53,673 results match your criteria Ventilation Mechanical

Model-based estimation of negative inspiratory driving pressure in patients receiving invasive NAVA mechanical ventilation.

Comput Methods Programs Biomed 2021 Jul 22;208:106300. Epub 2021 Jul 22.

Department of Intensive Care, Christchurch Hospital, Private Bag 4710, Christchurch, New Zealand.

Background: Optimisation of mechanical ventilation (MV) and weaning requires insight into underlying patient breathing effort. Current identifiable models effectively describe lung mechanics, such as elastance (E) and resistance (R) at the bedside in sedated patients, but are less effective when spontaneous breathing is present. This research derives and regularises a single compartment model to identify patient-specific inspiratory effort. Read More

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Impact of early corticosteroids on 60-day mortality in critically ill patients with COVID-19: A multicenter cohort study of the OUTCOMEREA network.

PLoS One 2021 4;16(8):e0255644. Epub 2021 Aug 4.

Université de Paris, UMR 1137, IAME, Paris, France.

Objectives: In severe COVID-19 pneumonia, the appropriate timing and dosing of corticosteroids (CS) is not known. Patient subgroups for which CS could be more beneficial also need appraisal. The aim of this study was to assess the effect of early CS in COVID-19 pneumonia patients admitted to the ICU on the occurrence of 60-day mortality, ICU-acquired-bloodstream infections(ICU-BSI), and hospital-acquired pneumonia and ventilator-associated pneumonia(HAP-VAP). Read More

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Acute ICU Resuscitation of Severely Injured Trauma Patients: Do We Need a New Strategy?

J Trauma Acute Care Surg 2021 Aug 3. Epub 2021 Aug 3.

Department of Surgery, Harborview Medical Center, University of Washington, Washington. Harborview Injury Prevention and Research Center, Harborview Medical Center, University of Washington, Washington.

Background: Unlike recent advances in blood product resuscitation, crystalloid (IVF) use after ICU admission in hemorrhagic shock has received less attention and current recommendations are based on limited evidence. To address this knowledge gap, we aimed to determine associations between IVF administration during acute ICU resuscitation and outcomes. We hypothesized that larger IVF volumes are associated with worse outcomes. Read More

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Percutaneous Tracheostomy in Respiratory Failure Due to COVID-19.

J Bronchology Interv Pulmonol 2021 Aug 4. Epub 2021 Aug 4.

Department of Pulmonary and Critical Care Medicine Procedure Center, Cedars-Sinai Medical Center, Los Angeles, CA.

Background: Coronavirus disease 2019 (COVID-19) can lead to hypoxemic respiratory failure resulting in prolonged mechanical ventilation. Typically, tracheostomy is considered in patients who remain ventilator dependent beyond 2 weeks. However, in the setting of this novel respiratory virus, the safety and benefits of tracheostomy are not well-defined. Read More

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Identifying the Risk Factors for Mortality in Patients with Cancer and COVID-19 in Hamadan, the West of Iran.

J Gastrointest Cancer 2021 Aug 4. Epub 2021 Aug 4.

Department of Biostatistics, School of Public Health, Modeling of Noncommunicable Diseases Research Canter, Hamadan University of Medical Sciences, Hamadan, Iran.

Purpose: Since cancer patients are at higher risk of COVID-19, the present study was conducted to investigate the epidemiology of these patients and identify the affecting risk factors on their mortality.

Methods: The present retrospective cohort study was conducted on 66 hospitalized patients with cancer and COVID-19 in Hamadan in 2020. In the present study, demographic, clinical, and laboratory information and patients' outcome were collected through a checklist and its impact on death was assessed. Read More

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Effectiveness of favipiravir in COVID-19: a live systematic review.

Eur J Clin Microbiol Infect Dis 2021 Aug 4. Epub 2021 Aug 4.

School of Medicine, Koç University, Istanbul, Turkey.

We performed a systematic review and meta-analysis for the effectiveness of Favipiravir on the fatality and the requirement of mechanical ventilation for the treatment of moderate to severe COVID-19 patients. We searched available literature and reported it by using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Until June 1, 2021, we searched PubMed, bioRxiv, medRxiv, ClinicalTrials. Read More

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Association Between Self-reported Importance of Religious or Spiritual Beliefs and End-of-Life Care Preferences Among People Receiving Dialysis.

JAMA Netw Open 2021 Aug 2;4(8):e2119355. Epub 2021 Aug 2.

US Department of Veterans Affairs (VA) Health Services Research and Development Center of Innovation, VA Puget Sound Health Care System, Seattle, Washington.

Importance: Although people receiving maintenance dialysis have limited life expectancy and a high burden of comorbidity, relatively few studies have examined spirituality and religious beliefs among members of this population.

Objective: To examine whether there is an association between the importance of religious or spiritual beliefs and care preferences and palliative care needs in people who receive dialysis.

Design, Setting, And Participants: A cross-sectional survey study was conducted among adults who were undergoing maintenance dialysis at 31 facilities in Seattle, Washington, and Nashville, Tennessee, between April 22, 2015, and October 2, 2018. Read More

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Interleukin 17 antagonist netakimab is effective and safe in the new coronavirus infection (COVID-19).

Eur Cytokine Netw 2021 Mar;32(1):8-14

Department of Internal Medicine, Gastroenterology and Hepatology, Sechenov University, Pogodinskaya str., 1, bld. 1, Moscow, 119435, Russian Federation.

Cytokine release syndrome is a serious complication of the new coronavirus infection (COVID-19). The aim of the study was to assess effectiveness and safety of the IL-17 antagonist nekatimab for its treatment. The retrospective study included COVID-19 patients with C-reactive protein levels >60 mg/L. Read More

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Admission NT-proBNP and outcomes in patients without history of heart failure hospitalized with COVID-19.

ESC Heart Fail 2021 Aug 4. Epub 2021 Aug 4.

Division of Cardiology, Department of Medicine, Stony Brook University, Stony Brook, NY, USA.

Aims: We examined the value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients admitted for coronavirus disease 2019 (COVID-19) without prior history of heart failure (HF) or cardiomyopathy.

Methods And Results: Retrospective cohort of consecutive adults (N = 679; median age 59 years; 38.7% women; 87. Read More

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A Quality Improvement Approach to Influence Value-based Mucolytic Use in the PICU.

Pediatr Qual Saf 2021 Jul-Aug;6(4):e438. Epub 2021 Jul 28.

Division of Pediatric Critical Care Medicine, Department of Pediatrics, The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, Ohio.

Introduction: High-cost medication administration, despite lacking evidence for use, results in poor healthcare value. This work aimed to reduce dornase-alfa utilization in critically ill mechanically ventilated children.

Methods: The project employed an observational pre-post design to develop a value-based clinical pathway to guide provider choice in mucolytic utilization in a quaternary pediatric intensive care unit. Read More

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High Risk Coronavirus Disease 2019: The Primary Results of the CoronaHeart Multi-Center Cohort Study.

Int J Cardiol Heart Vasc 2021 Jul 30:100853. Epub 2021 Jul 30.

Heart Institute (InCor), Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

Background: Patients with Coronavirus Disease 2019 (COVID-19) may present high risk features, including cardiovascular manifestations, during hospitalization. However, less is known about the factors that may further increase the risk of death in these patients.

Methods: We included patients with COVID-19 and high risk features according to clinical and/or laboratory criteria at 21 sites in Brazil from June 10 to October 23 of 2020. Read More

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High-Frequency Percussive Ventilation in Cystic Fibrosis Patients With Acute Respiratory Failure: A Case Series.

Cureus 2021 Jul 1;13(7):e16087. Epub 2021 Jul 1.

Pulmonary and Critical Care Medicine, The University of Kansas Health System, Kansas City, USA.

Acute respiratory failure in cystic fibrosis carries a high risk of mortality. The optimal mode of mechanical ventilation (MV) in this population is not well established. In this case series, we identified patients with cystic fibrosis who were ventilated with high-frequency percussive ventilation (HFPV) at our institution and describe their characteristics and outcomes. Read More

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Coronavirus disease 2019 infection and pituitary apoplexy: A causal relation or just a coincidence? A case report and review of the literature.

Surg Neurol Int 2021 28;12:317. Epub 2021 Jun 28.

Department of Neurosurgery, Ibn Sina Hospital, Al-Sabah Medical Area, Kuwait.

Background: Pituitary tumor apoplexy (PA) is an emergency condition caused by hemorrhage or infarction of the preexisting adenoma. Many factors are currently well-known to predispose to PA. However, during the period of coronavirus disease 2019 (COVID-19) pandemic, case reports of PA associated with COVID-19 infection have been sequentially published. Read More

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Factors associated with treatment failure of high-flow nasal cannula among children with bronchiolitis: a single-centre retrospective study.

Paediatr Child Health 2021 Aug 2;26(5):e229-e235. Epub 2020 Aug 2.

Department of Pediatrics, McMaster University, Hamilton, Ontario.

Objectives: Bronchiolitis is the most common viral lower respiratory tract infection in children under age 2 for which high-flow nasal cannula (HFNC) is increasingly used. Understanding factors associated with HFNC failure is important to identify patients at risk for respiratory deterioration. The objective of this study was to evaluate patient characteristics associated with HFNC failure in bronchiolitis. Read More

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Hemoperfusion in patients with severe COVID-19 respiratory failure, lifesaving or not?

J Res Med Sci 2021 27;26:34. Epub 2021 May 27.

Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: The new coronavirus outbreak quickly filled hospital beds and stunned the world. Intensive care is required for 5% of patients, and the mortality rate for critically ill patients is 49%. The "cytokine storm" is considered as the main cause of pathogenesis for coronavirus disease-19 (COVID-19)-related respiratory failure, hemoperfusion may be a modality for treatment of disease. Read More

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The efficacy of intratracheal administration of surfactant and budesonide combination in the prevention of bronchopulmonary dysplasia.

J Res Med Sci 2021 27;26:31. Epub 2021 May 27.

Department of Pediatrics and Neonatology, Alzahra Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Bronchopulmonary dysplasia (BPD) remains a major problem in preterm infants that occurs in up to 50% of preterm infants. The inflammation plays an important role in its pathogenesis. This study was conducted to evaluate the efficacy intratracheal budesonide administration in combination with surfactant in the prevention of BPD in preterm infants. Read More

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Intensive Care Management of Severe Tetanus.

Indian J Crit Care Med 2021 May;25(Suppl 2):S155-S160

Department of Medicine, Seth GS Medical College and KEM Hospital, Parel, Mumbai, Maharashtra, India.

Tetanus is caused by an exotoxin, tetanospasmin, produced by , an anaerobic gram-positive bacillus.Tetanospasmin prevents the release of inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in the spinal cord, brainstem motor nuclei, and the brain, producing muscle rigidity and tonic spasms.Trismus (lockjaw), dysphagia, laryngeal spasms, rigidity of limbs and paraspinal muscles, and opisthotonic posture are common. Read More

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[Posterior reversible encephalopathy síndrome in critical COVID-19 patients: report of two cases.]

Rev Esp Anestesiol Reanim 2021 Jul 30. Epub 2021 Jul 30.

Servicio de Anestesiología, Reanimación y Terapéutica del Dolor; Hospital General Universitario de Albacete, Albacete, España.

Posterior reversible encephalopathy syndrome (PRES) is an acute neurological disorder characterized by variable symptoms and radiological images characteristic of vasogenic parietal-occipital edema. It is associated with clinical conditions such as high blood pressure, infection / sepsis, or cytotoxic / immunosuppressive drugs, among others. It is characterized pathophysiologically by endothelial damage with breakdown of blood-brain barrier (BBB), cerebral hypoperfusion, and vasogenic edema. Read More

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Driving Pressure is a Risk Factor for ARDS in Mechanically Ventilated Subjects Without ARDS.

Respir Care 2021 Aug 3. Epub 2021 Aug 3.

Ciber Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.

Background: Driving pressure (ΔP) has been described as a risk factor for mortality in patients with ARDS. However, the role of ΔP in the outcome of patients without ARDS and on mechanical ventilation has received less attention. Our objective was to evaluate the association between ΔP on the first day of mechanical ventilation with the development of ARDS. Read More

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Thrombomodulin is associated with increased mortality and organ failure in mechanically ventilated children with acute respiratory failure: biomarker analysis from a multicenter randomized controlled trial.

Crit Care 2021 Aug 3;25(1):271. Epub 2021 Aug 3.

Division of Pediatric Critical Care, Department of Pediatrics, University of California, Los Angeles, Los Angeles, CA, USA.

Background: Acute respiratory failure (ARF) can progress to acute respiratory distress syndrome and death. Biomarkers may allow for risk stratification and prognostic enrichment in ARF. Thrombomodulin (TM) is a transmembrane antithrombotic mediator expressed in endothelial cells. Read More

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Respiratory Distress in Hospitalized Non-Mechanically Ventilated COVID-19 Adults: A Retrospective Multicenter Cohort Study.

Am J Hosp Palliat Care 2021 Aug 4:10499091211036702. Epub 2021 Aug 4.

Division of Geriatrics and Palliative Medicine, Department of Medicine, Northwell Health, Manhasset, NY, USA.

Background: COVID-19 typically presents with respiratory symptoms which may progress with severe disease. There are standard guidelines for managing respiratory distress (e.g. Read More

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The Efficacy of Hydroxychloroquine and Azithromycin Combination Therapy on Hospital Mortality in COVID 19 Pneumonia Patients.

Turk J Med Sci 2021 Aug 4. Epub 2021 Aug 4.

Background/aim: Effective therapeutic approaches for SARS-CoV-2 pandemic are urgently needed. Hydroxychloroquine (HCQ) alone or in combination with azithromycin has been used in several countries, without any clear evidence. This study aimed to determine the effectiveness and safety of hydroxychloroquine as compared to hydroxychloroquine and azithromycin combination in patients with COVID-19 pneumonia. Read More

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Clinical efficacy and safety of Janus kinase inhibitors for COVID-19: A systematic review and meta-analysis of randomized controlled trials.

Int Immunopharmacol 2021 Jul 31;99:108027. Epub 2021 Jul 31.

Department of Internal Medicine, Kaohsiung Veterans General Hospital, Tainan Branch, Tainan, Taiwan. Electronic address:

Objectives: This systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to investigate the clinical efficacy and safety of Janus kinase (JAK) inhibitors for COVID-19 patients.

Methods: PubMed, Embase, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov were searched from inception to July 12, 2021. Read More

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Association of Coronavirus Disease-19 Hospitalization Volume and Case Growth at United States Hospitals with Patient Outcomes.

Am J Med 2021 Jul 31. Epub 2021 Jul 31.

Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT; Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, CT.

Background: Whether the volume of coronavirus disease-19 (COVID-19) hospitalizations is associated with outcomes has important implications for the organization of hospital care both during this pandemic and also future novel and rapidly evolving high-volume conditions.

Methods: We identified COVID-19 hospitalizations at US hospitals in the American Heart Association COVID-19 Cardiovascular Disease Registry with ≥10 cases between January and August 2020. We evaluated the association of (1) COVID-19 hospitalization volume and 2) weekly case growth indexed to hospital bed capacity, with hospital risk-standardized in-hospital case-fatality rate (rsCFR). Read More

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Higher severity and risk of in-hospital mortality for COVID-19 patients with cancer during the year 2020 in Brazil: A countrywide analysis of secondary data.

Cancer 2021 Aug 3. Epub 2021 Aug 3.

Clinical Epidemiology Program, Brazilian National Cancer Institute (INCA), Rio de Janeiro, Brazil.

Background: Coronavirus disease 2019 (COVID-19) and cancer are serious public health problems worldwide. However, little is known about the risk factors of in-hospital mortality among COVID-19 patients with and without cancer in Brazil. The objective of this study was to evaluate the risk factors of in-hospital mortality among COVID-19 patients with and without cancer and to compare mortality according to gender and topography during the year 2020 in Brazil. Read More

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Effect of a Sedation and Ventilator Liberation Protocol vs Usual Care on Duration of Invasive Mechanical Ventilation in Pediatric Intensive Care Units: A Randomized Clinical Trial.

JAMA 2021 08;326(5):401-410

Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, Ireland.

Importance: There is limited evidence on the optimal strategy for liberating infants and children from invasive mechanical ventilation in the pediatric intensive care unit.

Objective: To determine if a sedation and ventilator liberation protocol intervention reduces the duration of invasive mechanical ventilation in infants and children anticipated to require prolonged mechanical ventilation.

Design, Setting, And Participants: A pragmatic multicenter, stepped-wedge, cluster randomized clinical trial was conducted that included 17 hospital sites (18 pediatric intensive care units) in the UK sequentially randomized from usual care to the protocol intervention. Read More

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Children with SARS-CoV-2 in the National COVID Cohort Collaborative (N3C).

medRxiv 2021 Jul 23. Epub 2021 Jul 23.

Importance: SARS-CoV-2.

Objective: To determine the characteristics, changes over time, outcomes, and severity risk factors of SARS-CoV-2 affected children within the National COVID Cohort Collaborative (N3C).

Design: Prospective cohort study of patient encounters with end dates before May 27th, 2021. Read More

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Microbial etiologies of ventilator-associated pneumonia (VAP) in intensive care unit of Beni-Suef University's Hospital.

Beni Suef Univ J Basic Appl Sci 2021 29;10(1):41. Epub 2021 Jul 29.

Department of Microbiology and Immunology, Faculty of Pharmacy, Beni-Suef University, Beni Suef, Egypt.

Background: Ventilator-associated pneumonia (VAP) is a major health problem for people intubated in intensive care units (ICUs), leading to increased mortality rates, hospital stay, and treatment costs. In the present study, the core pathogens causing VAP in Beni-Suef University's Hospital, Egypt, was investigated over a study period of 2 years (2017-2019).

Results: Of a total of 213 patients subjected to mechanical ventilation, 60 have developed VAP during their stay in the ICU. Read More

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Extracorporeal membrane oxygenation for tuberculosis pneumonia with empyema.

Respir Med Case Rep 2021 27;34:101481. Epub 2021 Jul 27.

Department of Cardiovascular Surgery, Division of Surgery, Pontificia Universidad Católica, Santiago, Chile.

Acute respiratory distress syndrome (ARDS) caused by (TB) is a rare entity. Extracorporeal membrane oxygenation (ECMO) therapy had been used as an effective therapy for this cases, but the evidence is scarce. We present a case that took place in the middle of SARS-CoV2 pandemic. Read More

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