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    9925 results match your criteria Varicella-Zoster Virus

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    The natural history of varicella zoster virus infection in Norway: Further insights on exogenous boosting and progressive immunity to herpes zoster.
    PLoS One 2017 18;12(5):e0176845. Epub 2017 May 18.
    Department of Economics and Management, University of Pisa, Pisa, Italy.
    We use age-structured models for VZV transmission and reactivation to reconstruct the natural history of VZV in Norway based on available pre-vaccination serological data, contact matrices, and herpes zoster incidence data. Depending on the hypotheses on contact and transmission patterns, the basic reproduction number of varicella in Norway ranges between 3.7 and 5. Read More

    Varicella zoster virus glycoprotein C increases chemokine-mediated leukocyte migration.
    PLoS Pathog 2017 May 25;13(5):e1006346. Epub 2017 May 25.
    Institute of Virology, Hannover Medical School, Hannover, Germany.
    Varicella zoster virus (VZV) is a highly prevalent human pathogen that establishes latency in neurons of the peripheral nervous system. Primary infection causes varicella whereas reactivation results in zoster, which is often followed by chronic pain in adults. Following infection of epithelial cells in the respiratory tract, VZV spreads within the host by hijacking leukocytes, including T cells, in the tonsils and other regional lymph nodes, and modifying their activity. Read More

    Herpes zoster - typical and atypical presentations.
    Postgrad Med 2017 May 25. Epub 2017 May 25.
    b Department of Family Medicine and Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences , Ben-Gurion University of the Negev , Beer-Sheva , Israel.
    Varicella- zoster virus infection is an intriguing medical entity that involves many medical specialties including infectious diseases, immunology, dermatology, and neurology. It can affect patients from early childhood to old age. Its treatment requires expertise in pain management and psychological support. Read More

    Bilateral acute retinal necrosis after bilateral cataract surgery in an immunocompromised patient: a case report.
    Int Ophthalmol 2017 May 23. Epub 2017 May 23.
    Department of Ophthalmology and Visual Sciences, The Prince of Wales Hospital, 1/F, Eye Centre, 30-32 NganShing Street, Shatin, New Territories, Hong Kong.
    Purpose: To report a case of bilateral varicella zoster virus (VZV)-associated acute retinal necrosis (ARN) occurring after both eyes sequential cataract surgery in an elderly immunocompromised patient.

    Methods: Medical records and investigation results of the patient were reviewed.

    Results: Patient experienced floaters and blurring of vision in both eyes 4 weeks after her second uncomplicated cataract surgery. Read More

    A case of acyclovir neurotoxicity presenting with atypical cerebrospinal fluid findings.
    BMJ Case Rep 2017 May 22;2017. Epub 2017 May 22.
    Internal Medicine, Western Michigan University School of Medicine, Kalamazoo, Michigan, USA.
    An 82-year-old man with a history of end-stage renal disease presented with progressively worsening confusion and somnolence for the past 4-5 days. The patient was diagnosed with herpes zoster by his primary care physician 5 days ago and was started on a course of valacyclovir 1 g three times a day (dose not adjusted for renal impairment).A lumbar puncture was performed and cerebrospinal fluid (CSF) studies revealed 37 white blood cells (WBCs)/hpf (100% monocytes), protein 64 mg/dL and glucose 52 mg/dL. Read More

    Varicella-zoster virus seroprevalence in children and adolescents in the pre-varicella vaccine era, Germany.
    BMC Infect Dis 2017 May 19;17(1):356. Epub 2017 May 19.
    Department of Epidemiology and Health Monitoring, Robert Koch Institute, Berlin, Germany.
    Background: In 2004, universal childhood varicella vaccination was introduced in Germany. We aimed to determine the age-specific prevalence of anti-varicella zoster virus (VZV) IgG-antibodies among children in the pre-varicella vaccine era in Germany, to identify factors associated with VZV seropositivity, and to assess the suitability of a commercially available ELISA for VZV seroepidemiological studies by comparing it with an in-house fluorescent antibody to membrane antigen test (FAMA) as the gold standard.

    Methods: Serum samples of 13,433 children and adolescents aged 1-17 years included in the population-based German Health Interview and Examination Survey for Children and Adolescents (KiGGS; conducted 2003-2006) were tested for anti-VZV IgG by ELISA. Read More

    The need for better preventative strategies for inflammatory bowel disease patients at risk of herpes zoster virus.
    Intern Med J 2017 May 17. Epub 2017 May 17.
    Department of Gastroenterology and Hepatology, St Vincent's Hospital Sydney, NSW, Australia.
    Background: Immunosuppressed IBD patients have an increased risk of HZV infection. The existing live-attenuated HZV vaccine is contraindicated in some of these patients and can only be used with caution in others.

    Aims: To describe characteristics of IBD patients suffering HZV to enable implementation of risk mitigation strategies for those at highest risk. Read More

    Sex differences underlying orofacial varicella zoster associated pain in rats.
    BMC Neurol 2017 May 17;17(1):95. Epub 2017 May 17.
    Department of Biomedical Sciences, Texas A&M University College of Dentistry, 3302 Gaston Avenue, Dallas, TX, 75246, USA.
    Background: Most people are initially infected with varicella zoster virus (VZV) at a young age and this infection results in chickenpox. VZV then becomes latent and reactivates later in life resulting in herpes zoster (HZ) or "shingles". Often VZV infects neurons of the trigeminal ganglia to cause ocular problems, orofacial disease and occasionally a chronic pain condition termed post-herpetic neuralgia (PHN). Read More

    Acute retinal necrosis: presenting characteristics and clinical outcomes in a cohort of polymerase chain reaction-positive patients.
    Am J Ophthalmol 2017 May 10. Epub 2017 May 10.
    Johns Hopkins University School of Medicine, The Wilmer Eye Institute, 733 North Broadway, Baltimore, Maryland; Johns Hopkins Bloomberg School of Public Health, Department of Epidemiology, 615 North Wolfe Street, Baltimore, Maryland.
    Purpose: To identify determinants of adverse outcomes in acute retinal necrosis (ARN), presenting characteristics and incidence rates of vision loss and ocular complications in a cohort of polymerase chain reaction (PCR)-positive eyes were analyzed.

    Design: Retrospective, observational cohort study.

    Methods: Forty-one eyes of 36 patients with clinically-diagnosed ARN, PCR-positive for herpes simplex virus or varicella zoster virus and evaluated between January 2002 and June 2013, were included. Read More

    Varicella Zoster Virus-Associated Necrotizing Retinitis after Chickenpox in a 10-Year-Old Female: A Case Report.
    Pediatr Infect Dis J 2017 May 11. Epub 2017 May 11.
    1Department of Ophthalmology, Hanyang University College of Medicine, Seoul, South Korea 2Division of Infectious Diseases, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, South Korea 3Division of Gastroenterology and Hepatology, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, South Korea.
    A necrotizing retinitis in children is a rare but vision threatening ocular complication of chickenpox. We report a 10-year-old girl who developed chickenpox one month before presenting with panuveitis and necrotizing retinitis. After prompt antiviral treatment, her inflammatory signs were resolved. Read More

    Ethnopharmacological uses, phytochemistry, biological activities, and therapeutic applications of Clinacanthus nutans (Burm. f.) Lindau: A comprehensive review.
    J Ethnopharmacol 2017 May 8. Epub 2017 May 8.
    Pharmacy, School of Medicine, University of Tasmania, 7001 Hobart, Tasmania, Australia.
    Ethnopharmacological Relevance: Clinacanthus nutans (Burm. f.) Lindau, a widely used medicinal plant, is extensively grown in tropical Asia and Southeast Asian countries. Read More

    Microbial Vertical Transmission during Human Pregnancy.
    Cell Host Microbe 2017 May;21(5):561-567
    Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA; Center for Microbial Pathogenesis, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA; Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA. Electronic address:
    Congenital infections with pathogens such as Zika virus, Toxoplasma gondii, Listeria monocytogenes, Treponema pallidium, parvovirus, HIV, varicella zoster virus, Rubella, Cytomegalovirus, and Herpesviruses are a major cause of morbidity and mortality worldwide. Despite the devastating impact of microbial infections on the developing fetus, relatively little is known about how pathogens associated with congenital disease breach the placental barrier to transit vertically during human pregnancy. In this Review, we focus on transplacental transmission of pathogens during human gestation. Read More

    Infections in Hematopoietic Cell Transplant Recipients: Results From the Organ Transplant Infection Project, a Multicenter, Prospective, Cohort Study.
    Open Forum Infect Dis 2017 22;4(2):ofx050. Epub 2017 Mar 22.
    University of Alabama at Birmingham.
    Background: Infection is a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Our object was to better define the epidemiology and outcomes of infections after HCT.

    Methods: This was a prospective, multicenter cohort study of HCT recipients and conducted from 2006 to 2011. Read More

    Varicella-zoster virus (VZV) multifocal vasculopathy in a patient with systemic lupus erythematosus - a diagnostic and treatment dilemma.
    IDCases 2017 25;8:81-83. Epub 2017 Apr 25.
    Division of Infectious Diseases, Department of Medicine, Mount Sinai Beth Israel, New York, NY, United States.
    Cerebral vasculopathy due to varicella-zoster virus (VZV) infection is well-documented. We report a fatal case of VZV multifocal vasculopathy in a patient with systemic lupus erythematosus (SLE) who presented with subacute changes in mental status and had multiple areas of hemorrhagic infarcts on brain imaging. However, the correct diagnosis was delayed by several confounding factors including the absence of zoster rash, normal cerebral angiography, persistently low cerebrospinal fluid (CSF) glucose and negative initial polymerase chain reaction (PCR) for VZV DNA in the CSF. Read More

    Herpes virus seroepidemiology in the adult Swedish population.
    Immun Ageing 2017 10;14:10. Epub 2017 May 10.
    Department of Clinical Microbiology, Virology, Umeå University, Umeå, Sweden.
    Background: Herpes viruses establish a life-long latency and can cause symptoms during both first-time infection and later reactivation. The aim of the present study was to describe the seroepidemiology of Herpes simplex type 1 (HSV1), Herpes simplex type 2 (HSV2), Cytomegalovirus (CMV), Varicella Zoster virus (VZV) and Human herpes virus type 6 (HHV6) in an adult Swedish population (35-95 years of age).

    Methods: Presence of antibodies against the respective viruses in serum from individuals in the Betula study was determined with an enzyme-linked immunosorbent assay (ELISA). Read More

    Vaccine profile of herpes zoster (HZ/su) subunit vaccine.
    Expert Rev Vaccines 2017 May 19:1-10. Epub 2017 May 19.
    b Genocea Biosciences, Inc ., Cambridge , MA , USA.
    Introduction: Herpes zoster (HZ) causes an often severe and painful rash in older people and may be complicated by prolonged pain (postherpetic neuralgia; PHN) and by dissemination in immune-compromised patients. HZ results from reactivation of latent varicella-zoster virus (VZV) infection, often associated with age-related or other causes of decreased T cell immunity. A live attenuated vaccine boosts this immunity and provides partial protection against HZ, but this decreases with age and declines over 8 years. Read More

    A Trivalent Subunit Antigen Glycoprotein Vaccine as Immunotherapy for Genital Herpes in the Guinea Pig Genital Infection Model.
    Hum Vaccin Immunother 2017 May 8. Epub 2017 May 8.
    a Infectious Disease Division, Department of Medicine , Perelman School of Medicine, University of Pennsylvania , Philadelphia , Pennsylvania , United States of America.
    An estimated 417 million people worldwide ages 15 to 49 are infected with herpes simplex virus type 2 (HSV-2), the most common cause of genital ulcer disease. Some individuals experience frequent recurrences of genital lesions, while others only have subclinical infection, yet all risk transmitting infection to their intimate partners. A vaccine was developed that prevents shingles, which is a recurrent infection caused by varicella-zoster virus (VZV), a closely related member of the Herpesviridae family. Read More

    Herpes zoster vaccine: A health economic evaluation for Switzerland.
    Hum Vaccin Immunother 2017 May 8:1-10. Epub 2017 May 8.
    a University of Basel, Institute of Pharmaceutical Medicine (ECPM) , Basel , Switzerland.
    Herpes zoster (HZ) or "shingles" results from a reactivation of the varicella zoster virus (VZV) acquired during primary infection (chickenpox) and surviving in the dorsal root ganglia. In about 20% of cases, a complication occurs, known as post-herpetic neuralgia (PHN). A live attenuated vaccine against VZV is available for the prevention of HZ and subsequent PHN. Read More

    Herpes Zoster and Recurrent Herpes Zoster.
    Open Forum Infect Dis 2017 28;4(1):ofx007. Epub 2017 Jan 28.
    Department of Virology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan.
    Background: The incidence of recurrent herpes zoster (HZ) and the relationship between initial and recurrent HZ are not clear.

    Methods: The Miyazaki Dermatologist Society has surveyed ~5000 patients with HZ annually since 1997. A questionnaire regarding HZ and its recurrence was completed by the dermatologists. Read More

    New insights into the pathogenesis of giant cell arteritis.
    Autoimmun Rev 2017 May 4. Epub 2017 May 4.
    Dipartimento Biomedico di Medicina Interna e Specialistica, Sezione di Reumatologia, Università degli Studi di Palermo, Palermo, Italy. Electronic address:
    Giant cell arteritis (GCA) is an inflammatory chronic disease occurring exclusively in elderly individuals. Until recently, the disease has been considered a unique disease resulting from the interaction in the walls of susceptible arteries, between an unknown infectious agents with local dendritic cells (DCs), activated CD4 T cells and effector macrophages. Recent evidence has shown that this view was too simplistic and has clarified many of the pathogenetic aspects of the disease. Read More

    Molecular diagnosis of central nervous system opportunistic infections and mortality in HIV-infected adults in Central China.
    AIDS Res Ther 2017 2;14:24. Epub 2017 May 2.
    Basic Medical College of Wuhan University, Wuhan, China.
    Background: CSF PCR is the standard diagnostic technique used in resource-rich settings to detect pathogens of the CNS infection. However, it is not currently used for routine CSF testing in China. Knowledge of CNS opportunistic infections among people living with HIV in China is limited. Read More

    Functionality testing of stem cell grafts to predict infectious complications after allogeneic hematopoietic stem cell transplantation.
    Vox Sang 2017 May 2. Epub 2017 May 2.
    Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
    Background And Objectives: Allogeneic hematopoietic stem cell transplantation (HSCT) is a routine clinical procedure performed to treat patients with haematological malignancies, primary immune deficiencies or metabolic disorders. Infections during lymphopenia after allogeneic HSCT are associated with high mortality and morbidity. Typical infectious agents are Epstein-Barr virus, cytomegalovirus, herpes simplex virus, varicella-zoster virus and fungi. Read More

    An unusual presentation of varicella zoster virus with acute cerebellitis and SIADH without a rash.
    J Clin Neurosci 2017 Apr 28. Epub 2017 Apr 28.
    Department of Neurology, St Vincent's Hospital, 390 Victoria St, Darlinghurst, NSW, 2010 Sydney, Australia; University of New South Wales, School of Medicine, Sydney, NSW 2052, Australia. Electronic address:
    We report a case of varicella-zoster virus (VZV) infection with acute cerebellitis and encephalitis with associated Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) in an elderly man presenting with acute cerebellar ataxia without antecedent rash. Cerebrospinal fluid examination (CSF) revealed a mononuclear pleocytosis, high protein, normal glucose, positive for VZV polymerase chain reaction (PCR). Early acyclovir treatment is beneficial for acute VZV cerebellitis. Read More

    [Epidemiology and natural history of giant cell arteritis].
    Rev Med Interne 2017 Apr 27. Epub 2017 Apr 27.
    Unité de médecine interne-maladies systémiques, unité de médecine interne-maladies systémiques, CHU Saint-Louis, université Paris-Diderot, 1, avenue Claude-Vellefaux, 75475 Paris cedex 10, France.
    Knowledge of the natural history and epidemiology of giant cell arteritis (GCA) is growing. With the recent conceptual change, GCA is no longer considered a disease with mandatory cranial symptoms but, rather, a larger disease spectrum also including idiopathic aortitis in people older than 50 and polymyalgia rheumatica with large-vessel involvement. The incidence peak between age 70 and 80 years, greater frequency in females and greater occurrence in Nordic countries are well-established epidemiological characteristics. Read More

    Phosphonoamidate prodrugs of C5-substituted pyrimidine acyclic nucleosides for antiviral therapy.
    Antiviral Res 2017 Jul 25;143:262-268. Epub 2017 Apr 25.
    Rega Institute for Medical Research, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.
    Acyclic nucleoside phosphonates (ANPs) are nowadays one of the key drugs in the treatment of DNA virus and retrovirus infections. In this work, we report the synthesis and antiviral evaluation of phosphonoamidate and diamidates prodrugs of C5-pyrimidine acyclic nucleosides derivatives functionalized with but-2-enyl- chain. In the phosphonoamidate series, the most active compound 15, showed sub-micromolar activity against varicella zoster virus (VZV) (EC50 = 0. Read More

    Epidemiological surveillance of herpes viral encephalitis in Cordoba, Colombia.
    Rev Salud Publica (Bogota) 2016 Aug;18(4):581-591
    University of São Paulo, Brazil.
    Objective To establish an epidemiological surveillance of viral herpes encephalitis in major hospitals of Monteria, Cordoba. Methods From September 2009 to December 2011, a descriptive study of cases of viral encephalitis was made in three hospitals in the city of Monteria. Cerebrospinal fluid (CSF) samples from 118 patients were included in the study. Read More

    Receipt of thyroid hormone deficiency treatment and risk of herpes zoster.
    Int J Infect Dis 2017 Apr 24;59:90-95. Epub 2017 Apr 24.
    Department of Research and Evaluation, Kaiser Permanente Research, 100 S. Los Robles Ave, 2nd Floor, Pasadena, CA 91101, USA. Electronic address:
    Objective: Thyroid hormone (TH) has been suggested to control herpes virus gene expression and replication in neurons via epigenetics through its nuclear receptors. It has previously been shown that patients with hypothyroidism are predisposed to herpes zoster (HZ), suggesting that the TH deficiency may be a risk factor for varicella zoster virus (VZV) reactivation. The aim of this study was to test the hypothesis that TH treatment will ameliorate the complication of HZ. Read More

    Disarming Cellular Alarm Systems-Manipulation of Stress-Induced NKG2D Ligands by Human Herpesviruses.
    Front Immunol 2017 11;8:390. Epub 2017 Apr 11.
    Faculty of Medicine, The Lautenberg Center for General and Tumor Immunology, The BioMedical Research Institute Israel-Canada, The Hebrew University Hadassah Medical School, Jerusalem, Israel.
    The coevolution of viruses and their hosts led to the repeated emergence of cellular alert signals and viral strategies to counteract them. The herpesvirus family of viruses displays the most sophisticated repertoire of immune escape mechanisms enabling infected cells to evade immune recognition and thereby maintain infection. The herpesvirus family consists of nine viruses that are capable of infecting humans: herpes simplex virus 1 and 2 (HSV-1, HSV-2), varicella zoster virus (VZV), Epstein-Barr virus (EBV), human cytomegalovirus (HCMV), roseoloviruses (HHV-6A, HHV-6B, and HHV-7), and Kaposi's-sarcoma-associated herpesvirus (KSHV). Read More

    Ramsay Hunt syndrome in a patient with human immunodeficiency virus infection.
    Indian J Sex Transm Dis 2017 Jan-Jun;38(1):89-91
    Treatwell Skin Centre, Canal Road, Jammu, Jammu and Kashmir, India.
    Ramsay Hunt syndrome (RHS) is a rare, severe complication of varicella-zoster virus reactivation in the geniculate ganglion, characterized by hearing loss, pain, and vesicles in the ear or mouth along with ipsilateral facial palsy. Although it is rare, it is more commonly found with immunodeficiency conditions. We report a case of a 35-year-old human immunodeficiency virus positive male, having CD4+ count of 336/μl, who presented with RHS and had vertigo, painful vesicular eruptions on the right ear and unilateral sensorineural hearing loss. Read More

    Multidisciplinary study of the secondary immune response in grandparents re-exposed to chickenpox.
    Sci Rep 2017 Apr 24;7(1):1077. Epub 2017 Apr 24.
    Centre for Health Economics Research & Modeling Infectious Diseases (CHERMID), Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Antwerp, Belgium.
    Re-exposure to chickenpox may boost varicella-zoster virus (VZV) immunity in the elderly. This secondary immune response is hypothesized to confer protection against herpes zoster. We longitudinally sampled 36 adults over the course of one year after re-exposure to chickenpox. Read More

    Viral aetiologies of acute encephalitis in a hospital-based South Asian population.
    BMC Infect Dis 2017 Apr 24;17(1):303. Epub 2017 Apr 24.
    Department of Clinical Medicine, Faculty of Medicine - University of Colombo, 25, Kynsey Road, Colombo, 00800, Sri Lanka.
    Background: The aetiological spectrum of acute encephalitis shows inter- and intra-geographical variations. We aimed to identify the viruses that cause infectious encephalitis in Sri Lanka, which represents a South Asian population.

    Methods: A cross-sectional study was conducted among 99 patients with encephalitis/meningoencephalitis admitted to two tertiary-care hospitals in Colombo. Read More

    Advances in pharmacotherapeutic management of common skin diseases in neonates and infants.
    Expert Opin Pharmacother 2017 May 21;18(7):717-725. Epub 2017 Apr 21.
    a Dermatology, Department of Experimental, Diagnostic and Specialty Medicine , Sant'Orsola-Malpighi Hospital, University of Bologna , Bologna , Italy.
    Introduction: neonatal and infantile skin diseases are frequently encountered in the clinical practice and represent worldwide a socioeconomic issue. They encompass a wide range of acquired or congenital conditions, including infections, vascular lesions and inflammatory diseases and can present with different degrees of severity, leading in some cases to dramatic complications. Areas covered: In this paper we report the most recent evidences on the management of some common skin diseases in neonates and infants. Read More

    A critical appraisal of 'Shingrix', a novel Herpes Zoster Subunit (HZ/Su or GSK1437173A) vaccine for Varicella Zoster Virus.
    Hum Vaccin Immunother 2017 Apr 20. Epub 2017 Apr 20.
    c University College London , London , United Kingdom.
    HZ/Su, branded as 'Shingrix', is one of the newest vaccines to be submitted for multi-national regulatory approval. It is targeted to prevent shingles, predominantly affecting the elderly, but a global concern with ageing populations and significant associated morbidity and mortality. A vaccine for shingles has been available for over a decade, however it is contraindicated in specific subgroups of people, and there are added concerns regarding long-term immunogenicity. Read More

    Varicella vaccination elicits a humoral and cellular response in children with rheumatic diseases using immune suppressive treatment.
    Vaccine 2017 May 12;35(21):2818-2822. Epub 2017 Apr 12.
    Laboratory for Translational Immunology, Paediatric Immunology, University Medical Center Utrecht, Utrecht, The Netherlands; Department of Paediatric Rheumatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands.
    Objective: To assess humoral and cellular responses to live-attenuated varicella zoster virus (VZV) vaccination of patients with juvenile idiopathic arthritis (JIA), juvenile dermatomyositis (JDM) or juvenile scleroderma (JScle) compared to those of healthy controls (HC).

    Methods: Before, 4-6weeks and one year after VZV vaccination, blood samples of patients and HC were collected. VZV-specific antibody concentrations were measured by ELISA and multiplex immune-assay. Read More

    Reactivation of Herpes Zoster Keratitis With Corneal Perforation After Zoster Vaccination.
    Cornea 2017 Jun;36(6):740-742
    Departments of *Ophthalmology; and †Pathology, University of Ottawa, The Ottawa Hospital, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
    Purpose: We present a case of reactivated herpes zoster keratouveitis of 6 years duration with corneal perforation requiring penetrating keratoplasty shortly after inoculation with herpes zoster vaccine (Zostavax, Merck, Quebec, Canada).

    Methods: Retrospective case report.

    Results: A 67-year-old woman with a 5-year history of recurrent unilateral herpes zoster keratouveitis in her right eye presented with another recurrence 2 weeks after Zostavax vaccination. Read More

    A novel combined vaccine based on monochimeric VLP co-displaying multiple conserved epitopes against enterovirus 71 and varicella-zoster virus.
    Vaccine 2017 May 10;35(20):2728-2735. Epub 2017 Apr 10.
    State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, Xiamen, China.
    Chicken pox and hand, foot and mouth disease (HFMD) are two major infectious diseases that mainly affect infants and children, causing significant morbidity annually. Varicella-zoster virus (VZV) and enterovirus 71 (EV71), respectively, are the principal epidemic pathogens causing these two diseases. To investigate the possibility of developing a novel combined vaccine to prevent chicken pox and HFMD, we constructed three chimeric virus-like particles (VLPs) (termed HBc-V/1/2, HBc-2/V/1 and HBc-1/2/V) based on the hepatitis B core antigen (HBc) carrier that display epitopes derived from VZV-gE, EV71-VP1, and EV71-VP2 in a varied tandem manner. Read More

    [Varicella gastritis under immunosuppression : Case report of a woman after lung transplantation due to granulomatosis with polyangiitis].
    Internist (Berl) 2017 Apr 12. Epub 2017 Apr 12.
    Abteilung Innere Medizin II (Onkologie, Hämatologie, Rheumatologie, Immunologie, Pulmonologie), Universitätsklinikum Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Deutschland.
    A 35-year-old woman who had previously undergone a lung transplantation presented with severe abdominal pain and vomiting. The gastroscopy showed diffuse ulcerative gastric lesions. Tests for varicella zoster virus and Epstein-Barr virus via polymerase chain reactions (PCR) on endoscopically obtained gastric biopsies were found to be positive and confirmed varicella gastritis. Read More

    Evaluation of TaqMan Array Card (TAC) for the Detection of Central Nervous System Infections in Kenya.
    J Clin Microbiol 2017 Apr 12. Epub 2017 Apr 12.
    Division of Global Health Protection, CDC-Kenya.
    Infections of the central nervous system (CNS) are often acute with significant morbidity and mortality. Routine diagnosis of such infections is limited in developing countries and requires modern equipment in advanced laboratories that may be unavailable to a number of patients in sub-Saharan Africa. We developed a TaqMan Array Card (TAC) that detects multiple pathogens simultaneously from cerebrospinal fluid (CSF). Read More

    Inhibitors of dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) exert a strong anti-herpesviral activity.
    Antiviral Res 2017 Jul 9;143:113-121. Epub 2017 Apr 9.
    Institute for Clinical and Molecular Virology, Friedrich-Alexander University of Erlangen-Nürnberg (FAU), Germany. Electronic address:
    Infection with human cytomegalovirus (HCMV) is a serious medical problem, particularly in immunocompromised individuals and neonates. The success of (val)ganciclovir therapy is hampered by low drug compatibility and induction of viral resistance. A novel strategy of antiviral treatment is based on the exploitation of cell-directed signaling, e. Read More

    Real-time PCR Detection of the Most Common Bacteria and Viruses Causing Meningitis.
    Clin Lab 2017 Apr;63(4):827-832
    Background: Central nervous system (CNS) infections require prompt diagnosis, as the clinical condition progresses rapidly and may lead to severe permanent sequelae or death. The causative agents include viruses, bacteria, fungi, and parasites. In this study, samples with the diagnosis of CNS infection based on cerebrospinal fluid (CSF) sent to us from other hospitals/labs, were studied by multiplex real-time Polymerase Chain Reaction (PCR) method. Read More

    The burden and epidemiology of community-acquired central nervous system infections: a multinational study.
    Eur J Clin Microbiol Infect Dis 2017 Apr 10. Epub 2017 Apr 10.
    Infection Control Department, Saudi German Hospital Group, Jeddah, Saudi Arabia.
    Risk assessment of central nervous system (CNS) infection patients is of key importance in predicting likely pathogens. However, data are lacking on the epidemiology globally. We performed a multicenter study to understand the burden of community-acquired CNS (CA-CNS) infections between 2012 and 2014. Read More

    Acute Facial Nerve Palsy With Ipsilateral Soft Palate Ulcers.
    J Oral Maxillofac Surg 2017 Mar 14. Epub 2017 Mar 14.
    Associate Professor, AP-HP, Service de chirurgie maxillo-faciale, Hôpital Universitaire Pitié-Salpêtrière, Paris; Université Pierre-et-Marie-Curie, Paris, France. Electronic address:
    Ramsay-Hunt syndrome (RHS) is a rare complication of herpes zoster in which reactivation of latent varicella zoster virus (VZV) infection occurs in the geniculate ganglion. Major clinical findings are peripheral facial nerve palsy accompanied by ipsilateral ear pain and erythematous vesicular rash on the external ear (herpes zoster oticus) and in the mouth. Thus, diagnosis of RHS is usually clinical. Read More

    Varicella zoster virus infection after allogeneic hematopoietic cell transplantation in children using a relatively short duration of acyclovir prophylaxis: A retrospective study.
    Medicine (Baltimore) 2017 Apr;96(14):e6546
    aDepartment of Pediatrics bThe Vaccine Bio Research Institute cThe Catholic Blood and Marrow Transplantation Center dDivision of Infectious Diseases, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
    Although acyclovir prophylaxis against varicella zoster virus (VZV) infection for ≥1 year is recommended after allogeneic hematopoietic cell transplantation (HCT), the emergence of acyclovir-resistant viruses and adverse drug effects cannot be ignored. We investigated the cumulative incidence of VZV infection after allogeneic HCT in children receiving a shorter duration of acyclovir prophylaxis than recommended and evaluated the appropriateness of the short duration of acyclovir prophylaxis.Medical records of 217 children who received allogeneic HCT were retrospectively reviewed until a median of 25 months (range = 1-59 months) after HCT. Read More

    Varicella-Zoster Virus Gastritis.
    Int J Surg Pathol 2017 Mar 1:1066896917696751. Epub 2017 Mar 1.
    1 University of Calgary, Calgary, Alberta, Canada.
    We report varicella-zoster virus (VZV) gastritis in a 70-year-old woman postchemotherapy for lymphoma, presenting with abdominal pain, vomiting, and delirium without rash. A gastric biopsy demonstrated viral inclusions but posed a diagnostic challenge as immunohistochemistry for cytomegalovirus and herpes simplex virus were negative, and VZV immunohistochemistry was not available. The patient developed a vesicular rash 7 days after her symptoms began. Read More

    Quantitative, phenotypical and functional characterization of cellular immunity in pediatric individuals with Down syndrome.
    J Infect Dis 2017 Apr 4. Epub 2017 Apr 4.
    Department of Transplant and Infection Immunology, Saarland University, Homburg, Germany.
    Background: Infections and autoimmune disorders are more frequent in Down syndrome, suggesting abnormality of adaptive immunity. While the role of B-cells and antibodies is well characterized, knowledge regarding T-cells is limited.

    Methods: Lymphocyte subpopulations of 40 children and adolescents with Down syndrome and 51 controls were quantified, and phenotype and functionality of antigen-specific effector T-cells were flow-cytometrically analyzed after polyclonal and pathogen-specific stimulation (varicella-zoster virus (VZV), cytomegalovirus (CMV)). Read More

    TLR3 mutations in adult patients with Herpes Simplex virus and Varicella Zoster virus encephalitis.
    J Infect Dis 2017 Mar 27. Epub 2017 Mar 27.
    Division of Infectious Diseases, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy.
    Defects in genes of the TLR3 pathway are associated with susceptibility to HSV-1 encephalitis (HSE). We analyzed a cohort of 11 adult Italian patients who developed viral encephalitis. We detected two rare missense mutations in TLR3: one in a HSE patient (p. Read More

    Varicella-Zoster Virus Glycoproteins: Entry, Replication, and Pathogenesis.
    Curr Clin Microbiol Rep 2016 Dec 9;3(4):204-215. Epub 2016 Sep 9.
    Departments of Pediatrics and Microbiology & Immunology, Stanford University School of Medicine, Stanford, California, 94305-5208.
    Varicella-zoster virus (VZV), an alphaherpesvirus that causes chicken pox (varicella) and shingles (herpes zoster), is a medically important pathogen that causes considerable morbidity and, on occasion, mortality in immunocompromised patients. Herpes zoster can afflict the elderly with a debilitating condition, postherpetic neuralgia, triggering severe, untreatable pain for months or years. The lipid envelope of VZV, similar to all herpesviruses, contains numerous glycoproteins required for replication and pathogenesis. Read More

    Intramuscularly administered herpes zoster subunit vaccine has no effects on fertility, pre- and post-natal development in Sprague-Dawley rats.
    Reprod Toxicol 2017 Apr 31;69:297-307. Epub 2017 Mar 31.
    GSK Vaccines, Rixensart, Belgium. Electronic address:
    The herpes zoster subunit vaccine (HZ/su) is an investigational vaccine for the prevention of shingles, a disease caused by the varicella zoster virus (VZV). It is composed of recombinant VZV glycoprotein E (gE) and AS01. We assessed the potential toxic effects of gE/AS01 and AS01 alone on female and male fertility, and on embryo-fetal, pre- and post-natal development in Sprague-Dawley rats. Read More

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