28,872 results match your criteria Ventilation Management


Airway clearance, mucoactive therapies and pulmonary rehabilitation in bronchiectasis.

Respirology 2019 Jan 16. Epub 2019 Jan 16.

The Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Belfast, UK.

This paper aims to provide physiological rationale for airway clearance, mucoactive therapy and pulmonary rehabilitation (PR) (or exercise interventions) in bronchiectasis. There is increasing emphasis on the role of airway clearance techniques (ACT) in the management of bronchiectasis. No single ACT has currently shown superior effect over another. Read More

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http://dx.doi.org/10.1111/resp.13459DOI Listing
January 2019

Hypercapnic acidosis induces mitochondrial dysfunction and impairs the ability of mesenchymal stem cells to promote distal lung epithelial repair.

FASEB J 2019 Jan 16:fj201802056R. Epub 2019 Jan 16.

Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University of Belfast, Belfast, United Kingdom.

Acute respiratory distress syndrome (ARDS) is a devastating disorder characterized by diffuse inflammation and edema formation. The main management strategy, low tidal volume ventilation, can be associated with the development of hypercapnic acidosis (HCA). Mesenchymal stem cells (MSCs) are a promising therapeutic candidate currently in early-phase clinical trials. Read More

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http://dx.doi.org/10.1096/fj.201802056RDOI Listing
January 2019

Impact of Prosthodontic Treatment on the Oral Health-related Quality of Life in Mucormycosis Patient: A Case Report.

Cureus 2018 Oct 24;10(10):e3493. Epub 2018 Oct 24.

Prosthodontics, Sri Ramachandra University, Chennai, IND.

Mucormycosis is a fulminant fungal infection that occurs most often in diabetic and immunocompromised patients, including those with hematologic malignancies. Patients with maxillary resections present a challenge situation for the maxillofacial prosthodontist. Prosthodontic rehabilitation of such patients presents a significant challenge in restoring speech, deglutition and mastication, and respiration. Read More

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http://dx.doi.org/10.7759/cureus.3493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6318130PMC
October 2018

Case Report: Post obstructive pulmonary edema (POPE) Type II following elective adenotonsillectomy requiring novel use of high frequency oscillatory ventilation (HFOV).

F1000Res 2018 31;7:1373. Epub 2018 Aug 31.

Department of Pediatric Anesthesia, Alberta Children's Hospital, Calgary, Alberta, T3B 6A8, Canada.

This case report describes a previously healthy 14 year-old patient undergoing elective outpatient adenotonsillectomy that was complicated by acute postoperative pulmonary edema requiring 12 hours of high frequency oscillatory ventilation (HFOV) support.  We describe the clinical findings that led us to this rare diagnosis and management of post obstructive pulmonary edema (POPE) Type II, a rare but recognized complication following the surgical relief of an upper airway obstruction. This case is unique in that no previously published case report or review of POPE Type II has described the need for HFOV support. Read More

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http://dx.doi.org/10.12688/f1000research.16044.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325615PMC

Breathe Easy EDA: A MATLAB toolbox for psychophysiology data management, cleaning, and analysis.

F1000Res 2018 22;7:216. Epub 2018 Feb 22.

Department Psychology, Boston College, Chestnut Hill, MA, USA.

Electrodermal activity (EDA) recordings are widely used in experimental psychology to measure skin conductance responses (SCRs) that reflect sympathetic nervous system arousal. However, irregular respiration patterns and deep breaths can cause EDA fluctuations that are difficult to distinguish from genuine arousal-related SCRs, presenting a methodological challenge that increases the likelihood of false positives in SCR analyses. Thus, it is crucial to identify respiration-related artifacts in EDA data. Read More

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http://dx.doi.org/10.12688/f1000research.13849.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317497PMC
February 2018

Management of Acute Respiratory Failure Due to Community-Acquired Pneumonia: A Systematic Review.

Med Sci (Basel) 2019 Jan 14;7(1). Epub 2019 Jan 14.

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Internal Medicine Department, Respiratory unit and Adult Cystic Fibrosis Center, 20122 Milan, Italy.

Community-acquired pneumonia (CAP) is a leading cause of mortality worldwide. CAP mortality is driven by the development of sepsis and acute respiratory failure (ARF). We performed a systematic review of the available English literature published in the period 1 January 1997 to 31 August 2017 and focused on ARF in CAP. Read More

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http://dx.doi.org/10.3390/medsci7010010DOI Listing
January 2019

[Diet optimization in patients with obesity and diastolic heart failure based on the assessment of indicators of metabolism during physical exertion].

Vopr Pitan 2017 28;86(1):48-57. Epub 2016 Dec 28.

Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow.

The objective of the work was to examine the performance of basal metabolism and body composition in obese patients with diastolic heart failure (DHF) to identify optimal needs of these patients in the nutrients and energy. We studied 222 patients with obesity, that were divided into four groups depending on the degree of obesity and the presence or absence of DHF with preserved systolic function of the left ventricle (2 groups of obese patients with an initial degree I-II, 2 groups - a pronounced degree of obesity III). Basal metabolism by indirect respiratory calorimetry, physical activity at home and cardiorespiratory exercise testing were evaluated in these groups of patients. Read More

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http://dx.doi.org/10.24411/0042-8833-2017-00020DOI Listing
December 2016

[Peculiarities of disorders in physical development of children consuming drinking water with increased nitrate content].

Vopr Pitan 2017 2;86(3):40-48. Epub 2017 May 2.

Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm'.

Peculiarities of physical development disorders in 334 children were examined in the course of comparative clinical-laboratory research; all these children consumed drinking water with various nitrates content (11.2±1.1 mg/l and up to 3. Read More

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http://dx.doi.org/10.24411/0042-8833-2017-00043DOI Listing

Venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta-analysis.

Lancet Respir Med 2019 Jan 11. Epub 2019 Jan 11.

Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada; University Health Network and Sinai Health System, Toronto, ON Canada.

Background: Use of extracorporeal membrane oxygenation (ECMO) in adults with severe acute respiratory distress syndrome has increased in the past 10 years. However, the efficacy of venovenous ECMO in people with acute respiratory distress syndrome is uncertain according to the most recent data. We aimed to estimate the effect of venovenous ECMO on mortality from acute respiratory distress syndrome. Read More

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http://dx.doi.org/10.1016/S2213-2600(18)30452-1DOI Listing
January 2019

Non-invasive ventilation in acute respiratory failure of patients with obesity hypoventilation syndrome.

Minerva Med 2018 Dec;109(6 Suppl 1):1-5

Unit of Respiratory Diseases and Allergies, Department of Internal Medicine (DiMI), San Martino University Hospital, Genoa, Italy.

Introduction: Non-invasive ventilation (NIV) has been used successfully for the management of acute respiratory failure (ARF) more often in the last two decades compared to prior decades. There are particular groups of patients that are more likely to benefit from NIV. One of these groups is patients with obesity hypoventilation syndrome (OHS). Read More

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http://dx.doi.org/10.23736/S0026-4806.18.05921-9DOI Listing
December 2018

Dynamics of topsoil carbon stocks after prescribed burning for pasture restoration in shrublands of the Central Pyrenees (NE-Spain).

J Environ Manage 2019 Jan 8;233:695-705. Epub 2019 Jan 8.

Departamento de Ciencias Agrarias y del Medio Natural, Escuela Politécnica Superior de Huesca, Instituto de Investigación en Ciencias Ambientales (IUCA), Universidad de Zaragoza, Ctra Cuarte s/n, 22071, Huesca, Spain.

Prescribed burning has been recently readopted as a management practice in the Central Pyrenees (NE-Spain) to stop shrub encroachment processes and recover pasturelands. The immediate effects of prescribed burning on soil C stocks and related biological properties and their evolution in the short-to mid-term after burning were assessed. The study was conducted during three autumnal prescribed burnings in the Central Pyrenees in the municipalities of Buisán, Asín de Broto and Yebra de Basa. Read More

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http://dx.doi.org/10.1016/j.jenvman.2018.12.057DOI Listing
January 2019

Poisoning with malicious or criminal intent: characteristics and outcome of patients presenting for emergency care.

Clin Toxicol (Phila) 2019 Jan 14:1-4. Epub 2019 Jan 14.

a Division of Pediatric Emergency Medicine , Hospital for Sick Children , Toronto , ON , Canada.

Background: Poisoning is the leading cause of injury-related death in the USA. Poisoning with malicious or criminal intent is uncommon, and poorly characterized.

Objectives: To explore substances, patients' demographics, clinical presentation, management and outcome in victims of malicious poisoning in the USA. Read More

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https://www.tandfonline.com/doi/full/10.1080/15563650.2018.1
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http://dx.doi.org/10.1080/15563650.2018.1546009DOI Listing
January 2019
1 Read

Transnasal Humidified Rapid-Insufflation Ventilatory Exchange for Deep Sedation in a Lung Transplant Candidate With Severe Cystic Fibrosis: A Case Report.

A A Pract 2019 Jan 10. Epub 2019 Jan 10.

From the Department of Anesthesia, Mt. Sinai Hospital-Sinai Health System, University of Toronto, Toronto, Ontario, Canada.

Transnasal humidified rapid-insufflation ventilatory exchange is a recently described technique for safer management of difficult airways and a novel ventilation technique under anesthesia. Its full potential in patient safety and benefits are still being investigated. We describe the use of transnasal humidified rapid-insufflation ventilatory exchange for deep sedation during dental extractions in a patient with severe cystic fibrosis as a precondition for lung transplantation. Read More

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http://dx.doi.org/10.1213/XAA.0000000000000964DOI Listing
January 2019
1 Read

An Individualized, Interactive Intervention Promotes Terminally Ill Cancer Patients' Prognostic Awareness and Reduces Cardiopulmonary Resuscitation Received in the Last Month of Life: Secondary Analysis of a Randomized Clinical Trial.

J Pain Symptom Manage 2019 Jan 9. Epub 2019 Jan 9.

School of Nursing, Medical College, Chang Gung University, Department of Nursing, Chang Gung Memorial Hospital at Kaohsiung, and Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, Taiwan, 333, R.O.C. Electronic address:

Context/objective: Half of advanced cancer patients do not have accurate prognostic awareness (PA). However, few randomized clinical trials (RCTs) have focused on facilitating patients' PA to reduce their life-sustaining treatments (LSTs) at end of life (EOL). To address these issues, we conducted a double-blinded RCT on terminally ill cancer patients. Read More

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http://dx.doi.org/10.1016/j.jpainsymman.2019.01.002DOI Listing
January 2019

The clinical management of neuromuscular disorders in intensive care.

Neuromuscul Disord 2018 Dec 18. Epub 2018 Dec 18.

Neurology Division of Critical Care Neurology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Life-threatening neuromuscular disorders affect a small, but growing group of patients in the intensive care unit who present special management problems, as well as great therapeutic opportunities. In inflammatory conditions, a cure is often possible, and for chronic, genetic or degenerative conditions, achieving the previous level of function is the target. Neuromuscular experts and intensivists need to cooperate closely to achieve the best possible outcomes. Read More

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http://dx.doi.org/10.1016/j.nmd.2018.12.005DOI Listing
December 2018

The ketogenic diet for super-refractory status epilepticus patients in intensive care units.

Brain Dev 2019 Jan 9. Epub 2019 Jan 9.

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea. Electronic address:

Objectives: Super-refractory status epilepticus (SRSE) is one of the most challenging issues in intensive care units (ICUs) in that it is associated with high morbidity and mortality. Although the ketogenic diet (KD) has been reported to be effective in treating of SRSE, the use of the diet as therapy can be complicated by concomitant medical problems specific to critically ill patients. In this study, we aimed to describe our experience of the KD for SRSE patients in ICUs. Read More

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http://dx.doi.org/10.1016/j.braindev.2018.12.007DOI Listing
January 2019

Infant burns: A single institution retrospective review.

Burns 2019 Jan 8. Epub 2019 Jan 8.

Department of Paediatric Surgery, Red Cross War Memorial Children's Hospital and Faculty of Health Sciences, University of Cape Town, South Africa.

Thermal injuries amongst infants are common and a cause of significant mortality and morbidity in South Africa. This has been attributed to the lack of an enabling environment (poverty-related lack of safe living conditions) and the cognitive and physical developmental immaturity of infants, who depend on their surroundings and adults to keep them safe. This is a retrospective observational study of 548 infant admissions over 48 months. Read More

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http://dx.doi.org/10.1016/j.burns.2018.11.005DOI Listing
January 2019

Influence of storage environment on maize grain: CO production, dry matter losses and aflatoxins contamination.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2019 Jan 14:1-11. Epub 2019 Jan 14.

a Applied Mycology Group, Environment and AgriFood Theme , Cranfield University , Cranfield , UK.

Poor storage of cereals, such as maize can lead to both nutritional losses and mycotoxin contamination. The aim of this study was to examine the respiration of maize either naturally contaminated or inoculated with Aspergillus flavus to examine whether this might be an early and sensitive indicator of aflatoxin (AF) contamination and relative storability risk. We thus examined the relationship between different interacting storage environmental conditions (0. Read More

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http://dx.doi.org/10.1080/19440049.2018.1556403DOI Listing
January 2019

[The tracheo-team in the management of intracranic pressure during a dilatative tracheostomy in severe head trauma: the impact of a checklist].

Assist Inferm Ric 2018 Oct-Dec;37(4):189-195

. The tracheo-team in the management of intracranic pressure during a dilatative tracheostomy in severe head trauma: the impact of a checklist.

Introduction: Percutaneous dilatative tracheostomy (PDT) is a common technique in neurosurgical intensive care. Read More

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http://dx.doi.org/10.1702/3080.30723DOI Listing
January 2019

Clinical Characteristics and Antibiotic Resistance of Mycoplasma Pneumoniae Pneumonia in Hospitalized Chinese Children.

Comb Chem High Throughput Screen 2019 Jan 10. Epub 2019 Jan 10.

Department of Respiration, The First Hospital of Huzhou, First Affiliated Hospital of Huzhou University, No. 158 Guangchanghou Road, Huzhou, Zhejiang, 313000. China.

Aim To analyze the clinical characteristics and antibiotic resistance of Mycoplasma pneumoniae pneumonia (MP) in Chinese patients, providing valuable information for the management of patients with MP. Methods A total of 120 children who were hospitalized in The First Hospital of Huzhou between January and December 2016 for respiratory tract infection due to M. pneumoniae were enrolled in this study. Read More

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http://dx.doi.org/10.2174/1386207322666190111112946DOI Listing
January 2019
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Congenital diaphragmatic hernia sacs: prenatal imaging and associated postnatal outcomes.

Pediatr Radiol 2019 Jan 11. Epub 2019 Jan 11.

Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Background: The presence of a hernia sac in congenital diaphragmatic hernia (CDH) has been reported to be associated with higher lung volumes and better postnatal outcomes.

Objective: To compare prenatal imaging (ultrasound and MRI) prognostic measurements and postnatal outcomes of CDH with and without hernia sac.

Materials And Methods: We performed database searches from January 2008 to March 2017 for surgically proven cases of CDH with and without hernia sac. Read More

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http://dx.doi.org/10.1007/s00247-018-04334-9DOI Listing
January 2019

Evaluations of Morphine and Fentanyl for Mechanically Ventilated Patients With Respiratory Disorders in Intensive Care: A Systematic Review of Methodological Trends and Reporting Quality.

Value Health Reg Issues 2019 Jan 8;19:7-25. Epub 2019 Jan 8.

College of Pharmacy, Qatar University, Doha, Qatar. Electronic address:

Background: Mechanically ventilated patients with respiratory disorders may require sedatives, such as opioids.

Objectives: To define methodological trends, gaps, and the reporting quality of the comparative clinical and economic evaluations of fentanyl and morphine in ventilated patients in the intensive care unit.

Methods: We conducted a literature review of the MEDLINE, Embase, OVID, ScienceDirect, Springer Link, and EconLit databases, comparing studies in the management of ventilated patients with respiratory disorders in the intensive care unit using either fentanyl or morphine, or both. Read More

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http://dx.doi.org/10.1016/j.vhri.2018.11.001DOI Listing
January 2019

On-table extubation in neonates undergoing anoplasty: an experience of anesthetic management on the concept of fast-tracking anesthesia: A pilot study.

Medicine (Baltimore) 2019 Jan;98(2):e14098

Department of Anesthesiology, Sichuan University West China Hospital.

Fast-track anesthesia (FTA) is difficult to achieve in neonates due to immature organ function and high rates of perioperative events. As a high-risk population, neonates require prolonged postoperative mechanical ventilation, which may lead to contradictions in cases where neonatal intensive care unit resources and ventilator facilities are limited. The choice of anesthesia strategy and anesthetic can help achieve rapid postoperative rehabilitation and save hospitalization costs. Read More

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http://dx.doi.org/10.1097/MD.0000000000014098DOI Listing
January 2019
1 Read

Outcome Of Use Of Nasal Continuous Positive Airway Pressure Through Infant Flow Drivers In Neonates With Respiratory Distress In A Tertiary Care Hospital In Pakistan.

J Ayub Med Coll Abbottabad 2018 Oct-Dec;30(4):511-555

Iqbal Memorial Teaching Hospital/Khawaja Muhammad Safdar Medical College Sialkot, Pakistan.

Background: Nasal continuous positive pressure has been used for management of respiratory distress in neonates in various conditions as a primary modality. Objective of the study is to evaluate the frequency of improved outcome and complications of use of nasal CPAP through infant flow drivers in neonates with respiratory distress. The study was conducted from 2nd April 2017 to 2nd October 2017 in neonatal intensive care unit of Allama Iqbal Memorial Teaching Hospital Sialkot. Read More

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January 2019
1 Read

Laryngeal mask versus intubation for adenoidectomies in children: Analysis of 1,500 operations.

Laryngoscope 2019 Jan 10. Epub 2019 Jan 10.

Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital Würzburg, Würzburg, Germany.

Objectives/hypothesis: To evaluate whether endotracheal intubations are superior to the use of laryngeal masks in the airway management for adenoidectomies in pediatric patients in terms of safety and duration of surgery.

Study Design: Retrospective case series.

Methods: A retrospective analysis of 1,500 adenoidectomies in children using laryngeal mask or endotracheal intubation for intraoperative ventilation between 2009 and 2017. Read More

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http://doi.wiley.com/10.1002/lary.27794
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http://dx.doi.org/10.1002/lary.27794DOI Listing
January 2019
1 Read

Airway pressure release ventilation versus conventional ventilation for the management of pediatric acute respiratory distress syndrome: do we have an answer?

J Thorac Dis 2018 Nov;10(Suppl 33):S4085-S4087

Division of Pediatric Critical Care, Department of Pediatrics, Case Western Reserve University School of Medicine, Metro Health Medical Center, Cleveland, OH, USA.

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http://jtd.amegroups.com/article/view/24655/19018
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http://dx.doi.org/10.21037/jtd.2018.10.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297477PMC
November 2018
1 Read

Conservative Fluid Management After Sepsis Resuscitation: A Pilot Randomized Trial.

J Intensive Care Med 2019 Jan 10:885066618823183. Epub 2019 Jan 10.

1 Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.

Rationale:: The feasibility and clinical outcomes of conservative fluid management after sepsis resuscitation remain unknown.

Objectives:: To evaluate the effect of a conservative fluid management protocol on fluid balance and intensive care unit (ICU)-free days among patients with sepsis.

Methods:: In a single-center phase II/III randomized trial, we enrolled adults with suspected infection, ≥2 systemic inflammatory response syndrome criteria, and either shock (mean arterial pressure <60 mm Hg or vasopressors) or respiratory insufficiency (mechanical ventilation or oxygen saturation <97% and fraction of inspired oxygen ≥0. Read More

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http://dx.doi.org/10.1177/0885066618823183DOI Listing
January 2019

Ventilatory support after extubation in critically ill patients.

Lancet Respir Med 2018 Dec;6(12):948-962

University Department of Medical, Oral and Biotechnological Sciences, Gabriele d'Annunzio University of Chieti-Pescara, Chieti, Italy; Clinical Department of Anaesthesiology and Intensive Care Medicine, SS. Annunziata Hospital, Chieti, Italy.

The periextubation period represents a crucial moment in the management of critically ill patients. Extubation failure, defined as the need for reintubation within 2-7 days after a planned extubation, is associated with prolonged mechanical ventilation, increased incidence of ventilator-associated pneumonia, longer intensive care unit and hospital stays, and increased mortality. Conventional oxygen therapy is commonly used after extubation. Read More

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http://dx.doi.org/10.1016/S2213-2600(18)30375-8DOI Listing
December 2018

Beyond the guidelines for non-invasive ventilation in acute respiratory failure: implications for practice.

Lancet Respir Med 2018 Dec;6(12):935-947

Department of Respiratory Medicine, St James' University Hospital, Leeds, UK. Electronic address:

Non-invasive ventilation is standard therapy in the management of both hypoxaemic and hypercapnic respiratory failure of various causes. The evidence base for its use and when and how it should be used has been reviewed in two recent guidelines. In this Series paper, we look beyond the guidelines to what is happening in everyday clinical practice in the real world, how patient selection can be refined to maximise the chances of a successful outcome, and emerging alternative therapies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22132600183038
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http://dx.doi.org/10.1016/S2213-2600(18)30388-6DOI Listing
December 2018
1 Read

The bioimpedance spectroscopy as useful tool for measuring the fluid excess and fluid management in severe polytrauma patients.

Physiol Res 2019 Jan 10. Epub 2019 Jan 10.

Faculty of Pharmacy, Educational and Research Center of Charles University, Hradec Kralove, Czech Republic.

Although the fluid therapy plays a fundamental role in the management of polytrauma patients (PP), a tool which could determine it appropriately is still lacking. The aim of this study was to evaluate the application of a bioimpedance spectroscopy (BIS) for body fluids volume and distribution monitoring in these patients. This prospective, observational study was performed on 25 severe PP and 25 healthy subjects. Read More

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January 2019

Modern life makes children allergic. A cross-sectional study: associations of home environment and lifestyles with asthma and allergy among children in Tianjin region, China.

Int Arch Occup Environ Health 2019 Jan 9. Epub 2019 Jan 9.

Tianjin Key Laboratory of Indoor Air Environmental Quality Control, School of Environmental Science and Engineering, Tianjin University, Tianjin, 300350, China.

Purpose: In the past 60 years, the prevalences of asthma and allergy among children have increased around the world. Neither genetic nor outdoor environmental factors can explain this increase.

Methods: We performed a cross-sectional study of 7366 children in Tianjin, China, on associations of home environment and lifestyles with asthma and allergy. Read More

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http://link.springer.com/10.1007/s00420-018-1395-3
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http://dx.doi.org/10.1007/s00420-018-1395-3DOI Listing
January 2019
3 Reads

Weaning failure of cardiovascular origin: how to suspect, detect and treat-a review of the literature.

Ann Intensive Care 2019 Jan 9;9(1). Epub 2019 Jan 9.

First Department of Critical Care, Medical School, National and Kapodistrian University of Athens, "Evangelismos" Hospital, Ipsilantou 45-47, 10676, Athens, Greece.

Among the multiple causes of weaning failure from mechanical ventilation, cardiovascular dysfunction is increasingly recognized as a quite frequent cause that can be treated successfully. In this review, we summarize the contemporary evidence of the most important clinical and diagnostic aspects of weaning failure of cardiovascular origin with special focus on treatment. Pathophysiological mechanisms are complex and mainly include increase in right and left ventricular preload and afterload and potentially induce myocardial ischemia. Read More

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http://dx.doi.org/10.1186/s13613-019-0481-3DOI Listing
January 2019

In-vehicle airborne fine and ultra-fine particulate matter exposure: The impact of leading vehicle emissions.

Environ Int 2019 Feb 5;123:407-416. Epub 2019 Jan 5.

Department of Science and High Technology, Università degli Studi dell'Insubria, via Valleggio 11, 22100 Como, Italy.

Airborne particulate matter (PM) concentrations inside vehicle cabins are often extremely high compared to background levels. The present study was motivated by the fact that in the last few decades, the implementation of new emission standards has led to the reduction of vehicle particle emissions. This study addresses for the first time the relationship between leading vehicle (LV) emissions and in-cabin PM exposure levels in the immediately following vehicle (henceforth called the study vehicle - SV), with particular emphasis on the role of the LV's emission reduction technologies (e. Read More

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http://dx.doi.org/10.1016/j.envint.2018.12.020DOI Listing
February 2019

Perfusion Scintigraphy in Diagnosis and Management of Thromboembolic Pulmonary Hypertension.

Radiographics 2019 Jan-Feb;39(1):169-185

From the Department of Radiology, Division of Nuclear Medicine (F.M., C.K.H.); and Division of Pulmonary, Critical Care, and Sleep Medicine (T.A.M.), University of California, San Diego, San Diego, Calif.

Chronic thromboembolic pulmonary hypertension (CTEPH) is a life-threatening complication of acute pulmonary embolism (PE). Because the treatment of CTEPH is markedly different from that of other types of pulmonary hypertension, lung ventilation-perfusion (V/Q) scintigraphy is recommended for the workup of patients with unexplained pulmonary hypertension. Lung V/Q scintigraphy is superior to CT pulmonary angiography for detecting CTEPH. Read More

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http://dx.doi.org/10.1148/rg.2019180074DOI Listing
January 2019
2 Reads

Enteral versus intravenous approach for the sedation of critically ill patients: a randomized and controlled trial.

Crit Care 2019 Jan 7;23(1). Epub 2019 Jan 7.

Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, A.O. San Paolo - Polo Universitario, Via A. Di Rudinì, 8, 20142, Milano, Italy.

Background: ICU patients must be kept conscious, calm, and cooperative even during the critical phases of illness. Enteral administration of sedative drugs might avoid over sedation, and would be as adequate as intravenous administration in patients who are awake, with fewer side effects and lower costs. This study compares two sedation strategies, for early achievement and maintenance of the target light sedation. Read More

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http://dx.doi.org/10.1186/s13054-018-2280-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323792PMC
January 2019

Extracorporeal Carbon Dioxide Removal in the Management of Complex Bilateral Flail Chest Injury.

ASAIO J 2019 Jan 3. Epub 2019 Jan 3.

From the Division of Critical Care Medicine, Department of Medicine, Louisiana State University Health Sciences Center, Shreveport, Louisiana.

Flail chest is an uncommon consequence of traumatic injury. Medical management includes mechanical ventilation for internal pneumatic stabilization. Control of respiratory drive is necessary to avoid paradoxical movement and impairment of recovery. Read More

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http://dx.doi.org/10.1097/MAT.0000000000000942DOI Listing
January 2019
1.385 Impact Factor

Plant diversity loss reduces soil respiration across terrestrial ecosystems.

Glob Chang Biol 2019 Jan 6. Epub 2019 Jan 6.

Faculty of Natural Resources Management, Lakehead University, 955 Oliver Road, Thunder Bay, ON, P7B 5E1, Canada.

The rapid global biodiversity loss has led to the declines in ecosystem function. Despite the critical importance of soil respiration in the global carbon and nutrient cycles, how plant diversity loss affects Rs remains uncertain. Here we present a meta-analysis using 446 paired observations from 95 published studies to evaluate the effects of plant and litter mixtures on soil respiration and its components. Read More

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http://doi.wiley.com/10.1111/gcb.14567
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http://dx.doi.org/10.1111/gcb.14567DOI Listing
January 2019
8 Reads

Awareness and management of pulmonary embolism among physicians in China: a nationwide cross-sectional study.

J Thromb Thrombolysis 2019 Jan 5. Epub 2019 Jan 5.

Department of Respiratory Disease, Capital Medical University, 2 Yinghua Dongjie, Hepingli, Chaoyang District, Beijing, 100029, China.

Pulmonary embolism (PE) is a leading cause of cardiovascular mortality. We intended to evaluate the awareness and management status of PE among Chinese physicians and provide the basis for establishing Chinese clinical guidelines on PE. We designed a nationwide survey to collect data on physicians' awareness of diagnosis, treatment and follow-up on PE. Read More

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http://dx.doi.org/10.1007/s11239-018-1788-xDOI Listing
January 2019

Does Lung Compliance Optimization Through PEEP Manipulations Reduce the Incidence of Postoperative Hypoxemia in Laparoscopic Bariatric Surgery? A Randomized Trial.

Obes Surg 2019 Jan 5. Epub 2019 Jan 5.

Department of Anaesthesiology, CHU Brugmann-HUDERF, Université Libre de Bruxelles, 1090, Brussels, Belgium.

Background: In obese patients (OP), the best intraoperative ventilation strategy remains to be defined. Dynamic lung compliance (C) and dead space fraction are indicators of efficient ventilation at an optimal positive end-expiratory pressure (PEEP). Herein, we investigated whether intraoperative dynamic lung compliance optimization through PEEP manipulations affects the incidence of postoperative hypoxemia (SpO < 90%) in OP undergoing laparoscopic bariatric surgery (LBS). Read More

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http://dx.doi.org/10.1007/s11695-018-03662-xDOI Listing
January 2019
1 Read

In vivo detection of endotracheal tube biofilms in intubated critical care patients using catheter-based optical coherence tomography.

J Biophotonics 2019 Jan 2:e201800307. Epub 2019 Jan 2.

Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.

The formation of biofilms in the endotracheal tubes (ETTs) of intubated patients on mechanical ventilation is associated with a greater risk of ventilator-associated pneumonia (VAP) and death. New technologies are needed to detect and monitor ETTs in vivo for the presence of these biofilms. Longitudinal OCT imaging was performed in mechanically ventilated subjects at 24 hr intervals until extubation to detect the formation and temporal changes of in vivo ETT biofilms. Read More

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http://dx.doi.org/10.1002/jbio.201800307DOI Listing
January 2019

Effects of thyroid hormones and cold acclimation on the energy metabolism of the striped hamster (Cricetulus barabensis).

J Comp Physiol B 2019 Feb 2;189(1):153-165. Epub 2019 Jan 2.

College of Life and Environmental Science, Wenzhou University, Wenzhou, 325035, Zhejiang, People's Republic of China.

To examine the effects of low ambient temperature and thyroid hormones on the energy metabolism of the striped hamster (Cricetulus barabensis), adult male striped hamsters were kept at 30 °C, or acclimated to 5 °C, for 4 weeks. During this time, hamsters were treated with a synthetic thyroxine, levothyroxine sodium (LTS), the antithyroid drug methimazole, or saline solution (control). Hamster's food intake, basal metabolic rate (BMR), non-shivering thermogenesis (NST), thyroid hormones, body fat content, mitochondrial state-4 respiration, cytochrome c oxidase, and uncoupling protein 1 (UCP1) gene expression in brown adipose tissue (BAT), were measured. Read More

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http://dx.doi.org/10.1007/s00360-018-1197-7DOI Listing
February 2019

[Breve reseña histórica de la primera publicación del síndrome de insuficiencia respiratoria aguda].

Cir Cir 2019 ;87(1):113-122

Instituto Nacional de Ciencias Médicas y Nutrición Dr. Salvador Zubirán, Ciudad de México, México.

Acute respiratory distress syndrome was first described by Ashbaugh, Petty, Levine y Bigellow in 1967 writing in The Lancet. Their study was based on a case series of 12 patients with acute respiratory distress, cyanosis refractory to oxygen therapy, decreased lung compliance and diffuse infiltrates evident on the chest radiograph. Mortality was 58% with greater survival in five patients managed with mechanical ventilation and positive end expiratory pressure. Read More

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http://dx.doi.org/10.24875/CIRU.18000592DOI Listing
January 2019

Continuous caudal epidural analgesia and early feeding in delayed bladder exstrophy repair: a nine-year experience.

J Pediatr Urol 2018 Nov 3. Epub 2018 Nov 3.

Department of Pediatric Anaesthesia, Royal Manchester Children's Hospital, Oxford Road, Manchester, M13 9WL, UK. Electronic address:

Background: Children undergoing primary closure of bladder exstrophy experience blood loss and significant fluid shifts and require protracted periods of postoperative immobilization to avoid compromising the repair. Suboptimal anxiolysis and pain management is associated with increased morbidity. There is a lack of consensus on the optimal analgesic technique and studies have not previously described analgesic management in delayed bladder exstrophy closure. Read More

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http://dx.doi.org/10.1016/j.jpurol.2018.10.022DOI Listing
November 2018

The Effectiveness of Noninvasive Positive Pressure Ventilation in Subarachnoid Pleural Fistula: A Case Report and Literature Review.

Neurospine 2018 Dec 2;15(4):394-399. Epub 2018 Oct 2.

Department of Spine Surgery, Ganga Hospital, Coimbatore, India.

Subarachnoid pleural fistula (SPF) is an aberrant communication between the pleural cavity and subarachnoid space, resulting in uncontrolled cerebrospinal fluid drainage. The negative pressure of the pleural cavity creates a continuous suctioning effect, thereby impeding the spontaneous closure of these fistulas. Dural tears or punctures in cardiothoracic procedures, spinal operations, and trauma are known to cause such abnormal communications. Read More

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http://dx.doi.org/10.14245/ns.1836056.028DOI Listing
December 2018
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Acclimation and adaptation components of the temperature dependence of plant photosynthesis at the global scale.

New Phytol 2018 Dec 29. Epub 2018 Dec 29.

Department of Biology, The University of Western Ontario, London, ON, Canada, N6A 5B6.

The temperature response of photosynthesis is one of the key factors determining predicted responses to warming in global vegetation models (GVMs). The response may vary geographically, due to genetic adaptation to climate, and temporally, due to acclimation to changes in ambient temperature. Our goal was to develop a robust quantitative global model representing acclimation and adaptation of photosynthetic temperature responses. Read More

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http://doi.wiley.com/10.1111/nph.15668
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http://dx.doi.org/10.1111/nph.15668DOI Listing
December 2018
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Intensive care unit complications and outcomes of adult patients with hemophagocytic lymphohistiocytosis: A retrospective study of 16 cases.

World J Crit Care Med 2018 Nov 30;7(6):73-83. Epub 2018 Nov 30.

Department of Pulmonary, Critical Care and Sleep, Baylor College of Medicine, Houston, TX 77030, United States.

Aim: To study the management, complications and outcomes of adult patients admitted with hemophagocytic lymphohistiocytosis (HLH) in the intensive care unit (ICU).

Methods: We performed a retrospective observational study of adult patients with the diagnosis of "HLH" admitted to the two academic medical ICUs of Baylor College of Medicine between 01/01/2013 to 06/30/2017. HLH was diagnosed using the HLH-2004 criteria proposed by the Histiocyte Society. Read More

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http://dx.doi.org/10.5492/wjccm.v7.i6.73DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305525PMC
November 2018
1 Read

The Right Ventricle During Selective Lung Ventilation for Thoracic Surgery.

J Cardiothorac Vasc Anesth 2018 Nov 22. Epub 2018 Nov 22.

University Hospitals Birmingham National Health Service Foundation Trust, Department of Critical Care Medicine, Queen Elizabeth Hospital Birmingham, Edgbaston, Birmingham, UK; Birmingham Acute Care Research Group, Institute of Inflammation and Ageing, Centre of Translational Inflammation Research, University of Birmingham, Birmingham, UK.

The right ventricle (RV) has been an area of evolving interest after decades of being ignored and considered less important than the left ventricle. Right ventricular dysfunction/failure is an independent predictor of mortality and morbidity in cardiac surgery; however, very little is known about the incidence or impact of RV dysfunction/failure in thoracic surgery. The pathophysiology of RV dysfunction/failure has been studied in the context of acute respiratory distress syndrome (ARDS), cardiac surgery, pulmonary hypertension, and left ventricular failure, but limited data exist in literature addressing the issue of RV dysfunction/failure in the context of thoracic surgery and one-lung ventilation (OLV). Read More

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http://dx.doi.org/10.1053/j.jvca.2018.11.030DOI Listing
November 2018
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Conium maculatum intoxication: Literature review and case report on hemlock poisoning.

Forensic Sci Rev 2019 Jan;31(1):23-36

Laboratory of Forensic Sciences, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.

The aim of this paper is to highlight the symptomatology in three Conium maculatum intoxication incidents, one of which was fatal. A number of studies were reviewed in order to update and summarize the relevant literature on the incidence, sociodemographic variables, method of poisoning, pathophysiology, diagnosis, variables associated with survival and fatality, management, and treatment of C. maculatum intoxication as well as the biosynthesis and biological effects of poison hemlock alkaloids. Read More

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January 2019
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A real life evaluation of non invasive ventilation in acute cardiogenic pulmonary edema: a multicenter, perspective, observational study for the ACPE SIMEU study group.

BMC Emerg Med 2018 Dec 29;18(1):61. Epub 2018 Dec 29.

Emergency Medicine Department, ASST Papa Giovanni XIII, Bergamo, Italy.

Background: During the past three decades conflicting evidences have been published on the use of non-invasive ventilation (NIV) in patients with acute cardiogenic pulmonary edema (ACPE). The aim of this study is to describe the management of acute respiratory failure (ARF) due to ACPE in twelve Italian emergency departments (EDs). We evaluated prevalence, characteristics and outcomes of ACPE patients treated with oxygen therapy, continuous positive airway pressure (CPAP) or Bi-level positive airway pressure (BiPAP) on admission to the EDs. Read More

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http://dx.doi.org/10.1186/s12873-018-0216-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310941PMC
December 2018
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[Effect of enteral nutrition tolerance assessment standardized process management on ventilator associated pneumonia and prognosis in patients with tracheotomy and long-term mechanical ventilation in intensive care unit].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Dec;30(12):1173-1177

Department of Cardiothoracic Surgery, Changzhou First People's Hospital, Changzhou 213003, Jiangsu, China. Corresponding author: Wang Bin, Email:

Objective: To investigate the effect of enteral nutrition (EN) tolerance assessment standardized process management on nosocomial infection and prognosis in patients with tracheotomy and long-term mechanical ventilation (MV) in intensive care unit (ICU).

Methods: A prospective cohort study was conducted. Forty-six patients who required long-term MV due to tracheotomy admitted to ICU of Changzhou First People's Hospital from January 2015 to December 2017 were enrolled. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2018.012.014DOI Listing
December 2018
1 Read