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Andrologia 2022 Jun 24:e14510. Epub 2022 Jun 24.

Urology Unit, Azienda Ospedaliero-Universitaria Ospedali Riuniti di Ancona, Polytechnic University of the Marche Region, Ancona, Italy.

We aimed to systematically review complications, and recurrence rate of varicocele treatment by comparing the surgical ligature versus sclero-embolization techniques in children, adolescents and adults. The secondary outcomes were the evaluation of semen parameters and spontaneous pregnancy rate in adults. The review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses framework. Read More

J Pers Med 2022 May 25;12(6). Epub 2022 May 25.

Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del S. Cuore, 00168 Rome, Italy.

Oxidative and inflammatory damage underlie several conditions related to male infertility, including varicocele. Free light chains of immunoglobulins (FLCs) are considered markers of low-grade inflammation in numerous diseases. Coenzyme Q10 (CoQ10), a lipidic antioxidant and anti-inflammatory compound, is involved in spermatozoa energy metabolism and motility. Read More

Ann Med Surg (Lond) 2022 Jun 4;78:103937. Epub 2022 Jun 4.

Urology Department, La Rabta Hospital, Tunis, Tunisia.

Introduction: Among identified causes of male infertility, varicocele holds an important place and is significantly associated with sperm quality deterioration. Surgical management of this condition leads to an improvement in the sperm count and an increase in the spontaneous pregnancy rate.

Objective: The goal of this study was to compare different surgical techniques in terms of morbidity and fertility results. Read More

Biomed Khim 2022 Jun;68(3):228-231

Academician I.P. Pavlov Ryazan State Medical University, Ryazan, Russia.

Although the relationship between the amount of vitamin B12 and the quality of sperm exists, but results are controversial and require several additional research. The objective of our study was to analyse the amount of vitamin B12 in the sperm samples from patients with chronic prostatitis and varicocele with accompanying asthenozoospermia, and to identify the relationship between the amount of vitamin B12 and asthenozoospermia. The research was carried out of men with chronic prostatitis and varicocele with accompanying asthenozoospermia and infertility at the age of 27±2 years. Read More

Ann Vasc Surg 2022 Jun 14. Epub 2022 Jun 14.

Andrology 2022 Jun 17. Epub 2022 Jun 17.

Department of Urology, the First Affiliated Hospital of Anhui Medical University, Anhui province, China.

Background: C-reactive protein (CRP), as a marker of inflammation, may be closely related to erectile dysfunction (ED), however, there is no meta-analysis exists for it.

Objectives: We aimed to verify the relationship between CRP and erectile dysfunction and to explore the changes of CRP levels in ED patients after first-line treatment.

Materials And Methods: We searched databases including the Cochrane Library, PubMed, and MEDLINE to identify studies up to January 1, 2022. Read More

Cell J 2022 Apr 27;24(4):176-181. Epub 2022 Apr 27.

Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran. Email:

Objective: Cystathionine β-synthase (CBS) and cystathionine γ-lyase (CSE) are two important enzymes involved in One-Carbon metabolism. These enzymes play important roles in modulating oxidative stress and inflammation in male factor infertility through participating in the synthesis of glutathione (GSH) antioxidants in the trans-sulfuration pathway. Besides, the direct release of hydrogen sulfide (HS) has anti-inflammatory and antioxidant effects. Read More

Asian J Androl 2022 Jun 3. Epub 2022 Jun 3.

The Andrology Department, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.

Many therapies are effective in treating varicoceles, including dilation of the pampiniform plexus in males. The most common method of treatment is varicocelectomy. We aimed to assess an alternative technique (microsurgical spermatic [distal end]-superficial or inferior epigastric vein anastomosis) that preserves the normal blood flow pattern for varicocele treatment. Read More

Eur Rev Med Pharmacol Sci 2022 May;26(10):3745-3750

Health Sciences University, Adana City Training and Research Hospital Urology Clinic, Adana, Turkey.

Objective: We aimed to predict the potential testicular damage of COVID-19 by comparing the hormones FSH, LH, and TT before COVID-19 with values measured after COVID-19.

Patients And Methods: A total of 348 patients - who were followed up in our urology clinic for varicocele, premature ejaculation, erectile dysfunction and infertility, had FSH, LH and TT levels measured one year before COVID-19 and were positive for COVID-19 after a Polymerase Chain Reaction (RT-PCR) tests - were included in the study. Presence of pneumonia compatible with COVID-19, hospitalization in the intensive care unit and FSH, LH and TT values before and after COVID-19 were recorded, along with lung computed tomography (CT). Read More

Adv Exp Med Biol 2022 ;1358:205-235

S. H. Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, Hong Kong.

Despite being regarded as one of the most common causes of male subfertility, the pathophysiology of varicocele remains largely unknown. Recently, oxidative stress (OS) is proposed to be the mediator in how varicocele may negatively impact fertility. The imbalance of reactive oxygen species (ROS) and seminal antioxidants results in damage to sperm DNA and lipid membrane. Read More

Adv Exp Med Biol 2022 ;1358:41-62

Department of Life Science and Bioinformatics, Assam University, Silchar, India.

Reactive oxygen species (ROS) are free radicals that have at least one unpaired electron and play specific roles in the human body. An imbalance of ROS and antioxidant levels gives rise to a condition called oxidative stress. High levels of ROS in the male reproductive tract can interfere with its normal functioning and can even pose as toxic to the sperm, inhibiting sperm functioning (including motility) and metabolism. Read More

Adv Exp Med Biol 2022 ;1358:9-40

Department of Life Science and Bioinformatics, Assam University, Silchar, India.

Reactive oxygen species (ROS) are oxygen-containing molecules which are reactive in nature and are capable of independent existence in the body. ROS comprise mostly of free radicals that contain at least one unpaired electron. Endogenous sources are the foremost birthplaces of ROS, which include mitochondrial electron transport chain, endoplasmic reticulum and peroxisome. Read More

Basic Clin Androl 2022 May 30;32(1). Epub 2022 May 30.

Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.

Background: Infertility related to varicocele, infections, metabolic dysfunctions, oxidative stress and environmental toxicants is also associated with inflammatory processes that ultimately lead to the activation of the inflammasome pathway (IP). IP is classically activated by DAMPs, MAMPs or LAMPs, which stand for Damage-, Microbe- or Lifestyle-Associated Molecular Patterns, respectively. The most important player in IP activation is the NLRP3 (NOD[Nuclear oligomerization domain]-, LRR[Leucine rich repeat]- and pyrin domain-containing protein 3) which functions as an intracellular sensor of D/M/L-AMPs resulting in activation of caspase-1, promotion of apoptosis, pyroptosis and generation of inflammatory cytokines. Read More

Andrologia 2022 May 27:e14484. Epub 2022 May 27.

Department of Ultrasound, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

To analyse spermatic vein parameters and post-varicocelectomy diagnostic ultrasound methods by comparing pre- and post-operative ultrasound parameters and semen quality in patients undergoing varicocelectomy. Ultrasound and semen analyses were performed within 1 week before surgery and 3 months after surgery in 125 patients who underwent varicocelectomy for infertility. Patients were divided into three groups according to the post-operative internal diameter of the spermatic vein and reflux: recovery, dilatation, and reflux. Read More

J Minim Invasive Surg 2021 Jun;24(2):98-103

Department of Surgery, Kyung Hee University Hospital at Gangdong, Seoul, Korea.

Purpose: The aim of this study was to compare the short-term outcomes of two-dimensional (2D) and three-dimensional (3D) laparoscopic surgery for total extraperitoneal (TEP) primary inguinal hernia repair.

Methods: This was a single-center, retrospective, observational database study of 38 patients who underwent laparoscopic TEP inguinal hernia repair from March 1, 2019 to August 30, 2019 at Kyung Hee University Hospital at Gangdong in Seoul, Korea.

Results: There was no significant difference in sex ratio, age, or body mass index between the two groups. Read More

Food Sci Nutr 2022 May 25;10(5):1469-1480. Epub 2022 Mar 25.

Department of Clinical Sciences Faculty of Veterinary Medicine University of Tabriz Tabriz Iran.

Varicocele is considered the main reason for male infertility. Antioxidants are common drugs used to reduce the complications of varicocele in these patients. So, we investigated the effects of lycopene on sperm quality, testicular histology, and the expression of some genes in experimentally induced varicocele. Read More

Minerva Surg 2022 May 16. Epub 2022 May 16.

Operating Room, Shengjing Hospital affiliated to China Medical University, Shenyang, China -

Int J Mol Sci 2022 May 7;23(9). Epub 2022 May 7.

Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy.

Varicocele (VC) is the most common abnormality identified in men evaluated for hypofertility. Increased levels of reactive oxygen species (ROS) and reduced antioxidants concentrations are key contributors in varicocele-mediated hypofertility. Moreover, inflammation and alterations in testicular immunity negatively impact male fertility. Read More

Curr Vasc Pharmacol 2022 May 10. Epub 2022 May 10.

University of Chile. Physiology & Biophysics Program, ICBM. Faculty of Medicine. Av. Independencia 1027, Santiago, Chile.

Background: Testicular aches have been reported to occur on exposure to high altitude (HA). As a painful expression of venous congestion at the pampiniform plexus, varicocele (VC) might be a consequence of cardiovascular adjustments at HA. Chile's National Social Security Regulatory Body (SUSESO) asked to evaluate this condition in the running follow-up study "Health effects of exposure to chronic intermittent hypoxia in Chilean mining workers. Read More

Medicine (Baltimore) 2022 Apr 29;101(17):e29193. Epub 2022 Apr 29.

Department of Urology, Genesis Private Hospital, Diyarbakir, Turkey.

Abstract: Although many studies suggest that varicocelectomy leads to improvement in semen parameters and morphology, its clinical efficacy remains controversial. The detailed morphological parameters described in the World Health Organization guidelines are important in terms of showing the effect of microsurgical subinguinal varicocelectomy on morphological changes.An observational, retrospective clinical cohort study was conducted with patients followed up from January 2018 to August 2021. Read More

Eur J Transl Myol 2022 May 2. Epub 2022 May 2.

Shahid Beheshti University of Medical Sciences, Tehran.

The objective of this study was to evaluate inflammatory markers as predictors of fertility after varicocelectomy and to develop a prediction model. This prospective cohort was conducted on patients with varicoceles who were presented to the clinic of Imam Reza hospital of Tehran during 2019-2020. Semen analysis, complete blood count (CBC), and scrotal ultrasonography was requested. Read More

Int J Urol 2022 Apr 28. Epub 2022 Apr 28.

National Research Institute for Family Planning, Beijing, China.

Objectives: To explore the relationship between body mass index and varicocele, the range of body mass index that leads to increased odds of varicocele, and the association between body mass index with the position and grade of varicocele.

Methods: We conducted a cross-sectional study of 211 989 Chinese males aged 18-65 years participated in the National Free Pre-conception Check-up Projects from January 2013 to December 2018. Univariate and multivariate logistic regression models were constructed to assess the association between body mass index and varicocele. Read More

Hong Kong Med J 2022 04;28(2):181.e1-181.e2

Private Practice.

Urology 2022 Apr 21. Epub 2022 Apr 21.

AYTU Biosciences, Englewood, CO.

Objective: To assess whether varicocele repair improves oxidative stress (OS) measured by the MiOXSYS system.

Methods: A prospective clinical trial was performed on male patients ages 18 and older who had not fathered a child within the previous 12 months, with a clinically palpable varicocele, who completed all aspects of the study who were enrolled through a couple's fertility center with on-site andrology laboratory testing. Men that met inclusion criteria were offered enrollment in the clinical trial and signed informed consents to participate, after having a history and physical examination. Read More

Beijing Da Xue Xue Bao Yi Xue Ban 2022 Apr;54(2):294-298

Department of Urology, Andrology Center, Peking University First Hospital, Beijing 100034, China.

Objective: Androgen deficiency is common in aging males and may have unfavourable health consequences. Large-scale studies suggested low testosterone level might increse mortality and morbidity in ageing males. However, young men with low testosterone level might be neglected. Read More

Front Genet 2022 23;13:850114. Epub 2022 Mar 23.

School of Life Science, Bengbu Medical College, Bengbu, China.

According to the official statistics of the World Health Organization, at least 48 million couples and 186 million people suffer from infertility. Varicocele has been recognized as the leading cause of male infertility and can affect spermatogenesis and cause testicular and epididymal disorders through multiple diverse pathophysiological processes. Reactive oxygen species (ROS) produced by oxidative stress have been reconciled as an important pathogenic factor throughout the course of varicocele. Read More

Asian J Androl 2022 Mar 29. Epub 2022 Mar 29.

Department of Urology and Andrology, Faculty of Fundamental Medicine, Lomonosov Moscow State University, Moscow 119991, Russia.

In this review, we tried to systematize all the evidence (from PubMed [MEDLINE], Scopus, Cochrane Library, EBSCO, Embase, and Google Scholar) from 1993 to 2021 on the predictors of microsurgical varicocelectomy efficacy in male infertility treatment. Regarding the outcomes of varicocele repair, we considered semen improvement and pregnancy and analyzed them separately. Based on the 2011 Oxford CEBM Levels of Evidence, we assigned a score to each trial that studied the role of the predictor. Read More

J Inflamm Res 2022 26;15:2019-2031. Epub 2022 Mar 26.

Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.

Purpose: Omentin-1/intelectin (ITLN)1 is an adipocytokine with both anti-inflammatory and anti-oxidative stress properties, and little is known about its role in male reproduction. This study was aimed at exploring the relationships among omentin-1/ITLN1, semen parameters and F-isoprostanes (F-IsoPs), a maker of oxidative stress, in groups of patients affected by different pathologies. In addition, omentin-1/ITLN1 immunolocalization was assessed in ejaculated spermatozoa and in tissues of male reproductive system. Read More

Pathophysiology 2021 Oct 15;28(4):471-488. Epub 2021 Oct 15.

Laboratory of the Mosaics of Autoimmunity, Saint Petersburg State University, 199304 Saint Petersburg, Russia.

According to global data, there is a male reproductive potential decrease. Pathogenesis of male infertility is often associated with autoimmunity towards sperm antigens essential for fertilization. Antisperm autoantibodies (ASAs) have immobilizing and cytotoxic properties, impairing spermatogenesis, causing sperm agglutination, altering spermatozoa motility and acrosomal reaction, and thus preventing ovum fertilization. Read More

Int J Surg Case Rep 2022 Apr 28;93:106959. Epub 2022 Mar 28.

Department of Radiology, Mogadishu Somalia Turkish Training and Research Hospital, Somalia.

Introduction And Importance: Cystic scrotal lymphangiomas are very uncommon lesions caused by congenital lymphatic malformation. These tumors are usually located in the neck and axilla, occasionally in the mediastinum, retroperitoneum, and thigh. The scrotum and perineum are the least frequented sites. Read More