10,716 results match your criteria Varicella-Zoster Virus


Corrigendum: Aromatase Derived Estradiol Within the Thalamus Modulates Pain Induced by Varicella Zoster Virus.

Front Integr Neurosci 2018 31;12:66. Epub 2019 Jan 31.

Department of Ophthalmology and of Molecular Microbiology and Genetics, Eye and Ear Foundation, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.

[This corrects the article DOI: 10.3389/fnint.2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fnint.2018.00066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366361PMC
January 2019

Association between statin use and herpes zoster: systematic review and meta-analysis.

BMJ Open 2019 Feb 13;9(2):e022897. Epub 2019 Feb 13.

Department of Cardiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Objective: Statins are commonly prescribed worldwide. In addition to being potent lipid-lowering agents, statins have immunomodulating properties that may increase the risk of varicella zoster virus reactivation. This adverse effect may have substantial public health implications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjopen-2018-022897DOI Listing
February 2019

Evaluation of Next-Generation Sequencing for the Diagnosis of Infections of the Central Nervous System Caused by the Neurotropic Herpes Viruses: A Pilot Study.

Eur Neurol 2019 Feb 14;80(5-6):283-288. Epub 2019 Feb 14.

Medical School of Chinese PLA, Beijing, China.

Background: There are sparse and limited studies on small sample size reporting the application of next-generation sequencing (NGS) in the detection of central nervous system (CNS) viral infections. We assessed the diagnostic performance of NGS of cerebrospinal fluid (CSF) for predicting viral infections of the CNS caused by the neurotropic herpes viruses in a pilot population.

Materials And Methods: We prospectively collected CSF samples from 24 patients with CNS viral infection from April 2017 to October 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000497319DOI Listing
February 2019

Herpes Zoster-induced Progressive Heart Block: A Case Report.

Cureus 2018 Dec 3;10(12):e3674. Epub 2018 Dec 3.

Cardiology, Aventura Hospital and Medical Center, Aventura, USA.

Varicella-zoster virus (VZV) can produce painful, cutaneous lesions in human beings. Reactivation of this neurotropic virus leads to herpes zoster or shingles: a painful, unilateral, vesicular eruption in a restricted dermatomal distribution. Rarely, reactivation of this virus can lead to cardiac complications, such as myocarditis and even conduction abnormalities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.3674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367108PMC
December 2018

Infectious complications and NK cell depletion following daratumumab treatment of Multiple Myeloma.

PLoS One 2019 13;14(2):e0211927. Epub 2019 Feb 13.

Division of Hematology, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.

Treatment with Daratumumab (Dara), a monoclonal anti-CD38 antibody of IgG1 subtype, is effective in patients with multiple myeloma (MM). However, Dara also impairs the cellular immunity, which in turn may lead to higher susceptibility to infections. The exact link between immune impairment and infectious complications is unclear. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211927PLOS
February 2019

Effectiveness of acyclovir prophylaxis against varicella zoster virus disease after allogeneic hematopoietic cell transplantation: A systematic review and meta-analysis.

Transpl Infect Dis 2019 Feb 13:e13061. Epub 2019 Feb 13.

Department of Pediatrics, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa, Japan, 236-0004.

Background: Varicella zoster virus (VZV) disease is a common complication after hematopoietic cell transplantation (HCT). The mortality rate for disseminated VZV infection is 34%. Acyclovir has been used for the prophylaxis of VZV disease after HCT, but the effectiveness of prophylaxis is controversial. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/tid.13061DOI Listing
February 2019

Fatal disseminated visceral Varicella Zoster Virus infection in a renal transplant recipient.

Transpl Infect Dis 2019 Feb 12:e13062. Epub 2019 Feb 12.

Department of Infectious Diseases, The Alfred Hospital and Central Clinical School, Monash University, Melbourne, Australia.

We report a case of fatal disseminated varicella zoster virus (VZV) with delayed-onset rash in a 66-year-old female more than two years following uncomplicated deceased donor renal transplantation. Whilst on a stable regimen of maintenance immunosuppression, the patient presented with chest and abdominal pain with concomitant hepatitis and pancreatitis. After pursuing multiple other potential causes of her symptoms, the correct diagnosis of VZV was only suspected after the development of a widespread vesicular rash - 11 days after her initial symptoms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/tid.13062DOI Listing
February 2019

Incidence and risk factors for herpes zoster after adult liver transplantation.

Ann Surg Treat Res 2019 Feb 30;96(2):95-99. Epub 2018 Jan 30.

Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Purpose: Herpes zoster (HZ) is caused by reactivation of the varicella zoster virus, which occurs frequently in liver transplant recipients with impaired cellular immunity. The purpose of this study was to evaluate the incidence and risk factors for HZ after adult liver transplantation (LT).

Methods: In our institution, 993 patients underwent adult LT from January 1997 to December 2013. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4174/astr.2019.96.2.95DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358591PMC
February 2019

Herpes Zoster in Pregnancy.

J Midwifery Womens Health 2019 Feb 10. Epub 2019 Feb 10.

Vanderbilt University School of Nursing, Nashville, Tennessee.

Herpes zoster (shingles) is the reactivation of dormant varicella zoster virus in individuals who previously experienced varicella infection or vaccination. Herpes zoster can occur in pregnancy, although it is rare. This case report describes the clinical presentation and diagnosis of herpes zoster and reviews current recommendations for treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jmwh.12953DOI Listing
February 2019
1 Read

Safety and immunogenicity of a varicella vaccine without human serum albumin (HSA) versus a HSA-containing formulation administered in the second year of life: a phase III, double-blind, randomized study.

BMC Pediatr 2019 Feb 7;19(1):50. Epub 2019 Feb 7.

GSK, Avenue Fleming 20, B-1300, Wavre, Belgium.

Background: A new formulation of the live-attenuated varicella vaccine Varilrix (GSK) produced without human serum albumin (HSA) was developed to minimize a theoretical risk of transmission of infectious diseases. A previous study showed that the vaccine was immunologically non-inferior to the HSA-containing vaccine and well-tolerated in toddlers; low-grade fever was numerically higher in children receiving the vaccine without HSA, but the study lacked power to conclude on this difference.

Methods: In this phase III, double-blind, multi-center study, healthy 12-23-month-olds were randomized (1:1) to receive two doses of the varicella vaccine without (Var-HSA group) or with HSA (Var + HSA group) at days 0 and 42. Read More

View Article

Download full-text PDF

Source
https://bmcpediatr.biomedcentral.com/articles/10.1186/s12887
Publisher Site
http://dx.doi.org/10.1186/s12887-019-1425-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366055PMC
February 2019
10 Reads

A case report of severe recurrent varicella in an ankylosing spondylitis patient treated with adalimumab - a new side effect after 15 years of usage.

BMC Infect Dis 2019 Feb 7;19(1):127. Epub 2019 Feb 7.

University Hospital for Infectious Diseases "Dr. Fran Mihaljević", Mirogojska 8, 10000, Zagreb, Croatia.

Background: Tumor necrosis factor-α (TNF-α) antagonists, most of which are monoclonal antibodies, became a widespread treatment for autoimmune diseases such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel diseases, psoriasis, psoriatic arthritis, hidradenitis suppurativa and uveitis. Their use is based on the blockage of TNF-α, which plays an important role in granulomas formation, development of phagosomes, activation and differentiation of macrophages, immune response against viral pathogens. The multiple adverse effects of TNF-α inhibition have been identified, including a two-to four-fold increased risk of active tuberculosis and other granulomatous conditions and an increased occurrence of some other serious bacterial, fungal and certain viral infections. Read More

View Article

Download full-text PDF

Source
https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
Publisher Site
http://dx.doi.org/10.1186/s12879-019-3768-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367735PMC
February 2019
2 Reads

Comparison of the whole genome sequence of an Oka varicella vaccine from China with other Oka vaccine strains reveals sites putatively critical for vaccine efficacy.

J Virol 2019 Feb 6. Epub 2019 Feb 6.

NHC Key Laboratory of Medical Virology and Viral Diseases (National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention), WHO WPRO Regional Reference Measles/Rubella Laboratory, Beijing 102206, People's Republic of China.

Varicella-Zoster Virus (VZV) infection results in varicella mostly in children. Reactivation of the virus causes Herpes Zoster (HZ) mostly in adults. A live attenuated vaccine (vOka-Biken hereafter) was originally derived from the parental strain pOka. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JVI.02281-18DOI Listing
February 2019
1 Read

The impact of childhood varicella vaccination on the incidence of herpes zoster in the general population: modelling the effect of exogenous and endogenous varicella-zoster virus immunity boosting.

BMC Infect Dis 2019 Feb 6;19(1):126. Epub 2019 Feb 6.

Department of Experimental Virology, University Hospital Jena, Jena, Germany.

Background: A controversy exists about the potential effect of childhood varicella vaccination on Herpes Zoster (HZ) incidence. Mathematical models projected temporary HZ incidence increase after vaccine introduction that was not confirmed by real-world evidence. These models assume that absence of contacts with infected children would prevent exogenous boosting of Varicella-Zoster-Virus (VZV) immunity and they do not include an endogenous VZV immunity-boosting mechanism following asymptomatic VZV reactivation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12879-019-3759-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366068PMC
February 2019
1 Read

Paediatric Active Enhanced Disease Surveillance (PAEDS) annual report 2016: Prospective hospital-based surveillance for serious paediatric conditions

Commun Dis Intell (2018) 2019 Feb 1;43. Epub 2019 Feb 1.

Director, National Centre for Immunisation Research and Surveillance, Kids Research Institute, The Children’s Hospital at Westmead, New South Wales

Introduction: The Paediatric Active Enhanced Disease Surveillance (PAEDS) network is a hospital-based active surveillance system employing prospective case ascertainment for selected serious childhood conditions, particularly vaccine preventable diseases and potential adverse events following immunisation (AEFI). PAEDS data is used to better understand these conditions, inform policy and practice under the National Immunisation Program, and enable rapid public health responses for certain conditions of public health importance. PAEDS enhances data available from other Australian surveillance systems by providing prospective, detailed clinical and laboratory information on children with selected conditions. Read More

View Article

Download full-text PDF

Source
February 2019

Premedication With Gabapentin Significantly Reduces the Risk of Postherpetic Neuralgia in Patients With Neuropathy.

Mayo Clin Proc 2019 Feb 1. Epub 2019 Feb 1.

Department of Dermatology, Mayo Clinic, Scottsdale, AZ. Electronic address:

Postherpetic neuralgia (PHN) is the most common complication of varicella zoster virus (VZV) reactivation and a cause of considerable physical and psychosocial morbidity. No known treatment effectively prevents the development of PHN in patients with VZV reactivation. In this study, our objective was to evaluate the efficacy of premedication with gabapentin for reducing the risk of PHN in patients with diabetic and nondiabetic neuropathy. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00256196183088
Publisher Site
http://dx.doi.org/10.1016/j.mayocp.2018.11.004DOI Listing
February 2019
6 Reads

Post-herpes neurotrophic keratopathy: Aetiopathogenesis, clinical signs and current therapies.

Arch Soc Esp Oftalmol 2019 Feb 1. Epub 2019 Feb 1.

Departamento de Oftalmología, Hospital Ramón y Cajal, Madrid, España.

Neurotrophic keratopathy (NK) is a degenerative corneal disease caused by damage of trigeminal innervation. This leads to epithelial defects, ulceration and, eventually, perforation. Both herpes simplex and varicella zoster keratitis are reported to be the main causes of NK. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oftal.2019.01.002DOI Listing
February 2019
1 Read

Identification of the Epstein Barr Virus portal.

Virology 2019 Jan 10;529:152-159. Epub 2019 Jan 10.

Department of Biomedical Sciences, Mercer University School of Medicine, Savannah, GA 31404, USA.

Little is known about Epstein Barr Virus (EBV) proteins that participate in viral DNA cleavage and packaging. Genes encoding potential terminase subunit and portal protein homologs include BGRF1/BDRF1, BALF3, BFRF1A and BBRF1 respectively. EBV mutants with deletions in one or more of these genes were impaired for DNA packaging (Pavlova et al. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.virol.2019.01.003DOI Listing
January 2019
1 Read

Rethinking the causes of pain in herpes zoster and postherpetic neuralgia: the ectopic pacemaker hypothesis.

Authors:
Marshall Devor

Pain Rep 2018 Nov 7;3(6):e702. Epub 2018 Nov 7.

Department of Cell and Developmental Biology, Institute of Life Sciences, and Center for Research on Pain, The Hebrew University of Jerusalem, Jerusalem, Israel.

Introduction: Pain in herpes zoster (HZ) and postherpetic neuralgia (PHN) is traditionally explained in terms of 2 processes: irritable nociceptors in the rash-inflamed skin and, later, deafferentation due to destruction of sensory neurons in one virally infected dorsal root ganglion.

Objectives And Methods: Consideration of the evidence supporting this explanation in light of contemporary understanding of the pain system finds it wanting. An alternative hypothesis is proposed as a replacement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PR9.0000000000000702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344138PMC
November 2018
1 Read

Ramsay Hunt syndrome with pontine lesion: A case report.

Medicine (Baltimore) 2019 Feb;98(5):e14260

Department of Neurological Function Examination.

Rationale: The coexistence of Ramsay Hunt syndrome (RHS) and varicella-zoster virus (VZV) encephalitis is rare. A patient who developed RHS after being infected with VZV, along with a pontine lesion, is reported in the present study.

Patient Concerns: A 41-year-old male patient presented with his mouth askew for 7 days, and dizziness, accompanied by hearing loss for 3 days. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000014260DOI Listing
February 2019
1 Read
5.723 Impact Factor

CLINICAL-PATHOGENETICAL ROLE OF TOLL-LIKE RECEPTOR 2 (RS 5743708) AND INTERLEUKIN-10 (RS 1800896) GENES POLYMORPHISM IN THE COURSE OF HERPES ZOSTER IN ADULTS.

Georgian Med News 2018 Dec(285):81-86

Zaporizhzhya State Medical University, Ukraine.

The study included 50 adult patients with shingles by which analyzed the clinical course of the disease depending on the gene polymorphism of interleukin-10 (rs 1800896) and toll-like receptor 2 (rs 5743708). According to the results of our study, it was established that genotype AA of gene Toll-like receptor 2 was associated with a high risk of Varicella-Zoster virus reactivation and manifestation of herpes zoster, moderate course. Analysis of the IL-10 gene polymorphism showed that genotype TT was associated with a risk of the development severe complicated course of shingles. Read More

View Article

Download full-text PDF

Source
December 2018
2 Reads

Central nervous system varicella zoster vasculopathy in an immunocompromised patient.

IDCases 2019 29;15:e00483. Epub 2018 Dec 29.

Infectious Diseases Department, Centro Hospitalar Universitário São João, Oporto, Portugal.

Central nervous system (CNS) vasculopathy associated with Varicella Zoster Virus (VZV) infection, usually manifesting as stroke due to ischemic lesions by involvement of small arteries, is frequently misdiagnosed. Immunocompromised patients have a particularly higher risk of severe disease and also CNS involvement during or following VZV presentations. We report a case of an 84-year-old man, with myelodysplastic syndrome, who presented with herpes zoster ophthalmicus complicated with left periocular cellulitis and an abnormal neurological exam. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.idcr.2018.e00483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348231PMC
December 2018
1 Read

Anti-NMDAR encephalitis with concomitant varicella zoster virus detection and nonteratomatous malignancy.

Neurol Neuroimmunol Neuroinflamm 2019 Mar 9;6(2):e537. Epub 2018 Jan 9.

Department of Internal Medicine (P.A.P., K.M.), Department of Neurology (J.J., T.G., J.S.K.), Department of Anesthesia (W.C.T.), and Department of Pulmonary, Critical Care, and Sleep Medicine (P.P.), Baylor College of Medicine; and National School of Tropical Medicine (J.E.W.), Baylor College of Medicine, Houston, TX.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1212/NXI.0000000000000537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340333PMC
March 2019
1 Read

Virus detection in the cerebrospinal fluid of hematopoietic stem cell transplant recipients is associated with poor patient outcomes: a CIBMTR contemporary longitudinal study.

Bone Marrow Transplant 2019 Jan 29. Epub 2019 Jan 29.

Division of Hematology/Oncology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Limited data exist on characteristics of central nervous system viruses (CNS-V) in allogeneic hematopoietic stem cell transplant (HCT) recipients. Between 2007 and 2015, the Center for International Blood and Marrow Transplant Research (CIBMTR) received information on 27,532 patients undergoing HCT. Of these, centers reported 165 HCT recipients with CNS-V detected in cerebrospinal fluid within 6 months after HCT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41409-019-0457-9DOI Listing
January 2019
2 Reads

Herpes zoster presenting as unilateral vasculitis.

Dermatol Online J 2018 Nov 15;24(11). Epub 2018 Nov 15.

Department of Dermatology, Oregon Health and Science University, Portland, Oregon.

Vasculitis can be a primary disorder or a cutaneous manifestation of a viral infection. The present case describes an atypical localized cutaneous varicella-zoster virus infection inducing a small vessel vasculitis in a patient with multisystem sarcoidosis. Additionally, we discuss the differential diagnoses and treatment options. Read More

View Article

Download full-text PDF

Source
November 2018
1 Read

Serological and T Cell Responses After Varicella Zoster Virus Vaccination in HIV-Positive Patients Undergoing Renal Dialysis.

Viral Immunol 2019 Jan 29. Epub 2019 Jan 29.

1 Infectious Diseases Division, Udine Healthcare and University Integrated Trust, Udine, Italy.

Limited data on varicella zoster virus (VZV) vaccine responses are available in HIV-positive adults, especially among those with end-stage renal disease on dialysis or undergoing kidney transplantation (KT). Serological and T cell responses were analyzed using anti-VZV IgG titers, enzyme-linked immunosorbent assay and flow cytometric intracellular cytokine staining (ICS) in two HIV-positive kidney transplant candidates undergoing dialysis and receiving VZV immunization. The results were compared with two HIV-positive and two HIV-negative VZV-seropositive patients (two kidney transplant candidates and two kidney transplant recipients), and with one HIV-negative vaccinee. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/vim.2018.0112DOI Listing
January 2019

Transmembrane regions of bovine herpesvirus 1-encoded UL49.5 and glycoprotein M regulate complex maturation and ER-Golgi trafficking.

J Gen Virol 2019 Jan 29. Epub 2019 Jan 29.

1​Laboratory of Virus Molecular Biology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, Gdańsk, Poland.

Bovine herpesvirus 1 (BoHV-1)-encoded UL49.5 (a homologue of herpesvirus glycoprotein N) can combine different functions, regulated by complex formation with viral glycoprotein M (gM). We aimed to identify the mechanisms governing the immunomodulatory activity of BoHV-1 UL49. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/jgv.0.001224DOI Listing
January 2019

Current In Vitro Models to Study Varicella Zoster Virus Latency and Reactivation.

Viruses 2019 Jan 26;11(2). Epub 2019 Jan 26.

Institute of Virology, Hannover Medical School, 30625 Hannover, Germany.

Varicella zoster virus (VZV) is a highly prevalent human pathogen that causes varicella (chicken pox) during primary infection and establishes latency in peripheral neurons. Symptomatic reactivation often presents as zoster (shingles), but it has also been linked to life-threatening diseases such as encephalitis, vasculopathy and meningitis. Zoster may be followed by postherpetic neuralgia, neuropathic pain lasting after resolution of the rash. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/v11020103DOI Listing
January 2019
1 Read

Hemorrhagic shock resulting from varicella zoster gastritis in a non-immunocompromised patient.

Int J Infect Dis 2019 Jan 25. Epub 2019 Jan 25.

Service de Réanimation Médicale, Hôpitaux Universitaires Henri Mondor-Albert Chenevier, Assistance Publique-Hôpitaux de Paris, Créteil, France; Groupe de Recherche Clinique CARMAS, Université Paris-Est Créteil, IMRB, Créteil, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijid.2019.01.042DOI Listing
January 2019
1 Read
2.330 Impact Factor

Seroprevalence of varicella-zoster virus among pregnant women in Fayoum Governorate, Egypt.

J Egypt Public Health Assoc 2019 7;94(1). Epub 2019 Jan 7.

3Obstetric and Gynecological Department, Faculty of Medicine, Fayoum University, Faiyum, Egypt.

Background: Chickenpox infection acquired during pregnancy is a serious condition. There may be congenital malformations and neonatal varicella syndrome with significant morbidity and mortality. Egypt has no routine varicella-zoster vaccination program. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s42506-018-0002-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325979PMC
January 2019
4 Reads

Antiviral activity spectrum of phenoxazine nucleoside derivatives.

Antiviral Res 2019 Mar 23;163:117-124. Epub 2019 Jan 23.

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117997, Russia. Electronic address:

The phenoxazine scaffold is widely used to stabilize nucleic acid duplexes, as a part of fluorescent probes for the study of nucleic acid structure, recognition, and metabolism, etc. Here we present the synthesis of phenoxazine-based nucleoside derivatives and their antiviral activity against a panel of structurally diverse viruses: enveloped DNA herpesviruses varicella zoster virus (VZV) and human cytomegalovirus, enveloped RNA tick-borne encephalitis virus (TBEV), and non-enveloped RNA enteroviruses. Studied compounds were effective against DNA and RNA viruses reproduction in cell culture. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.antiviral.2019.01.010DOI Listing
March 2019
2 Reads

Coinfections and differential diagnosis in immunocompetent patients with uveitis of infectious origin.

BMC Infect Dis 2019 Jan 25;19(1):91. Epub 2019 Jan 25.

GEPAMOL, Centro de Investigaciones Biomédicas, Facultad de Ciencias de la Salud, Universidad del Quindío, Armenia, Colombia.

Background: Making a definite diagnosis of infectious uveitis is a challenging task because many other infectious, and non-infectious uveitis, may have similar non-specific symptoms and overlapping clinical appearances. Co-infections in immunocompetent patients are not frequently proved with traditional serologic-diagnostic tools.

Methods: Descriptive transversal study, in a Uveitis Service of an Ophthalmology Reference Center, in Bogotá, Colombia, from July 2014 to February 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12879-018-3613-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347798PMC
January 2019
3 Reads

Vaccine strain varicella zoster virus transmitted within a family from a child with shingles results in varicella meningitis in an immunocompetent adult.

Intern Med J 2019 Jan;49(1):132-133

Sunshine Coast University Hospital, Sunshine Coast, Queensland, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/imj.14178DOI Listing
January 2019

The risk of infections in multiple myeloma before and after the advent of novel agents: a 12-year survey.

Ann Hematol 2019 Mar 24;98(3):713-722. Epub 2019 Jan 24.

Klinik für Innere Medizin II, Abt. Hämatologie und Internistische Onkologie, Universitätsklinikum Jena, Jena, Germany.

Infections represent a major cause of morbidity and mortality in multiple myeloma and are linked to both therapy- and disease-related factors. Although it has been suggested that the rate of infections increased since the introduction of novel agents, controversies still exist. To better assess the risk factors associated with infections in the era of novel agents, we conducted a large retrospective analysis of 479 myeloma patients treated at Jena University Hospital over a period of 12 years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00277-019-03621-1DOI Listing
March 2019
1 Read

Quadruplex real-time PCR for rapid detection of human alphaherpesviruses.

Med Microbiol Immunol 2019 Jan 24. Epub 2019 Jan 24.

Sektion Experimentelle Virologie, Institut für Medizinische Mikrobiologie, Universitätsklinikum Jena, Hans-Knöll-Strasse 2, 07745, Jena, Germany.

Infections with the herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) as well as with the varicella-zoster virus (VZV) may take a serious course. Thus, rapid and reliable detection of these alphaherpesviruses is urgently needed. For this, we established a qualitative quadruplex real-time polymerase chain reaction (PCR) covering HSV-1, HSV-2, VZV and endogenous human glyceraldehyde 3-phosphate dehydrogenase (GAPDH). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00430-019-00580-2DOI Listing
January 2019
1 Read

Varicella zoster virus reactivation and the increased risk of cerebrovascular accidents: the unexpected role dermatologists can play.

Dermatol Online J 2018 Aug 15;24(8). Epub 2018 Aug 15.

Dermatology Department, Hospital de Santarem EPE, Santarem.

Varicella zoster virus (VZV) primary infection usually causes varicella and its reactivation may lead to different clinical manifestations depending on the site of viral reactivation and its subsequent tissue spread. There is a growing recognition of the association between VZV reactivation and ensuing cerebrovascular accidents (CVA). The virus can spread to cerebral arteries, causing a wide clinical spectrum related to VZV vasculopathy. Read More

View Article

Download full-text PDF

Source
August 2018
1 Read

Varicella zoster virus reactivation antedating ipsilateral brainstem stroke.

Dermatol Online J 2018 Aug 15;24(8). Epub 2018 Aug 15.

Department of Biomedical, Metabolic, Neural Sciences, University Hospital of Modena.

itor Title: Varicella zoster virus reactivation antedating ipsilateral brainstem stroke Authors: Giuliana Galassi1, Maurilio Genovese2, Marisa Meacci3, Marcella Malagoli2 Affiliations: 1Department of Biomedical, Metabolic, Neural Sciences, University Hospital of Modena, Italy, 2Neuroradiology Service, University Hospital of Modena, Italy, 3Department of Laboratory Medicine and Patholgy, Microbiology and Virology Unit, University Hospital of Modena, Italy Corresponding Author: Giuliana Galassi, MD, Department of Biomedical, Metabolic, Neural Sciences, University Hospital of Modena, Via P. Giardini 1455, Modena, Italy, Tel: 39-3497325802, Email: giulianagalassi46@gmail.com Abstract: Varicella zoster virus (VZV) infection and reactivation are associated with a number of neurologic conditions. Read More

View Article

Download full-text PDF

Source
August 2018
1 Read

Immune responses to zoster vaccines.

Hum Vaccin Immunother 2019 Jan 24:1-6. Epub 2019 Jan 24.

a Departments of Pediatrics , University of Colorado Denver School of Medicine, Anschutz Medical Campus , Aurora , CO , USA.

There are two licensed herpes zoster vaccines. One is a live vaccine (ZVL) based on an attenuated varicella-zoster virus (VZV). The other is a recombinant vaccine (RZV) based on the VZV glycoprotein E (gE) combined with AS01B, a multicomponent adjuvant system. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/21645515.2018.1
Publisher Site
http://dx.doi.org/10.1080/21645515.2018.1560918DOI Listing
January 2019
3 Reads

Characterization of Virus-specific Immune Response During Varicella Zoster Virus Encephalitis in a Young Adult.

Clin Infect Dis 2019 Jan 19. Epub 2019 Jan 19.

Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia.

An immunocompetent adult received corticosteroids for chest pain, which later was clinically found to be herpes zoster (HZ). She developed severe disease and rapid viral dissemination that elicited an exceptionally strong varicella zoster virus-specific B-cell and CD8 T-cell response. Clinicians should consider atypical HZ presentation prior to corticosteroid administration. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/cid/advance-article/doi/10.1093/cid
Publisher Site
http://dx.doi.org/10.1093/cid/ciy984DOI Listing
January 2019
3 Reads

Genital Herpes Zoster as Possible Indicator of HIV Infection.

Acta Dermatovenerol Croat 2018 Dec;26(4):337-338

Associate Professor Suzana Ljubojević Hadžavdić, MD, PhD, Department of Dermatology and Venereology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Šalata 4, 10000 Zagreb, Croatia;

Herpes zoster (HZ) is an acute, cutaneous viral infection caused by the reactivation of varicella-zoster virus (VZV) (1). It is a frequent medical condition with an incidence rate of 2-3 cases per 1000 person/years in the general population and 7-10 cases per 1000 person/years after the age of 50 (1,2). Risk factors and triggers for reactivation of HZV have not yet been determined precisely, but are likely to include malignancies, immune deficiencies, solid organ and bone marrow transplant recipients, autoimmune diseases, psychological conditions, emotional stress, human immunodeficiency virus (HIV) infection, and other patients receiving immunosuppressive therapies (1,3). Read More

View Article

Download full-text PDF

Source
December 2018
6 Reads

Herpesviridae Seropositivity in Patients with Multiple Sclerosis: First Polish Study.

Eur Neurol 2019 Jan 18;80(5-6):129-135. Epub 2019 Jan 18.

Department of Neurology, Medical University of Białystok, Białystok, Poland.

Background: Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system that leads to inflammation, demyelination and neurodegeneration. Viral aetiology has been suspected to be an MS trigger for a long time, and herpesviruses (HSs) are among the potential pathogens involved.

Objectives: The present investigation aims to detect the presence of antibodies against the herpes simplex virus (HSV), varicella-zoster virus, Epstein-Barr virus (EBV), human cytomegalovirus (CMV) and human herpesvirus 6 (HHV6) in the serum of MS patients and control individuals in north-eastern Poland. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496402DOI Listing
January 2019
2 Reads

Eye Complications During Dupilumab Treatment for Severe Atopic Dermatitis.

Acta Derm Venereol 2019 01 17. Epub 2019 Jan 17.

Dermatology and Venereology Unit, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, 17176 Stockholm, Sweden.

Dupilumab, the first biologic approved for treatment of atopic dermatitis, has demonstrated significant clinical effect and quality of life-enhancing capacity in clinical trials. In these, dupilumab-associated conjunctivitis where reported in a minority of patients. The present case series describe 10 patients treated with dupilumab where eye complications were very common. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2340/00015555-3121DOI Listing
January 2019
2 Reads

Herpes simplex virus linear endotheliitis in a post-keratoplasty patient: A case report.

Medicine (Baltimore) 2019 Jan;98(3):e14191

Department of Ophthalmology and Visual Science, Daejeon St. Mary's Hospital.

Rationale: To report a case of herpes simplex virus (HSV) linear endotheliitis in a 57-year-old male who had underwent keratoplasty 10 years ago. The characteristic linear keratic precipitates (KPs) resembled the Khodadoust line in graft rejection. The differential diagnosis is essential, because the treatment regimen is different between HSV linear endotheliitis and graft rejection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000014191DOI Listing
January 2019
1 Read

Models for optimally controlling varicella and herpes zoster by varicella vaccination: a comparative study.

Med Biol Eng Comput 2019 Jan 16. Epub 2019 Jan 16.

Institute of Clinical Physiology, National Research Council, Via Giuseppe Moruzzi 1, 56124, Pisa, Italy.

The introduction of mass vaccination against Varicella-Zoster-Virus (VZV) is being delayed in many European countries mainly because of the "fear" of a subsequent boom in natural herpes zoster (HZ) incidence in the first decades after the initiation of vaccination, caused by the expected decline in the protective effect of natural immunity boosting due to reduced virus circulation. Optimal control theory has proven to be a successful tool in understanding ways to curtail the spread of infectious diseases by devising the optimal disease intervention strategies. In this paper, we describe how a reduced 'toy' model can extract the essentials of the dynamics of the VZV transmission and reactivation in case of the study of optimal paths of varicella immunization programs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11517-018-1938-5DOI Listing
January 2019
2 Reads

Induction of Immune Response and Protective Immunity by a Local Isolated Varicella Virus in Animal Model: A Future Candidates for Vaccine Production.

Iran J Allergy Asthma Immunol 2018 Dec 31;17(6):586-593. Epub 2018 Dec 31.

Human Viral Vaccine Department, Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran.

Preparation of the indigenous varicella zoster vaccine could significantly reduce the disease burden of varicella zoster virus especially in immunosuppressed children. To achieve this goal, the varicella zoster virus was isolated from an 8 years boy infected with chicken pox. The virus was cultivated in sensitive cell line and determined varicella zoster. Read More

View Article

Download full-text PDF

Source
December 2018
2 Reads

Post-mortem detection of six human herpesviruses (HSV-1, HSV-2, VZV, EBV, CMV, HHV-6) in trigeminal and facial nerve ganglia by PCR.

PeerJ 2019 9;6:e6095. Epub 2019 Jan 9.

Department of Infectious Diseases and Neuroinfections, Medical University of Bialystok, Białystok, Poland.

Background: Among over 100 types of viruses, eight can infect humans: herpes simplex viruses (HSV-1, HSV-2), varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr virus (EBV), and human herpesviruses 6, 7, and 8 (HHV-6, HHV-7, HHV-8). After initial infection, the viruses remain latent for the lifetime of the host. The aim of this study was to determine the distribution of six different herpesviruses: HSV-1, HSV-2, VZV, EBV, CMV, and HHV-6 in trigeminal and facial nerve ganglia among a random group of Polish population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7717/peerj.6095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6330031PMC
January 2019
1 Read

[Pharmacological profiles and clinical effects of amenamevir tablet as treatments for herpes zoster].

Nihon Yakurigaku Zasshi 2019 ;153(1):35-43

Medical Affairs Department, Maruho Co., Ltd.

Herpes zoster is a viral infectious disease caused by reactivation of varicella zoster virus (VZV) in a latently infected ganglion, and is characterized by blistering and pain developing in a zonal region innervated from the ganglion. Amenamevir is an antiherpes agent that does not have a nucleic acid-like structure, and exerts antiviral action by inhibiting the enzymatic activity of a virus-derived helicase-primase complex, which is considered essential for viral DNA replication. Amenamevir is mainly metabolized by CYP3A, and excreted into feces. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1254/fpj.153.35DOI Listing
January 2019
1 Read

Ramsay Hunt syndrome.

J Dent Anesth Pain Med 2018 Dec 28;18(6):333-337. Epub 2018 Dec 28.

Department of Anesthesiology and Pain Medicine, School of Dentistry, Kyungpook National University, Daegu, Republic of Korea.

Ramsay Hunt syndrome is a type of acute herpes zoster, which occurs by reactivation of the varicella-zoster virus at the geniculate ganglion. Clinical presentation of Ramsay Hunt syndrome includes a vesicular rash on the ear (herpes zoster oticus) or in the oral mucosa accompanied by acute peripheral facial nerve paralysis. Other cranial nerves such as V, IX, XI, and XII are often involved. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.17245/jdapm.2018.18.6.333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323042PMC
December 2018
12 Reads

Managing Risks with Biologics.

Curr Gastroenterol Rep 2019 Jan 11;21(2). Epub 2019 Jan 11.

Department of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic, Cleveland, OH, USA.

Purpose Of Review: With a rapidly evolving complement of advanced targeted therapies in inflammatory bowel disease, additional safety and side effect concerns emerge. It is the purpose of this review to consider various risks with biologic therapies in inflammatory bowel disease and discuss mitigating strategies.

Recent Findings: Two recently approved monoclonal antibodies (vedolizumab and ustekinumab) and a Janus kinase inhibitor small molecule (tofacitnib) have introduced a number of novel safety and risk considerations. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11894-019-0669-6
Publisher Site
http://dx.doi.org/10.1007/s11894-019-0669-6DOI Listing
January 2019
12 Reads

T Lymphocytes as Measurable Targets of Protection and Vaccination Against Viral Disorders.

Int Rev Cell Mol Biol 2019 24;342:175-263. Epub 2018 Oct 24.

Department of Medicine, McGill University, Montréal, QC, Canada; Lady Davis Institute, Jewish General Hospital, Montréal, QC, Canada.

Continuous epidemiological surveillance of existing and emerging viruses and their associated disorders is gaining importance in light of their abilities to cause unpredictable outbreaks as a result of increased travel and vaccination choices by steadily growing and aging populations. Close surveillance of outbreaks and herd immunity are also at the forefront, even in industrialized countries, where previously eradicated viruses are now at risk of re-emergence due to instances of strain recombination, contractions in viral vector geographies, and from their potential use as agents of bioterrorism. There is a great need for the rational design of current and future vaccines targeting viruses, with a strong focus on vaccine targeting of adaptive immune effector memory T cells as the gold standard of immunity conferring long-lived protection against a wide variety of pathogens and malignancies. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S19376448183008
Publisher Site
http://dx.doi.org/10.1016/bs.ircmb.2018.07.006DOI Listing
October 2018
9 Reads