3,371 results match your criteria Venezuelan Encephalitis


Publisher Correction: Complex virome in feces from Amerindian children in isolated Amazonian villages.

Nat Commun 2018 Nov 14;9(1):4852. Epub 2018 Nov 14.

Blood Systems Research Institute, San Francisco, CA, 94118, USA.

In the original version of this Article, the affiliation details for Eric Delwart were incorrectly given as 'Blood Systems Research Institute, San Francisco, CA 94118, USA and Amazonic Center for Research and Control of Tropical Diseases (CAICET), Puerto Ayacucho 7101, Venezuela'. The correct affiliations are 'Blood Systems Research Institute, San Francisco, CA 94118, USA and Department of Laboratory Medicine, University of California at San Francisco, San Francisco, CA 94118, USA'. This has been corrected in both the PDF and HTML versions of the Article. Read More

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November 2018

Association of Age With Blood Pressure Across the Lifespan in Isolated Yanomami and Yekwana Villages.

JAMA Cardiol 2018 Nov 14. Epub 2018 Nov 14.

Department of Biochemistry and Microbiology, Rutgers University, New Brunswick, New Jersey.

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November 2018

Induction of Expandable Adipose-Derived Mesenchymal Stem Cells from Aged Mesenchymal Stem Cells by a Synthetic Self-Replicating RNA.

Int J Mol Sci 2018 Nov 6;19(11). Epub 2018 Nov 6.

Department of Regenerative Medicine, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan.

Adipose-derived mesenchymal stem cells (ADSCs) have attracted attention due to their potential for use in the treatment of various diseases. However, the self-renewal capacity of ADSCs is restricted and their function diminishes during passage. We previously generated induced tissue-specific stem cells from mouse pancreatic cells using a single synthetic self-replicating Venezuelan Equine Encephalitis (VEE)-reprogramming factor (RF) RNA replicon (SR-RNA) expressing the reprogramming factors POU class 5 homeobox 1 (OCT4), Krueppel-like factor 4 (KLF4), Sex determining region Y-box 2 (SOX2), and Glis Family Zinc Finger 1 (GLIS1). Read More

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November 2018

Mitochondrial-Directed Antioxidant Reduces Microglial-Induced Inflammation in Murine In Vitro Model of TC-83 Infection.

Viruses 2018 Nov 2;10(11). Epub 2018 Nov 2.

National Center for Biodefense and Infectious Diseases, George Mason University, Manassas, VA 20110, USA.

Venezuelan equine encephalitis virus (VEEV) is an arbovirus that is associated with robust inflammation that contributes to neurodegenerative phenotypes. In addition to triggering central nervous system (CNS) inflammation, VEEV will also induce mitochondrial dysfunction, resulting in increased cellular apoptosis. In this study, we utilize the TC-83 strain of VEEV to determine the role of mitochondrial oxidative stress in mediating inflammation elicited by murine brain microglial cells. Read More

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November 2018
3 Reads

Validation study of a scale for assessing three personality functional dimensions among Venezuelan HIV-positive patients.

Psychol Res Behav Manag 2018 12;11:459-470. Epub 2018 Oct 12.

Unit of Social Work and Sciences for Human Development, Autonomous University of Tamaulipas, Ciudad Victoria, Tamaulipas, Mexico.

Background: Personality has been recognized as a key variable in the prediction of treatment adherence and health care behaviors in patients living with chronic diseases.

Purpose: In order to contribute to the prediction of treatment-adherence behaviors among HIV-positive patients, this study aimed to test the metric properties of the 12-item Stress-Related Situations Scale (SRSS-12), which assesses four interactive styles of personality related to stressful situations when receiving treatment for a chronic disease.

Patients And Methods: This cross-sectional study was performed with a nonprobability sampling between May and June 2016. Read More

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October 2018

Phylogenomic Analysis of the Explosive Adaptive Radiation of the Espeletia Complex (Asteraceae) in the Tropical Andes.

Syst Biol 2018 11;67(6):1041-1060

Laboratoire d'Ecologie Alpine, UMR 5553, Université Grenoble Alpes-CNRS, Grenoble, France.

The subtribe Espeletiinae (Asteraceae), endemic to the high-elevations in the Northern Andes, exhibits an exceptional diversity of species, growth-forms, and reproductive strategies. This complex of 140 species includes large trees, dichotomous trees, shrubs and the extraordinary giant caulescent rosettes, considered as a classic example of adaptation in tropical high-elevation ecosystems. The subtribe has also long been recognized as a prominent case of adaptive radiation, but the understanding of its evolution has been hampered by a lack of phylogenetic resolution. Read More

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November 2018

The current syndemic in Venezuela: Measles, malaria and more co-infections coupled with a breakdown of social and healthcare infrastructure. Quo vadis?

Travel Med Infect Dis 2018 Oct 14. Epub 2018 Oct 14.

Committe on Travel Medicine, Pan-American Association of Infectious Diseases (API), Panama City, Panama; Department of Infectious Diseases and Tropical Medicine, Clínica IDB Cabudare, Instituto de Investigaciones Biomédicas IDB, Barquisimeto, 3023, Lara, Venezuela; Infectious Diseases Research Branch, Venezuelan Science Incubator and the Zoonosis and Emerging Pathogens regional Collaborative Network, Cabudare, 3023, Lara, Venezuela; Laboratorio de Señalización Celular y Bioquímica de Parásitos, Instituto de Estudios Avanzados (IDEA), Caracas, Caracas, Venezuela.

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October 2018
2 Reads

Complex virome in feces from Amerindian children in isolated Amazonian villages.

Nat Commun 2018 10 15;9(1):4270. Epub 2018 Oct 15.

Blood Systems Research Institute, San Francisco, CA, 94118, USA.

The number of viruses circulating in small isolated human populations may be reduced by viral extinctions and rare introductions. Here we used viral metagenomics to characterize the eukaryotic virome in feces from healthy children from a large urban center and from three Amerindian villages with minimal outside contact. Numerous human enteric viruses, mainly from the Picornaviridae and Caliciviridae families, were sequenced from each of the sites. Read More

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October 2018
5 Reads

Subspecies-level systematics and affinities of Cheimas Thieme-an endemic genus of the subparamo of the Venezuelan Cordillera de Mérida (Lepidoptera: Nymphalidae, Satyrinae).

Zootaxa 2018 May 23;4422(2):219-243. Epub 2018 May 23.

Nature Education Centre, Jagiellonian University, Gronostajowa 5, 30-387 Kraków, Poland Entomology Department, Institute of Zoology and Biomedical Research, Jagiellonian University, Gronostajowa 9, 30-387 Kraków, Poland..

The validity of the monobasic neotropical butterfly genus Cheimas Thieme (Nymphalidae, Satyrinae, Satyrini, Pronophilina) is discussed, and confirmed based on morphological and molecular data. Cheimas opalinus (Staudinger), endemic to the Venezuelan Cordillera de Mérida, and considered prior to this study to be monotypic and restricted to the central part of the range, is demonstrated to be polytypic and more widely distributed. Five subspecies are recognised, differing mostly in their dorsal patterns, in particular the shape and colour of hindwing greenish-blue patch. Read More

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May 2018
2 Reads

Tepuidessus grulai sp. nov. from Acopán Tepui in Venezuela (Coleoptera: Dytiscidae: Hydroporinae: Bidessini).

Zootaxa 2018 Jun 18;4434(3):561-572. Epub 2018 Jun 18.

Department of Zoology, Faculty of Natural Sciences, Comenius University in Bratislava, Ilkovičova 6, 842 15 Bratislava, Slovakia..

We report the discovery of the second Bidessini diving beetle species from a Venezuelan table-top mountain (also referred to as "tepui"). Tepuidessus grulai sp. nov. Read More

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Zoonotic Viral Diseases of Equines and Their Impact on Human and Animal Health.

Open Virol J 2018 31;12:80-98. Epub 2018 Aug 31.

ICAR-National Research Centre on Equines, Hisar-125001, India.

Introduction: Zoonotic diseases are the infectious diseases that can be transmitted to human beings and vice versa from animals either directly or indirectly. These diseases can be caused by a range of organisms including bacteria, parasites, viruses and fungi. Viral diseases are highly infectious and capable of causing pandemics as evidenced by outbreaks of diseases like Ebola, Middle East Respiratory Syndrome, West Nile, SARS-Corona, Nipah, Hendra, Avian influenza and Swine influenza. Read More

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August 2018
10 Reads

Comparison of Aerosol- and Percutaneous-acquired Venezuelan Equine Encephalitis in Humans and Nonhuman Primates for Suitability in Predicting Clinical Efficacy under the Animal Rule.

Comp Med 2018 Oct 3;68(5):380-395. Epub 2018 Oct 3.

Joint Vaccine Acquisition Program, Medical Countermeasure Systems, Fort Detrick, Maryland.

Licensure of medical countermeasure vaccines to protect against aerosolized Venezuelan equine encephalitis virus (VEEV) requires the use of the Animal Rule to assess vaccine efficacy, because human studies are not feasible or ethical. We therefore performed a retrospective study of VEE cases that occurred in at-risk laboratory workers and support personnel during the United States Biowarfare Program (1943-1969) to better define percutaneous- and aerosol-acquired VEE in humans and to compare these results with those described for the NHP model (in which high-dose aerosol VEEV challenge led to more severe encephalitis than parenteral challenge). Record review and analysis of 17 aerosol- and 23 percutaneous-acquired human cases of VEE included incubation period, symptoms, physical examination findings, and markers of infection. Read More

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October 2018
9 Reads

The genetic adjuvant IL-12 enhances the protective efficacy of a DNA vaccine for Venezuelan equine encephalitis virus delivered by intramuscular injection in mice.

Antiviral Res 2018 Nov 27;159:113-121. Epub 2018 Sep 27.

U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA. Electronic address:

We have previously shown that DNA vaccines expressing codon-optimized alphavirus envelope glycoprotein genes protect both mice and non-human primates from viral challenge when delivered by intramuscular electroporation (IM-EP). To determine if we could achieve equivalent immunogenicity and protective efficacy in the absence of electroporation, we co-delivered our Venezuelan equine encephalitis virus (VEEV) DNA vaccine with DNA plasmids expressing genetic adjuvants designed to augment immune responses. We tested the T1-inducing cytokine IL-12 as well as the granulocyte growth factor GM-CSF, both of which have demonstrated significant adjuvant effect when included in clinical DNA vaccine formulations. Read More

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November 2018
6 Reads

Cutaneous features of Zika virus infection: a clinicopathological overview.

Clin Exp Dermatol 2019 Jan 28;44(1):13-19. Epub 2018 Sep 28.

Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA.

Zika virus (ZIKV) is an emerging mosquito-borne flavivirus transmitted mainly by Aedes species of mosquitos. Although the infection is usually mild and self-limiting, it is emerging as a public health challenge in tropical and subtropical countries owing to its unprecedented pathogenicity and increased risk for fetal malformations and neurological symptoms. Cutaneous manifestations as for other mosquito-borne viruses remain a hallmark of the disease. Read More

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January 2019
6 Reads

The Interferon-Induced Exonuclease ISG20 Exerts Antiviral Activity through Upregulation of Type I Interferon Response Proteins.

mSphere 2018 09 19;3(5). Epub 2018 Sep 19.

Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

Type I interferon (IFN)-stimulated genes (ISGs) have critical roles in inhibiting virus replication and dissemination. Despite advances in understanding the molecular basis of ISG restriction, the antiviral mechanisms of many remain unclear. The 20-kDa ISG ISG20 is a nuclear 3'-5' exonuclease with preference for single-stranded RNA (ssRNA) and has been implicated in the IFN-mediated restriction of several RNA viruses. Read More

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September 2018
3 Reads

Lipid-Coated Mesoporous Silica Nanoparticles for the Delivery of the ML336 Antiviral to Inhibit Encephalitic Alphavirus Infection.

Sci Rep 2018 Sep 18;8(1):13990. Epub 2018 Sep 18.

Department of Biotechnology and Bioengineering, Sandia National Laboratories, Livermore, CA, USA.

Venezuelan equine encephalitis virus (VEEV) poses a major public health risk due to its amenability for use as a bioterrorism agent and its severe health consequences in humans. ML336 is a recently developed chemical inhibitor of VEEV, shown to effectively reduce VEEV infection in vitro and in vivo. However, its limited solubility and stability could hinder its clinical translation. Read More

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September 2018
1 Read

Infectious disease implications of large-scale migration of Venezuelan nationals.

J Travel Med 2018 Jan;25(1)

Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Canada.

Background: The ongoing economic and political crisis in Venezuela has resulted in a collapse of the healthcare system and the re-emergence of previously controlled or eliminated infectious diseases. There has also been an exodus of Venezuelan international migrants in response to the crisis. We sought to describe the infectious disease risks faced by Venezuelan nationals and assess the international mobility patterns of the migrant population. Read More

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January 2018

Author Correction: Novel inhibitors targeting Venezuelan equine encephalitis virus capsid protein identified using In Silico Structure-Based-Drug-Design.

Sci Rep 2018 Sep 4;8(1):13487. Epub 2018 Sep 4.

Nuclear Signaling Laboratory, Department of Biochemistry and Molecular Biology School of Biomedical Sciences, Monash University, Melbourne, Australia.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper. Read More

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September 2018
3 Reads

Arboviruses and pregnancy: maternal, fetal, and neonatal effects.

Lancet Child Adolesc Health 2017 Oct 10;1(2):134-146. Epub 2017 Aug 10.

Institut Pasteur, Biology of Infection Unit, Paris, France; Inserm U1117, Paris, France; Paris-Descartes University, Sorbonne Paris Cité, Centre d'Infectiologie Necker-Pasteur, Necker-Enfants Malades University Hospital, Institut Imagine, Assistance Publique-Hôpitaux de Paris, Paris, France. Electronic address:

Arboviruses are an expanding public health threat, with pregnant women facing unique complications from arbovirus infections. These infections, such as dengue and Crimean-Congo haemorrhagic fever, can be more severe in pregnant women than in the general population. Vertical transmission is reported for many arboviruses and can severely affect pregnancy outcome. Read More

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October 2017
17 Reads

Changes in the Gut Microbiota of Urban Subjects during an Immersion in the Traditional Diet and Lifestyle of a Rainforest Village.

mSphere 2018 08 29;3(4). Epub 2018 Aug 29.

Department of Medicine, New York University Langone Medical Center, New York, New York, USA

People living traditional lifestyles have higher gut microbiota diversity than urban subjects. We hypothesized that shifting lifestyles from an urban environment to a traditional rainforest village would lead to changes in the microbiota of visitors, which would become more similar to the microbiota of villagers. Here, we characterized at different time points the microbiota of 7 urban visitors (5 adults and 2 children) staying in a rainforest Amerindian village for 16 days and compared them with a reference collection of samples from age-matched local villagers. Read More

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August 2018
14 Reads

Genetic control of alphavirus pathogenesis.

Mamm Genome 2018 08 27;29(7-8):408-424. Epub 2018 Aug 27.

Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

Alphaviruses, members of the positive-sense, single-stranded RNA virus family Togaviridae, represent a re-emerging public health concern worldwide as mosquito vectors expand into new geographic ranges. Members of the alphavirus genus tend to induce clinical disease characterized by rash, arthralgia, and arthritis (chikungunya virus, Ross River virus, and Semliki Forest virus) or encephalomyelitis (eastern equine encephalitis virus, western equine encephalitis virus, and Venezuelan equine encephalitis virus), though some patients who recover from the initial acute illness may develop long-term sequelae, regardless of the specific infecting virus. Studies examining the natural disease course in humans and experimental infection in cell culture and animal models reveal that host genetics play a major role in influencing susceptibility to infection and severity of clinical disease. Read More

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August 2018
16 Reads

Experimental studies on effects of temperature on oil and water relative permeability in heavy-oil reservoirs.

Sci Rep 2018 Aug 21;8(1):12530. Epub 2018 Aug 21.

School of Energy Resources, China University of Geosciences(Beijing), 29 Xueyuan Road, Beijing, 100083, China.

A heavy-oil sample derived from a block of Venezuelan oil was used to investigate effects of temperature on relative permeability to oil and water. Measurements of relative permeability were based on one-dimensional core-flow simulated systems using an unsteady-state technique at different temperatures, and then impact rules of temperature dependency were discussed. Both water and heavy oil in cores were reconfigured under the consideration of actual reservoir conditions. Read More

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Modelling opportunity: An examination of quadratic effects of adolescent Venezuelan substance use.

Drug Alcohol Rev 2018 11 15;37(7):865-873. Epub 2018 Aug 15.

Department of Human Development and Family Science, Oklahoma State University, Stillwater, USA.

Introduction And Aims: Numerous studies have found a linear relationship between an exposure opportunity and age of first drug use. This study further tests this relationship by exploring whether a quadratic exposure opportunity best fits the data on age of first use and whether gender moderates this relationship. That is, is there a peak age in which the transition to use occurs for male compared to female adolescents?

Design And Methods: A sample of 1716 adolescents from 14 public and private schools, representative of two school districts in Caracas, Venezuela, was examined using a zero-inflated Poisson modelling approach to test for quadratic effects. Read More

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November 2018
6 Reads

Alice in Wonderland syndrome: a novel neurological presentation of Zika virus infection.

J Neurovirol 2018 Oct 13;24(5):660-663. Epub 2018 Aug 13.

Department of Biology, College of Liberal Arts and Sciences, University of Florida, Gainesville, FL, USA.

Zika virus (ZIKV) is a flavivirus endemic in Africa and Southern Asian countries, which has recently emerged in unprecedented epidemic proportions around the world. Although ZIKV infection is often asymptomatic or distinguished by non-specific influenza-like symptoms, an increase in its pathogenicity and biological behavior has been the hallmark of the current pandemic. Increasing evidence suggests that neurotropic strains of ZIKV have evolved from less pathogenic strains of the virus. Read More

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October 2018
10 Reads

Direct and indirect pro-inflammatory cytokine response resulting from TC-83 infection of glial cells.

Virulence 2018 ;9(1):1403-1421

a National Center for Biodefense and Infectious Diseases , George Mason University , Manassas , VA , USA.

Venezuelan equine encephalitis virus (VEEV) is a neurotropic arbovirus that is highly infectious as an aerosol and can result in an encephalitic phenotype in infected individuals. VEEV infections are known to be associated with robust inflammation that eventually contributes to neurodegenerative phenotypes. In this study, we utilize the TC-83 strain of VEEV, which is known to induce the expression of IL-6, IL-8, and other pro-inflammatory cytokines. Read More

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January 2018
2 Reads

Protective efficacy of monovalent and trivalent recombinant MVA-based vaccines against three encephalitic alphaviruses.

Vaccine 2018 08 20;36(34):5194-5203. Epub 2018 Jul 20.

Defence Research and Development Canada, Suffield Research Centre, Box 4000, Station Main, Medicine Hat, AB T1A 8K6, Canada.

The three encephalitic alphaviruses, western, eastern, and Venezuelan equine encephalitis viruses (WEEV, EEEV, and VEEV) are potential biothreat agents due to high infectivity through aerosol exposure, ease of production in large amounts, and relative stability in the environment. Currently, there is no licensed vaccine for human use to these three encephalitic alphaviruses, and efforts to move vaccine candidates forward into clinical trials have not been successful. In this study, the modified vaccinia Ankara-Bavarian Nordic (MVA-BN®) vaccine platform was used to construct and produce three monovalent recombinant MVA-BN-based encephalitic alphavirus vaccines, MVA-BN-W, MVA-BN-E, and MVA-BN-V. Read More

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August 2018
3 Reads

Isolation of Complete Equine Encephalitis Virus Genome from Human Swab Specimen, Peru.

Emerg Infect Dis 2018 Aug;24(8):1578-1580

While studying respiratory infections in Peru, we identified Venezuelan equine encephalitis virus (VEEV) in a nasopharyngeal swab, indicating that this alphavirus can be present in human respiratory secretions. Because VEEV may be infectious when aerosolized, our finding is relevant for the management of VEEV-infected patients and for VEEV transmission studies. Read More

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August 2018
1 Read

Repurposed FDA-Approved drug sorafenib reduces replication of Venezuelan equine encephalitis virus and other alphaviruses.

Antiviral Res 2018 Sep 5;157:57-67. Epub 2018 Jul 5.

National Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason University, Manassas, VA, USA. Electronic address:

The New World alphaviruses -Venezuelan, eastern, and western equine encephalitis viruses (VEEV, EEEV, and WEEV respectively) - cause a febrile disease that is often lethal in equines and children and leads to long-term neurological sequelae in survivors. Endemic to the Americas, epizootic outbreaks of the three viruses occur sporadically in the continental United States. All three viruses aerosolize readily, replicate to high titers in cell culture, and have low infectious doses. Read More

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September 2018
6 Reads

A Multiagent Alphavirus DNA Vaccine Delivered by Intramuscular Electroporation Elicits Robust and Durable Virus-Specific Immune Responses in Mice and Rabbits and Completely Protects Mice against Lethal Venezuelan, Western, and Eastern Equine Encephalitis Virus Aerosol Challenges.

J Immunol Res 2018 3;2018:8521060. Epub 2018 Jun 3.

United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702-5011, USA.

There remains a need for vaccines that can safely and effectively protect against the biological threat agents Venezuelan (VEEV), western (WEEV), and eastern (EEEV) equine encephalitis virus. Previously, we demonstrated that a VEEV DNA vaccine that was optimized for increased antigen expression and delivered by intramuscular (IM) electroporation (EP) elicited robust and durable virus-specific antibody responses in multiple animal species and provided complete protection against VEEV aerosol challenge in mice and nonhuman primates. Here, we performed a comparative evaluation of the immunogenicity and protective efficacy of individual optimized VEEV, WEEV, and EEEV DNA vaccines with that of a 1 : 1 : 1 mixture of these vaccines, which we have termed the 3-EEV DNA vaccine, when delivered by IM EP. Read More

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October 2018
10 Reads

Environmental drivers of forest structure and stem turnover across Venezuelan tropical forests.

PLoS One 2018 21;13(6):e0198489. Epub 2018 Jun 21.

School of Environmental and Forest Sciences (SEFS), University of Washington, Seattle, Washington, United of States America.

Using data from 50 long-term permanent plots from across Venezuelan forests in northern South America, we explored large-scale patterns of stem turnover, aboveground biomass (AGB) and woody productivity (AGWP), and the relationships between them and with potential climatic drivers. We used principal component analysis coupled with generalized least squares models to analyze the relationship between climate, forest structure and stem dynamics. Two major axes associated with orthogonal temperature and moisture gradients effectively described more than 90% of the environmental variability in the dataset. Read More

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June 2018
2 Reads
3.230 Impact Factor

Complete Genome Sequence of Dengue Virus Serotype 2, Asian/American Genotype, Isolated from the Urine of a Venezuelan Child with Hemorrhagic Fever in 2016.

Genome Announc 2018 Jun 14;6(24). Epub 2018 Jun 14.

Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA

The complete genome sequence was obtained for a 2 isolate from the urine of an 8-year-old girl who was hospitalized with dengue hemorrhagic fever in 2016 in Venezuela. Read More

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June 2018
7 Reads

Did Zika Virus Mutate to Cause Severe Outbreaks?

Trends Microbiol 2018 Oct 11;26(10):877-885. Epub 2018 Jun 11.

Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA.

Zika virus (ZIKV) has challenged the assumed knowledge regarding the pathobiology of flaviviruses. Despite causing sporadic and mild disease in the 50 years since its discovery, Zika virus has now caused multiple outbreaks in dozens of countries worldwide. Moreover, the disease severity in recent outbreaks, with neurological disease in adult and devastating congenital malformations in fetuses, was not previously seen. Read More

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October 2018
12 Reads

Optic neuropathy and congenital glaucoma associated with probable Zika virus infection in Venezuelan patients.

JMM Case Rep 2018 May 14;5(5):e005145. Epub 2018 Mar 14.

Laboratory of Neuroscience, University of Zulia, Maracaibo, Venezuela.

Introduction: Although the current Zika virus (ZIKV) epidemic is a major public health concern, most reports have focused on congenital ZIKV syndrome, its most devastating manifestation. Severe ocular complications associated with ZIKV infections and possible pathogenetic factors are rarely described. Here, we describe three Venezuelan patients who developed severe ocular manifestations following ZIKV infections. Read More

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May 2018
31 Reads

Structural Characterization and Formulation Development of a Trivalent Equine Encephalitis Virus-Like Particle Vaccine Candidate.

J Pharm Sci 2018 Oct 5;107(10):2544-2558. Epub 2018 Jun 5.

Macromolecule and Vaccine Stabilization Center, Department of Pharmaceutical Chemistry, University of Kansas, 2030 Becker Drive, Lawrence, Kansas 66047. Electronic address:

The zoonotic equine encephalitis viruses (EEVs) can cause debilitating and life-threatening disease, leading to ongoing vaccine development efforts for an effective virus-like particle (VLP) vaccine based on 3 strains of EEV (Eastern, Western, and Venezuelan or EEE, WEE and VEE VLPs, respectively). In this work, transmission electron microscopy and light scattering studies showed enveloped, spherical, and ∼70 nm sized VLPs. Biophysical studies demonstrated optimal VLP physical stability in the pH range of 7. Read More

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October 2018
5 Reads

5-α-Reductase type 2 deficiency: is there a genotype-phenotype correlation? A review.

Hormones (Athens) 2018 Jun 20;17(2):197-204. Epub 2018 Apr 20.

Unit of Dentistry, Bambino Gesù Children's Hospital, Rome, Italy.

5-α-Reductase type 2 enzyme catalyzes the conversion of testosterone into dihydrotestosterone, a potent androgen responsible for male sexual development during the fetal period and later during puberty. Its deficiency causes an autosomal recessive disorder of sex development characterized by a wide range of under-virilization of external genitalia in patients with a 46,XY karyotype. Mutations in the SRD5A2 gene cause 5-α-Reductase deficiency; although it is an infrequent disorder, it has been reported worldwide, with mutational heterogeneity. Read More

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June 2018
4 Reads

Genetic, host and environmental factors associated with a high prevalence of Anaplasma marginale.

Ticks Tick Borne Dis 2018 07 21;9(5):1286-1295. Epub 2018 May 21.

Grupo BCEI, Universidad de Antioquia UdeA, Calle 70 No. 52-21, Medellín, Colombia. Electronic address:

Anaplasma marginale is the most prevalent vector-borne pathogen in the livestock industry in Colombia, causing economic losses of approximately USD 4.2 million per year. The present study reports the seasonal transmission patterns, genetic diversity and phylogeographic traits of A. Read More

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Exploration of (hetero)aryl derived thienylchalcones for antiviral and anticancer activities.

Med Chem 2018 May 23. Epub 2018 May 23.

Pharmaceutical Sciences Department, College of Pharmacy, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064. United States.

Background: Search for new antiviral and anticancer agents are essential because of the emergence of drug resistance in recent years. In continuation of our efforts in identifying the new small molecule antiviral and anticancer agents, we identified chalcones as potent antiviral and anticancer agents.

Objective: With the aim of identifying the broad acting antiviral and anticancer agents, we discovered substituted aryl/heteroaryl derived thienyl chalcones as antiviral and anticancer agents. Read More

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May 2018
3 Reads
1.390 Impact Factor

Regional Overview of Specific Populations, Workforce Considerations, Training, and Diseases in Latin America.

Otolaryngol Clin North Am 2018 Jun;51(3):651-658

Pan-American Society of Otorhinolaryngology-Head and Neck Surgery, Atlanta, GA, USA; Venezuelan Society of Otolaryngology, Caracas, Venezuela.

Latin America has significant disparities that make the region vulnerable in the delivery of health care. There is a need to plan comprehensive health care strategies that result in a more robust trained health care workforce, while improving the quality and efficiencies of tertiary public hospitals. This article introduces a survey conducted among otorhinolaryngology leaders in the region that identified the need to strengthen postgraduate programs. Read More

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June 2018
3 Reads

Identification of a novel HLA-C allele, C*02:10:03, in a Venezuelan patient.

HLA 2018 May 17. Epub 2018 May 17.

S.C. Laboratorio di Istocompatibilità/IBMDR, E.O. Ospedali Galliera, Genoa, Italy.

HLA-C*02:10:03 identified in a Venezuelan patient and characterized using next generation sequencing. Read More

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Protein Phosphatase 1α Interacts with Venezuelan Equine Encephalitis Virus Capsid Protein and Regulates Viral Replication through Modulation of Capsid Phosphorylation.

J Virol 2018 08 17;92(15). Epub 2018 Jul 17.

National Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason University, Manassas, Virginia, USA

Protein phosphatase 1 (PP1) is a serine/threonine phosphatase which has been implicated in the regulation of a number of viruses, including HIV-1, Ebolavirus, and Rift Valley fever virus. Catalytic subunits of PP1 (PP1α, PP1β, and PP1γ) interact with a host of regulatory subunits and target a wide variety of cellular substrates through a combination of short binding motifs, including an RVxF motif present in the majority of PP1 regulatory subunits. Targeting the RVxF-interacting site on PP1 with the small molecule 1E7-03 inhibits HIV-1, Ebolavirus, and Rift Valley fever virus replication. Read More

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August 2018
2 Reads

Population-specific genetic modification of Huntington's disease in Venezuela.

PLoS Genet 2018 05 11;14(5):e1007274. Epub 2018 May 11.

Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America.

Modifiers of Mendelian disorders can provide insights into disease mechanisms and guide therapeutic strategies. A recent genome-wide association (GWA) study discovered genetic modifiers of Huntington's disease (HD) onset in Europeans. Here, we performed whole genome sequencing and GWA analysis of a Venezuelan HD cluster whose families were crucial for the original mapping of the HD gene defect. Read More

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May 2018
6 Reads

Human and Equine Infection with Alphaviruses and Flaviviruses in Panamá during 2010: A Cross-Sectional Study of Household Contacts during an Encephalitis Outbreak.

Am J Trop Med Hyg 2018 Jun 3;98(6):1798-1804. Epub 2018 May 3.

Departments of Microbiology & Immunology and Pathology, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas.

Members of the genera (family ) and (family ) are important zoonotic human and equine etiologic agents of neurologic diseases in the New World. In 2010, an outbreak of Madariaga virus (MADV; formerly eastern equine encephalitis virus) and Venezuelan equine encephalitis virus (VEEV) infections was reported in eastern Panamá. We further characterized the epidemiology of the outbreak by studying household contacts of confirmed human cases and of equine cases with neurological disease signs. Read More

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June 2018
7 Reads
2.700 Impact Factor

High Rate of Infection by Only Oncogenic Human Papillomavirus in Amerindians.

mSphere 2018 May-Jun;3(3). Epub 2018 May 2.

Department of Medicine, New York University School of Medicine, New York, New York, USA

Human papillomavirus (HPV), an etiological agent of cervical cancer (CC), has infected humans since ancient times. Amerindians are the furthest migrants out of Africa, and they reached the Americas more than 14,000 years ago. Some groups still remain isolated, and some migrate to towns, forming a gradient spanning urbanization. Read More

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October 2018
4 Reads

Madariaga Virus: Identification of a Lineage III Strain in a Venezuelan Child With Acute Undifferentiated Febrile Illness, in the Setting of a Possible Equine Epizootic.

Clin Infect Dis 2018 Aug;67(4):619-621

Department of Infectious Diseases and Tropical Medicine, Instituto Diagnóstico Barquisimeto (IDB)/ Biomedical Research Institute/IDB Hospital, Barquisimeto, Lara.

We report identification of Madariaga virus (MADV) in plasma and urine samples from a child with acute undifferentiated febrile illness in Venezuela. Our data document the occurrence of milder MADV infections (ie, without encephalitis), with a symptom complex that resembles that seen with other arboviral infections, including dengue and zika. Read More

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August 2018
15 Reads

Mechanisms of the effect of magnesium salts in preeclampsia.

Placenta 2018 Sep 24;69:134-139. Epub 2018 Apr 24.

Cellular and Molecular Physiology Laboratory (CMPL), Division of Obstetrics and Gynaecology, School of Medicine, Faculty of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile; Department of Physiology, Faculty of Pharmacy, Universidad de Sevilla, Seville, Spain; University of Queensland Centre for Clinical Research (UQCCR), Faculty of Medicine and Biomedical Sciences, University of Queensland, Herston, QLD 4029, Australia. Electronic address:

Preeclampsia is a heterogeneous pregnancy-specific syndrome associated with abnormal trophoblast invasion and endothelial dysfunction. Magnesium (Mg) level may be normal or decreased in women with preeclampsia. However, the use of Mg salts, such as Mg sulphate, are useful in reducing the pathophysiological consequences of preeclampsia with severe features and eclampsia. Read More

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September 2018
1 Read

The advertisement call of Centrolene notostictum (Anura, Centrolenidae) with a new record of geographic distribution in Tolima, Colombia.

Zootaxa 2018 Feb 5;4377(4):575-576. Epub 2018 Feb 5.

Grupo de Herpetología, Eco-Fisiología & Etología. Departamento de Biología. Universidad del Tolima. 730006299, Ibagué, Colombia.

Centrolene notostictum Ruiz-Carranza Lynch,1991 is a glassfrog known from the Cordillera Oriental of Colombia-in the Departments of Boyacá, Cundinamarca, Norte de Santander and Santander (Frost 2017)-and the Venezuelan versant of the Sierra de Perijá (Rojas et al. 2012) from 1600 to 2440 masl. Although males have been found calling on the upper surface of the leaves of ferns and Heliconeaceae on the margins of a small fast-flowing stream (Rojas et al. Read More

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February 2018

A new species of Hyloscirtus (Anura, Hylidae) from the Colombian and Venezuelan slopes of Sierra de Perijá, and the phylogenetic position of Hyloscirtus jahni (Rivero, 1961).

Zootaxa 2018 Feb 20;4382(1):121-146. Epub 2018 Feb 20.

Laboratório de Sistemática de Vertebrados, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Av. Ipiranga 6681, Porto Alegre, RS 90619-900, Brazil. Museo de Historia Natural La Salle, Fundación La Salle de Ciencias Naturales. Apartado Postal 1930, Caracas 1010-A, Venezuela..

A new species of Hyloscirtus, belonging to the H. bogotensis species Group, is described from the Venezuelan and Colombian slopes of the Sierra de Perijá. The new species can be readily distinguished from its congeners by the combination of the following characters: mental gland present, disc-shaped and small; ulnar, outer, and inner tarsal folds present; calcar tubercle absent; whitish stripes on external border of upper eyelids and supratympanic folds, longitudinally on the mid-dorsum, on supracloacal fold, outer ulnar folds, inner and outer tarsal folds, and also on dorsal internal surface of shanks. Read More

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February 2018

History of Mosquitoborne Diseases in the United States and Implications for New Pathogens.

Emerg Infect Dis 2018 05;24(5):821-826

The introduction and spread of West Nile virus and the recent introduction of chikungunya and Zika viruses into the Americas have raised concern about the potential for various tropical pathogens to become established in North America. A historical analysis of yellow fever and malaria incidences in the United States suggests that it is not merely a temperate climate that keeps these pathogens from becoming established. Instead, socioeconomic changes are the most likely explanation for why these pathogens essentially disappeared from the United States yet remain a problem in tropical areas. Read More

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May 2018
8 Reads

Alphaviruses: Serological Evidence of Human Infection in Paraguay (2012-2013).

Vector Borne Zoonotic Dis 2018 05 13;18(5):266-272. Epub 2018 Mar 13.

1 Research Institute in Health Sciences, National University of Asunción , San Lorenzo, Paraguay .

Introduction: Alphaviruses can produce febrile illness and encephalitis in dead-end hosts such as horses and humans. Within this genus, the Venezuelan Equine Encephalitis virus (VEEV) complex includes pathogenic epizootic subtypes and enzootic subtypes that are not pathogenic in horses (except subtype IE, Mexican strains), although they can cause febrile symptoms in humans. The Rio Negro virus (RNV-VEEV subtype VI) circulates in Argentina, where it was associated with undifferentiated febrile illness. Read More

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May 2018
6 Reads