epub 2020 May 16.

Unit of Cardiac Electrophysiology and Pacing, Department of Cardiology, Christian Medical College, Vellore, India. Electronic address:

Background: Accelerated ventricular response is frequently observed during radiofrequency ablation (RFA) of premature ventricular complexes (PVCs). We hypothesized that acceleration indicates an appropriate site and adequate injury to the arrhythmogenic tissue, and sought to investigate its value in predicting the outcome.

Methods: We retrospectively analyzed RFA procedures performed for PVCs in our institution from 2011 to 2019. Read More

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http://dx.doi.org/10.1016/j.ipej.2020.05.001DOI Listing

Acute effect of outflow tract premature ventricular complex ablation on QT dispersion, Tp-e interval and Tp-e/QT ratio.

Acta Cardiol 2020 May 14:1-5. Epub 2020 May 14.

Department of Cardiology, Marmara University School of Medicine, Istanbul, Turkey.

There is limited data regarding the effect of idiopathic premature ventricular complexes (PVC) on myocardial repolarisation. Most of PVC's originate from right and left ventricular outflow tracts (RVOT and LVOT). The aim of this study is to evaluate the acute effect of outflow tract PVC ablation on electrocardiographic repolarisation markers. Read More

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http://dx.doi.org/10.1080/00015385.2020.1761595DOI Listing
May 2020
0.561 Impact Factor

Novel electrocardiographic criteria for diagnosis of premature ventricular complexes arising from the base of left ventricle.

J Electrocardiol 2020 Apr 23;60:148-150. Epub 2020 Apr 23.

Department of Cardiology, Indiana University School of Medicine, Indianapolis, IN, United States of America; Roudebush Veterans Affairs Medical Center, Indianapolis, IN, United States of America.

Purpose: We report new electrocardiographic criteria (ECG) for localizing premature ventricular complexes (PVCs) originating from the base of the left ventricle (LV).

Methods: QRS deflection (positive negative or negative positive) in lead aVR and aVL respectively, were evaluated in 41 PVC/VT cases.

Results: There were a total of 41 patients, age 64 ± 11 years. Read More

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http://dx.doi.org/10.1016/j.jelectrocard.2020.04.013DOI Listing
April 2020
1.363 Impact Factor

Contact versus non-contact guided ablation of the right ventricular outflow tract arrhythmias: A propensity score matched analysis.

Pacing Clin Electrophysiol 2020 May 3. Epub 2020 May 3.

Division of Cardiology, Section of Pacing and Electrophysiology, Jiangsu Province Hospital and the First Affiliated Hospital with Nanjing Medical University, Nanjing, China.

Background: There are unique advantages and disadvantages in the choice of contact mapping (CM) versus non-contact mapping (NCM) systems during ablation of right ventricular outflow tract (RVOT) arrhythmias. This study compared acute procedural success and clinical outcomes in matched patients undergoing CM versus NCM-guided RVOT ablation.

Methods: 167 consecutive patients with idiopathic RVOT VA underwent NCM or CM-guided ablation. Read More

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http://dx.doi.org/10.1111/pace.13935DOI Listing

Anatomical Approach With Bipolar Ablation Between the Left Pulmonic Cusp and the Left Ventricular Outflow Tract for Left Ventricular Summit Arrhythmias.

Heart Rhythm 2020 Apr 26. Epub 2020 Apr 26.

St. Joseph's Heart Rhythm Center, Rzeszów, Poland; Department of Cardiology, Medical Centre of Postgraduate Education, Grochowski Hospital, Warsaw, Poland.

Background: Radiofrequency ablation (RFA) of ventricular arrhythmias (VAs) arising from the inaccessible basal region of the left ventricular summit (LVS) is challenging due to proximity to coronary vessels, epicardial fat and poor RF delivery within the distal coronary venous system.

Objective: We describe the outcomes of an anatomical approach for inaccessible LVS-VAs using bipolar RF (Bi-RFA) delivered from the anatomically adjacent left pulmonic cusp (LPC) to the opposite LV outflow tract (LVOT).

Methods: From 3 centers we reviewed patients (pts) who underwent Bi-RFA for inaccessible LVS-VAs refractory to conventional RFA using an anatomical approach targeting the adjacent LPC ("reversed U" approach) with catheter tip pointing inferiorly within the LPC and LVOT. Read More

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http://dx.doi.org/10.1016/j.hrthm.2020.04.029DOI Listing

Exercise-Induced Premature Ventricular Contractions Are Associated With Myocardial Ischemia Among Asymptomatic Adult Male Firefighters: Implications for Enhanced Risk Stratification.

Biol Res Nurs 2020 Jul 28;22(3):369-377. Epub 2020 Apr 28.

University of Rochester School of Nursing, NY, USA.

Background: Exercise-induced premature ventricular contractions (EI-PVCs) are associated with an increased risk of cardiovascular disease among asymptomatic adult males, but the underlying mechanisms remain understudied. Myocardial ischemia due to cardiovascular disease reduces coronary blood flow, may impair exercise performance, and initiates EI-PVCs; thus, EI-PVCs may be an early indicator of cardiovascular disease.

Objective: The objective of this study was to determine whether EI-PVCs are associated with myocardial ischemia and reduced exercise performance among asymptomatic adult firefighters. Read More

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http://dx.doi.org/10.1177/1099800420921944DOI Listing

Evaluation and Management of Premature Ventricular Complexes.

Authors:
Gregory M Marcus

Circulation 2020 Apr 27;141(17):1404-1418. Epub 2020 Apr 27.

Electrophysiology Section, Division of Cardiology, University of California, San Francisco.

Premature ventricular complexes (PVCs) are extremely common, found in the majority of individuals undergoing long-term ambulatory monitoring. Increasing age, a taller height, a higher blood pressure, a history of heart disease, performance of less physical activity, and smoking each predict a greater PVC frequency. Although the fundamental causes of PVCs remain largely unknown, potential mechanisms for any given PVC include triggered activity, automaticity, and reentry. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.042434DOI Listing

Risk stratification in patients with nonischemic cardiomyopathy and ventricular arrhythmias based on quantification of intramural delayed enhancement on cardiac magnetic resonance imaging.

J Cardiovasc Electrophysiol 2020 Apr 23. Epub 2020 Apr 23.

Division of Cardiovascular Medicine and Radiology, University of Michigan, Ann Arbor, Michigan.

Introduction: Intramural scarring is a risk factor for sudden cardiac death. The objective of this study was to determine the value of scar quantification for risk stratification in patients with nonischemic cardiomyopathy (NICM) undergoing ablation procedures for ventricular arrhythmias (VA).

Methods And Results: Cardiac late gadolinium-enhanced magnetic resonance imaging was performed in patients with NICM referred for ablation of premature ventricular complexes or ventricular tachycardia (VT). Read More

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http://dx.doi.org/10.1111/jce.14514DOI Listing

Predictors of Ventricular Dysrhythmias in Neurology Intensive Care Unit Patients with Prolonged QTc.

Neurocrit Care 2020 Apr 17. Epub 2020 Apr 17.

Department of Neurology, Section of Neurocritical Care, Wake Forest School of Medicine, Medical Center Blvd, Winston-Salem, NC, 27157, USA.

Introduction: Acute neurological injury and several medications commonly administered in the Neuro ICU pose a risk of fatal cardiac dysrhythmias. The objective of this study is to identify the predictors of ventricular dysrhythmias in the Neuro ICU patients with prolonged QTc, thereby helping the clinicians make important treatment decisions.

Methods: We performed a retrospective review of all consecutive adults admitted to the Neuro ICU from January 2015 to September 2015 with a QTc interval ≥ 450 ms on electrocardiogram. Read More

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http://dx.doi.org/10.1007/s12028-020-00954-yDOI Listing

Ablation at Right Coronary Cusp as an Alternative and Favorable Approach to Eliminate Premature Ventricular Complexes Originating From the Proximal Left Anterior Fascicle.

Circ Arrhythm Electrophysiol 2020 May 17;13(5):e008173. Epub 2020 Apr 17.

Department of Cardiology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, China (S.C., X.L., S.P., G.Z., Z.L., Y.W., K.Y., W.F., L.C., J.X., S.L.).

Background: Premature ventricular complex (PVC) with narrow QRS duration originating from proximal left anterior fascicle (LAF) is challenging for ablation. This study was performed to evaluate the safety and feasibility of ablation from right coronary cusp (RCC) for proximal LAF-PVC and to investigate this PVC's characteristics.

Methods: Mapping at RCC and left ventricle and ECG analysis were performed in 20 patients with LAF-PVC. Read More

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http://dx.doi.org/10.1161/CIRCEP.119.008173DOI Listing

Dietary and Lifestyle Patterns are Associated with Heart Rate Variability.

J Clin Med 2020 Apr 14;9(4). Epub 2020 Apr 14.

Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Via Loredan, 18, 35131 Padova, Italy.

Assessment of heart rate variability (HRV) and cardiac ectopic beats is a clinically relevant topic. The present exploratory observational study aimed to inspect the relationships of lifestyle, dietary patterns, and anthropometrics with HRV, premature ventricular complexes (PVCs), and supraventricular premature complexes (SVPCs). A cross-sectional study enrolling subjects undergoing Holter monitoring was performed. Read More

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http://dx.doi.org/10.3390/jcm9041121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230664PMC

Tp-Te interval and Tp-Te/QT ratio may be predictive of idiopathic ventricular tachycardia in patients with frequent outflow tract premature ventricular complexes.

Acta Cardiol 2020 Apr 14:1-6. Epub 2020 Apr 14.

Kartal Kosuyolu Training and Research Hospital, Cardiology Clinic, Istanbul, Turkey.

The aim of present study is to evaluate the predictive value of QTc dispersion, Tp-Te interval and Tp-Te/QT ratio for idiopathic monomorphic outflow tract ventricular tachycardia (VT) occurrence in patients with frequent idiopathic outflow tract premature ventricular complexes (PVCs). A total of 180 patients (49.2 ± 13. Read More

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http://dx.doi.org/10.1080/00015385.2020.1751958DOI Listing
April 2020
0.561 Impact Factor

Bipolar radiofrequency catheter ablation between the left ventricular endocardium and great cardiac vein for refractory ventricular premature complexes originating from the left ventricular summit.

J Arrhythm 2020 Apr 14;36(2):363-366. Epub 2020 Feb 14.

Department of Cardiology Tokyo Metropolitan Hiroo Hospital Tokyo Japan.

Ablation for ventricular arrhythmias originating from the left ventricular (LV) summit is sometimes challenging. Bipolar radiofrequency catheter ablation (RFCA) is effective for refractory arrhythmias; little is known about bipolar RFCA from the coronary venous system and the appropriate settings. We experienced three cases of ventricular premature complexes (VPCs) originating from the LV summit successfully treated by bipolar RFCA between the LV endocardium (irrigated catheters as active electrodes) and coronary venous system (8-mm-tip catheters as return electrodes). Read More

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http://dx.doi.org/10.1002/joa3.12312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132175PMC

Clinical Significance of Statistical Differences.

Arq Bras Cardiol 2020 02;114(2):281-283

Hospital dos Servidores do Estado, Cardiologia, Rio de Janeiro, RJ - Brazil.

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http://dx.doi.org/10.36660/abc.20200006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7077560PMC
February 2020

Noninvasive localization of cardiac arrhythmias using electromechanical wave imaging.

Sci Transl Med 2020 Mar;12(536)

Division of Cardiology, Department of Medicine and Vagelos College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

Cardiac arrhythmias are a major cause of morbidity and mortality worldwide. The 12-lead electrocardiogram (ECG) is the current noninvasive clinical tool used to diagnose and localize cardiac arrhythmias. However, it has limited accuracy and is subject to operator bias. Read More

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http://dx.doi.org/10.1126/scitranslmed.aax6111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7234276PMC

Anxiety is associated with increased risk for atrial cardiopathy.

Acta Neurol Belg 2020 Mar 19. Epub 2020 Mar 19.

Division of Neurology, Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Guangzhou Road 300#, Nanjing, China.

Anxiety is common in patients with atrial fibrillation (AF). The mutual causal effect between anxiety and AF is expected with limited evidence. Atrial cardiopathy is a term to describe structural or electrophysiological atrium abnormality that precedes the onset of AF. Read More

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http://dx.doi.org/10.1007/s13760-020-01335-0DOI Listing

Catheter cryoablation of ventricular ectopy originating from his region.

Clin Case Rep 2020 Mar 5;8(3):487-490. Epub 2020 Feb 5.

The Arrhythmology Unit Department of Invasive Cardiology Fondazione "Gabriele Monasterio" CNR-Regione Toscana Pisa Italy.

Careful mapping, early detection of AV conduction damage and cryothermal energy availability are essential in dealing with ablation procedures at the parahisian region. Read More

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http://dx.doi.org/10.1002/ccr3.2649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069889PMC

Premature ventricular contraction detection for long-term monitoring in an implantable cardiac monitor.

Pacing Clin Electrophysiol 2020 May 10;43(5):462-470. Epub 2020 Apr 10.

Medtronic Inc, Mounds View, Minnesota.

Background: Premature ventricular complexes (PVCs) are an important therapeutic target in symptomatic patients and in the setting of PVC-induced cardiomyopathy; however, measuring burden and therapeutic response is challenging. We developed and validated an algorithm for continuous long-term monitoring of PVC burden in an insertable cardiac monitor (ICM).

Methods: A high-specificity PVC detection algorithm was developed using real-world ICM data and validated using simultaneous Holter data and real-world ICM data. Read More

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http://dx.doi.org/10.1111/pace.13903DOI Listing

Electrocardiographic characteristics for successful radiofrequency ablation of right coronary cusp premature ventricular contractions.

Medicine (Baltimore) 2020 Mar;99(11):e19398

Division of Cardiology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan university School of Medicine, Seoul, Republic of Korea.

Electrocardiographic (ECG) criteria identifying right- and left-sided outflow tract origins have been established. The purpose of this study was to define the criteria for premature ventricular contractions (PVCs) originating from the right coronary cusp (RCC) adequately.We analyzed ECG and electrophysiologic study data from patients who underwent successful ablation of PVCs originating from the RCC and right ventricular outflow tract (RVOT). Read More

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http://dx.doi.org/10.1097/MD.0000000000019398DOI Listing
March 2020
5.723 Impact Factor

Bepridil Inhibits Premature Ventricular Complexes Induced by Cardio-Sympathetic Nerve Stimulation in a Canine Experimental Model.

Int Heart J 2020 Mar 14;61(2):338-346. Epub 2020 Mar 14.

Cardiovascular Research, Graduate School of Health Sciences, Niigata University School of Medicine.

Sympathetic nerve activity has arrhythmogenic potential for ventricular arrhythmias associated with structural heart diseases. However, a sufficient amount of beta-blockers occasionally cannot be prescribed in some patients.An experimental study was performed to clarify the therapeutic effects of bepridil, a multiple ionic current inhibitor that does not affect beta-adrenergic receptors, for premature beats occurring during enhanced sympathetic nerve activity. Read More

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http://dx.doi.org/10.1536/ihj.19-494DOI Listing

Acute, subacute and chronic sequelae of horses accidentally exposed to monensin-contaminated feed.

Equine Vet J 2020 Mar 7. Epub 2020 Mar 7.

Department of Clinical Sciences, Faculty of Veterinary Medicine, Université de Montréal, St-Hyacinthe, Quebec, Canada.

Background: Monensin is highly toxic to horses and inadvertent ingestion can result in cardiac injury and death.

Objectives: To describe sequelae of monensin ingestion and to determine clinical predictors of outcome.

Study Design: Observational clinical study. Read More

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http://dx.doi.org/10.1111/evj.13258DOI Listing

Ventricular Arrhythmias in Myocarditis: Characterization and Relationships With Myocardial Inflammation.

J Am Coll Cardiol 2020 Mar;75(9):1046-1057

Department of Cardiac Electrophysiology and Arrhythmology, IRCCS San Raffaele Hospital and Vita-Salute University, Milan, Italy.

Background: Ventricular arrhythmias (VAs) have never been systematically investigated in patients with myocarditis at different stages.

Objectives: The purpose of this study was to compare baseline and follow-up characteristics of VAs in patients with active myocarditis (AM) versus previous myocarditis (PM).

Methods: A total of 185 consecutive patients (69% males, age 44 ± 15 years, left ventricular ejection fraction 49 ± 14%) with myocarditis and VA at index hospitalization, including ventricular fibrillation, ventricular tachycardia (VT), nonsustained ventricular tachycardia (NSVT), and Lown's grade ≥2 premature ventricular complexes, were enrolled. Read More

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http://dx.doi.org/10.1016/j.jacc.2020.01.036DOI Listing

Outflow-tract ventricular tachycardia: Can 12 lead ECG during sinus rhythm identify underlying cardiac sarcoidosis?

Indian Pacing Electrophysiol J 2020 May - Jun;20(3):83-90. Epub 2020 Feb 29.

Dept of Electrophysiology, Care Hospitals, Hyderabad, India. Electronic address:

Background: Patients with outflow tract ventricular tachycardia (OTVT) with normal echocardiogram are labeled as idiopathic VT (IVT). However, a subset of these patients is subsequently diagnosed with underlying cardiac sarcoidosis (CS).

Objective: Whether electrocardiogram (ECG) abnormalities in sinus rhythm (SR) can differentiate underlying CS from IVT. Read More

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http://dx.doi.org/10.1016/j.ipej.2020.02.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244880PMC
February 2020

Approach to induce infrequent premature ventricular complexes.

Pacing Clin Electrophysiol 2020 May 8;43(5):435-436. Epub 2020 May 8.

Department of Internal Medicine, Division of Cardiology, American University of Beirut Medical Center, Beirut, Lebanon.

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http://dx.doi.org/10.1111/pace.13892DOI Listing

Predictors of adverse outcome in patients with frequent premature ventricular complexes: The ABC-VT risk score.

Heart Rhythm 2020 Feb 26. Epub 2020 Feb 26.

Division of Cardiology, University of California San Francisco, San Francisco, California. Electronic address:

Background: No independently validated score currently exists for risk stratification of patients with frequent premature ventricular contractions (PVCs).

Objectives: The purpose of this study was to develop a risk score to predict adverse events in patients with frequent PVCs.

Methods: We analyzed consecutive patients between 2012 and 2017 undergoing 14-day continuous monitoring with frequent PVCs (>5%) and concurrent echocardiography. Read More

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http://dx.doi.org/10.1016/j.hrthm.2020.02.020DOI Listing
February 2020

Comparison of single- versus seven-day Holter analysis for the identification of dilated cardiomyopathy predictive criteria in apparently healthy Doberman Pinscher dogs.

J Vet Cardiol 2020 Feb 4;27:78-87. Epub 2020 Feb 4.

Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Veterinary Medical Center, 736 Wilson Rd, East Lansing, MI, 48824, USA. Electronic address:

Introduction: The primary objective of this study was to test whether seven-day Holter recording improves the sensitivity of detecting dilated cardiomyopathy (DCM) predictive criteria (DCM) compared with 24-h Holter recording in asymptomatic Doberman Pinscher (DP) dogs.

Animals: Twenty-eight asymptomatic DP dogs with normal echocardiographic examinations.

Methods: Dogs with normal echocardiographic examinations underwent seven-day Holter monitoring. Read More

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http://dx.doi.org/10.1016/j.jvc.2020.01.003DOI Listing
February 2020

Unique features of epicardial ventricular arrhythmias/premature ventricular complexes ablated from coronary venous system in veteran population.

Indian Pacing Electrophysiol J 2020 May - Jun;20(3):97-104. Epub 2020 Feb 18.

Department of Cardiology, Indiana University School of Medicine, Indianapolis, IN, USA; Roudebush Veterans Affairs Medical Center, Indianapolis, IN, USA.

Introduction: Ventricular arrhythmias/premature ventricular complexes (VA/PVCs) that can be ablated from within the coronary venous system (CVS) have not been described in the United States Veterans Health Administration (VHA) population. We retrospectively studied the VA/PVCs ablations that were performed in the VHA population.

Methods: Data from 42 consecutive patients who underwent VA/PVCs ablation at Veterans Affairs Hospital, Indianapolis, IN, with 44 VA/PVCs was included in the study. Read More

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http://dx.doi.org/10.1016/j.ipej.2020.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244881PMC
February 2020

Effectiveness of Implanted Cardiac Rhythm Recorders With Electrocardiographic Monitoring for Detecting Arrhythmias in Pregnant Women With Symptomatic Arrhythmia and/or Structural Heart Disease: A Randomized Clinical Trial.

JAMA Cardiol 2020 Feb 19. Epub 2020 Feb 19.

Division of Cardiology, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa.

Importance: Arrhythmias are an important cause of maternal morbidity and mortality but remain difficult to diagnose.

Objective: To compare implantable loop recorder (ILR) plus 24-hour Holter electrocardiographic (ECG) monitoring with standard 24-hour Holter ECG monitoring alone in terms of acceptability, ability to identify significant arrythmias, and effect on management and pregnancy outcome in women who were symptomatic or at high risk of arrythmia because of underlying structural heart disease.

Design, Setting, And Participants: This single-center, prospective randomized clinical trial recruited 40 consecutive patients from the Cardiac Disease and Maternity Clinic at Groote Schuur Hospital in Cape Town, South Africa. Read More

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http://dx.doi.org/10.1001/jamacardio.2019.5963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042843PMC
February 2020

Prognostic significance of premature ventricular complex burden on hospitalized patients with heart failure.

J Arrhythm 2020 Feb 11;36(1):134-142. Epub 2019 Nov 11.

Department of Cardiovascular Medicine Fukushima Medical University Fukushima Japan.

Background: The clinical significance of premature ventricular complexes (PVCs) in heart failure (HF) remains unclear. We aimed to clarify the associations of PVC burden with re-hospitalization and cardiac death in HF patients.

Methods: We studied 435 HF patients (271 men, mean age 65 years). Read More

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http://dx.doi.org/10.1002/joa3.12259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011850PMC
February 2020

2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias: Executive summary.

J Arrhythm 2020 Feb 3;36(1):1-58. Epub 2020 Jan 3.

Leiden University Medical Center Leiden The Netherlands.

Ventricular arrhythmias are an important cause of morbidity and mortality and come in a variety of forms, from single premature ventricular complexes to sustained ventricular tachycardia and fibrillation. Rapid developments have taken place over the past decade in our understanding of these arrhythmias and in our ability to diagnose and treat them. The field of catheter ablation has progressed with the development of new methods and tools, and with the publication of large clinical trials. Read More

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http://dx.doi.org/10.1002/joa3.12264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011820PMC
February 2020

Night-Time Premature Ventricular Complex Positively Correlates With Cardiac Sympathetic Activity in Patients Undergoing Radiofrequency Catheter Ablation.

Heart Lung Circ 2019 Dec 3. Epub 2019 Dec 3.

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China; Cardiovascular Research Institute, Wuhan University, Wuhan 430060, PR China; Hubei Key Laboratory of Cardiology, Wuhan 430060, PR China. Electronic address:

Background: Patients with premature ventricular complexes (PVCs) usually experience accompanying alterations of the autonomic nerve system. The timing of PVC occurrence is associated with different circadian rhythms, which may be related to the autonomic nerve imbalance. The relationship between night-time PVC and cardiac autonomic nervous activity is still obscure. Read More

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http://dx.doi.org/10.1016/j.hlc.2019.11.009DOI Listing
December 2019

The Electrocardiographic Footprints of Ventricular Ectopy.

Heart Lung Circ 2020 Jan 30. Epub 2020 Jan 30.

Department of Cardiology, Prince Charles Hospital and Faculty of Medicine, University of Queensland, Brisbane, Qld, Australia.

Ventricular ectopics, also known as ventricular extrasystoles, premature ventricular contractions or complexes (PVC) and ventricular premature depolarisations (VPD) are beats arising from within the ventricles. When they occur in groupings such as bigeminy, trigeminy, couplets and triplets they are referred to as ventricular ectopy. The electrocardiographic (ECG) footprints of a ventricular ectopic include a broad (>110 ms), premature, ventricular complex (QRS deflection); no evidence of pure atrioventricular (AV) conduction; a full, more than, or less than compensatory pause; and discordant QRS and T wave axis. Read More

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http://dx.doi.org/10.1016/j.hlc.2020.01.002DOI Listing
January 2020

The Ubiquitous Premature Ventricular Complex.

Cureus 2020 Jan 7;12(1):e6585. Epub 2020 Jan 7.

Internal Medicine: Cardiology, Southern Illinois University School of Medicine, Springfield, USA.

Premature ventricular complexes (PVCs) are one of the most commonly encountered arrhythmias and are ubiquitous in clinical practice, both in the outpatient and inpatient settings. They are often discovered incidentally in asymptomatic patients, however, can cause myriad symptoms acutely and chronically. Long thought to be completely benign, PVCs have been historically disregarded without pursuing any further evaluation. Read More

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http://dx.doi.org/10.7759/cureus.6585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001138PMC
January 2020

Catheter ablation of premature ventricular complexes associated with false tendons: A case report.

World J Clin Cases 2020 Jan;8(2):325-330

Center for Cardiac Arrhythmia, Fuwai Hospital, National Center for Cardiovascular Diseases, State Key Laboratory of China, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.

Background: False tendon is a common intraventricular anatomical variation. It refers to a fibroid or fibromuscular structure that exists in the ventricle besides the normal connection of papillary muscle and mitral or tricuspid valve. A large number of clinical studies have suggested that there is a significant correlation between false tendons and premature ventricular complexes. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i2.325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000933PMC
January 2020

Successful treatment of cardiac dysrhythmia associated with foot and mouth disease in a calf.

Iran J Vet Res 2019 ;20(4):304-307

FMD Research Laboratory, Indian Veterinary Research Institute, Regional Campus, Hebbal, Bengaluru-560024, India.

Background: Foot and mouth disease (FMD), which causes myocarditis, results in 50% sudden death in the suckling calves. Occurrence of arrhythmias associated with FMD induced myocarditis in calves is not reported . ‏‏‏The present work documents the arrhythmias associated with FMD in calf and their treatment using appropriate antiarrhythmic drugs. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983308PMC
January 2019

The Hyperpolarization-Activated Cyclic-Nucleotide-Gated Channel Blocker Ivabradine Does Not Prevent Arrhythmias in Catecholaminergic Polymorphic Ventricular Tachycardia.

Front Pharmacol 2019 17;10:1566. Epub 2020 Jan 17.

Department of Physiology and Pharmacology, The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited, stressed-provoked ventricular arrhythmia. CPVT is treated by β-adrenergic receptor blockers, Na channel inhibitors, sympathetic denervation, or by implanting a defibrillator. We showed recently that blockers of SK4 Ca-activated K channels depolarize the maximal diastolic potential, reduce the heart rate, and attenuate ventricular arrhythmias in CPVT. Read More

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http://dx.doi.org/10.3389/fphar.2019.01566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978284PMC
January 2020

A Novel Loss-of-Function Variant in the Chloride Ion Channel Gene Clcn2 Associates with Atrial Fibrillation.

Sci Rep 2020 Jan 29;10(1):1453. Epub 2020 Jan 29.

Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Atrial Fibrillation (AF) is the most common cardiac arrhythmia. Its pathogenesis is complex and poorly understood. Whole exome sequencing of Danish families with AF revealed a novel four nucleotide deletion c. Read More

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http://dx.doi.org/10.1038/s41598-020-58475-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989500PMC
January 2020

2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias: executive summary.

Europace 2020 Mar;22(3):450-495

Leiden University Medical Center, Leiden, the Netherlands.

Ventricular arrhythmias are an important cause of morbidity and mortality and come in a variety of forms, from single premature ventricular complexes to sustained ventricular tachycardia and fibrillation. Rapid developments have taken place over the past decade in our understanding of these arrhythmias and in our ability to diagnose and treat them. The field of catheter ablation has progressed with the development of new methods and tools, and with the publication of large clinical trials. Read More

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http://dx.doi.org/10.1093/europace/euz332DOI Listing

2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias.

J Interv Card Electrophysiol 2020 Jan 27. Epub 2020 Jan 27.

Leiden University Medical Center, Leiden, the Netherlands.

Ventricular arrhythmias are an important cause of morbidity and mortality and come in a variety of forms, from single premature ventricular complexes to sustained ventricular tachycardia and fibrillation. Rapid developments have taken place over the past decade in our understanding of these arrhythmias and in our ability to diagnose and treat them. The field of catheter ablation has progressed with the development of new methods and tools, and with the publication of large clinical trials. Read More

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http://dx.doi.org/10.1007/s10840-019-00663-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223859PMC
January 2020

Catheter Ablation for Brugada Syndrome.

Korean Circ J 2020 Apr 3;50(4):289-301. Epub 2019 Dec 3.

Department of Cardiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

Brugada syndrome (BrS) is an arrhythmogenic disease associated with an increased risk of ventricular fibrillation (VF) and sudden cardiac death (SCD). To date, the standard therapy for the prevention of SCD in BrS is the use of an implantable cardioverter-defibrillator (ICD) especially in patients who have experienced a prior cardiac arrest or syncopal events secondary to VF. However, ICDs do not prevent the occurrence of VF but react to defibrillate the VF episode, thereby preventing SCD. Read More

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http://dx.doi.org/10.4070/kcj.2019.0344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067603PMC

2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias: Executive summary.

J Interv Card Electrophysiol 2020 Jan 20. Epub 2020 Jan 20.

Leiden University Medical Center, Leiden, the Netherlands.

Ventricular arrhythmias are an important cause of morbidity and mortality and come in a variety of forms, from single premature ventricular complexes to sustained ventricular tachycardia and fibrillation. Rapid developments have taken place over the past decade in our understanding of these arrhythmias and in our ability to diagnose and treat them. The field of catheter ablation has progressed with the development of new methods and tools, and with the publication of large clinical trials. Read More

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http://dx.doi.org/10.1007/s10840-019-00664-2DOI Listing
January 2020

Smartwatch PPG Peak Detection Method for Sinus Rhythm and Cardiac Arrhythmia.

Conf Proc IEEE Eng Med Biol Soc 2019 07;2019:4310-4313

The aim of our work herein was to design a photoplethysmographic (PPG) peak detection algorithm which automatically detect and discriminate various cardiac rhythms-normal sinus rhythms (NSR), premature atrial contraction (PAC), premature ventricle contraction (PVC), and atrial fibrillation (AF)-for PPG signals collected on smartwatch. Compared with peak detection algorithm designed for NSR, the novelty is that our proposed peak detection algorithm can accurately estimate heart rates (HR) among various arrhythmias, which enhances the accuracy of AF screening. Our peak detection method is composed of a sequential series of algorithms that are combined to discriminate various arrhythmias, as described above. Read More

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http://dx.doi.org/10.1109/EMBC.2019.8857325DOI Listing

Influence of baseline QRS on the left ventricular ejection fraction recovery after frequent premature ventricular complex ablation.

Europace 2020 Feb;22(2):274-280

Heart Institute, Teknon Medical Center, Barcelona, Spain.

Aims: Frequent premature ventricular complexes (PVCs) can induce or worsen left ventricular systolic dysfunction. We aimed to investigate the influence of the baseline QRS in the response after PVC ablation in patients with depressed left ventricular ejection fraction (LVEF).

Methods And Results: Two hundred and fifteen [59 ± 13 years old, 152 (71%) men] consecutive patients with left ventricular (LV) systolic dysfunction and frequent PVCs referred for ablation were included and followed-up for 12 months. Read More

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http://dx.doi.org/10.1093/europace/euz330DOI Listing
February 2020

A novel gain-of-function mutation in SCN5A responsible for multifocal ectopic Purkinje-related premature contractions.

Hum Mutat 2020 Apr 25;41(4):850-859. Epub 2020 Jan 25.

Faculté de Médecine, Sorbonne Université, Paris, France.

Recently, four SCN5A mutations have been associated with Multifocal Ectopic Purkinje-related Premature Contractions (MEPPC), a rare cardiac syndrome combining polymorphic ventricular arrhythmia with dilated cardiomyopathy (DCM). Here, we identified a novel heterozygous mutation in SCN5A (c.611C>A, pAla204Glu) in a young woman presenting with polymorphic premature ventricular contractions (PVCs) and DCM. Read More

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http://dx.doi.org/10.1002/humu.23981DOI Listing