43 results match your criteria Vanishing Twin Syndrome

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Discordant sex between fetal screening and postnatal phenotype requires evaluation.

J Perinatol 2019 Jan 21;39(1):28-33. Epub 2018 Nov 21.

Department of Pediatrics, Division of Genetic Medicine, University of Washington, Seattle, WA, USA.

Objective: Non-invasive prenatal screening (NIPS) utilizes circulating cell-free DNA (cfDNA) to screen for fetal genetic abnormalities. NIPS is the first widely-available prenatal screen to assess genotypic sex. Most pediatricians have limited familiarity with NIPS technology and potential etiologies of discordant results. Read More

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http://dx.doi.org/10.1038/s41372-018-0278-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340391PMC
January 2019
18 Reads

The association between the number of oocytes retrieved for IVF, perinatal outcome and obstetric complications.

Hum Reprod 2018 10;33(10):1939-1947

Department of Obstetrics and Gynaecology, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Reproductive Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.

Study Question: Is there an association between the number of oocytes retrieved for IVF, and perinatal and obstetric outcomes?

Summary Answer: No significant association was found between the number of oocytes retrieved and perinatal outcomes, while an association was found for placenta praevia and male gender.

What Is Known Already: Previous studies have shown that between 6 and 15 oocytes retrieved is optimal for the live birth rate in fresh cycles. In a recent study, we showed that the cumulative live birth rate, including fresh and all cryopreservation cycles following one OPU, increases by the number of oocytes retrieved, up to approximately 20 oocytes. Read More

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https://academic.oup.com/humrep/article/33/10/1939/5075365
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http://dx.doi.org/10.1093/humrep/dey266DOI Listing
October 2018
25 Reads

Non-Invasive Prenatal Testing (NIPT) in pregnancies with trisomy 21, 18 and 13 performed in a public setting - factors of importance for correct interpretation of results.

Eur J Obstet Gynecol Reprod Biol 2018 Jul 1;226:35-39. Epub 2018 May 1.

Fetal Medicine Unit, Department of Obstetrics and Gynecology, Copenhagen University Hospital Hvidovre, Denmark; Hvidovre Hospitals NIPT Center, Copenhagen University Hospital Hvidovre, Denmark.

Objectives: We have established an open source platform for non-invasive prenatal testing (NIPT) based on massively parallel whole-genome sequencing in a public setting. The objective of this study was to investigate factors of importance for correct interpretation of NIPT results to ensure a high sensitivity and specificity.

Study Design: This investigation is a retrospective case-control study performed in a public NIPT center. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2018.04.042DOI Listing
July 2018
8 Reads

Biological explanations for discordant noninvasive prenatal test results: Preliminary data and lessons learned.

Prenat Diagn 2018 05;38(6):445-458

Mother Infant Research Institute, Tufts Medical Center, Boston, MA, USA.

Objective: Maternal plasma cell-free DNA (cfDNA) analysis is a powerful screening tool for Down syndrome. In a pilot series, we examined biologic causes of discordance between the cfDNA test results and the fetal karyotype. We also explored the feasibility of obtaining trio biospecimens by using parental engagement. Read More

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http://dx.doi.org/10.1002/pd.5260DOI Listing
May 2018
8 Reads

Maternal and perinatal outcomes of dichorionic diamniotic twin pregnancies diagnosed with vanishing twin syndrome: a retrospective analysis from a single clinical center.

Ginekol Pol 2018 ;89(1):30-34

University of Health Sciences, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.; Ordu university.

Objectives: Multiple pregnancies are known to be associated with adverse maternal and perinatal complications. How-ever, data regarding the outcomes of spontaneously reduced twin pregnancies are limited. In the current study we aimed to evaluate the consequences of the vanishing twin syndrome (VTS) in dichorionic diamniotic twin pregnancies for both mother and baby in our perinatal center. Read More

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https://journals.viamedica.pl/ginekologia_polska/article/vie
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http://dx.doi.org/10.5603/GP.a2018.0006DOI Listing
January 2018
18 Reads

Vanishing twin syndrome among ART singletons and pregnancy outcomes.

Hum Reprod 2017 11;32(11):2298-2304

Centre for Fertility and Health (CeFH), Centre of Excellence at Norwegian Institute of Public Health, P.O. Box 4404 Nydalen, N-0403 Oslo, Norway.

Study Question: Among babies born by ART, do singleton survivors of a vanishing twin have lower birth weight than other singletons?

Summary Answer: Vanishing twin syndrome (VTS) was associated with lower birth weight among ART singletons; a sibship analysis indicated that the association was not confounded by maternal characteristics that remain stable between deliveries.

What Is Known Already: Previous studies indicate that ART singletons with VTS have increased risk of adverse pregnancy outcomes, compared with other ART singletons. The potential contribution of unmeasured maternal background characteristics has been unclear. Read More

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http://dx.doi.org/10.1093/humrep/dex277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850786PMC
November 2017
19 Reads

The Vanishing Twin Syndrome: Two Cases of Extreme Malformations Associated With Vanished Twins.

Pediatr Dev Pathol 2017 Jul-Aug;20(4):348-353. Epub 2017 Jan 25.

2 Division of Anatomic Pathology, Department of Pathology, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.

Two cases of devastating fetal malformations associated with vanished monochorionic twins were identified upon review of pathology files. A 35-year-old G1P0 woman and 36-year-old G3P1 woman were both diagnosed with an intrauterine twin gestation via transvaginal ultrasound at 10 weeks. The spectrum of fetal anomalies ranged from omphalocele, bilateral upper extremity, and unilateral lower extremity hypoplasia, to craniofacial malformation with diaphragmatic hernia. Read More

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http://dx.doi.org/10.1177/1093526616686470DOI Listing
January 2017
17 Reads
0.860 Impact Factor

Oliver Sacks: Our Correspondence About Twins/Twin Research: Vanishing Twins Syndrome; Discordant Sex in MZ Twins; Pregnancy Outcomes in IVF and ICSI Conceived Twins/Print and Media: Superfetated Twins; Twins Discordant for Smoking; Twins in Fashion; Yale University Twin Hockey Players; Conjoined Twin-Visiting Professor.

Authors:
Nancy L Segal

Twin Res Hum Genet 2017 08;20(4):363-369

Department of Psychology,California State University,Fullerton,CA,USA.

The late neurologist and author, Oliver Sacks, published an insightful 1986 review of Marjorie Wallace's book, The Silent Twins, in the New York Times. Taking exception to his assertion about Sir Francis Galton, I wrote a letter to the Times' editor. The letter was unpublished, but it brought a wonderful response from Sacks himself that is reproduced and examined. Read More

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https://www.cambridge.org/core/product/identifier/S183242741
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http://dx.doi.org/10.1017/thg.2017.34DOI Listing
August 2017
4 Reads

Perinatal Risks Associated with Early Vanishing Twin Syndrome following Transfer of Cleavage- or Blastocyst-Stage Embryos.

J Pregnancy 2016 22;2016:1245210. Epub 2016 Dec 22.

The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine, New York, NY, USA.

. To investigate whether the perinatal risks associated with early vanishing twin (VT) syndrome differ between cleavage- or blastocyst-stage embryo transfers (ET) in fresh in vitro fertilization (IVF) cycles. . Read More

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http://dx.doi.org/10.1155/2016/1245210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5212711PMC
May 2017
6 Reads

Obstetric outcome of vanishing twins syndrome: a systematic review and meta-analysis.

Arch Gynecol Obstet 2017 Mar 17;295(3):559-567. Epub 2017 Jan 17.

Center of Reproductive Medicine, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.

Purpose: Due to the high number of multiple embryo transfers into the uterus performed in assisted reproductive technology treatment (ART), the incidences of twin pregnancy and of vanishing twin syndrome (VTS) are correspondingly high. A number of studies have described the obstetric outcomes of the remaining fetus produced after the other twin had vanished compared with a singleton at the start following ART, but the results are mixed and contradictory. We performed a systematic review of the existing studies to explore the actual obstetric outcome of VTS to allow physicians to adequately advise their patients. Read More

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http://dx.doi.org/10.1007/s00404-017-4289-9DOI Listing
March 2017
14 Reads

Early spontaneous multiple fetal pregnancy reduction is associated with adverse perinatal outcomes in in vitro fertilization cycles.

Womens Health (Lond) 2016 07;12(4):420-6

Weill Cornell Medical Center, The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, New York, NY, USA.

The primary objective of this study is to investigate whether early spontaneous multiple fetal pregnancy reduction, also known as vanishing twin syndrome, is associated with adverse perinatal outcomes in fresh in vitro fertilization cycles. This is a retrospective cohort study of women with live singleton births with and without an early vanishing twin after fresh in vitro fertilization. Characteristics compared included incidence of preterm birth, overall birth weight, overall low birth weight, overall very low birth weight, and term low birth weight. Read More

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http://dx.doi.org/10.1177/1745505716658898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373280PMC
July 2016
24 Reads

The Vanishing Twin Syndrome: Two cases of extreme malformations associated with vanished twins.

Pediatr Dev Pathol 2016 Jun 6. Epub 2016 Jun 6.

10 Emory University School of Medicine; Children's Healthcare of Atlanta at Egleston Pathology.

Two cases of devastating fetal malformations associated with vanished monochorionic twins were identified upon review of pathology files. A 35 year-old G1P0 woman and 36 year-old G3P1 woman were both diagnosed with an intrauterine twin gestation via transvaginal ultrasound at 10 weeks. The spectrum of fetal anomalies ranged from omphalocele, bilateral upper extremity and unilateral lower extremity hypoplasia, to craniofacial malformation with diaphragmatic hernia. Read More

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http://dx.doi.org/10.2350/16-01-1763-CR.1DOI Listing
June 2016
10 Reads

Analysis of pregnancy outcomes for survivors of the vanishing twin syndrome after in vitro fertilization and embryo transfer.

Eur J Obstet Gynecol Reprod Biol 2016 Aug 20;203:35-9. Epub 2016 May 20.

Reproductive Medicine, Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201620, China.

Objective: The purpose of this study was to compare pregnancy outcomes of in vitro fertilization (IVF) singletons diagnosed with vanishing twin syndrome with control pregnancies originating as singleton pregnancies and with twin pregnancies.

Study Design: The current research included 206 survivors of a vanished co-twin, 1730 primary singletons and 662 primary twins. The study group was subdivided according to gestational age at the time of vanishing to give groups of early (≤12 weeks, group A) and late (>12 weeks, group B) survivors. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2016.04.014DOI Listing
August 2016
11 Reads

Implementation of non-invasive prenatal testing by semiconductor sequencing in a genetic laboratory.

Prenat Diagn 2016 Aug 1;36(8):699-707. Epub 2016 Jul 1.

Center for Medical Genetics Ghent, Ghent University Hospital, Ghent University, Ghent, Belgium.

Objectives: To implement non-invasive prenatal testing (NIPT) for fetal aneuploidies with semiconductor sequencing in an academic cytogenomic laboratory and to evaluate the first 15-month experience on clinical samples.

Methods: We validated a NIPT protocol for cell-free fetal DNA sequencing from maternal plasma for the detection of trisomy 13, 18 and 21 on a semiconductor sequencing instrument. Fetal DNA fraction calculation for all samples and several quality parameters were implemented in the workflow. Read More

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http://dx.doi.org/10.1002/pd.4841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108441PMC
August 2016
16 Reads

Vanished Twins and Misdiagnosed Sex: A Case Report with Implications in Prenatal Counseling Using Noninvasive Cell-Free DNA Screening.

J Am Board Fam Med 2016 May-Jun;29(3):411-3

From The Department of Family Medicine, Penn State Milton S. Hershey Medical Center, Hershey, PA.

Cell-free DNA testing is a recently introduced method for screening pregnant women for fetal trisomy, which is associated with some common significant genetic diseases, as well as the sex of the fetus. The case described here demonstrates the connection between the ultrasound "vanishing twin" phenomenon and the misdiagnosis of prenatal sex using cell-free DNA testing. Read More

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http://dx.doi.org/10.3122/jabfm.2016.03.150196DOI Listing
November 2017
4 Reads

Two consecutive singleton pregnancies versus one twins pregnancy as preferred outcome of in vitro fertilization for mothers and infants: a retrospective case-control study.

Curr Med Res Opin 2016 28;32(4):687-92. Epub 2016 Jan 28.

a Center of Reproductive Medicine and Surgery, Arcispedale Santa Maria Nuova (ASMN) - Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) , Reggio Emilia , Italy ;

Objective: Many infertile couples request a multiple embryo transfer because they desire more than one child. Based on this consideration, the current study aimed to compare the reproductive and perinatal outcomes of two consecutive singleton pregnancies versus one twin pregnancy in a large cohort of in vitro fertilization (IVF) patients.

Research Design And Methods: Retrospective analysis of data from patients with clinical twin pregnancy after IVF fresh cycles and from patients with two consecutive IVF fresh cycles and clinical singleton pregnancy. Read More

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https://www.tandfonline.com/doi/full/10.1185/03007995.2015.1
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http://dx.doi.org/10.1185/03007995.2015.1136602DOI Listing
December 2016
13 Reads

Extensive Aplasia Cutis Congenita with Associated Vanishing Twin Syndrome.

J Pediatr 2015 Sep;167(3):772.e1

University of Colorado, Children's Hospital Colorado, Aurora, Colorado.

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https://linkinghub.elsevier.com/retrieve/pii/S00223476150067
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http://dx.doi.org/10.1016/j.jpeds.2015.06.041DOI Listing
September 2015
6 Reads

Vanishing twin syndrome: is it associated with adverse perinatal outcome?

Fertil Steril 2015 May 13;103(5):1209-14. Epub 2015 Mar 13.

Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva, Israel.

Objective: To evaluate whether vanishing twin syndrome (VTS) is associated with adverse perinatal outcome.

Design: A retrospective cohort study investigating the impact of VTS on perinatal outcome was conducted. Parturients were classified into three groups: those pregnancies that started with double fetal sacs and spontaneously reduced into one (VTS), those with dichorionic twins, and those with singleton pregnancies. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2015.02.009DOI Listing
May 2015
10 Reads
4 Citations
4.590 Impact Factor

[Obstetric and neonatal outcomes of vanishing twin syndrome].

Nan Fang Yi Ke Da Xue Xue Bao 2014 Oct;34(10):1537-40

Center of Assisted Reproductive Technology, Guangzhou Women and Children Hospital, Guangzhou 510623, China.E-mail:

Objective: To compare the obstetric and neonatal outcomes of singleton pregnancies originating from vanishing twin syndrome with those of singleton pregnancies originating from a single gestation following in vitro fertilization-embryo transfer (IVF-ET).

Methods: This case-control study involved a total of 409 singleton deliveries after IVF-ET/freeze-thawed embryo transfer, including 44 survivors of vanishing twin syndrome (study group) and 365 singletons (control group). The duration of gestation, rate of preterm delivery, neonatal birth weight and proportion of low birth weight were compared between the two groups. Read More

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October 2014
24 Reads

College-age twins: university admission policies / twin research: birth weight and neuromotor performance; transfusion syndrome markers; vanishing twins and fetal sex determination; mz twin discordance for wilson's disease / media: big at birth; planned separation of conjoined twins; x factor twins; Cinema: the identical.

Authors:
Nancy L Segal

Twin Res Hum Genet 2014 Dec 21;17(6):594-8. Epub 2014 Oct 21.

Department of Psychology,California State University,Fullerton,CA,USA.

There is a lack of research findings addressing the unique college admissions issues faced by twins and other multiples. The advantages and disadvantage twins face, as reported by college administrators, twins and families are reviewed. Next, recent research addressing twins' birth weight and neuromotor performance, transfusion syndrome markers, the vanishing twin syndrome and monozygotic (MZ) twin discordance for Wilson's disease is described. Read More

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http://dx.doi.org/10.1017/thg.2014.66DOI Listing
December 2014
8 Reads

Potential of syncytiotrophoblasts isolated from the cervical mucus for early non-invasive prenatal diagnosis: evidence of a vanishing twin.

Clin Chim Acta 2015 Jan 8;438:309-15. Epub 2014 Sep 8.

Department of Anatomy and Developmental Biology, Monash University, Melbourne, Australia; Berry Genomics, Beijing, China. Electronic address:

Background: Non-invasive methods to assess the foetal genome during pregnancy will provide new opportunities to offer pregnant women a more comprehensive genetic diagnosis of their established foetus. The aim of this study was to determine the presence and frequency of foetal cells in transcervical cell (TCC) mucus samples from pregnant women and determine their suitability for early prenatal diagnosis.

Methods: Syncytiotrophoblasts in aspirated TCC mucus samples were identified by immunostaining with the foetal-specific antibody NDOG1. Read More

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http://dx.doi.org/10.1016/j.cca.2014.09.002DOI Listing
January 2015
10 Reads

First and second trimester maternal serum markers in pregnancies with a vanishing twin.

Prenat Diagn 2015 Jan 5;35(1):90-6. Epub 2014 Oct 5.

Genetics Program, North York General Hospital, Toronto, Ontario, Canada.

Objective: The aim of this study was to assess the concentration of the first and second trimester maternal serum markers in pregnancies with a vanishing twin.

Methods: This is a retrospective case-control study of pregnancies screened for Down syndrome in one Ontario center. Singleton pregnancies with ultrasound evidence of a vanishing twin were identified, and each was matched with five normal singleton controls for ethnicity, maternal age, gestational age, and blood sampling date. Read More

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http://doi.wiley.com/10.1002/pd.4492
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http://dx.doi.org/10.1002/pd.4492DOI Listing
January 2015
57 Reads

Confined placental origin of the circulating cell free fetal DNA revealed by a discordant non-invasive prenatal test result in a trisomy 18 pregnancy.

Clin Chim Acta 2014 Jun 22;433:190-3. Epub 2014 Mar 22.

Center for Reproduction and Genetics, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, Jiangsu, China. Electronic address:

Background: Non-invasive prenatal testing (NIPT) by massively parallel sequencing is a useful clinical test for the detection of common fetal aneuploidies. While the accuracy of aneuploidy detection can approach 100%, results discordant with the fetus are occasionally reported. In this study we investigated the basis of a discordant T21 positive and T18 negative NIPT result associated with a T18 fetus confirmed by karyotyping. Read More

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http://dx.doi.org/10.1016/j.cca.2014.03.011DOI Listing
June 2014
11 Reads

Vanishing twin as a potential source of bias in non-invasive fetal sex determination: a case report.

J Obstet Gynaecol Res 2014 Apr 10;40(4):1128-31. Epub 2014 Mar 10.

Institute of Molecular Biomedicine, Comenius University, Bratislava, Slovakia.

Detection of fetal sex based on fetal DNA present in maternal plasma is already in clinical use. Here we present a case of false positivity during the first trimester which may be attributable to a vanishing twin. The presence of Y-chromosome-specific sequences is used as a marker to indicate a male fetus and the absence of a female fetus. Read More

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http://dx.doi.org/10.1111/jog.12314DOI Listing
April 2014
49 Reads

Challenges to free will: transgenerational epigenetic information, unconscious processes, and vanishing twin syndrome.

Rev Neurosci 2014 ;25(1):163-75

Here, we present various research results and thoughts with the intention of challenging notions about free choice. Namely, we describe the concept of transgenerational transmission of epigenetic information and discuss its non-conscious effects on cognitive abilities, behavioral and emotional patterns, and responses with regard to one's life and decisions, and the impact these have on the concept of free will. In addition, we discuss the essential role of unconscious mechanisms in human decision processes. Read More

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http://dx.doi.org/10.1515/revneuro-2013-0036DOI Listing
June 2014
17 Reads

Monozygotic Twinning.

Authors:
Kurt Benirschke

Surg Pathol Clin 2013 Mar 21;6(1):27-32. Epub 2012 Dec 21.

Department of Pathology, UCSD Medical Center, University of California San Diego, 200 West Arbor Drive, San Diego, CA 92103, USA. Electronic address:

This article discusses pathologies found in monozygotic twinning. Detailed information is provided regarding the development during monozygotic twin formation: embryo development, twin-to-twin transfusion syndrome, acardiac twinning, vanishing twins, conjoined twins, and Beckwith-Weidmann syndrome twins. An algorithm describing the approach for identifying pathology in a placenta with multiple pregnancies is presented. Read More

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http://dx.doi.org/10.1016/j.path.2012.11.006DOI Listing
March 2013
13 Reads

First trimester prenatal screening among women pregnant after IVF/ICSI.

Hum Reprod Update 2012 Jul 20;18(4):350-9. Epub 2012 Apr 20.

Department of Obstetrics and Gynecology, Hillerod Hospital, Dyrehavevej 29, 3400 Hillerod, Denmark.

Background: Prenatal screening and diagnosis of chromosomal abnormalities especially Down's syndrome in IVF pregnancies are complicated by higher maternal age, a high multiple pregnancy rate, a high risk of a vanishing twin and an increased risk of chromosomal abnormalities, particularly in pregnancies after ICSI. The aim of the present systematic review was to evaluate the findings of first trimester screening for chromosomal abnormalities in IVF/ICSI singleton and twin pregnancies.

Methods: A systematic MESH-term search in MEDLINE using PubMed and the Cochrane Library was performed until May 2011, with no earlier date limit. Read More

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http://dx.doi.org/10.1093/humupd/dms010DOI Listing
July 2012
6 Reads

Adverse obstetric outcome for the vanishing twin syndrome.

Reprod Biomed Online 2010 Feb 3;20(2):256-60. Epub 2009 Dec 3.

Sarah Racine IVF Unit and the Department of Gynecology, Lis Maternity Hospital, Tel-Aviv Sourasky Medical Centre affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

The aim was to compare obstetric outcomes of IVF singleton pregnancies diagnosed with vanishing twin (VT) syndrome with those pregnancies originating as singleton pregnancies and with twin pregnancies. In this case control study, 57 patients diagnosed with VT syndrome were matched and compared with 171 singleton controls and 171 twin controls. Mean gestational age was 35. Read More

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http://dx.doi.org/10.1016/j.rbmo.2009.11.015DOI Listing
February 2010
5 Reads

Aplasia cutis congenita: an association with vanishing twin syndrome.

Eur J Dermatol 2009 Jul-Aug;19(4):372-4. Epub 2009 May 25.

Division of Neonatology and Neonatal Intensive Care Unit, S.C. Neonatologia e Terapia Intensiva Neonatale, A.O. Ospedale Niguarda "Ca' Granda", P.zza Ospedale Maggiore 3, 20162 Milano, Italy.

Aplasia cutis congenita (ACC) is an inborn skin defect, variably associated with absence of the underlying subcutaneous fat and bone. Frieden IJ proposed a classification system for ACC consisting of 9 groups according to lesion distribution and associated malformations. We report a child resembling ACC group 5, with extensive truncal and limb skin defects and fetus papyraceous, the so-called vanishing twin syndrome. Read More

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http://dx.doi.org/10.1684/ejd.2009.0681DOI Listing
September 2009
12 Reads

The effect of a 'vanishing twin' on biochemical and ultrasound first trimester screening markers for Down's syndrome in pregnancies conceived by assisted reproductive technology.

Hum Reprod 2009 Jan 3;24(1):55-62. Epub 2008 Oct 3.

Department of Fetal Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Background: Previous studies have found that 1 in 10 in vitro fertilization (IVF) singletons originates from a twin gestation. First trimester Down's syndrome screening markers are altered in assisted reproductive techniques (ART) pregnancies compared with spontaneously conceived pregnancies. The presence of a perished embryo may further complicate prenatal screening among women pregnant after ART. Read More

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http://dx.doi.org/10.1093/humrep/den362DOI Listing
January 2009
4 Reads

Psychological vulnerability of singleton children after the 'vanishing' of a co-twin following assisted reproduction.

Twin Res Hum Genet 2008 Feb;11(1):93-8

Department of Obstetrics and Gynecology, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.

We test the hypothesis that parents who conceived twins by assisted reproduction technology (ART), but experienced loss of one twin, have a different parental-child relationship compared with ART parents following a singleton pregnancy. We used the 1994-2005 ART database of the Centre for Infertility of the Arcispedale Santa Maria Nuova in Reggio Emilia, Italy to identify families of 53 singleton births after the 'vanishing' twin syndrome. The controls comprised 106 families who conceived and delivered singletons, matched for gestational age (>or= 28 or= 32 or= 37 weeks), maternal age (< 35, >or= 35 40 years), child's age (1-3, 4-6, and 7-11 years) and child's gender. Read More

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http://dx.doi.org/10.1375/twin.11.1.93DOI Listing
February 2008
10 Reads

Birth weight is lower for survivors of the vanishing twin syndrome: a case-control study.

Fertil Steril 2008 Aug 10;90(2):310-4. Epub 2007 Oct 10.

IVF Unit, Landesfrauen- und Kinderklinik, and Department of Gynecology, Allgemeines Krankenhaus, Linz, Austria.

Objective: To compare the outcome of singleton pregnancies originating from a twin gestation with singleton pregnancies originating from a single gestation.

Design: Case-control study.

Setting: Women's general hospital in Austria. Read More

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http://linkinghub.elsevier.com/retrieve/pii/S001502820701398
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http://dx.doi.org/10.1016/j.fertnstert.2007.06.048DOI Listing
August 2008
6 Reads

Effect of the mode of assisted reproductive technology conception on obstetric outcomes for survivors of the vanishing twin syndrome.

Fertil Steril 2006 Jul 23;86(1):247-9. Epub 2006 May 23.

Department of Obstetrics and Gynecolgy, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.

Survivors of the "vanishing" twin syndrome, which occurred in dichorionic twins only, and singletons that began as singletons, had similar mean gestational duration and birth weights, as well as similar frequencies of maternal and neonatal complications. This similarity persisted when conventional IVF and IVF plus ICSI cases were separately evaluated. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2005.11.073DOI Listing
July 2006
8 Reads

Does a "vanishing twin" affect first-trimester biochemistry in Down syndrome risk assessment?

Am J Obstet Gynecol 2006 Jul 19;195(1):236-9. Epub 2006 Apr 19.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY, USA.

Objective: The purpose of this study was to evaluate the impact of spontaneous reduction in multifetal pregnancy on first-trimester maternal serum biochemistry.

Study Design: We evaluated first-trimester pregnancy associated plasma protein-A (PAPP-A) and free beta-human chorionic gonadotropin levels in singleton euploid pregnancies. Biochemical values in pregnancies with evidence of spontaneous reduction were compared to other singleton pregnancies. Read More

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http://linkinghub.elsevier.com/retrieve/pii/S000293780600078
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http://dx.doi.org/10.1016/j.ajog.2006.01.044DOI Listing
July 2006
6 Reads

[First trimester ultrasound screening for structural and chromosomal anomalies in multiple pregnancy].

Akush Ginekol (Sofiia) 2004 ;43(5):11-8

Aim Of The Study: To assess the feasibility of first trimester ultrasound screening for structural and chromosomal fetal anomalies in multiple gestations.

Methods: An observational prospective follow up study was carried out in 32 cases of multiple pregnancies. Two scans were scheduled in each case--the first, between 6-9 weeks of gestation (w. Read More

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December 2004
4 Reads

A case-control study of vanishing twin as a risk factor for cerebral palsy.

Twin Res 2003 Apr;6(2):83-4

Epidemiology Unit, Gibson Building, Radcliffe Infirmary, Oxford, OX2 6HE, UK.

It has been hypothesized that cerebral palsy of unknown etiology is the result of the death of an unrecognized co-twin--a vanishing twin--in early gestation. We conducted a case-control study of vanishing twin as a risk factor for cerebral palsy of unknown etiology in women who had an obstetric ultrasound during pregnancy. Among mothers of cases, one of 86 had evidence of a vanishing twin on ultrasound, as compared to two of 381 control mothers (odds ratio [OR] 2. Read More

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http://dx.doi.org/10.1375/136905203321536191DOI Listing
April 2003
8 Reads

Pregnancy and birth after assisted reproduction.

Reprod Biomed Online 2002 Jul-Aug;5(1):78-88

Grupo de Reproducción y Genética AGN y Asociados, Camino Santa Teresa No. 1055 Suite 701, Col. Héroes de Padierna, DF 10700, Mexico.

Pregnancy and birth after IVF has attracted much critical attention. Overall, pregnancy rates are about 30-40% with three transferred embryos. Abortion rates are high before 19 weeks of gestation, at 8% of established pregnancies, and ectopic pregnancies are regular occurrences. Read More

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January 2003
4 Reads

Loss in higher multiple pregnancy and multifetal pregnancy reduction.

Authors:
Elizabeth Bryan

Twin Res 2002 Jun;5(3):169-74

Multiple Births Foundation, Queen Charlotte's & Chelsea Hospital, London, UK.

From early pregnancy into childhood, higher multiples have much higher rates of mortality, whether from spontaneous abortion, the 'vanishing twin' syndrome, fetal or infant death. Many parents must cope with the death of one baby whilst the siblings remain critically ill or later become disabled and yet there grief is often underestimated. Little is known about the long term feelings of parents who choose to have a multifetal pregnancy reduction (MFPR). Read More

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June 2002
7 Reads

Is monochorionic twinning a risk factor for focal cortical dysgenesis?

Acta Neurol Scand 2000 Jul;102(1):53-9

Department of Neurology, Trondheim University Hospital, Norway.

Objectives: Various genetic and acquired factors have been proposed as being etiologically important in cortical dysgenesis. It has been suggested that fetal, developmental abnormalities may be induced by transient, circulatory instability in monochorionic twinning due to feto-fetal transfusions. We report the discordant occurrence of a malformation of cortical development in monozygotic, monochorionic twins, and discuss the findings and possible pathogenetic mechanisms. Read More

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July 2000
4 Reads

A hypothesis for the aetiology of spastic cerebral palsy--the vanishing twin.

Dev Med Child Neurol 1997 May;39(5):292-6

Department of Public Health, University of Liverpool, UK.

The aetiology of spastic cerebral palsy (CP), in the majority of cases, is not known but the general consensus is that cerebral impairment occurs prepartum. In monochorionic twin pregnancies, death of one twin late in gestation is recognised as being an important risk factor for the surviving cotwin to have CP. It has been suggested that a significant proportion of singletons with spastic CP may be the result of death of a cotwin in the second half of gestation. Read More

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https://www.researchgate.net/profile/Peter_Pharoah/publicati
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May 1997
8 Reads

The vanishing twin: pathologic confirmation of an ultrasonographic phenomenon.

Obstet Gynecol 1986 Dec;68(6):811-5

Although the phenomenon of the "vanished twin" has been noted repeatedly through the use of ultrasound, no confirmatory histologic evidence has been presented previously. This has raised questions concerning the validity of the vanishing twin syndrome. In the following case, a triplet intrauterine pregnancy was diagnosed ultrasonographically four weeks after in vitro fertilization, but only a single fetus and placenta were delivered at term. Read More

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December 1986
6 Reads
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