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    Efficiency of ranolazine in the patient with microvascular angina, atrial fibrillation and migraine.
    Wiad Lek 2016 ;69(6):832-837
    Department of Internal Therapy №1 of Vinnitsa National Pirogov Memorial Medical University, Vinnitsa, Ukraine.
    Microvascular angina (MVA) is rather a common form of stable ischemic coronary disease (CAD) as that such diagnosis is made in 20-30% of patients who previously underwent coronary angiography. The disease occurs three times more frequently in women than in men irrespective of age. Most of these patients are 45-60 years old. Read More

    Suppression of Tumorigenicity 2 in Heart Failure With Preserved Ejection Fraction.
    J Am Heart Assoc 2017 Feb 18;6(2). Epub 2017 Feb 18.
    Mayo Clinic, Rochester, MN
    Background: Soluble suppression of tumorigenicity 2 (sST2) receptor is a biomarker that is elevated in certain systemic inflammatory diseases. Comorbidity-driven microvascular inflammation is postulated to play a key role in heart failure with preserved ejection fraction (HFpEF) pathophysiology, but data on how sST2 relates to clinical characteristics or inflammatory conditions or biomarkers in HFpEF are limited. We sought to determine circulating levels and clinical correlates of sST2 in HFpEF. Read More

    Contemporary animal models of cardiac arrest: A systematic review.
    Resuscitation 2017 Feb 15. Epub 2017 Feb 15.
    Department of Anaesthesiology and Intensive Care Medicine, Aarhus University Hospital, Aarhus, Denmark; Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark. Electronic address:
    Aim Of The Study: Animal models are widely used in cardiac arrest research. This systematic review aimed to provide an overview of contemporary animal models of cardiac arrest.

    Methods: Using a comprehensive research strategy, we searched PubMed and EMBASE from March 8, 2011 to March 8, 2016 for cardiac arrest animal models. Read More

    Relation Between Ventricular Premature Complexes and Incident Heart Failure.
    Am J Cardiol 2017 Jan 25. Epub 2017 Jan 25.
    Division of Cardiology, Electrophysiology Section, University of California, San Francisco, California. Electronic address:
    Ventricular premature complexes (VPCs) may represent a reversible cause of heart failure (HF); however, the type of patients most prone remains unknown. This study leverages a large population-based database to examine interactions that might prove clinically useful in risk-stratifying patients with VPCs. We used the California Healthcare Cost and Utilization Project to identify patients with VPCs and incident systolic HF from January 1, 2005, to December 31, 2009. Read More

    Comparison of Pulmonary Venous and Left Atrial Remodeling in Patients With Atrial Fibrillation With Hypertrophic Cardiomyopathy Versus With Hypertensive Heart Disease.
    Am J Cardiol 2017 Jan 25. Epub 2017 Jan 25.
    Division of Cardiovascular Medicine, Ibaraki Prefectural Central Hospital, Kasama, Japan.
    Left ventricular diastolic dysfunction in hypertrophic cardiomyopathy (HC) increases susceptibility to atrial fibrillation. Although phenotypical characteristics of the hypertrophied left ventricle are clear, left atrial (LA) and pulmonary venous (PV) remodeling has rarely been investigated. This study aimed to identify differences in LA and PV remodeling between HC and hypertensive heart disease (HHD) using 3-dimensional computed tomography. Read More

    Correlations between electrocardiogram and biomarkers in acute pulmonary embolism: Analysis of ZATPOL-2 Registry.
    Ann Noninvasive Electrocardiol 2017 Feb 18. Epub 2017 Feb 18.
    Department of Pulmonary Circulation and Thromboembolic Diseases, The Medical Centre of Postgraduate Medication, European Health Centre Otwock, Otwock, Poland.
    Background: Electrocardiography (ECG) is still one of the first tests performed at admission, mostly in patients (pts) with chest pain or dyspnea. The aim of this study was to assess the correlation between electrocardiographic abnormalities and cardiac biomarkers as well as echocardiographic parameter in patients with acute pulmonary embolism.

    Methods: We performed a retrospective analysis of 614 pts. Read More

    Emergency extracorporeal life support and ongoing resuscitation: a retrospective comparison for refractory out-of-hospital cardiac arrest.
    Emerg Med J 2017 Feb 17. Epub 2017 Feb 17.
    Department of Emergency Medicine, Medical University of Vienna, Waehringer Guertel, Vienna, Austria.
    Background: In refractory cardiac arrest, with cardiopulmonary resuscitation (CPR) for more than 30 min, chances of survival are small. Extracorporeal cardiopulmonary resuscitation (ECPR) is an option for certain patients with cardiac arrest. The aim of this study was to evaluate characteristics of patients selected for ECPR. Read More

    Role of Apamin-Sensitive Calcium-Activated Small-Conductance Potassium Currents on the Mechanisms of Ventricular Fibrillation in Pacing-Induced Failing Rabbit Hearts.
    Circ Arrhythm Electrophysiol 2017 Feb;10(2):e004434
    From the Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis (D.Y., Y.-C.H., W.-C.T., A.Z.-Y.W., Z.J., Y.-H.C., D.X., N.Y., Z.C., S.-F.L., P.-S.C., T.H.E.); Department of Cardiology (D.Y.) and Department of Gynecological and Obstetric Ultrasound (N.Y.), First Affiliated Hospital of Harbin Medical University, China; Cardiovascular Center, Taichung Veterans General Hospital and Department of Internal Medicine, Faculty of Medicine, Institute of Clinical Medicine, Cardiovascular Research Center, National Yang-Ming University School of Medicine, Taipei (Y.-C.H.); Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Taiwan (W.-C.T.); Institute of Biomedical Engineering, National Chiao-Tung University, Hsin-Chu, Taiwan (A.Z.-Y.W., S.-F.L.); Department of Cardiothoracic Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, China (Z.J.); Division of Cardiology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Linkou, Taoyuan, Taiwan (Y.-H.C.); Department of Cardiology, Faculty of Medicine, University of Tsukuba, Japan (D.X.); and Richard and Susan Smith Center for Outcomes Research in Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA (C.S.).
    Background: Ventricular fibrillation (VF) during heart failure is characterized by stable reentrant spiral waves (rotors). Apamin-sensitive small-conductance calcium-activated potassium currents (IKAS) are heterogeneously upregulated in failing hearts. We hypothesized that IKAS influences the location and stability of rotors during VF. Read More

    Interleukin-1β levels predict long-term mortality and need for heart transplantation in ambulatory patients affected by idiopathic dilated cardiomyopathy.
    Oncotarget 2017 Feb 15. Epub 2017 Feb 15.
    Cardiovascular Department, Azienda Sanitaria Universitaria Integrata di Trieste and University of Trieste, Trieste, Italy.
    Aims: The prognostic stratification of patients with Idiopathic Dilated Cardiomyopathy (iDCM) is a difficult task. Here, we assessed the additive value of the evaluation of biomarkers of inflammasome activation and systemic inflammation for the long-term risk stratification of iDCM patients.

    Methods And Results: We studied 156 ambulatory iDCM patients (mean age 58 years, 77% men, 79% in NYHA class 1-2, median Left Ventricular Ejection Fraction (LVEF) 35%, mean sodium 139 mEq/L, median BNP 189 pg/mL, median IL-1 beta (IL-1β) 1. Read More

    Pharmacologic cardioversion with intravenous amiodarone is likely safe in neurocritically Ill patients.
    J Clin Neurosci 2017 Feb 13. Epub 2017 Feb 13.
    Departments of Neurology and Neurocritical Care, Cedars-Sinai Medical Center, 127 S. San Vicente Blvd, Suite A6600, Los Angeles, CA 90048, United States. Electronic address:
    Neurological injury is often associated with cardiac abnormalities, including electrophysiological issues. Cardioversion of acute atrial fibrillation (<48h' duration) without anticoagulation carries about a 0.7% risk of thromboembolism. Read More

    [Acute chest pain and new ECG changes in pacemaker patients : A clinical challenge].
    Herzschrittmacherther Elektrophysiol 2017 Feb 15. Epub 2017 Feb 15.
    Klinik für Innere Medizin I, Universitätsklinikum Jena, Erlanger Allee 101, 07740, Jena, Deutschland.
    We report the case of a 82-year-old woman who was admitted to our institution with acute chest pain, nausea, and vomiting. Because of atrial fibrillation with intermittent bradycardia, a single-chamber pacemaker was implanted 4 years ago. The initial 12-lead ECG showed atrial fibrillation with a heart rate of 70 bpm, narrow QRS, and T‑wave inversions in the inferolateral leads. Read More

    Effects of Upgrade Versus De Novo Cardiac Resynchronization Therapy on Clinical Response and Long-Term Survival: Results from a Multicenter Study.
    Circ Arrhythm Electrophysiol 2017 Feb;10(2):e004471
    From the Department of Cardiology, J.W. Goethe University, Frankfurt, Germany (M.V., J.W.E., S.P.L., S.H.H.); Department of Cardiology, Medical Centre, Hungarian Defence Forces, Budapest, Hungary (Z.B., D.V., G.Z.D.); and Department of Cardiology, Evangelical Hospital Bielefeld, Germany (T.B., C.W.I.).
    Background: Benefits of cardiac resynchronization therapy (CRT) on morbidity and mortality in selected patients are well known. Although the number of upgrade procedures from single- or dual-chamber devices to CRT is increasing, there are only sparse data on the outcomes of upgrade procedures compared with de novo CRT. This study aimed to evaluate clinical response and survival in patients receiving de novo versus upgrade CRT defibrillator therapy. Read More

    Therapeutic hypothermia attenuates brain edema in a pig model of cardiac arrest: Possible role of the angiopoietin-Tie-2 system.
    Am J Emerg Med 2017 Feb 6. Epub 2017 Feb 6.
    Beijing Key Laboratory of Cardiopulmonary-Cerebral Resuscitation, Department of Emergency Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
    Objective: This study aimed to clarify whether therapeutic hypothermia protects against cerebral edema following cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) in a porcine model via regulating the angiopoietin-Tie-2 ligand-receptor system.

    Methods: Male pigs were randomized into the therapeutic hypothermia group, the normothermia group or the sham control group. CA was induced in pigs by untreated ventricular fibrillation for 8min. Read More

    Predictors of Permanent Pacemaker Implantation After Coronary Artery Bypass Grafting and Valve Surgery in Adult Patients in Current Surgical Era.
    Cardiol Res 2016 Aug 5;7(4):123-129. Epub 2016 Sep 5.
    Heart Centre, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
    Background: Permanent pacemaker (PPM) implantation after cardiac surgery is required in 0.4-6% of patients depending on cardiac surgery type. PPM implantation in the early postoperative period may reduce morbidity and postoperative hospital stay. Read More

    Left Atrial Structure in Relationship to Age, Sex, Ethnicity, and Cardiovascular Risk Factors: MESA (Multi-Ethnic Study of Atherosclerosis).
    Circ Cardiovasc Imaging 2017 Feb;10(2)
    From the Centre for Advanced Cardiovascular Imaging, Queen Mary University of London, Barts Heart Centre, United Kingdom (F.Z., S.A.M., S.E.P.); Cardiology Division, Department of Medicine, Johns Hopkins Hospital, Baltimore, MD (B.A.-V., J.C., E.C., M.H., S.N., J.A.C.L.); Institute of Cardiovascular Science, University College London, United Kingdom (G.C., J.C.M.); and Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD (D.A.B.).
    Background: Left atrial (LA) size is a marker of diastolic function and is associated with atrial fibrillation and cardiovascular outcomes. However, there are no large population studies measuring LA structure. The relationship of demographics and cardiovascular risk factors to LA size is largely unknown. Read More

    Renal sympathetic stimulation and ablation affect ventricular arrhythmia by modulating autonomic activity in a cesium-induced long QT canine model.
    Heart Rhythm 2017 Feb 10. Epub 2017 Feb 10.
    Department of Cardiology, Renmin Hospital of Wuhan University; Cardiovascular Research Institute, Wuhan University; Hubei Key Laboratory of Cardiology, Wuhan, Hubei, China. Electronic address:
    Background: Our previous studies have shown that renal sympathetic stimulation (RS) may facilitate ischemic ventricular arrhythmia (VA) by increasing left stellate ganglion (LSG) nerve activity, while renal sympathetic ablation (RA) may suppress VA.

    Objective: This study aimed to investigate whether renal sympathetic interventions could also affect VA by modulating LSG activity in a cesium-induced long QT canine model.

    Methods: Twenty-four dogs were randomly divided into RS group (n=8), RA group (n=8), and control group (n=8). Read More

    The clinical utility of normal findings on noninvasive cardiac assessment in the prediction of atrial fibrillation.
    Clin Cardiol 2017 Feb 13. Epub 2017 Feb 13.
    Department of Internal Medicine, Section on Cardiology, Wake Forest School of Medicine, Winston-Salem, North Carolina.
    Background: The absence of abnormalities on noninvasive cardiac assessment possibly confers a reduced risk of atrial fibrillation (AF) despite the presence of traditional risk factors.

    Hypothesis: Normal findings on noninvasive cardiac assessment are associated with a lower risk of AF development.

    Methods: We examined the clinical utility of normal findings on routine noninvasive cardiac assessment in 5331 participants (85% white; 57% women) from the Cardiovascular Health Study who were free of baseline AF. Read More

    Apical left ventricular myocardial dysfunction is an early feature of cardiac involvement in myotonic dystrophy type 1.
    Echocardiography 2017 Feb 13. Epub 2017 Feb 13.
    Cardiology Service, CHU Poitiers, Poitiers, France.
    Introduction: Left ventricular (LV) dysfunction is a major prognostic determinant in myotonic dystrophy type 1 (DM1). Therefore, markers of early-stage LV impairment may be useful. The aim of this study was to evaluate 2D echocardiographic LV strain in a cohort of DM1 patients with preserved left ventricular ejection fraction (LVEF) and to compare the results with matched controls. Read More

    MEMS-Based Flexible Force Sensor for Tri-Axial Catheter Contact Force Measurement.
    J Microelectromech Syst 2017 Feb 22;26(1):264-272. Epub 2016 Dec 22.
    Medical Robotics and Automation Laboratory (RoboMed) in the Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
    Atrial fibrillation (AFib) is a significant healthcare problem caused by the uneven and rapid discharge of electrical signals from pulmonary veins (PVs). The technique of radiofrequency (RF) ablation can block these abnormal electrical signals by ablating myocardial sleeves inside PVs. Catheter contact force measurement during RF ablation can reduce the rate of AFib recurrence, since it helps to determine effective contact of the catheter with the tissue, thereby resulting in effective power delivery for ablation. Read More

    Electrocardiographic Intervals Associated with Incident Atrial Fibrillation: Dissecting the QT-interval.
    Heart Rhythm 2017 Feb 8. Epub 2017 Feb 8.
    Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of California San Francisco, San Francisco, California, USA. Electronic address:
    Background: Prolongation of the QT-interval has been associated with an increased risk for developing atrial fibrillation (AF), but the responsible mechanism remains unknown.

    Objective: To sub-divide the QT-interval into its components and identify the resultant electrocardiographic interval(s) responsible for the association with AF.

    Methods: Pre-defined QT-interval components were assessed for association with incident AF in the Atherosclerosis Risk in Communities (ARIC) Study using Cox proportional hazards models. Read More

    Comparison of different inspiratory triggering settings in automated ventilators during cardiopulmonary resuscitation in a porcine model.
    PLoS One 2017 10;12(2):e0171869. Epub 2017 Feb 10.
    Department of Emergency, Peking Union Medical College Hospital, Chinese Academy of Medical sciences, Beijing, China.
    Background: Mechanical ventilation via automated in-hospital ventilators is quite common during cardiopulmonary resuscitation. It is not known whether different inspiratory triggering sensitivity settings of ordinary ventilators have different effects on actual ventilation, gas exchange and hemodynamics during resuscitation.

    Methods: 18 pigs enrolled in this study were anaesthetized and intubated. Read More

    Utility of CHA2DS2-VASc and HAS-BLED Scores as Predictor of Thromboembolism and Bleeding After Left Ventricular Assist Device Implantation.
    ASAIO J 2017 Feb 7. Epub 2017 Feb 7.
    * Near East University Faculty of Medicine, Department of Cardiology, Nicosia, Cyprus ¶ Ege University Faculty of Medicine, Department of Cardiovascular Surgery, Izmir, Turkey * Ege University Faculty of Medicine, Department of Cardiology, Izmir, Turkey.
    Ischemic and hemorrhagic events are the common causes of morbidity and mortality after continuous-flow left ventricular assist device implantation (CF-LVAD). CHA2DS2-VASc score predicts thromboembolic (TE) event risk and HAS-BLED score predicts bleeding risk in patients on anti-coagulant with atrial fibrillation. We aimed to evaluate if these scoring systems would be predictive of TE and bleeding complications following CF-LVAD implantation. Read More

    Discrimination Between QRS and T Waves Using a Right Parasternal Lead for S-ICD in a Patient with a Single Ventricle.
    Pacing Clin Electrophysiol 2017 Feb 9. Epub 2017 Feb 9.
    Department of Cardiology, Keio University School of Medicine, Tokyo, 160-8582, Japan.
    The subcutaneous implantable cardioverter-defibrillator (S-ICD) is a useful option for patients with a single ventricle (SV) in which transvenous leads are contraindicated because of intracardiac shunts. We report a case in which a right parasternal lead placement was indicated for an S-ICD in a resuscitated patient with an SV. There were significant changes in the magnitude of R to T waves ratio in the right compared to left parasternal lead position. Read More

    [A life-saving shock from a subcutaneous ICD during skydiving].
    Herzschrittmacherther Elektrophysiol 2017 Feb 9. Epub 2017 Feb 9.
    I. Medizinische Klinik, Abteilung für Kardiologie, Pneumologie, Angiologie und internistische Intensivmedizin, Universitätsklinikum Mannheim, Universität Heidelberg und Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), Standort Mannheim/Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Deutschland.
    We report the case of a 38-year-old man who was implanted a subcutaneous implantable cardioverter-defibrillator (S-ICD) and then performed a skydive from a height of 3000 m. During the jump, he lost consciousness due to ventricular fibrillation (VF). The S‑ICD detected the VF properly and successfully shocked the arrhythmia. Read More

    Local Left Ventricular Epicardial J Waves and Late Potentials in Brugada Syndrome Patients with Inferolateral Early Repolarization Pattern.
    Front Physiol 2017 26;8:14. Epub 2017 Jan 26.
    Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center Osaka, Japan.
    Background: Brugada syndrome (BrS) is characterized by J-point or ST-segment elevation on electrocardiograms (ECGs) and increased risk of ventricular fibrillation (VF). In BrS, epicardial depolarization abnormality with delayed potential on the right ventricular outflow tract is reportedly the predominant mechanism underlying VF. Yet VF occurrence is also associated with early repolarization (ER) pattern in the inferolateral ECG leads, which may represent the inferior and/or left lateral ventricular myocardium. Read More

    Cervical sympathetic blockade for the management of electrical storm.
    J Clin Anesth 2017 Feb 18;36:47-50. Epub 2016 Nov 18.
    Icahn School of Medicine at Mount Sinai Department of Anesthesiology/Division of Pain Medicine, New York, NY.
    A 75-year-old man presented with dizziness and fatigue secondary to ventricular and supraventricular arrhythmias. He underwent an elective ablation but continued to suffer from ventricular tachycardia with cardiovascular instability despite antiarrhythmic therapy with multiple agents. The patient continued to develop episodes of ventricular tachycardia and an episode of ventricular fibrillation. Read More

    Ranolazine Added to Amiodarone Facilitates Earlier Conversion of Atrial Fibrillation Compared to Amiodarone-Only Therapy.
    Pacing Clin Electrophysiol 2017 Feb 9. Epub 2017 Feb 9.
    Department of Cardiology at University Hospital of Larissa.
    Amiodarone (AMIO) is for many years effectively used to control ventricular rate during atrial fibrillation (AF) and to convert it into sinus rhythm. However, due to its delayed onset of action, ranolazine (RAN), a new antianginal agent with atrial-selective electrophysiologic properties, has recently been attempted as add-on therapy with AMIO to facilitate AF conversion. To establish the role of this combination therapy, we enrolled 173 consecutive patients (68±10 years, 54% male) with recent-onset (< 48 h duration) AF who were eligible for pharmacologic cardioversion. Read More

    Modulation of Autonomic Nervous Activity in the Termination of Paroxysmal Atrial Fibrillation.
    Pacing Clin Electrophysiol 2017 Feb 9. Epub 2017 Feb 9.
    Division of Cardiovascular Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
    Background: Autonomic nervous activity plays a critical role in the genesis of paroxysmal atrial fibrillation (AF, PAF). However, the role of autonomic nervous activity on AF termination has not been elucidated. Heart rate variability (HRV) is widely used to evaluate autonomic nervous activity in humans. Read More

    Is there a role of iNOS activation in the delayed antiarrhythmic effect of sodium nitrite?
    Can J Physiol Pharmacol 2016 Nov 24. Epub 2016 Nov 24.
    University of Szeged, Albert Szent-Györgyi Medical Center, Szeged, Hungary, Department of Pharmacology, Pharmacotherapy , Dóm tér 12 , Szeged, Hungary , 6720 ;
    This study aimed to examine whether inducible nitric oxide synthase (iNOS) plays a role in the delayed antiarrhythmic effect of sodium nitrite. Twenty-one dogs were infused intravenously with sodium nitrite (0.2 µmol/kg/min) for 20 min, either in the absence (n=12) or in the presence of the iNOS inhibitor S-(2-aminoethyl)-isothiourea (AEST; total dose: 2. Read More

    A Randomised tRial of Expedited transfer to a cardiac arrest centre for non-ST elevation ventricular fibrillation out-of-hospital cardiac arrest: The ARREST pilot randomised trial.
    Resuscitation 2017 Feb 4. Epub 2017 Feb 4.
    Cardiovascular Division, The Rayne Institute BHF Centre of Research Excellence, King's College London, St. Thomas' Hospital, London, UK. Electronic address:
    Background: Wide variation exists in inter-hospital survival from out-of-hospital cardiac arrest (OHCA). Regionalisation of care into cardiac arrest centres (CAC) may improve this. We report a pilot randomised trial of expedited transfer to a CAC following OHCA without ST-elevation. Read More

    Emergency Medicine Myths: Epinephrine in Cardiac Arrest.
    J Emerg Med 2017 Feb 4. Epub 2017 Feb 4.
    Department of Emergency Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas.
    Background: Sudden cardiac arrest accounts for approximately 15% of deaths in developed nations, with poor survival rate. The American Heart Association states that epinephrine is reasonable for patients with cardiac arrest, though the literature behind its use is not strong.

    Objective: To review the evidence behind epinephrine for cardiac arrest. Read More

    Alternative Approaches for Ablation of Resistant Ventricular Tachycardia.
    Card Electrophysiol Clin 2017 Mar 24;9(1):93-98. Epub 2016 Dec 24.
    Texas Cardiac Arrhythmia Institute, St. David's Medical Center, 3000 N. IH-35, Suite 720, Austin, TX 78705, USA. Electronic address:
    Ventricular tachycardia (VT) ablation is usually performed with an ablation catheter that delivers unipolar radiofrequency (RF) energy to eliminate the re-entry circuit responsible for VT. However, there are some instances when unipolar RF ablation fails, notably in VTs with a deep intramural origin, or cases in which epicardial access is not attainable due to prior cardiac surgery. To overcome these limitations, several alternative approaches have been used in clinical practice, including alcohol ablation or coil embolization, simultaneous unipolar or bipolar RF ablation, surgical ablation, or noninvasive ablation with stereotactic radiosurgery. Read More

    Fluoroless Catheter Ablation of Cardiac Arrhythmias: A 5-Year Experience.
    Pacing Clin Electrophysiol 2017 Feb 3. Epub 2017 Feb 3.
    Section of Cardiology and Clinical Cardiac Electrophysiology, Advocate Illinois Masonic Medical Center, Chicago, IL.
    Background: Catheter ablations have been traditionally performed with the use of fluoroscopic guidance, which exposes the patient and staff to the inherent risks of radiation. We have developed techniques to eliminate the use of fluoroscopy during cardiac ablations and have been performing completely fluoroless catheter ablations on our patients for over 5 years.

    Methods: We present a retrospective analysis of the safety, efficacy, and feasibility data from 500 consecutive patients who underwent nonfluoroscopic catheter ablation, targeting a total of 639 arrhythmias, including atrioventricular reciprocating tachycardia (AVRT), atrioventricular nodal reentrant tachycardia (AVNRT), atrial tachycardia (AT), atrial fibrillation (AF), premature ventricular contractions (PVC), and ventricular tachycardia (VT). Read More

    Beta-Blocker Use Is Associated With Impaired Left Atrial Function in Hypertension.
    J Am Heart Assoc 2017 Feb 3;6(2). Epub 2017 Feb 3.
    Hospital of the University of Pennsylvania, Philadelphia, PA
    Background: Impaired left atrial (LA) mechanical function is present in hypertension and likely contributes to various complications, including atrial arrhythmias, stroke, and heart failure. Various antihypertensive drug classes exert differential effects on central hemodynamics and left ventricular function. However, little is known about their effects on LA function. Read More

    Changing target temperature from 33°C to 36°C in the ICU management of out-of-hospital cardiac arrest: A before and after study.
    Resuscitation 2017 Jan 31;113:39-43. Epub 2017 Jan 31.
    Department of Epidemiology and Preventive Medicine, Monash University, Australia; The Alfred Hospital, Australia; Ambulance Victoria, Australia.
    Introduction: In December 2013, our institution changed the target temperature management (TTM) for the first 24h in ventricular fibrillation out-of-hospital cardiac arrest (VF-OHCA) patients from 33°C to 36°C. This study aimed to examine the impact this change had on measured temperatures and patient outcomes.

    Methods: We conducted a retrospective cohort study of consecutive VF-OHCA patients admitted to a tertiary referral hospital in Melbourne (Australia) between January 2013 and August 2015. Read More

    Impaired Mental Health-related Quality of Life in Patients with Idiopathic Ventricular Fibrillation.
    Pacing Clin Electrophysiol 2017 Feb 3. Epub 2017 Feb 3.
    Department of Cardiology, University Medical Centre, Utrecht, The Netherlands.
    Background: Idiopathic ventricular fibrillation (iVF) is diagnosed in cardiac arrest survivors without an identifiable cause. Data regarding the health-related quality of life (HRQoL) in iVF patients are lacking. The purpose of this study was to investigate the HRQoL of iVF patients and to compare it to patients with an implantable cardioverter defibrillator (ICD) diagnosed with an underlying disease and healthy subjects. Read More

    QT Prolongation due to Graves' Disease.
    Case Rep Cardiol 2017 5;2017:7612748. Epub 2017 Jan 5.
    Department of Internal Medicine, Crittenton Hospital Medical Center, Wayne State University, Rochester, MI 48307, USA.
    Hyperthyroidism is a highly prevalent disease affecting over 4 million people in the US. The disease is associated with many cardiac complications including atrial fibrillation and also less commonly with ventricular tachycardia and fibrillation. Many cardiac pathologies have been extensively studied; however, the relationship between hyperthyroidism and rate of ventricular repolarization manifesting as a prolonged QTc interval is not well known. Read More

    Cardiac Resynchronization Therapy Device Implantation in a Patient with Cardiogenic Shock under Percutaneous Mechanical Circulatory Support.
    Korean Circ J 2017 Jan 23;47(1):132-135. Epub 2016 Dec 23.
    Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
    65-year-old woman was admitted to our hospital with acute decompensated heart failure with reduced left ventricular ejection fraction and severe mitral regurgitation. Electrocardiography revealed a typical left bundle branch block and atrial fibrillation. Her condition deteriorated despite administering high-doses of inotropes and vasopressors. Read More

    Cardioembolic Stroke.
    Circ Res 2017 Feb;120(3):514-526
    From the Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute (H.K.) and Department of Neurology, Weill Cornell Medicine, New York, NY (H.K.); and Department of Medicine and Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada (J.S.H.).
    Cardiac embolism accounts for an increasing proportion of ischemic strokes and might multiply several-fold during the next decades. However, research points to several potential strategies to stem this expected rise in cardioembolic stroke. First, although one-third of strokes are of unclear cause, it is increasingly accepted that many of these cryptogenic strokes arise from a distant embolism rather than in situ cerebrovascular disease, leading to the recent formulation of embolic stroke of undetermined source as a distinct target for investigation. Read More

    Atrial Fibrillation and Ventricular Arrhythmias: Sex Differences in Electrophysiology, Epidemiology, Clinical Presentation, and Clinical Outcomes.
    Circulation 2017 Feb;135(6):593-608
    From Department of Cardiac Sciences, University of Calgary and Libin Cardiovascular Institute of Alberta, Calgary, Canada.
    Sex-specific differences in the epidemiology, pathophysiology, clinical presentation, clinical treatment, and clinical outcomes of atrial fibrillation (AF), sustained ventricular arrhythmias, and sudden cardiac death are recognized. Sex hormones cause differences in cardiac electrophysiological parameters between men and women that may affect the risk for arrhythmias. The incidence and prevalence of AF is lower in women than in men. Read More

    Usefulness of the MrWALLETS Scoring System to Predict First Diagnosed Atrial Fibrillation in Patients With Ischemic Stroke.
    Am J Cardiol 2017 Jan 5. Epub 2017 Jan 5.
    Stroke Unit, Medical Department of Continuity of Care and Disability, S.Orsola-Malpighi Hospital, Bologna, Italy; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
    Some cryptogenic strokes are caused by undetected paroxysmal atrial fibrillation (AF) and could benefit from oral anticoagulation. In this study, we searched for echocardiographic parameters associated with first diagnosed AF, to form a scoring system for the identification of patients with AF. We examined 571 patients with ischemic stroke (72. Read More

    Supplement of levosimendan to epinephrine improves initial resuscitation outcomes from asphyxial cardiac arrest.
    BMC Anesthesiol 2017 Feb 2;17(1):18. Epub 2017 Feb 2.
    Department of Anesthesiology, The First Affiliated Hospital, Wenzhou Medical University, Wenzhou City, Zhejiang Province, China.
    Background: Levosimendan exerted favorable effects on the initial outcome in the treatment of ventricular fibrillation cardiac arrest. This study investigated the efficacy of levosimendan in the treatment of asphyxia-induced cardiac arrest in rats.

    Methods: Animals underwent asphyxial cardiac arrest/cardiopulmonary resuscitation, randomized to three treatment groups: epinephrine (10 μg/kg) supplemented with levosimendan (bolus 12 μg/kg and infusion for 1 h, EL group); epinephrine only (10 μg/kg, E group), or levosimendan only (bolus 12 μg/kg and infusion for 1 h, L group). Read More

    Syncope: Outcomes and Conditions Associated with Hospitalization.
    Am J Med 2017 Jan 29. Epub 2017 Jan 29.
    University of Iowa Hospitals and Clinics. Iowa City, IA.
    Purpose: Syncope is a perplexing problem for which hospital admission and readmission are contemplated but outcomes remain uncertain. Our purpose was to determine the incidence of admissions and readmissions for syncope and compare associated conditions, in-hospital outcomes and resource utilization.

    Methods: The 2005-2011 California Statewide Inpatient Database was utilized. Read More

    A multicenter prospective randomized study comparing the efficacy of escalating higher biphasic versus low biphasic energy defibrillations in patients presenting with cardiac arrest in the in-hospital environment.
    Open Access Emerg Med 2017 13;9:9-17. Epub 2017 Jan 13.
    Department of Emergency Medicine, Singapore General Hospital.
    Background: Biphasic defibrillation has been practiced worldwide for >15 years. Yet, consensus does not exist on the best energy levels for optimal outcomes when used in patients with ventricular fibrillation (VF)/pulseless ventricular tachycardia (VT).

    Methods: This prospective, randomized, controlled trial of 235 adult cardiac arrest patients with VF/VT was conducted in the emergency and cardiology departments. Read More

    Long-term follow-up of arrhythmogenic right ventricular cardiomyopathy patients with an implantable cardioverter-defibrillator for prevention of sudden cardiac death.
    Clin Cardiol 2017 Jan 31. Epub 2017 Jan 31.
    State Key Laboratory of Cardiovascular Disease, Cardiac Arrhythmia Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
    Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare inherited cardiomyopathy with a high burden of ventricular arrhythmia, which is an important cause of sudden cardiac death (SCD). Implantable cardioverter-defibrillator (ICD) is believed to be the most reliable management against SCD.

    Hypothesis: Ventricular arrhythmia does not necessarily confer a poor prognosis in ARVC patients with an ICD. Read More

    Development and Implementation of a Comprehensive, Multidisciplinary Emergency Department Extracorporeal Membrane Oxygenation Program.
    Ann Emerg Med 2017 Jan 27. Epub 2017 Jan 27.
    Division of Cardiothoracic Surgery, Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT.
    Despite advances in the medical and surgical management of cardiovascular disease, greater than 350,000 patients experience out-of-hospital cardiac arrest in the United States annually, with only a 12% neurologically favorable survival rate. Of these patients, 23% have an initial shockable rhythm of ventricular fibrillation/pulseless ventricular tachycardia (VF/VT), a marker of high probability of acute coronary ischemia (80%) as the precipitating factor. However, few patients (22%) will experience return of spontaneous circulation and sufficient hemodynamic stability to undergo cardiac catheterization and revascularization. Read More

    Comparison of the effects of sternal and tibial intraosseous administered resuscitative drugs on return of spontaneous circulation in a swine model of cardiac arrest.
    Am J Disaster Med 2016 Summber;11(3):175-182
    Research Scientist, The Geneva Foundation for Military Medical Research, Tacoma, Washington; Adjunct Associate Professor of Nurse Anesthesia, Doctoral Program in Nurse Anesthesia, Midwestern University, Glendale, Arizona.
    Objective: Compare vasopressin, amiodarone, and epinephrine administration by sternal intraosseous (SIO), tibial intraosseous (TIO), and intravenous (IV) routes in a swine model of cardiac arrest.

    Design: Prospective, randomized, between subjects, experimental design.

    Setting: Laboratory. Read More

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