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Medicine (Baltimore) 2023 Sep;102(38):e35170

Department of Urology, China Medical University Hospital, Taichung, Taiwan.

Varicocele is a major cause of male infertility. However, few studies have discussed the potential associations between the pain caused by varicocele and preoperative and intraoperative factors. The aim of this study was to evaluate factors potentially associated with changes in pain score after microsurgical varicocelectomy. Read More

Pan Afr Med J 2023 10;45:119. Epub 2023 Jul 10.

Maternal-Child and Mental Health Research Laboratory, Faculty of Medicine and Pharmacy, Mohammed First University, Oujda, Morocco.

Introduction: azoospermia affects more than 10%-15% of infertile male subjects attending the infertility center. In Morocco, there have been no studies on male infertility with azoospermia. Thereby, our objective was to evaluate the clinical, hormonal, and genetic characteristics of infertile men with azoospermia in Morocco. Read More

Int J Urol 2023 Sep 22. Epub 2023 Sep 22.

Department of Urology, Reproduction Center, Yokohama City University Medical Center, Kanagawa, Yokohama, Japan.

Approximately 1% of the general male population has azoospermia, and nonobstructive azoospermia accounts for the majority of cases. The causes vary widely, including chromosomal and genetic abnormalities, varicocele, drug-induced causes, and gonadotropin deficiency; however, the cause is often unknown. In azoospermia caused by hypogonadotropic hypogonadism, gonadotropin replacement therapy can be expected to produce sperm in the ejaculate. Read More

ACG Case Rep J 2023 Sep 20;10(9):e01155. Epub 2023 Sep 20.

Department of Gastroenterology and Hepatology, King Saud Medical City, Riyadh, Saudi Arabia.

Intragastric balloons (IGBs) are commonly used for weight loss by mechanically distending the stomach. We present a case of a 35-year-old man who developed a left-sided varicocele 1 week after IGB insertion. Imaging revealed splenic vein compression and possible thrombosis. Read More

Int J Reprod Biomed 2023 Aug 23;21(7):577-584. Epub 2023 Aug 23.

Department of Anatomy, School of Medicine, Arak University of Medical Sciences, Arak, Iran.

Background: Varicocele is characterized by abnormal dilation of the testicular vein, which results in hypoxia, the accumulation of reactive oxygen species, and the production of proinflammatory cytokines. It seems that a group of cytosolic receptors named nod-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome, is activated and involved in the pathogenesis of varicocele.

Objective: We aim to determine the time course of NLRP3 inflammasome expression in the testis tissue following varicocele induction. Read More

J Pediatr Surg 2023 Aug 18. Epub 2023 Aug 18.

Department of Urology, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA.

Background: Management of the adolescent varicocele focuses on optimizing fertility potential, but to date there is limited data on the success of varicocelectomy on optimizing semen parameters for individual adolescent patients. We reviewed our database of over 1600 adolescent varicocele patients to find those with pre- and postoperative semen analyses to determine the impact of varicocele correction.

Methods: 15 Tanner stage V patients with unilateral clinically apparent left-sided with pre- and postoperative semen analyses were identified. Read More

Urology 2023 Sep 11. Epub 2023 Sep 11.

Department of Urology, University of Minnesota, Minneapolis MN, USA.

Objective: To study whether varicocele repair would improve sperm capacitation and probability of generating a pregnancy.

Methods: Data were collected prospectively of 40 consecutive adult men who presented with infertility confirmed by semen analysis and found to have a varicocele on exam or ultrasound who underwent unilateral or bilateral subinguinal microscopic varicocelectomy. We recorded pre and post-operative SA, Cap-Score, and PGP with a 3-month follow up. Read More

Cureus 2023 Aug 12;15(8):e43376. Epub 2023 Aug 12.

Medical Genetics and Oncogenetics Laboratory, Central Laboratory of Medical Analysis, University Hospital Center Hassan II, Fez, MAR.

This case report focuses on a 33-year-old male patient with a history of infertility, characterized by severe micro-oligo-asthenospermia. Subsequent analysis revealed the presence of multi-headed and multi-flagellated spermatozoa, indicating a potential case of macrocephalic spermatozoa syndrome linked to a mutation in the gene. Genetic testing confirmed the presence of a pathogenic mutation, c. Read More

Am J Mens Health 2023 ;17(5):15579883231199400

Department of Urology, Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China.

Varicocele surgical repair can improve the function of the testis for patients with varicocele. We carried out a systematic review and meta-analysis to assess the effects of varicocele surgical repair on serum hormones and inhibin B levels in patients with varicocele. A literature search was performed in August 2022, and no language or geographic region restrictions were applied. Read More

Int J Mol Sci 2023 Aug 31;24(17). Epub 2023 Aug 31.

Department of Human Adult and Childhood Pathology, University of Messina, 98122 Messina, Italy.

Many natural substances commonly found in healthy diets have been studied for their potential to reduce male infertility associated with varicocele. A positive role of selenium (Se) or lycopene alone was demonstrated in experimental varicocele, while no data are available on their association. One group of male Sprague-Dawley rats was sham operated and daily treated with Se (3 mg/kg, i. Read More

Reprod Sci 2023 Sep 7. Epub 2023 Sep 7.

Urology/Pelvic Floor Surgery, West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.

As a rare disease leading to male infertility, idiopathic hypogonadotropic hypogonadism (IHH) has strong heterogeneity of clinical phenotype and gene mutation. At present, there is no effective diagnosis and treatment method for this disease. This study is to explore the possible new pathogenic gene of idiopathic hypogonadotrophic hypogonadism and the pathological mechanism affecting its occurrence. Read More

Niger Postgrad Med J 2023 ;30(3):218-225

Department of Surgery, College of Medicine, University of Lagos, Lagos, Nigeria.

Introduction: Varicocele is a treatable aetiology of male infertility. Magnification with surgical loupe has been associated with improved outcome and reduced morbidity than the conventional technique without magnification.

Objective: To compare the outcomes of two techniques of subinguinal varicocelectomy, with a surgical loupe and without. Read More

Cell Mol Biol Lett 2023 Sep 5;28(1):72. Epub 2023 Sep 5.

NHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Science Institute (Guangdong Provincial Fertility Hospital), Guangzhou, China.

Background: In recent years, N6-methyladenosine (mA) methylation modification of mRNA has been studied extensively. It has been reported that mA determines mRNA fate and participates in many cellular functions and reactions, including oxidative stress. The PLOD2 gene encodes a protein that plays a key role in tissue remodeling and fibrotic processes. Read More

Urol Ann 2023 16;15(3):256-260. Epub 2023 Jun 16.

Department of Surgery, Urology Section, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.

Objective: Varicocele, the dilation of the pampiniform plexus of the spermatic cord. It is discovered incidentally in most patients. Symptoms vary, but its impact is especially experienced in the field of fertility and reflected in semen parameters. Read More

Urol Ann 2023 17;15(3):311-314. Epub 2023 Jul 17.

Division of Urology, Department of Surgery, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia.

Introduction: Varicocelectomy is the prevailing management of scrotal pain secondary to varicocele. However, the literature is controversial on this topic. Some data showed that pain may persist after the surgery even if the varicocele is not detected postoperatively. Read More

Sultan Qaboos Univ Med J 2023 Aug 28;23(3):397-399. Epub 2023 Aug 28.

Department of Medical Imaging, King Khalid University Hospital, Riyadh, Saudi Arabia.

Arteriovenous malformations (AVMs) are benign vascular lesions. Although, the majority of AVMs occur in the central nervous system, there are published reports of AVMs involving all systems including the scrotum, kidney, and uterus. We report a 37-year-old male patient who presented to the urology clinic of a tertiary care hospital in Riyadh, Saudi Arabia, in 2021 with recurrent gradual scrotal swelling for four years attributed to scrotal AVM. Read More

Cureus 2023 Aug 29;15(8):e44349. Epub 2023 Aug 29.

Desai Sethi Urology Institute, University of Miami, Miami, USA.

Introduction And Objective: The long-term outcomes of varicocelectomy in adolescents is debated. The aim of this study was to evaluate symptom improvement, hypogonadism, and paternity in those who underwent adolescent sub-inguinal microscopic varicocelectomy.

Material And Methods: A retrospective chart review was done of adolescents (median=19, interquartile range (IQR)=16-19. Read More

Clin Chim Acta 2023 Aug 29;548:117530. Epub 2023 Aug 29.

College of Food Science and Light Industry, Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing 211816, People's Republic of China. Electronic address:

Background: Asthenozoospermia (AZS) is a disease characterized by decreased sperm motility induced by multiple etiologies, and the pathological mechanisms of various AZS are unclear. We simultaneously analyzed the metabolic profiling of four representative AZS to provide new insights into the etiologies of AZS.

Method: Seminal plasma samples were collected from healthy control (HC; n = 30) and four AZS induced by varicocele (VA, n = 30), obesity (OA, n = 22), reproductive system infections (RA; n = 17) and idiopathic (IA, n = 30), respectively, and were analyzed using gas chromatography-mass spectrometry. Read More

World J Mens Health 2023 Jul 27. Epub 2023 Jul 27.

Global Andrology Forum, Moreland Hills, OH, USA.

Purpose: There are no published examples of a global online research collaborative in andrology. We describe the development, profile and member characteristics of the first consortium of this type, the Global Andrology Forum (GAF).

Materials And Methods: An online survey sent to all GAF members collected demographic information (sex, age, experience, academic title, degrees, country, specialty, profession). Read More

Chin Med J (Engl) 2023 Aug 25. Epub 2023 Aug 25.

Reproductive Medical Department, Shanxi Provincial People's Hospital, Taiyuan, Shanxi 030012, China.

Urologia 2023 Aug 26:3915603231192739. Epub 2023 Aug 26.

Urology Department, Siirt Training and Research Hospital, Siirt, Turkey.

Background: Varicocele is the most common correctable cause of male infertility. The treatment of varicocele is surgery. However, which patients will benefit from the surgery is controversial. Read More

Appl Bionics Biomech 2023 16;2023:9854508. Epub 2023 Aug 16.

[This retracts the article DOI: 10.1155/2022/2629140.]. Read More

Evid Based Complement Alternat Med 2023 9;2023:9842923. Epub 2023 Aug 9.

[This retracts the article DOI: 10.1155/2022/7121245.]. Read More

Cell J 2023 Jul 25;25(7):437-446. Epub 2023 Jul 25.

Department of Animal Biotechnology, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran.

Testicular dysfunction, whether linked to varicocele, obesity, diabetes, aging, inflammation, or lifestyle or environmental issues, is frequently accompanied by an accumulation of unfolded or misfolded proteins, indicating impaired endoplasmic reticulum (ER) function. In this review, we examined the Google Scholar, Scopus and PubMed databases (from 2011 to 2022) to support the association of ER stress with defective spermatogenesis in animal models and humans. ER stress, whether in its pro-survival or pro-apoptotic aspect, appears to be closely linked to each studied situation. Read More

Medicine (Baltimore) 2023 Aug;102(31):e34476

Department of Pharmacy, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

Taohong Siwu Decoction (THSWD) was widely used for the treatment of varicocele-associated male infertility. However, the pharmacological mechanism of action is not completely clear. Therefore, network pharmacology and molecular docking were performed to explore potential mechanism of THSWD in the treatment of varicocele-associated male infertility. Read More

Prog Urol 2023 Sep 1;33(10):481-487. Epub 2023 Aug 1.

Service de chirurgie urologique, groupe hospitalier privé Ambroise-Paré, 48, ter boulevard Victor-Hugo, 92200 Neuilly-sur-Seine, France. Electronic address:

Introduction: The subinguinal microsurgical varicocelectomy is considered as the gold standard surgical technique for the treatment of varicocele. The objective of this study is to evaluate the results of this technique on the resolution of pain and the parameters of sperm analysis.

Methods: Single-center, retrospective study that includes 22 patients who have been operated over a period of six months for a clinically palpable varicocele via the microsurgical subinguinal technique. Read More

Arab J Urol 2023 9;21(3):190-197. Epub 2023 May 9.

Department of Surgery, Hamad Medical Corporation, Doha, Qatar.

Background: Few studies assessed the relationships between BMI and post varicocelectomy semen quality and fertility potential and they reported inconsistent findings.

Objective: To assess the association of BMI with semen parameters and reproductive hormones before and after microsurgical varicocelectomy.

Materials And Methods: Retrospective chart review in a tertiary infertility center. Read More

Int Braz J Urol 2023 ;49(5):637-643

Departamento de Urologia, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brasil.

Am J Reprod Immunol 2023 Aug;90(2):e13734

Department of Surgery, Division of Urology, Human Reproduction Section, São Paulo Federal University, São Paulo, Brazil.

During the last decades, a wide range of factors involved in the physiopathology of male infertility disease have been discussed. The inflammation role in some of the main infertility-related diseases has been studied, such as varicocele, spinal cord injury and obesity. Inflammation is the main response of the immune system to infection or cell damage, leading to intense inflammatory cytokine release during the loss of homeostasis. Read More

Heliyon 2023 Jun 9;9(6):e17161. Epub 2023 Jun 9.

Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objective: Zishen Yutai Pill (ZYP), containing 15 Chinese traditional medicine, is a safe and well quality-controlled TCM preparation with promising effects in many fields of reproduction. The current study was designed to investigate the therapeutic effects of ZYP on sperm quality and testis in varicocele (VC) rats.

Materials And Methods: Male Wistar rats were randomly divided into four groups (n = 6), i. Read More