5,911 results match your criteria Ventilator Management


National Patterns in Surgical Management of Syndactyly: A Review of 956 Cases.

Hand (N Y) 2019 Feb 15:1558944719828003. Epub 2019 Feb 15.

1 Yale University School of Medicine, New Haven, CT, USA.

Purpose: Being one of the most common congenital hand malformations, syndactyly is repaired by orthopedic, plastic, and fellowship-trained general surgeons. Limited multi-institutional outcomes analyses regarding incidence, timing, and type of repair exist.

Methods: All syndactyly cases performed over a 5-year period from 2012-2016 were isolated from the National Surgical Quality Improvement Program Pediatric database. Read More

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http://dx.doi.org/10.1177/1558944719828003DOI Listing
February 2019

Perioperative Lung Protective Ventilatory Management During Major Abdominal Surgery: A Hungarian Nationwide Survey.

J Crit Care Med (Targu Mures) 2019 Jan 4;5(1):19-27. Epub 2019 Feb 4.

University of Szeged, Department of Anaesthesiology and Intensive Therapy, Szeged, Hungary.

Lung protective mechanical ventilation (LPV) even in patients with healthy lungs is associated with a lower incidence of postoperative pulmonary complications (PPC). The pathophysiology of ventilator-induced lung injury and the risk factors of PPCs have been widely identified, and a perioperative lung protective concept has been elaborated. Despite the well-known advantages, results of recent studies indicated that intraoperative LPV is still not widely implemented in current anaesthesia practice. Read More

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http://dx.doi.org/10.2478/jccm-2019-0002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369570PMC
January 2019

Natural evolution of ductus arteriosus with noninterventional conservative management in extremely preterm infants born at 23-28 weeks of gestation.

PLoS One 2019 13;14(2):e0212256. Epub 2019 Feb 13.

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

This study aimed to determine the natural course of patent ductus arteriosus (PDA) with noninterventional conservative management and whether the presence and/or prolonged duration of hemodynamically significant (HS) PDA increased the risk of mortality and morbidities in extremely preterm (EPT) infants. We retrospectively reviewed the medical records of EPT infants born at 23-28 weeks of gestation (n = 195) from January 2011 to June 2014, when PDA was managed with noninterventional conservative treatment. We stratified infants into three subgroups of 23-24, 25-26, and 27-28 weeks and analyzed the prevalence and natural evolution of HS PDA, defined as ventilator dependency and PDA size ≥2 mm. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212256PLOS
February 2019

Effects of chloride content of intravenous crystalloid solutions in critically ill adult patients: a meta-analysis with trial sequential analysis of randomized trials.

Ann Intensive Care 2019 Feb 13;9(1):30. Epub 2019 Feb 13.

Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, China.

Background: Intravenous crystalloid solutions are administered commonly for critically ill patients. We performed this meta-analysis of randomized trials with trial sequential analysis (TSA) to evaluate effects of chloride content of intravenous crystalloid solutions on clinical outcomes among critically ill adult patients.

Methods: Electronic databases were searched up to June 1, 2018, for randomized trials of use of balanced crystalloids versus 0. Read More

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http://dx.doi.org/10.1186/s13613-019-0506-yDOI Listing
February 2019

First experience with Tolvaptan for the treatment of neonates and infants with capillary leak syndrome after cardiac surgery.

BMC Pediatr 2019 Feb 12;19(1):57. Epub 2019 Feb 12.

Department of Pediatric Cardiology, University of Erlangen-Nürnberg, Loschgestrasse 15, 91054, Erlangen, Germany.

Background: Postoperative fluid management in critically ill neonates and infants with capillary leak syndrome (CLS) and extensive volume overload after cardiac surgery on cardiopulmonary bypass is challenging. CLS is often resistant to conventional diuretic therapy, aggravating the course of weaning from invasive ventilation, increasing length of stay on ICU and morbidity and mortality.

Methods: Tolvaptan (TLV, vasopressin type 2 receptor antagonist) was used as an additive diuretic in neonates and infants with CLS after cardiac surgery. Read More

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http://dx.doi.org/10.1186/s12887-019-1418-6DOI Listing
February 2019

Effects of Stepwise Lung Recruitment Maneuvers in Patients with Early Acute Respiratory Distress Syndrome: A Prospective, Randomized, Controlled Trial.

J Clin Med 2019 Feb 10;8(2). Epub 2019 Feb 10.

School of Medicine, College of Medicine, Fu Jen Catholic University, Xinzhuang Dist., New Taipei City 24205, Taiwan (R.O.C).

Since the clinical benefit of lung recruitment maneuvers (LRMs) is still conflicting, we performed this prospective, randomized, controlled study to investigate whether LRMs should be used in the routine management of acute respiratory distress syndrome (ARDS). This trial was conducted in four intensive care units (ICUs) to compare application of a modified stepwise LRMs with solely lung-protective ventilation in patients with moderate to severe ARDS within 72 h from the onset. The primary outcome was 28-day mortality, and the secondary outcomes were ventilator-free days and ICU-free days. Read More

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http://www.mdpi.com/2077-0383/8/2/231
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http://dx.doi.org/10.3390/jcm8020231DOI Listing
February 2019
3 Reads

Adverse Maternal and Fetal Outcome in Patients with Eclampsia.

J Nepal Health Res Counc 2019 Jan 28;16(41):425-427. Epub 2019 Jan 28.

Department of Obstetrics and Gynecology, BPKIHS, Dharan, Sunsari, Nepal.

Background: Eclampsia is a multisystem disorder that may lead to deterioration of maternal condition, hypoxia and acidosis of fetus. Objective was to evaluate the risk factors associated with adverse maternal and fetal outcome in patients with eclampsia.

Methods: All patients with eclampsia were enrolled after informed consent from February 2013 to February 2014. Read More

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January 2019
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Technological advances in home non-invasive ventilation monitoring: Reliability of data and effect on patient outcomes.

Respirology 2019 Feb 10. Epub 2019 Feb 10.

Normandie Univ, UNIRouen, EA3830-GRHV, Institute for Research and Innovation in Biomedicine (IRIB), Rouen, France.

Home non-invasive mechanical ventilation (NIV) has become a well-established treatment for patients with chronic hypercapnic respiratory failure. NIV monitoring has been developed to evaluate the effectiveness of mechanical ventilation on patient outcomes, with built-in systems providing data on compliance, leaks and respiratory parameters. Although these data seem intuitively useful, two main concerns have been raised in the literature: (i) are they reliable and (ii) to what extent does their use improve patient outcomes. Read More

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http://dx.doi.org/10.1111/resp.13497DOI Listing
February 2019
1 Read

Flow-controlled ventilation during ear, nose and throat surgery: A prospective observational study.

Eur J Anaesthesiol 2019 Feb 5. Epub 2019 Feb 5.

Hospital Sírio Libanês, São Paulo, Brazil.

Background: Flow-controlled ventilation (FCV) is a new mechanical ventilation mode that maintains constant flow during inspiration and expiration with standard tidal volumes via cuffed narrow-bore endotracheal tubes. Originating in manually operated 'expiratory ventilation assistance', FCV extends this technique by automatic control of airway flow, monitoring of intratracheal pressure and control of peak inspiratory pressure and end-expiratory pressure. FCV has not yet been described in a clinical study. Read More

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http://dx.doi.org/10.1097/EJA.0000000000000967DOI Listing
February 2019
2 Reads

New 5-Factor Modified Frailty Index Predicts Morbidity and Mortality in Geriatric Hip Fractures.

J Orthop Trauma 2019 Jan 30. Epub 2019 Jan 30.

Medical University of South Carolina Department of Orthopaedics 96 Jonathan Lucas Dr CSB 708 Charleston, SC 29425.

Introduction: While the 11-factor modified frailty index (mFI-11) has been shown to predict adverse outcomes in elderly patients undergoing surgery for hip fractures, the newer 5-factor index has not been evaluated in this population. The goal of this study is to evaluate the mFI-5 as a predictor of morbidity and mortality in elderly patients undergoing surgical management for hip fractures.

Methods: The NSQIP database was queried for patients aged 60 years and older who underwent surgical management for hip fractures between 2005-2016. Read More

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http://dx.doi.org/10.1097/BOT.0000000000001455DOI Listing
January 2019
1 Read

Effect of early and focused benzodiazepine therapy on length of stay in severe alcohol withdrawal syndrome.

Clin Toxicol (Phila) 2019 Feb 7:1-4. Epub 2019 Feb 7.

b Department of Surgery , University of California, Davis Medical Center , Sacramento , CA, USA.

Objective: Current evidence supports symptom-triggered therapy for alcohol withdrawal syndrome (AWS). Early, escalating therapy with benzodiazepines (BZD) appears to decrease ICU length of stay (LOS); however, the effect on hospital LOS remains unknown. The hypothesis of this study is that focused BZD treatment in the first 24 h will decrease hospital LOS. Read More

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http://dx.doi.org/10.1080/15563650.2018.1542701DOI Listing
February 2019
1 Read

Home mechanical ventilation for chronic obstructive pulmonary disease: What next after the HOT-HMV trial?

Respirology 2019 Feb 7. Epub 2019 Feb 7.

Lane Fox Respiratory Service, Guy's and St Thomas' NHS Foundation Trust, London, UK.

The benefits of acute non-invasive ventilation to treat acidotic exacerbations of chronic obstructive pulmonary disease (COPD) are well-established. Until recently, the evidence for home mechanical ventilation (HMV) to treat patients with stable COPD had been lacking. This has subsequently been addressed by the application of higher levels of pressure support combined with targeted management of chronic respiratory failure, which demonstrated a reduction in all-cause mortality. Read More

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http://dx.doi.org/10.1111/resp.13484DOI Listing
February 2019
2 Reads

Ventilatory and Pharmacotherapeutic Strategies for Management of Adult Patients on Extracorporeal Life Support.

Pharmacotherapy 2019 Feb 5. Epub 2019 Feb 5.

Division of Pulmonary, Allergy and Critical Care, Columbia University College of Physicians and Surgeons/NewYork-Presbyterian Hospital, New York, NY.

Extracorporeal life support (ECLS) can provide mechanical support for patients with severe, life-threating cardiac or respiratory failure. ECLS is a complex therapy that has increased in use over several decades owing to advances in technology. In concert with this growth, there is an increased need to understand the complexity of this technology to augment the effectiveness of ECLS and minimize complications such as ventilator-induced lung injury, bleeding, thrombosis, infections, and inadequate drug dosing. Read More

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http://dx.doi.org/10.1002/phar.2230DOI Listing
February 2019
3 Reads

Impact of spontaneous breathing during mechanical ventilation in acute respiratory distress syndrome.

Curr Opin Crit Care 2019 Jan 31. Epub 2019 Jan 31.

Department of Anesthesiology and Intensive Care Medicine, Osaka University Graduate School of Medicine, Suita, Japan.

Purpose Of Review: Facilitating spontaneous breathing has been traditionally recommended during mechanical ventilation in acute respiratory distress syndrome (ARDS). However, early, short-term use of neuromuscular blockade appears to improve survival, and spontaneous effort has been shown to potentiate lung injury in animal and clinical studies. The purpose of this review is to describe the beneficial and deleterious effects of spontaneous breathing in ARDS, explain potential mechanisms for harm, and provide contemporary suggestions for clinical management. Read More

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http://dx.doi.org/10.1097/MCC.0000000000000597DOI Listing
January 2019
8 Reads

[Current state of sedation, analgesia and blood glucose management in intensive care units of county hospitals: a multicenter cross-sectional survey in Guizhou Province of China].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2019 Jan;31(1):108-111

Department of Critical Care Medicine, the Affiliated Hospital of Guizhou Medical University, Guiyang 550004, Guizhou, China.

Objective: To investigate the current state of sedation, analgesia and blood glucose management in intensive care units (ICUs) of county hospitals in Guizhou Province of China, and to provide the evidences for improving quality control in critical care medicine.

Methods: In March 2018, 3-4 ICUs of hospitals in every prefecture (one hospital per county) in Guizhou Province were visited to do the field survey. The patients' nursing records within 24 hours after ICU admission were reviewed, and the information such as gender, age, major diagnosis at the ICU admission, the time of admission, were collected. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2019.01.021DOI Listing
January 2019
1 Read

Efficacy of new intermittent abdominal pressure ventilator for post-ischemic cervical myelopathy ventilatory insufficiency.

Multidiscip Respir Med 2019 28;14. Epub 2019 Jan 28.

3Department of Physical Medicine and Rehabilitation, Rutgers University New Jersey Medical School, Newark, USA.

Non-invasive ventilation (NIV) is the treatment of choice for patients symptomatic for respiratory muscle dysfunction. It can normalize gas exchange and provide up to continuous non-invasive ventilator support (CNVS) as an alternative to intubation and tracheotomy. It is usually provided via non-invasive facial interfaces or mouthpieces, but these can be uncomfortable and uncosmetic. Read More

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http://dx.doi.org/10.1186/s40248-019-0169-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348665PMC
January 2019
1 Read

The most frequent and important events that threaten patient safety in intensive care units from the perspective of health-care professionals'.

J Res Med Sci 2018 28;23:104. Epub 2018 Dec 28.

Department of Health Services Management, School of Health Management and Information Science, Iran University of Medical Sciences, Tehran, Iran.

Background: Patient safety is a priority in all health-care centers across the world. This study aimed to determine the frequency of events that threaten patient safety and the grade threating of events from the perspective of the health-care professionals in the intensive care units (ICUs).

Materials And Methods: This cross-sectional study was conducted in 2016. Read More

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http://dx.doi.org/10.4103/jrms.JRMS_140_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327678PMC
December 2018
1 Read

Prospective Hospital-Based Clinical and Electrophysiological Evaluation of Acute Organophosphate Poisoning.

Ann Indian Acad Neurol 2019 Jan-Mar;22(1):91-95

Department of Medicine, Jawaharlal Nehru Medical College and KLES Dr. Prabhakar Kore Hospital and MRC, Belagavi, Karnataka, India.

Introduction: Acute organophosphate (OP) poisoning is one of the most common poisoning causing significant morbidity and mortality in developing countries. Acute cholinergic manifestations predominate with many patients requiring intensive care management and ventilator support. Nerve conduction studies including repetitive nerve stimulation can evaluate the altered neuromuscular transmission and peripheral nerve function by OPs. Read More

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http://dx.doi.org/10.4103/aian.AIAN_137_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327708PMC
January 2019
1 Read

Screen printed potentiometric sensor for therapeutic monitoring of rocuronium at the point of care.

Talanta 2019 May 14;196:137-144. Epub 2018 Dec 14.

Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr ElـAini Street, Cairo 11562, Egypt.

Rocuronium bromide (ROC) is currently regarded as the 'gold-standard' in emergency medicine and anesthesia. Globally, millions of human beings are daily administered ROC at emergency settings where it is favored among all the neuromuscular blockers, particularly succinylcholine, for both its fast onset of action and short duration. However, it has been reported that 45% of patients in the post-anesthesia care unit are susceptible to residual postoperative paralysis, undesired ventilator effects and incomplete recovery after ROC administration. Read More

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http://dx.doi.org/10.1016/j.talanta.2018.12.040DOI Listing

Machine Learning and Data Analytics in Pervasive Health.

Methods Inf Med 2018 Sep 24;57(4):194-196. Epub 2019 Jan 24.

Introduction: This accompanying editorial provides a brief introduction to this focus theme, focused on "Machine Learning and Data Analytics in Pervasive Health".

Objective: The innovative use of machine learning technologies combining small and big data analytics will support a better provisioning of healthcare to citizens. This focus theme aims to present contributions at the crossroads of pervasive health technologies and data analytics as key enablers for achieving personalised medicine for diagnosis and treatment purposes. Read More

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http://dx.doi.org/10.1055/s-0038-1673243DOI Listing
September 2018
2 Reads

Long-Term Ventilation in Neuromuscular Patients: Review of Concerns, Beliefs, and Ethical Dilemmas.

Respiration 2019 Jan 24:1-12. Epub 2019 Jan 24.

Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Palermo, Italy.

Background: Noninvasive mechanical ventilation (NIV) is an effective treatment in patients with neuromuscular diseases (NMD) to improve symptoms, quality of life, and survival.

Summary: NIV should be used early in the course of respiratory muscle involvement in NMD patients and its requirements may increase over time. Therefore, training on technical equipment at home and advice on problem solving are warranted. Read More

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http://dx.doi.org/10.1159/000495941DOI Listing
January 2019
5 Reads

Healthcare utilization, medical costs and mortality associated with malnutrition in patients with chronic obstructive pulmonary disease: a matched cohort study.

Curr Med Res Opin 2019 Jan 24. Epub 2019 Jan 24.

d Department of Internal Medicine , National Taiwan University Hospital Hsin-Chu Branch , Hsinchu , Taiwan.

Objective: Although disease-related malnutrition has prognostic implications for patients with chronic obstructive pulmonary disease (COPD), its health-economic impact and clinical burdens are uncertain. We conducted a population-level study to investigate these questions.

Methods: We excerpted data relevant to malnutrition, prolonged mechanical ventilation, and medications from claims by 1,197,098 patients which were consistent with COPD and registered by the Taiwan National Health Insurance Administration between 2009 and 2013. Read More

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http://dx.doi.org/10.1080/03007995.2019.1574460DOI Listing
January 2019
1 Read

Population Pharmacokinetic Analyses for Plazomicin Using Pooled Data from Phase 1, 2, and 3 Clinical Studies.

Antimicrob Agents Chemother 2019 Jan 22. Epub 2019 Jan 22.

Institute for Clinical Pharmacodynamics, Inc., Schenectady, New York, USA.

Plazomicin is an aminoglycoside with activity against multidrug-resistant Enterobacteriaceae. Plazomicin is dosed on a mg/kg basis and administered by 30-min intravenous infusion every 24 h, with dose adjustments for renal impairment and body weight (BW) ≥125% of ideal BW. A population pharmacokinetic analysis was performed to identify patient factors that account for variability in pharmacokinetics and to determine if dose adjustments are warranted based on covariates. Read More

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http://dx.doi.org/10.1128/AAC.02329-18DOI Listing
January 2019
1 Read

Positive end-expiratory pressure titration with electrical impedance tomography and pressure-volume curve in severe acute respiratory distress syndrome.

Ann Intensive Care 2019 Jan 17;9(1). Epub 2019 Jan 17.

Institute of Technical Medicine, Furtwangen University, Villingen-Schwenningen, Germany.

Background: The study objective was to compare titration of positive end-expiratory pressure (PEEP) with electrical impedance tomography (EIT) and with ventilator-embedded pressure-volume loop in severe acute respiratory distress syndrome (ARDS).

Methods: We have designed a prospective study with historical control group. Twenty-four severe ARDS patients (arterial oxygen partial pressure to fractional inspired oxygen ratio, PaO/FiO < 100 mmHg) were included in the EIT group and examined prospectively. Read More

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http://dx.doi.org/10.1186/s13613-019-0484-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336593PMC
January 2019
1 Read

Temporary transvenous diaphragm pacing vs. standard of care for weaning from mechanical ventilation: study protocol for a randomized trial.

Trials 2019 Jan 17;20(1):60. Epub 2019 Jan 17.

Sorbonne Université, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique and AP-HP, Groupe Hospitalier Pitié-Salpêtrière Charles Foix, Service de Pneumologie et Réanimation Médicale du Département R3S, Paris, France.

Background: Mechanical ventilation (MV) is a life-saving technology that restores or assists breathing. Like any treatment, MV has side effects. In some patients it can cause diaphragmatic atrophy, injury, and dysfunction (ventilator-induced diaphragmatic dysfunction, VIDD). Read More

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https://trialsjournal.biomedcentral.com/articles/10.1186/s13
Publisher Site
http://dx.doi.org/10.1186/s13063-018-3171-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337771PMC
January 2019
6 Reads

Infant burns: A single institution retrospective review.

Burns 2019 Jan 8. Epub 2019 Jan 8.

Department of Paediatric Surgery, Red Cross War Memorial Children's Hospital and Faculty of Health Sciences, University of Cape Town, South Africa.

Thermal injuries amongst infants are common and a cause of significant mortality and morbidity in South Africa. This has been attributed to the lack of an enabling environment (poverty-related lack of safe living conditions) and the cognitive and physical developmental immaturity of infants, who depend on their surroundings and adults to keep them safe. This is a retrospective observational study of 548 infant admissions over 48 months. Read More

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http://dx.doi.org/10.1016/j.burns.2018.11.005DOI Listing
January 2019
2 Reads

On-table extubation in neonates undergoing anoplasty: an experience of anesthetic management on the concept of fast-tracking anesthesia: A pilot study.

Medicine (Baltimore) 2019 Jan;98(2):e14098

Department of Anesthesiology, Sichuan University West China Hospital.

Fast-track anesthesia (FTA) is difficult to achieve in neonates due to immature organ function and high rates of perioperative events. As a high-risk population, neonates require prolonged postoperative mechanical ventilation, which may lead to contradictions in cases where neonatal intensive care unit resources and ventilator facilities are limited. The choice of anesthesia strategy and anesthetic can help achieve rapid postoperative rehabilitation and save hospitalization costs. Read More

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http://dx.doi.org/10.1097/MD.0000000000014098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336589PMC
January 2019
7 Reads

Rib Fixation Versus Conservative Management Of Rib Fractures In Trauma Patients.

J Ayub Med Coll Abbottabad 2018 Oct-Dec;30(4):576-584

Department of Thoracic Surgery, CMH Lahore, Pakistan.

Background: 10-15 % of trauma patient has chest injuries. There is a paradigm shift in the last two decades towards rib fixation from conservative management. Rib fixation results in immediate pain reduction in patients. Read More

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January 2019
7 Reads

[Analysis of tracheal morphology by spiral CT in 126 cleft palate children].

Authors:
J J Li J Chu M Hu

Zhonghua Kou Qiang Yi Xue Za Zhi 2019 Jan;54(1):23-28

Department of General Surgery, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.

To discuss the surgical safeness of the cleft palate children with airway stenosis by means of analyzing characteristics of the shape of the upper airway and comparing clinical data of cleft palate children with airway stenosis and non-airway stenosis. Tracing back from Apirl 2015 to Apirl 2017, 126 cleft palate children treated in Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, were included (46 male and 80 female, age of 7 to 74 months, median age 18 months). According to the spiral CT scan of neck, patients were categorized to airway-stenosis group (65 patients) and non-airway-stenosis group (61 patients). Read More

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http://dx.doi.org/10.3760/cma.j.issn.1002-0098.2019.01.005DOI Listing
January 2019
1 Read

Ventilatory support after extubation in critically ill patients.

Lancet Respir Med 2018 Dec;6(12):948-962

University Department of Medical, Oral and Biotechnological Sciences, Gabriele d'Annunzio University of Chieti-Pescara, Chieti, Italy; Clinical Department of Anaesthesiology and Intensive Care Medicine, SS. Annunziata Hospital, Chieti, Italy.

The periextubation period represents a crucial moment in the management of critically ill patients. Extubation failure, defined as the need for reintubation within 2-7 days after a planned extubation, is associated with prolonged mechanical ventilation, increased incidence of ventilator-associated pneumonia, longer intensive care unit and hospital stays, and increased mortality. Conventional oxygen therapy is commonly used after extubation. Read More

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http://dx.doi.org/10.1016/S2213-2600(18)30375-8DOI Listing
December 2018
1 Read

Comparison of GeneXpert MRSA/SA ETA assay with semi-quantitative and quantitative cultures and gene-based qPCR for detection of in endotracheal aspirate samples.

Antimicrob Resist Infect Control 2019 5;8. Epub 2019 Jan 5.

1Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute, University of Antwerp, Universiteitsplein 1, D.S.6.23, 2610 Wilrijk, Belgium.

Introduction: is a common cause of ventilator-associated pneumonia. Rapid and accurate detection of lower respiratory tract colonization and/or infection with may inform targeted preventive and therapeutic strategies. To investigate this, we compared semi-quantitative (SQ)-culture results from 79 endotracheal aspirates (ETA) collected from mechanically-ventilated patients, to two culture and two non-culture-based methods for detection of . Read More

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http://dx.doi.org/10.1186/s13756-018-0460-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321727PMC
January 2019
1 Read

Neonatal bronchoscopy: Role in respiratory disease of the newborn-A 7 year experience.

Pediatr Pulmonol 2019 Jan 8. Epub 2019 Jan 8.

Discipline of Medical Biochemistry and Chemical Pathology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences University of KwaZulu-Natal, Durban, South Africa.

Background: Bronchoalveolar lavage (BAL) is a standardized method to obtain specimen samples from the airway lumen of the respiratory system. BAL is used to diagnose lung infection and infection markers in neonates.

Objectives: The aim was to evaluate the utility of flexible fiberoptic bronchoscopy in term and preterm neonates and to evaluate the use of BAL obtained by bronchoscopy in neonatal lung disease. Read More

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http://dx.doi.org/10.1002/ppul.24243DOI Listing
January 2019
2 Reads

Chemical pharmacotherapy for hospital-acquired pneumonia in the elderly.

Expert Opin Pharmacother 2019 Mar 7;20(4):423-434. Epub 2019 Jan 7.

a Infectious Diseases Department , University Hospital Vall d'Hebron, Autonomous University of Barcelona , Barcelona , Spain.

Introduction: Hospital-acquired pneumonia (HAP) is a potentially serious infection that primarily affects older patients. The number of patients affected by multidrug-resistant (MDR) bacteria is increasing, including infection from strains of Staphylococcus aureus, Enterobacteriaceae, and Pseudomonas aeruginosa. Areas covered: This article focuses specifically on HAP, excluding patients afflicted by ventilator-associated pneumonia (VAP). Read More

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https://www.tandfonline.com/doi/full/10.1080/14656566.2018.1
Publisher Site
http://dx.doi.org/10.1080/14656566.2018.1559820DOI Listing
March 2019
5 Reads

In vivo detection of endotracheal tube biofilms in intubated critical care patients using catheter-based optical coherence tomography.

J Biophotonics 2019 Jan 2:e201800307. Epub 2019 Jan 2.

Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois.

The formation of biofilms in the endotracheal tubes (ETTs) of intubated patients on mechanical ventilation is associated with a greater risk of ventilator-associated pneumonia and death. New technologies are needed to detect and monitor ETTs in vivo for the presence of these biofilms. Longitudinal OCT imaging was performed in mechanically ventilated subjects at 24-hour intervals until extubation to detect the formation and temporal changes of in vivo ETT biofilms. Read More

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http://dx.doi.org/10.1002/jbio.201800307DOI Listing
January 2019
2 Reads

Comparing current US and European guidelines for nosocomial pneumonia.

Curr Opin Pulm Med 2018 Dec 28. Epub 2018 Dec 28.

Department of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO), St James's Hospital, Dublin, Ireland.

Purpose Of Review: In the last 2 years, two major guidelines for the management of nosocomial pneumonia have been published: The International European Respiratory Society/European Society of Intensive Care Medicine/European Society of Clinical Microbiology and Infectious Diseases/Asociación Latinoamericana de Toráx guidelines for the management of hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) and the American guidelines for management of adults with HAP and VAP; both the guidelines made important clinical recommendations for the management of patients.

Recent Findings: With the increasing emergence of multidrug resistant (MDR) organisms, paired with a relative reduction in new antibiotic development, nosocomial infections have become one of the most significant issues affecting global healthcare today. Despite several stark differences between the European and American guidelines, they are in agreement about many aspects of nosocomial pneumonia management. Read More

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http://dx.doi.org/10.1097/MCP.0000000000000559DOI Listing
December 2018
2 Reads

The Right Ventricle During Selective Lung Ventilation for Thoracic Surgery.

J Cardiothorac Vasc Anesth 2018 Nov 22. Epub 2018 Nov 22.

University Hospitals Birmingham National Health Service Foundation Trust, Department of Critical Care Medicine, Queen Elizabeth Hospital Birmingham, Edgbaston, Birmingham, UK; Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, Centre of Translational Inflammation Research, University of Birmingham, Birmingham, UK.

The right ventricle (RV) has been an area of evolving interest after decades of being ignored and considered less important than the left ventricle. Right ventricular dysfunction/failure is an independent predictor of mortality and morbidity in cardiac surgery; however, very little is known about the incidence or impact of RV dysfunction/failure in thoracic surgery. The pathophysiology of RV dysfunction/failure has been studied in the context of acute respiratory distress syndrome (ARDS), cardiac surgery, pulmonary hypertension, and left ventricular failure, but limited data exist in literature addressing the issue of RV dysfunction/failure in the context of thoracic surgery and one-lung ventilation (OLV). Read More

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http://dx.doi.org/10.1053/j.jvca.2018.11.030DOI Listing
November 2018
2 Reads

[Effect of enteral nutrition tolerance assessment standardized process management on ventilator associated pneumonia and prognosis in patients with tracheotomy and long-term mechanical ventilation in intensive care unit].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Dec;30(12):1173-1177

Department of Cardiothoracic Surgery, Changzhou First People's Hospital, Changzhou 213003, Jiangsu, China. Corresponding author: Wang Bin, Email:

Objective: To investigate the effect of enteral nutrition (EN) tolerance assessment standardized process management on nosocomial infection and prognosis in patients with tracheotomy and long-term mechanical ventilation (MV) in intensive care unit (ICU).

Methods: A prospective cohort study was conducted. Forty-six patients who required long-term MV due to tracheotomy admitted to ICU of Changzhou First People's Hospital from January 2015 to December 2017 were enrolled. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2018.012.014DOI Listing
December 2018
4 Reads

REPEATED ANESTHESIA IN A BLACK RHINOCEROS ( DICEROS BICORNIS) TO MANAGE UPPER RESPIRATORY OBSTRUCTION.

J Zoo Wildl Med 2018 Dec;49(4):1041-1046

This report describes weekly repeated anesthesia in a 7-yr-old, 1,030 kg, female Eastern black rhinoceros ( Diceros bicornis michaeli), that was immobilized six times using a combination of 2 mg etorphine (0.002 mg/kg), 5 mg medetomidine (0.005 mg/kg), 25 mg midazolam (0. Read More

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http://dx.doi.org/10.1638/2018-0095.1DOI Listing
December 2018

Risk factors for ventilator-associated events: A prospective cohort study.

Am J Infect Control 2018 Dec 22. Epub 2018 Dec 22.

Department of Infection Control, West China Hospital, Sichuan University, Chengdu, China; Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.

Background: In January 2013, the Centers for Disease Control and Prevention released new surveillance definitions for ventilator-associated event (VAE) to replace ventilator-associated pneumonia (VAP) in adult patients. VAEs are associated with prolonged mechanical ventilation and hospital death, but little is known about their risk factors and how best to prevent them.

Methods: We compared VAE cases with non-VAE cases with regard to demographics, comorbidities, sedative exposures, opioids exposures, paralytic exposures, routes of nutrition, blood products, gastric retention, and fluid balance. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01966553183098
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http://dx.doi.org/10.1016/j.ajic.2018.09.032DOI Listing
December 2018
8 Reads
2.206 Impact Factor

New treatments of multidrug-resistant Gram-negative ventilator-associated pneumonia.

Ann Transl Med 2018 Nov;6(21):423

Department of Critical Care, National and Kapodistrian University of Athens, School of Medicine, Attikon University General Hospital, Athens, Greece.

Ventilator-associated pneumonia (VAP) remains an important clinical problem globally, being associated with significant morbidity and mortality. As management of VAP requires adequate and timely antibiotic administration, global emergence of antimicrobial resistance poses serious challenges over our ability to maintain this axiom. Development of antimicrobials against MDR Gram-negative pathogens has therefore emerged as a priority and some new antibiotics have been marketed or approach late stage of development. Read More

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http://dx.doi.org/10.21037/atm.2018.10.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275416PMC
November 2018
2 Reads

"The multimodal approach for ventilator-associated pneumonia prevention"-requirements for nationwide implementation.

Ann Transl Med 2018 Nov;6(21):420

Department of Critical Care, Hospital Clínico San Carlos, Madrid, Spain.

The multimodal approach for ventilator-associated pneumonia (VAP) prevention has been shown to be a successful strategy in reducing VAP rates in many intensive care units (ICU) in some countries. The simultaneous application of several measures or "bundles" to reduce VAP rates has achieved a higher impact than the progressive implementation of the individual interventions. The ultimate objective of recommendation bundles is their integration in the culture of routine healthcare of the staff in charge of ventilated patients for accomplished rates to persist over time. Read More

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http://dx.doi.org/10.21037/atm.2018.08.40DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275409PMC
November 2018
1 Read

Favorable outcome with early initiation of VV-ECMO for unilateral lung disease in children.

Respir Med Case Rep 2019 27;26:73-77. Epub 2018 Nov 27.

Children's Hospital of Illinois, OSF St Francis Medical Center, Peoria, IL, United States.

Unilateral lung diseases such as unilateral pneumonia, trauma or pulmonary hemorrhage can cause profound hypoxemic respiratory failure necessitating mechanical ventilation. These disorders are characterized by marked asymmetry in lung mechanics, with the affected lung having a lower compliance compared to the healthier lung, and management involves complex strategies such as simultaneous independent lung ventilation. However, such strategies can be challenging in pediatric populations due to technical limitations, and also lead to ventilator induced lung injury. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22130071183032
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http://dx.doi.org/10.1016/j.rmcr.2018.11.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277245PMC
November 2018
18 Reads

[Visualization studies on research status of the ventilator-associated pneumonia based on SinoMed database].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Nov;30(11):1029-1035

Department of Critical Care Medicine, Gansu Provincial People's Hospital, Lanzhou 730000, Gansu, China (Zhao J, Zhang LQ, Zhang DQ, Yuan Y); Gansu University of Traditional Chinese Medicine, Lanzhou 730000, Gansu, China (Zhao J, He TP, Gong D); Evidence-Based Medicine Center of Lanzhou University, Lanzhou 730000, Gansu, China (Tian JH). Corresponding author: Yuan Yuan, Email:

Objective: To survey the distribution pattern and subject domain knowledge of the literatures about ventilator-associated pneumonia (VAP).

Methods: Literatures about VAP published until December 2017 were identified in SinoMed database for statistics and analysis. The information of author, organization and province was extracted by BICOMS software for generating co-occurrence matrix, at the same time, the topic words were cluster analyzed by Gcluto software to generate topical visual surface maps and visualization matrices, and the current research hotspots were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2018.011.004DOI Listing
November 2018
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Clinical characteristics and antimicrobial resistance of pneumococcal isolates of pediatric invasive pneumococcal disease in China.

Infect Drug Resist 2018 26;11:2461-2469. Epub 2018 Nov 26.

Department of Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China,

Purpose: causes serious infections globally, including invasive pneumococcal disease (IPD). We analyze clinical features of pediatric IPD cases identified in China and antibiotic susceptibility of isolated pneumococcal strains.

Methods: Confirmed pediatric IPD patients were prospectively recruited to the study. Read More

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http://dx.doi.org/10.2147/IDR.S183916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6263219PMC
November 2018
1 Read

Usefulness of telemedicine for home ventilator-dependent children.

J Telemed Telecare 2018 Dec 11:1357633X18811751. Epub 2018 Dec 11.

2 Department of Paediatrics, Obstetrics and Ginecology, Universidad de Valencia, Spain.

Introduction: Medical care for ventilator-dependent children must avoid hospital confinement, which is detrimental to the patient, their family and Paediatric Intensive Care Unit. Our objective was to assess the role of telemedicine in facilitating early and permanent discharge of such patients to home care.

Methods: This was a prospective clinical study (2007-2017) in tracheotomised ventilator-dependent children. Read More

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http://dx.doi.org/10.1177/1357633X18811751DOI Listing
December 2018
1 Read

Diaphragm-protective mechanical ventilation.

Curr Opin Crit Care 2019 Feb;25(1):77-85

Interdepartmental Division of Critical Care Medicine, University of Toronto.

Purpose Of Review: Diaphragm dysfunction is common in mechanically ventilated patients and predisposes them to prolonged ventilator dependence and poor clinical outcomes. Mechanical ventilation is a major cause of diaphragm dysfunction in these patients, raising the possibility that diaphragm dysfunction might be prevented if mechanical ventilation can be optimized to avoid diaphragm injury - a concept referred to as diaphragm-protective ventilation. This review surveys the evidence supporting the concept of diaphragm-protective ventilation and introduces potential routes and challenges to pursuing this strategy. Read More

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http://dx.doi.org/10.1097/MCC.0000000000000578DOI Listing
February 2019
2 Reads

Detection and management of dyspnea in mechanically ventilated patients.

Curr Opin Crit Care 2019 Feb;25(1):86-94

Sorbonne Université, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique.

Purpose Of Review: In ICU patients, dyspnea is one of the most prominent and distressing symptom. We sought to summarize current data on the prevalence and prognostic influence of dyspnea in the ICU setting and to provide concise and useful information for dyspnea detection and management.

Recent Findings: As opposed to pain, dyspnea has been a neglected symptom with regard to detection and management. Read More

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http://dx.doi.org/10.1097/MCC.0000000000000574DOI Listing
February 2019
3 Reads

Functional status at listing predicts waitlist and posttransplant mortality in pediatric liver transplant candidates.

Am J Transplant 2018 Dec 1. Epub 2018 Dec 1.

Department of Medicine, UCSF, San Francisco, California.

Functional impairment is associated with mortality in adult liver transplant candidates. This has not been studied in pediatric liver transplant candidates. United Network for Organ Sharing Standard Transplant Analysis and Research files were used to investigate functional status, waitlist mortality, and posttransplant outcomes in children younger than 18 years who were waitlisted in 2006-2016 for primary liver transplant. Read More

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http://dx.doi.org/10.1111/ajt.15203DOI Listing
December 2018
9 Reads