47,417 results match your criteria Ventilation Mechanical


Group B Streptococcus early-onset disease and observation of well-appearing newborns.

PLoS One 2019 20;14(3):e0212784. Epub 2019 Mar 20.

Terapia Intensiva Neonatale, Dipartimento Integrato Materno-Infantile, Azienda Ospedaliero-Universitaria Policlinico, Modena, Italy.

Background: International guidelines lack a substantial consensus regarding management of asymptomatic full-term and late preterm neonates at risk for early-onset disease (EOS). Large cohorts of newborns are suitable to increase the understanding of the safety and efficacy of a given strategy.

Methods: This is a prospective, area-based, cohort study involving regional birth facilities of Emilia-Romagna (Italy). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212784PLOS

High amplitude bubble continuous positive airway pressure decreases lung injury in rats with ventilator-induced lung injury.

J Chin Med Assoc 2019 Mar 11. Epub 2019 Mar 11.

Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ROC.

Background: Bubble continuous positive airway pressure (BCPAP) has been used in neonates with respiratory distress for decades; however, the optimal setting for BCPAP circuits remains unknown. This study compared the gas exchange efficiency and lung protection efficacy between conventional and high-amplitude BCPAP devices.

Methods: We compared gas exchange, lung volume, and pulmonary inflammation severity among rats with ventilator-induced lung injury (VILI) who were treated with conventional BCPAP (BCPAP with an expiratory limb at 0°), high-amplitude BCPAP (BCPAP with an expiratory limb at 135°), or spontaneous breathing (SB). Read More

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http://dx.doi.org/10.1097/JCMA.0000000000000070DOI Listing

Long-term ventilation for children with chronic lung disease of infancy.

Curr Opin Pediatr 2019 Mar 18. Epub 2019 Mar 18.

Section of Pulmonary Medicine and Pediatric Heart Lung Center, Department of Pediatrics, University of Colorado, School of Medicine, Aurora, Colorado, USA.

Purpose Of Review: Modern medical advances have resulted in an increased survival after extremely preterm birth. However, some infants will develop severe bronchopulmonary dysplasia (BPD) and fail to wean from invasive or noninvasive positive pressure support. It remains unclear which infants will benefit from tracheostomy placement for chronic ventilation. Read More

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http://dx.doi.org/10.1097/MOP.0000000000000757DOI Listing

Use of dexmedetomidine in pediatric cardiac anesthesia.

Curr Opin Anaesthesiol 2019 Mar 15. Epub 2019 Mar 15.

Department of Anesthesiology, Critical Care Medicine and Pain Therapy, University Hospital Münster, Münster, Germany.

Purpose Of Review: In recent years, ultrafast-track anesthesia with on-table extubation and concepts of accelerated postoperative care have gained increasing support in pediatric congenital cardiac surgery. It is believed that such approaches might ideally combine economic benefits with a striving for continuous improvement of patient outcomes. The present review summarizes the role of dexmedetomidine (DEX) in this setting. Read More

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http://dx.doi.org/10.1097/ACO.0000000000000731DOI Listing

Comparison of bronchial hygiene techniques in mechanically ventilated patients: a randomized clinical trial.

Rev Bras Ter Intensiva 2019 Mar 14. Epub 2019 Mar 14.

Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.

Objective: To compare the effects of vibrocompression and hyperinflation with mechanical ventilator techniques alone and in combination (hyperinflation with mechanical ventilator + vibrocompression) on the amount of aspirated secretion and the change in hemodynamic and pulmonary parameters.

Methods: A randomized clinical trial with critically ill patients on mechanical ventilation conducted in the intensive care unit of a university hospital. The patients were randomly allocated to receive one of the bronchial hygiene techniques for 10 minutes (vibrocompression or hyperinflation with mechanical ventilator or hyperinflation with mechanical ventilator + vibrocompression). Read More

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http://dx.doi.org/10.5935/0103-507X.20190005DOI Listing

Adequacy of enteral nutritional support in intensive care units does not affect the short- and long-term prognosis of mechanically ventilated patients: a pilot study.

Rev Bras Ter Intensiva 2019 Mar 14. Epub 2019 Mar 14.

Programa de Pós-Graduação em Ciências Pneumológicas, Universidade Federal do Rio Grande do Sul - Porto Alegre (RS), Brasil.

Objective: To correlate short-term (duration of mechanical ventilation and length of intensive care unit stay) and long-term (functional capacity) clinical outcomes of patients who reached nutritional adequacy ≥ 70% of predicted in the first 72 hours of hospitalization in the intensive care unit.

Methods: This was a prospective observational pilot study conducted in an 18-bed intensive care unit. A total of 100 mechanically ventilated patients receiving exclusive enteral nutritional support and receiving intensive care for more than 72 hours were included. Read More

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http://dx.doi.org/10.5935/0103-507X.20190004DOI Listing

A Woman with Asthma and Peripheral Ground-Glass Opacities.

Case Rep Pulmonol 2019 12;2019:9051381. Epub 2019 Feb 12.

Department of Internal Medicine, Section of pulmonary, Lincoln Medical Center, NY, USA.

Eosinophilic lung disease is a heterogeneous group of disorders that reveal eosinophil involved lung tissue often in patients with asthma or atopy. Classification and diagnostic criteria of eosinophilic lung disease are not well-established; however, peripheral ground-glass opacity is typical on chest computed tomography. Another etiology of this same radiographic finding reported in the literature is silicone embolism syndrome. Read More

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http://dx.doi.org/10.1155/2019/9051381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390235PMC
February 2019

Reply to «Materials engineering, mechanical power, protective ventilation and a parachute».

Med Intensiva 2019 Mar 16. Epub 2019 Mar 16.

Unidad de Cuidados Intensivos Pediátrica, Hospital Universitario Central de Asturias, Oviedo, Asturias, España.

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http://dx.doi.org/10.1016/j.medin.2019.01.007DOI Listing

Decreasing failed extubations with the implementation of an extubation checklist.

Am J Surg 2019 Mar 5. Epub 2019 Mar 5.

University of Texas at Austin Dell Medical School, USA; Dell Seton Medical Center at the University of Texas, Department of Trauma Services, USA. Electronic address:

Background: Failed extubation has been shown to increase ICU stay, transfers to rehabilitation facilities, and mortality. The purpose of this study was to assess the differences in rates of failed extubation before and after implementation of an extubation checklist.

Methods: We performed a retrospective study from January 2013-April 2017 on adult trauma patients (age 18-89) who were admitted to the ICU and required mechanical ventilation. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2019.02.028DOI Listing

Simultaneous Electrophysiological Recording and Self-powered Biosignal Monitoring using Epidermal, Nanotexturized, Triboelectronic Devices.

Nanotechnology 2019 Mar 19. Epub 2019 Mar 19.

Biomedical Engineering, Purdue University, West Lafayette, Indiana, UNITED STATES.

The fabrication of multifunctional epidermal electronic devices capable of efficiently reading electrophysiological signals and converting low-amplitude mechanical signals into electric outputs promises to pave the way towards the development of self-powered wearable sensors, smart consumer electronics, and human-machine interfaces. This article describes the scalable and cost-effective fabrication of epidermal, nanotexturized, triboelectronic devices (EnTDs). EnTDs can be conformably worn onto the skin and efficiently monitor electrophysiological signals, temperature, and hydration levels. Read More

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http://dx.doi.org/10.1088/1361-6528/ab10e9DOI Listing

High flow nasal cannula compared with conventional oxygen therapy for acute hypoxemic respiratory failure: a systematic review and meta-analysis.

Intensive Care Med 2019 Mar 19. Epub 2019 Mar 19.

Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.

Background: This systematic review and meta-analysis summarizes the safety and efficacy of high flow nasal cannula (HFNC) in patients with acute hypoxemic respiratory failure.

Methods: We performed a comprehensive search of MEDLINE, EMBASE, and Web of Science. We identified randomized controlled trials that compared HFNC to conventional oxygen therapy. Read More

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http://dx.doi.org/10.1007/s00134-019-05590-5DOI Listing

Differences in Particle Deposition Between Members of Imaging-Based Asthma Clusters.

J Aerosol Med Pulm Drug Deliv 2019 Mar 19. Epub 2019 Mar 19.

1 Department of Mechanical Engineering and The University of Iowa, Iowa City, Iowa.

Background: Four computed tomography (CT) imaging-based clusters have been identified in a study of the Severe Asthma Research Program (SARP) cohort and have been significantly correlated with clinical and demographic metrics (J Allergy Clin Immunol 2017; 140:690-700.e8). We used a computational fluid dynamics (CFD) model to investigate air flow and aerosol deposition within imaging archetypes representative of the four clusters. Read More

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http://dx.doi.org/10.1089/jamp.2018.1487DOI Listing

Brainstem Anaesthesia after Retrobulbar Block.

Open Med (Wars) 2019 2;14:287-291. Epub 2019 Mar 2.

Medical Faculty, University of Ljubljana, Ljubljana, Slovenia.

Regional anaesthesia techniques in ophthalmology are usually utilized for day case surgery. During various procedures, profound akinesia of the eye and anaesthesia of the surgical site are required, both of which are achieved with retrobulbar block. Due to the anatomy of the eye, life-threatening complications are possible. Read More

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http://dx.doi.org/10.1515/med-2019-0025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419387PMC

Effects of Budesonide Combined with Noninvasive Ventilation on PCT, sTREM-1, Chest Lung Compliance, Humoral Immune Function and Quality of Life in Patients with AECOPD Complicated with Type II Respiratory Failure.

Open Med (Wars) 2019 2;14:271-278. Epub 2019 Mar 2.

Department of Emergency, 1st Hospital of Yulin, Yulin City, Shaanxi Province 719000, China.

Objective: Our objective is to explore the effects of budesonide combined with noninvasive ventilation on procalcitonin (PCT), soluble myeloid cell triggering receptor-1 (sTREM-1), thoracic and lung compliance, humoral immune function, and quality of life in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) complicated with type II respiratory failure.

Methods: There were 82 patients with AECOPD complicated with type II respiratory failure admitted into our hospital between March, 2016-September, 2017. They were selected and randomly divided into observation group (n=41) and control group (n=41). Read More

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http://dx.doi.org/10.1515/med-2019-0023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419390PMC

Bacterial and viral respiratory tract microbiota and host characteristics in children with lower respiratory tract infections: a matched case-control study.

Lancet Respir Med 2019 Mar 15. Epub 2019 Mar 15.

Department of Paediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital and University Medical Center Utrecht, Utrecht, Netherlands; Medical Research Council and University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK. Electronic address:

Background: Lower respiratory tract infections (LRTIs) are a leading cause of childhood morbidity and mortality. Potentially pathogenic organisms are present in the respiratory tract in both symptomatic and asymptomatic children, but their presence does not necessarily indicate disease. We aimed to assess the concordance between upper and lower respiratory tract microbiota during LRTIs and the use of nasopharyngeal microbiota to discriminate LRTIs from health. Read More

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http://dx.doi.org/10.1016/S2213-2600(18)30449-1DOI Listing

Ventilatory setting in Adult Respiratory Distress Syndrome: Don't listen the sound of Sirens! But keep some dreams in your mind….

Anaesth Crit Care Pain Med 2019 Apr;38(2):91-93

Department of perioperative medicine, University Hospital of Clermont-Ferrand, France; Department of Anaesthesia and critical-care, Sorbonne Université, Hôpital Pitié-Salpêtrière, Assistance publique-hôpitaux de Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.accpm.2019.03.001DOI Listing

Performance enhancement of hybrid personal cooling clothing in a hot environment: PCM cooling energy management with additional insulation.

Ergonomics 2019 Mar 18:1-27. Epub 2019 Mar 18.

a Institute of Textiles and Clothing, The Hong Kong Polytechnic University , Hong Kong , China.

A novel design of personal cooling clothing incorporating additional insulation sandwiched between PCMs and clothing outer layer is proposed. Performance of four personal cooling systems including clothing with only PCMs (PCM), clothing with PCMs and insulation (PCM + INS), clothing with PCMs and ventilation fans (HYB), and clothing with PCMs, ventilation fans & insulation (HYB + INS) was investigated. Effect of additional insulation on clothing cooling performance in terms of human physiological and perceptual responses was also examined. Read More

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http://dx.doi.org/10.1080/00140139.2019.1596318DOI Listing

Delayed onset pulmonary edema following toxic smoke inhalation; a systematic review.

Acute Med 2018 ;17(4):203-211

Department of Emergency Medicine, Odense University Hospital, Sdr. Boulevard 29, DK-5000 Odense C, Denmark.

Background: Fire smoke inhalation cause a wide range of symptoms immediately or after a relatively asymptomatic period. In this review, we will focus on delayed onset pulmonary edema (DOPE); the incidence and duration of potential delay. As the symptoms may not present immediately, seemingly healthy patients could be inadvertently be sent home. Read More

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January 2018

A coupled approach for identification of nonlinear and compressible material models for soft tissue based on different experimental setups - Exemplified and detailed for lung parenchyma.

J Mech Behav Biomed Mater 2019 Feb 20;94:126-143. Epub 2019 Feb 20.

Institute for Computational Mechanics, Technical University of Munich, Boltzmannstr. 15, 85747 Garching b. München, Germany.

In this paper, a coupled inverse analysis is proposed to identify nonlinear compressible hyperelastic material models described by two sets of experiments. While the overall approach is applicable for different materials, here it will be presented for viable lung parenchyma. Characterizing the material properties of lung parenchyma is essential to describe and predict the mechanical behavior of the respiratory system in health and disease. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.02.019DOI Listing
February 2019

Noninvasive ventilation in critically ill patients with the Middle East respiratory syndrome.

Influenza Other Respir Viruses 2019 Mar 18. Epub 2019 Mar 18.

Intensive Care Department, King Abdullah International Medical Research Center, College of Medicine, King Abdulaziz Medical City, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Background: Noninvasive ventilation (NIV) has been used in patients with the Middle East respiratory syndrome (MERS) with acute hypoxemic respiratory failure, but the effectiveness of this approach has not been studied.

Methods: Patients with MERS from 14 Saudi Arabian centers were included in this analysis. Patients who were initially managed with NIV were compared to patients who were managed only with invasive mechanical ventilation (invasive MV). Read More

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http://dx.doi.org/10.1111/irv.12635DOI Listing

Long-term Cognitive and Functional Impairments After Critical Illness.

Anesth Analg 2019 Apr;128(4):772-780

From the Department of Anesthesiology, Division of Anesthesiology Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.

As critical illness survivorship increases, patients and health care providers are faced with management of long-term sequelae including cognitive and functional impairment. Longitudinal studies have demonstrated impairments persisting at least 1-5 years after hospitalization for critical illness. Cognitive domains impacted include memory, attention, and processing speed. Read More

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http://dx.doi.org/10.1213/ANE.0000000000004066DOI Listing
April 2019
1 Read

Coronary Angiography after Cardiac Arrest without ST-Segment Elevation.

N Engl J Med 2019 Mar 18. Epub 2019 Mar 18.

From the Departments of Cardiology (J.S.L., G.N.J., N.W.H., N.R.), Intensive Care Medicine (P.W.G.E., H.M.O.-S.), and Epidemiology and Biostatistics (P.M.V.), Amsterdam University Medical Center VUmc, the Departments of Cardiology (J.P.H.) and Intensive Care Medicine (A.P.J.V.), Amsterdam University Medical Center AMC, and the Departments of Cardiology (M.A.V.) and Intensive Care Medicine (B.B.), Onze Lieve Vrouwe Gasthuis, Amsterdam, the Thorax Center, Erasmus Medical Center (L.S.D.J., E.A.D.), and the Departments of Cardiology (G.J.V.) and Intensive Care Medicine (B.J.W.E.), Maasstad Hospital, Rotterdam, the Departments of Cardiology (M. Meuwissen) and Intensive Care Medicine (T.A.R.), Amphia Hospital, Breda, the Departments of Cardiology (H.A.B.) and Intensive Care Medicine (M.J.B.), Rijnstate Hospital, Arnhem, the Departments of Cardiology (G.B.B.) and Intensive Care Medicine (R.B.), Haga Hospital, and the Department of Cardiology, Haaglanden Medical Center (P.V.O.), The Hague, the Departments of Cardiology (P.H.) and Intensive Care Medicine (I.C.C.H.), University of Groningen, Groningen, the Departments of Cardiology (M.V.) and Intensive Care Medicine (J.J.H.), University Medical Center Utrecht, Utrecht, the Departments of Intensive Care Medicine (A.B.) and Cardiology (M.S.), Medisch Spectrum Twente, Enschede, the Departments of Cardiology (C.C., N.R.) and Intensive Care Medicine (H.H.), Radboud University Medical Center, Nijmegen, the Departments of Cardiology (T.A.C.M.H.) and Intensive Care Medicine (W.R.), Noordwest Ziekenhuisgroep, Alkmaar, the Departments of Intensive Care Medicine (T.S.R.D.) and Cardiology (H.J.G.M.C.), Maastricht University Medical Center, Maastricht, the Department of Cardiology, Scheper Hospital, Emmen (G.A.J.J.), the Department of Cardiology, Isala Hospital, Zwolle (M.T.M.G.), the Department of Cardiology, Tergooi Hospital, Blaricum (K.P.), and the Department of Cardiology, Elisabeth-Tweesteden Hospital, Tilburg (M. Magro) - all in the Netherlands.

Background: Ischemic heart disease is a major cause of out-of-hospital cardiac arrest. The role of immediate coronary angiography and percutaneous coronary intervention (PCI) in the treatment of patients who have been successfully resuscitated after cardiac arrest in the absence of ST-segment elevation myocardial infarction (STEMI) remains uncertain.

Methods: In this multicenter trial, we randomly assigned 552 patients who had cardiac arrest without signs of STEMI to undergo immediate coronary angiography or coronary angiography that was delayed until after neurologic recovery. Read More

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http://dx.doi.org/10.1056/NEJMoa1816897DOI Listing

Outcomes of unplanned extubation in ordinary ward are similar to those in intensive care unit: A STROBE-compliant case-control study.

Medicine (Baltimore) 2019 Mar;98(11):e14841

Division of Respiratory Therapy.

Unplanned extubation (UE) may cause considerable adverse effects in patients receiving mechanical ventilation (MV). Previous literature showed inconsistent prognosis in patients with UE. This study aimed to evaluate the clinical implications and outcomes of UE. Read More

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http://dx.doi.org/10.1097/MD.0000000000014841DOI Listing

Does chronic obstructive pulmonary disease relate to poor prognosis in patients with lung cancer?: A meta-analysis.

Medicine (Baltimore) 2019 Mar;98(11):e14837

The Second Affiliated Hospital, School of Medicine.

Background: Nowadays, there is growing recognition that chronic obstructive pulmonary disease (COPD) may have influence on lung cancer. However, coexisted COPD related to prognosis of lung cancer is still elusive. We conducted this meta-analysis to examine the association between COPD and 5-year overall survival (OS) and postoperative pulmonary complications of patients with lung cancer. Read More

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http://dx.doi.org/10.1097/MD.0000000000014837DOI Listing

ABCDE and ABCDEF care bundles: A systematic review protocol of the implementation process in intensive care units.

Medicine (Baltimore) 2019 Mar;98(11):e14792

Graduate Program in Pharmaceutical Sciences, University of Sorocaba, Sorocaba, São Paulo.

Background: The awakening and breathing coordination of daily sedation and ventilator removal trials, delirium monitoring and management, and early mobility and exercise (ABCDE) and assessment, prevent and manage pain, both spontaneous awakening and spontaneous breathing trials, choice of analgesia and sedation, assess, prevent and manage delirium, early mobility and exercise, family engagement (ABCDEF) bundles are part of the science of the liberation of the intensive care unit (ICU). There are not enough studies that have evaluated the effectiveness and safety of the implementation of these bundles. This study will analyze the implementation process, estimate their effectiveness and safety, and identify barriers, facilitators and attitudes that have influenced the implementation process. Read More

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http://Insights.ovid.com/crossref?an=00005792-201903150-0003
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http://dx.doi.org/10.1097/MD.0000000000014792DOI Listing
March 2019
1 Read

Effect of Neurally Adjusted Ventilatory Assist on Patient-Ventilator Interaction in Mechanically Ventilated Adults: A Systematic Review and Meta-Analysis.

Crit Care Med 2019 Mar 15. Epub 2019 Mar 15.

Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada.

Objectives: Patient-ventilator asynchrony is common among critically ill patients undergoing mechanical ventilation and has been associated with adverse outcomes. Neurally adjusted ventilatory assist is a ventilatory mode that may lead to improved patient-ventilator synchrony. We conducted a systematic review to determine the impact of neurally adjusted ventilatory assist on patient-ventilator asynchrony, other physiologic variables, and clinical outcomes in adult patients undergoing invasive mechanical ventilation in comparison with conventional pneumatically triggered ventilatory modes. Read More

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http://dx.doi.org/10.1097/CCM.0000000000003719DOI Listing

Pneumonia-Specific Escherichia coli with Distinct Phylogenetic and Virulence Profiles, France, 2012-2014.

Emerg Infect Dis 2019 Apr;25(4):710-718

In a prospective, nationwide study in France of Escherichia coli responsible for pneumonia in patients receiving mechanical ventilation, we determined E. coli antimicrobial susceptibility, phylotype, O-type, and virulence factor gene content. We compared 260 isolates with those of 2 published collections containing commensal and bacteremia isolates. Read More

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http://dx.doi.org/10.3201/eid2504.180944DOI Listing

A Case of Bilateral Spontaneous Chylothorax with Respiratory Syncytial Virus Bronchiolitis.

Case Rep Pediatr 2019 6;2019:2853632. Epub 2019 Feb 6.

Division of Critical Care Medicine, Le Bonheur Children's Hospital, University of Tennessee Health Science Center, Memphis, TN, USA.

A case of bilateral spontaneous chylothorax with respiratory syncytial virus (RSV) bronchiolitis has never been reported. We report the case of a 7-month-old boy born at 33 weeks gestation with a history of Down syndrome, atrial septal defect, pulmonary hypertension, and chronic lung disease, hospitalized due to RSV bronchiolitis who developed bilateral spontaneous chylothorax with exacerbation of pulmonary hypertension (PH). The patient died after 9 weeks of mechanical ventilation and treatment for PH. Read More

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http://dx.doi.org/10.1155/2019/2853632DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381583PMC
February 2019

The Crashing Obese Patient.

West J Emerg Med 2019 Mar 6;20(2):323-330. Epub 2019 Feb 6.

University of Maryland School of Medicine, Department of Emergency Medicine, Baltimore, Maryland.

Emergency physicians (EP) frequently resuscitate and manage critically ill patients. Resuscitation of the crashing obese patient presents a unique challenge for even the most skilled physician. Changes in anatomy, metabolic demand, cardiopulmonary reserve, ventilation, circulation, and pharmacokinetics require special consideration. Read More

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https://escholarship.org/uc/item/4nd1w8r4
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http://dx.doi.org/10.5811/westjem.2018.12.41085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404698PMC
March 2019
1 Read

Risk factor analysis of pneumothorax associated with persistent pulmonary hypertension of the newborn in Thai neonates.

J Matern Fetal Neonatal Med 2019 Mar 17:1-11. Epub 2019 Mar 17.

a Department of Pediatrics , Hat Yai Medical Education Center , Hat Yai Hospital , Hat Yai , Thailand.

Objective: To determine the risk factors and outcomes of persistent pulmonary hypertension of the newborn (PPHN)-associated pneumothorax (PTX).

Study Design: The medical records of infants diagnosed with PPHN with or without PTX from January 2012 to July 2017 were retrospectively reviewed.

Results: Of the 102 included PPHN infants, PTX was found in 32 (31. Read More

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http://dx.doi.org/10.1080/14767058.2019.1596403DOI Listing

Crotalus durissus terrificus (viperidae; crotalinae) envenomation: Respiratory failure and treatment with antivipmyn TRI antivenom.

Toxicon 2019 Mar 14. Epub 2019 Mar 14.

Department of Experimental & Clinical Pharmacology, University of Minnesota, Minneapolis, MN, 55455, USA. Electronic address:

We report an envenomation to a professional herpetologist by a South American rattlesnake (Crotalus durissus terrificus) that resulted in respiratory failure, and therapeutic improvement following antivenom administration. A 56-year-old male was bitten on the left wrist by a Crotalus durissus terrificus (C. d. Read More

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http://dx.doi.org/10.1016/j.toxicon.2019.03.009DOI Listing

Transfection of Sox11 plasmid alleviates ventilator-induced lung injury via Sox11 and FAK.

Biochem Biophys Res Commun 2019 Mar 14. Epub 2019 Mar 14.

Department of Pathophysiology, Neuroscience Research Center, Hebei Medical University, Shijiazhuang, China. Electronic address:

Background Ventilator-induced lung injury (VILI) is the most common complication in the mechanical ventilation in clinic. The pathogenesis of VILI has not been well understood. The SRY related High Mobility Group box group-F family member 11(Sox11) is a protein associated with lung development. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.03.041DOI Listing

Analysis of Intrahospital Mortality in Patients With Lung Transplant Due to Diffuse Parenchymal Lung Disease.

Transplant Proc 2019 Mar 30;51(2):372-375. Epub 2018 Oct 30.

Department of Respiratory Medicine, Transplant Unit Hospital Universitario 12 de Octubre, Madrid, Spain.

Background: Patients with diffuse parenchymal lung disease (DPLD) have the poorest survival rates both before and after lung transplantation (LT). Early mortality among LT patients as a result of DLPD is estimated at 10% to 20%. The aim of the study was to assess intrahospital mortality after LT procedures for DLPD and to identify factors in the recipient, donor, intra- and postoperative periods that might improve early outcomes. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.10.020DOI Listing
March 2019
1 Read

Sound regulation of coupled Helmholtz and Fabry-Pérot resonances in labyrinth cavity structures.

Ultrasonics 2019 Mar 6;95:45-51. Epub 2019 Mar 6.

Key Laboratory of Modern Acoustics, MOE, School of Physics, Nanjing University, Nanjing 210093, PR China.

Traditional acoustic regulations in practice are used to have major obstacles in low frequency range, for which absorbers or suppressors have thicknesses that are comparable to their working wavelength. We present an acoustic structure-based "coiling-up space" to achieve outstanding sound regulation of acoustic waves in the extremely low frequency region. The structure is composed of an open waveguide and with a spiral throat tube and a cavity. Read More

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http://dx.doi.org/10.1016/j.ultras.2019.03.007DOI Listing

Differences in neurosurgical treatment of intracerebral haemorrhage: a nation-wide observational study of 578 consecutive patients.

Acta Neurochir (Wien) 2019 Mar 15. Epub 2019 Mar 15.

Department of Neuroscience, Neurosurgery, Uppsala University, Uppsala University Hospital, SE-751 85, Uppsala, Sweden.

Background: Supratentorial intracerebral haemorrhage (ICH) carries an excessive mortality and morbidity. Although surgical ICH treatment can be life-saving, the indications for surgery in larger cohorts of ICH patients are controversial and not well defined. We hypothesised that surgical indications vary substantially among neurosurgical centres in Sweden. Read More

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http://dx.doi.org/10.1007/s00701-019-03853-0DOI Listing

Implementation of a nurse-driven ventilation weaning protocol in critically ill children: Can it improve patient outcome?

Aust Crit Care 2019 Mar 12. Epub 2019 Mar 12.

Intensive Care, Erasmus MC - Sophia Children's Hospital Rotterdam, the Netherlands.

Background: Critically ill children treated with invasive mechanical ventilation in a paediatric intensive care unit (PICU) may suffer from complications leading to prolonged duration of ventilation and PICU stay.

Objective: The objective of this study is to find out if the use of a nurse-driven ventilation weaning protocol in a PICU can shorten the duration of mechanical ventilation.

Methods: In a prospective, pretest-posttest implementation study, we implemented a nurse-driven ventilation weaning protocol and compared its outcomes with those of the usual physician-driven weaning. Read More

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http://dx.doi.org/10.1016/j.aucc.2019.01.005DOI Listing
March 2019
1 Read

Subglottic stenosis in children: Our experience at a pediatric tertiary center for 8 years in South Korea.

Int J Pediatr Otorhinolaryngol 2019 Feb 27;121:64-67. Epub 2019 Feb 27.

Department of Otolaryngology - Head and Neck Surgery, College of Medicine and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, South Korea. Electronic address:

Objective: The incidence of SGS has been reported to be less than 8% after endotracheal intubation. Therefore there is an increasing trend in the number of patients with acute acquired SGS due to mechanical ventilation in the intensive care unit. However, there have been no reports describing the treatment of SGS in children in South Korea. Read More

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http://dx.doi.org/10.1016/j.ijporl.2019.02.044DOI Listing
February 2019
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Changes in Electrical Impedance Tomography Findings of ICU Patients during Rapid Infusion of a Fluid Bolus: A Prospective Observational Study.

Am J Respir Crit Care Med 2019 Mar 15. Epub 2019 Mar 15.

University Medical Centre Schleswig-Holstein, Department of Anaesthesiology and Intensive Care Medicine, Kiel, Germany.

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http://dx.doi.org/10.1164/rccm.201812-2252LEDOI Listing
March 2019
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Mechanosensing and Mechanoregulation of Endothelial Cell Functions.

Compr Physiol 2019 Mar 15;9(2):873-904. Epub 2019 Mar 15.

Department of Anesthesiology, University of Maryland Baltimore School of Medicine, Baltimore, Maryland, USA.

Vascular endothelial cells (ECs) form a semiselective barrier for macromolecules and cell elements regulated by dynamic interactions between cytoskeletal elements and cell adhesion complexes. ECs also participate in many other vital processes including innate immune reactions, vascular repair, secretion, and metabolism of bioactive molecules. Moreover, vascular ECs represent a unique cell type exposed to continuous, time-dependent mechanical forces: different patterns of shear stress imposed by blood flow in macrovasculature and by rolling blood cells in the microvasculature; circumferential cyclic stretch experienced by the arterial vascular bed caused by heart propulsions; mechanical stretch of lung microvascular endothelium at different magnitudes due to spontaneous respiration or mechanical ventilation in critically ill patients. Read More

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http://dx.doi.org/10.1002/cphy.c180020DOI Listing

Acute respiratory distress syndrome.

Nat Rev Dis Primers 2019 Mar 14;5(1):18. Epub 2019 Mar 14.

Cardiovacular Research Institute, University of California-San Francisco, San Francisco, CA, USA.

The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema, hypoxaemia and the need for mechanical ventilation. ARDS occurs most often in the setting of pneumonia, sepsis, aspiration of gastric contents or severe trauma and is present in ~10% of all patients in intensive care units worldwide. Despite some improvements, mortality remains high at 30-40% in most studies. Read More

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http://dx.doi.org/10.1038/s41572-019-0069-0DOI Listing

Temporal trends and outcomes of prolonged invasive mechanical ventilation and tracheostomy use in acute myocardial infarction with cardiogenic shock in the United States.

Int J Cardiol 2019 Mar 6. Epub 2019 Mar 6.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, United States of America.

Background: There are limited data on prolonged invasive mechanical ventilation (IMV) and tracheostomy use in intubated acute myocardial infarction with cardiogenic shock (AMI-CS) patients.

Methods: Using the National Inpatient Sample, all admissions with AMI-CS requiring IMV between January 1, 2000, and December 31, 2014, were included. Prolonged IMV was defined as IMV use >96 h. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01675273183717
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http://dx.doi.org/10.1016/j.ijcard.2019.03.008DOI Listing
March 2019
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The effects and safety of vasopressin receptor agonists in patients with septic shock: a meta-analysis and trial sequential analysis.

Crit Care 2019 Mar 14;23(1):91. Epub 2019 Mar 14.

Department of Emergency Medicine, Second Affiliated Hospital, School of Medicine & Institute of Emergency Medicine, Zhejiang University, No 88, Jiefang Rd, Hangzhou, China.

Background: The aim of this study was to evaluate the effects and safety of vasopressin receptor agonists in patients with septic shock.

Methods: PubMed, EMBASE, and Cochrane library were searched for randomized controlled trials evaluating the effects of vasopressin receptor agonists in septic shock patients. Two reviewers performed literature selection, data extraction, and quality evaluation independently. Read More

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http://dx.doi.org/10.1186/s13054-019-2362-4DOI Listing
March 2019
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Pneumonia in severely injured patients with thoracic trauma: results of a retrospective observational multi-centre study.

Scand J Trauma Resusc Emerg Med 2019 Mar 14;27(1):31. Epub 2019 Mar 14.

Department of Trauma and Reconstructive Surgery, University Hospital RWTH Aachen, Pauwelsstraße 30, D-52074, Aachen, Germany.

Background: While the incidence and aspects of pneumonia in ICU patients has been extensively discussed in the literature, studies on the occurrence of pneumonia in severely injured patients are rare. The aim of the present study is to elucidate factors associated with the occurrence of pneumonia in severely injured patients with thoracic trauma.

Setting: Level-I University Trauma Centres associated with the TraumaRegister DGU®. Read More

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http://dx.doi.org/10.1186/s13049-019-0608-4DOI Listing

Effects of a physiotherapic program in patients on veno-venous extracorporeal membrane oxygenation. A 8 year single center experience.

Minerva Anestesiol 2019 Mar 12. Epub 2019 Mar 12.

Intensive Care Unit and Regional ECMO Referral Centre, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

Background: To date, there is no agreement on the timing to perform a physical session in patients on Veno-Venous Extracorporeal Membrane Oxygenation (VV-ECMO). We aimed to assess whether early physiotherapy (within the first week from ECMO start) could affect in-ICU mortality.

Methods: Our retrospective observational study included 101 adults supported on VV ECMO from 2009 to 2016, consecutively admitted at our ECMO referral Center in Florence (Italy). Read More

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http://dx.doi.org/10.23736/S0375-9393.19.13287-7DOI Listing
March 2019
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An in-vitro study to evaluate high-volume low-pressure endotracheal tube cuff deflation dynamics.

Minerva Anestesiol 2019 Mar 12. Epub 2019 Mar 12.

Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Background: High-volume low-pressure (HVLP) endotracheal tube (ETT) cuffs for critically ill patients often deflate during the course of mechanical ventilation. We performed an in-vitro study to comprehensively assess HVLP cuff deflation dynamics and potential preventive measures.

Methods: We evaluated 24-h deflation of 7 HVLP cuffs of cylindrical or tapered shape, and made of polyvinylchloride or polyurethane. Read More

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http://dx.doi.org/10.23736/S0375-9393.19.13133-1DOI Listing
March 2019
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Sevoflurane sedation for weaning from mechanical ventilation in pediatric intensive care unit.

Minerva Anestesiol 2019 Mar 12. Epub 2019 Mar 12.

Department of Pediatric Surgery and Intensive Care, University Medical Center Ljubljana, Ljubljana, Slovenia.

Background: Light sedation is the prerequisite for weaning from mechanical ventilation. Our aim was to evaluate the technical feasibility and efficacy of sevoflurane delivered by anesthetic conserving device (ACD) for sedation of children during weaning from mechanical ventilation.

Methods: Prospective observational feasibility study in paediatric ICU. Read More

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http://dx.doi.org/10.23736/S0375-9393.19.13077-5DOI Listing
March 2019
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Mechanical Ventilation in Acute Respiratory Distress Syndrome: Time Heals All Wounds, or Does It?

Anesthesiology 2019 Mar 11. Epub 2019 Mar 11.

From the Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada (L.D.S., A.S.S.) University Health Network, Toronto General Hospital, Toronto, Ontario, Canada (L.D.S.) Department of Medicine and Physiology, Mayo Clinic, Rochester, Minnesota (R.H.) Department of Medicine, University of Minnesota, Minneapolis, Minnesota (R.H.) Keenan Research Center, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada (A.S.S.).

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http://dx.doi.org/10.1097/ALN.0000000000002671DOI Listing
March 2019
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Gradually Increasing Tidal Volume May Mitigate Experimental Lung Injury in Rats.

Anesthesiology 2019 Mar 11. Epub 2019 Mar 11.

From the Laboratory of Pulmonary Investigation, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil (N.S.F., C.S.S., F.F.C., N.N.R., M.V.S.F., J.A.M., R.L.B.-M., P.L.S., P.R.M.R.) the Department of Physiology and Pharmacology, Biomedical Institute, Fluminense Federal University, Niteroi, Brazil (N.N.R.) the Department of Pathology, School of Medicine, University of São Paulo, São Paulo, Brazil (V.L.C.) the Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy (P.P.) Istituto di Ricovero e Cura a Carattere Scientifico Ospedale San Martino, Genoa, Italy (P.P.) Regions Hospital and University of Minnesota, Minneapolis/Saint Paul, Minnesota (J.J.M.).

What We Already Know About This Topic: High tidal volumes and pressures may worsen acute lung injury, sometimes resulting in a trade-off between inflicted damage versus inadequate ventilation WHAT THIS ARTICLE TELLS US THAT IS NEW: In a rat model of experimental lung injury, gradually increasing tidal volume to a known injurious level may result in less (or in some circumstances, more) damage BACKGROUND:: This study hypothesized that, in experimental mild acute respiratory distress syndrome, lung damage caused by high tidal volume (VT) could be attenuated if VT increased slowly enough to progressively reduce mechanical heterogeneity and to allow the epithelial and endothelial cells, as well as the extracellular matrix of the lung to adapt. For this purpose, different strategies of approaching maximal VT were tested.

Methods: Sixty-four Wistar rats received Escherichia coli lipopolysaccharide intratracheally. Read More

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http://dx.doi.org/10.1097/ALN.0000000000002630DOI Listing
March 2019
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[Bullous pneumonia secondary to Elizabethkingia meningoseptica, its clinical and radiological evolution].

Arch Argent Pediatr 2019 Apr;117(2):e150-e154

Servicio de Neumonología, Hospital de Pediatría "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina.

Elizabethkingia meningoseptica is an opportunistic pathogen with a high mortality and an increasing incidence in the intensive care units. We present a 4-year-old patient with a history of atresia of the biliary tract and a liver transplant at 11 months of age, who was admitted for acute respiratory infection with hypoxemia. During the hospitalization, she required mechanical ventilation. Read More

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http://dx.doi.org/10.5546/aap.2019.e150DOI Listing
April 2019
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Prevalence of extubation and associated risk factors at a tertiary care pediatric intensive care unit.

Arch Argent Pediatr 2019 Apr;117(2):87-93

Hospital de Pediatría SAMIC "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina.

Introduction: Extubation failure (EF) is associated with a higher risk for pneumonia, hospital stay, and mortality.

Objective: To determine the prevalence of EF and identify the associated factors in our population.

Materials And Methods: Observational and retrospective design. Read More

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http://dx.doi.org/10.5546/aap.2019.eng.87DOI Listing
April 2019
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