The natural history of varicella zoster virus infection in Norway: Further insights on exogenous boosting and progressive immunity to herpes zoster.
- Luigi Marangi,
- Grazina Mirinaviciute,
- Elmira Flem,
- Gianpaolo Scalia Tomba,
- Giorgio Guzzetta,
- Birgitte Freiesleben de Blasio,
- Piero Manfredi
PLoS One 2017 18;12(5):e0176845. Epub 2017 May 18.
Department of Economics and Management, University of Pisa, Pisa, Italy.
We use age-structured models for VZV transmission and reactivation to reconstruct the natural history of VZV in Norway based on available pre-vaccination serological data, contact matrices, and herpes zoster incidence data. Depending on the hypotheses on contact and transmission patterns, the basic reproduction number of varicella in Norway ranges between 3.7 and 5. Read More