5,278 results match your criteria Varicocele


[Efficacy and safety study of microsurgical varicocelectomy in the treatment of non-obstructive azoospermia with varicocele].

Zhonghua Yi Xue Za Zhi 2018 Dec;98(46):3737-3740

Department of Urology, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai 200080, China.

To discuss the efficacy and safety of subinguinal microsurgical varicocelectomy in the treatment of non-obstructive azoospermia (NOA) with varicocele. The clinical data of 141 patients with NOA and varicocele who underwent subinguinal microsurgical varicocelectomy from March 2015 to June 2017 in Shanghai General Hospital was collected.One hundred and ten patients suffered from varicocele on the left side, 1 on the right side, and the rest (30 cases) were bilateral varicocele. Read More

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December 2018

Artificial Neural Network to Predict Varicocele Impact on Male Fertility through Testicular Endocannabinoid Gene Expression Profiles.

Biomed Res Int 2018 13;2018:3591086. Epub 2018 Nov 13.

Faculty of Biosciences and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy.

The relationship between varicocele and fertility has always been a matter of debate because of the absence of predictive clinical indicators or molecular markers able to define the severity of this disease. Even though accumulated evidence demonstrated that the endocannabinoid system (ECS) plays a central role in male reproductive biology, particularly in the testicular compartment, to date no data point to a role for ECS in the etiopathogenesis of varicocele. Therefore, the present research has been designed to investigate the relationship between testicular ECS gene expression and fertility, using a validated animal model of experimental varicocele (VAR), taking advantage of traditional statistical approaches and artificial neural network (ANN). Read More

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November 2018
2 Reads

Effects of Varicocele Treatment on Sperm Conventional Parameters: Surgical Varicocelectomy Versus Sclerotherapy.

Cardiovasc Intervent Radiol 2018 Dec 5. Epub 2018 Dec 5.

Department of Clinical and Experimental Medicine, University of Catania, Via S. Sofia 78, 95123, Catania, Italy.

Introduction: Varicocele is often associated with impaired sperm parameters. Different procedures have been developed for varicocele treatment. The aim of this study was to evaluate the effects of varicocele treatment on conventional sperm parameters. Read More

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December 2018
1 Read

The role of inheritance in the development of adolescent varicoceles.

Transl Androl Urol 2018 Dec;7(6):920-925

Smith Institute for Urology, Northwell Health, New Hyde Park, NY, USA.

Background: The prevalence of varicoceles is estimated to be 15% in the general population but is nearly 35% among men with primary infertility and increases by 10% with each decade of life. Studies among adults infer a higher rate of varicoceles among first-degree relatives of patients with varicoceles. However, these studies do not consider the presence of varicoceles, or other venous abnormalities, at the time of desired paternity in first-degree relatives of adolescent patients. Read More

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December 2018
1 Read

Complete urological evaluation including sperm DNA fragmentation in male systemic lupus erythematosus patients.

Lupus 2018 Dec 3:961203318815764. Epub 2018 Dec 3.

1 Discipline of Urology, Hospital das Clinicas HCFMUSP, Sao Paulo, Brazil.

Objective: To evaluate sperm DNA fragmentation analysis in non-azoospermic male systemic lupus erythematosus (SLE) patients.

Methods: Twenty-eight consecutive male SLE patients (American College of Rheumatology criteria) and 34 healthy controls were evaluated for demographic/exposures data, urological evaluation, hormone profile and sperm analysis (including sperm DNA fragmentation). Clinical features, disease activity/damage scores and treatment were also evaluated. Read More

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December 2018
1 Read

Fertility in males after childhood, adolescent, and adult inguinal operations.

J Pediatr Surg 2018 Oct 5. Epub 2018 Oct 5.

Department of Pediatric Surgery, University Medicine of the Johannes Gutenberg University, Mainz, Germany. Electronic address:

Background/purpose: Inguinal hernia repair and orchidopexy are among the most common operations in boys. The impact on future fertility has not been conclusively defined. This study evaluates sperm quality after previous inguinal surgery. Read More

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October 2018
2 Reads

Polymorphisms of sperm protamine genes and CMA3 staining in infertile men with varicocele.

Rev Int Androl 2018 Nov 24. Epub 2018 Nov 24.

Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address:

Objectives: The aim of this study was to evaluate polymorphisms of sperm protamine genes and their effects on the result of CMA3 staining in varicocele men.

Material And Methods: In a case control study, 128 patients with male infertility due to varicocele and 128 controls were recruited. Polymorphisms of PRM1 and PRM2 genes in extracted DNA samples were assessed by PCR-SSCP and sequencing. Read More

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November 2018
3 Reads

Hypoxia pathway has more impact than inflammation pathway on etiology of infertile men with varicocele.

Andrologia 2018 Nov 26:e13189. Epub 2018 Nov 26.

Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.

This study aimed to compare main molecular markers of hypoxia (HIF1-α and P53) and inflammation (TLR-2, TLR-4 and TNF-α) pathways between infertile men with varicocele and fertile individuals. Sperm parameters such as sperm concentration, motility and morphology were assessed according to World Health Organization (Laboratory manual for the examination and processing of human semen. Geneva, Switzerland, 2010) guideline in 20 infertile men with grade II or III varicocele, and 20 fertile men candidate of family balancing. Read More

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November 2018

Evaluation of Oxidative Stress in Testis and Sperm of Rat Following Induced Varicocele.

Urol J 2018 Nov 21. Epub 2018 Nov 21.

Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.

Purpose: Oxidative stress (OS) plays a central role in the pathophysiology of varicocele (VC), however, comprehensive studies concomitantly assessing semen parameter along with chromatin status, oxidative stress, and enzymatic antioxidants in both testis and sperm are limited. Therefore, this study aims to assess these parameters in varicocelized rats.

Materials And Methods: For this study, 30 Wistar rats were randomly divided into three groups: Control group (I); sham-operated group (II) and left varicocele group (III). Read More

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November 2018
5 Reads

Case 36-2018: A 29-Year-Old Man with an Incidentally Discovered Renal Mass.

N Engl J Med 2018 11;379(21):2064-2072

From the Departments of Urology (D.M.D.), Radiology (J.F.S.), Medicine (O.I., P.J.S.), and Pathology (C.-L.W.), Massachusetts General Hospital, and the Departments of Surgery (D.M.D.), Radiology (J.F.S.), Medicine (O.I., P.J.S.), and Pathology (C.-L.W.), Harvard Medical School - both in Boston.

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November 2018
7 Reads

The use of diffusion-weighted MR imaging in the functional assessment of the testes of patients with clinical varicocele.

Andrologia 2018 Nov 20:e13197. Epub 2018 Nov 20.

Diagnostic and Interventional Radiology Department, Cairo University Hospitals, Cairo, Egypt.

We aimed to evaluate the use of diffusion-weighted imaging (DWI) in the assessment of the varicocele effect on testicular parenchyma and spermatogenesis, with estimation of apparent diffusion coefficient (ADC) value changes in the testicular parenchyma. We prospectively evaluated 30 consecutive patients (18 patients with bilateral varicocele and 12 patients with unilateral varicocele) and 10 healthy controls. US and DWI were performed to all patients. Read More

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November 2018
6 Reads

Pattern of varicocele vein blood gases in patients undergoing microsurgical Varicocelectomy.

BMC Urol 2018 Nov 13;18(1):104. Epub 2018 Nov 13.

Department of Physiology, University of Veterinary and Animal Sciences, Lahore, Pakistan.

Background: Varicocele is known to be associated with infertility and sperm disorders. The exact cause of this ailment is not fully understood. There are limited numbers of studies where venous blood gases (VBGs) of varicocele veins were determined with conflicting results. Read More

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November 2018
3 Reads

[Aneurisma de arteria testicular: reporte de un caso y revisión de la literatura].

Bol Med Hosp Infant Mex 2018 ;75(6):373-376

Departamento de Enseñanza e Investigación, Hospital General Regional Número Uno, Instituto Mexicano del Seguro Social. Ciudad Obregón, Sonora, México.

Background: Aneurysm of the testicular artery is a rare entity; the term is described as the dilation of any blood vessel in the body.

Case Report: An 18-year-old patient with a left testicular artery aneurysm, with no family or personal history of medical importance, presented for consultation due to a volume increase of long evolution in the inguinal region, accompanied by sporadic pain with no other symptoms. The testicular artery aneurysm was not detectable preoperatively by ultrasound, which only reported data compatible with left inguinal hernia and varicocele. Read More

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January 2018
1 Read

Adult presentation of asymptomatic right lung agenesis: a rare anatomical variation.

Surg Radiol Anat 2018 Nov 7. Epub 2018 Nov 7.

Chest Medicine Department, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Pulmonary agenesis is a very rare congenital anomaly characterized by the absence of pulmonary parenchyma and its vasculature. The diagnosis is usually during childhood. Herein, we report a case of incidental discover right pulmonary agenesis in adulthood male. Read More

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November 2018
6 Reads

An examination on composition of spermatozoa obtained from pre-operative and post-operative varicocele patients.

Reprod Biol 2018 Nov 2. Epub 2018 Nov 2.

Department of Histology and Embryology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.

Varicocele is one of the main and surgically repairable causes of male infertility, which arises from dilatation and torsion of the testicular veins in the plexus pampiniformis. In this study, we examined semen samples from 40 patients diagnosed with varicocele between the ages of 15 and 30 years, according to WHO criteria (pre-operatively, and at 3, 6, and 12 months post-operatively). The mean spermatozoa concentration was found to be 45. Read More

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November 2018
10 Reads

Effects of medical comorbidity on male infertility and comorbidity treatment on spermatogenesis.

Fertil Steril 2018 Nov;110(6):1006-1011.e2

Department of Urology, Yamaguchi University School of Medicine, Ube, Japan.

Objective: To investigate the prevalence and effects of medical comorbidities on spermatogenesis and to determine whether the treatment of medical comorbidities effectively improves spermatogenesis.

Design: Single-center case-control study.

Setting: University hospital. Read More

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November 2018
11 Reads

Ultrasensitive Doppler as a tool for the diagnosis of testicular ischemia during the Valsalva maneuver: a new way to explore varicoceles?

Acta Radiol 2018 Nov 5:284185118810981. Epub 2018 Nov 5.

3 Institut Langevin, ESPCI Paris, PSL Research University, Paris, France.

Background: Varicocele is among the most common causes of male infertility because of various mechanism, including hypoxia.

Purpose: To evaluate testicular vascularization (TV) with ultrasensitive Doppler before and during the Valsalva maneuver (VM) and correlate TV changes to varicocele's spermatic venous reflux graduated by color Doppler.

Material And Methods: From January to February 2016, 69 men (135 testis) referred for scrotal ultrasound were prospectively enrolled. Read More

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November 2018
5 Reads

Regulation of anti-Müllerian hormone (AMH) in males and the associations of serum AMH with the disorders of male fertility.

Asian J Androl 2018 Oct 26. Epub 2018 Oct 26.

Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.

Anti-Müllerian hormone (AMH) is a functional marker of fetal Sertoli cells. The germ cell number in adults depends on the number of Sertoli cells produced during perinatal development. Recently, AMH has received increasing attention in research of disorders related to male fertility. Read More

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October 2018
6 Reads

Hypogonadism is independently associated with varicocele repair in a contemporary cohort of men in the USA.

Asian J Androl 2018 Oct 26. Epub 2018 Oct 26.

Department of Urology, Emory University School of Medicine, Atlanta, GA 30322, USA.

We aimed to identify demographic and clinical predictors of varicocele repair in a contemporary cohort of men in the USA. We queried the 2009-2015 MarketScan Database using relevant ICD9, ICD10, and CPT codes to identify all 18-45 year olds with varicoceles. Differences in age, area of residence, clinical characteristics, and medical management between men who did and did not undergo varicocelectomy (open, laparoscopic, or microsurgical) during the study period were compared using unpaired t-tests and Chi-squared tests for continuous and categorical variables, respectively. Read More

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October 2018
1 Read

Varicocele repair in patients prepared for intracytoplasmic sperm injection: To do or not to do?

Andrologia 2018 Oct 29:e13185. Epub 2018 Oct 29.

Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Purpose: This study sought to evaluate the impact of varicocele repair on intracytoplasmic sperm injection outcomes.

Patients And Methods: A prospective comparative study was conducted at the Assisted Reproduction Unit, International Islamic Center for Population Studies and Researches, Al-Azhar University. This study included 100 non-azoospermic infertile men with a history of varicocele who were scheduled for intracytoplasmic sperm injection, half of them had already undergone prior subinguinal varicocelectomy at least 12 months prior to ICSI without clinically evident recurrence (treated group 1), and the other half has any grade of an unrepaired clinical varicocele (untreated group 2) at sperm injection. Read More

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October 2018
6 Reads

Evaluation of sperm DNA fragmentation index, Zinc concentration and seminal parameters from infertile men with varicocele.

Andrologia 2018 Oct 28:e13184. Epub 2018 Oct 28.

Department of Biology and Medical Genetic, Hanoi Medical University, Hanoi, Vietnam.

The aim of this study was to investigate the effect of varicocele on DNA fragmentation index (DFI), zinc concentration and seminal parameters in infertile patients. In this prospective study, 179 men with at least 1-year history of infertility and varicocele were examined for semen quality at Hanoi Medical University Hospital (HMUH), Hanoi, Vietnam. In addition, an inverse correlation between zinc concentration and the degree of sperm DNA fragmentation in patients with clinical varicocele was found. Read More

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October 2018
8 Reads

Expression of claudin‑11 in a rat model of varicocele and its effects on the blood‑testis barrier.

Mol Med Rep 2018 Dec 26;18(6):5647-5651. Epub 2018 Oct 26.

Department of Urology, Shaoxing People's Hospital (Shaoxing Hospital of Zhejiang University School of Medicine), Shaoxing, Zhejiang 312000, P.R. China.

Varicocele (VC) is an abnormal tortuosity and venous distension of the pampiniform plexus in the spermatic cord. VC is the most common surgically correctable cause of male infertility. The purpose of the present study was to investigate the effects of VC on the tight junctions and the blood‑testis barrier (BTB) of Sertoli cells in the bilateral testes of rats. Read More

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December 2018
4 Reads

Adolescence and andrologist: An imperfect couple.

Arch Ital Urol Androl 2018 Sep 30;90(3):208-211. Epub 2018 Sep 30.

Andrology Unit, Department of Clinical and Molecular Medicine, Sant'Andrea Hospital, University of Rome "Sapienza", Rome.

Objective: The aims of this research were to study: a) the prevalence of male adolescents, aged between 10 and 19 years of age, referred to our Unit for an andrological assessment; b) the reasons (stated and subsequently modified) for referral; c) the prevalence of clinically diagnosed diseases.

Materials And Methods: A total of 2.855 subjects, referred to the Andrology Unit for a first examination, were retrospectively studied. Read More

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September 2018
1 Read

An Infertile Couple's Long and Expensive Path to Varicocele Repairs.

Urology 2018 Oct 22. Epub 2018 Oct 22.

Center for Reproductive Medicine, Scott Department of Urology, Baylor College of Medicine, Houston, TX.

Objective: To characterize the pathways to care that infertile couples requiring varicocele repair (VR) pursue prior to presenting to a male fertility clinic.

Methods: An IRB-approved single center retrospective review of patients undergoing VR after presentation to an academic male fertility clinic was performed. Patients whose charts included partner histories were assessed for duration of attempting conception, prior workup, and assisted reproductive technology (ART) use. Read More

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October 2018
5 Reads

Comparison of the clinical characteristics of patients with varicocele according to the presence or absence of scrotal pain.

Andrologia 2018 Oct 25:e13187. Epub 2018 Oct 25.

Department of Urology, Pusan National University School of Medicine, Busan, Korea.

We investigated the clinical characteristics of patients with varicocele according to the presence or absence of scrotal pain. We retrospectively reviewed the records of patients who underwent varicocelectomy. The age, body mass index, grade, laterality of varicocele, testicular volume difference, time to hospital visit, serum testosterone level and semen parameters were evaluated. Read More

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October 2018
2 Reads

Cysteine-rich secretory protein 3: inflammation role in adult varicocoele.

Andrology 2018 Oct 24. Epub 2018 Oct 24.

Department of Surgery, Division of Urology, Universidade Federal de São Paulo, São Paulo, Brazil.

Background: Cysteine-rich secretory protein (CRISP-3), a protein involved in inflammatory response, is highly increased in seminal plasma of adolescents with varicocoele and altered semen analysis, but not in adolescents with varicocoele and normal semen. It is not known, however, whether this increased seminal concentration occurs as an acute marker during the initial stages of varicocoele or whether this persists as an altered protein pathway.

Objective: The purpose of this study, thus, was to test the hypothesis that this inflammatory state persists through adulthood and the correction of varicocoele could correct this state, by identifying the levels of CRISP-3 in seminal plasma. Read More

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October 2018
5 Reads

The clinical usefulness of a novel grading system for varicocoeles using duplex Doppler ultrasound examination based on postsurgical modifications of seminal parameters.

Andrology 2018 Oct 24. Epub 2018 Oct 24.

Andrology and IVF Department, Clinica San Carlo, Paderno Dugnano (Milano), Italy.

Background: The existing classifications of varicocoeles have poor predictive value regarding the effects of surgery on sperm count.

Objective: To develop a new grading system for varicocoeles, useful as an indication for surgery.

Materials And Methods: This is a three-center prospective study which examined 173 men having clinically detectable left varicocoeles and oligo ± astheno ± terato-spermia. Read More

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October 2018
3 Reads

Comparison of main molecular markers involved in autophagy and apoptosis pathways between spermatozoa of infertile men with varicocele and fertile individuals.

Andrologia 2018 Oct 23:e13177. Epub 2018 Oct 23.

Department of Reproductive Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.

Abnormal dilatation and tortuosity of the pampiniform plexus within the spermatic cord are termed varicocele which leads to impaired spermatogenesis due to heat-related oxidative stress and cell death. Previously, it was shown that both apoptosis and autophagy pathways were activated by heat in germ cells of mouse in vivo and in vitro. But, status of these pathways is not clear in chronic state of heat stress such as varicocele. Read More

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October 2018
3 Reads

Microsurgery Versus Laparoscopic Surgery for Varicocele: A Meta-Analysis and Systematic Review of Randomized Controlled Trials.

J Invest Surg 2018 Oct 19:1-9. Epub 2018 Oct 19.

a Department of Urology , Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College , Beijing , China.

Background: The goal of this meta-analysis and systematic review is to evaluate the overall effect and safety of microsurgery versus laparoscopic surgery in the treatment of varicocele according to qualified randomized controlled trials (RCTs).

Methods: The following electronic databases were searched including PubMed, Cochrane, Embase to identify the qualified studies and publications that were associated with this meta-analysis updated to February 2018 based on index words. The qualified studies only included RCTs. Read More

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October 2018
12 Reads

Selecting patients for embolization of varicoceles based on ultrasonography.

J Ultrason 2018 ;18(73):90-95

Department of Interventional Radiology and Neuroradiology, Medical University of Lublin, Lublin, Poland.

Aim: The aim of the study was to assess patient selection for embolization of varicoceles based on ultrasonography. An additional objective of the work was to evaluate the results of endovascular treatment.

Material And Methods: From January 2015 till August 2017, 53 patients with varicoceles diagnosed in an ultrasound examination underwent endovascular treatment in the Department of Interventional Radiology and Neuroradiology in Lublin, Poland. Read More

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January 2018
7 Reads

Berberine ameliorates experimental varicocele-induced damages at testis and sperm levels; evidences for oxidative stress and inflammation.

Andrologia 2018 Oct 17:e13179. Epub 2018 Oct 17.

Gametogenesis Research Center, Kashan University of Medical Sciences, Kashan, Iran.

The present study was performed to show the ameliorative effect of berberine (BBR), as an antioxidant and anti-inflammatory agent, against experimental varicocele (VCL)-induced molecular and histological damages. For this purpose, 50 mature Wistar rats were divided into control, control-sham, VCL-sole, 50 mg/kg and 100 mg/kg BBR-treated VCL-induced groups. The tissue levels of interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α), nitric oxide (NO), total antioxidant capacity (TAC), malondialdehyde (MDA), superoxide dismutase (SOD) and gluthatione peroxidase (GSH-px) as well as the mRNA levels of testicular CuZn SOD, MnSOD, EC-SOD and GSH-px were evaluated. Read More

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October 2018
9 Reads

Clinical grading and color Doppler ultrasonography-based grading of varicocele: how compatible are the two grading systems?

World J Urol 2018 Oct 15. Epub 2018 Oct 15.

Department of Urology, Urology Oncology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Objective: Inhere, we compared two of the most common grading systems based on color Doppler ultrasonography (CDU) and physical examination in patients suspected of varicocele.

Methods: This is a cross-sectional study. Overall, 66 patients clinically suspected of varicocele were visited by an attending urologist and a radiologist for physical examination and CDU. Read More

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October 2018
8 Reads

Effects of varicocele on testicles: Value of strain elastography: A prospective controlled study.

Andrologia 2018 Oct 14:e13161. Epub 2018 Oct 14.

Samsun Training and Research Hospital Urology Clinic, University of Health Sciences, Samsun, Turkey.

The aim of this study was to evaluate the structural changes in testicles of the patients with varicocele by strain elastography (SE) and to identify the relationship between semen analysis and hormone levels considering SE results. The patients were separated into two groups as varicocele and control, according to their physical examination and the scrotal colour duplex ultrasonography results. All patients underwent examination by hormonal profile, semen analysis, colour duplex ultrasonography and sonoelastography. Read More

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October 2018
1 Read

Varicocele Repair Versus Testosterone Therapy for Older Hypogonadal Men with Clinical Varicocele and Low Testosterone.

Eur Urol Focus 2018 04 11;4(3):314-316. Epub 2018 Oct 11.

Department of Urology and Center for Male Reproductive Medicine and Surgery, Weill Cornell Medical College, New York, NY, USA.

As men age, serum testosterone levels decrease. This reduction in testosterone levels may cause symptoms leading to hypogonadism. In addition, the presence of a varicocele can impair Leydig cell function, resulting in decreased testosterone production in men. Read More

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April 2018
4 Reads

Treatment of Varicocele in Children and Adolescents: A Systematic Review and Meta-analysis from the European Association of Urology/European Society for Paediatric Urology Guidelines Panel.

Eur Urol 2018 Oct 10. Epub 2018 Oct 10.

Department of Pediatric, Adolescent and Reconstructive Urology, University of Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Context: The benefits and harms of intervention (surgical or radiological) versus observation in children and adolescents with varicocele are controversial.

Objective: To systematically evaluate the evidence regarding the short- and long-term outcomes of varicocele treatment in children and adolescents.

Evidence Acquisition: A systematic review and meta-analysis was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) statement. Read More

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October 2018
2 Reads

Pros and cons of robotic microsurgery as an appropriate approach to male reproductive surgery for vasectomy reversal and varicocele repair.

Fertil Steril 2018 Oct;110(5):816-823

Division of Urology, Alpert Medical School of Brown University, Providence, Rhode Island; Lifespan, Providence, Rhode Island. Electronic address:

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October 2018
11 Reads

Fertility Issues in Pediatric Urology.

Urol Clin North Am 2018 Nov 7;45(4):587-599. Epub 2018 Sep 7.

Division of Urology, Seattle Children's Hospital, 4800 Sand Point Way Northeast, OA.9.220, Seattle, WA 98105, USA.

Improved understanding of the pathogenesis and natural history of many urologic disorders, as well as advances in fertility preservation techniques, has increased the awareness of and options for management of fertility threats in pediatric patients. In children, fertility may be altered by oncologic conditions, by differences in sexual differentiation, by gonadotoxic drugs and other side effects of treatment for nonurologic disorders, and by urologic conditions, such as varicocele and cryptorchidism. Although fertility concerns are best addressed in a multidisciplinary setting, pediatric urologists should be aware of the underlying pathophysiology and management options to properly counsel and advocate for patients. Read More

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November 2018
1 Read

Varicocelectomy May Improve Results for Sperm Retrieval and Pregnancy Rate in Non-Obstructive Azoospermic Men.

Int J Fertil Steril 2019 Jan 2;12(4):303-305. Epub 2018 Oct 2.

Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.

Background: Assessing the net-results of microsurgical varicocelectomy in infertile men with non-obstructive azoospermic (NOA) and clinical varicocele in five years at Royan Institute.

Materials And Methods: This is a descriptive retrospective cohort study. A backward-looking review of patients treated for NOA and varicocele from march 2011 to march 2016 was performed. Read More

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January 2019
7 Reads

The relationship between inflammation and mean platelet volume in varicocele pathophysiology.

Rev Int Androl 2018 Oct - Dec;16(4):137-142. Epub 2017 Oct 17.

Department of Radiology, Eskisehir Military Hospital, Eskisehir, Turkey.

Introduction: The mean platelet volume (MPV) is an extensively employed laboratory indicator related to platelet volume and function in inflammatory circumstances. The aim of this study was to assess the relationship between inflammation and mean platelet volume in varicocele pathophysiology.

Methods: We conducted a recent study, which included 131 varicocele subjects and 82 healthy controls. Read More

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October 2017
14 Reads

Treating varicocele in 2018: current knowledge and treatment options.

J Endocrinol Invest 2018 Dec 3;41(12):1365-1375. Epub 2018 Oct 3.

Division of Endocrinology, Diabetology and Metabolism, Department of Medical Sciences, University of Turin, Corso Dogliotti 14, 10126, Turin, Italy.

Purpose: Varicocele is defined as a state of varicosity and tortuosity of the pampiniform plexus around the testis caused by retrograde blood flow through the internal spermatic vein. The prevalence of clinically relevant varicocele ranges from 5 to 20% in the male population and is often associated with infertility and reduction of sperm quality. In this review, the pathophysiology and clinical aspects of varicocele are reviewed along with therapeutic options and treatment effects on sperm parameters and fertility both in adult and in pediatric/adolescent subjects. Read More

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December 2018
34 Reads

Laparoscopic right varicocelectomy for chronic scrotal pain.

AME Case Rep 2018 20;2:37. Epub 2018 Jul 20.

Department of Urology, General Hospital of Rethymnon, Rethymnon, Greece.

Varicocele represents a common problem in young men with infertility or chronic scrotal pain and it is located on the left side in the vast majority of the cases. Right isolated varicocele is a quite rare entity, especially in middle-aged men and as the single pathology responsible for chronic pain. Further investigation might be needed to exclude other retroperitoneal or scrotal hidden lesions. Read More

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July 2018
2 Reads

The heritability of pampiniform plexus vessel size and varicocoele in boars.

Reprod Domest Anim 2018 Sep 24. Epub 2018 Sep 24.

Department of Animal Science, University of Nebraska-Lincoln, Lincoln, Nebraska.

Ultrasonography was used to capture a coronal-sagittal image of the veins of the pampiniform plexus (PP) and the testicular artery of 327 maternal-line boars at approximately 6 months of age at the University of Nebraska-Lincoln. Varicocoele was diagnosed by two methods. Method 1 diagnosed varicocoele when the average vessel area on one side of the scrotum was 1. Read More

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September 2018
2 Reads

Intravascular Ultrasound for Evaluation of Left Gonadal Vein Anatomic Variations During Coil Embolization.

J Ultrasound Med 2018 Sep 23. Epub 2018 Sep 23.

Radiology, University of Thessaly, Larisa, Greece.

We illustrate the intravascular ultrasound (US) findings in the evaluation of left gonadal vein anatomic variations. During a 2-year period, 4 consecutive patients (mean age, 37 years; range, 28-45 years) with left-sided varicocele underwent embolization. Intravascular US examinations and retrograde venography were performed to assess varicocele anatomy. Read More

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September 2018
2 Reads

A preliminary evaluation of serum level of testosterone, LH, and FSH in patients with varicocele after varicocelectomy as a kidney-related disease.

Ther Clin Risk Manag 2018 4;14:1585-1590. Epub 2018 Sep 4.

Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.

Introduction: Varicocele is a common problem with a high prevalence in population with primary and secondary infertilities. The adverse effects of varicocele on spermatogenesis and fertility are known, but the association between clinical varicocele and testosterone is not clear. Hence, we decided to evaluate the serum levels of testosterone, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in patients with varicocele after varicocelectomy. Read More

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September 2018
6 Reads

Paraneoplastic Phenomena in a Patient With Locally Destructive and Metastatic Renal Cell Carcinoma.

J Prim Care Community Health 2018 Jan-Dec;9:2150132718799023

1 Mayo Clinic., Kasson, MN, USA.

Renal cell carcinoma (RCC) accounts for approximately 80% of all primary renal neoplasms in United States causing approximately 65 000 new cases of RCC and 14 000 deaths each year. Symptoms of RCC typically include weight loss and night sweats but may also feature paraneoplastic phenomena in advanced stages as well as flank pain, gross hematuria, scrotal varicocele, inferior vena cava pathology, and a palpable abdominal mass. In this article, we present the course of a patient with advanced RCC, from initial presentation through workup and to eventual diagnosis. Read More

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September 2018

Dilating Vascular Diseases: Pathophysiology and Clinical Aspects.

Int J Vasc Med 2018 26;2018:9024278. Epub 2018 Aug 26.

Ankara Education and Research Hospital, Department of Cardiology, Ankara, Turkey.

Atherosclerotic disease of the vessels is a significant problem affecting mortality and morbidity all over the world. However, dilatation of the vessels either in the arterial system or in the venous territory is another vessel disease. Varicocele, pelvic, and peripheral varicose veins and hemorrhoids are aneurysms of the venous vascular regions and have been defined as dilating venous disease, recently. Read More

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August 2018
1 Read

Scrotal ultrasonographic findings in obese infertile patients and their correlations to semen and hormonal profile.

Turk J Urol 2018 Aug 31:1-5. Epub 2018 Aug 31.

Department of Urology, Sohag University Hospital, Sohag, Egypt.

Objective: The aim of this prospective study was to compare scrotal ultrasonographic findings in obese and normal weight infertile men and correlate these findings with semen parameters and hormonal profile.

Material And Methods: A total of 188 men presented for infertility evaluation were included in this study. They were divided according to body mass indices into obese (n=96) and normal weight infertile patients (n=92). Read More

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August 2018
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[Inhibin B level helps evaluate the testicular function of prepubertal patients with varicocele].

Zhonghua Nan Ke Xue 2018 Jul;24(7):618-621

Department of Urology, Huai'an First People's Hospital of Nanjing Medical University, Huai'an, Jiangsu 223300, China.

Objective: To investigate the role of the serum inhibin B (INHB) level in evaluating the testicular function of the prepubertal patient with varicocele (VC) after high ligation of the spermatic vein (HLSV).

Methods: This study included 31 prepubertal male patients with left VC, averaging 12.55 years of age and 9 complicated by right VC. Read More

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July 2018
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