59,732 results match your criteria Ventilation Mechanical


Lidocaine reinforces the anti-inflammatory action of dexamethasone on myeloid and epithelial cells activated by inflammatory cytokines or SARS-CoV-2 infection.

Biomed J 2022 Aug 7. Epub 2022 Aug 7.

Instituto de Estudios Inmunológicos y Fisiopatológicos, Facultad de Ciencias Exactas, Universidad Nacional de La Plata. CONICET. Asociado CIC PBA. Boulevard 120 y 62 (1900), La Plata, Buenos Aires, Argentina. Electronic address:

Background: Severe cases of COVID-19 that require admission to the ICU and mechanical ventilation assistance show a high mortality rate with currently few therapeutic options available. Severe COVID-19 is characterized by a systemic inflammatory condition, also called "cytokine storm", which can lead to various multi-organ complications and ultimately death. Lidocaine, a safe local anesthetic that given intravenously is used to treat arrhythmias, has long been reported to have an anti-inflammatory and pro-homeostatic activity. Read More

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Clinical Results and Quality of Life after Nonelective Cardiac Surgery in Octogenarians.

Thorac Cardiovasc Surg 2022 Aug 16;70(5):384-391. Epub 2021 Jul 16.

Department of Cardiac Surgery, Ludwig Maximilian University of Munich, Germany.

Background:  We analyzed the short-term and mid-term outcomes as well as the health-related quality of life (HRQOL) of octogenarians undergoing elective and urgent cardiac surgery.

Patients And Methods:  We retrospectively identified 688 consecutive octogenarians who underwent cardiac surgery at our center between January 2012 and December 2019. A propensity score matching was performed which resulted in the formation of 80 matched pairs. Read More

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Prevalence of Gastrointestinal Symptoms and Clinical Outcomes in Hospitalized Coronavirus Disease 2019 Patients: A Single-Center Study from Turkey.

Turk J Gastroenterol 2022 Aug 10. Epub 2022 Aug 10.

Department of Gastroenterology, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey.

Background: In patients with coronavirus disease 2019, the gastrointestinal symptoms have been reported increasingly in addition to the respiratory system symptoms. The studies show that the prevalence of gastrointestinal system symptoms and how the gastrointestinal system contributes to the severity and prognosis of the disease is still not clear. This study aims to find the prevalence of gastrointestinal symptoms and the correlation between the gastrointestinal symptoms and the clinical results in hospitalized patients diagnosed with coronavirus disease 2019. Read More

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Posterior reversible encephalopathy syndrome in a child with severe multisystem inflammatory syndrome due to COVID-19.

Rev Bras Ter Intensiva 2022 Apr-Jun;34(2):295-299

Departamento de Pediatria, Instituto Nacional de Salud del Niño - Lima, Peru.

Posterior reversible encephalopathy syndrome is a rare clinical and radiological syndrome characterized by vasogenic edema of the white matter of the occipital and parietal lobes, which are usually symmetrical, resulting from a secondary manifestation of acute dysfunction of the posterior cerebrovascular system. We describe a case of posterior reversible encephalopathy syndrome secondary to SARS-CoV-2 infection in a 9-year-old boy who developed acute hypoxemic respiratory failure and required assisted mechanical ventilation. The child developed multisystem inflammatory syndrome, and he was monitored in the pediatric intensive care unit and was provided mechanical ventilation and vasoactive agents for hemodynamic support. Read More

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October 2021

Current stage of the intensive care unit structure in Argentina: results from the Sociedad Argentina de Terapia Intensiva self-assessment survey of intensive care units.

Rev Bras Ter Intensiva 2022 Apr-Jun;34(2):237-246

Comité de Gestión, Calidad y Datos, Sociedad Argentina de Terapia Intensiva - Buenos Aires, Argentina.

Objective: To describe and compare the structure of Argentinean intensive care units that completed the "self-assessment survey of intensive care units" developed by the Sociedad Argentina de Terapia Intensiva.

Methods: An observational crosssectional study was conducted using an online voluntary survey through the Sociedad Argentina de Terapia Intensiva member database and other social media postings. Answers received between December 2018 and July 2020 were analyzed. Read More

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October 2021

Influence of mechanical power and its components on mechanical ventilation in SARS-CoV-2.

Rev Bras Ter Intensiva 2022 Apr-Jun;34(2):212-219

Universidade Tecnológica Federal do Paraná - Curitiba (PR), Brasil.

Objective: To analyze the influence of mechanical power and its components on mechanical ventilation for patients infected with SARS-CoV-2; identify the values of the mechanical ventilation components and verify their correlations with each other and with the mechanical power and effects on the result of the Gattinoni-S and Giosa formulas.

Methods: This was an observational, longitudinal, analytical and quantitative study of respirator and mechanical power parameters in patients with SARS-CoV-2.

Results: The mean mechanical power was 26. Read More

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Characterizing the third wave of COVID-19: An analysis from the National Clinical Registry of COVID-19.

Indian J Med Res 2022 Aug 10. Epub 2022 Aug 10.

Indian Council of Medical Research, New Delhi, India.

Background & Objectives: Data from the National Clinical Registry for COVID-19 (NCRC) were analyzed with an aim to describe the clinical characteristics, course and outcomes of patients hospitalized with COVID-19 in the third wave of the pandemic and compare them with patients admitted earlier.

Methods: The NCRC, launched in September 2020, is a multicentre observational initiative, which provided the platform for the current investigation. Demographic, clinical, treatment and outcome data of hospitalized COVID-19 patients were captured in an electronic data portal from 38 hospitals across India. Read More

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Development of a cost-effective lung perfusion system for lung transplantation in India.

Indian J Med Res 2022 Feb;155(2):293-300

Department of Anaesthesia & Intensive Care, Advanced Cardiac Centre, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

Background & Objectives: Standard donor lung preservation with cold flush and storage allows up to six hours between retrieval of lungs from the donor and transplantation in the recipient. Ex vivo lung perfusion (EVLP) systems mimic physiological ventilation and perfusion in the donor lungs with potential for prolonged lung preservation and donor lung reconditioning. In this study, it was aimed to perform EVLP on discarded donor lungs using a locally developed EVLP system. Read More

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February 2022

Multisystem inflammatory syndrome-neonates (MIS-N) associated with acute kidney injury: A case report.

Trop Doct 2022 Aug 9:494755221114327. Epub 2022 Aug 9.

Neonatal and Pediatric Intensive Care Services, 468688Surya Mother and Child Care Superspecialty Hospital, Pune, India.

A late preterm presented with multisystem involvement (respiratory failure, shock, acute kidney injury). Initially, the baby was managed with mechanical ventilation, inotropic support, antibiotics, fluid restriction and furosemide infusion. Despite conservative management for 12 h, urine output, metabolic status and renal function did not improve; peritoneal dialysis was therefore commenced. Read More

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Recovery of skeletal muscle strength and physical function in a patient with (post) COVID-19 requiring extra-corporeal membrane oxygenation.

Physiother Theory Pract 2022 Aug 9:1-7. Epub 2022 Aug 9.

Department of Physical Therapy, Leiden University Medical Center, Leiden, Netherlands.

Background: The ongoing coronavirus-19 disease (COVID-19) has taught us that early mobilization is essential for functional recovery during and after prolonged intensive care unit (ICU) stay. This especially applies for patients receiving a challenging combination of prolonged invasive treatments such as mechanical ventilation (MV) and extra-corporeal membrane oxygenation (ECMO). This case report describes the recovery of skeletal muscle strength and physical function in a patient (post) COVID-19 during ICU stay. Read More

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Liquid Ventilation Reconditions Isolated Rat Lungs Following Ischemia Reperfusion Injury.

Tissue Eng Part A 2022 Aug 9. Epub 2022 Aug 9.

Harvard Medical School, Thoracic Surgery, 55 Fruit Street, Founders 7, Boston, Massachusetts, United States, 02115;

Lung transplantation remains the only curative treatment for end stage pulmonary disease. Lung ischemia-reperfusion injury (IRI) is a major contributor to primary allograft dysfunction and donor organ non-utilization. The alveolar macrophage is a key inflammatory mediator in IRI. Read More

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Outcome of Pregnant Patients with Cardiac Diseases Delivered in Tribhuvan University Teaching Hospital.

J Nepal Health Res Counc 2022 Jun 2;20(1):108-114. Epub 2022 Jun 2.

Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal.

Background: Pregnant women with cardiac disease pose a unique challenge to both the anaesthesiologists and obstetrician because of high morbidity affecting the maternal and fetal outcomes. Our research aims to provide an overview of pregnant women with heart disease coming for delivery in Tribhuvan University Teaching Hospital over one year, the occurrence of adverse maternal and neonatal outcome (mortality and morbidity) and correlation of certain maternal factors associated with adverse outcome.

Methods: This is an observational cross-sectional study conducted in Tribhuvan University Teaching Hospital from 2075/11/01 to 2076/10/30 where data of pregnant women beyond 28 wks period of gestation with diagnosed cardiac disease was recorded from secondary sources. Read More

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Efficacy and safety of permissive hypercapnia in preterm infants: A systematic review.

Pediatr Pulmonol 2022 Aug 9. Epub 2022 Aug 9.

Division of Neonatology, Center for Maternal-Fetal Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan.

Context: In adults, permissive hypercapnia reducesmortality and ventilation duration. However, in preterm infants, the findings from past research regarding the efficacy and safety of permissive hypercapnia are controversial.

Objective: To evaluate the efficacy and safety of permissive hypercapniaversusnormocapnia in preterm infants on mechanical ventilation. Read More

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Development and validation of a prognostic nomogram among patients with acute exacerbation of chronic obstructive pulmonary disease in intensive care unit.

BMC Pulm Med 2022 Aug 9;22(1):306. Epub 2022 Aug 9.

Department of Nursing, Shanghai Baoshan Luodian Hospital, 121 Luoxi Road, Baoshan District, Shanghai, 201908, China.

Background: Acute exacerbation of Chronic Obstructive Pulmonary Disease (AECOPD) contributes significantly to mortality among patients with COPD in Intensive care unit (ICU). This study aimed to develop a nomogram to predict 30-day mortality among AECOPD patients in ICU.

Methods: In this retrospective cohort study, we extracted AECOPD patients from Medical Information Mart for Intensive Care III (MIMIC-III) database. Read More

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Sex-specific treatment characteristics and 30-day mortality outcomes of critically ill COVID-19 patients over 70 years of age-results from the prospective COVIP study.

Can J Anaesth 2022 Aug 9. Epub 2022 Aug 9.

Department of Cardiology, Pulmonology and Vascular Medicine, Heinrich-Heine-University Düsseldorf, Medical Faculty, Düsseldorf, Germany.

Purpose: Older critically ill patients with COVID-19 have been the most vulnerable during the ongoing pandemic, with men being more prone to hospitalization and severe disease than women. We aimed to explore sex-specific differences in treatment and outcome after intensive care unit (ICU) admission in this cohort.

Methods: We performed a sex-specific analysis in critically ill patients ≥ 70 yr of age with COVID-19 who were included in the international prospective multicenter COVIP study. Read More

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Utility of myxedema score as a predictor of mortality in myxedema coma.

J Endocrinol Invest 2022 Aug 10. Epub 2022 Aug 10.

Department of Endocrinology, Post Graduate Institute of Medical Education and Research (PGIMER), Nehru Extension Block, 1012, Chandigarh, 160012, India.

Objective: Myxedema crisis (MC) is a rare condition. There is a dearth of data regarding the predictors of mortality in MC. Predictive scores for mortality specific to the clinical and biochemical profile of MC are still lacking. Read More

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Respiratory indications for ECMO: focus on COVID-19.

Intensive Care Med 2022 Aug 9. Epub 2022 Aug 9.

Columbia University College of Physicians and Surgeons/New York-Presbyterian Hospital, 622W168th St, PH 8 East, Room 101, New York, NY, 10032, USA.

Extracorporeal membrane oxygenation (ECMO) is increasingly being used for patients with severe respiratory failure and has received particular attention during the coronavirus disease 2019 (COVID-19) pandemic. Evidence from two key randomized controlled trials, a subsequent post hoc Bayesian analysis, and meta-analyses support the interpretation of a benefit of ECMO in combination with ultra-lung-protective ventilation for select patients with very severe forms of acute respiratory distress syndrome (ARDS). During the pandemic, new evidence has emerged helping to better define the role of ECMO for patients with COVID-19. Read More

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Effects of mild obesity on outcomes in Japanese patients with COVID-19: a nationwide consortium to investigate COVID-19 host genetics.

Nutr Diabetes 2022 Aug 9;12(1):38. Epub 2022 Aug 9.

Division of Health Medical Intelligence, Human Genome Center, the Institute of Medical Science, the University of Tokyo, Tokyo, Japan.

Background: Obesity is reported to be a risk factor for severe disease in patients with coronavirus disease 2019 (COVID-19). However, there are no specific reports on the risk of severe disease according to body mass index (BMI) in Japan. Thus, this study aimed to investigate the effect of obesity stratified by BMI on the severity of COVID-19 in the general Japanese population. Read More

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Associated microbiota and treatment of severe fever with thrombocytopenia syndrome complicated with infections.

J Med Virol 2022 Aug 9. Epub 2022 Aug 9.

Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.

Objective: The purpose of this study is to assess the incidence and management of co-infections in hospitalized severe fever with thrombocytopenia syndrome bunyavirus (SFTSV) patients.

Methods: We retrospectively evaluated the microbiological database records of the SFTS patients in the first affiliated hospital of Anhui Medical University from January 1, 2018, to December 1, 2021.

Results: According to the obtained results, co-infections including pulmonary infection, bloodstream infection, biliary tract infection, urinary tract infection, and abdominal infection were observed in SFTS patients. Read More

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The Lived Experience of Respiratory Therapists During Withdrawal of Advanced Life-Sustaining Therapies at End of Life in the ICU.

Respir Care 2022 Aug 9. Epub 2022 Aug 9.

San Diego State University, School of Nursing, San Diego, California. Ms Cutler is affiliated with University of California, San Diego Medical Center, San Diego, California.

Background: The act of withdrawing advanced life-sustaining therapies, more specifically mechanical ventilation, is performed in hospitals all over the world. Success involves coordination of several members of the patient care team, including nurses, providers (physicians nurse practitioners, or physician assistants), and respiratory therapists (RTs). The experiences of RTs surrounding this procedure are not well documented. Read More

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Association among myocardial injury and mortality in Influenza: A prospective cohort study.

Int J Cardiol 2022 Aug 6. Epub 2022 Aug 6.

Department of Biomedical Sciences, Università della Svizzera Italiana, Lugano, Switzerland; Division of Cardiology, Cardiocentro Ticino Institute, Ente Ospedaliero Cantonale, Lugano, Switzerland. Electronic address:

Background: Myocardial injury (MINJ) is a well-recognized prognostic marker in different acute cardio-respiratory illnesses, nonetheless, its relevance in Influenza remains poorly defined. Our aim was to assess incidence, correlates, short and mid-term prognostic role of MINJ in Influenza.

Methods: Hospitalized patients (pts) with laboratory confirmed Influenza A or B underwent highly sensitive cardiac T Troponin (hs-cTnT) measurement at admission in four regional Swiss hospitals during the 2018-2019 epidemic. Read More

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Immature platelet fraction as a biomarker for disease severity in pediatric respiratory Coronavirus Disease 2019.

J Pediatr 2022 Aug 6. Epub 2022 Aug 6.

Department of Pediatrics, Division of Hematology/Oncology, University of Texas Southwestern Medical Center, Dallas, TX, 75390. Electronic address:

In this retrospective single-institution cohort study of 113 hospitalized pediatric patients with respiratory Coronavirus Disease 2019 (COVID-19), those admitted to the intensive care unit or requiring mechanical ventilation had significantly higher immature platelet fractions (IPF) than those who did not require ICU-level care or ventilation. IPF may be an accessible biomarker for disease severity in pediatric respiratory COVID-19. Read More

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Healthy nonobese bitches maintain acceptable spontaneous ventilation during laparoscopic ovariectomies.

J Am Vet Med Assoc 2022 Jul 1:1-7. Epub 2022 Jul 1.

1Eastcott Referrals, Swindon, UK.

Objective: To determine whether end-tidal CO2 (Petco2), tidal volume (Vt), inspiratory minute volume (V.i), and respiratory rate (RR) remain within reference limits for spontaneously breathing dogs undergoing laparoscopic ovariectomy; characterize changes in these variables over time; and record the proportion of dogs requiring mechanical ventilation on the basis of predetermined criteria.

Animals: 22 client-owned dogs. Read More

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Impact of Ventricular Arrhythmia on LVAD Implantation Admission Outcomes.

Artif Organs 2022 Aug 9. Epub 2022 Aug 9.

Division of Cardiology, Jefferson Heart Institute, Thomas Jefferson University Hospital, Philadelphia, PA, USA.

Introduction: Ventricular arrhythmias (VAs) are common after left ventricular assist device (LVAD) implantation though data are mixed on whether these events have an impact on mortality.

Methods: The National Inpatient Sample (NIS) database from 2002 - 2019 was queried for LVAD implantation admissions. Secondary ICD codes were analyzed to assess for the occurrence of VAs during this admission. Read More

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Association of Administration of Surfactant Using Less Invasive Methods With Outcomes in Extremely Preterm Infants Less Than 27 Weeks of Gestation.

JAMA Netw Open 2022 Aug 1;5(8):e2225810. Epub 2022 Aug 1.

Department of Paediatrics, University Hospital Schleswig-Holstein/Campus Lübeck, Lübeck, Germany.

Importance: The inclusion of less invasive surfactant administration (LISA) in the care of preterm infants has been found to be beneficial for respiratory outcomes. Recently, the OPTIMIST trial found higher mortality rates in the subgroup of infants born at 25 to 26 weeks' gestational age (GA) who received surfactant treatment while spontaneously breathing.

Objective: To analyze outcomes among LISA-exposed, highly vulnerable babies born at less than 27 weeks' GA within the large-scale observational cohort of the German Neonatal Network. Read More

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Extracorporeal carbon dioxide removal for acute respiratory failure: a review of potential indications, clinical practice and open research questions.

Intensive Care Med 2022 Aug 9. Epub 2022 Aug 9.

PhyMedExp, University of Montpellier, Institut National de La Santé Et de La Recherche Médicale (INSERM), Centre National de La Recherche Scientifique (CNRS), Centre Hospitalier Universitaire (CHU) Montpellier, Montpellier, France.

Extracorporeal carbon dioxide removal (ECCOR) is a form of extracorporeal life support (ECLS) largely aimed at removing carbon dioxide in patients with acute hypoxemic or acute hypercapnic respiratory failure, so as to minimize respiratory acidosis, allowing more lung protective ventilatory settings which should decrease ventilator-induced lung injury. ECCOR is increasingly being used despite the lack of high-quality evidence, while complications associated with the technique remain an issue of concern. This review explains the physiological basis underlying the use of ECCOR, reviews the evidence regarding indications and contraindications, patient management and complications, and addresses organizational and ethical considerations. Read More

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In-Hospital Left Ventricular Assist Devices Deactivation and Death Experience: a Single-Institution Retrospective Analysis.

ASAIO J 2022 Jan 19. Epub 2022 Jan 19.

Section of Palliative Medicine, Department of Medicine, MedStar Washington Hospital Center, Washington, DC.

Best practices for left ventricular assist devices (LVADs) deactivation at end-of-life (EOL) have yet to be elucidated. We conducted a single-institution retrospective review of patients who died following LVAD deactivation between January 2017 and March 2020. Data were obtained from institutional databases and electronic health record and were analyzed using descriptive statistics. Read More

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January 2022

Factors associated with prolonged weaning from mechanical ventilation in medical patients.

Ther Adv Respir Dis 2022 Jan-Dec;16:17534666221117005

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea.

Background: Patients who need prolonged mechanical ventilation (MV) have high resource utilization and relatively poor outcomes. The pathophysiologic mechanisms leading to weaning failure in this group may be complex and multifactorial. The aim of this study was to investigate the factors associated with prolonged weaning based on the Weaning Outcome according to a New Definition (WIND) classification. Read More

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Severity of Disease and COVID-19 Complications During Hospital Stay: A Prospective Cohort Study.

Arch Iran Med 2022 Jun 1;25(6):383-393. Epub 2022 Jun 1.

Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: COVID-19, with its high transmission and mortality rates and unknown outcomes, has become a major concern in the world. Among people with COVID-19, severe cases can quickly progress to serious complications, and even death. So, the present study aimed to examine the relationship between the severity of the disease and the outcome in patients afflicted by COVID-19 during hospitalization. Read More

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