56 results match your criteria Vanishing Twin Syndrome


Risks of nonchromosomal birth defects, small-for-gestational age birthweight, and prematurity with in vitro fertilization: effect of number of embryos transferred and plurality at conception versus at birth.

J Assist Reprod Genet 2021 Apr 5;38(4):835-846. Epub 2021 Feb 5.

Epidemiology Program, Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, TX, USA.

Purpose: Excess embryos transferred (ET) (> plurality at birth) and fetal heartbeats (FHB) at 6 weeks' gestation are associated with reductions in birthweight and gestation, but prior studies have been limited by small sample sizes and limited IVF data. This analysis evaluated associations between excess ET, excess FHB, and adverse perinatal outcomes, including the risk of nonchromosomal birth defects.

Methods: Live births conceived via IVF from Massachusetts, New York, North Carolina, and Texas included 138,435 children born 2004-2013 (Texas), 2004-2016 (Massachusetts and North Carolina), and 2004-2017 (New York) were classified by ET and FHB. Read More

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Network for Therapy in Rare Epilepsies (NETRE): Lessons From the Past 15 Years.

Front Neurol 2020 14;11:622510. Epub 2021 Jan 14.

Institute for Transition, Rehabilitation and Palliation, Paracelsus Medical University, Salzburg, Austria.

In 2005, twork for herapy in are pilepsies (NETRE)-was initiated in order to share treatment experiences among clinicians in patients with rare epilepsies. Here we describe the structure of the rapidly growing NETRE and summarize some of the findings of the last 15 years. NETRE is organized in distinct groups (currently >270). Read More

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January 2021

Associations between first-trimester intrauterine hematoma and twin pregnancy outcomes: a retrospective cohort study.

BMC Pregnancy Childbirth 2021 Jan 11;21(1):46. Epub 2021 Jan 11.

Department of Obstetrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, Guangdong Province, China.

Background: In recent years, first-trimester intrauterine hematoma (IUH) has become increasingly common in twin pregnancy. The majority of studies on IUH have excluded twin pregnancies, and others did not differentiate between singleton and twin pregnancies. The impact of IUH on twin pregnancy is unclear. Read More

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January 2021

Retrospective details of false-positive and false-negative results in non-invasive prenatal testing for fetal trisomies 21, 18 and 13.

Eur J Obstet Gynecol Reprod Biol 2021 Jan 27;256:75-81. Epub 2020 Oct 27.

Department of Obstetrics and Gynaecology, Chugokudenryoku Hospital, Hiroshima, Japan.

Objective: Maternal characteristics and neonatal outcomes associated with cell-free DNA (cfDNA) results were analysed retrospectively to assess the details of false-positive and false-negative results after initial blood sampling in non-invasive prenatal testing (NIPT).

Study Design: A multicentre retrospective study was performed for women undergoing NIPT who received discordant cfDNA results between April 2013 and March 2018. The NIPT data obtained using massive parallel sequencing were studied in terms of maternal background, fetal fraction, z-scores, invasive procedure results and neonatal outcomes after birth. Read More

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January 2021

Early and late pregnancy loss in women with polycystic ovary syndrome undergoing IVF/ICSI treatment: a retrospective cohort analysis of 21 820 pregnancies.

BJOG 2021 Jun 19;128(7):1160-1169. Epub 2020 Nov 19.

Assisted Reproduction Centre, Northwest Women and Children's Hospital, Xi'an, China.

Objective: To examine early and late pregnancy loss in women with and without polycystic ovary syndrome (PCOS) undergoing IVF/ICSI transfers.

Design: Retrospective cohort study.

Setting: Reproductive medicine centre at a tertiary hospital. Read More

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Applications of noninvasive prenatal testing in vanishing twin syndrome pregnancies after treatment of assisted reproductive technology in a single center.

Prenat Diagn 2021 Jan 30;41(2):226-233. Epub 2020 Nov 30.

Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China.

Objective: The objective of the study is to assess the clinical application of noninvasive prenatal testing (NIPT) for VTS pregnancies after the treatment of assisted reproductive technology (ART).

Method: This was a retrospective study on VTS pregnancies through ART treatment. Participants underwent NIPT at 11 to 13 weeks gestation by sequencing. Read More

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January 2021

Is vanishing twin syndrome associated with adverse obstetric outcomes of ART singletons? A systematic review and meta-analysis.

J Assist Reprod Genet 2020 Nov 25;37(11):2783-2796. Epub 2020 Aug 25.

Department of Pathology, Medical School, Xi'an Jiaotong University, Xi'an, 710061, China.

Purpose: The objective of our meta-analysis was to estimate the effect of VTS on obstetric outcomes of ART singletons.

Methods: PubMed, Embase, MEDLINE, and ClinicalTrials.gov were searched up to January 2019 to find studies reporting the obstetric outcomes of ART singletons with VTS. Read More

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November 2020

Comparison of the rates of preterm birth and low birth weight of vanishing twin and primary pregnancies conceived with assisted reproductive technology.

J Perinat Med 2020 Aug 17;49(1):50-53. Epub 2020 Aug 17.

Department of Obstetrics and Gynecology, Hebei Xingtai Infertility Hospital, Xingtai, Hebei, P.R. China.

Objectives: The purpose of this study was to compare the rate of preterm birth, low birth weight, and foetal growth restriction in assisted reproductive technology (ART) singleton pregnancies diagnosed with vanishing twin (VT) syndrome to those of ART pregnancies that were originally singleton pregnancies.

Methods: In this retrospective study, 177 pregnancies diagnosed with VT syndrome were matched and compared with 218 primary singleton pregnancies. The preterm birth and low birth weight rates of these two groups were evaluated. Read More

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Vanishing Twins Conceived Through Fresh In Vitro Fertilization: Obstetric Outcomes and Placental Pathology.

Obstet Gynecol 2020 06;135(6):1426-1433

Massachusetts General Hospital Fertility Center and Harvard Medical School, Boston, Massachusetts; the Department of Women's Health, Wright Patterson Air Force Base, Wright Patterson AFB, and the Department of Obstetrics & Gynecology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio; the Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts; CellNetix Pathology and Laboratories and Swedish Medical Center, Seattle, Washington; and the Deborah Kelly Center for Outcomes Research, the Division of Maternal Fetal Medicine, Department of Obstetrics & Gynecology, and the Department of Obstetrics & Gynecology, Massachusetts General Hospital, Boston, Reproductive Endocrinology/Infertility, Department of Obstetrics & Gynecology, UMass Memorial Medical Center, Worcester, Boston IVF, Waltham, and the Department of Obstetrics & Gynecology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

Objective: To characterize the obstetric outcomes and placental pathology in live births arising from vanishing twin pregnancies compared with nonreduced in vitro fertilization (IVF) pregnancies.

Methods: This is a retrospective cohort study of live births resulting from fresh embryo transfers after IVF cycles with autologous oocytes from 2004 through 2017 at a large academic fertility center. Clinical information and pathology reports were reviewed. Read More

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Clinical performance of DNA-based prenatal screening using single-nucleotide polymorphisms approach in Thai women with singleton pregnancy.

Mol Genet Genomic Med 2020 07 24;8(7):e1256. Epub 2020 Apr 24.

Department of Obstetrics and Gynecology, Mahidol University, Bangkok, Thailand.

Background: To review the performance of noninvasive prenatal screening (NIPS) using targeted single-nucleotide polymorphisms (SNPs) approach in mixed-risk Thai women.

Methods: Retrospective analysis of data for detection of trisomy 21 (T21), 18 (T18), 13 (T13), monosomy X (XO), other sex chromosome aneuploidies (SCA), and triploidy/vanishing twins (VT) from a single commercial laboratory.

Results: Mean (±SD) gestational age and maternal weight were 13. Read More

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Neonatal outcomes of singleton live births with vanishing twin syndrome following double embryos transfer in assisted reproductive technology: a retrospective cohort study.

J Ovarian Res 2019 Jul 20;12(1):67. Epub 2019 Jul 20.

The Third Affiliated Hospital of Zhengzhou University, Zhengzhou City, China.

Background: Women with vanishing twin syndrome are associated with increased risks of adverse neonatal outcomes, such as preterm birth (PTB) and low birthweight (LBW), compared with those in singleton live births following single embryo transfer (SET) in assisted reproductive technology (ART).

Methods: Anonymized data on all cycles performed in China were obtained from the Reproductive Medicine Department at the Third Affiliated Hospital of Zhengzhou University, which had involved 127597 cycles following double embryos transfer (DET), including 54585 fresh embryos transfer (ET) cycles and 73012 frozen embryos transfer (FET) cycles. In addition, the obstetric outcomes, such as gestation age, PTB, small for gestation age (SGA), birthweight (BW), LBW, congenital malformation, pediatric admission and Neonatal Intensive Care Unit (NICU) admission in the fresh ET and FET cycles, were analyzed. Read More

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Congenital Laser-Induced Burns: A Potential Complication after Laser Photocoagulation in Monochorionic Twin Pregnancy.

Fetal Pediatr Pathol 2019 Aug 3;38(4):340-344. Epub 2019 Apr 3.

a Department of Neonatology, Hospital 12 de Octubre, Biomedical Research Institute i + 12 , Madrid , Spain.

Fetoscopic laser photocoagulation can directly injure fetal skin and may at birth resemble aplasia cutis congenita (ACC). A twin monochorionic pregnancy was complicated by twin-to-twin transfusion syndrome requiring in utero laser photocoagulation, resulting in the death of one twin. After birth, the viable baby presented skin lesions in both legs that were congruent with laser-induced burns. Read More

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Discordant sex between fetal screening and postnatal phenotype requires evaluation.

J Perinatol 2019 01 21;39(1):28-33. Epub 2018 Nov 21.

Department of Pediatrics, Division of Genetic Medicine, University of Washington, Seattle, WA, USA.

Objective: Non-invasive prenatal screening (NIPS) utilizes circulating cell-free DNA (cfDNA) to screen for fetal genetic abnormalities. NIPS is the first widely-available prenatal screen to assess genotypic sex. Most pediatricians have limited familiarity with NIPS technology and potential etiologies of discordant results. Read More

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January 2019

Follow-Up Studies of cf-DNA Testing from 101 Consecutive Fetuses and Related Ultrasound Findings.

Ultraschall Med 2020 Apr 25;41(2):175-185. Epub 2018 Sep 25.

Women Health Centre, MEDIZON, Istanbul, Turkey.

Purpose:  To determine the true- and false-positive rates of cf-DNA testing in a cohort of patients from tertiary care centers and assess the impact of ultrasound examinations in pregnancy management.

Materials And Methods:  Clinical, cytogenetic and ultrasound data of 101 consecutive fetuses were collected retrospectively. Cases were classified into five groups according to the ultrasound findings. Read More

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The association between the number of oocytes retrieved for IVF, perinatal outcome and obstetric complications.

Hum Reprod 2018 10;33(10):1939-1947

Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Reproductive Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.

Study Question: Is there an association between the number of oocytes retrieved for IVF, and perinatal and obstetric outcomes?

Summary Answer: No significant association was found between the number of oocytes retrieved and perinatal outcomes, while an association was found for placenta praevia and male gender.

What Is Known Already: Previous studies have shown that between 6 and 15 oocytes retrieved is optimal for the live birth rate in fresh cycles. In a recent study, we showed that the cumulative live birth rate, including fresh and all cryopreservation cycles following one OPU, increases by the number of oocytes retrieved, up to approximately 20 oocytes. Read More

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October 2018

Non-Invasive Prenatal Testing (NIPT) in pregnancies with trisomy 21, 18 and 13 performed in a public setting - factors of importance for correct interpretation of results.

Eur J Obstet Gynecol Reprod Biol 2018 Jul 1;226:35-39. Epub 2018 May 1.

Fetal Medicine Unit, Department of Obstetrics and Gynecology, Copenhagen University Hospital Hvidovre, Denmark; Hvidovre Hospitals NIPT Center, Copenhagen University Hospital Hvidovre, Denmark.

Objectives: We have established an open source platform for non-invasive prenatal testing (NIPT) based on massively parallel whole-genome sequencing in a public setting. The objective of this study was to investigate factors of importance for correct interpretation of NIPT results to ensure a high sensitivity and specificity.

Study Design: This investigation is a retrospective case-control study performed in a public NIPT center. Read More

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Biological explanations for discordant noninvasive prenatal test results: Preliminary data and lessons learned.

Prenat Diagn 2018 05;38(6):445-458

Mother Infant Research Institute, Tufts Medical Center, Boston, MA, USA.

Objective: Maternal plasma cell-free DNA (cfDNA) analysis is a powerful screening tool for Down syndrome. In a pilot series, we examined biologic causes of discordance between the cfDNA test results and the fetal karyotype. We also explored the feasibility of obtaining trio biospecimens by using parental engagement. Read More

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Maternal and perinatal outcomes of dichorionic diamniotic twin pregnancies diagnosed with vanishing twin syndrome: a retrospective analysis from a single clinical center.

Ginekol Pol 2018 ;89(1):30-34

University of Health Sciences, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.; Ordu university.

Objectives: Multiple pregnancies are known to be associated with adverse maternal and perinatal complications. How-ever, data regarding the outcomes of spontaneously reduced twin pregnancies are limited. In the current study we aimed to evaluate the consequences of the vanishing twin syndrome (VTS) in dichorionic diamniotic twin pregnancies for both mother and baby in our perinatal center. Read More

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Vanishing twin syndrome among ART singletons and pregnancy outcomes.

Hum Reprod 2017 11;32(11):2298-2304

Centre for Fertility and Health (CeFH), Centre of Excellence at Norwegian Institute of Public Health, P.O. Box 4404 Nydalen, N-0403 Oslo, Norway.

Study Question: Among babies born by ART, do singleton survivors of a vanishing twin have lower birth weight than other singletons?

Summary Answer: Vanishing twin syndrome (VTS) was associated with lower birth weight among ART singletons; a sibship analysis indicated that the association was not confounded by maternal characteristics that remain stable between deliveries.

What Is Known Already: Previous studies indicate that ART singletons with VTS have increased risk of adverse pregnancy outcomes, compared with other ART singletons. The potential contribution of unmeasured maternal background characteristics has been unclear. Read More

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November 2017

The Vanishing Twin Syndrome: Two Cases of Extreme Malformations Associated With Vanished Twins.

Pediatr Dev Pathol 2017 Jul-Aug;20(4):348-353. Epub 2017 Jan 25.

2 Division of Anatomic Pathology, Department of Pathology, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.

Two cases of devastating fetal malformations associated with vanished monochorionic twins were identified upon review of pathology files. A 35-year-old G1P0 woman and 36-year-old G3P1 woman were both diagnosed with an intrauterine twin gestation via transvaginal ultrasound at 10 weeks. The spectrum of fetal anomalies ranged from omphalocele, bilateral upper extremity, and unilateral lower extremity hypoplasia, to craniofacial malformation with diaphragmatic hernia. Read More

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Oliver Sacks: Our Correspondence About Twins/Twin Research: Vanishing Twins Syndrome; Discordant Sex in MZ Twins; Pregnancy Outcomes in IVF and ICSI Conceived Twins/Print and Media: Superfetated Twins; Twins Discordant for Smoking; Twins in Fashion; Yale University Twin Hockey Players; Conjoined Twin-Visiting Professor.

Authors:
Nancy L Segal

Twin Res Hum Genet 2017 08;20(4):363-369

Department of Psychology,California State University,Fullerton,CA,USA.

The late neurologist and author, Oliver Sacks, published an insightful 1986 review of Marjorie Wallace's book, The Silent Twins, in the New York Times. Taking exception to his assertion about Sir Francis Galton, I wrote a letter to the Times' editor. The letter was unpublished, but it brought a wonderful response from Sacks himself that is reproduced and examined. Read More

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Perinatal Risks Associated with Early Vanishing Twin Syndrome following Transfer of Cleavage- or Blastocyst-Stage Embryos.

J Pregnancy 2016 22;2016:1245210. Epub 2016 Dec 22.

The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, NY, USA.

. To investigate whether the perinatal risks associated with early vanishing twin (VT) syndrome differ between cleavage- or blastocyst-stage embryo transfers (ET) in fresh in vitro fertilization (IVF) cycles. . Read More

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Obstetric outcome of vanishing twins syndrome: a systematic review and meta-analysis.

Arch Gynecol Obstet 2017 Mar 17;295(3):559-567. Epub 2017 Jan 17.

Center of Reproductive Medicine, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.

Purpose: Due to the high number of multiple embryo transfers into the uterus performed in assisted reproductive technology treatment (ART), the incidences of twin pregnancy and of vanishing twin syndrome (VTS) are correspondingly high. A number of studies have described the obstetric outcomes of the remaining fetus produced after the other twin had vanished compared with a singleton at the start following ART, but the results are mixed and contradictory. We performed a systematic review of the existing studies to explore the actual obstetric outcome of VTS to allow physicians to adequately advise their patients. Read More

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Early spontaneous multiple fetal pregnancy reduction is associated with adverse perinatal outcomes in in vitro fertilization cycles.

Womens Health (Lond) 2016 07;12(4):420-6

Weill Cornell Medical Center, The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, New York, NY, USA.

The primary objective of this study is to investigate whether early spontaneous multiple fetal pregnancy reduction, also known as vanishing twin syndrome, is associated with adverse perinatal outcomes in fresh in vitro fertilization cycles. This is a retrospective cohort study of women with live singleton births with and without an early vanishing twin after fresh in vitro fertilization. Characteristics compared included incidence of preterm birth, overall birth weight, overall low birth weight, overall very low birth weight, and term low birth weight. Read More

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Analysis of pregnancy outcomes for survivors of the vanishing twin syndrome after in vitro fertilization and embryo transfer.

Eur J Obstet Gynecol Reprod Biol 2016 Aug 20;203:35-9. Epub 2016 May 20.

Reproductive Medicine, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201620, China.

Objective: The purpose of this study was to compare pregnancy outcomes of in vitro fertilization (IVF) singletons diagnosed with vanishing twin syndrome with control pregnancies originating as singleton pregnancies and with twin pregnancies.

Study Design: The current research included 206 survivors of a vanished co-twin, 1730 primary singletons and 662 primary twins. The study group was subdivided according to gestational age at the time of vanishing to give groups of early (≤12 weeks, group A) and late (>12 weeks, group B) survivors. Read More

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Implementation of non-invasive prenatal testing by semiconductor sequencing in a genetic laboratory.

Prenat Diagn 2016 Aug 1;36(8):699-707. Epub 2016 Jul 1.

Center for Medical Genetics Ghent, Ghent University Hospital, Ghent University, Ghent, Belgium.

Objectives: To implement non-invasive prenatal testing (NIPT) for fetal aneuploidies with semiconductor sequencing in an academic cytogenomic laboratory and to evaluate the first 15-month experience on clinical samples.

Methods: We validated a NIPT protocol for cell-free fetal DNA sequencing from maternal plasma for the detection of trisomy 13, 18 and 21 on a semiconductor sequencing instrument. Fetal DNA fraction calculation for all samples and several quality parameters were implemented in the workflow. Read More

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Vanished Twins and Misdiagnosed Sex: A Case Report with Implications in Prenatal Counseling Using Noninvasive Cell-Free DNA Screening.

J Am Board Fam Med 2016 May-Jun;29(3):411-3

From The Department of Family Medicine, Penn State Milton S. Hershey Medical Center, Hershey, PA.

Cell-free DNA testing is a recently introduced method for screening pregnant women for fetal trisomy, which is associated with some common significant genetic diseases, as well as the sex of the fetus. The case described here demonstrates the connection between the ultrasound "vanishing twin" phenomenon and the misdiagnosis of prenatal sex using cell-free DNA testing. Read More

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November 2017

Two consecutive singleton pregnancies versus one twins pregnancy as preferred outcome of in vitro fertilization for mothers and infants: a retrospective case-control study.

Curr Med Res Opin 2016 28;32(4):687-92. Epub 2016 Jan 28.

a Center of Reproductive Medicine and Surgery, Arcispedale Santa Maria Nuova (ASMN) - Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) , Reggio Emilia , Italy ;

Objective: Many infertile couples request a multiple embryo transfer because they desire more than one child. Based on this consideration, the current study aimed to compare the reproductive and perinatal outcomes of two consecutive singleton pregnancies versus one twin pregnancy in a large cohort of in vitro fertilization (IVF) patients.

Research Design And Methods: Retrospective analysis of data from patients with clinical twin pregnancy after IVF fresh cycles and from patients with two consecutive IVF fresh cycles and clinical singleton pregnancy. Read More

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December 2016

Extensive Aplasia Cutis Congenita with Associated Vanishing Twin Syndrome.

J Pediatr 2015 Sep;167(3):772.e1

University of Colorado, Children's Hospital Colorado, Aurora, Colorado.

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September 2015