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    10233 results match your criteria Varicella-Zoster Virus

    1 OF 205

    Shingrix: The New Adjuvanted Recombinant Herpes Zoster Vaccine.
    Ann Pharmacother 2018 Feb 1:1060028018758431. Epub 2018 Feb 1.
    3 Saint Joseph Hospital, Denver, CO, USA.
    Objectives: To review the immunogenicity, efficacy, and safety of the herpes zoster subunit vaccine (HZ/su) for use in adult patients for the prevention of shingles.

    Data Sources: A literature search through PubMed was conducted (June 2008 to October 2017) using the terms shingles vaccine and varicella zoster virus. References from retrieved articles and the prescribing information were also reviewed for any additional material. Read More

    Helicase-primase inhibitor amenamevir for herpesvirus infection: Towards practical application for treating herpes zoster.
    Drugs Today (Barc) 2017 Nov;53(11):573-584
    Department of Virology, University of Toyama, Toyoma, Japan.
    Valacyclovir and famciclovir enabled successful systemic therapy for treating herpes simplex virus (HSV) and varicella zoster virus (VZV) infection by their phosphorylation with viral thymidine kinase. Helicase-primase inhibitors (HPIs) inhibit the progression of the replication fork, an initial step in DNA synthesis to separate the double strand into two single strands. The HPIs amenamevir and pritelivir have a novel mechanism of action, once-daily administration with nonrenal excretory characteristics, and clinical efficacy for genital herpes. Read More

    ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an Infectious Diseases perspective (Agents targeting lymphoid cells surface antigens [I]: CD19, CD20 and CD52).
    Clin Microbiol Infect 2018 Feb 12. Epub 2018 Feb 12.
    Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany.
    Background: The present review is part of the ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies.

    Aims: To review, from an Infectious Diseases perspective, the safety profile of agents targeting CD19, CD20 and CD52 and to suggest preventive recommendations.

    Sources: Computer-based MEDLINE searches with MeSH terms pertaining to each agent or therapeutic family. Read More

    Cytoskeletons in the Closet-Subversion in Alphaherpesvirus Infections.
    Viruses 2018 Feb 13;10(2). Epub 2018 Feb 13.
    Centre for Virus Research, The Westmead Institute for Medical Research, The University of Sydney, Westmead, NSW 2145, Australia.
    Actin filaments, microtubules and intermediate filaments form the cytoskeleton of vertebrate cells. Involved in maintaining cell integrity and structure, facilitating cargo and vesicle transport, remodelling surface structures and motility, the cytoskeleton is necessary for the successful life of a cell. Because of the broad range of functions these filaments are involved in, they are common targets for viral pathogens, including the alphaherpesviruses. Read More

    Chickenpox outbreak in a tribal and industrial zone from the Union Territory of Dadra and Nagar Haveli, India.
    Epidemiol Infect 2018 Feb 13:1-5. Epub 2018 Feb 13.
    ICMR-National Institute of Virology,20-A Dr Ambedkar Road,Pune 411001,India.
    During 9th December 2016 and 12th February 2017, 149-chickenpox cases were reported in a tribal and industrial zone of Rakholi (n = 80) and Surangi (n = 69) villages from Union Territory of India. An epidemiological investigation was performed to assess the characteristics and determinants of the chickenpox outbreak. Overall, the attack rate per 100 population in Rakholi village (n = 1757) was 4. Read More

    [Trigeminal Herpes Zoster Presenting with High-intensity Signals for the Spinal Trigeminal Nucleus and Tract on Diffusion-weighted Image: A Case Report of Stroke Mimic].
    Brain Nerve 2018 Feb;70(2):161-164
    Department of Neurology, Brain Attack Center, Ota Memorial Hospital.
    A 50-year-old woman was admitted to our hospital with dysesthesia on the right upper portion of her face and a headache. Diffusion-weighted brain magnetic resonance imaging (MRI) revealed high-intensity signals in the dorsolateral portion of the medulla oblongata. She was diagnosed with lateral medullary infarction and was intravenously treated with sodium ozagrel. Read More

    Community-Acquired Meningitis in HIV-Infected Patients in the United States.
    AIDS Patient Care STDS 2018 Feb;32(2):42-47
    Division of Infectious Diseases, Department of Internal Medicine, McGovern Medical School at The University of Texas Health Science Center , Houston, Texas.
    We conducted a retrospective study of 549 adults admitted with community-acquired meningitis (CAM) to several hospitals in New Orleans, LA and Houston, TX between 1999 and 2014 to characterize the current epidemiology, clinical manifestations, cerebrospinal fluid (CSF) characteristics, and outcomes of CAM between HIV-infected and uninfected patients and to identify risk factors for adverse outcomes in CAM. Bivariate analysis and logistic regression analysis were used to identify prognostic factors. A total of 1022 patients with CAM were screened. Read More

    Herpes Zoster and Postherpetic Neuralgia: Prevention and Management.
    Am Fam Physician 2017 Nov;96(10):656-663
    Nellis Family Medicine Residency, Mike O'Callaghan Federal Medical Center, Nellis Air Force Base, NV, USA.
    Herpes zoster, or shingles, is caused by reactivation of varicella zoster virus, which causes chickenpox. There are an estimated 1 million cases in the Unites States annually, with an individual lifetime risk of 30%. Patients with conditions that decrease cell-mediated immunity are 20 to 100 times more likely to develop herpes zoster. Read More

    Incidence and costs of herpes zoster and postherpetic neuralgia in German adults aged ≥50 years: A prospective study.
    J Infect 2018 Feb 8. Epub 2018 Feb 8.
    GSK, Avenue Fleming 20, 1300 Wavre, Belgium. Electronic address:
    Objectives: Herpes zoster (HZ) mainly affects elderly people and immunocompromised individuals. HZ is usually characterized by a unilateral painful skin rash. Its most common complication, postherpetic neuralgia (PHN), may cause chronic debilitating pain. Read More

    ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an Infectious Diseases perspective (Immune checkpoint inhibitors, cell adhesion inhibitors, sphingosine-1-phosphate receptor modulators and proteasome inhibitors).
    Clin Microbiol Infect 2018 Feb 7. Epub 2018 Feb 7.
    Department of Infectious Diseases, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
    Background: The present review is part of the ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies.

    Aims: To review, from an Infectious Diseases perspective, the safety profile of immune checkpoint inhibitors, LFA-3-targeted agents, cell adhesion inhibitors, sphingosine-1-phosphate receptor modulators and proteasome inhibitors and to suggest preventive recommendations.

    Sources: Computer-based MEDLINE searches with MeSH terms pertaining to each agent or therapeutic family. Read More

    Childhood peripheral facial palsy.
    Childs Nerv Syst 2018 Feb 9. Epub 2018 Feb 9.
    Department of Pediatric Neurology, Ankara Children's Hematology-Oncology Training and Research Hospital, Ankara, Turkey.
    Objective: The objectives of this study were to evaluate the demographic and clinical characteristics, causes, treatment patterns, outcome, and recurrence of childhood peripheral facial palsy.

    Methods: We performed a retrospective study of 144 peripheral facial palsy patients, under 18 years old in a tertiary care pediatric hospital. Medical charts were reviewed to analyze the age, gender, side of facial nerve paralysis, family history, cause, grading by the House-Brackmann Facial Nerve Grading Scale (HBS), results of diagnostic tests, therapies, outcomes, and recurrence. Read More

    Multi-viral canaliculitis: case report and review of literature.
    Int Ophthalmol 2018 Feb 9. Epub 2018 Feb 9.
    Jhaveri Microbiology Laboratory, L. V. Prasad Eye Institute, Hyderabad, 34, India.
    Aim: To report an atypical case of multiple viruses causing canaliculitis.

    Methods: Case report of a young female presenting with atypical course of refractory unilateral canaliculitis with complete mid-bicanalicular obstructions. Canalicular scrapings were subjected to immunofluorescence techniques and polymerase chain reactions to identify the viruses. Read More

    Localized Trichiasis Causing Focal Full-Thickness Corneal Edema, Endothelial Cell Loss, and Corneal Scarring Requiring Penetrating Keratoplasty.
    Middle East Afr J Ophthalmol 2017 Oct-Dec;24(4):216-218
    Department of Ophthalmology and Visual Science, Yale School of Medicine, New Haven, CT, USA.
    The purpose of the study was to report a case of focal trichiasis causing full-thickness corneal edema, scarring, and endothelial cell loss requiring penetrating keratoplasty (PK). A 66-year-old male was referred for trichiasis of the right upper eyelid corresponding to an area of full-thickness corneal edema. No keratic precipitates or guttata was noted. Read More

    Safety, and Humoral and Cell-mediated Immune Responses to Herpes Zoster Vaccine in Patients with Rheumatoid Arthritis.
    J Rheumatol 2018 Feb 1. Epub 2018 Feb 1.
    From the Division of Rheumatology, Department of Internal Medicine, St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea. J.H. Koh, MD, Division of Rheumatology, Department of Internal Medicine, St. Mary's Hospital, College of Medicine, The Catholic University of Korea; S.H. Kim, MD, Division of Rheumatology, Department of Internal Medicine, St. Mary's Hospital, College of Medicine, The Catholic University of Korea; S.K. Kwok, MD, PhD; Division of Rheumatology, Department of Internal Medicine, St. Mary's Hospital, and Rheumatism Research Center, College of Medicine, The Catholic University of Korea; J.H. Ju, MD, PhD, Division of Rheumatology, Department of Internal Medicine, St. Mary's Hospital, College of Medicine, The Catholic University of Korea; S.H. Park, MD, PhD, Division of Rheumatology, Department of Internal Medicine, St. Mary's Hospital, and Rheumatism Research Center, College of Medicine, The Catholic University of Korea; J. Lee, MS, Rheumatism Research Center, College of Medicine, The Catholic University of Korea. Address correspondence to Prof. S.H. Park, 222 Banpo-daero, Seocho-gu, Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea 06545. E-mail: Accepted for publication November 8, 2017.
    Objective: To examine humoral and cellular immune responses induced by a live attenuated herpes zoster (HZ) vaccine in patients with rheumatoid arthritis (RA) compared with osteoarthritis (OA) patients.

    Methods: This was an observational study of a live attenuated HZ vaccine in 41 patients with RA receiving conventional disease-modifying antirheumatic drugs (cDMARD) and/or low-dose glucocorticoids (GC) and in 28 patients with OA. Blood samples were obtained before and at 12 weeks after HZ vaccination. Read More

    Guillain-Barré syndrome following varicella-zoster virus infection.
    Eur J Clin Microbiol Infect Dis 2018 Mar 6;37(3):511-518. Epub 2018 Feb 6.
    Departments of Neurology and Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
    We describe the frequency, clinical features, and electrophysiological and immunological phenotypes of Guillain-Barré Syndrome (GBS) patients treated at a single institution in Bangladesh who had preceding chicken pox (primary Varicella-zoster virus [VZV] infection) within 4 weeks of GBS onset. A literature review of GBS cases preceding VZV infection is also provided. Diagnosis of GBS was based on the National Institute of Neurological Disorders and Stroke criteria for GBS. Read More

    Age-Dependent Pre-Vaccination Immunity Affects the Immunogenicity of Varicella Zoster Vaccination in Middle-aged Adults.
    Front Immunol 2018 23;9:46. Epub 2018 Jan 23.
    Centre for Infectious Disease Control (Cib), National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.
    Background: Prevention of infectious diseases is of high priority in the rapidly aging population. Unfortunately, vaccine responses in the elderly are frequently diminished. Timely vaccination of middle-aged adults might improve the immune responses to vaccines, although knowledge on pathogen-specific immune responses and factors affecting these responses, in middle-aged adults is currently limited. Read More

    Infectious meningitis and encephalitis in adults in Denmark: A prospective nationwide observational cohort study (DASGIB).
    Clin Microbiol Infect 2018 Jan 30. Epub 2018 Jan 30.
    Department of Infectious Diseases, Aalborg University Hospital, Mølleparkvej 4, 9000 Aalborg, Denmark.
    Objectives: To monitor epidemiological trends of infectious meningitis (bacterial and viral) and encephalitis in Denmark.

    Methods: Nation-wide prospective observational study of all cases with proven community-acquired infectious meningitis and encephalitis in adults treated in all departments of infectious diseases in Denmark from 1of January 2015 to 30of June 2016. We included data on symptoms, aetiology, treatment and outcome assessed by the Glasgow Outcome Scale (GOS) 30-days after discharge. Read More

    Varicella-Zoster Virus DNA in Blood After Administration of Herpes Zoster Vaccine.
    J Infect Dis 2018 Feb 2. Epub 2018 Feb 2.
    Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora.
    We studied the relationship between varicella-zoster virus (VZV) DNAemia and development of VZV-specific immunity after administration of live-attenuated zoster vaccine. VZV-DNAemia, detected by polymerase chain reaction (PCR), and VZV-specific effector (Teff) and memory (Tmem) T cells, was measured in 67 vaccinees. PCR was positive in 56% (9 direct, 28 nested) on day 1 and in 16% (1 direct, 10 nested) on day 14. Read More

    SUNCT like syndrome preceding acute ophthalmic- distribution zoster: A case report and review of the literature.
    Clin Neurol Neurosurg 2018 Jan 31;166:107-109. Epub 2018 Jan 31.
    Johannes- Wesling- Klinikum Minden, Dept. of Neurology, Ruhr-University Bochum, Hans-Nolte Str. 1, 32429 Minden, DE, Germany.
    Background: SUNCT like syndrome has been observed as a post zoster condition, as a syndrome associated with overt ophthalmic zoster after appearance of herpetic lesions and in varicella zoster virus meningoencephalitis without rash. However, SUNCT like syndrome fully consistent and congruent with the criteria of the ICHD immediately before onset of an ophthalmic-distribution zoster has not been reported.

    Case Presentation: We report 73-year-old patient with a SUNCT like syndrome as the first presentation of an acute ophthalmic-distribution zoster. Read More

    Highly convergent synthesis and antiviral activity of (E)-but-2-enyl nucleoside phosphonoamidates.
    Eur J Med Chem 2018 Feb 31;146:678-686. Epub 2018 Jan 31.
    Univ. Orléans, CNRS, ICOA, UMR 7311, F-45067 Orléans, France. Electronic address:
    Several hitherto unknown (E)-but-2-enyl nucleoside phosphonoamidate analogs (ANPs) were prepared directed with nitrogen reagents by cross-metathesis in water-under ultrasound irradiation. Two diastereoisomers were formally identified by X-ray diffraction. These compounds were evaluated against a large spectrum of DNA and RNA viruses. Read More

    Aetiological study of viruses causing acute encephalitis syndrome in North West India.
    Indian J Med Microbiol 2017 Oct-Dec;35(4):529-534
    Department of Microbiology and Immunology, Advanced Basic Sciences and Clinical Research Laboratory, ICMR Grade 1/ DHR State, Sawai Man Singh Medical College, Jaipur, Rajasthan, India.
    Context: Acute encephalitis syndrome (AES) is a serious public health problem, caused mainly by viruses. However, the profile of viruses causing AES in Rajasthan is not well characterised.

    Aims: The present study was undertaken to identify the viruses causing AES and develop diagnostic algorithm so as to help in improved diagnosis, treatment, prevention and control. Read More

    Varicella zoster virus-associated Chorioretinitis: a case report.
    BMC Ophthalmol 2018 Feb 5;18(1):28. Epub 2018 Feb 5.
    Department of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, Yonsei-ro 50-1, Seodaemun-gu, Seoul, South Korea.
    Background: Chorioretinitis is an unusual form of varicella zoster virus (VZV)-associated uveitis, and no report has described VZV-associated chorioretinitis using serial optical coherence tomography (OCT) images obtained during the course of resolution.

    Case Presentation: A 61-year-old woman presented with acute, unilateral vision loss in her right eye. Her visual acuity was count fingers in the right eye and 16/20 in the left eye, and she exhibited skin vesicles on her right forehead. Read More

    Age-dependent trigeminal and female-specific lumbosacral increase in herpes zoster distribution in the elderly.
    J Dermatol Sci 2018 Jan 31. Epub 2018 Jan 31.
    Department of Virology, University of Toyama, Toyama, 930-0194, Japan.
    Background: Varicella-zoster virus causes herpes zoster (HZ) along specific dermatomes, but the effects of age and sex on HZ distribution are unclear.

    Objective: We investigated the age- and sex-dependent distribution characteristics of HZ.

    Methods: Patients with HZ were monitored by members of the Miyazaki Dermatologist Society. Read More

    Does herpes zoster predispose to giant cell arteritis: a geo-epidemiologic study.
    Clin Ophthalmol 2018 11;12:113-118. Epub 2018 Jan 11.
    Vasculitis Clinic, Rheumatology, Mount Sinai Hospital, Toronto, ON, Canada.
    Purpose: Giant cell arteritis (GCA) is the most common systemic vasculitis in the elderly and can cause irreversible blindness and aortitis. Varicella zoster (VZ), which is potentially preventable by vaccination, has been proposed as a possible immune trigger for GCA, but this is controversial. The incidence of GCA varies widely by country. Read More

    The MRZ reaction helps to distinguish rheumatologic disorders with central nervous involvement from multiple sclerosis.
    BMC Neurol 2018 Jan 31;18(1):14. Epub 2018 Jan 31.
    Department of Rheumatology and Clinical Immunology, Faculty of Medicine, Medical Center - University of Freiburg, Hugstetter Strasse 55, D-79106, Freiburg, Germany.
    Background: Some rheumatologic disorders may initially manifest with central nervous system (CNS) affection, mimicking the clinical, magnetic resonance imaging, and cerebrospinal fluid findings of multiple sclerosis (MS). The MRZ reaction (MRZR), composed of the three respective antibody indices (AIs) against measles, rubella, and varicella zoster virus, has been found positive frequently in MS patients. However, it is unclear whether the MRZR is helpful to distinguish rheumatologic disorders with CNS involvement (RDwCNS) from MS. Read More

    Elevated EBNA-1 IgG in MS is associated with genetic MS risk variants.
    Neurol Neuroimmunol Neuroinflamm 2017 Nov 12;4(6):e406. Epub 2017 Oct 12.
    Department of Neurology (K.L.K., G.P.V.N., M.J., R.Q.H.), MS Center ErasMS (K.L.K., M.J., R.Q.H.), Department of Viroscience (G.P.V.N., S.M.J.S., G.M.G.M.V.), and Department of Immunology (M.J., R.Q.H.), Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
    Objective: To assess whether MS genetic risk polymorphisms (single nucleotide polymorphism [SNP]) contribute to the enhanced humoral immune response against Epstein-Barr virus (EBV) infection in patients with MS.

    Methods: Serum anti-EBV nuclear antigen 1 (EBNA-1) and early antigen D (EA-D) immunoglobulin γ (IgG) levels were quantitatively determined in 668 genotyped patients with MS and 147 healthy controls. Anti-varicella-zoster virus (VZV) IgG levels were used as a highly prevalent, non-MS-associated control herpesvirus. Read More

    Lessons from an Outbreak of Varicella Infection in Pediatric Hemato-Oncology Patients.
    Pediatr Infect Dis J 2018 Jan 25. Epub 2018 Jan 25.
    Pediatric Hemato-Oncology Department, Pediatric Infectious Diseases Unit, and Department of Epidemiology, Tel Aviv Medical Center, Tel Aviv, Israel, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Background: Immunocompromized patients exposed to varicella may experience significant morbidity and a 7% mortality rate. Management and outcome of an outbreak of varicella infection among hospitalized pediatric hemato-oncology patients using the guidelines of the American Academy of Pediatrics Committee on Infectious Diseases is presented.

    Patients And Methods: This retrospective study describes an outbreak of varicella infection between February 2011 and June 2011. Read More

    Disseminated fusariosis emerged from prolonged local genital infection after cord blood transplantation.
    J Infect Chemother 2018 Jan 16. Epub 2018 Jan 16.
    Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan.
    Disseminated fusariosis (DF) is a rare life threatening fungal infection in immunocompromised hosts. We herein report a case of a fatal DF mimicking varicella zoster virus (VZV) infection that was emerged from a localized genital infection during cord blood transplantation (CBT) in a patient with severe aplastic anemia (SAA). The patient developed an ulcer following small painful vesicles mimics herpes simplex virus infection (HSV) on the glans penis before CBT, but a Fusarium species was identified. Read More

    Rapid Detection and Identification of Uveitis Pathogens by Qualitative Multiplex Real-Time PCR.
    Invest Ophthalmol Vis Sci 2018 Jan;59(1):582-589
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, United States.
    Purpose: Infectious uveitis is a serious sight-threatening infection commonly caused by herpesviruses and Toxoplasma gondii. Etiologic diagnosis based on the clinical evaluation is often challenging. We developed and validated a multiplex real-time PCR assay coupled with high-resolution melting (HRM) for rapid detection and identification of herpes simplex viruses 1 and 2 (HSV-1 and HSV-2), varicella-zoster virus (VZV), cytomegalovirus (CMV), and T. Read More

    Modeling the impact of combined vaccination programs against varicella and herpes zoster in Norway.
    Vaccine 2018 Feb 20;36(8):1116-1125. Epub 2018 Jan 20.
    Department of Economics and Management, University of Pisa, Pisa, Italy. Electronic address:
    Background: Adoption of varicella immunization in Europe is limited due to a predicted increase in the incidence of herpes zoster (HZ) resulting from a removal of exogenous boosting by varicella vaccination. Most available assessments of immunization strategies only considered universal varicella vaccination (alone or in combination with HZ by the live vaccine). The development of a new subunit recombinant zoster vaccine may provide new perspectives of HZ control. Read More

    Postherpetic Neuralgia and Trigeminal Neuralgia.
    Pain Res Treat 2017 5;2017:1681765. Epub 2017 Dec 5.
    Department of Periodontology and Oral Medicine, Sefako Makgatho Health Sciences University, Pretoria, South Africa.
    Postherpetic neuralgia (PHN) is an unpredictable complication of varicella zoster virus- (VZV-) induced herpes zoster (HZ) which often occurs in elderly and immunocompromised persons and which can induce psychosocial dysfunction and can negatively impact on quality of life. Preventive options for PHN include vaccination of high-risk persons against HZ, early use of antiviral agents, and robust management of pain during the early stage of acute herpes zoster. If it does occur, PHN may persist for months or even years after resolution of the HZ mucocutaneous eruptions, and treatment is often only partially effective. Read More

    MRI findings of postherpetic abdominal wall pseudohernia: A case report.
    Clin Imaging 2018 Jan 9;50:109-112. Epub 2018 Jan 9.
    Radiology Department, Clínica Dávila, Santiago, Chile.
    Herpes zoster is caused by the reactivation of latent varicella-zoster virus from dorsal root ganglia. Although infrequent, simultaneous damage to the anterior horn cells or anterior nerve roots at the same level may result in motor neuropathy. When motor involvement is localized in the abdominal wall, a pseudohernia may be the clinical presentation. Read More

    Epidemic Varicella Zoster Virus among University Students, India.
    Emerg Infect Dis 2018 Feb;24(2):366-369
    We investigated a yearlong varicella zoster virus outbreak in a highly susceptible young adult population at a large university in India. Outbreaks of varicella infection among adults are not well described in the literature. Infection control measures and vaccination policy for this age group and setting are needed. Read More

    Ramsay Hunt Syndrome with Multiple Cranial Neuropathy in an Human Immunodeficiency Virus (HIV) Patient.
    Am J Case Rep 2018 Jan 18;19:68-71. Epub 2018 Jan 18.
    Department of Neurology, Bronx-Lebanon Hospital, Bronx, NY, USA.
    BACKGROUND Ramsay Hunt syndrome is a rare otologic complication resulting from varicella zoster virus reactivation that can present with a myriad of clinical presentations. Most common being triad of ear pain, vesicles at auricle, and ear canal with same side facial palsy. CASE REPORT We report a case of a 29-year-old male with a human immunodeficiency virus (HIV) infection who presented with left facial palsy, vesicles, pain in the left ear, dysphagia, dizziness, and headache resulting from multiple cranial nerves involvement such as cranial nerve V, VII, VIII, IX, and X. Read More

    Attenuation of Simian Varicella Virus Infection by Enhanced Green Fluorescent Protein in Rhesus Macaques.
    J Virol 2018 Jan 17. Epub 2018 Jan 17.
    Division of Microbiology, Tulane University, Tulane National Primate Research Center, Covington, Louisiana, USA.
    Simian varicella virus (SVV), the primate counterpart of varicella zoster virus, causes varicella (chickenpox), establishes latency in ganglia and reactivates to produce zoster. We previously demonstrated that a recombinant SVV expressing the enhanced green fluorescent protein (rSVV.eGFP) is slightly attenuated both in culture and infected monkeys. Read More

    Mass-spectrometric profiling of cerebrospinal fluid reveals metabolite biomarkers for CNS involvement in varicella zoster virus reactivation.
    J Neuroinflammation 2018 Jan 17;15(1):20. Epub 2018 Jan 17.
    TWINCORE Centre for Experimental and Clinical Infection Research GmbH, Feodor-Lynen-Str. 7, 30625, Hannover, Germany.
    Background: Varicella zoster virus (VZV) reactivation spans the spectrum from uncomplicated segmental herpes zoster to life-threatening disseminated CNS infection. Moreover, in the absence of a small animal model for this human pathogen, studies of pathogenesis at the organismal level depend on analysis of human biosamples. Changes in cerebrospinal fluid (CSF) metabolites may reflect critical aspects of host responses and end-organ damage in neuroinfection and neuroinflammation. Read More

    Utility of ultra-deep sequencing for detection of varicella-zoster virus antiviral resistance mutations.
    Antiviral Res 2018 Jan 12;151:20-23. Epub 2018 Jan 12.
    Persistent Viral Infections Team, U1135, CR7, CIMI-UPMC and AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière - Charles Foix, Service de Virologie, Paris, France. Electronic address:
    We report the first application of ultra-deep sequencing (UDS) to varicella-zoster virus (VZV) genotypic antiviral testing in a case of acyclovir-resistant VZV infection initially detected by Sanger sequencing within a deeply immunocompromised heart transplant recipient. As added-value compared to Sanger analysis, UDS revealed complex dynamics of viral population under antiviral pressure. Varicella-zoster virus (VZV) is a ubiquitous human herpesvirus affecting populations worldwide. Read More

    Ventricular Fibrillation following Varicella Zoster Myocarditis.
    Case Rep Cardiol 2017 23;2017:1017686. Epub 2017 Nov 23.
    University of Cyprus Medical School, Nicosia, Cyprus.
    Varicella-zoster virus (VZV) infection can rarely lead to serious cardiac complications and life-threatening arrhythmias. We present a case of a 46-year-old male patient who developed VZV myocarditis and presented with recurrent syncopal episodes followed by a cardiac arrest. He had a further collapse eight years later, and cardiac magnetic resonance imaging (MRI) demonstrated mild mid-wall basal and inferolateral wall fibrosis. Read More

    infection presenting as stroke and meningoencephalitis with aortic and subclavian aneurysms without pulmonary involvement.
    BMJ Case Rep 2018 Jan 11;2018. Epub 2018 Jan 11.
    Department of Neurology, Rashid Hospital, Dubai, United Arab Emirates.
    A 39-year-old Philipino man presented with acute onset fever and headache. Neurological examination was normal except for neck stiffness. There was no history of chest pain, cough or breathlessness. Read More

    Characteristics of patients with acute peripheral facial palsy showing Varicella zoster virus DNA in saliva.
    J Med Virol 2018 Jan 10. Epub 2018 Jan 10.
    Department of Otorhinolaryngology, Eulji University Hospital, Eulji University, Daejeon, Republic of Korea.
    Infection caused by Varicella zoster virus (VZV) is a common etiology of acute peripheral facial palsy (APFP). We aimed to assess the clinical significance of detecting VZV DNA from the saliva of patients with APFP. Saliva collected from 36 patients with unilateral APFP at initial visit was analyzed to detect VZV DNA by polymerase chain reaction. Read More

    Opportunistic infections in patients with idiopathic inflammatory myopathies.
    Int J Rheum Dis 2018 Feb 5;21(2):487-496. Epub 2018 Jan 5.
    Internal Medicine Department, Autonomous University of Barcelona, Barcelona, Spain.
    Aim: To describe the prevalence, clinical characteristics and risk factors of opportunistic infection (OI) in a cohort of patients with inflammatory myopathies, and compare mortality rates between those with and without OIs.

    Methods: In total, 204 patients from our myositis cohort were reviewed to identify patients who had experienced an OI during the period 1986-2014. The patients' clinical characteristics, treatments received, and outcomes were systematically recorded. Read More

    Post-varicella Arterial Ischemic Stroke in Denmark 2010 to 2016.
    Pediatr Neurol 2017 Dec 1. Epub 2017 Dec 1.
    Department of Paediatric and Adolescent Medicine, Rigshospitalet, Copenhagen Ø, Denmark.
    Background: Varicella, most often a benign disease of childhood, is associated with an increased risk of arterial ischemic stroke in children. The aim of the present study was to estimate the incidence of post-varicella arterial ischemic stroke in the Danish child population and describe clinical characteristics of children admitted with post-varicella arterial ischemic stroke.

    Methods: In the Danish National Patient Register, we identified inpatients 28 days to 16 years of age with a discharge diagnosis of stroke or cerebrovascular disease from 2010 to 2016. Read More

    Varicella zoster meningitis: an atypical case of zoster reactivation in immunocompetent young adult.
    BMJ Case Rep 2018 Jan 5;2018. Epub 2018 Jan 5.
    Internal Medicine, Charleston Area Medical Center, West Virginia University, Charleston, West Virginia, USA.
    Varicella virus is a neurotropic virus that can reactivate later in life to cause zoster or shingles. Typically, it affects elderly, immunocompromised population. We report an unusual case of an immunocompetent young adult presenting with occipital headache and zoster rash, without preherpetic and postherpetic neuralgia, who was diagnosed with varicella meningitis on Polymerase chain reaction (PCR). Read More

    [Abdominal wall paresis as a complication of herpes zoster].
    Ned Tijdschr Geneeskd 2018 ;162(0):D1949
    VUmc, Amsterdam.
    Background: Herpes zoster is an illness which is especially common amongst the elderly in the Netherlands and which can express itself in various ways. Besides affecting sensory nerves, which leads to postherpetic pain, the varicella zoster virus may also invade motor nerves.

    Case Description: A 73-year-old female went to the surgeon with symptoms of a painful swelling in the left lower abdomen. Read More

    Candidate for a live vaccine?
    J Family Med Prim Care 2017 Apr-Jun;6(2):445-446
    Department of Infectious Disease, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
    Immune dysfunction is a well-known phenomenon in end-stage liver disease (ESLD). The pretransplant period offers a unique window for primary care physicians to optimize the transplant's vaccine protection before antirejection medications are initiated. Live vaccinations are selected cautiously but the varicella-zoster virus (VZV) vaccine, Zostavax, is recommended for pretransplant candidates. Read More

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