47,453 results match your criteria Ventilation Mechanical


Pediatric patients with COVID-19 admitted to intensive care units in Brazil: a prospective multicenter study.

J Pediatr (Rio J) 2020 Aug 4. Epub 2020 Aug 4.

Brazilian Research Network in Pediatric Intensive Care (BRnet-PIC), Brazil.

Objective: To describe the clinical characteristics of children and adolescents admitted to intensive care with confirmed COVID-19.

Method: Prospective, multicenter, observational study, in 19 pediatric intensive care units. Patients aged 1 month to 19 years admitted consecutively (March-May 2020) were included. Read More

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http://dx.doi.org/10.1016/j.jped.2020.07.002DOI Listing

Predictors for long-term mortality in COPD patients requiring non-invasive positive pressure ventilation for the treatment of acute respiratory failure.

Clin Respir J 2020 Aug 11. Epub 2020 Aug 11.

Department of Respiratory Medicine, Maastricht University Medical Center, Maastricht, The Netherlands.

Introduction: The effectiveness of non-invasive mechanical ventilation (NIV) in the management of COPD patients suffering from acute respiratory failure (ARF) as a consequence of exacerbation of the disease, is well-established. However, data on long-term outcomes and their predictors, including the individual response to NIV, are scarce.

Objectives: To investigate predictors for short- and long-term mortality in this study population. Read More

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http://dx.doi.org/10.1111/crj.13251DOI Listing

Effects of intraoperative dexmedetomidine on the incidence of acute kidney injuryin pediatric cardiac surgery patients: A randomized controlled trial.

Paediatr Anaesth 2020 Aug 11. Epub 2020 Aug 11.

Department of Anesthesiology and Pain medicine, Seoul National University Hospital, Seoul National University College of Medicine, #101 Daehak-ro, Jongno-GU, Seoul, 03080, Republic of Korea.

Background: Perioperative dexmedetomidineuse has been reported to reduce the incidence of postoperative acute kidney injuryafter adult cardiac surgery. However, large-scale randomized controlled trials evaluating the effect of dexmedetomidine use on acute kidney injury in pediatric patients are lacking.

Aims: We investigated whether intraoperativedexmedetomidine could reduce the incidence of acute kidney injury in pediatric cardiac surgery patients. Read More

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http://dx.doi.org/10.1111/pan.13995DOI Listing

Does Bilevel Noninvasive Ventilation Have a Bronchodilating Effect and Alter Respiratory Mechanics in Asthmatic Individuals After Bronchoprovocation? Randomized, Crossover Study.

J Aerosol Med Pulm Drug Deliv 2020 Aug 11. Epub 2020 Aug 11.

Rehabilitation Sciences Program, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil.

Noninvasive ventilation (NIV) has an additional important effect that does not occur with medicinal therapy: a reduction in the work of breathing. Understanding the mechanical effects of these therapies is of considerable importance and can affect clinical decision making. Evaluate the effects of NIV compared to albuterol on lung function and respiratory mechanics in asthmatic adolescents and young adults after bronchoprovocation and determine the effects of a hypertonic saline solution on lung function respiratory mechanics. Read More

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http://dx.doi.org/10.1089/jamp.2020.1608DOI Listing

Delirium, Cerebral Perfusion and High Frequency Vital Sign Monitoring in the Critically Ill: The CONFOCAL-2 Feasibility Study.

Ann Am Thorac Soc 2020 Aug 11. Epub 2020 Aug 11.

Queen's University, 4257, Centre for Neuroscience Studies, Kingston, Ontario, Canada.

Rationale: Studies suggest that reduced cerebral perfusion may contribute to delirium development in the intensive care unit (ICU). However, evidence is limited due to factors including small sample size and limited inclusion of covariates.

Objectives: To assess the feasibility of a multicentre prospective observational study using a multi-modal data collection platform. Read More

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http://dx.doi.org/10.1513/AnnalsATS.202002-093OCDOI Listing

Discharge Practices for Children with Home Mechanical Ventilation Across the United States: Key Informant Perspectives.

Ann Am Thorac Soc 2020 Aug 11. Epub 2020 Aug 11.

Northwestern University Feinberg School of Medicine, 12244, Division of Pediatric Critical Care Medicine, Chicago, Illinois, United States.

Rationale: In 2016 the ATS released Clinical Practice Guidelines for Pediatric Chronic Home Invasive Ventilation pertaining to discharge practices and subsequent management for patients with invasive ventilation using a tracheostomy. It is not known to what extent current US practices adhere to these recommendations.

Objective: Hospital discharge practices and home health services are not standardized for children with invasive home mechanical ventilation (HMV). Read More

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http://dx.doi.org/10.1513/AnnalsATS.201912-875OCDOI Listing

Surfactant lavage for neonatal meconium aspiration syndrome-An updated meta-analysis.

J Chin Med Assoc 2020 Aug;83(8):761-773

aDepartment of Neonates, Children's Hospital of Nanjing Medical University, Nanjing, China bDepartment of Neonates, Jiangsu Maternal and Child Health Hospital, Nanjing, China.

Background: Surfactant lavage seems to have a good application prospect both in experimental models and patients with meconium aspiration syndrome (MAS). Data regarding the effect of surfactant lavage on pulmonary complications of MAS are conflicting. In view of these uncertainties, an updated meta-analysis including the latest literatures is performed. Read More

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http://dx.doi.org/10.1097/JCMA.0000000000000357DOI Listing

Influence of early extubation on post-operative outcomes after pediatric lung transplantation.

Pediatr Transplant 2020 Aug 11:e13776. Epub 2020 Aug 11.

Department of Pediatrics, Pediatric Critical Care Division, University of Texas - Health Science Centre At Houston, Childern's Memorial Herman Hospital, Houston, TX, USA.

Lung transplantation has become an accepted therapeutic option for a select group of children with end-stage lung disease. We evaluated the impact of early extubation in a pediatric lung transplant population and its post-operative outcomes. Single-center retrospective study. Read More

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http://dx.doi.org/10.1111/petr.13776DOI Listing

Seizure activity following atracurium continuous rate infusion in three mechanically ventilated juvenile dogs.

J Vet Emerg Crit Care (San Antonio) 2020 Aug 11. Epub 2020 Aug 11.

Department of Clinical Science and Services, The Royal Veterinary College, North Mymms, Hertfordshire, UK.

Objective: To describe patient recovery in dogs that had undergone mechanical ventilation (MV) and received atracurium as a continuous rate infusion (CRI).

Case Series Summary: Three dogs were treated with atracurium CRI while mechanically ventilated and were successfully weaned. All were pediatric patients (2-3 months old) ventilated due to respiratory fatigue and hypoxemia. Read More

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http://dx.doi.org/10.1111/vec.12989DOI Listing

A simple method of mechanical power calculation: using mean airway pressure to replace plateau pressure.

J Clin Monit Comput 2020 Aug 11. Epub 2020 Aug 11.

Department of Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, 1 Shuaifuyuan, Dongcheng District, Beijing, China.

The reference method for mechanical power (MP) calculation proposed by Gattinoni et al. is based on plateau pressure (P) which needs an inspiratory hold. This study aims to introduce and validate a simple surrogate for MP calculation without any intervention in ventilated patients with or without acute respiratory distress syndrome (ARDS). Read More

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http://dx.doi.org/10.1007/s10877-020-00575-yDOI Listing

Proportional modes of ventilation: technology to assist physiology.

Intensive Care Med 2020 Aug 11. Epub 2020 Aug 11.

Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, 209 Victoria Street, Room 4-08, Toronto, ON, M5B 1T8, Canada.

Proportional modes of ventilation assist the patient by adapting to his/her effort, which contrasts with all other modes. The two proportional modes are referred to as neurally adjusted ventilatory assist (NAVA) and proportional assist ventilation with load-adjustable gain factors (PAV+): they deliver inspiratory assist in proportion to the patient's effort, and hence directly respond to changes in ventilatory needs. Due to their working principles, NAVA and PAV+ have the ability to provide self-adjusted lung and diaphragm-protective ventilation. Read More

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http://dx.doi.org/10.1007/s00134-020-06206-zDOI Listing

Low-dose hydrocortisone in patients with COVID-19 and severe hypoxia (COVID STEROID) trial-Protocol and statistical analysis plan.

Acta Anaesthesiol Scand 2020 Jul 21. Epub 2020 Jul 21.

Department of Intensive Care, Copenhagen University Hospital, Copenhagen, Denmark.

Introduction: Severe acute respiratory syndrome coronavirus-2 has caused a pandemic of coronavirus disease (COVID-19) with many patients developing hypoxic respiratory failure. Corticosteroids reduce the time on mechanical ventilation, length of stay in the intensive care unit and potentially also mortality in similar patient populations. However, corticosteroids have undesirable effects, including longer time to viral clearance. Read More

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http://dx.doi.org/10.1111/aas.13673DOI Listing

[Severe sensory-motor axonal neuropathy following diabetic ketoacidosis].

Rinsho Shinkeigaku 2020 Aug 8. Epub 2020 Aug 8.

Department of Neurology, Teikyo University School of Medicine.

We report a case of severe sensory-motor axonal neuropathy on the lower extremities associated with diabetic ketoacidosis (DKA). A sixteen-year-old boy developed coma and admitted to our hospital. We diagnosed him with DKA based on remarkable hyperglycemia, severe acidosis with hyperketonemia. Read More

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http://dx.doi.org/10.5692/clinicalneurol.cn-001433DOI Listing

Intratracheal administration of budesonide with surfactant in very low birth weight infants to prevent bronchopulmonary dysplasia.

Turk J Pediatr 2020 ;62(4):551-559

Department of Pediatrics, Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.

Background And Objectives: Respiratory distress syndrome (RDS) is a major cause of early postnatal death in preterm infants. Bronchopulmonary dysplasia (BPD) is one of the most fatal chronic respiratory complications of preterm infants after management of RDS. Anti-inflammatory therapy with corticosteroid is one of the effective treatments to prevent BPD. Read More

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http://dx.doi.org/10.24953/turkjped.2020.04.004DOI Listing
January 2020

Indoor Emissions of Total and Fluorescent Supermicron Particles during HOMEChem.

Indoor Air 2020 Aug 10. Epub 2020 Aug 10.

Department of Environmental Science, Policy, and Management, University of California, Berkeley, CA, USA.

Inhalation of particulate matter is associated with adverse health outcomes. The fluorescent portion of supermicron particulate matter has been used as a proxy for bioaerosols.The sources and emission rates of fluorescent particles in residential environments are not wellunderstood. Read More

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http://dx.doi.org/10.1111/ina.12731DOI Listing

Maternal morbidity and mortality due to placenta accreta spectrum disorders.

Best Pract Res Clin Obstet Gynaecol 2020 Jul 20. Epub 2020 Jul 20.

Department of Obstetrics, Santa Maria University Hospital, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal; Medical School, University of Lisbon, Av. Prof. Egas Moniz, 1649-028 Lisbon, Portugal.

Placenta accreta spectrum (PAS) disorders are an increasing health problem in many parts of the world. They are an important risk factor for adverse maternal outcomes related to delivery, with a reported 18-fold increase in maternal morbidity. Profuse haemorrhage after attempting to remove the placenta is the most frequent complication and can lead to major maternal morbidity and ultimately to maternal death. Read More

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http://dx.doi.org/10.1016/j.bpobgyn.2020.07.011DOI Listing

Limited prognostic accuracy of the CRB-65 and qSOFA in patients presenting with pneumonia and immunosuppression.

Eur J Intern Med 2020 Aug 7. Epub 2020 Aug 7.

Division of Pulmonology, Medical Department I, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. Electronic address:

Background: Scores for risk prediction used in immunocompetent patients with sepsis or pneumonia are poorly evaluated in immunocompromised patients. Therefore, we evaluated the prognostic value of the qSOFA- and CRB-65-criteria in immunocompromised patients presenting with pneumonia.

Methods: Retrospective cohort study including consecutive patients hospitalized with pneumonia and immunosuppression without treatment restrictions. Read More

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http://dx.doi.org/10.1016/j.ejim.2020.08.006DOI Listing

Clinical characteristics and outcomes of patients with adult congenital heart disease listed for heart and heart‒lung transplantation in the Eurotransplant region.

J Heart Lung Transplant 2020 Jul 25. Epub 2020 Jul 25.

Department of Cardiology, University Heart and Vascular Center Hamburg, Hamburg, Germany; Partner Site Hamburg/Kiel/Lübeck, German Center of Cardiovascular Research (DZHK), Berlin, Germany.

Background: The therapeutic success in patients with congenital heart disease (CHD) leads to a growing number of adults with CHD (adult CHD [ACHD]) who develop end-stage heart failure. We aimed to determine patient characteristics and outcomes of ACHD listed for heart transplantation.

Methods: Using data from all the patients with ACHD in 20 transplant centers in the Eurotransplant region from 1999 to 2015, we analyzed patient characteristics, waiting list, and post-transplantation outcomes. Read More

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http://dx.doi.org/10.1016/j.healun.2020.07.012DOI Listing

Effect of dexmedetomidine on inflammation in patients with sepsis requiring mechanical ventilation: a sub-analysis of a multicenter randomized clinical trial.

Crit Care 2020 08 10;24(1):493. Epub 2020 Aug 10.

Department of Clinical Epidemiology, Hyogo College of Medicine, Nishinomiya, Japan.

Background: Administration of dexmedetomidine has been reported to improve inflammatory response in animals. We explored the effects of administering dexmedetomidine on the levels of C-reactive protein (CRP) and procalcitonin, and thus on inflammation, in patients with sepsis enrolled in a randomized clinical trial.

Methods: The DESIRE trial was a multicenter randomized clinical trial in which adult patients with sepsis were sedated with (DEX group) or without (non-DEX group) dexmedetomidine while on mechanical ventilators. Read More

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http://dx.doi.org/10.1186/s13054-020-03207-8DOI Listing

A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection.

Crit Care 2020 08 10;24(1):494. Epub 2020 Aug 10.

Unidad de Paciente Crítico Pediátrico, Hospital El Carmen de Maipú, Santiago, Chile.

Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing. Read More

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http://dx.doi.org/10.1186/s13054-020-03197-7DOI Listing

Individualized positive end-expiratory pressure setting in patients with severe acute respiratory distress syndrome supported with veno-venous extracorporeal membrane oxygenation.

Perfusion 2020 Aug 10:267659120946728. Epub 2020 Aug 10.

Department of Critical Care Medicine, The Third Central Clinical College of Tianjin Medical University, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Artificial Cell Engineering Technology Research Center, Tianjin Institute of Hepatobiliary Disease, Tianjin, China.

Background: Patients with acute respiratory distress syndrome supported with veno-venous extracorporeal membrane oxygenation benefit from higher positive end-expiratory pressure combined with conventional ventilation during the early extracorporeal membrane oxygenation period. The role of incremental positive end-expiratory pressure titration in patients with severe acute respiratory distress syndrome supported with veno-venous extracorporeal membrane oxygenation remains unclear. This study aimed to determine the preferred method for setting positive end-expiratory pressure in patients with severe acute respiratory distress syndrome on veno-venous extracorporeal membrane oxygenation support. Read More

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http://dx.doi.org/10.1177/0267659120946728DOI Listing

An assessment of baseline risk factors for peripartum maternal critical care interventions.

J Matern Fetal Neonatal Med 2020 Aug 10:1-6. Epub 2020 Aug 10.

Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, USA.

Background: Maternal morbidity presents a growing challenge to the American healthcare system and increasing numbers of patients are requiring higher levels of care in pregnancy. Identifying patients at high risk for critical care interventions, including intensive care unit admission, during delivery hospitalizations may facilitate appropriate multidisciplinary planning and lead to improved maternal safety. Baseline risk factors for critical care in pregnancy have not been well-described previously. Read More

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http://dx.doi.org/10.1080/14767058.2020.1803258DOI Listing

Reversible platypnea-orthodeoxia in COVID-19 acute respiratory distress syndrome survivors.

Respir Physiol Neurobiol 2020 Aug 7:103515. Epub 2020 Aug 7.

Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433, Singapore. Electronic address:

Platypnea-orthodeoxia syndrome (POS) is a rare clinical syndrome characterized by orthostatic oxygen desaturation and positional dyspnea from supine to an upright position. We observed POS in 5 of 20 cases of severe 2019 novel coronavirus (COVID-19) pneumonia, which demonstrated persistently elevated shunt fraction even after liberation from mechanical ventilation. POS was first observed during physiotherapy sessions; median oxygen desaturation was 8% (range: 8-12%). Read More

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http://dx.doi.org/10.1016/j.resp.2020.103515DOI Listing

Effects of Hydroxychloroquine on Covid-19 in Intensive Care Unit Patients: Preliminary Results.

Int J Antimicrob Agents 2020 Aug 7:106136. Epub 2020 Aug 7.

Aix-Marseille University, Assistance Publique Hôpitaux de Marseille, Department of Anesthesiology and Intensive Care, Hôpital Nord, Marseille, 13015, France.

During the Covid-19 pandemic, a large number of intensive care unit (ICU) patients received hydroxychloroquine. The primary objective of our study was to assess the effects of hydroxychloroquine according to its plasma concentration in ICU patients. To this purpose, a single-center retrospective study was performed from March to April 2020 in an ICU of a university hospital. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2020.106136DOI Listing

The Outcome of COVID-19 in Patients with Hematological Malignancy.

J Med Virol 2020 Aug 10. Epub 2020 Aug 10.

Republic of Turkey, Deputy Minister of Health, Ankara, Turkey.

Introduction: In this study, we aim to report the outcome of COVID-19 in patients with hematological malignancy in Turkey.

Method: The data of laboratory-confirmed 188,897 COVID-19 patients diagnosed between March 11, 2020 and June 22, 2020 included in the Republic of Turkey, Ministry of Health database were analyzed retrospectively. All of the COVID-19 patients with hematological malignancy (n=740) were included in the study and an age, gender and comorbidity matched COVID-19 patients without cancer (n=740) at 1:1 ratio was used for comparison. Read More

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http://dx.doi.org/10.1002/jmv.26404DOI Listing

A multicenter study on epidemiological and clinical characteristics of 125 newborns born to women infected with COVID-19 by Turkish Neonatal Society.

Eur J Pediatr 2020 Aug 10. Epub 2020 Aug 10.

Department of Pediatrics, Division of Neonatology, School of Medicine, Gazi University, Ankara, Turkey.

Limited data are available on pregnant women with COVID-19 and their neonates. We aimed to evaluate the epidemiological and clinical characteristics of newborns born to women infected with COVID-19. A multicenter cohort study was conducted among newborns born to mothers with COVID-19 in 34 neonatal intensive care units (NICUs) in Turkey. Read More

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http://dx.doi.org/10.1007/s00431-020-03767-5DOI Listing

[Weaning in neurological and neurosurgical early rehabilitation-Results from the "WennFrüh" study of the German Society for Neurorehabilitation].

Nervenarzt 2020 Aug 10. Epub 2020 Aug 10.

Institut für Neurorehabilitation und Evidenzbasierung, An-Institut der Universität Greifswald, BDH-Klinik Greifswald gGmbH, Karl-Liebknecht-Ring 26a, 17491, Greifswald, Deutschland.

Neurological and neurosurgical early rehabilitation patients are often so critically ill that they must be weaned from mechanical ventilation in addition to early rehabilitative treatment. The German Society for Neurorehabilitation (DGNR) carried out a survey and asked neurological weaning units to provide information on structural characteristics of the facility, including personnel and technical resources and the number of cases and outcome based on anonymous data. In total 36 weaning units from 11 federal states with a total of 496 beds participated in the survey. Read More

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http://dx.doi.org/10.1007/s00115-020-00976-zDOI Listing

Recurrent massive pulmonary emboli in a critically ill patient with COVID-19.

Anaesth Rep 2020 Jul-Dec;8(2):e12059. Epub 2020 Aug 1.

Adult Intensive Care Unit Oxford University Hospitals NHS Foundation Trust Oxford UK.

We report the haematological management of a critically ill patient with coronavirus disease 2019 (COVID-19), with recurrent massive pulmonary emboli. A previous healthy 56-year-old man presented to the emergency department with severe hypoxaemic respiratory failure due to suspected COVID-19. He required invasive mechanical ventilation and transfer to the intensive care unit for increasing ventilatory requirements and cardiovascular instability. Read More

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http://dx.doi.org/10.1002/anr3.12059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395430PMC

COVID-19 Infection in Kidney Transplant Recipients: A Single-Center Case Series of 22 Cases From Belgium.

Kidney Med 2020 Jul-Aug;2(4):459-466. Epub 2020 Jun 15.

Division of Nephrology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.

Rationale & Objective: The world is facing a global pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although kidney transplant recipients are at increased risk for viral infections, the impact of their chronic immunosuppressed status on the risk for acquiring coronavirus disease 2019 (COVID-19) and disease severity is unknown.

Study Design: All cases of COVID-19 infection in our cohort of kidney transplant recipients were prospectively monitored. Read More

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http://dx.doi.org/10.1016/j.xkme.2020.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295531PMC

Nutritional survey in critically ill children: a single center study in China.

Transl Pediatr 2020 Jun;9(3):221-230

Department of Pediatric Intensive Care Unit, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: The incidence of malnutrition in children, who were admitted to the pediatric intensive care unit (PICU), has kept high level over the past 30 years. In addition, nutrition status of critically ill children deteriorates further during the changing of their conditions and may have a negative effect on patients' outcomes. This study aimed to determine the nutritional status of critically ill children and to survey current nutrition practices and support in PICU. Read More

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http://dx.doi.org/10.21037/tp-19-173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347761PMC

Awake Proning: A Necessary Evil During the COVID-19 Pandemic.

Cureus 2020 Jul 3;12(7):e8989. Epub 2020 Jul 3.

Dentistry, Karachi Medical and Dental College, Karachi, PAK.

The spread of COVID-19 has been exponential throughout the globe. Though only a small percentage of infected individuals reach the critical stage of the disease, i.e. Read More

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http://dx.doi.org/10.7759/cureus.8989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402434PMC

Morphine in the Setting of Acute Heart Failure: Do the Risks Outweigh the Benefits?

Card Fail Rev 2020 Mar 28;6:e20. Epub 2020 Jul 28.

Departments of Cardiology, Rambam Medical Centre and B Rappaport Faculty of Medicine, Technion Medical School Haifa, Israel.

The use of opioids in acute pulmonary oedema is considered standard therapy by many physicians. The immediate relieving effect of morphine on the key symptomatic discomfort associated with acute heart failure, dyspnoea, facilitated the categorisation of morphine as a beneficial treatment in this setting. During the last decade, several retrospective studies raised concerns regarding the safety and efficacy of morphine in the setting of acute heart failure. Read More

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http://dx.doi.org/10.15420/cfr.2019.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407569PMC

[Influence of co-morbidities on the progression and prognosis of patients with chronic obstructive pulmonary disease in a Tunisian Hospital].

Pan Afr Med J 2020 9;36:76. Epub 2020 Jun 9.

Service de Pneumologie et d'Allergologie, Hôpital Universitaire Fattouma Bourguiba, Rue 1er juin, Monastir, Tunisie.

Introduction: chronic obstructive pulmonary disease (COPD) has been frequently associated with co-morbidities. The purpose of our study is to analyze the impact of co-morbidities on the progression and prognosis of COPD.

Methods: we conducted a retrospective study of patients with COPD hospitalized and/or followed up in the Department of Pneumology at the Fattouma Bourguiba University Hospital in Monastir over the period January 2000-December 2017. Read More

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http://dx.doi.org/10.11604/pamj.2020.36.76.21511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7386274PMC

Weather the Cytokine Storm: A Report of Successful Management of a Colon Cancer Survivor and a Critically Ill Patient with COVID-19.

Case Rep Oncol 2020 May-Aug;13(2):754-759. Epub 2020 Jun 29.

Division of Hematology/Oncology, Augusta University, Augusta, Georgia, USA.

Patients with novel corona virus infection (COVID-19) can develop acute respiratory failure secondary to acute respiratory distress syndrome. Cytokine storm is suggested as one of underlying mechanisms for the rapid clinical decline. Immunocompromised patients and cancer patients are at particular risk for poor outcomes due to COVID-19 infection. Read More

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http://dx.doi.org/10.1159/000509507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7360508PMC

Durvalumab-Induced Diffuse Alveolar Hemorrhage: An Autopsy Case Report.

Case Rep Oncol 2020 May-Aug;13(2):696-701. Epub 2020 Jun 22.

Department of Respiratory Medicine, Osaka Police Hospital, Osaka, Japan.

Durvalumab, a programmed cell death ligand 1 inhibitor, induces various immune-related adverse events (irAEs), including lung injury. However, diffuse alveolar hemorrhage (DAH) is a rare type of lung injury due to immune checkpoint inhibitors. A 76-year-old man with c-stage IIIA squamous cell carcinoma of the lung received maintenance durvalumab therapy after chemoradiotherapy. Read More

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http://dx.doi.org/10.1159/000507848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383190PMC

A comprehensive review of COVID-19 characteristics.

Biol Proced Online 2020 4;22:19. Epub 2020 Aug 4.

Department of biology, Ashkezar branch, Islamic Azad University of Yazd, Ashkezar, Yazd Iran.

In December 2019, a novel coronavirus, named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) or (2019-nCoV) with unknown origin spread in Hubei province of China. The epidemic disease caused by SARS-CoV-2 called coronavirus disease-19 (COVID-19). The presence of COVID-19 was manifested by several symptoms, ranging from asymptomatic/mild symptoms to severe illness and death. Read More

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http://dx.doi.org/10.1186/s12575-020-00128-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402395PMC

Overexpression of CXCL14 Alleviates Ventilator-Induced Lung Injury through the Downregulation of PKM2-Mediated Cytokine Production.

Mediators Inflamm 2020 23;2020:7650978. Epub 2020 Jul 23.

Department of Pediatrics, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan, Hubei 430071, China.

Ventilator-induced lung injury (VILI) is one of the most common complications of mechanical ventilation (MV), which strongly impacts the outcome of ventilated patients. Current evidences indicated that inflammation is a major contributor to the pathogenesis of VILI. Our results showed that MV induced excessive proinflammatory cytokine productions together with decreased CXCL14 and increased PKM2 expressions in injured lungs. Read More

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http://dx.doi.org/10.1155/2020/7650978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396076PMC

Effectiveness of simulation based teaching of ventilatory management among non-anaesthesiology residents to manage COVID 19 pandemic - A Quasi experimental cross sectional pilot study.

Indian J Anaesth 2020 May 23;64(Suppl 2):S136-S140. Epub 2020 May 23.

Department of Community Medicine, GSL Medical College, Rajahmundry, Andhra Pradesh, India.

Background And Aims: Simulation is one of the important learning tools when it comes to skill acquisition and as a supplemental tool for training in high stake situations like COVID-19. The aim of this study is to meet the global requirements of knowledge on ventilatory management, prepare and to evaluate the effectiveness of the teaching module for non-anesthesiology trainees on COVID-19 patients.

Methods: Quasi experimental cross sectional pilot study was conducted with a sample of twenty-six trainees. Read More

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http://dx.doi.org/10.4103/ija.IJA_452_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293371PMC

[Risk factors for mechanical ventilation in patients with severe multiple trauma].

Beijing Da Xue Xue Bao Yi Xue Ban 2020 Aug;52(4):738-742

Objective: To eludicate the risk factors of mechanical ventilation and prolonged mechanical ventilation in patients with severe multiple injuries.

Methods: Consecutive patients with severe multiple injures who were treated in Peking University People's Hospital Trauma Medical Center between December 2016 and December 2019 were enrolled in this restropective chart-review study. According to mechanical ventilation and ventilatory time, the patients were divided into mechanical ventilation (MV) group and non-mechanical ventilation (NMV) groups, prolonged mechanical ventilation (PMV) group and shortened mechanical ventilation (SMV) groups. Read More

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Positional Therapy and Regional Pulmonary Ventilation: High-resolution Alignment of Prone and Supine Computed Tomography Images in a Large Animal Model.

Anesthesiology 2020 Aug 4. Epub 2020 Aug 4.

From the Department of Radiology (Y.X., H.H., M.P., S.K., S.S., F.A., I.D., J.C.G., R.R.R.) the Department of Anesthesiology and Critical Care (M.C., K.T.M., M.C., N.A., A.K.), University of Pennsylvania, Philadelphia, Pennsylvania the Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia (N.J.T.).

Background: Prone ventilation redistributes lung inflation along the gravitational axis; however, localized, nongravitational effects of body position are less well characterized. The authors hypothesize that positional inflation improvements follow both gravitational and nongravitational distributions. This study is a nonoverlapping reanalysis of previously published large animal data. Read More

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http://dx.doi.org/10.1097/ALN.0000000000003509DOI Listing

Core outcomes sets for studies evaluating critical illness and patient recovery.

Curr Opin Crit Care 2020 Aug 6. Epub 2020 Aug 6.

Outcomes After Critical Illness and Surgery (OACIS) Group.

Purpose Of Review: Given the growing body of critical care clinical research publications, core outcome sets (COSs) are important to help mitigate heterogeneity in outcomes assessed and measurement instruments used, and have potential to reduce research waste. This article provides an update on COS projects in critical care medicine, and related resources and tools for COS developers.

Recent Findings: We identified 28 unique COS projects, of which 15 have published results as of May 2020. Read More

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http://dx.doi.org/10.1097/MCC.0000000000000750DOI Listing

Relationship between Platelet/Lymphocyte Ratio and Prognosis of Patients with Septic Acute Kidney Injury: A Pilot Study.

J Chin Med Assoc 2020 Jul 27. Epub 2020 Jul 27.

Department of Intensive Care Unit, Lanzhou University Second Hospital, Lanzhou, Gansu, China.

Background: To explore the potential role of the platelet/lymphocyte ratio as a prognostic marker in septic patients with acute kidney injury and to provide theoretical evidence for the epidemiological study of the prognosis of patients with septic acute kidney injury in its early stage.

Methods: A pilot study was conducted. A logistic regression analysis was conducted to screen the risk factors, and the selected factors were performed using multiple logistic regression analysis; a Receiver Operating Characteristic curve was used to determine the optimal cutoff value of the platelet/lymphocyte ratio and then to calculate the sensitivity and specificity of the platelet/lymphocyte ratio. Read More

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http://dx.doi.org/10.1097/JCMA.0000000000000404DOI Listing

Clinico-demographic profile & hospital outcomes of COVID-19 patients admitted at a tertiary care centre in north India.

Indian J Med Res 2020 Jul 22. Epub 2020 Jul 22.

Department of Hospital Administration, National Cancer Institute, All India Institute of Medical Sciences, Jhajjar, Haryana, India.

Background & Objectives: : In December 2019, a novel coronavirus (SARS-CoV-2) emerged in China and rapidly spread globally including India. The characteristic clinical observations and outcomes of this disease (COVID-19) have been reported from different countries. The present study was aimed to describe the clinico-demographic characteristics and in-hospital outcomes of a group of COVID-19 patients in north India. Read More

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http://dx.doi.org/10.4103/ijmr.IJMR_1788_20DOI Listing

[Evolution of Opinions on Chest Wall Stabilisation and Our Experience].

Acta Chir Orthop Traumatol Cech 2020 ;87(3):155-161

I. chirurgická klinika Fakultní nemocnice Olomouc a Lékařské fakulty Univerzity Palackého v Olomouci.

PURPOSE OF THE STUDY Rib fractures represent one of the most common fractures sustained by 10-40% of all patients with blunt chest trauma, their incidence increases with age. In the current literature, however, new indication criteria continue to emerge. The purpose of this study is to assess the indication criteria, the timing of surgery and the use of individual plates in dependence on fracture location in our patients after the chest wall stabilisation in a retrospective analysis. Read More

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January 2020

YKL-40 is a proposed biomarker of inflammation and remodelling elevated in children with bronchopulmonary dysplasia compared to asthma.

Acta Paediatr 2020 Aug 8. Epub 2020 Aug 8.

Astrid Lindgren Children's Hospital, Lung and Allergy Unit, Karolinska University Hospital, Stockholm, Sweden.

YKL-40 is a chitinase-like, secreted glycoprotein associated with several respiratory disorders, including asthma and oxidant-induced lung injuries. Its biological role remains unclear, but it correlates with markers of airway fibrosis and remodelling in asthma, where it has emerged as a candidate biomarker for non-type 2 inflammation. Bronchopulmonary dysplasia (BPD) is a chronic disorder, characterised by underdeveloped, damaged lungs following premature birth and mechanical ventilation, whereas asthma is a chronic inflammatory disease, often associated with atopy and reversibility in children (3). Read More

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http://dx.doi.org/10.1111/apa.15525DOI Listing

A Scoping Review of Registered Clinical Trials of Convalescent Plasma for COVID-19 and a Framework for Accelerated Synthesis of Trial Evidence (FAST Evidence).

Transfus Med Rev 2020 Jul 15. Epub 2020 Jul 15.

Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Clinical Epidemiology and Regenerative Medicine Programs, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; Department of Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada. Electronic address:

Many parallel studies of convalescent plasma with modest enrolment projections have been launched for the treatment of COVID-19. By pooling data from multiple parallel studies that are similar, we can increase the effective sample size and achieve enough statistical power to determine effectiveness more quickly through meta-analysis. A scoping review of registered clinical trials of convalescent plasma for COVID-19 was conducted to assess the feasibility of performing a rapid and timely meta-analysis that will support accelerated review for approval and implementation. Read More

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http://dx.doi.org/10.1016/j.tmrv.2020.06.005DOI Listing

Co-expression of NMDA-receptor subunits NR1, NR2A, and NR2B in dysplastic neurons of teratomas in patients with paraneoplastic NMDA-receptor-encephalitis: a retrospective clinico-pathology study of 159 patients.

Acta Neuropathol Commun 2020 Aug 8;8(1):130. Epub 2020 Aug 8.

Department of Neurology, West China Hospital, Sichuan University, 37th Guoxuexiang Road, Chengdu, Sichuan Province, China.

Objective: To comprehensively describe the pathological features of neurons in patients with ovarian teratomas and paraneoplastic anti-NMDAR encephalitis (anti-NMDARE), emphasizing on NMDA-receptor expression and infiltrating lymphocytes.

Methods: A retrospective study was performed in a large series of 159 patients from the West China Hospital. We retrospectively identified 12 patients with paraneoplastic anti-NMDARE (11 case with ovarian teratomas and 1 case with mixed germ cell tumor), which were compared to 35 patients with teratomas and no encephalitis and to 147 patients with anti-NMDARE and no evidence for tumors. Read More

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http://dx.doi.org/10.1186/s40478-020-00999-2DOI Listing

Delirium and encephalopathy in severe COVID-19: a cohort analysis of ICU patients.

Crit Care 2020 08 8;24(1):491. Epub 2020 Aug 8.

Hôpitaux Universitaires de Strasbourg, Service de Médecine Intensive-Réanimation, Nouvel Hôpital Civil, 1, place de l'Hôpital, F-67091, Strasbourg, Cedex, France.

Background: Neurotropism of SARS-CoV-2 and its neurological manifestations have now been confirmed. We aimed at describing delirium and neurological symptoms of COVID-19 in ICU patients.

Methods: We conducted a bicentric cohort study in two French ICUs of Strasbourg University Hospital. Read More

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http://dx.doi.org/10.1186/s13054-020-03200-1DOI Listing

Transcatheter mitral valve repair in patients with chronic liver disease: Insights from the national inpatient sample.

Catheter Cardiovasc Interv 2020 Aug 8. Epub 2020 Aug 8.

Guthrie Clinic/Robert Packer Hospital, Sayre, Pennsylvania, USA.

Objective: To evaluate contemporary national trends of morbidity, mortality, and healthcare utilization in patients with mitral regurgitation (MR) and co-existing chronic liver disease (CLD) undergoing transcatheter mitral valve repair (TMVR).

Methods: The National Inpatient Sample (NIS) was used to assess trends in patients undergoing TMVR between January 2012 and December 2017. Propensity match analysis was done to compare it to subjects without underlying CLD. Read More

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http://dx.doi.org/10.1002/ccd.29173DOI Listing

Pre-existing cerebrovascular disease and poor outcomes of COVID-19 hospitalized patients: a meta-analysis.

J Neurol 2020 Aug 8. Epub 2020 Aug 8.

Department of Neurology, Creighton University School of Medicine, Omaha, NE, USA.

Background: Due to pro-inflammatory and hypercoagulation states, COVID-19 infection is believed to increase the risk of stroke and worsen the outcomes of the patients having pre-existing cerebrovascular diseases (CeVD). There is limited literature on prevalence of pre-existing CeVD in COVID-19 patients, and outcomes are unknown. The objective of this meta-analysis is to evaluate the outcomes of COVID-19 patients with pre-existing CeVD. Read More

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http://dx.doi.org/10.1007/s00415-020-10141-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414251PMC