1,258,443 results match your criteria Vascular Dementia


Flow-Through Flaps in the Absence of an Arterial Gap for Extremity Defect Reconstruction: Minimizing the Donor-Site Morbidity.

J Reconstr Microsurg 2018 Dec 17. Epub 2018 Dec 17.

Department of Plastic and Reconstructive Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.

Background:  The use of flow-through flaps was popularized in the early 1990s by Costa, Soutar and Lamberty in cases where an arterial gap was present or a major artery of the limb was damaged. We hypothesized that flow-through flaps can be used in all extremity reconstruction cases, where there is an indication for a free-flap, irrespective of the existence of arterial defect due to its many advantages while not increasing the flap loss significantly.

Methods:  A retrospective study was performed by examining patient status and surgery reports of all patients who underwent extremity reconstruction with a flow-through flap from January 2011 to January 2016. Read More

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December 2018

Platelet-Dense Granules Worsen Pre-Infection Thrombocytopenia during Gram-Negative Pneumonia-Derived Sepsis.

J Innate Immun 2018 Dec 17:1-13. Epub 2018 Dec 17.

Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Platelet-dense (δ) granules are important for platelet function. Platelets contribute to host defense and vascular integrity during pneumonia and sepsis, and δ granule products, including adenosine diphosphate (ADP), can influence inflammatory responses. We therefore aimed to study the role of platelet δ granules in the host response during sepsis. Read More

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December 2018

Impairment in complex activities of daily living is related to neurodegeneration in Alzheimer's disease-specific regions.

Neurobiol Aging 2018 Nov 26;75:109-116. Epub 2018 Nov 26.

Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Department of Epidemiology & Biostatistics, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Impairment in instrumental activities of daily living (IADL) is an early clinical feature of Alzheimer's disease (AD). The neurobiology underlying IADL disruptions is still unclear. We aimed to investigate the relationship between IADL functioning and cortical atrophy across the AD spectrum. Read More

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November 2018

Resting state functional connectivity and neural correlates of face-name encoding in patients with ischemic vascular lesions with and without the involvement of the left inferior frontal gyrus.

Cortex 2018 Nov 26;113:15-28. Epub 2018 Nov 26.

Department of Neurology, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, SP, Brazil. Electronic address:

Face-name association is a relevant ability for social interactions and involves the ventral and dorsolateral prefrontal cortices, particularly in the left hemisphere, bilateral hippocampal, fusiform gyrus and occipital regions. Previous studies demonstrated the primary role of the hippocampus for this ability in healthy subjects. However, no study has examined the participation of the left inferior frontal area, specially the left inferior frontal gyrus (LIFG) in patients with ischemic vascular lesions. Read More

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November 2018

The Intestinal Lymphatic System: Functions and Metabolic Implications.

Cell Mol Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.

Cardiovascular Research Center and Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT 06510-3221, USA; INSERM U970, Paris Cardiovascular Research Center, 75015 Paris, France.

The lymphatic system of the gut plays important roles in the transport of dietary lipids, as well as in immunosurveillance and removal of interstitial fluid. Historically, despite its crucial functions in intestinal homeostasis, the lymphatic system has been poorly studied. In the last two decades, identification of specific molecular mediators of lymphatic endothelial cells (LECs) growth together with novel genetic approaches and intravital imaging techniques, have advanced our understanding of the mechanisms regulating intestinal lymphatic physiology in health and disease. Read More

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December 2018

Cellular responses to thermoresponsive stiffness memory elastomer nanohybrid scaffolds by 3D-TIPS.

Acta Biomater 2018 Dec 14. Epub 2018 Dec 14.

Centre for Biomaterials in Surgical Reconstruction and Regeneration, Division of Surgery & Interventional Science, University College London, London, NW3 2PF, United Kingdom. Electronic address:

Increasing evidence suggests the contribution of the dynamic mechanical properties of the extracellular matrix (ECM) to regulate tissue remodeling and regeneration. Following our recent study on a family of thermoresponsive 'stiffness memory' elastomeric nanohybrid scaffolds manufactured via an indirect 3D printing guided thermo-induced phase separation process (3D-TIPS), this work reports in vitro and in vivo cellular responses towards these scaffolds with different initial stiffness and hierarchical interconnected porous structure. The viability of mouse embryonic dermal fibroblasts in vitro and the tissue responses during the stiffness softening of the scaffolds subcutaneously implanted in rats for three months were evaluated by immunohistochemistry and histology. Read More

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December 2018

Vascular burden and APOE ε4 are associated with white matter microstructural decline in cognitively normal older adults.

Neuroimage 2018 Dec 14. Epub 2018 Dec 14.

Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD 21224, USA.

White matter microstructure can be measured with diffusion tensor imaging (DTI). While increasing age is a predictor of white matter (WM) microstructure changes, roles of other possible modifiers, such as cardiovascular risk factors, APOE ε4 allele status and biological sex have not been clarified. We investigated 665 cognitively normal participants from the Baltimore Longitudinal Study of Aging (age 50-95, 56. Read More

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December 2018

Diurnal Regulation of Sphingolipids in Blood.

Biochim Biophys Acta Mol Cell Biol Lipids 2018 Dec 14. Epub 2018 Dec 14.

Department of General Pharmacology and Toxicology, Goethe University Hospital, Frankfurt am Main, Germany.

Key homeostatic functions are regulated in a diurnal manner and a miss-alignment of such rhythms is believed to contribute to the pathophysiology of several diseases. Signaling sphingolipids (SLs) in plasma such as sphingosine 1-phosphate control lymphocytic trafficking, vascular reactivity and platelet activity, physiological functions all of which display a diurnal rhythm themselves. However, the rhythmicity of SL metabolism in plasma and its potential causes have not been sufficiently investigated so far. Read More

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December 2018

Inositol hexakisphosphate increases the size of platelet aggregates.

Biochem Pharmacol 2018 Dec 14. Epub 2018 Dec 14.

Department of Biochemistry and Signal Transduction, University Medical Center Hamburg-Eppendorf, Martinistrasse 52 D-20246 Hamburg, Germany. Electronic address:

The inositol phosphates, InsP and InsP, have recently been identified as binding partners of fibrinogen, which is critically involved in hemostasis by crosslinking activated platelets at sites of vascular injury. Here, we investigated the putative physiological role of this interaction and found that platelets increase their InsP concentration upon stimulation with the PLC-activating agonists thrombin, collagen I and ADP and present a fraction of it at the outer plasma membrane. Cone and plate analysis in whole blood revealed that InsP specifically increases platelet aggregate size. Read More

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December 2018

Evidence for Fucoidan-P-selectin Axis as a Therapeutic Target on Hypoxia-induced Pulmonary Hypertension.

Am J Respir Crit Care Med 2018 Dec 17. Epub 2018 Dec 17.

Justus-Leibig-University, Internal Medicine, Giessen, Germany ;

Rationale: Pulmonary arterial hypertension (PAH) is characterized by vascular remodeling and excessive proliferation of pulmonary artery smooth muscle cells (PASMCs). Fucoidan, polysacharidic ligand of an adhesion molecule P-selectin exhibits anti-proliferative properties. The effects of Fucoidan/P-selectin axis on vascular remodeling and pulmonary hypertension (PH) following hypoxia remain unexplored. Read More

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December 2018

Disconnect between Fibrotic Response and Right Ventricular Dysfunction.

Am J Respir Crit Care Med 2018 Dec 17. Epub 2018 Dec 17.

Ludwig Boltzmann Institute for Lung Vascular Research, Graz, Austria ;

Rationale: Remodeling and fibrosis of the right ventricle (RV) may cause RV dysfunction and poor survival in patients with pulmonary hypertension (PH).

Objectives: To investigate the consequences of RV fibrosis modulation and the accompanying cellular changes on RV function.

Methods: Expression of fibrotic markers was assessed in the RV of PH patients, the murine pulmonary artery banding (PAB)-, and rat monocrotaline-, and Sugen5416/hypoxia models. Read More

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December 2018

Fabrication of scaffold-free tubular cardiac constructs using a Bio-3D printer.

PLoS One 2018 17;13(12):e0209162. Epub 2018 Dec 17.

Department of Regenerative Medicine and Biomedical Engineering, Faculty of Medicine, Saga University, Saga, Japan.

A major challenge in cardiac tissue engineering is the host's immune response to artificial materials. To overcome this problem, we established a scaffold-free system for assembling cell constructs using an automated Bio-3D printer. This printer has previously been used to fabricate other three-dimensional (3D) constructs, including liver, blood vessels, and cartilage. Read More

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December 2018

Systematic in vitro comparison of decellularization protocols for blood vessels.

PLoS One 2018 17;13(12):e0209269. Epub 2018 Dec 17.

Department of Molecular and Clinical Medicine/Wallenberg Laboratory, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg, Sweden.

Decellularization of native blood vessels is a promising technology to generate 3D biological scaffolds for vascular grafting. Blood vessel decellularization has been performed in previous studies under various experimental conditions, that complicates comparison and optimization of suitable protocols. The goal of this work was to systematically compare the decellularization and recellularization efficacy of 5 different protocols utilizing the detergents sodium dodecyl sulfate (SDS), sodium deoxycholate (SDC), CHAPS and TritonX-100 together with DNA-removing enzymes on porcine vena cava in a perfusion bioreactor setup. Read More

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December 2018

Multimorbidity patterns in high-need, high-cost elderly patients.

PLoS One 2018 17;13(12):e0208875. Epub 2018 Dec 17.

Department of Statistical Sciences, University of Padova, Padova, Italy.

Introduction: Patients with complex health care needs (PCHCN) are individuals who require numerous, costly care services and have been shown to place a heavy burden on health care resources. It has been argued that an important issue in providing value-based primary care concerns how to identify groups of patients with similar needs (who pose similar challenges) so that care teams and care delivery processes can be tailored to each patient subgroup. Our study aims to describe the most common chronic conditions and their combinations in a cohort of elderly PCHCN. Read More

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December 2018

Role of CTRP3, CTRP9 and MCP-1 for the evaluation of T2DM associated coronary artery disease in Egyptian postmenopausal females.

PLoS One 2018 17;13(12):e0208038. Epub 2018 Dec 17.

Biochemistry Department, Faculty of Pharmacy, Ain Shams University, African Union Authority St. Abassia, Cairo, Egypt.

C1q complement/tumor necrosis factor (TNF)-related protein (CTRP) family comprises of 15 proteins that posses important implications in energy homeostasis, infection and inflammation. However, their roles in diabetes mellitus (DM) and its vascular complications have not been completely assessed. This works aims to study the association of two CTRPs; 3 and 9, with pro-inflammatory cytokine monocyte chemoattractant protein-1 (MCP-1), and biochemical parameters of type 2 diabetes (T2D), dyslipidemia and coronary artery disease (CAD). Read More

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December 2018

The sickle cell trait and end stage renal disease in Salvador, Brazil.

PLoS One 2018 17;13(12):e0209036. Epub 2018 Dec 17.

Instituto Gonçalo Moniz-FIOCRUZ-Bahia, Salvador, Brazil.

Background: Carriers of the sickle cell trait (HbAS) usually remain asymptomatic. However, under conditions of low tissue oxygenation, red blood cell sickling and vascular obstruction may develop. Chronic kidney disease (CKD) can arise from conditions promoting low-oxygen in kidney tissue, which may be aggravated by the presence of the sickle cell trait. Read More

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December 2018

L1 Cell Adhesion Molecule (L1CAM) expression in endometrioid endometrial carcinomas: A possible pre-operative surrogate of lymph vascular space invasion.

PLoS One 2018 17;13(12):e0209294. Epub 2018 Dec 17.

Department of Pathology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.

Background: Risk stratification of endometrial carcinomas is primarily based on surgical staging that requires extensive retroperitoneal lymph node dissection. One of the most powerful predictor of lymph node involvement is the lymph vascular space invasion (LVSI). The objective of this study was to determine the potential of L1 Cell Adhesion Molecule (L1CAM) to predict LVSI and its association with other risk factors in endometrioid endometrial carcinomas. Read More

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December 2018

Antegrade Transpulmonary Blood Flow: Essential for Surviving Veno-Arterial Extracorporeal Membrane Oxygenation.

Crit Care Med 2019 Jan;47(1):e70-e71

Cardiac Arrest Center, Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany Cardiovascular Research Foundation, New York, NY Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, Heinrich-Heine-University, Düsseldorf, Germany.

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January 2019

Impact of preclinical carotid atherosclerosis on global cardiovascular risk stratification and events in a 10-year follow-up: comparison between the algorithms of the Framingham Heart Study, the European SCORE and the Italian 'Progetto Cuore'.

J Cardiovasc Med (Hagerstown) 2018 Dec 14. Epub 2018 Dec 14.

Chair and Division of Cardiology, University Hospital Policlinico 'Paolo Giaccone', Palermo, Italy.

Background: The aim of the study was to compare three widely used algorithms for stratification of the global cardiovascular risk (GCVR): the Framingham Heart Study (FHS) score, the European systemic coronary risk estimation (SCORE) and the Italian 'Progetto Cuore' (heart project) score. It was also investigated how preclinical carotid atherosclerosis (pre-ATS) might influence the incidence and improve the risk prediction of cerebrovascular and cardiovascular events.

Methods: Subjects (n = 358) without previous history of cardiovascular disease (CVD) were recruited and the GCVR was calculated for each patient. Read More

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December 2018

The Medial Pillar Island Flap for Oncoplastic Breast Reconstruction of Upper Pole Defects.

Ann Plast Surg 2018 Dec 13. Epub 2018 Dec 13.

Surgical Oncology, Department of Surgery, University of Massachusetts Medical School, Worcester, MA.

Background: Breast deformity is common following lumpectomy. Use of ptotic lower pole tissue for restoration of volume in the upper pole is quite appealing since it allows for a concomitant lift. This study presents the medial pillar island flap technique of oncoplastic breast reconstruction of upper pole defects. Read More

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December 2018

Photodynamic therapy in infected venous and mixed leg ulcers: a pilot experience.

J Wound Care 2018 Dec;27(12):816-821

Consultant, Angiology Department, MD Barbantini Clinic, Lucca, Italy.

Objective:: To assess the tolerability and efficacy of photodynamic therapy (PDT) with RLP068, a novel phthalocyanine-derived photosensitiser, in controlling the bacterial load in different leg ulcers, due to vascular pathophysiology.

Method:: An observational study of patients with infected leg ulcers of different pathophysiology, admitted to the hospital for a skin grafting procedure, were included. All patients underwent two sessions of PDT at time zero and after 72 hours. Read More

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December 2018
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Investigation of galectin-3 levels in diabetic foot ulcers.

J Wound Care 2018 Dec;27(12):843-848

Professor, Harran University, School of Medicine, Department of Endocrinology, Sanliurfa, Turkey.

Objective:: It has been shown that galectin-3 (Gal-3) promotes angiogenesis and new vessel formation. Serum Gal-3 is a risk factor for vascular complications in type 2 diabetes. The aim of this study is to compare Gal-3 levels with a range of biochemical parameters. Read More

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December 2018

Behcet's Disease in Iran; Analysis of 7641 Cases.

Mod Rheumatol 2018 Dec 17:1-21. Epub 2018 Dec 17.

a Behcet's Disease Unit, Rheumatology Research Center , Shariati Hospital, Tehran University of Medical Sciences , Tehran , Iran.

Objective: To analyze Behcet's Disease (BD) in Iran, from 1975 to 2018, and compare to 35 large/small reports from other countries.

Methods: Patients from all over Iran, when suspected, were sent to the BD Unit. The diagnosis was done by expert opinion. Read More

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December 2018
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Evidence-Based Performance Measures and Outcomes in Patients With Acute Ischemic Stroke.

Circ Cardiovasc Qual Outcomes 2018 Dec;11(12):e001968

TianTan Clinical Trial and Research Center for Stroke, Department of Neurology, Beijing TianTan Hospital, Capital Medical University, China (Yilong Wang, Chunjuan Wang, H.L., Yongjun Wang).

Background: Stroke is the leading cause of death in China. Despite the wide dissemination of evidence-based guidelines, data about adherence to these in routine clinical practice are scarce. We conducted a study using a nationwide registry to evaluate the implementation of evidence-based stroke performance indicators and associated guidelines, for patients with an ischemic stroke in China. Read More

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December 2018

Rapid endothelialization and controlled smooth muscle regeneration by electrospun heparin-loaded polycaprolactone/gelatin hybrid vascular grafts.

J Biomed Mater Res B Appl Biomater 2018 Dec 17. Epub 2018 Dec 17.

Key Laboratory of Bioactive Materials for Ministry of Education, College of Life Sciences, Nankai University, Tianjin, 300071, China.

The bioinert characteristic of polycaprolactone (PCL) remains a major defect when using PCL-based materials as small-diameter vascular grafts for implantation in vivo. To improve the hydrophilicity, cytocompatibility, and biodegradation of PCL vascular grafts, we constructed hybrid vascular grafts from electrospun PCL/gelatin. The PCL/gelatin hybrid vascular graft was further functionalized with the addition of heparin, to improve hemocompatibility. Read More

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December 2018

Long-term health-related quality of life in children with lymphatic malformations treated with sclerotherapy generally matched age-appropriate standardised population norms.

Acta Paediatr 2018 Dec 17. Epub 2018 Dec 17.

Department of Women's and Children's Health, Clinical Psychology Unit, Uppsala University, Uppsala, Sweden.

Aim: We assessed the long-term health-related quality of life (HRQoL) of children who received sclerotherapy for lymphatic malformations. This involved injecting drugs into the blood vessels to make them shrink.

Methods: Our cross-sectional study retrospectively reviewed patients who received OK-432 sclerotherapy injections at Karolinska University Hospital, Stockholm, Sweden, from 1998-2013. Read More

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December 2018

Fabrication of plumbagin on silver nanoframework for tunable redox modulation: Implications for therapeutic angiogenesis.

J Cell Physiol 2018 Dec 17. Epub 2018 Dec 17.

Biological Materials Laboratory, CSIR-Central Leather Research Institute, Chennai, India.

The redox state of the endothelial cells plays a key role in the regulation of the angiogenic process. The modulation of the redox state of endothelial cells (ECs) could be a viable target to alter angiogenic response. In the present work, we synthesized a redox modulator by caging 5-hydroxy 2-methyl 1, 4-napthoquinone (Plumbagin) on silver nano framework (PCSN) for tunable reactive oxygen species (ROS) inductive property and tested its role in ECs during angiogenic response in physiological and stimulated conditions. Read More

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December 2018

Lycophyte plastid genomics: extreme variation in GC, gene and intron content and multiple inversions between a direct and inverted orientation of the rRNA repeat.

New Phytol 2018 Dec 17. Epub 2018 Dec 17.

Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI, 48109, USA.

Lycophytes are a key group for understanding vascular plant evolution. Lycophyte plastomes are highly distinct, indicating a dynamic evolutionary history, but detailed evaluation is hindered by the limited availability of sequences. Eight diverse plastomes were sequenced to assess variation in structure and functional content across lycophytes. Read More

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December 2018

Retigabine protects the blood-brain barrier by regulating tight junctions between cerebral vascular endothelial cells in cerebral ischemia-reperfusion rats.

Eur Rev Med Pharmacol Sci 2018 Dec;22(23):8509-8518

Department of Neurology, the Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.

Objective: To investigate the effect of retigabine on the blood-brain barrier permeability in rats with cerebral ischemia-reperfusion and its mechanism.

Materials And Methods: A total of 90 Sprague-Dawley (SD) rats were selected to prepare a rat model of focal cerebral ischemia-reperfusion. The blood flow changes were detected using a laser Doppler flow meter, the percentage of the cerebral infarction volume was measured by means of the triphenyl tetrazolium chloride (TTC) staining, the effect of retigabine on the permeability of the blood-brain barrier after cerebral ischemia-reperfusion was examined via Evans blue (EB) staining, and the state of tight junctions between endothelial cells was determined via the transmission electron microscopy (TEM) technique. Read More

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December 2018

Temporal Trends in Unstable Angina Diagnosis Codes for Outpatient Percutaneous Coronary Interventions.

JAMA Intern Med 2018 Dec 17. Epub 2018 Dec 17.

Richard and Susan Smith Center for Outcomes Research in Cardiology, Division of Cardiology, Beth Israel Deaconess Medical and Harvard Medical School, Boston, Massachusetts.

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December 2018

Ocular Posterior Segment Involvement in Patients with Antiphospholipid Syndrome and Systemic Lupus Erythematosus.

Ocul Immunol Inflamm 2018 Dec 17:1-6. Epub 2018 Dec 17.

d Department of Ophthalmology , Marmara University School of Medicine , Istanbul , Turkey.

Purpose: To describe posterior segment findings of antiphospholipid syndrome (APS) and compare them with systemic lupus erythematosus (SLE).

Methods: A total of 11 patients with primary APS, 29 secondary APS patients, and 29 SLE patients without APS were included. All patients were referred from rheumatology clinic for detailed ophthalmologic examination. Read More

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December 2018

Elevated arterial shear rate increases indexes of endothelial cell autophagy and nitric oxide synthase activation in humans.

Am J Physiol Heart Circ Physiol 2019 Jan 9;316(1):H106-H112. Epub 2018 Nov 9.

Department of Nutrition and Integrative Physiology, University of Utah , Salt Lake City, Utah.

Continuous laminar shear stress increases the process of autophagy, activates endothelial nitric oxide (NO) synthase phosphorylation at serine 1177 (p-eNOS), and generates NO in bovine and human arterial endothelial cells (ECs) compared with static controls. However, the translational relevance of these findings has not been explored. In the current study, primary ECs were collected from the radial artery of 7 men using sterile J-wires before (Pre) and after (Post) 60 min of rhythmic handgrip exercise (HG) performed with the same arm. Read More

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January 2019

Bevacizumab in refractory higher-grade and atypical meningioma: the current state of affairs.

Expert Opin Biol Ther 2018 Dec 17:1-6. Epub 2018 Dec 17.

e Department of Radiology and Imaging , State University of Medicine and Pharmacy "Nicolae Testemitanu" , Chisinau , Moldova.

Introduction: Historically, systemic agents had shown limited efficacy in meningioma, at the expense of significant pharmacologic and/or financial toxicity. As meningiomas are highly vascularized, they might derive benefit from antiangiogenic therapy. Areas covered: This review summarizes the literature regarding bevacizumab pharmacology, safety and efficacy in patients with refractory meningioma. Read More

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December 2018

ADAM9 contributes to vascular invasion in pancreatic ductal adenocarcinoma.

Mol Oncol 2018 Dec 17. Epub 2018 Dec 17.

Faculty of Medicine, University of Freiburg, Germany.

A disintegrin and a metalloprotease (ADAM) 9 is a metzincin cell-surface protease with strongly elevated expression in solid tumors, including pancreatic ductal adenocarcinoma (PDAC). In this study, we performed immunohistochemistry (IHC) of a tissue microarray (TMA) to examine the expression of ADAM9 in a cohort of > 100 clinically-annotated PDAC cases. We report that ADAM9 is prominently expressed by PDAC tumor cells, and increased ADAM9 expression levels correlate with poor tumor grading (p = 0. Read More

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December 2018

Quantitative susceptibility mapping detects neovascularization of the epiphyseal cartilage after ischemic injury in a piglet model of legg-calvé-perthes disease.

J Magn Reson Imaging 2018 Dec 17. Epub 2018 Dec 17.

Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minnesota, USA.

Background: Legg-Calvé-Perthes disease (LCPD) is a childhood hip disorder thought to be caused by disruption of blood supply to the developing femoral head. There is potential for imaging to help assess revascularization of the femoral head.

Purpose: To investigate whether quantitative susceptibility mapping (QSM) can detect neovascularization in the epiphyseal cartilage following ischemic injury to the developing femoral head. Read More

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December 2018
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Visceral Obesity Relates to Deep White Matter Hyperintensities via Inflammation.

Ann Neurol 2018 Dec 17. Epub 2018 Dec 17.

Department of Neurology, Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

Objective: White matter hyperintensities (WMH) are linked to vascular risk factors and increase the risk of cognitive decline, dementia and stroke. We here aimed to determine if obesity contributes to regional WMH using a whole-brain approach in a well-characterized population-based cohort.

Methods: Waist-to-hip ratio (WHR), body mass index (BMI), systolic/diastolic blood pressure, hypertension, diabetes and smoking status, blood glucose and inflammatory markers as well as distribution of WMH were assessed in 1825 participants of the LIFE-adult study (age 20-82 years; BMI 18. Read More

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December 2018

microRNA-338-3p promotes ox-LDL-induced endothelial cell injury through targeting BAMBI and activating TGF-β/Smad pathway.

J Cell Physiol 2018 Dec 17. Epub 2018 Dec 17.

Department of Vascular Surgery, China-Japan Union Hospital, Jilin University, Changchun, Jilin, China.

microRNAs (miRNAs) have been revealed to participate in the pathological process of atherosclerosis (AS). However, the exact role of miR-338-3p, a target miRNA of BMP and activin membrane-bound inhibitor (BAMBI), and its possible molecular mechanism in AS remain unidentified. In this study, we found that BAMBI was significantly decreased, whereas miR-338-3p increased in patients with AS and oxidized low-density lipoprotein (ox-LDL)-induced HUVEC cells. Read More

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December 2018

Lead Intoxication in Free-Ranging Bald Eagles ( Haliaeetus leucocephalus).

Vet Pathol 2018 Dec 16:300985818813099. Epub 2018 Dec 16.

2 The Raptor Center, University of Minnesota, St. Paul, MN, USA.

Lead toxicity due to ingestion of spent ammunition is an ongoing cause of mortality in bald eagles. While gross and histologic lesions of lead intoxication have been described in a few individuals of this species, the prevalence of lesions is underreported. A retrospective study of 93 bald eagles with severe lead intoxication was performed to describe the associated lesions and their prevalence and to compare the lesions with blood, liver, kidney, and/or bone lead concentrations. Read More

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December 2018

Detecting the Media-adventitia Border in Intravascular Ultrasound Images through a Classification-based Approach.

Ultrason Imaging 2018 Dec 16:161734618820112. Epub 2018 Dec 16.

1 School of Information & Electrical Engineering, Zhejiang University City College, Hangzhou, China.

The detection of the media-adventitia (MA) border in intravascular ultrasound (IVUS) images is essential for vessel assessment and disease diagnosis. However, it remains a challenging task, considering the existence of plaque, calcification, and various artifacts. In this article, an effective method based on classification is proposed to extract the MA border in IVUS images. Read More

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December 2018

Intravitreal fluocinolone acetonide implant (ILUVIEN®) for diabetic macular oedema: a literature review.

J Int Med Res 2018 Dec 16:300060518816884. Epub 2018 Dec 16.

2 Eye Treatment Centre, Whipps Cross University Hospital, Barts Health NHS Trust, London, UK.

Diabetic macular oedema (DMO) is a common complication of diabetic retinopathy and may lead to severe visual loss. In this review, we describe the pathophysiology of DMO and review current therapeutic options such as macular laser photocoagulation, anti-vascular endothelial growth factor agents, and steroid implants with a focus on the new fluocinolone acetonide implant, ILUVIEN®. The results of the Fluocinolone Acetonide in Diabetic Macular Edema (FAME) studies are also presented together with the results of real-world studies to support the clinical use of ILUVIEN® in achieving efficient resolution of DMO and improving vision and macular anatomy in this challenging group of patients. Read More

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December 2018

Transient power elevation during iron dextran infusion in a patient with a continuous-flow left ventricular assist device.

Int J Artif Organs 2018 Dec 16:391398818818565. Epub 2018 Dec 16.

6 Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, OH, USA.

Anemia is common in patients with mechanical circulatory support and is associated with increased morbidity. Repletion using parenteral iron infusions has been proven to be beneficial in patients with heart failure. In this report, we describe a case of increased power and flows of continuous-flow left ventricular assist device (LVAD) during an iron dextran infusion. Read More

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December 2018

Chicken endothelial cells are highly responsive to viral innate immune stimuli and are susceptible to infections with various avian pathogens.

Avian Pathol 2018 Dec 17:1-41. Epub 2018 Dec 17.

a INRA, Université François Rabelais , UMR1282 Infectiologie et Santé Publique , 37380 Nouzilly , France.

It is well established that the endothelium plays a prominent role in the pathogenesis of various infectious diseases in mammals. However, little is known about the role of endothelial cells (EC) as targets for avian pathogens and their contribution to the pathogenesis of infectious diseases in galliform birds. First, we explored the innate immune response of primary chicken aortic endothelial cells (pchAEC) obtained from 18 day-old embryos to stimulation with pathogen-associated molecular patterns (PAMPs) or recombinant chicken interferons (type I, II and III IFNs). Read More

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December 2018

Transilluminated Powered Phlebectomy in the Treatment of Large Area Venous Leg Ulcers: a case-control study with 3 years follow-up.

Microcirculation 2018 Dec 16:e12523. Epub 2018 Dec 16.

Department of Vascular Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.

Objective: To evaluate the efficacy, safety and long-term outcome of transilluminated powered phlebectomy (TIPP) for the adjunct therapy of superficial venous reflux -related venous leg ulcers (VLUs).

Methods: A total of 93 consecutive patients (104 legs) with superficial venous insufficiency-related VLUs who underwent TIPP (53 legs) or conventional phlebectomy (51 legs) between January 2010 and December 2013 were retrospectively studied.

Results: Compared to patients in the conventional phlebectomy group, TIPP patients had larger ulcer areas before surgery (p <. Read More

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December 2018

The pulsatile component of left atrial pressure has little effect on pulmonary artery impedance estimation in normal rats.

Physiol Rep 2018 Dec;6(24):e13946

Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka, Japan.

Pulmonary artery impedance (PAZ) that measures the pulsatile properties of the vasculature provides diagnostic and prognostic information in patients with pulmonary vascular diseases. While downstream pressure [i.e. Read More

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December 2018

Monitoring circulating tumor cells in vivo by a confocal microscopy system.

Cytometry A 2018 Dec 17. Epub 2018 Dec 17.

School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China.

Circulating tumor cells (CTCs) play a key role in cancer metastasis but are very difficult to detect. in vivo monitoring CTCs has been recognized as an important technique for cancer research and clinical diagnosis. Recently, a noninvasive method, in vivo flow cytometry (IVFC) has been developed to enable continuous, real-time, and long-duration detection of CTCs in animal models by detecting CTC fluorescence in blood vessels excited by lasers. Read More

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December 2018

Identification of pathogenic YY1AP1 splice variants in siblings with Grange syndrome by whole exome sequencing.

Am J Med Genet A 2018 Dec 17. Epub 2018 Dec 17.

Department of Human Genetics, University Medicine Greifswald, and Interfaculty Institute of Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany.

Grange syndrome is an autosomal recessive condition characterized by arterial occlusions and hypertension. Syndactyly, brachydactyly, bone fragility, heart defects, and learning disabilities have also been reported. Loss-of-function variants in YY1AP1 have only recently been associated with Grange syndrome. Read More

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December 2018

Prenatal hypoxia plus postnatal high-fat diet exacerbated vascular dysfunction via up-regulated vascular Cav1.2 channels in offspring rats.

J Cell Mol Med 2018 Dec 16. Epub 2018 Dec 16.

Institute for Fetology, First Hospital of Soochow University, Suzhou, China.

Background: This study aimed to examine whether and how postnatal high-fat diet had additional impact on promoting vascular dysfunction in the offspring exposed to prenatal hypoxia.

Methods And Results: Pregnant Sprague-Dawley rats were randomly assigned to hypoxia (10.5% oxygen) or normoxia (21% O ) groups from gestation days 5-21. Read More

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December 2018

FAM134B induces tumorigenesis and epithelial-to-mesenchymal transition via Akt signaling in hepatocellular carcinoma.

Mol Oncol 2018 Dec 16. Epub 2018 Dec 16.

Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Key Laboratory of Organ Transplantation, Ministry of Education and Ministry of Public Health; Clinical Medicine Research Center of Hepatic Surgery in Hubei Province, Wuhan, 430030, P.R.China.

Fam134b (JK-1, RETREG1) was first identified as an oncogene in esophageal squamous cell carcinoma. However, the roles of FAM134B during tumorigenesis of hepatocellular carcinoma (HCC) and in epithelial-to-mesenchymal transition (EMT) were previously unclear. In this study, we investigated the function of FAM134B in HCC and the related tumorigenesis mechanisms, as well as how FAM134B induces EMT. Read More

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December 2018

Targeting the vascular dysfunction: potential treatments for preeclampsia.

Microcirculation 2018 Dec 16:e12522. Epub 2018 Dec 16.

Departments of Obstetrics and Gynaecology and Medicine, School of Clinical Sciences, The Ritchie Centre, Monash University, Clayton, Victoria, Australia.

Preeclampsia is a pregnancy specific disorder, primarily characterized by new-onset hypertension in combination with a variety of other maternal or fetal signs. The pathophysiological mechanisms underlying the disease are still not entirely clear. Systemic maternal vascular dysfunction underlies the clinical features of preeclampsia. Read More

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December 2018
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