Search Our Scientific Publications & Authors

J Vasc Surg Venous Lymphat Disord 2020 May 20. Epub 2020 May 20.

Cardiovascular Center, Tufts Medical Center, Tufts University School of Medicine, Boston, Mass.

Objective: Lymphedema (LED) affects an estimated 35 million patients in the United States and a staggering 140,200 million people worldwide, yet LED is the forgotten vascular disease. Whereas the diagnosis and treatment of arterial and venous diseases have been strengthened by the development of clinical practice guidelines (CPGs), few CPGs are available for LED. Moreover, for CPGs to have their greatest impact, they should be both of high quality and developed using the most rigorous evidence-based methods. Read More

Semin Musculoskelet Radiol 2020 Apr 21;24(2):156-166. Epub 2020 May 21.

Department of Radiology, Division of Rheumatology and Sports Imaging, Medical University Innsbruck, Innsbruck, Austria.

Ultrasound elastography (USE) is becoming an important adjunct tool in the evaluation of various musculoskeletal (MSK) traumatic conditions and diseases, with an increasing number of applications and publications in recent years. This rapidly evolving technique enhances the conventional ultrasound (US) examination by providing information on the elastic properties of tissue alongside the morphological and vascular information obtained from B-mode US and Doppler imaging. Those performing USE must have basic knowledge of its proper imaging techniques and limitations. Read More

Monaldi Arch Chest Dis 2020 May 20;90(2). Epub 2020 May 20.

Fondazione Umbra Cuore e Ipertensione ONLUS and Division of Cardiology, Hospital S. Maria della Misericordia, Perugia.

The novel respiratory Syndrome Coronavirus-2 (SARS-CoV-2) caused a cluster of pneumonia cases in China at the end of 2019. After few months, it led to a pandemic that has spread throughout most countries of the world (https://coronavirus.jhu. Read More

Cureus 2020 Apr 17;12(4):e7715. Epub 2020 Apr 17.

Emergency Medicine, Envision Physician Services, Nashville, USA.

Aneurysmal ruptures are a life-threatening pathology, and while the aorta is the principal location, any aneurysmal rupture can be fatal. Most result from chronic diseases, such as hypertension, diabetes, and vasculitis. Nevertheless, a rupture can result in acute decompensation and must be recognized and addressed quickly to limit morbidity and mortality. Read More

Diagnostics (Basel) 2020 May 16;10(5). Epub 2020 May 16.

Unit of Vascular and Endovascular Surgery; University Hospital of Ferrara. Via Aldo Moro 8, 44124 Ferrara, Italy.

We assessed whether muscle metabolism biomarkers (MMb) identified by near-infrared spectroscopy (NIRS) are valid for determining adaptations following revascularization or exercise training in peripheral artery disease (PAD). Eighteen patients (males = 13; 69 ± 7 years) were randomized to receive revascularization (Rev = 6) or pain-free home-based exercise (Ex = 12). MMb were safely collected via a NIRS-assisted treadmill test as area-under-curve for the spectra of oxygenated (-oxy), deoxygenated (-deoxy), differential (-diff) and total (-tot) hemoglobin traces. Read More

Respiration 2020 May 19:1-7. Epub 2020 May 19.

Respiratory Rehabilitation of the Institute of Montescano, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy.

Due to the exponential growth of the number of subjects affected by coronavirus disease 2019 (COVID-19), the entire Italian health care system had to respond promptly and in a very short time with the need of semi-intensive and intensive care units. Moreover, trained dedicated COVID-19 teams consisting of physicians were coming from different specialties (intensivists or pneumologists and infectiologists), while respiratory therapists and nurses have been recruited to work on and on without rest. However, due to still limited and evolving knowledge of COVID-19, there are few recommendations concerning the need in respiratory rehabilitation and physiotherapy interventions. Read More

BMC Health Serv Res 2020 May 14;20(1):422. Epub 2020 May 14.

Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), Postbox 8905, 7491, Trondheim, Norway.

An amendment to this paper has been published and can be accessed via the original article. Read More

Drugs Today (Barc) 2020 May;56(5):311-320

University Eye Clinic of Genoa, IRCCS Ospedale Policlinico San Martino, Genoa, Italy; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genoa, Italy; Macula Onlus Foundation, Genoa, Italy.

Wet age-related macular degeneration (w-AMD) represents the main cause of vision loss in the elderly in the western countries. The important role displayed by vascular endothelial growth factor (VEGF) in the pathogenesis of this disease has been largely demonstrated. For this reason, anti-VEGF drugs have been developed and currently are considered as the first-line treatment options in the management of w-AMD. Read More

Monaldi Arch Chest Dis 2020 May 14;90(2). Epub 2020 May 14.

Department of Cardiac-Thoracic-Vascular Diseases, Cardiac Surgery and Transplantation, St. Orsola University Hospital, Bologna.

Postoperative rehabilitation is a cornerstone of the recovery pathway following left ventricular assist device implantation (LVAD), and patients are expected to conduct an autonomous life thanks to improved technology and increased knowledge of mechanical circulatory support. The primary purpose of the present study was to quantify clinical changes related to rehabilitation, in patients with LVAD: functional capacity, disability, and quality of life were identified as reliable outcomes to detect such changes. The current study was a scoping review conducted searching three primary databases, namely PubMed, Scopus, and Cochrane Library, from their inception until January 2020. Read More

J Alzheimers Dis 2020 May 7. Epub 2020 May 7.

Department of Internal Medicine and Medical Specialties, DIMI, Section of Geriatrics, Genoa, Italy.

Dementia is an age-related clinical condition, with higher incidence rates in older ages. However, there is some evidence that a reverse epidemiology is also observed. Namely, the cohort analysis of dementia incidence rates by birth in selected populations demonstrated a decreased incidence of dementia in late life across the last twenty years, possibly due to decreased incidence of cardiovascular disorders and increased education and cognitive reserve. Read More

Ophthalmologe 2020 May 8. Epub 2020 May 8.

Campus Kiel, Klinik für Augenheilkunde, Universitätsklinikum Schleswig-Holstein, Kiel, Deutschland.

In the case of acute vitreous body hemorrhage, the ophthalmologist is faced with the question of whether spontaneous absorption can be awaited or whether a vitrectomy is necessary. In addition to the intensity of the bleeding, the underlying cause also plays an important role. A thorough medical history is therefore important. Read More

Medicine (Baltimore) 2020 May;99(19):e19992

Department of Cardiology, Nagoya City University Graduate School of Medical Sciences.

The high-sensitivity cardiac troponin I (hs-cTnI) in serum can increase due to an increase in left ventricular (LV) overload in individuals with hypertension. Since LV voltage on an electrocardiogram (ECG) reflects LV load, it is possible that LV voltage is closely associated with hs-cTnI in individuals without hypertension. This study investigated the association between LV voltage indices and serum hs-cTnI levels in normotensive Japanese individuals. Read More

Adv Healthc Mater 2020 May 6:e2000255. Epub 2020 May 6.

Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, P. R. China.

Extracellular vesicles (EVs) are a heterogeneous group of membranous structures, which can be secreted by most cell types. As a product of paracrine secretion, EVs are considered to be a regulatory mediator for intercellular communication. There are many bioactive cargos in EVs, such as proteins, lipids, and nucleic acids. Read More

Neurol Sci 2020 May 6. Epub 2020 May 6.

Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan 2nd Road, Guangzhou, 510080, Guangdong Province, China.

Purpose: The clinical significance of FLAIR vascular hyperintensity (FVH), a marker of collateral circulation in ischaemic stroke, remains controversial. We hypothesised that the association between FVH and outcomes varies with the severity of leukoaraiosis (LA), another marker of collaterals, and that their combined significance may vary with time.

Methods: We included 459 consecutive patients with middle cerebral artery (MCA) stroke. Read More

Mayo Clin Proc 2020 May;95(5):955-965

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts General Hospital, Boston.

Objective: To determine whether brain volume is associated with functional outcome after acute ischemic stroke (AIS).

Patients And Methods: This study was conducted between July 1, 2014, and March 16, 2019. We analyzed cross-sectional data of the multisite, international hospital-based MRI-Genetics Interface Exploration study with clinical brain magnetic resonance imaging obtained on admission for index stroke and functional outcome assessment. Read More

J Cardiopulm Rehabil Prev 2020 May;40(3):131-137

Beaumont Health, Preventive Cardiology and Cardiac Rehabilitation, Oakland University William Beaumont School of Medicine, Royal Oak, Michigan (Dr Franklin); Departments of Health and Exercise Science, Wake Forest University, Winston-Salem, North Carolina (Dr Brubaker); Clinical Exercise Physiology Program, Ball State University, Muncie, Indiana (Dr Harber); Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School, The University of Queensland School of Medicine, New Orleans, Louisiana (Dr Lavie); VA Palo Alto Health Care System, Cardiology, Stanford University, Palo Alto, California (Dr Myers); and Fisher Institute of Health and Well-Being, Ball State University, Muncie, Indiana (Dr Kaminsky).

Risk to individuals for cardiovascular events are invariably tied to their exposure to major coronary risk factors. This risk can be substantially mitigated by lifestyle behaviors. This first part of this Commentary focuses on the important role both adopting healthful dietary patterns and regularly obtaining adequate physical activity have as preventative therapies for cardiovascular diseases. Read More

J Physiol 2020 Apr 29. Epub 2020 Apr 29.

Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, UK.

The increasing number of older adults has seen a corresponding growth in those affected by neurovascular diseases, including stroke and dementia. Since cures are currently unavailable, major efforts in improving brain health need to focus on prevention, with emphasis on modifiable risk factors such as promoting physical activity. Moderate-intensity continuous training (MICT) paradigms have been shown to confer vascular benefits translating into improved musculoskeletal, cardiopulmonary and cerebrovascular function. Read More

Can J Cardiol 2020 Apr 25. Epub 2020 Apr 25.

Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School-The University of Queensland School of Medicine, New Orleans, Louisiana, USA.

Am J Med 2020 Apr 25. Epub 2020 Apr 25.

Department of Physical Therapy, College of Applied Health Sciences, University of Illinois at Chicago, Chicago, IL, USA.

The 2019-2020 coronavirus pandemic elucidated how a single highly infectious virus can overburden healthcare systems of even highly economically developed nations. A leading contributor to these concerning outcomes is a lack of available intensive care unit (intensive care unit) beds and mechanical ventilation support. Poorer health is associated with a higher risk for severe respiratory complications from the coronavirus. Read More

Biomed Res Int 2020 6;2020:4574509. Epub 2020 Apr 6.

School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.

Chronic obstructive pulmonary disease (COPD) features chronic inflammatory reactions of both intra- and extrapulmonary nature. Moreover, COPD is associated with abnormal glucose and lipid metabolism in patients, which influences the prognosis and chronicity of this disease. Abnormal glucose and lipid metabolism are also closely related to inflammation processes. Read More

Medicine (Baltimore) 2020 Apr;99(17):e19911

Department of Exercise Rehabilitation Welfare, Soojung Campus, Sungshin Women's University, Seoul, Republic of Korea.

Marathon runners demonstrate a high incidence of coronary artery plaque; however, studies on runners with exercise-induced hypertension (EIH) are sparse. We aimed to investigate the prevalence of coronary artery plaque among marathon runners with EIH.Veteran male marathon runners (≥40 and <60 years) underwent an exercise stress test. Read More

Medicine (Baltimore) 2020 Apr;99(17):e19902

Gansu Provincial Hospital, Lanzhou, China.

Background: Aneurysmal subarachnoid hemorrhage (aSAH) is a disease caused by the infiltration of blood into the subarachnoid space due to the rupture of an intracranial aneurysm. It is a serious cerebrovascular disease, with a mortality rate of about 40% worldwide, which seriously threatens human life and health. Many drugs are used to treat aSAH and its complications, and some have been tested in systematic reviews and have shown good effects. Read More

Medicine (Baltimore) 2020 Apr;99(17):e19769

Institut d'investigació Sanitària Illes Balears.

Introduction: High blood pressure is the leading modifiable risk factor for cardiovascular disease, and is associated with high morbidity and mortality and with significant health care costs for individuals and society. However, fewer than half of the patients with hypertension receiving pharmacological treatment have adequate blood pressure control. The main reasons for this are therapeutic inertia, lack of adherence to treatment, and unhealthy lifestyle (i. Read More

Arthritis Res Ther 2020 Apr 23;22(1):90. Epub 2020 Apr 23.

Preventive Cardio-Rheuma clinic, Department of Rheumatology, Diakonhjemmet Hospital, PO Box 23, Vindern, N-01319, Oslo, Norway.

Background: In younger individuals, low absolute risk of cardiovascular disease (CVD) may conceal an increased risk age and relative risk of CVD. Calculation of risk age is proposed as an adjuvant to absolute CVD risk estimation in European guidelines. We aimed to compare the discriminative ability of available risk age models in prediction of CVD in rheumatoid arthritis (RA). Read More

BMC Cardiovasc Disord 2020 Apr 23;20(1):195. Epub 2020 Apr 23.

Department of Cardiovascular Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.

Background: Advanced glycation end products (AGEs) are associated with aging, diabetes mellitus (DM), and other chronic diseases. Recently, the accumulation of AGEs can be evaluated by skin autofluorescence (SAF). However, the relationship between SAF levels and exercise capacity in patients with cardiovascular disease (CVD) remains unclear. Read More

Medicine (Baltimore) 2020 Apr;99(16):e19835

Department of Physical Therapy, College of Health Sciences, Dankook University.

Rationale: Pusher syndrome is a disorder of postural control. It is associated with unilateral lesions on central vestibular system. In the current study, we attempted to identify and investigate neural connectivity of the parieto-insular vestibular cortex in a patient with pusher syndrome, using diffusion tensor imaging. Read More

Medicine (Baltimore) 2020 Apr;99(16):e19799

Department of Nutrition, the First Hospital of Shanxi Medical University.

Introduction: Wernicke's encephalopathy (WE) is a severe neuropsychiatric disorder, which results from a nutritional deficiency of thiamine. The occurrence of WE is rarely reported in patients with cerebral infarction, who often have complications of malnutrition. Cerebral infarction is a neurological disease, patients with cerebral infarction may show symptoms such as disturbance of consciousness and gait instability, which is difficult to differentiate from WE. Read More

Medicine (Baltimore) 2020 Apr;99(16):e19759

University of Medicine and Pharmacy 'Gr.T.Popa', Iasi, Romania.

Introduction: While the role of early mobilization in the immediate postinfarction period has been well demonstrated, little is known in present about the link between early mobilization and reduction of systemic inflammation. At the same time, the impact of early mobilization on regression of left ventricular remodeling has not been elucidated so far.

Material And Methods: Here we present the study protocol of the REHAB trial, a clinical descriptive, prospective study, conducted in a single-center, with the purpose to analyze the impact of early mobilization in reducing left ventricular remodeling, the complication rates and mortality in patients who had suffered a recent acute myocardial infarction (AMI). Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2020 ;120(3. Vyp. 2):49-53

Central City Clinical Hospital #6, Yekaterinburg, Russia.

Aim: To evaluate the efficacy of including cytoflavin in rehabilitation measures in the early recovery period of patients with ischemic stroke.

Material And Methods: Results of rehabilitation measures of 100 patients (50 women and 50 men, aged 18 to 85 years) in the early recovery period of ischemic stroke were analyzed. Psychological testing included NIHSS, MMSE, Rankin scale, Rivermead mobility index, exercise tolerance test. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2020 ;120(3. Vyp. 2):23-28

Research Center of Neurology, Moscow, Russia.

Over the past decade, non-invasive brain stimulation, in particular transcranial stimulation by direct electric current (TES), has been increasingly included in the array of methods used for rehabilitation of patients with post-stroke impairments (motor, speech, cognitive). Development of stimulation protocols with determination of the zones of exposure, as well as better understanding of the patterns of restoration of functional systems, became possible due to basic research using functional MRI paradigm. However, the complexity of the organization of the speech system, the variety of forms of aphasia that occur when it is damaged, the individual variability of neuroplastic processes, motivated a search for optimal stimulation protocols that contribute to the personification of the rehabilitation process. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2020 ;120(3. Vyp. 2):16-22

Vladimirsky Moscow Regional Scientific Research Clinical Institute, Moscow, Russia.

Cognitive impairment is common in poststroke patients. Today in rehabilitation programs the specialists use the vestibular stimulation including biological feedback to supporting reaction for treatment poststroke cognitive impairment. These studies show the relationship of vestibular function with memory, attention, spatial orientation, navigation, mental representation of three-dimensional space and other cognitive functions. Read More

Medicine (Baltimore) 2020 Apr;99(15):e19648

School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Background: Xingnaojing injection (XNJi) is widely used for acute cerebral hemorrhage. However, the efficacy of XNJi for acute cerebral hemorrhage has not been comprehensively proved by systematic analysis yet. Therefore, it is essential to evaluate the efficacy and safety of XNJi in an evidence-based method. Read More

Medicine (Baltimore) 2020 Apr;99(15):e19555

Department of Physical Medicine and Rehabilitation, Veterans Health Service Medical Center, Seoul, Republic of Korea.

To identify basic gait features and abnormal gait patterns that are common to different neurological or musculoskeletal conditions, such as cerebral stroke, Parkinsonian disorders, radiculopathy, and musculoskeletal pain.In this retrospective study, temporal-spatial, kinematic, and kinetic gait parameters were analyzed in 424 patients with hemiplegia after stroke, 205 patients with Parkinsonian disorders, 216 patients with radiculopathy, 167 patients with musculoskeletal pain, and 316 normal controls (total, 1328 subjects). We assessed differences according to the condition and used a community detection algorithm to identify subgroups within each condition. Read More

Curr Sports Med Rep 2020 Apr;19(4):133-136

Department of Kinesiology, University of Connecticut, Storrs, CT.

Adv Exp Med Biol 2020 Apr 8. Epub 2020 Apr 8.

Vita-Salute San Raffaele University and San Raffaele Scientific Institute, Milan, Italy.

Diabetes mellitus is constantly increasing worldwide. Vascular complications are the most common in the setting of long-standing disease, claiming the greatest burden in terms of morbidity and mortality. Glucotoxicity is involved in vascular damage through different metabolic pathways, such as production of advanced glycation end-products, activation of protein kinase C, polyol pathway activation and production of reactive oxygen species. Read More

Eur J Dermatol 2020 Feb;30(1):63-66

Department of Dermatology and Reference Center for Rare Diseases and Vascular Malformations (MAGEC), CHRU Tours, 37044 Tours Cedex 9, France, Universities of Tours and Nantes, INSERM 1246 - SPHERE, 37000 Tours, France.

Medicine (Baltimore) 2020 Apr;99(14):e19338

Department of Physical Medicine and Rehabilitation, Kyung Hee University College of Medicine, Seoul, Republic of Korea.

Introduction: A hiccup is myoclonus of a sudden involuntary contraction of the diaphragm. Hiccups have various causes, and brain stem stroke is one of the causes of central hiccups. Certain types of hiccups are caused by diseases that can be fatal. Read More

N Z Med J 2020 04 3;133(1512):88-92. Epub 2020 Apr 3.

Casey Hospital Emergency Department, Monash Health; Faculty of Medicine, Nursing and Health Sciences, Monash University.

Dissection of a cervical artery is a well-known cause of stroke, especially in younger patients. We describe the case of a 39-year-old male, who presented to our emergency department after a one-day history of headache and vomiting, with associated sudden onset posterior neck pain and cerebellar signs following a massage. Computed tomography angiogram and brain demonstrated bilateral vertebral artery dissection and cerebellar stroke. Read More

N Z Med J 2020 04 3;133(1512):15-21. Epub 2020 Apr 3.

General Medicine and Stroke Physician, Department of General Medicine, Waitemata District Health Board, Auckland.

Background: This is a baseline clinical audit looking at indwelling urinary catheter (IDC) use and trial removal of catheter (TROC) in stroke patients. We collected data on stroke patients admitted to North Shore Hospital between 26 November 2018-24 May 2019, who underwent insertion of an IDC as an inpatient. A minority of patients had TROC within the recommended guideline period. Read More

J Am Coll Cardiol 2020 Apr;75(13):1562-1564

Section of Cardiology, Baylor College of Medicine and Michael E. DeBakey VA Medical Center, Houston, Texas.

Circ J 2020 Apr 2;84(5):742-753. Epub 2020 Apr 2.

Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University.

Background: An inverse relationship exists between hospital case volume and mortality in patients with heart failure (HF). However, hospital performance factors associated with mortality in HF patients have not been examined. We aimed to identify these using exploratory factor analysis and assess the relationship between these factors and 7-day, 30-day, and in-hospital mortality among HF patients in Japan. Read More

J Immunol 2020 May 30;204(10):2722-2733. Epub 2020 Mar 30.

Center for AIDS Research, Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland, OH 44106;

Cytotoxic CD4 T cells are linked to cardiovascular morbidities and accumulate in both HIV and CMV infections, both of which are associated with increased risk of cardiovascular disease (CVD). In this study, we identify CMV coinfection as a major driver of the cytotoxic phenotype, characterized by elevated CD57 expression and reduced CD28 expression, in circulating CD4 T cells from people living with HIV infection, and investigate potential mechanisms linking this cell population to CVD. We find that human CD57 CD4 T cells express high levels of the costimulatory receptor CD2 and that CD2/LFA-3 costimulation results in a more robust and polyfunctional effector response to TCR signals, compared with CD28-mediated costimulation. Read More

Circulation 2020 Mar 29. Epub 2020 Mar 29.

Institute for Health Metrics and Evaluation & Department of Health Metrics Sciences, School of Medicine & Division of Cardiology, University of Washington, Seattle, WA.

Non-rheumatic valvular heart diseases (NRVDs) are common; however, no studies have estimated their global or national burden. As part of the Global Burden of Disease (GBD) 2017 study, mortality, prevalence, and disability-adjusted life years (DALYs) for calcific aortic valve disease (CAVD), degenerative mitral valve disease (DMVD), and other NRVD were estimated for 195 countries and territories from 1990 to 2017. Vital registration data, epidemiological survey data, and administrative hospital data were used to estimate disease burden using the GBD modeling framework, which ensures comparability across locations. Read More

BMJ 2020 03 25;368:m520. Epub 2020 Mar 25.

Bazian, Economist Intelligence Unit healthcare, London, UK.

The studyPalmer R, Dimairo M, Cooper C, et al. Self-managed, computerised speech and language therapy for patients with chronic aphasia post-stroke compared with usual care or attention control (Big CACTUS): a multicentre, single-blinded, randomised controlled trial. 2019;18:821-33. Read More

Zhen Ci Yan Jiu 2020 Mar;45(3):202-8

Department of Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300112, China.

Objective: To explore the mechanism of electroacupuncture (EA) underlying improvement of cerebral infarction (CI) by investigating its influence on expression of cerebral Wnt7a, lymphoid enhancer factor-1 (LEF1), glycogen synthase kinase 3β(GSK-3β) and Dickkopf-1(DKK1) mRNA and proteins in CI rats.

Methods: A total of 280 male Wistar rats were randomly divided into blank control (＝10), sham-operation, model and EA groups，and 90 rats of the last 3 groups were further divided into 1, 3, 6, 9, 12 and 24 h, and 3, 7 and 12 d subgroups with 10 rats in each subgroup. The CI model was established by occlusion of the middle cerebral artery (MCAO). Read More

Stroke 2020 May 23;51(5):1563-1569. Epub 2020 Mar 23.

Icahn School of Medicine at Mount Sinai, New York, NY (B.G.V.).

Background and Purpose- Lowering blood pressure and cholesterol, antiplatelet/antithrombotic use, and smoking cessation reduce risk of recurrent stroke. However, gaps in risk factor control among stroke survivors warrant development and evaluation of alternative care delivery models that aim to simultaneously improve multiple risk factors. Randomized trials of care delivery models are rarely of sufficient duration or size to be powered for low-frequency outcomes such as observed recurrent stroke. Read More

J Prosthodont Res 2020 Jul 19;64(3):346-353. Epub 2020 Mar 19.

Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, 6-1 Kishibe-Shimmachi, Suita, Osaka, 564-8565, Japan.

Purpose: The association between periodontal disease and carotid atherosclerosis has been widely discussed, but to our knowledge, no population-based studies have been conducted on the association between masticatory ability and carotid atherosclerosis. We aimed to clarify the hypothesis that objectively accessed masticatory performance is related to increased intima-media thickness (IMT) in a general urban population.

Methods: We studied 1,484 Japanese (mean age: 66. Read More

Redox Biol 2020 Mar 13:101503. Epub 2020 Mar 13.

Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, 350001, China; Department of Rehabilitation, Fujian Medical University Union Hospital, Fuzhou, 350001, China; Institute of Cerebral Vascular Disease of Fujian Province, Fuzhou, 350001, China; Key Laboratory of Brain Aging and Neurodegenerative Diseases, Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, 350001, China. Electronic address:

Background: Ischemic stroke can induce changes in mitochondrial morphology and function. As a regulatory gene in mitochondria, optic atrophy 1 (OPA1) plays a pivotal role in the regulation of mitochondrial dynamics and other related functions. However, its roles in cerebral ischemia-related conditions are barely understood. Read More

Medicine (Baltimore) 2020 Mar;99(12):e19427

Obstetrics and Gynecology Unit, Torrecárdenas University Hospital, Almería.

Background: Severe and morbid obesity are increasing globally, particularly in women. As BMI increases, the likelihood of anovulation is higher. The primary aim of the EMOVAR clinical trial is to examine, over the short (16 weeks) and medium (12 months) term, the effects of a supervised physical exercise program (focused primarily on aerobic and resistance training) on ovarian function in women with severe/morbid obesity who have undergone bariatric surgery. Read More

Medicine (Baltimore) 2020 Mar;99(12):e18969

Guangzhou University of Chinese Medicine.

Background: Post-stroke depression (PSD) is the most common emotional problem after stroke. It can lower the quality of life and increase the recurrence and mortality. Pharmacological agents have been shown to treat PSD. Read More