A Randomized Trial of Early Endovenous Ablation in Venous Ulceration.
- Authors:
- Manjit S Gohel,
- Francine Heatley,
- Xinxue Liu,
- Andrew Bradbury,
- Richard Bulbulia,
- Nicky Cullum,
- David M Epstein,
- Isaac Nyamekye,
- Keith R Poskitt,
- Sophie Renton,
- Jane Warwick,
- Alun H Davies,
N Engl J Med 2018 05 24;378(22):2105-2114. Epub 2018 Apr 24.
From Cambridge University Hospitals NHS Foundation Trust, Cambridge (M.S.G.), the Department of Surgery and Cancer (M.S.G., F.H., A.H.D.) and Imperial Clinical Trials Unit (X.L., J.W.), Imperial College London, London, University of Birmingham, Birmingham (A.B.), Gloucestershire Hospitals NHS Foundation Trust, Gloucester (R.B., K.R.P.), the Medical Research Council Population Health Research Unit and the Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford (R.B.), University of Manchester, Manchester (N.C.), Worcestershire Acute Hospitals NHS Trust, Worcester (I.N.), North West London Hospitals NHS Trust, Harrow (S.R.), and University of Warwick, Coventry (J.W.) - all in the United Kingdom; and the University of Granada, Granada, Spain (D.M.E.).
Background: Venous disease is the most common cause of leg ulceration. Although compression therapy improves venous ulcer healing, it does not treat the underlying causes of venous hypertension. Treatment of superficial venous reflux has been shown to reduce the rate of ulcer recurrence, but the effect of early endovenous ablation of superficial venous reflux on ulcer healing remains unclear. Read More
