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    Success rate and factors predictive of redo radiofrequency ablation of perforator veins.
    J Vasc Surg Venous Lymphat Disord 2018 Apr 17. Epub 2018 Apr 17.
    Department of Vascular Surgery, Vascular Institute of New York, Brooklyn, NY.
    Objective: Radiofrequency ablation (RFA) is increasingly being employed for treatment of perforator vein insufficiency and venous ulcer healing. Previous studies have shown a closure rate of 60% to 80% in incompetent perforator veins (IPVs) with RFA. The purpose of the study was to determine the utility of a redo RFA for symptomatic recanalized perforators and to predict factors associated with recanalization. Read More

    Saphenous vein ablation with a new cyanoacrylate glue device: a systematic review on 1000 cases.
    Minim Invasive Ther Allied Technol 2018 Apr 19:1-9. Epub 2018 Apr 19.
    b Vascular Surgery Department , ASST Fatebenefratelli-Sacco , Milan , Italy.
    Background: To review published evidence regarding an n-butyl-cyanoacrylate (NBCA) injection device for great (GSV) and small (SSV) saphenous vein incompetence in terms of occlusion rate, postoperative complications and quality of life improvement.

    Material And Methods: International bibliographic databases (PubMed, EMBASE, Scopus) were searched to identify possible target articles. The only inclusion criterion was the use of the Variclose system (Biolas, Ankara, Turkey) for superficial vein insufficiency. Read More

    [Conservative management of varicosis and postthrombotic syndrome].
    Hautarzt 2018 Apr 17. Epub 2018 Apr 17.
    Klinik für Dermatologie der Ruhr-Universität Bochum, Venenzentrum der Dermatologischen und Gefäßchirurgischen Kliniken der Ruhr-Universität Bochum im St. Maria-Hilf-Krankenhaus, Ruhr-Universität Bochum, Hiltroper Landwehr 11-13, 44805, Bochum, Deutschland.
    Both varicosis and postthrombotic syndrome are manifestations of chronic venous disease - a widespread disease. Even at an early stage there are visible vascular symptoms, feeling of heaviness and tendency to swelling. In advanced stages, skin alterations and chronic wounds follow. Read More

    The effect of commercial insurance policies on outcomes of venous ablation.
    J Vasc Surg Venous Lymphat Disord 2018 May;6(3):331-337.e1
    Section of Vascular Surgery, Department of Surgery, Yale University School of Medicine, New Haven, Conn.
    Objective: The use of venous ablation (VA) for treatment of chronic venous insufficiency has exponentially increased. To limit cost and overuse, insurance companies have adopted aleatory policies. The goal of this study was to compare the policies of five major local insurance carriers and to determine whether treatment within the criteria of a certain policy is associated with improved patient outcomes. Read More

    Ecchymosis: A novel sign in patients with varicose veins.
    Clin Hemorheol Microcirc 2018 ;68(4):413-419
    Department of Cardiovascular Medicine, Division of Cardiology, Munster University Hospital, Munster, Germany.
    Background: In the absence of trauma, hematologic disease and anti-platelet use, no attention has been paid to elucidate the mechanism of ecchymosis. It has taken our attention that ecchymosis on lower limb might be a sign of varicose vein. Accordingly, we aimed to analyze and describe the frequency of leg symptoms and presence of ecchymosis in patients with varicose vein. Read More

    Medical compression stockings reduce hypertension of nailfold capillaries at the toe of patients with chronic venous insufficiency1.
    Clin Hemorheol Microcirc 2018 Apr 7. Epub 2018 Apr 7.
    University Dermatology Clinic, University-Medicine, Greifswald, Germany.
    In five patients who suffered from chronic venous insufficiency clinical stage C4 (n = 3) and C6 (n = 2) the capillary blood pressure was measured twice by means of invasive direct cannulation of nailfold capillaries of the toe. During one measurement course the patients wore below knee medical compression stockings (40 mmHg) during the other they did not have compression therapy. With the patient in supine position, the CP was investigated by the servo-nulling technique under resting conditions and under dynamic conditions: the calf-muscle/ankle joint venous pump was simulated by means of inflating a blood pressure cuff, which surrounded the mid lower leg, to 60 mmHg for 60 s. Read More

    Chronic iliofemoral vein obstruction - an under-recognized cause of exercise limitation.
    Eur J Sport Sci 2018 Apr 13:1-7. Epub 2018 Apr 13.
    a Pulmonary Institute, Sheba Medical Center , Ramat Gan , Israel.
    Local symptoms of chronic venous insufficiency after deep vein thrombosis (DVT) are well described, but little is known about the effect of residual venous obstruction on exercise capacity. We tested our hypothesis that chronic residual iliofemoral vein occlusion (IFVO) after DVT may impair exercise capacity. Nine post-DVT patients with residual IFVO and effort intolerance were studied; a comparison cohort consisted of 11 healthy volunteers. Read More

    Asymptomatic Deep Vein Thrombosis During Free Flap: Concerns in Free Flap Surgery.
    Plast Reconstr Surg 2018 Mar 30. Epub 2018 Mar 30.
    Department of Plastic and Reconstructive Surgery, School of Medicine, Ewha Womans University, Seoul, Korea.
    Background: Venous insufficiency is the most frequent cause of failure in free flap reconstruction of the lower extremity. When deep vein thrombosis (DVT) is detected during preoperative assessment of the lower extremity, decisions regarding treatment plans become difficult, and no relevant guidelines regarding surgery and preoperative treatment of patients with DVT who need a free flap transfer are currently available.

    Methods: In order to find a relevant guideline in decision-making regarding surgery and preoperative treatment of patients with DVT who require free flap reconstruction, a systematic literature review was conducted searching MEDLINE, PubMed Central, Cochrane, and Embase databases for articles published between 1996 and 2015. Read More

    Lower-limb Ulcers in Systemic Sclerosis: A Multicentre Retrospective Case-control Study.
    Acta Derm Venereol 2018 Apr 12. Epub 2018 Apr 12.
    Department of Dermatology, Tenon Hospital, Public Assistance - Paris Hospitals (AP-HP), Paris, France.
    Lower-limb ulcers in systemic sclerosis patients are rarely reported. The aim of this study was to describe the main causes and outcomes of lower-limb ulcers in systemic sclerosis patients and to assess factors associated with ischemic causes (arterial disease and/or microvascular impairment). A retrospective, multicentre, case-control study was conducted in 2013 and 2014, including 45 systemic sclerosis patients presenting lower-limb ulcers between 2008 and 2013. Read More

    A retrospective study of a new n-butyl-2-cyanoacrylate glue ablation catheter incorporated with application guiding light for the treatment of venous insufficiency: Twelve-month results.
    Vascular 2018 Jan 1:1708538118770548. Epub 2018 Jan 1.
    3 Batman Regional State Hospital, Batman, Turkey.
    Objective This study aims to present the early results of a retrospective study of the use of novel n-butyl-2-cyanoacrylate (VenaBlock)-based nontumescent endovenous ablation with a guiding light for the treatment of patients with varicose veins. Methods Patients with lower limb venous insufficiency were treated with n-butyl-2-cyanoacrylate (VenaBlock Venous Closure System) between April 2016 and July 2016. The study enrolled adults aged 21-70 years with symptomatic moderate to severe varicosities (C2-C4b) and great saphenous vein reflux lasting longer than 0. Read More

    Latest Innovations in the Treatment of Venous Disease.
    J Clin Med 2018 Apr 11;7(4). Epub 2018 Apr 11.
    Cardiovascular Medicine, Yale University, 789 Howard Avenue, New Haven, CT 06519, USA.
    Venous disease is more common than peripheral arterial disease. Pathophysiologically, venous disease can be associated with obstruction, reflux, or both. A common feature in chronic venous disease is ambulatory venous hypertension. Read More

    Experience of Using Shear Wave Elastography Imaging in Superficial Venous Insufficiency of the Lower Extremity.
    Ultrasound Q 2018 Apr 10. Epub 2018 Apr 10.
    We investigated the effectiveness of shear wave elastography (SWE) in patients with lower extremity superficial venous insufficiency (VI). A total of 138 symptomatic patients, 51 asymptomatic volunteers, and a total of 359 lower extremities (257 symptomatic, 102 asymptomatic) were examined. All participants underwent Doppler ultrasound (US) evaluation to determine VI and SWE measurements performed by manually drawing vein wall and perivenous tissue with free region of interest at the great saphenous vein (GSV) and small saphenous vein (SSV). Read More

    [Current view on the pathogenesis of varicocele and the problem of its recurrence].
    Urologiia 2018 Mar(1):150-154
    I.M. Sechenov First MSMU, Moscow, Russia.
    The clinical signs of varicocele typically emerge during the puberty. Varicocele is found in 15% of men in the general population and 25-35% and 50-80% of males presenting with primary and secondary infertility, respectively. Factors contributing to the development and recurrence of varicocele include the abnormalities of the testicular venous drainage and outflow (varicose veins are more common on the left than on the right), the anatomical features of the veins of the testicular and prostatic venous plexus, the patients constitution, predisposition to constipation or diarrhea, physical activity. Read More

    Varicose Veins and Lower Extremity Venous Insufficiency.
    Semin Intervent Radiol 2018 Mar 5;35(1):56-61. Epub 2018 Apr 5.
    Department of Radiology, University of Colorado, Aurora, Colorado.
    Lower extremity venous insufficiency and varicose veins are common conditions, affecting up to 25% of women. Herein, we review the pathophysiology of lower extremity venous insufficiency and varicose veins, the epidemiology of varicose veins, clinical diagnosis, and ultrasonographic diagnosis. We also discuss treatment rationale, algorithms, and techniques, with a focus on endovenous great saphenous vein ablation. Read More

    Pelvic Congestion Syndrome: Systematic Review of Treatment Success.
    Semin Intervent Radiol 2018 Mar 5;35(1):35-40. Epub 2018 Apr 5.
    Division of Vascular and Interventional Radiology, Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
    Pelvic venous insufficiency is now a well-characterized etiology of pelvic congestion syndrome (PCS). The prevalence of CPP is 15% in females aged 18 to 50 years in the United States and up to 43.4% worldwide. Read More

    Placentas from women with pregnancy-associated venous insufficiency show villi damage with evidence of hypoxic cellular stress.
    Hum Pathol 2018 Apr 4. Epub 2018 Apr 4.
    Department of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, University of Alcalá, Alcalá de Henares. Networking Biomedical Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Ramón y Cajal Institute of Sanitary Research (IRYCIS), Madrid, Spain.. Electronic address:
    Lower extremity venous insufficiency (VI) is a complication of pregnancy. The potential association of this venous disease with structural damage of the placenta has not been described. We analyzed the pattern of histopathological lesions and the gene and protein expression of HIF1-α and apoptosis regulatory proteins. Read More

    The Relationship Between Age and Chronic Kidney Disease in Patients Undergoing Pancreatic Resection.
    J Gastrointest Surg 2018 Apr 5. Epub 2018 Apr 5.
    Department of Medicine, Division of General Internal Medicine - Academic, University of Nebraska Medical Center, Omaha, NE, USA.
    Background: Severe chronic kidney disease (CKD) predicts adverse outcomes in patients undergoing pancreatectomy, but the impact of milder CKD is unknown. Additionally, some authors have suggested that, due to physiologic changes of aging, CKD is over-diagnosed in patients above age 65.

    Methods: Patients undergoing pancreatectomy for malignancy from 2005 to 2014 were identified from the National Surgical Quality Improvement Program. Read More

    Relationship between the von Willebrand Factor Plasma Concentration and Ultrasonographic Doppler Findings in Pregnancies Complicated by Hypertensive Disorders: A Pilot Study.
    Gynecol Obstet Invest 2018 Apr 5. Epub 2018 Apr 5.
    Department and Division of Perinatology and Gynecology, Poznan University of Medical Sciences, Poznan, Poland.
    Background/aims: Recent evidence suggests that impaired cytotrophoblast proliferation and migration are major factors responsible for the development of hypertension in pregnancy. Studies report that von Willebrand factor (vWf) is a specific endothelial damage plasma marker. The aim of this study was to evaluate the relationship between vWf maternal plasma concentration and maternal and fetal Doppler flow measurements in pregnancies complicated by hypertension. Read More

    Assessment of veins in T2*-weighted MR angiography predicts infarct growth in hyperacute ischemic stroke.
    PLoS One 2018 4;13(4):e0195554. Epub 2018 Apr 4.
    Department of Neurosurgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
    Background And Purpose: T2*-weighted magnetic resonance angiography (SWAN) detects hemodynamic insufficiency as hypointense areas in medullary or cortical veins. We therefore investigated whether SWAN can help predict ischemic penumbra-like lesions in patients with acute ischemic stroke (AIS).

    Materials And Methods: Magnetic resonance imaging (MRI) records-including SWAN, diffusion-weighted imaging (DWI), and magnetic resonance angiography (MRA)-of consecutive patients with major vessel occlusion within 6 h from AIS onset were analyzed. Read More

    Venous insufficiency: Differences in the content of trace elements. A preliminary report.
    Adv Clin Exp Med 2018 Apr 4. Epub 2018 Apr 4.
    Department of Experimental Surgery and Biomaterials Research, Wroclaw Medical University, Poland.
    Background: Venous insufficiency is still a serious clinical problem. The exact cause and molecular mechanisms of this disease are still unknown. In this study, we try to identify whether there is a difference in the level of trace elements between healthy and pathological veins. Read More

    The Use of Medicinal Leeches for the Treatment of Venous Congestion in Replanted or Revascularized Digits.
    J Hand Surg Am 2018 Mar 27. Epub 2018 Mar 27.
    Department of Hand Surgery, Sheba Medical Center, Affiliated to Sackler School of Medicine, Tel Aviv University, Ramat Gan, Israel.
    Purpose: A noteworthy cause of failure in digital replantation is venous insufficiency. External bloodletting with medicinal leeches is a common treatment for venous insufficiency after distal digital replantations. The objective of this study was to evaluate the salvage rate of digits replanted proximal to the distal interphalangeal (DIP) joint that were treated with medicinal leeches for venous congestion. Read More

    The Spectrum of Glomerulopathies in Kashmir: A Tertiary Care Experience.
    Nephron 2018 Mar 29. Epub 2018 Mar 29.
    Department of Internal Medicine, College of Medicine, Taif University, Taif, Saudi Arabia.
    Background: There is a paucity of data on the spectrum of renal diseases prevalent in the Jammu and Kashmir region.

    Objectives: To determine the spectrum of glomerulopathies in adult patients attending a tertiary care centre.

    Methods: Two hundred and twenty-one adequate biopsies from native kidneys of adult patients who presented with features suggestive of glomerular diseases at Sheri Kashmir Institute of medical sciences Srinagar Kashmir for the last 8 years were studied in a retrospective manner. Read More

    Clinical and Laboratory Profile of Zika and Dengue Infected Patients: Lessons Learned From the Co-circulation of Dengue, Zika and Chikungunya in Brazil.
    PLoS Curr 2018 Feb 15;10. Epub 2018 Feb 15.
    Medical Clinic Department, Federal University of Mato Grosso do Sul, Campo,Grande, MS, Brazil.
    Background: The current triple epidemic caused by dengue, zika and chikungunya constitutes a serious health problem in Brazil. The aim of this study was to investigate acute samples (up to the 7 days of symptoms) from patients presenting acute fever syndrome suspected as arboviral infection and characterize the clinical and laboratorial profile during the co-circulation of dengue, zika and chikungunya in Campo Grande, Mato Grosso do Sul (MS), midwest region of Brazil.

    Methods: All suspected cases (n=134) were tested by using serological and molecular diagnostic tests including DENV, ZIKV and CHIKV RT-PCR, Dengue nonstructural protein 1 (NS1) antigen capture ELISA, anti- DENV IgM ELISA and anti-CHIKV IgM ELISA. Read More

    The level of awareness and the attitude of patients recommended for use of compression stockings in Turkish society, and investigation of the factors affecting their use.
    Patient Prefer Adherence 2018 16;12:399-407. Epub 2018 Mar 16.
    Department of Business Administration, Cumhuriyet University Faculty of Economics and Administrative Sciences, Sivas, Turkey.
    Objective: The purpose of this study was to reveal the treatment outlook, usage habits, and factors affecting these habits, in addition to providing suggestions for solutions for patients who are frequently recommended the use of compression stockings as treatment for conditions such as chronic venous insufficiency, deep vein thrombosis, lymphedema, and pregnancy.

    Methods: The study was conducted as a face-to-face questionnaire session with 1,004 patients who had previously registered at the cardiovascular surgeon's polyclinic of Sivas Numune Hospital between March 29, 2017, and October 31, 2017. In the study, basic criteria such as the patients' history, physical examination findings, and the use of compression stockings were evaluated. Read More

    Relationship between Response to PDE5 Inhibitors and Penile Duplex Doppler Ultrasound in Erectile Dysfunction.
    Med Sci (Basel) 2018 Mar 26;6(2). Epub 2018 Mar 26.
    Department of Urology, Giresun University Faculty of Medicine, Giresun, Sağlık Uygulama ve Araştırma Hastanesi Nizamiye Mah. Mumcular Sok. No: 1/1, 1 nolu Sağlık Ocağı Arkası, Merkez, Giresun P.K. 28200, Turkey.
    The relationship between the results of penile duplex Doppler ultrasound (PDDU) and response to vardenafil was investigated in patients diagnosed with erectile dysfunction (ED). Data from 148 patients with ED were analyzed retrospectively. Patients who did not respond to therapy were classified in to Group I ( = 32), those who responded partially were classified into Group II ( = 40), and complete responders were classified into Group III ( = 76). Read More

    [Radiological imaging of acute infectious and non-infectious enterocolitis].
    Radiologe 2018 Apr;58(4):302-311
    Klinik für diagnostische und interventionelle Radiologie und Neuroradiologie, Clemenshospital Münster, Düesbergweg 124, 48153, Münster, Deutschland.
    Background: Computed tomography (CT) is often used as the initial diagnostic test in patients with inflammatory and infectious types of enterocolitis. The differential diagnosis is broad, including infectious, non-infectious and vascular causes, which have substantially different management strategies. Although a definitive diagnosis often relies on endoscopic biopsy results, stool culture results or other clinical features, radiologists often help to guide the diagnosis. Read More

    Service evaluation project - Are local recommendations for onward referral to a specialist menopause clinic required to translate guidelines into practice?
    Post Reprod Health 2018 Jan 1:2053369118762241. Epub 2018 Jan 1.
    iCASH Clinic, Cambridge, UK.
    Objective Referral audit - are local recommendations required to translate guideline to practice? Study design In total, 50 consecutive, anonymised referral letters reviewed during the initial consultation in a specialist menopause clinic; the reasons for referral along with the patient's age and the source of referral were analysed. Results Several common reasons for referral were identified. Sexual dysfunction, including loss of libido and dyspareunia, resulted in 11 (22%) referrals. Read More

    A dairy worker with fever and an abnormal echocardiogram.
    Heart Asia 2017 11;9(2):e010915. Epub 2017 Jul 11.
    Department of Cardiology, Christian Medical College and Hospital, Vellore, India.
    Description Of The Case: A 38-year-old male presented with history of progressively increasing dyspnoea of 25 days duration. He gave history of low -grade fever associated with malaise and weight loss over the preceding 6 months. He worked in the dairy industry in the Middle East and returned to India owing to his illness. Read More

    Accuracy of the ACS NSQIP Online Risk Calculator Depends on How You Look at It: Results from the United States Gastric Cancer Collaborative.
    Am Surg 2018 Mar;84(3):358-364
    The objective of this study is to assess the accuracy of the American College of Surgeons National Surgical Quality Improvement Program online risk calculator for estimating risk after operation for gastric cancer using the United States Gastric Cancer Collaborative. Nine hundred and sixty-five patients who underwent resection of gastric adenocarcinoma between January 2000 and December 2012 at seven academic medical centers were included. Actual complication rates and outcomes for patients were compared. Read More

    Clinical management of non-healing wounds.
    Nurs Stand 2018 Mar;32(29):48-63
    Primary care and tissue viability, Faculty of Health, Social Care and Education, Kingston University and St George's, University of London, London, England.
    Chronic wounds are defined as those that have failed to heal after three months. There are various intrinsic and extrinsic factors that may result in the development of chronic wounds, including comorbidities such as diabetes mellitus and venous insufficiency, and lifestyle factors such as obesity, alcohol consumption and smoking. Chronic wounds represent a significant burden on healthcare resources and can have a negative effect on patients' quality of life. Read More

    Cutaneous Manifestations of Chronic Vascular Disease.
    Prog Cardiovasc Dis 2018 Mar 10. Epub 2018 Mar 10.
    Division of Cardiovascular Medicine, Ohio State University Wexner Medical Center, Columbus, OH. Electronic address:
    In the contemporary era of medical diagnosis via sophisticated radiographic imaging and/or comprehensive serological testing, a focused physical examination remains paramount in recognizing the cutaneous manifestations of chronic vascular disease. Recognition of the unique cutaneous signs of lymphatic and venous hypertension assists in the diagnosis as well as the staging and classification of both lymphedema and chronic venous insufficiency. Awareness of explicit dermatologic vasomotor manifestations aids not only in the identification of acrocyanosis, Raynaud phenomenon, pernio, and erythromelalgia but also mitigates confusion related to their clinical overlap. Read More

    Correlation between venous pressure gradients and intravascular ultrasound in the diagnosis of iliac vein compression syndrome.
    J Vasc Surg Venous Lymphat Disord 2018 Mar 8. Epub 2018 Mar 8.
    Department of Radiology, Arizona Heart Hospital, Phoenix, Ariz.
    Objective: The objective of this study was to evaluate the correlation between venous pressure gradients (VPGs) and intravascular ultrasound (IVUS) for the diagnosis of caval-iliac venous obstructions in patients with advanced chronic venous insufficiency.

    Methods: Fifty patients with advanced chronic venous insufficiency symptoms (Clinical, Etiology, Anatomy, and Pathophysiology class 3 to 6) were prospectively submitted to multiplanar venography (MV) with intravenous pressure measurements and IVUS. The patients' lower limbs were divided accordingly: group I, limbs with <50% obstruction on IVUS (n = 49); and group II, limbs with ≥50% obstruction on IVUS (n = 51). Read More

    Thromboprophylaxis in cancer patients in hospice.
    Adv Clin Exp Med 2018 Feb;27(2):283-289
    Department of Oncology, Medical University of Bialystok, Poland.
    Advanced cancer patients in hospice are at notably increased risk of venous thromboembolism (VTE) due to age, local and distal advancement of the malignancy and bed confinement, among other factors. Asymptomatic VTE prevalence among palliative care patients has been found to reach 50%, whereas the clinically overt form occurs in 10%. Hospice patients are frequently given medications increasing VTE risk, for instance megestrol which is a drug commonly used in cancer cachexia. Read More

    A Retrospective Study Comparing 2 Approaches to Catheter-Directed Thrombolysis for Acute Deep Venous Thrombosis.
    Ann Vasc Surg 2018 Mar 5. Epub 2018 Mar 5.
    Department of Vascular Surgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
    Background: To compare the clinical efficacy and safety of catheter-directed thrombolysis (CDT) using the anterior tibial vein approach (ATVA) and popliteal vein approach (PVA) for acute lower-extremity deep venous thrombosis (LEDVT).

    Methods: From March 2014 to October 2015, 63 patients with unilateral acute extensive LEDVT were enrolled in this study: 36 patients received CDT via the PVA group, and 27 patients received CDT via the ATVA group. Limb circumference, thrombus score, complications, thrombolytic time, and the amount of thrombolytic agents administered were recorded. Read More

    Standards for recanalisation of chronic venous outflow obstructions.
    Vasa 2018 Mar 8:1-8. Epub 2018 Mar 8.
    2 University Clinic Heidelberg, Heidelberg, Germany.
    Postthrombotic syndrome (PTS) is the most common complication after iliofemoral deep vein thrombosis. It reduces quality of life and increases deep vein thrombosis (DVT)-related costs. The clinical symptoms and severity of PTS may vary; the most common symptoms include edema, pain (venous claudication), hyperpigmentation, lipodermatosclerosis, and ulceration. Read More

    Design and evaluation of the psychometric properties of a self-questionnaire on patient adherence to wearing elastic compression stockings.
    Phlebology 2018 Jan 1:268355518762824. Epub 2018 Jan 1.
    4 Vascular medicine, Caen, France.
    Background Patients' adherence to elastic compression stockings is difficult to evaluate, and therefore we create a short self-questionnaire and validate its psychometric properties. Methods We reduce the questions with Varimed rotation analysis, evaluate its internal consistency using Cronbach's alpha test and its external validity by comparison to electronic thermic captors. Receiver operating characteristic (ROC) analysis was used to determine a threshold and determine its sensitivity and specificity. Read More

    Altered velocity gradient in lower limb chronic venous disease.
    Phlebology 2018 Jan 1:268355518762854. Epub 2018 Jan 1.
    1 Vascular Disease Center, Unit of Translational Surgery, University of Ferrara, Ferrara, Italy.
    Background In physiology, velocity of the deep venous compartment is higher than the one in the saphenous compartment which is higher than the one in the tributaries. Considering that velocity variation is associated with changes in the pressure gradient, aim of the present study is to assess changes in venous kinetics in case of superficial chronic venous disease, so to provide further clues in venous drainage direction determination. Methods Venous ultrasound scanning was performed on 40 lower limbs of 28 chronic venous disease patients (C2-6Ep,As,Pr). Read More

    FTIR spectroscopy of chronic venous leg ulcer exudates: an approach to spectral healing marker identification.
    Analyst 2018 Mar;143(7):1583-1592
    Laboratorio de Estudios Farmacéuticos y Biotecnología Farmacéutica, Instituto de Biotecnología Farmacéutica y Alimentaria (INBIOFAL), San Miguel de Tucumán, Tucumán, Argentina.
    Chronic venous leg ulcer (CVLU) arises as a chronic venous insufficiency complication and is a major cause of morbidity throughout the world. Our hypothesis is that the CVLU exudate composition is a biochemical representation of the wound clinical state. Then, Fourier Transform Infrared (FTIR) spectroscopy could be a useful and less-invasive technique to study the clinical state of the ulcer. Read More

    Influence of ulceration etiology on the global quality of life and its specific dimensions, including the control of pain, in patients with lower limb vascular insufficiency.
    Postepy Dermatol Alergol 2017 Oct 31;34(5):471-477. Epub 2017 Oct 31.
    Department of Neurological and Neurosurgical Nursing, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland.
    Introduction: The results of previous studies suggest that the quality of life in patients with lower limb ulcerations is markedly poorer than in the general population - with regard to physical, mental and social spheres. This complex character of that parameter necessitates comprehensive analyses of its specific aspects, including the level of the acceptance of illness and associated pain symptoms.

    Aim: To compare the quality of life and its specific dimensions in patients with lower limb ulcerations of various etiology. Read More

    Thermal and Nonthermal Endovenous Ablation Options for Treatment of Superficial Venous Insufficiency.
    Surg Clin North Am 2018 Apr;98(2):385-400
    Vascular Surgery Clinic, Duke Regional Hospital, 407 Crutchfield Street, Durham, NC 27704, USA.
    Open saphenous removal, phlebectomy, and venous ligation were historic mainstays of surgical treatment of venous disease. Duplex ultrasound has become standard to diagnose venous insufficiency. Percutaneous modalities have allowed treatments to include thermal and nonthermal endovenous ablation. Read More

    Open Surgical Reconstruction for Deep Venous Occlusion and Valvular Incompetence.
    Surg Clin North Am 2018 Apr;98(2):373-384
    Division of Vascular Surgery, Department of Surgery, Indiana University School of Medicine, 1801 North Senate Boulevard, Suite 3500, Indianapolis, IN 46202, USA.
    This article considers the potential options for open deep venous reconstructions based on pathologic complication (obstruction vs insufficiency), anatomic location, presence of disease-free venous architecture, and patient need. Other things being equal, less invasive techniques and disease locations will be attempted as first-line therapy. When other options fail and symptoms persist, open venous surgery by means of bypass for obstructive disease and valve repair or replacement for deep venous insufficiency remains a viable option. Read More

    Pathophysiology of Chronic Venous Disease and Venous Ulcers.
    Surg Clin North Am 2018 Apr 5;98(2):337-347. Epub 2018 Jan 5.
    Harvard Medical School, VA Boston Healthcare System, Brigham and Women's Hospital, Boston, MA, USA; VA Boston HCS, Surg 112, 1400 VFW Parkway, West Roxbury, MA 02132, USA. Electronic address:
    Chronic venous disease and venous leg ulceration are a common disease affecting millions of individuals. The fundamental problem is venous hypertension with resultant clinical manifestations of venous disease including varicose veins, skin changes, and venous leg ulceration. The pathophysiology leading to venous hypertension is complex and multifactorial, involving genetic predisposition, environmental factors, hormones, endothelial dysfunction, inflammatory cells and molecules and activation on the endothelium and vein wall, and disturbances in the balance of cytokines and matrix metalloproteinases. Read More

    Advances in Operative Thrombectomy for Lower Extremity Venous Thrombosis.
    Surg Clin North Am 2018 Apr 18;98(2):267-277. Epub 2017 Dec 18.
    Department of Surgery, Veterans Affairs Portland Health Care System, Oregon Health & Sciences University, 3710 Southwest US Veterans Hospital Road, P3-OC, Portland, OR 97239, USA. Electronic address:
    Lower extremity deep venous thrombosis is a leading cause of morbidity and mortality. The mainstay of therapy is medical. However, anticoagulation does not remove the thrombus and restore venous patency. Read More

    Duplex Ultrasound for the Diagnosis of Acute and Chronic Venous Diseases.
    Surg Clin North Am 2018 Apr 24;98(2):201-218. Epub 2017 Dec 24.
    Division of Vascular and Endovascular Surgery, Department of Surgery, Stony Brook University Medical Center, 101 Nicolls Road, Stony Brook, NY 11974, USA. Electronic address:
    Venous diseases are highly prevalent, mostly caused by valve incompetence and/or obstruction of the vein lumen. Signs and symptoms are diverse and unspecific. Careful clinical assessment and imaging interpretation are crucial to diagnosis. Read More

    Immunomodulation as Rescue for Chronic Atonic Skin Wounds.
    Trends Immunol 2018 Apr 27;39(4):341-354. Epub 2018 Feb 27.
    Department of Development & Regeneration & Department of Plastic & Reconstructive Surgery, University Hospitals Leuven and KU Leuven, Leuven, Belgium.
    Chronic skin wounds, caused by arterial or venous insufficiency or by physical pressure, constitute an increasing medical problem as populations age. Whereas typical wounds are characterized by local inflammation that participates in the healing process, atonic wounds lack inflammatory markers, such as neutrophil infiltration, and generally do not heal. Recently, prominent roles in the immunopathology of chronic wounds were attributed to dysregulations in specific cytokines, chemokines, matrix metalloproteinases (MMPs), and their substrates. Read More

    Underutilization of Thrombolytic Therapy for Patients Diagnosed with Acute Deep Venous Thrombosis in the Outpatient Setting.
    Ann Vasc Surg 2018 Feb 28. Epub 2018 Feb 28.
    Division of Vascular Surgery, Department of Surgery, Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA. Electronic address:
    Background: Catheter-directed thrombolysis (CDT) has been shown to be a safe and effective treatment for the management of acute iliofemoral deep venous thrombosis (DVT). The potential benefits of this therapy include more rapid resolution of symptoms and possible reduction in the long-term sequelae. Many patients diagnosed with DVT in the inpatient setting have contraindications to lytic therapy, but less is known regarding the suitability of thrombolysis for outpatients diagnosed with acute DVT. Read More

    Physical Properties of Venous Stents: An Experimental Comparison.
    Cardiovasc Intervent Radiol 2018 Feb 28. Epub 2018 Feb 28.
    Department of Radiology, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany.
    Purpose: Iliocaval obstruction is a substantial contributor to chronic venous insufficiency and is increasingly being treated endovascularly with angioplasty and stent placement. Utilization of an appropriate stent for treatment is pivotal; however, until today, mechanical properties of venous stents remain unknown.

    Materials And Methods: We analyzed the radial resistive force, the chronic outward force, as well as the crush resistance of seven stent models [Zilver Vena (Cook, Bjaeverskov, Denmark), Sinus Venous, Sinus Obliquus and Sinus XL Flex (Optimed, Ettlingen, Germany), Vici (Veniti; St. Read More

    Three-year follow-up and quality of life of endovenous radiofrequency ablation of the great saphenous vein with the ClosureFast™ procedure: Influence of BMI and CEAP class.
    Vascular 2018 Jan 1:1708538118762066. Epub 2018 Jan 1.
    4 Department of Cardiology, IRCCS Istituto Auxologico Italiano, Milan, Italy.
    Purpose Endovascular ablation of the great saphenous vein has been proposed as a less invasive alternative to conventional ligation and stripping of varicose veins. Outcomes of patients treated with the radiofrequency ablation ClosureFast™ system over an eight-year period from a single-center were evaluated. Methods Three-year follow-up data included duplex ultrasound scan, complication rate, and questionnaires to assess patients' QOL, level of pain, and days off work. Read More

    The Role of Complex Treatment in Mixed Leg Ulcers - A Case Report of Vascular, Surgical and Physical Therapy.
    Open Access Maced J Med Sci 2018 Jan 1;6(1):67-70. Epub 2018 Jan 1.
    Università Degli Studi "G. Marconi", Rome, Italy.
    Background: Leg ulcers are a burden to patients, their families and society. The second most common cause of chronic leg ulcers is the mixed arterio-venous type. An 80-year-old female patient presented to our department due to painful enlarging chronic leg ulcer of mixed arteriovenous origin on her left lower leg. Read More

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