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    Isolated Right Ventricular Apical Trabecular Hypoplasia: A Case Report.
    J Heart Valve Dis 2017 Jan;26(1):107-110
    Department of Cardiac Surgery, Shandong Provincial Hospital, Affiliated Hospital of Shandong University, Jinan, China. Electronic correspondence:
    Right ventricular (RV) hypoplasia with isolated myocardial disease and complete absence of RV trabeculae is a rare congenital heart disease, the current treatment of which is ineffective. Here, a rare case is presented of a middle-aged female patient with RV hypoplasia complicated by tricuspid regurgitation, right atrial thrombus, and atrial fibrillation. The patient was treated with a one-and-a-half ventricular repair, and showed significant improvements in cardiac function and physical activity tolerance. Read More

    Permanent nonselective His bundle pacing in an adult with L-transposition of the great arteries and complete AV block.
    Pacing Clin Electrophysiol 2017 May 24. Epub 2017 May 24.
    Indiana University, Director, Atrial Fibrillation Program, Krannert Institute of Cardiology, Indiana University Health Physicians.
    We report the placement of a permanent transvenous nonselective His bundle pacing lead in conjunction with a transvenous pacemaker/ICD in an adult with Levo-Transposition of the Great Arteries (L-TGA) and a stenotic coronary sinus (CS) ostium (os), which would not accommodate a transvenous LV pacing lead. Nonselective His bundle pacing provided a nearly identical ventricular activation pattern in this previously unpaced patient. Many L-TGA patients will have an eventual need for permanent pacing and, given the challenges of CS cannulation, His bundle pacing may represent a preferred modality rather than pure morphologic LV pacing or surgical systemic ventricular lead placement to achieve optimal electrical synchrony. Read More

    Right ventricular pacemaker lead position is associated with differences in long-term outcomes and complications.
    J Cardiovasc Electrophysiol 2017 May 24. Epub 2017 May 24.
    Department of Cardiovascular Diseases.
    Introduction: Cardiac pacing from the right ventricular apex is associated with detrimental long-term effects and non-apical pacing locations may be associated with improved outcomes. There is little data regarding complications with non-apical lead positions. The aim of this study was to assess long-term outcomes and lead-related complications associated with differing ventricular lead tip position. Read More

    Stricter criteria for left bundle branch block diagnosis do not improve response to CRT.
    Pacing Clin Electrophysiol 2017 May 23. Epub 2017 May 23.
    Mediterranean Clinic, Naples, Italy.
    Background: Cardiac resynchronization therapy (CRT) has proved to be effective in patients with heart failure and left bundle branch block (LBBB). Recently, new ECG criteria have been proposed for the diagnosis of LBBB. These criteria are stricter than the current American Heart Association (AHA) criteria. Read More

    "Real life" longevity of implantable cardioverter-defibrillator devices.
    Clin Cardiol 2017 May 22. Epub 2017 May 22.
    Third Department of Cardiology, Hippokratio Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
    Background: Manufacturers of implantable cardioverter-defibrillators (ICDs) promise a 5- to 9-year projected longevity; however, real-life data indicate otherwise. The aim of the present study was to assess ICD longevity among 685 consecutive patients over the last 20 years.

    Hypothesis: Real-life longevity of ICDs may differ from that stated by the manufacturers. Read More

    The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in dedicated goat and dog models.
    Br J Pharmacol 2017 May 24. Epub 2017 May 24.
    Department of Medical Physiology, University Medical Center Utrecht, The Netherlands.
    Background And Purpose: Inward rectifier current (IK1 ) density increases in atrial fibrillation (AF), shortening effective refractory period and thus promotes atrial reentry. Pentamidine-Analogue 6 (PA-6) is a selective and potent IK1 inhibitor. We tested PA-6 for anti-AF efficacy and potential proarrhythmia, in established large animal models. Read More

    The IK1/Kir2.1 channel agonist zacopride prevents and cures acute ischemic arrhythmias in the rat.
    PLoS One 2017 18;12(5):e0177600. Epub 2017 May 18.
    Department of Pathophysiology, Shanxi Medical University, Taiyuan, China.
    Arrhythmogenesis in acute myocardial infarction (MI) is associated with depolarization of resting membraine potential (RMP) and decrease of inward rectifier potassium current (IK1) in cardiomyocytes. However, clinical anti-arrhythmic agents that primarily act on RMP by enhancing the IK1 channel are not currently available. We hypothesized that zacopride, a selective and moderate agonist of the IK1/Kir2. Read More

    Improvement of left ventricular diastolic function and left heart morphology in young women with morbid obesity six months after bariatric surgery.
    Cardiol J 2017 May 25. Epub 2017 May 25.
    Department of Internal Medicine and Cardiology, Medical University of Warsaw, Poland.
    Background: Obesity contributes to left ventricular diastolic dysfunction (LVDD) and may lead to diastolic heart failure. Weight loss (WL) after bariatric surgery (BS) may influence LV morphology and function. Using echocardiography, this study assessed the effect of WL on LV diastolic function (LVDF) and LV and left atrium (LA) morphology 6 months after BS in young women with morbid obesity. Read More

    Hypertension and Cardiac Arrhythmias: Executive Summary of a Consensus Document from the European Heart Rhythm Association (EHRA) and ESC Council on Hypertension, endorsed by the Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS) and Sociedad Latinoamericana de Estimulación Cardíaca y Electrofisiología (SOLEACE).
    Eur Heart J Cardiovasc Pharmacother 2017 May 25. Epub 2017 May 25.
    Institute of Cardiovascular Science, University College London, UK University College London, UK.
    Hypertension (HTN) is a common cardiovascular risk factor leading to heart failure (HF), coronary artery disease (CAD), stroke, peripheral artery disease and chronic renal failure. Hypertensive heart disease can manifest as many types of cardiac arrhythmias, most commonly being atrial fibrillation (AF). Both supraventricular and ventricular arrhythmias may occur in HTN patients, especially in those with left ventricular hypertrophy (LVH), CAD or HF. Read More

    Progressive increase of the Tpeak-Tend interval is associated with ischaemia-induced ventricular fibrillation in a porcine myocardial infarction model.
    Europace 2017 May 24. Epub 2017 May 24.
    Department of Cardiology, Clinical Sciences, Lund University, SE-221 85, Lund, Sweden.
    Aims: Repolarization indices of ECG have been widely assessed as predictors of ventricular arrhythmias. However, little is known of the dynamic changes of these parameters during continuous monitoring in acute ischaemic episodes. The objective of the study was to evaluate repolarization-related predictors of ventricular fibrillation (VF) during progression of experimental myocardial infarction. Read More

    Systemic Inflammation and Arrhythmogenesis: A Review of Mechanistic and Clinical Perspectives.
    Angiology 2017 Jan 1:3319717709380. Epub 2017 Jan 1.
    2 Cardiology Department, Trakya Üniversity, Edirne, Turkey.
    In the recent decades, systemic inflammation, as a clinical phenomenon, has been the focus of extensive research particularly with regard to its potential association with a variety of cardiovascular diseases including atherogenesis and acute coronary syndromes. Within this context, there also exists a potential link between systemic inflammation and cardiac arrhythmogenesis in various aspects. Accordingly, systemic inflammation response as measured with inflammation markers (cytokines, etc) has been investigated in the setting of well-known cardiac arrhythmias including atrial fibrillation and ventricular tachycardia. Read More

    Actual management and prognosis of severe isolated tricuspid regurgitation associated with atrial fibrillation without structural heart disease.
    Int J Cardiol 2017 May 11. Epub 2017 May 11.
    Department of Cardiology, Tenri Hospital, Tenri-City, Nara, Japan.
    Background: Patients with atrial fibrillation (AF) without structural heart diseases can show severe tricuspid regurgitation (TR), especially among aged people. The aim of this study was to clarify the actual management, prognosis, and prognostic factors for severe isolated TR associated with AF without structural heart diseases.

    Methods And Results: We retrospectively investigated actual management in 178 consecutive patients with severe isolated TR associated with AF between 1999 and 2011 in our institution. Read More

    Clinical implications of hypothermic ventricular fibrillation versus beating-heart technique during cardiopulmonary bypass for pulmonary valve replacement in patients with repaired tetralogy of Fallot.
    Interact Cardiovasc Thorac Surg 2017 May 23. Epub 2017 May 23.
    Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Jongnogu, Seoul, Republic of Korea.
    Objectives: This study aimed to compare the effects of hypothermic ventricular fibrillation and beating-heart techniques during cardiopulmonary bypass (CPB) on postoperative outcomes after simple pulmonary valve replacement in patients with repaired tetralogy of Fallot (TOF).

    Methods: We retrospectively reviewed the data of 47 patients with repaired tetralogy of Fallot at a single institution, who received pulmonary valve replacement under the ventricular fibrillation or beating-heart technique without cardioplegic cardiac arrest during CPB between January 2005 and April 2015.

    Results: The patients were divided into fibrillation ( n  = 32) and beating-heart ( n  = 15) groups. Read More

    [Ventricular arrhythmias in ion channel diseases].
    Herzschrittmacherther Elektrophysiol 2017 May 22. Epub 2017 May 22.
    Medizinische Klinik für Kardiologie, Nephrologie und Internistische Intensivmedizin, Klinikum Ludwigsburg, Posilipostrasse 4, 71640, Ludwigsburg, Deutschland.
    In patients with ion channel disease the predominant arrhythmias are polymorphic ventricular tachycardias (VT), torsade de pointes tachycardia and ventricular fibrillation (VF). In only extremely rare cases is very rapid monomorphic ventricular tachycardia observed. This is why implantable cardioverter-defibrillators (ICDs) should always be programmed for treatment of VF only with high detection rates to avoid inappropriate discharges. Read More

    Correlation of Ventricular Arrhythmogenesis with Neuronal Remodeling of Cardiac Postganglionic Parasympathetic Neurons in the Late Stage of Heart Failure after Myocardial Infarction.
    Front Neurosci 2017 8;11:252. Epub 2017 May 8.
    Department of Emergency Medicine, University of Nebraska Medical CenterOmaha, NE, USA.
    Introduction: Ventricular arrhythmia is a major cause of sudden cardiac death in patients with chronic heart failure (CHF). Our recent study demonstrates that N-type Ca(2+) currents in intracardiac ganglionic neurons are reduced in the late stage of CHF rats. Rat intracardiac ganglia are divided into the atrioventricular ganglion (AVG) and sinoatrial ganglion. Read More

    The role of genetics in primary ventricular fibrillation, inherited channelopathies and cardiomyopathies.
    Int J Cardiol 2017 Jun;237:45-48
    IRCCS Istituto Auxologico Italiano, Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics, Milan, Italy; Department of Molecular Medicine, University of Pavia, Italy.
    Sudden cardiac death (SCD) has a strong familial component; however, our understanding of its genetic basis varies significantly according to the underlying causes. When coronary artery disease is involved, the predisposing genetic background is complex and despite some interesting findings it remains largely unknown. Quite different is the case of monogenic structural and non-structural heart diseases, in which a number of disease-causing genes have been established and are being used in clinical practice. Read More

    C-GRApH: A Validated Scoring System for Early Stratification of Neurologic Outcome After Out-of-Hospital Cardiac Arrest Treated With Targeted Temperature Management.
    J Am Heart Assoc 2017 May 20;6(5). Epub 2017 May 20.
    Department of Cardiovascular Medicine, University of Virginia, Charlottesville, VA
    Background: Out-of-hospital cardiac arrest (OHCA) results in significant morbidity and mortality, primarily from neurologic injury. Predicting neurologic outcome early post-OHCA remains difficult in patients receiving targeted temperature management.

    Methods And Results: Retrospective analysis was performed on consecutive OHCA patients receiving targeted temperature management (32-34°C) for 24 hours at a tertiary-care center from 2008 to 2012 (development cohort, n=122). Read More

    Drug-induced Fatal Arrhythmias: Acquired long QT and Brugada Syndromes.
    Pharmacol Ther 2017 May 17. Epub 2017 May 17.
    Department of Cardiovascular and Respiratory Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan. Electronic address:
    Since the early 1990s, the concept of primary "inherited" arrhythmia syndromes or ion channelopathies has evolved rapidly as a result of revolutionary progresses made in molecular genetics. Alterations in genes coding for membrane proteins such as ion channels or their associated proteins responsible for the generation of cardiac action potentials (AP) have been shown to cause specific malfunctions which eventually lead to cardiac arrhythmias. These arrhythmic disorders include congenital long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, short QT syndrome, progressive cardiac conduction disease, etc. Read More

    Mechanism of atrial functional mitral regurgitation in patients with atrial fibrillation: A study using three-dimensional transesophageal echocardiography.
    J Cardiol 2017 May 17. Epub 2017 May 17.
    Department of Cardiology, Nishinomiya-Watanabe Cardiovascular Center, Nishinomiya, Japan.
    Background: Functional mitral regurgitation (MR) can occur in patients with atrial fibrillation (AF) despite having preserved left ventricular (LV) systolic function. This MR is known as atrial functional MR. The aim of this study was to clarify the mechanism of atrial functional MR using real-time three-dimensional transesophageal echocardiography (3DTEE). Read More

    Energy Drinks and atrial fibrillation in young adults.
    Clin Nutr 2017 May 6. Epub 2017 May 6.
    Section of Surgery, University of Modena and Reggio Emilia, Modena, Italy.
    The present paper evaluates the association between Energy Drinks (EDs) and occurrence of atrial fibrillation (AF) in young people. Data from three clinical cases of AF after EDs consumption are reported. All patients presented with palpitations, nausea and anxiety. Read More

    Genetic variants of interleukin-18 are associated with reduced risk of atrial fibrillation in a population from Northeast China.
    Gene 2017 May 16. Epub 2017 May 16.
    Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang, China. Electronic address:
    Atrial fibrillation (AF) affects approximately 1-2% of general population. Chronic inflammation plays an important role in AF development and interleukin-18 (IL-18) is a pro-inflammatory cytokine. This study aimed to assess the association of single nucleotide polymorphisms (SNPs) of IL-18 for with AF risk. Read More

    Slow ventricular tachycardia in a 91-year-old man with implantable cardioverter-defibrillator and acute respiratory failure.
    Am J Emerg Med 2017 May 11. Epub 2017 May 11.
    Cardiology and Coronary Intensive Care Unit, "San Giuseppe Moscati" Hospital, via Contrada Amoretta, 83100 Avellino, Italy.
    Slow ventricular tachycardia (VT) in patients with devices such as an implantable cardioverter - defibrillator (ICD) is more common than in the rest of the population. The incidence in elderly patients with an ICD remains largely unknown. In younger patients, slow VT is generally asymptomatic or associated with limited clinical relevance. Read More

    Automated external defibrillator and operator performance in out-of-hospital cardiac arrest.
    Resuscitation 2017 May 16. Epub 2017 May 16.
    Department of Cardiology, Academic Medical Center, Amsterdam, The Netherlands.
    Aim: An increasing number of failing automated external defibrillators (AEDs) is reported: AEDs not giving a shock or other malfunction. We assessed to what extent AEDs are 'failing' and whether this had a device-related or operator-related cause.

    Methods: We studied analysis periods from AEDs used between January 2012 and December 2014. Read More

    Stretch-activated two-pore-domain (K2P) potassium channels in the heart: Focus on atrial fibrillation and heart failure.
    Prog Biophys Mol Biol 2017 May 16. Epub 2017 May 16.
    Department of Cardiology, University of Heidelberg, Heidelberg, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg / Mannheim, University of Heidelberg, Germany. Electronic address:
    Two-pore-domain potassium (K2P) channels modulate cellular excitability. The significance of stretch-activated cardiac K2P channels (K2P2.1, TREK-1, KCNK2; K2P4. Read More

    Left ventricular mural thrombus and dual coronary embolization associated with hyperthyroid cardiomyopathy and atrial fibrillation: a case report.
    BMC Cardiovasc Disord 2017 May 19;17(1):128. Epub 2017 May 19.
    Department of Cardiology, China-Japan Union Hospital, Jilin University, Changchun, Jilin Province, 130000, China.
    Background: The majority of acute myocardial infarction (AMI) events are caused by thrombotic occlusion of the coronary artery, secondary to atherosclerotic plaque erosion or rupture. However, coronary embolism (CE), while rare, is being increasingly recognized as an important cause of AMI. We present the case of a patient with multi-site coronary artery embolization associated with hyperthyroid-related cardiomyopathy and atrial fibrillation. Read More

    Nonpegylated liposomal doxorubicin combination regimen in patients with diffuse large B-cell lymphoma and cardiac comorbidity. Results of the HEART01 phase II trial conducted by the Fondazione Italiana Linfomi.
    Hematol Oncol 2017 May 19. Epub 2017 May 19.
    Division of Medical Oncology A, National Cancer Center, Istituto di Ricovero e Cura a Carattere Scientifico, Aviano, Pordenone, Italy.
    The purpose of this phase 2, multicenter study was to determine the activity and safety of nonpegylated liposomal doxorubicin as part of "R-COMP" combination in patients with diffuse large B-cell lymphoma and coexisting cardiac disorders. The study was conducted using a Bayesian continuing assessment method using complete remission rate and rate of cardiac events as study endpoints. Between November 2009 and October 2011, 50 evaluable patients were enrolled (median age, 76 years). Read More

    Arrhythmia burden and related outcomes in Eisenmenger syndrome.
    Congenit Heart Dis 2017 May 19. Epub 2017 May 19.
    Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
    Background: Patients with Eisenmenger syndrome have a shorter lifespan than the general population. A significant proportion develop arrhythmia and some, sudden death.

    Objective: The aims of this study were to characterize the frequency, type and effects of arrhythmias in adult patients with Eisenmenger's syndrome and to identify risk factors for arrhythmias. Read More

    Discovery of a new mutation in the desmin gene in a young patient with cardiomyopathy and muscular weakness.
    Rom J Morphol Embryol 2017 ;58(1):225-230
    Department of Cardiology, "Prof. Dr. C. C. Iliescu" Institute of Emergency for Cardiovascular Diseases, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania;
    A 25-year-old woman with a five years history of syncope, mild left ventricular hypertrophy and moderately enlarged atria, was diagnosed with third degree atrioventricular heart block alternating with atrioventricular heart block 2:1, and received a dual chamber pacemaker. After three years of evolution, she developed atrial fibrillation, marked biatrial enlargement, severely depressed longitudinal myocardial velocities, associated with mild girdle weakness and slight increase in creatine kinase level. The diagnosis of restrictive cardiomyopathy with mild skeletal myopathy imposed the screening for a common etiology. Read More

    Amyloidosis - a rare cause of refractory heart failure in a young female.
    Rom J Morphol Embryol 2017 ;58(1):201-206
    Department of Ophthalmology, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania;
    Cardiac amyloidosis may occur in any type of systemic amyloidosis. The clinical picture is often characterized by restrictive cardiomyopathy. We report the case of a 41-year-old female patient admitted to the Department of Cardiology with clinical signs of right heart failure: congested jugular veins, hepatomegaly, peripheral edema, ascites associated with atrial fibrillation, low values of arterial blood pressure and oliguria. Read More

    Synergistic Effect of Dofetilide and Mexiletine on Prevention of Atrial Fibrillation.
    J Am Heart Assoc 2017 May 18;6(5). Epub 2017 May 18.
    Department of Cardiology, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China
    Background: Although atrial fibrillation (AF) is the most common abnormal heart rhythm and its prevalence continues to rise, there is a marked paucity of effective and safe antiarrhythmic drugs for AF. This study was done to test whether combined use of dofetilide and mexiletine exhibits not only a synergistic effect on AF suppression but also a safer profile in drug-induced ventricular proarrhythmias.

    Methods And Results: The effects of dofetilide plus mexiletine on atrial effective refractory period (ERP), AF inducibility, QT, and QT-related ventricular arrhythmias were studied using the isolated arterially perfused rabbit atrial and ventricular wedge preparations. Read More

    The Girona Territori Cardioprotegit Project: Performance Evaluation of Public Defibrillators.
    Rev Esp Cardiol (Engl Ed) 2017 May 15. Epub 2017 May 15.
    Servicio de Cardiología, Hospital Universitari Dr. Josep Trueta, Girona, Spain; Departamento de Ciencias Médicas, Facultad de Medicina, Universidad de Girona, Girona, Spain; Centro de Genética Cardiovascular, Instituto de investigación biomédica de Girona (IDIBGI), Girona, Spain.
    Introduction And Objectives: In recent years, public access defibrillation programs have exponentially increased the availability of automatic external defibrillators (AED) in public spaces but there are no data on their performance in our setting. We conducted a descriptive analysis of the performance of AED since the launch of a public defibrillation program in our region.

    Methods: A retrospective analysis was conducted of electrocardiographic tracings and the performance of AED in a public defibrillation program from June 2011 to June 2015 in the province of Girona, Spain. Read More

    Dabigatran vs. warfarin in relation to the presence of left ventricular hypertrophy in patients with atrial fibrillation- the Randomized Evaluation of Long-term anticoagulation therapY (RE-LY) study.
    Europace 2017 May 17. Epub 2017 May 17.
    Department of Cardiology, Maggiore Hospital, Bologna, Italy.
    Aim: We tested the hypothesis that left ventricular hypertrophy (LVH) interferes with the antithrombotic effects of dabigatran and warfarin in patients with atrial fibrillation (AF).

    Methods And Results: This is a post-hoc analysis of the Randomized Evaluation of Long-term anticoagulation therapY (RE-LY) Study. We defined LVH by electrocardiography (ECG) and included patients with AF on the ECG tracing at entry. Read More

    Attitudes and preferences for the clinical management of hypertension and hypertension-related cerebrovascular disease in the general practice: results of the Italian hypertension and brain survey.
    Clin Hypertens 2017 15;23:10. Epub 2017 May 15.
    Hypertension Unit, Division of Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, University of Rome Sapienza, Sant'Andrea Hospital, Via di Grottarossa 1035, Rome, 00189 Italy.
    Background: The aim of this survey was to evaluate attitudes and preferences for the clinical management of hypertension and hypertension-related cerebrovascular diseases (CVD) in Italy.

    Methods: A predefined 16-item survey questionnaire was anonymously administered to a large community sample of general practitioners (GPs), trained by specialized physicians (SPs), who have been included in an educational program between January and November 2015.

    Results: A total of 591 physicians, among whom 48 (8%) training SPs and 543 (92%) trained GPs, provided 12,258 valid answers to the survey questionnaire. Read More

    Late Presentation of Aortic Aneurysm and Dissection Following Cardiac Catheterization.
    Cardiol Res 2017 Apr 3;8(2):68-72. Epub 2017 May 3.
    Division of Cardiology, University of South Alabama, Mobile, AL, USA.
    We report a 63-year-old female with hypertension, hyperlipidemia, and prior pacemaker insertion for atrial fibrillation with symptomatic bradycardia, who was admitted with substernal chest pressure and diaphoresis. Her electrocardiogram revealed atrial fibrillation with demand ventricular pacing and her cardiac biomarkers were negative for acute coronary syndrome. Echocardiogram revealed normal left ventricular systolic function and normal aortic root diameter. Read More

    Heart rate and outcome in heart failure with reduced ejection fraction: Differences between atrial fibrillation and sinus rhythm-A CIBIS II analysis.
    Clin Cardiol 2017 May 17. Epub 2017 May 17.
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
    Background: Heart rate has been associated with prognosis in patients with heart failure with reduced ejection fraction (HFREF) and sinus rhythm; whether this also holds true in patients with atrial fibrillation (AF) is unknown.

    Hypothesis: To evaluate cardiac rhythm and baseline heart rate and the influence of outcome in patients with HFREF enrolled in the Cardiac Insufficiency Bisoprolol Study II.

    Methods: In total, 2539 patients were stratified according to their baseline heart rhythm (AF or sinus rhythm) and into quartiles of heart rate (≤70 bpm, 71-78 bpm, 79-90 bpm, and >90 bpm). Read More

    When Cardioversion May Be Complicated.
    Isr Med Assoc J 2017 May;19(5):282-288
    Department of Cardiology, Assaf Harofeh Medical Center, Zerifin, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Background: In recent years cardioversion of atrial fibrillation has become a routine procedure, enabling symptomatic functional improvement in most cases. However, some patients develop complications after cardioversion. Identifying these individuals is an important step toward improving patient outcome. Read More

    Prevalence of early repolarization pattern in patients with lone atrial fibrillation.
    J Electrocardiol 2017 Apr 28. Epub 2017 Apr 28.
    Department of Medicine, Division of Cardiology, Weill Cornell Medical Center, New York, NY. Electronic address:
    Background: The objective of this study was to test the association of early repolarization pattern (ER) with lone atrial fibrillation (AF).

    Methods: Electrocardiograms (ECGs) were analyzed in blinded fashion in a case-control study of 182 patients with lone AF and 182 controls without AF.

    Results: Patients with lone AF and controls had similar frequencies of ER pattern (15% vs. Read More

    Impact of a Perioperative Prophylaxis Guideline on Post-Cardiothoracic Surgery Atrial Fibrillation.
    Ann Pharmacother 2017 May 1:1060028017709290. Epub 2017 May 1.
    5 Hartford Hospital Department of Pharmacy, Hartford, CT, USA.
    Background: National practice guidelines do not provide clear recommendations on combination pharmacological regimens to reduce cardiothoracic surgery (CTS) postoperative atrial fibrillation (POAF).

    Objective: This study examines if there is a reduction in POAF rates after implementing a perioperative prophylaxis guideline that includes amiodarone, β-blockers, and high-intensity statins.

    Methods: Data were retrospectively collected on 400 adults (200 patients pre-guideline implementation and 200 patients post-guideline implementation) with a CHA2DS2-VASc (Congestive Heart Failure, Hypertension, Age, Diabetes Mellitus, and Vascular Disease) score of at least 3 points after CTS. Read More

    Effectiveness of enzyme replacement therapy in Fabry disease: Long term experience in Argentina.
    Mol Genet Metab Rep 2017 Jun 4;11:65-68. Epub 2017 May 4.
    GADYTEF (Grupo Argentino de Diagnóstico y Tratamiento de la Enfermedad de Fabry), Argentina.
    Evidence regarding long term effectiveness of enzyme replacement therapy (ERT) in Fabry disease (FD) is needed. The aim of this study was to analyze in a cohort of FD patients in Argentina, the long term effectiveness of ERT on renal, cardiac and cerebrovascular parameters.

    Methods: Patients with genetically proven FD were included from GADYTEF (Argentinean group for the treatment of FD) between 2001 and 2014. Read More

    Non-Alcoholic Fatty Liver Disease Association with Cardiac Arrhythmias.
    Cureus 2017 Apr 13;9(4):e1165. Epub 2017 Apr 13.
    Cardiology, Orange Park Medical Center.
    Non-alcoholic fatty liver disease (NAFLD) has become a public health burden all over the world. A significant percentage of the patients with NAFLD have a co-existing metabolic syndrome that is a risk factor for cardiovascular disease. Clinical as well as epidemiological research shows that NAFLD is not simply related to liver-related morbidity and mortality but is also associated with an elevated risk of coronary heart disease (CHD), irregularities of cardiac function as well as cardiac structure, valvular heart disease, and arrhythmias. Read More

    Multiscale ordinal network analysis of human cardiac dynamics.
    Philos Trans A Math Phys Eng Sci 2017 Jun;375(2096)
    School of Mathematics and Statistics, The University of Western Australia, Crawley, Western Australia 6009, Australia.
    In this study, we propose a new information theoretic measure to quantify the complexity of biological systems based on time-series data. We demonstrate the potential of our method using two distinct applications to human cardiac dynamics. Firstly, we show that the method clearly discriminates between segments of electrocardiogram records characterized by normal sinus rhythm, ventricular tachycardia and ventricular fibrillation. Read More

    Alogliptin, a Dipeptidyl Peptidase-4 Inhibitor, Alleviates Atrial Remodeling and Improves Mitochondrial Function and Biogenesis in Diabetic Rabbits.
    J Am Heart Assoc 2017 May 15;6(5). Epub 2017 May 15.
    Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, China
    Background: There is increasing evidence implicating atrial mitochondrial dysfunction in the pathogenesis of atrial fibrillation. In this study, we explored whether alogliptin, a dipeptidyl peptidase-4 inhibitor, can prevent mitochondrial dysfunction and atrial remodeling in a diabetic rabbit model.

    Methods And Results: A total of 90 rabbits were randomized into 3 groups as follows: control group (n=30), alloxan-induced diabetes mellitus group (n=30), and alogliptin-treated (12. Read More

    COOL AMI EU pilot trial: a multicentre, prospective, randomised controlled trial to assess cooling as an adjunctive therapy to percutaneous intervention in patients with acute myocardial infarction.
    EuroIntervention 2017 May 17. Epub 2017 May 17.
    University Medical Center Ljubljana, Ljubljana, Slovenia.
    Aims: We aimed to investigate the rapid induction of therapeutic hypothermia using the ZOLL Proteus Intravascular Temperature Management System in patients with anterior ST-elevation myocardial infarction (STEMI) without cardiac arrest.

    Methods And Results: A total of 50 patients were randomised; 22 patients (88%; 95% confidence interval [CI]: 69-97%) in the hypothermia group and 23 patients (92%; 95% CI: 74-99) in the control group completed cardiac magnetic resonance imaging at four to six days and 30-day follow-up. Intravascular temperature at coronary guidewire crossing after 20. Read More

    Atrial antitachycardia pacing and atrial remodeling: a substudy of the international, randomized MINERVA trial.
    Heart Rhythm 2017 May 12. Epub 2017 May 12.
    Institute of Internal Medicine and Cardiology, University of Florence, Florence, Italy; IRCCS Multimedica, Sesto San Giovanni, Italy.
    Background: Atrial tachycardia (AT) and atrial fibrillation (AF) are common in pacemaker patients and are associated with bad prognosis.

    Objective: To evaluate atrial antitachycardia pacing impact on AT/AF induced atrial remodeling, measured by early recurrence of AT/AF (ERAF) and by change in left atrium diameter (LAD). To evaluate impact of AT/AF duration on ERAF incidence. Read More

    [Congenital heart disease in adolescents and adults: Management in a general cardiology department in Senegal].
    Ann Cardiol Angeiol (Paris) 2017 May 12. Epub 2017 May 12.
    Service de cardiologie, hôpital général de Grand-Yoff, BP 3270, Dakar, Sénégal.
    Background: Congenital heart diseases in adults include malformations treated in childhood that decompensate secondarily and those asymptomatic at birth, appear later. This study aims to identify congenital heart diseases in adults in general cardiology department of Senegal and to assess clinical presentations, treatment and outcomes.

    Methods: We conducted a cross-sectional and descriptive study based on the records of patients aged at least 16 years and followed for congenital heart disease in the cardiology department of the General Hospital of Grand-Yoff in Dakar between May 2003 and March 2015. Read More

    Impact of chronic obstructive pulmonary disease on in-hospital morbidity and mortality in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention.
    Int J Cardiol 2017 May 11. Epub 2017 May 11.
    University of Medicine and Pharmacy of Tîrgu Mureș, 540139 Tîrgu Mureș, Romania. Electronic address:
    Background: Patients with chronic obstructive pulmonary disease (COPD) presenting with ST-segment elevation myocardial infarction (STEMI) are less likely to beneficiate of primary percutaneous coronary intervention (pPCI), and have poorer prognosis. We aimed to evaluate the impact of COPD on the in-hospital outcomes of pPCI-treated STEMI patients.

    Methods: Data were collected from 418 STEMI patients treated by pPCI. Read More

    Synchronization as a Mechanism for Low-energy Anti-fibrillation Pacing (LEAP).
    Heart Rhythm 2017 May 11. Epub 2017 May 11.
    School of Physics, Georgia Institute of Technology, Atlanta GA.
    Background: Low-energy anti-fibrillation pacing (LEAP) has been suggested as an alternative treatment to symptomatic fibrillation patients. It significantly lowers the energy required compared with standard one-shock defibrillation.

    Objective: In this study, we investigated the mechanism of arrhythmia termination by LEAP and systematically analyzed the influence of shock period and timing on the success rate of LEAP. Read More

    Electrical Substrate Elimination in 135 Consecutive Patients With Brugada Syndrome.
    Circ Arrhythm Electrophysiol 2017 May;10(5):e005053
    From the Arrhythmology Department (C.P., G.V., G.C., F.M., M.S., R.V., A.C., L.G., Z.C., M.C., A.N., S.C., V.B., V.S.) and Cardiac Surgery Department (A.F., L.M.), IRCCS Policlinico San Donato, San Donato Milanese, Italy; Cardiology Department, Cardiovascular Institute, Hospital Clinic and IDIBAPS, Barcelona, Catalonia (J.B.); Cardiology Department, Hospital Trueta, Girona, Spain (R.B.); Department of Medical Sciences, University of Girona & IDIBGI, Spain (); Pediatric Arrhythmias, Electrophysiology and Sudden Death Unit, Cardiology Department, Hospital Sant Joan de Deu, Barcelona, Spain (G.S.-B.); and Cardiology Department, IRCCS Policlinico San Donato, University of Milan, Italy (M.G.).
    Background: There is emerging evidence that localization and elimination of abnormal electric activity in the epicardial right ventricular outflow tract may be beneficial in patients with Brugada syndrome.

    Methods And Results: A total of 135 symptomatic Brugada syndrome patients having implantable cardiac defibrillator were enrolled: 63 (group 1) having documented ventricular tachycardia (VT)/ventricular fibrillation (VF) and Brugada syndrome-related symptoms, and 72 (group 2) having inducible VT/VF without ECG documentation at the time of symptoms. About 27 patients of group 1 experienced multiple implantable cardiac defibrillator shocks for recurrent VT/VF episodes. Read More

    Determinants of decline of renal function in treated hypertensive patients: the Campania Salute Network.
    Nephrol Dial Transplant 2017 May 12. Epub 2017 May 12.
    Hypertension Research Center, University of Naples, Federico II, Naples, Italy.
    Background.: Hypertension is a leading cause of chronic kidney disease (CKD) and a decrease in glomerular filtration rate (GFR) is associated with a higher prevalence of hypertension and an increased proportion of suboptimal blood pressure (BP) control.

    Methods. Read More

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