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Sci Rep 2019 Feb 13;9(1):1994. Epub 2019 Feb 13.

Division of Nephrology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Lymphangiogenesis occurs in response to renal injury and is correlated with interstitial fibrosis. Diabetes- and high-fat diet (HFD)-induced intrarenal lipotoxicity and their relationships with lymphangiogenesis are not established. We used PPARα agonist, fenofibrate, to unravel the linkage between lipotoxicity and lymphangiogenesis. Read More

Biomed Res Int 2019 14;2019:2462561. Epub 2019 Jan 14.

Department of Biomedical Laboratory Science, Catholic Kwandong University, Gangneung, Republic of Korea.

Chronic prostatitis typically occurs in aging men, and its symptoms include frequent and painful urination. In recent study, several studies have shown that Korean red ginseng (KRG) can be used in the prevention and treatment of various diseases. The objective of this study is to investigate whether KRG can play a role in repressing the development of chronic nonbacterial prostatitis (CNP) in male Wistar rats. Read More

Artif Organs 2019 Feb 11. Epub 2019 Feb 11.

Department of Sports Medicine and Rehabilitation, St. Anne´s Faculty Hospital, Brno, Czech Republic.

There is ample evidence that maintenance of basic physical fitness through exercise training is crucial for patients with chronic renal insufficiency. Rehabilitation based on neuromuscular electrical stimulation (NMES) of thigh muscles has been shown to have many beneficial effects in patients with chronic diseases. It is likely that NMES could have beneficial effects also in patients on chronic ambulatory peritoneal dialysis (CAPD). Read More

Eur J Prev Cardiol 2019 Feb 10:2047487318825350. Epub 2019 Feb 10.

1 European Society of Cardiology, Sophia Antipolis, France.

Aims: The aim of this study was to determine whether the Joint European Societies guidelines on secondary cardiovascular prevention are followed in everyday practice.

Design: A cross-sectional ESC-EORP survey (EUROASPIRE V) at 131 centres in 81 regions in 27 countries.

Methods: Patients (<80 years old) with verified coronary artery events or interventions were interviewed and examined ≥6 months later. Read More

Vopr Kurortol Fizioter Lech Fiz Kult 2019 ;96(1):50-54

Research Institute of Complex Problems of Cardio-Vascular Diseases, Kemerovo, Russia.

The ever increasing number of the patients presenting with the cardio-surgical problems referred for surgery emphasizes the importance of the treatment of the cases of post-operative complications based on the personalized approach. The present article was designed to report a clinical case of the successful surgical treatment and rehabilitation of a patient presenting with the dysfunction of the bioprosthetic mitral valve and complications of the post-operative course in the form of polyorgan insufficiency with the predominance of respiratory failure. Special attention is given to the post-operative complications among which the respiratory insufficiency prevailed that made necessary the long period of artificial pulmonary ventilation. Read More

J Infect Dis 2019 Jan 29. Epub 2019 Jan 29.

Center for AIDS Research, Case Western Reserve University/University Hospitals, Cleveland, Ohio.

Circulating CD8+ T cells and monocytes are activated during HIV infection and co-localize in the aortas of SIV-infected non-human primates. We hypothesized that CD8+ T cells could exert a pro-atherosclerotic effect via paracrine actions on monocytes. We find that T cell receptor (TCR)-stimulated CD8+ T cells induce monocytes to express tissue factor (TF), a potent activator of coagulation. Read More

Medicine (Baltimore) 2019 Jan;98(3):e14049

Department of Cardiology, Second Affiliated Hospital of Guangzhou Univ Chinese Med (Guangdong Provincial Hospital of Chinese Medicine), China.

Background: Several studies have reported the benefits of traditional Chinese exercises (TCEs) on hypertension; however, a consensus regarding the effectiveness and safety of TCEs for patients with hypertension has not been reached.

Methods And Results: Only randomized controlled trials were included in our study. A total of 16 articles involving 1164 patients with hypertension met the inclusion criteria. Read More

Kardiochir Torakochirurgia Pol 2018 Dec 31;15(4):233-237. Epub 2018 Dec 31.

Department of Cardiac, Vascular and Endovascular Surgery and Transplantology in Zabrze, Medical University of Silesia in Katowice, Silesian Center for Heart Diseases, Poland.

Introduction: Sternum closure techniques have been compared regarding biomechanics, efficacy in high-risk patients and prevention of mediastinitis or sternal dehiscence. There are no papers concerning patients' comfort and postoperative rehabilitation rate.

Aim: To establish the best surgical closure technique after midline sternotomy regarding the lowest pain level in the postoperative period and the highest rate of postoperative rehabilitation. Read More

Alzheimers Dement 2019 Jan;15(1):158-167

Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Alzheimer's Disease Research Center, Keck School of Medicine at the University of Southern California, Los Angeles, CA, USA. Electronic address:

Increasing evidence recognizes Alzheimer's disease (AD) as a multifactorial and heterogeneous disease with multiple contributors to its pathophysiology, including vascular dysfunction. The recently updated AD Research Framework put forth by the National Institute on Aging-Alzheimer's Association describes a biomarker-based pathologic definition of AD focused on amyloid, tau, and neuronal injury. In response to this article, here we first discussed evidence that vascular dysfunction is an important early event in AD pathophysiology. Read More

Health Qual Life Outcomes 2019 Jan 14;17(1):10. Epub 2019 Jan 14.

Department of Health Education & Promotion, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Cardiovascular diseases (CVD) as a most frequent and costly NCDs account for about 17.3 million annual deaths worldwide. About 80% of these deaths are taking place in low and middle income countries (LMIC). Read More

J Stroke Cerebrovasc Dis 2019 Feb 26;28(2):276-284. Epub 2018 Oct 26.

Extremadura University Medical School, Department of Medical-Surgery Therapeutics, Badajoz, Spain. Electronic address:

Background: Studies suggest that fatigue and cognitive impairment may be present after transient ischemic attack (TIA) or minor stroke, but little is known about consequences in daily life. The main aim was to explore the presence of fatigue, cognitive impairment, and consequences in daily life after minor stroke-TIA.

Methods: Patients (n = 92) were consecutively recruited from the Stroke Unit and were assessed within 2 weeks of hospital admission for first-ever and 3 months later. Read More

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2018 Oct;32(10):1241-1248

Department of Orthopaedics, Rehabilitation Hospital of the National Research Center for Rehabilitation Technical Aids, Beijing, 100176, P.R.China.

Objective: To analyze the data of external fixation instruments (including Ilizarov instruments) used by QIN Sihe orthopaedic surgical team in the treatment of limb deformities in the past 30 years, and to explore the indications for the application of modern external fixation techniques in the correction of limb deformities and individual device configuration selection strategy.

Methods: According to QIN Sihe orthopaedic surgical team, the use of external fixator between January 1988 and December 2017 was analyzed retrospectively. The total use of external fixation and the proportion of different external fixators were analyzed in gender, different operation time, different age, different parts, and different diseases. Read More

Indian Heart J 2018 Dec 18;70 Suppl 3:S82-S89. Epub 2018 Jul 18.

Centre for Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia (Central University), New Delhi, 110025, India.

Background: Cardiac autonomic neuropathy (CAN) is a commonly overlooked complication of Type 2 Diabetes Mellitus (T2DM) characterized by imbalance between sympathetic and parasympathetic supply to the heart. The susceptibility of heart to dysrhythmias and fatal events increases during and after exercise due to a shift in autonomic regulation. Diabetes and hypertension (HTN) frequently occur concurrently and both conditions lead to impaired cardiac autonomic control. Read More

Indian Heart J 2018 Dec 19;70 Suppl 3:S4-S7. Epub 2018 Jan 19.

Department of Medical Surgical Nursing, Social Determinants of Health Research Center, School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran; Department of Nursing, Faculty of Nursing and Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Electronic address:

Background: Coronary artery bypass grafting surgery (CABG) is a common treatment for coronary artery disease. The patient's commitment to modify risk factors is necessary to achieve the desired after surgery outcomes. The current study aimed at determining illness perception of patients after CABG, its relation to smoking cessation, and detecting other predictors of smoking cessation. Read More

Indian Heart J 2018 Dec 7;70 Suppl 3:S28-S35. Epub 2018 Apr 7.

Centre for Physiotherapy and Rehabilitation Sciences, Jamia Millia Islamia (A Central University), New Delhi, 110025, India. Electronic address:

Objective: To investigate the effect of combined aerobic and resistance training (CART) on heart rate variability in sedentary, hypertensive women.

Participants: A total of twenty-eight hypertensive (Stage 1 and 2) sedentary women (Age 40.54 ± 4. Read More

Medicine (Baltimore) 2018 Dec;97(52):e13968

Department of Rehabilitation Medicine, Daegu Fatima Hospital, Daegu, Republic of Korea.

Although stroke is one of the most common causes of dysphagia, no studies have investigated the radionuclide salivagram as a predictor of aspiration pneumonia in patients with stroke. In addition, few researches on the risk factors of aspiration pneumonia in patients with subacute and chronic stroke undergoing rehabilitation in the rehabilitation unit have been rarely conducted. In this study, therefore, we investigated whether a radionuclide salivagram could predict aspiration pneumonia, and tried to find other clinical factors that may be helpful in predicting aspiration pneumonia in stroke patients undergoing rehabilitation in the rehabilitation department. Read More

Medicine (Baltimore) 2018 Dec;97(52):e13702

Department of Neurology, The First People's Hospital of Xianyang City, Xianyang, China.

Background: This study aimed to evaluate the effectiveness of neuromuscular electrical stimulation (NMES) therapy in patients with urinary incontinence after stroke (UIAS).

Methods: A total of 82 patients with UIAS were randomly assigned to 2 groups that received NMES therapy (NMES group) or sham NMES (sham group) for 10 weeks. The primary efficacy endpoints were measured by urodynamic values, and Overactive Bladder Symptom Score (OABSS). Read More

Clin Interv Aging 2019 19;14:9-16. Epub 2018 Dec 19.

University of Sherbrooke, School of Medicine and Health Sciences, School of Rehabilitation, Research Center on Aging, Sherbrooke, Québec, Canada,

Purpose: Intensity of a training program is a critical variable in treatment gains poststroke, but there are no guidelines to adequately dose the intensity of functional training (FT); the recommended type of training to promote poststroke recovery. Such guidelines are made available for strength training (ST) using the 1 repetition maximum (1RM), which has been linked to individuals' self-rated level of exertion using the Borg rating of perceived exertion (BRPE) scale. The BRPE could be a valuable tool for clinicians to dose FT intensity after a stroke, but this remains to be tested. Read More

Circulation 2019 Jan;139(5):620-635

Department of Epidemiology, (A.P.R., B.M.P., N.L.S.), University of Washington, Seattle.

Background: Factor VIII (FVIII) and its carrier protein von Willebrand factor (VWF) are associated with risk of arterial and venous thrombosis and with hemorrhagic disorders. We aimed to identify and functionally test novel genetic associations regulating plasma FVIII and VWF.

Methods: We meta-analyzed genome-wide association results from 46 354 individuals of European, African, East Asian, and Hispanic ancestry. Read More

Neurologist 2019 Jan;24(1):10-12

Department of Neurology, Medical University of South Carolina, Charleston, SC.

Background: Analyses from the Stenting and Aggressive Medical management for prevention of Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) trial showed that good control of vascular risk factors (systolic blood pressure, low-density lipoprotein, and exercise) was associated with fewer vascular events and exercise had the biggest impact on the outcome. We sought to determine the type and duration of exercise performed by SAMMPRIS patients during the trial.

Methods: SAMMPRIS aggressive medical management included a telephonic lifestyle modification program, INTERVENT, that was provided free of charge to all subjects during the study. Read More

Int J Cardiol 2018 Dec 16. Epub 2018 Dec 16.

Department of Cardiovascular Sciences, KU Leuven, Belgium; Department of Cardiovascular Diseases, University Hospitals Leuven, Belgium. Electronic address:

Background: The long-term evolution of pulmonary vascular resistance (PVR) after ventricular septal defect (VSD) repair is unknown. This study serially evaluated resting and exercise PVR after VSD repair in childhood.

Methods: Patients were enrolled from the outpatient Adult Congenital Heart Disease clinic of the University Hospitals Leuven and compared to age- and gender-matched controls. Read More

Indian Heart J 2018 Nov - Dec;70(6):783-787. Epub 2017 Dec 16.

Department of Cardiovascular Research, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Community Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Background: Depression is a common condition in cardiac patients. We investigated the effect of cardiac rehabilitation on depressive symptoms as detected by Beck depression inventory II score (BDI) in patients who underwent percutaneous coronary intervention (PCI).

Methods: In this cohort, 95 patients met our criteria. Read More

Indian Heart J 2018 Nov - Dec;70(6):777-782. Epub 2018 Jan 9.

Maharishi Markandeshwar Institute of Physiotherapy and Rehabilitation, Maharishi Markandeshwar University, Mullana, Ambala, Haryana, 133207, India.

Objective: To determine the pattern of physical activity specific to age and gender among young Indian school going girls and boys aged 8-14 years.

Design: Cross-sectional study.

Setting: Private and government sponsored schools in Patiala and Mansa District of Punjab, India. Read More

Arch Med Res 2018 Dec 19. Epub 2018 Dec 19.

Dirección de Prestaciones Médicas, Instituto Mexicano del Seguro Social, Ciudad de México, México.

The cardiovascular diseases (CVDs) have a growing impact over the world mortality, affecting mostly low and middle-income countries. This is due to changes in the population pyramid and the increase in unhealthy lifestyles that predispose the global population to cardiovascular risk factors such as overweight, obesity, smoking, hypertension, diabetes, dyslipidemias and metabolic syndrome. Ischemic heart disease and the cerebral vascular event remain the first causes of death reported by the World Health Organization (WHO) for more than a decade. Read More

Eur Respir J 2018 Dec 21. Epub 2018 Dec 21.

Scottish Pulmonary Vascular Unit, Golden Jubilee National Hospital, Glasgow, United Kingdom.

Objectives of this ERS Task Force were to summarise current studies, to develop strategies for future research and to increase availability and awareness of exercise training for pulmonary hypertension (PH) patients.An evidence-based approach with clinical expertise of the Task Force members, based on both literature search and face-to-face meetings was conducted. The statement summarises current knowledge and open questions regarding clinical effects of exercise training in PH, training modalities, implementation strategies and pathophysiologic mechanisms. Read More

Medicine (Baltimore) 2018 Dec;97(51):e13451

Department of Neurology, First Affiliated Hospital of Chinese PLA General Hospital, Beijing, China.

Rationale: Left atrial myxoma is a common primary cardiac tumor, however, due to poor image quality or atypical myxoma images, it is often misdiagnosed by echocardiograph. A case of left atrial myxoma being misdiagnosed as a thrombus, which successively caused acute myocardial infarction (AMI) and stroke, is very rare. Contrast-enhanced echocardiography can play an important role in definitive diagnosis. Read More

Nutrients 2018 Dec 17;10(12). Epub 2018 Dec 17.

Department of Medicine & Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.

Recent studies have noted an association between chewing difficulties and frailty. In a pilot survey of primary care needs of older people living in the community using automated methods, we examined the prevalence of chewing difficulties and the cross-sectional association with other geriatric syndromes, chronic diseases, and the use of hospital services. A brief multi-domain geriatric assessment was administered to 2259 men and women using a mobile device, the data uploaded to the cloud and analyzed. Read More

Eur Heart J 2019 Jan;40(1):19-33

Cardiology Clinical Academic Group, St George's, University of London, London, UK.

Myocardial diseases are associated with an increased risk of potentially fatal cardiac arrhythmias and sudden cardiac death/cardiac arrest during exercise, including hypertrophic cardiomyopathy, dilated cardiomyopathy, left ventricular non-compaction, arrhythmogenic cardiomyopathy, and myo-pericarditis. Practicing cardiologists and sport physicians are required to identify high-risk individuals harbouring these cardiac diseases in a timely fashion in the setting of preparticipation screening or medical consultation and provide appropriate advice regarding the participation in competitive sport activities and/or regular exercise programmes. Many asymptomatic (or mildly symptomatic) patients with cardiomyopathies aspire to participate in leisure-time and amateur sport activities to take advantage of the multiple benefits of a physically active lifestyle. Read More

Neurorehabil Neural Repair 2018 12;32(12):1011-1019

1 University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Background: The residual hemiparesis after stroke results in a unilateral reduction in propulsive force during gait. Prior work has suggested the presence of a propulsive reserve in the paretic limb.

Objective: The purpose of this study was to quantify the paretic propulsive reserve in individuals poststroke and to determine the biomechanical mechanism underlying the generation of additional paretic propulsive limb force. Read More

Medicine (Baltimore) 2018 Dec;97(50):e13533

Department of Physical Medicine and Rehabilitation.

Rationale: Recent studies have used diffusion tensor tractography (DTT) to demonstrate that central poststroke pain (CPSP) was related to spinothalamic tract (STT) injury in patients with stroke. However, few studies have been reported about delayed-onset CPSP due to degeneration of the STT following a stroke.

Patient's Concerns: A 57-year-old female patient presented with right hemiparesis after stroke. Read More

Medicine (Baltimore) 2018 Dec;97(50):e13401

Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daegu, Republic of Korea.

Rationale: A few studies using diffusion tensor tractography (DTT) have demonstrated recovery of injured corticoreticulospinal tract (CRT) in patients with intracerebral hemorrhage and infarct. However, no study reported on a patient who showed peri-infarct reorganization of an injured CRT following a middle cerebral artery territory infarct.

Patient Concerns: A 56-year-old right-handed male patient was diagnosed as spontaneous subarachnoid hemorrhage (SAH) and intraventricular hemorrhage (IVH) and underwent clipping for a ruptured anterior communicating artery aneurysm and right frontal extraventricular drainage for IVH at the department of neurosurgery of a university hospital. Read More

J Am Coll Cardiol 2018 Dec;72(23 Pt B):3053-3070

Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute Ochsner Clinical School-The University of Queensland School of Medicine, New Orleans, Louisiana.

Physical inactivity is one of the leading modifiable risk factors for global mortality, with an estimated 20% to 30% increased risk of death compared with those who are physically active. The "behavior" of physical activity (PA) is multifactorial, including social, environmental, psychological, and genetic factors. Abundant scientific evidence has demonstrated that physically active people of all age groups and ethnicities have higher levels of cardiorespiratory fitness, health, and wellness, and a lower risk for developing several chronic medical illnesses, including cardiovascular disease, compared with those who are physically inactive. Read More

J Stroke Cerebrovasc Dis 2019 Jan 24;28(1):191-197. Epub 2018 Oct 24.

Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences (ICES), Toronto, Ontario, Canada; Department of Medicine, Division of General Internal Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Objective: To determine predictors of direct enteral tube (DET) placement after acute stroke.

Methods: We used the Ontario Stroke Registry to identify patients who received direct enteral tubes (gastrostomy or jejunostomy) during hospital stay after acute ischemic stroke or intracerebral hemorrhage from July 1, 2003 to March 31, 2013. We used multivariable logistic regression to identify predictors of receiving DET after stroke. Read More

Pharmacol Ther 2018 Dec 6. Epub 2018 Dec 6.

Laboratory of Cellular and Molecular Pathology, IRCCS San Raffaele Pisana, Rome, Italy; San Raffaele Open University, Rome, Italy. Electronic address:

High-mobility group box 1 (HMGB1) is one of the most abundant proteins in eukaryotes and the best characterized damage-associated molecular pattern (DAMP). The biological activities of HMGB1 depend on its subcellular location, context and post-translational modifications. Inside the nucleus, HMGB1 is engaged in many DNA events such as DNA repair, transcription regulation and genome stability; in the cytoplasm, its main function is to regulate the autophagic flux while in the extracellular environment, it possesses more complicated functions and it is involved in a large variety of different processes such as inflammation, migration, invasion, proliferation, differentiation and tissue regeneration. Read More

Lipids Health Dis 2018 Dec 8;17(1):279. Epub 2018 Dec 8.

Department of Cardiology, Affiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Dalian, China.

Background: Hyperlipidemia is a well-established risk factor for cardiac damage, which can lead to cardiovascular diseases. Many studies have shown that Coenzyme Q10(CoQ10) protects against cardiac damage in vivo. The aim of this study was to investigate the possible protective effects of CoQ10 against cardiac damage in apolipoprotein E-deficient (ApoE) mice. Read More

BMC Neurol 2018 Dec 7;18(1):202. Epub 2018 Dec 7.

Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.

Background: Cerebrospinal fluid (CSF) biomarkers reflect ongoing processes in the brain. Growth-associated protein 43 (GAP-43) is highly upregulated in brain tissue shortly after experimental ischemia suggesting the CSF GAP-43 concentration may be altered in ischemic brain disorders. CSF GAP-43 concentration is elevated in Alzheimer's disease patients; however, patients suffering from stroke have not been studied previously. Read More

Med Sci Monit Basic Res 2018 Dec 3;24:210-215. Epub 2018 Dec 3.

School of Laboratory Medicine, Wannan Medical College, Wuhu, Anhui, China (mainland).

BACKGROUND Tai Chi is an ancient form of physical activity that has been shown to improve cardiovascular function, but to date there had been no comprehensive systematic review on the effect of Tai Chi exercise on balance function of patients with stroke. This study evaluated the effect of Tai Chi exercise on balance function in stroke patients. MATERIAL AND METHODS PubMed, Cochrane library, and China National Knowledge Information databases and the Wan Fang medical network were searched to collect the articles. Read More

J Stroke Cerebrovasc Dis 2019 Feb 30;28(2):499-512. Epub 2018 Nov 30.

Rijnlands Rehabilitation Centre, Leiden, The Netherlands; Sophia Rehabilitation Centre, The Hague, The Netherlands; Department of Orthopaedics, Leiden University Medical Center, Rehabilitation, and Physical Therapy, Leiden, The Netherlands.

Purpose: Structured application of patient-reported outcome measures (PROMs) is a key element in Value Based Healthcare. This study aimed to evaluate the feasibility of a broad set of PROMs reflecting similar patient reported health domains as proposed within the International Standard Set of Patient-Centered Outcome Measures After Stroke within the first year after stroke.

Methods: The study included consecutive stroke patients admitted to inpatient or outpatient specialized rehabilitation. Read More

Turk Kardiyol Dern Ars 2018 12;46(8):683-691

Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Objective: It has been reported that women receive fewer preventive recommendations regarding pharmacological treatment, lifestyle modifications, and cardiac rehabilitation compared with men who have a similar risk profile. This study was an investigation of the impact of gender on cardiovascular risk profile and secondary prevention measures for coronary artery disease (CAD) in the Turkish population.

Methods: Statistical analyses were based on the European Action on Secondary and Primary Prevention through Intervention to Reduce Events (EUROASPIRE)-IV cross-sectional survey data obtained from 17 centers in Turkey. Read More

Int J Mol Sci 2018 Nov 30;19(12). Epub 2018 Nov 30.

Department of Human and Animal Physiology, Saratov State University, Astrakhanskaya Str. 83, 410012 Saratov, Russia.

The peripheral lymphatic system plays a crucial role in the recovery mechanisms after many pathological changes, such as infection, trauma, vascular, or metabolic diseases. The lymphatic clearance of different tissues from waste products, viruses, bacteria, and toxic proteins significantly contributes to the correspondent recovery processes. However, understanding of the cerebral lymphatic functions is a challenging problem. Read More

Medicine (Baltimore) 2018 Nov;97(48):e13414

Department of Rehabilitation Medicine, Kyungpook National University Chilgok Hospital, School of Medicine, Kyungpook National University.

Rationale: Spontaneous intramedullary spinal cord hemorrhage (hematomyelia) is a rare disease and most cases have specific etiologies such as cavernous malformations and tumor. Most reported cases are about surgical treatment of intramedullary spinal cord hemorrhage, but there are no reports of rehabilitation effectiveness reported. This case reports the first case with positive effect of rehabilitation on a patient with intramedullary spinal cord hemorrhage, who did not undergo surgery. Read More

Medicine (Baltimore) 2018 Nov;97(48):e13387

Department of Physical Medicine and Rehabilitation, The First Hospital of Jilin University, Changchun, Jilin, China.

Motor dysfunction is a common and severe complication of stroke that affects the quality of life of these patients. Currently, motor function rehabilitation predominantly focuses on active movement training; nevertheless, the role of sensory input is usually overlooked. Sensory input is very important to motor function. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2018 ;118(10):97-107

Federal State Autonomous Institution 'National Medical Research Center for Neurosurgery named after Academician N.N. Burdenko' of the Ministry of Health of the Russian Federation, Moscow, Russia.

Antihypoxic, antioxidant and nootropic effects of mexidol contribute to the improvement of patients with cerebrovascular pathology. The results of clinical studies show that the sequential scheme of using mexidol (first i.v. Read More

World J Gastroenterol 2018 Nov;24(42):4750-4758

Gastroenterology center, Nanto Municipal Hospital, Toyama 932-0221, Japan.

Gut microbiota are involved in the development or prevention of various diseases such as type 2 diabetes, fatty liver, and malignancy such as colorectal cancer, breast cancer and hepatocellular carcinoma. Alzheimer's disease, osteoporosis, sarcopenia, atherosclerotic stroke and cardiovascular disease are major diseases associated with decreased activities of daily living (ADL), especially in elderly people. Recent analyses have revealed the importance of gut microbiota in the control of these diseases. Read More

Work 2018 ;61(4):523-535

Department of Physiotherapy, University School of Physical Education, Wroclaw, Poland.

Background: A large proportion of individuals with a stroke are unable to return to work, although figures vary greatly. Due to the very high cost of post-stroke care, both tangible and intangible, in the form of long-term social consequences, it seems extremely important to search for factors responsible for the low efficiency of the rehabilitation and recovery process, because this fact has direct influence on future employment. Such knowledge would enable physiotherapists to quickly identify those patients who are at risk of rehabilitation breakdown, in order to provide them with special care and include them in intensive therapeutic treatments. Read More

Life Sci 2019 Jan 22;216:176-182. Epub 2018 Nov 22.

Department of Children Rehabilitation, Jining No.1 People's Hospital, Jining 272011, China; Jining No.1 People's Hospital of Jining Medical University, Jining Medical University, Jining 272000, China. Electronic address:

Aims: Hypoxic-ischemic encephalopathy (HIE) is a common brain injury disease in neonates, which can lead to neonatal disability and death. Geniposide (GEN) is a main ingredient of Gardenia jasminoides, whose anti-tumor, anti-inflammatory and anti-apoptotic effects have been reported in various diseases. However, the effect of GEN on HIE remains uninvestigated. Read More

J Stroke Cerebrovasc Dis 2019 Feb 19;28(2):513-520. Epub 2018 Nov 19.

Sarah Network Rehabilitation Hospitals, Belo Horizonte, Minas Gerais, Brazil. Electronic address:

Background And Purpose: The aim of this study was to evaluate heterotopic ossification (HO) prevalence after stroke, describing clinical features and investigating predictors of HO and its severity.

Methods: A cross-sectional study was carried out in 7 rehabilitation centers (Sarah Network) from 2004 to 2013.

Results: Among 17,794 stroke cases, 235 patients (1. Read More

Clin Sports Med 2019 Jan;38(1):61-78

Department of Biomedical Sciences, Humanitas University, Via Manzoni 113, Rozzano, Milan 20089, Italy; Humanitas Clinical and Research Center, Via Manzoni 56, Rozzano, Milan 20089, Italy.

This article analyzes the current literature on the use of adipose-derived stem cells (ASCs) to evaluate the available evidence regarding their therapeutic potential in the treatment of cartilage pathology. Seventeen articles were included and analyzed, showing that there is overall a lack of high-quality evidence concerning the use of ASCs. Most trials are case series with short-term evaluation. Read More

BMC Health Serv Res 2018 Nov 22;18(1):881. Epub 2018 Nov 22.

Saw Swee Hock School of Public Health, National University of Singapore, 12 Science Drive 2, #10-01, Singapore, 117549, Singapore.

Background: It is essential to study post-stroke healthcare utilization trajectories from a stroke patient caregiver dyadic perspective to improve healthcare delivery, practices and eventually improve long-term outcomes for stroke patients. However, literature addressing this area is currently limited. Addressing this gap, our study described the trajectory of healthcare service utilization by stroke patients and associated costs over 1-year post-stroke and examined the association with caregiver identity and clinical stroke factors. Read More

Int Heart J 2019 Jan 20;60(1):208-214. Epub 2018 Nov 20.

Department of Cardiology, Showa University Fujigaoka Hospital.

Anderson-Fabry disease is a rare X-linked lysosomal storage disease caused by α-galactosidase A (α-GalA) gene variants and characterized by a large genotypic and phenotypic spectrum. Enzyme replacement therapy (ERT) using recombinant α-GalA has been approved for > 10 years as a specific therapy for the disease. However, the long-term clinical efficacy for cardiac manifestations has been equivocal because it depends on several factors such as genotype, sex, age, and disease severity at the initiation of ERT. Read More