30,636 results match your criteria Vagus Nerve


Gut-brain axis and the spread of α-synuclein pathology: vagal highway or dead end?

Mov Disord 2019 Jan 17. Epub 2019 Jan 17.

Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, Toronto, Canada.

Spread of α-synuclein pathology from the peripheral to central nervous system may be an important etiological factor in Parkinson's disease, although there are some unanswered questions about its correlation with neuronal loss. Experimental evidence has highlighted the gastrointestinal tract as a potential starting point for aggregated α-synuclein, with the vagus nerve acting as a "highway" by which pathology may be transmitted to the lower brain stem. This review begins by highlighting the key studies demonstrating that α-synuclein pathology has the ability to spread from certain sites in the gastrointestinal tract to the brain (and vice versa). Read More

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http://dx.doi.org/10.1002/mds.27556DOI Listing
January 2019
1 Read

Response by Kimberley and Dawson Regarding Article, "Vagus Nerve Stimulation Paired With Upper Limb Rehabilitation After Chronic Stroke: A Blinded Randomized Pilot Study".

Stroke 2019 Jan 17:STROKEAHA118024405. Epub 2019 Jan 17.

Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, Queen Elizabeth University Hospital, University of Glasgow, United Kingdom.

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http://dx.doi.org/10.1161/STROKEAHA.118.024405DOI Listing
January 2019

Vagus nerve stimulation for pediatric patients with intractable epilepsy between 3 and 6 years of age: study protocol for a double-blind, randomized control trial.

Trials 2019 Jan 14;20(1):44. Epub 2019 Jan 14.

Division of Pediatric Neurology, Pediatrics Department, Peking University First Hospital, No.1 Xi'an Men Street, West District, Beijing, 100034, China.

Background: Recent clinical observations have reported the potential benefit of vagus nerve stimulation (VNS) as an adjunctive therapy for pediatric epilepsy. Preliminary evidence suggests that VNS treatment is effective for seizure reduction and mental development in young participants between 3 and 6 years of age who suffer from intractable epilepsy. However, robust clinical evidence for quantifying the difference of the efficacy and safety of VNS treatment in this specific patient population has yet to be reported. Read More

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http://dx.doi.org/10.1186/s13063-018-3087-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332620PMC
January 2019

Natural Killer Cells may Exert Antidepressant-like Effects in Mice by Controlling the Release of Inflammatory Factors.

Neuroscience 2019 Jan 11. Epub 2019 Jan 11.

The Engineering Research Center of Peptide Drug Discovery and Development, China Pharmaceutical University, Nanjing, Jiangsu 210009, PR China; State Key Laboratory of National Medicines, Ministry of Education, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address:

Depression or stress is reportedly related to the overflow of inflammatory factors in the body and T cells were reported to play important roles in balancing the release of inflammatory factors through vagus nerve circuit. However, few works have been conducted to find if natural killer (NK) cells can also exert the similar function in the reported vagus nerve circuit as T cells and if there was any relationship between depression and this function. In the present study, the behavioral tests on BALB/c mice indicated that the depressant-like symptoms could be improved and simultaneously the concentrations of inflammatory factors in peripheral blood could be reduced significantly by adoptively transferring NK cells into stressed BALB/c mice. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03064522193001
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http://dx.doi.org/10.1016/j.neuroscience.2019.01.002DOI Listing
January 2019
1 Read

Neuromodulatory treatments for post-traumatic stress disorder (PTSD).

Prog Neuropsychopharmacol Biol Psychiatry 2019 Jan 11;92:148-160. Epub 2019 Jan 11.

Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, USA; VA RR&D Center for Neurorestoration and Neurotechnology, Providence VA Medical Center, Providence, RI, USA.

Electroconvulsive therapy has been used successfully in some individuals with posttraumatic stress disorder (PTSD) whose symptoms have not improved with other treatments. But there are only a few reports. Meanwhile, an array of new neuromodulation strategies, including repetitive transcranial magnetic stimulation, transcranial direct current stimulation, vagus nerve stimulation, trigeminal nerve stimulation, and deep brain stimulation have been developed and applied experimentally in the treatment of other psychiatric disorders. Read More

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http://dx.doi.org/10.1016/j.pnpbp.2019.01.004DOI Listing
January 2019

Differential age-, gender- and side-dependency of vagus, spinal accessory and phrenic nerve calibers detected with precise ultrasonography measures.

Muscle Nerve 2019 Jan 13. Epub 2019 Jan 13.

Department of Neurology, University of Rostock, Rostock, Germany.

Introduction: The standard ultrasonographic measurement tools (trace, ellipse) of cross-sectional areas (CSA) of very small nerves typically yield rough measures in full square millimeters.

Methods: In 70 volunteers, the elliptically shaped CSAs of mid-cervical vagus, accessory and phrenic nerves were estimated with three methods: two on-board tools (area tracing, ellipse fitting) and an off-line calculation of the CSA after on-board measuring of its long-axis and short-axis diameters both displayed with 1-2 digits following the decimal point.

Results: CSA measures of all mid-cervical nerves obtained with the precise approach were smaller than the two standard measures (each P<0. Read More

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http://dx.doi.org/10.1002/mus.26412DOI Listing
January 2019

Body thermal responses and the vagus nerve.

Authors:
Rui B Chang

Neurosci Lett 2019 Jan 8. Epub 2019 Jan 8.

Department of Neuroscience, Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, CT, 06520, United States. Electronic address:

While thermosensation from external environment has been extensively studied, physiological responses to temperature changes inside the body and the underlying regulatory mechanisms are less understood. As a critical link between body and brain that relays visceral organ information and regulates numerous physiological functions, the vagus nerve has been proposed to mediate diverse visceral thermal reflexes and indirectly regulate body temperature. However, the precise role of the vagus nerve in body thermal responses or visceral organ-related thermoregulation is still under debate due to extensive contradictory results. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.01.013DOI Listing
January 2019
2 Reads

A unifying conceptual framework of factors associated to cardiac vagal control.

Heliyon 2018 Dec 8;4(12):e01002. Epub 2018 Dec 8.

University of Bielefeld, Germany.

Cardiac vagal control (CVC) reflects the activity of the vagus nerve regulating cardiac functioning. CVC can be inferred via heart rate variability measurement, and it has been positively associated to a broad range of cognitive, emotional, social, and health outcomes. It could then be considered as an indicator for effective self-regulation, and given this role, one should understand the factors increasing and decreasing CVC. Read More

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http://dx.doi.org/10.1016/j.heliyon.2018.e01002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6313821PMC
December 2018

Correction to: Practical and clinical utility of non-invasive vagus nerve stimulation (nVNS) for the acute treatment of migraine: a post hoc analysis of the randomized, sham-controlled, double-blind PRESTO trial.

J Headache Pain 2019 Jan 7;20(1). Epub 2019 Jan 7.

Headache and Pain Unit, IRCCS San Raffaele Pisana, Rome, Italy.

Following publication of the original article [1], the authors notified us that a part of the Figure 3 legend was omitted during proofing stage. Read More

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http://dx.doi.org/10.1186/s10194-018-0948-xDOI Listing
January 2019

Practical Perspectives in the Treatment of Nausea and Vomiting.

J Clin Gastroenterol 2019 Jan 4. Epub 2019 Jan 4.

Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School Boston, MA.

Nausea and vomiting result from complex interactions between afferent and efferent pathways of the gastrointestinal tract, central nervous system, and autonomic nervous system. Afferent pathways from the vagus nerve, vestibular system, and chemoreceptor trigger zone project to nucleus tractus solitarius, which in turn relays signals to the central pattern generator to initiate multiple downstream pathways resulting in symptoms of nausea and vomiting. There is increasing evidence that the central pathway of chronic nausea is different from that of acute nausea and vomiting-and closely resembles that of neuropathic pain. Read More

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http://Insights.ovid.com/crossref?an=00004836-900000000-9778
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http://dx.doi.org/10.1097/MCG.0000000000001164DOI Listing
January 2019
6 Reads

AKI and the Neuroimmune Axis.

Semin Nephrol 2019 Jan;39(1):85-95

Division of Nephrology and Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, VA. Electronic address:

Neuroimmune interaction is an emerging concept, wherein the nervous system modulates the immune system and vice versa. This concept is gaining attention as a novel therapeutic target in various inflammatory diseases including acute kidney injury (AKI). Vagus nerve stimulation or treatment with pulsed ultrasound activates the cholinergic anti-inflammatory pathway to prevent AKI in mice. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02709295183015
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http://dx.doi.org/10.1016/j.semnephrol.2018.10.008DOI Listing
January 2019
4 Reads

Routine Intraoperative Neuromonitoring of the Recurrent Laryngeal Nerve to Facilitate Complete Resection and Ensure Safety in Thyroid Cancer Surgery.

Am Surg 2018 Dec;84(12):1882-1888

Routine use of intraoperative neuromonitoring (IONM) in thyroid cancer surgery is controversial. We aimed to investigate whether it improves the completeness of thyroidectomy and ensures safety. This retrospective study included 380 thyroid cancer patients who underwent thyroidectomy, by one surgeon, between July 2006 and November 2015. Read More

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December 2018

Iso-α-acids, the bitter components of beer, improve hippocampus-dependent memory through vagus nerve activation.

FASEB J 2019 Jan 2:fj201801868RR. Epub 2019 Jan 2.

Division of Pharmacology, Kobe University Graduate School of Medicine, Kobe-shi, Japan; and.

Iso-α-acids (IAAs) are hop-derived bitter acids of beer. Epidemiologic studies suggest that moderate alcohol consumption is beneficial for cognitive function, but they do not show the ingredients in alcoholic beverages. Previously, we reported that long-term consumption of IAAs prevents inflammation and Alzheimer pathologies in mice, but their effects on cognitive function have not been evaluated. Read More

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http://dx.doi.org/10.1096/fj.201801868RRDOI Listing
January 2019
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Transcranial motor-evoked potentials of laryngeal muscles for intraoperative neuromonitoring of the vagus nerve during thyroid surgery.

J Anesth 2019 Jan 2. Epub 2019 Jan 2.

Department of Anesthesiology and Resuscitology, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan.

Purpose: The aim of this study was to elucidate normative features of vagal motor-evoked potentials (MEPs) induced by transcranial electrical stimulation (TES) and to determine the influence of functional decline of the recurrent laryngeal nerve (RLN) on vagal MEPs during thyroid surgery.

Methods: A total of 54 patients undergoing elective thyroid surgery under general anesthesia were enrolled in this study. Vagal MEPs induced by TES were measured from the vocal cord using one of two types of electrodes (wire type or wide and flat type) mounted on an endotracheal tube. Read More

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http://dx.doi.org/10.1007/s00540-018-2601-xDOI Listing
January 2019

Cranial nerve injuries in Le Fort I osteotomy: a systematic review.

Int J Oral Maxillofac Surg 2018 Dec 28. Epub 2018 Dec 28.

Department of Morphology, Post-Graduate Program in Morphofunctional Sciences, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil; Department of Clinical Dentistry, Post-Graduate Program in Dentistry, Faculty of Pharmacy, Dentistry and Nursing, Federal University of Ceará, Fortaleza, Ceará, Brazil. Electronic address:

The aim of this systematic review was to describe the anatomical and surgical factors related to cranial nerve injuries in Le Fort I osteotomy. The protocol of this systematic review was registered in the International Prospective Register of Systematic Reviews (PROSPERO). Two independent reviewers performed an unrestricted electronic database search in the MEDLINE/PubMed, LILACS, Scopus, Web of Science, and Cochrane databases up to and including August 2018. Read More

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http://dx.doi.org/10.1016/j.ijom.2018.11.012DOI Listing
December 2018

Lead failure after vagus nerve stimulation implantation: X-ray examination and revision surgery.

World Neurosurg 2018 Dec 26. Epub 2018 Dec 26.

Department of Functional Neurosurgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Objective: This study aimed to assess the most common types of lead failures, identify causes and discuss potential procedures for revision surgery following vagus nerve stimulator implantation in epilepsy patients.

Methods: In a retrospective study over an 8-year period, 13 patients underwent revision surgery due to lead failure. Lead failure was classified as either lead intrinsic damage or lead pin disengagement from the generator header. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750183289
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http://dx.doi.org/10.1016/j.wneu.2018.12.070DOI Listing
December 2018
6 Reads

Innervation of the human spleen: A complete hilum-embedding approach.

Brain Behav Immun 2018 Dec 26. Epub 2018 Dec 26.

Department of Anatomy & Embryology, Faculty of Health, Medicine and Life Sciences, Maastricht University, the Netherlands.

Introduction: The spleen is hypothesized to play a role in the autonomic nervous system (ANS)-mediated control of host defence, but the neuroanatomical evidence for this assumption rests on a sparse number of studies, which mutually disagree with respect to the existence of cholinergic or vagal innervation.

Methods: We conducted an immuno- and enzyme-histochemical study of the innervation of the human spleen using a complete hilum-embedding approach to ensure that only nerves that entered or left the spleen were studied, and that all splenic nerves were included in the sampled area. Furthermore, a complete embedded spleen was serially sectioned to prepare a 3D reconstruction of the hilar nerve plexus. Read More

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http://dx.doi.org/10.1016/j.bbi.2018.12.009DOI Listing
December 2018

Transcutaneous auricular vagus nerve stimulation in treating major depressive disorder: A systematic review and meta-analysis.

Medicine (Baltimore) 2018 Dec;97(52):e13845

Medical College of Acu-Moxi and Rehabilitation.

Background: Transcutaneous auricular vagus nerve stimulation (taVNS), as a noninvasive intervention, has beneficial effects on major depressive disorder based on clinical observations. However, the potential benefits and clinical role of taVNS in the treatment of major depressive disorder are still uncertain and have not been systematically evaluated. Therefore, we performed a systematic review and meta-analysis to evaluate the effectiveness and safety of taVNS in treating major depressive disorder. Read More

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http://dx.doi.org/10.1097/MD.0000000000013845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314717PMC
December 2018

The neuromodulatory and hormonal effects of transcutaneous vagus nerve stimulation as evidenced by salivary alpha amylase, salivary cortisol, pupil diameter, and the P3 event-related potential.

Brain Stimul 2018 Dec 14. Epub 2018 Dec 14.

Institute of Psychology, Leiden University, Leiden, 2333, AK, Netherlands; Leiden Institute for Brain and Cognition, Leiden University, Leiden, 2300, RC, Netherlands.

Background: Transcutaneous vagus nerve stimulation (tVNS) is a new, non-invasive technique being investigated as an intervention for a variety of clinical disorders, including epilepsy and depression. It is thought to exert its therapeutic effect by increasing central norepinephrine (NE) activity, but the evidence supporting this notion is limited.

Objective: In order to test for an impact of tVNS on psychophysiological and hormonal indices of noradrenergic function, we applied tVNS in concert with assessment of salivary alpha amylase (SAA) and cortisol, pupil size, and electroencephalograph (EEG) recordings. Read More

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http://dx.doi.org/10.1016/j.brs.2018.12.224DOI Listing
December 2018

Tumor multifocality with vagus nerve involvement as a phenotypic marker of SDHD mutation in patients with head and neck paragangliomas: A F-FDOPA PET/CT study.

Head Neck 2018 Dec 24. Epub 2018 Dec 24.

Department of Nuclear Medicine, La Timone University Hospital, Aix-Marseille University, Marseille, France.

Background: F-FDOPA PET/CT was proved to be a highly sensitive imaging method for detecting head and neck paraganglioma (HNPGL). The primary aim of the study was to evaluate the relationship between tumor characteristics and the SDHx-mutational status in a large series of patients with HNPGL evaluated by F-FDOPA PET/CT.

Methods: A total of 104 patients with HNPGL (65 sporadic/39 SDHx-mutated) were included. Read More

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http://dx.doi.org/10.1002/hed.25604DOI Listing
December 2018

Transcutaneous vagus nerve stimulation does not affect attention to fearful faces in high worriers.

Behav Res Ther 2019 Feb 19;113:25-31. Epub 2018 Dec 19.

Leiden University, Clinical Psychology Unit, Wassenaarseweg 52, 2300, RB, Leiden, the Netherlands.

People suffering from chronic worries pay excessive attention to emotional information. In this study we examined whether a reduced ability to inhibit attention from fearful faces (i.e. Read More

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http://dx.doi.org/10.1016/j.brat.2018.12.009DOI Listing
February 2019

Toward Improved Control of Inflammatory Bowel Disease.

Scand J Immunol 2018 Dec 23:e12745. Epub 2018 Dec 23.

Center for Bioelectronic Medicine, Department of Medicine, Center for Molecular Medicine, Solna, Karolinska Institutet, Karolinska University HospitalStockholm, Sweden.

Inflammatory bowel disease (IBD), is characterized by activation of both the innate and adaptive immune system in genetically susceptible individuals, resulting in chronic intestinal inflammation. The triggers that initiate and perpetuate this continuous inflammation are the subject of much speculation and research, although the central role of the intestinal microbiota is recognized and is even a target for treatment in some circumstances. The mainstay of modern IBD-treatment is suppression of the immune response towards as yet unspecified antigens, and conventional therapy includes corticosteroids, 5-aminosalicylic acid (5-ASA), thiopurines and methotrexate. Read More

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http://dx.doi.org/10.1111/sji.12745DOI Listing
December 2018

Hepatic c-Jun regulates glucose metabolism via FGF21 and modulates body temperature through the neural signals.

Mol Metab 2018 Dec 12. Epub 2018 Dec 12.

CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, China. Electronic address:

Objective: c-Jun, a prominent member of the activator protein 1 (AP-1) family, is involved in various physiology processes such as cell death and survival. However, a role of hepatic c-Jun in the whole-body metabolism is poorly understood.

Methods: We generated liver-specific c-Jun knock-out (c-jun) mice to investigate the effect of hepatic c-Jun on the whole-body physiology, particularly in blood glucose and body temperature. Read More

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http://dx.doi.org/10.1016/j.molmet.2018.12.003DOI Listing
December 2018

Precious cargo: Modulation of the mesenteric lymph exosome payload after hemorrhagic shock.

J Trauma Acute Care Surg 2019 Jan;86(1):52-61

From the Division of Trauma, Surgical Critical Care, Burns and Acute Care Surgery, Department of Surgery, University of California San Diego Health, San Diego, California (E.C.W., T.W.C., A.B., B.P.E., T.W.C.); and Riverside University Health System Medical Center, Loma Linda University School of Medicine, Moreno Valley, California (R.C.).

Background: Trauma/hemorrhagic shock (T/HS) causes a release of proinflammatory mediators into the mesenteric lymph (ML) that may trigger a systemic inflammatory response and subsequent organ failure. Recently, we showed that exosomes in postshock ML are biologically active mediators of this inflammation. Because the specific inflammatory mediators in postshock ML exosomes have yet to be characterized, we hypothesized that T/HS would lead to a distinct ML proinflammatory exosome phenotype that could be identified by proteomic analysis. Read More

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http://dx.doi.org/10.1097/TA.0000000000002093DOI Listing
January 2019
2 Reads

Novel mediators and mechanisms in the resolution of infectious inflammation: evidence for vagus regulation.

J Intern Med 2018 Dec 19. Epub 2018 Dec 19.

Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Excessive chronic inflammation is linked to many diseases and considered a stress factor in humans (Robbins Pathologic Basis of Disease. Philadelphia: W.B. Read More

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http://dx.doi.org/10.1111/joim.12871DOI Listing
December 2018
1 Read

Brain Glucose Metabolism: Integration of Energetics with Function.

Authors:
Gerald A Dienel

Physiol Rev 2019 01;99(1):949-1045

Department of Neurology, University of Arkansas for Medical Sciences , Little Rock, Arkansas ; and Department of Cell Biology and Physiology, University of New Mexico , Albuquerque, New Mexico.

Glucose is the long-established, obligatory fuel for brain that fulfills many critical functions, including ATP production, oxidative stress management, and synthesis of neurotransmitters, neuromodulators, and structural components. Neuronal glucose oxidation exceeds that in astrocytes, but both rates increase in direct proportion to excitatory neurotransmission; signaling and metabolism are closely coupled at the local level. Exact details of neuron-astrocyte glutamate-glutamine cycling remain to be established, and the specific roles of glucose and lactate in the cellular energetics of these processes are debated. Read More

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http://dx.doi.org/10.1152/physrev.00062.2017DOI Listing
January 2019

Clinically indicated electrical stimulation strategies to treat patients with medically refractory epilepsy.

Epilepsia Open 2018 Dec 16;3(Suppl Suppl 2):198-209. Epub 2018 Nov 16.

Department of Neurological Surgery University of California Davis California, U.S.A.

Focal epilepsies represent approximately half of all diagnoses, and more than one-third of these patients are refractory to pharmacologic treatment. Although resection can result in seizure freedom, many patients do not meet surgical criteria, as seizures may be multifocal in origin or have a focus in an eloquent region of the brain. For these individuals, several U. Read More

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http://dx.doi.org/10.1002/epi4.12276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293066PMC
December 2018

Under-reporting of nocturnal seizures using video-based home monitoring: a case study on the evaluation of the effect of vagal nerve stimulation.

Epileptic Disord 2018 Dec;20(6):535-540

Tampere University, Faculty of Medicine and Health Technology, Tampere, Department of Neurology, Tampere University Hospital, Tampere, Finland.

A challenge in treating epilepsy is the accurate documentation of seizure frequency, which is needed in order to assess the benefits of ongoing treatment. We present a 17-year-old girl who underwent video-based monitoring in order to establish an accurate seizure count before and after the implantation of a vagus nerve stimulator to treat refractory epilepsy. The results show a reduction in disabling seizure types after vagus nerve stimulator implantation and highlight the inconsistencies between the reported and actual seizure count in this patient. Read More

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http://dx.doi.org/10.1684/epd.2018.1018DOI Listing
December 2018
1 Read
0.899 Impact Factor

Correction to: Consistent effects of non-invasive vagus nerve stimulation (nVNS) for the acute treatment of migraine: additional findings from the randomized, sham-controlled, double-blind PRESTO trial.

J Headache Pain 2018 Dec 18;19(1):120. Epub 2018 Dec 18.

Neurophysiology and Pain Unit, University of Bari Aldo Moro, Bari, Italy.

Following publication of the original article [1], the authors notified us o that the Table 1 citation within the legend was not presented as initially requested. Read More

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https://thejournalofheadacheandpain.biomedcentral.com/articl
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http://dx.doi.org/10.1186/s10194-018-0949-9DOI Listing
December 2018
4 Reads

Autonomic Neuromodulation Acutely Ameliorates Left Ventricular Strain in Humans.

J Cardiovasc Transl Res 2018 Dec 17. Epub 2018 Dec 17.

University of Oklahoma Health Sciences Center, 800 Stanton L Young Blvd Suite, Oklahoma City, OK, 5400, USA.

Low-level transcutaneous vagus nerve stimulation at the tragus (LLTS) is anti-adrenergic. We aimed to evaluate the acute effects of LLTS on left ventricular (LV) function and autonomic tone. Patients with diastolic dysfunction and preserved LV ejection fraction were enrolled in a prospective, randomized, double-blind, 2 × 2 cross-over study. Read More

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http://link.springer.com/10.1007/s12265-018-9853-6
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http://dx.doi.org/10.1007/s12265-018-9853-6DOI Listing
December 2018
1 Read

Effective weight control via an implanted self-powered vagus nerve stimulation device.

Nat Commun 2018 12 17;9(1):5349. Epub 2018 Dec 17.

Department of Materials Science and Engineering, University of Wisconsin-Madison, Madison, WI, 53706, USA.

In vivo vagus nerve stimulation holds great promise in regulating food intake for obesity treatment. Here we present an implanted vagus nerve stimulation system that is battery-free and spontaneously responsive to stomach movement. The vagus nerve stimulation system comprises a flexible and biocompatible nanogenerator that is attached on the surface of stomach. Read More

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http://www.nature.com/articles/s41467-018-07764-z
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http://dx.doi.org/10.1038/s41467-018-07764-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297229PMC
December 2018
5 Reads
10.742 Impact Factor

Neurostimulation for depression in epilepsy.

Epilepsy Behav 2018 Nov 4;88S:25-32. Epub 2018 Jul 4.

Beth Israel Deaconess Medical Center, Massachusetts General Hospital, CIMIT- 125 Nashua Street, Suite 324, Boston, MA 02114, United States. Electronic address:

Epilepsy is often associated with comorbid psychiatric illnesses that can significantly impact its long-term course. The most frequent of these psychiatric comorbidities is major depressive disorder, which affects an estimated 40% of patients with epilepsy. Many patients are underdiagnosed or undertreated, yet managing their mood symptoms is critical to improving their outcomes. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.06.007DOI Listing
November 2018

Magnetoencephalographic Source Localization of the Eye Area of the Motor Homunculus.

Can J Neurol Sci 2018 Dec 17:1-7. Epub 2018 Dec 17.

1Division of Neurology,Krembil Brain Institute,University Health Network, Toronto Western Hospital,University of Toronto,Toronto, Ontario,Canada.

A patient with intractable epilepsy, previous right frontal resection, and active vagus nerve stimulation (VNS) developed new onset quasi-continuous twitching around the left eye. Electroencephalography showed no correlate to the orbicularis oculi twitches apart from myographic potentials at the left supraorbital and anterior frontal electrodes. Magnetoencephalography was performed using spatiotemporal signal space separation to suppress magnetic artifacts associated with the VNS apparatus. Read More

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http://dx.doi.org/10.1017/cjn.2018.373DOI Listing
December 2018

Insular Resting State Functional Connectivity is Associated with Gut Microbiota Diversity.

Eur J Neurosci 2018 Dec 16. Epub 2018 Dec 16.

Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, 77030, USA.

The gut microbiota has recently gained attention as a possible modulator of brain activity. A number of reports suggest that the microbiota may be associated with neuropsychiatric conditions such as major depressive disorder, autism, and anxiety. The gut microbiota is thought to influence the brain via vagus nerve signaling, among other possible mechanisms. Read More

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http://dx.doi.org/10.1111/ejn.14305DOI Listing
December 2018
7 Reads

Pharmacologically evoked apnoeas. Receptors and nervous pathways involved.

Life Sci 2019 Jan 13;217:237-242. Epub 2018 Dec 13.

Department of Respiration Physiology, Mossakowski Medical Research Centre Polish Academy of Sciences, A. Pawińskiego 5, 02-106 Warsaw, Poland. Electronic address:

This review analyses the knowledge about the incidence of transient apnoeic spells, induced by substances which activate vagal chemically sensitive afferents. It considers the specificity and expression of appropriate receptors, and relevant research on pontomedullary circuits contributing to a cessation of respiration. Insight is gained into an excitatory drive of 5-HT serotonin receptors in overcoming opioid-induced respiratory inhibition. Read More

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http://dx.doi.org/10.1016/j.lfs.2018.12.021DOI Listing
January 2019

Vagus nerve stimulation reduces ventricular arrhythmias and increases ventricular electrical stability.

Pacing Clin Electrophysiol 2018 Dec 15. Epub 2018 Dec 15.

Xinjiang Key Laboratory of Medical Animal Model Research, Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

Background: Transcutaneous stimulation of the auricular branch of the vagus nerve (AB-VNS) is a potentially noninvasive, inexpensive, and safe approach for vagus nerve stimulation that suppresses the induction and duration of atrial fibrillation and reduces sympathetic nerve outflow in healthy humans. Researchers have not determined whether AB-VNS affects ventricular arrhythmias.

Objective: To evaluate the antiarrhythmic effects of noninvasive AB-VNS on ventricular arrhythmias induced by myocardial infarction (MI). Read More

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http://dx.doi.org/10.1111/pace.13585DOI Listing
December 2018
11 Reads

Autostimulation in Vagus Nerve Stimulator Treatment: Modulating Neuromodulation.

Neuromodulation 2018 Dec 14. Epub 2018 Dec 14.

Department of Neurosciences and Rehabilitation, Tampere University Hospital, Tampere, Finland.

Objectives: Until now, the vagus nerve stimulation (VNS) treatment in epilepsy has consisted of two different modes: normal and magnet stimulation. A new vagus nerve stimulator model (106 AspireSR®, LivaNova, Houston, TX, USA) also allows automatic stimulation (AutoStim). The purpose of this study is to examine the effect of autostimulation on seizure frequencies together with energy consumption. Read More

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http://dx.doi.org/10.1111/ner.12897DOI Listing
December 2018

A systematic review of deep brain stimulation for the treatment of drug-resistant epilepsy in childhood.

J Neurosurg Pediatr 2018 Nov 1:1-11. Epub 2018 Nov 1.

1Division of Neurosurgery, Department of Surgery, University of Toronto.

OBJECTIVEDrug-resistant epilepsy (DRE) presents a therapeutic challenge in children, necessitating the consideration of multiple treatment options. Although deep brain stimulation (DBS) has been studied in adults with DRE, little evidence is available to guide clinicians regarding the application of this potentially valuable tool in children. Here, the authors present the first systematic review aimed at understanding the safety and efficacy of DBS for DRE in pediatric populations, emphasizing patient selection, device placement and programming, and seizure outcomes. Read More

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http://dx.doi.org/10.3171/2018.9.PEDS18417DOI Listing
November 2018

Cost-effectiveness of noninvasive vagus nerve stimulation for acute treatment of episodic migraine and role in treatment sequence strategies.

Am J Manag Care 2018 Dec;24(24 Suppl):S527-S533

electroCore, Inc, Basking Ridge, NJ. Email:

Migraine affects 15% of the population in the United States and is associated with comorbidities, with an estimated economic burden of $78 billion annually. GammaCore is used adjunctively with current standard of care and abortive medications and has shown to be superior in acute treatment of episodic migraine compared to sham. However, the economic impact has not been characterized for this indication. Read More

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December 2018
2.264 Impact Factor

Noninvasive vagus nerve stimulation in a primary care setting: effects on quality of life and utilization measures in multimorbidity patients with or without primary headache.

Am J Manag Care 2018 Dec;24(24 Suppl):S517-S526

electroCore, Inc, Basking Ridge, NJ. Email:

A patient audit was conducted in the UK to evaluate the impact of gammaCore use in multimorbidity patients on quality of life and healthcare resources utilization measures. A total of 233 patients were enrolled and their data was examined over a 1-year period after their gammaCore prescription. Of these patients, 132 (56%) had primary headache disorders while 101 (44%) were patients without a headache disorder (nonheadache patients). Read More

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December 2018
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2.264 Impact Factor

Review of evidence on noninvasive vagus nerve stimulation for treatment of migraine: efficacy, safety, and implications.

Am J Manag Care 2018 Dec;24(24 Suppl):S507-S516

electroCore, Inc, Basking Ridge, NJ. Email:

GammaCore was cleared by the FDA for the acute treatment of episodic migraine and episodic cluster headache and has 5 Conformité Européenne marks. Data indicate that gammaCore treatment is both safe and effective as an acute treatment for migraine. Current reimbursement policies need to be updated based on the growing body of evidence to reflect the established status of gammaCore that is no longer experimental. Read More

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December 2018
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2.264 Impact Factor

Adenylyl Cyclase 6 Mediates Inhibition of TNF in the Inflammatory Reflex.

Front Immunol 2018 27;9:2648. Epub 2018 Nov 27.

Department of Medicine, Center for Bioelectronic Medicine, Center for Molecular Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Macrophage cytokine production is regulated by neural signals, for example in the inflammatory reflex. Signals in the vagus and splenic nerves are relayed by choline acetyltransferase T cells that release acetylcholine, the cognate ligand for alpha7 nicotinic acetylcholine subunit-containing receptors (α7nAChR), and suppress TNF release in macrophages. Here, we observed that electrical vagus nerve stimulation with a duration of 0. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02648
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http://dx.doi.org/10.3389/fimmu.2018.02648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277584PMC
November 2018
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Microbiota modulation by eating patterns and diet composition: impact on food intake.

Am J Physiol Regul Integr Comp Physiol 2018 Dec 19;315(6):R1254-R1260. Epub 2018 Sep 19.

Foods and Nutrition, University of Georgia , Athens, Georgia.

There is accumulating evidence that the gut microbiota and its composition dynamics play a crucial role in regulating the host physiological functions and behavior. Diet composition is the primary modulator of bacterial richness and abundance in the gastrointestinal (GI) tract. Macronutrient (fat, sugar, and protein) and fiber contents are especially important in determining microbiota composition and its effect on health outcomes and behavior. Read More

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https://www.physiology.org/doi/10.1152/ajpregu.00037.2018
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http://dx.doi.org/10.1152/ajpregu.00037.2018DOI Listing
December 2018
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Opportunities and challenges for developing closed-loop bioelectronic medicines.

Neural Regen Res 2019 Jan;14(1):46-50

Medical Devices and Neuromodulation, Battelle Memorial Institute, Columbus, OH, USA.

The peripheral nervous system plays a major role in the maintenance of our physiology. Several peripheral nerves intimately regulate the state of the brain, spinal cord, and visceral systems. A new class of therapeutics, called bioelectronic medicines, are being developed to precisely regulate physiology and treat dysfunction using peripheral nerve stimulation. Read More

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http://dx.doi.org/10.4103/1673-5374.243697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262994PMC
January 2019

Tropisetron inhibits sepsis by repressing hyper-inflammation and regulating the cardiac action potential in rat models.

Biomed Pharmacother 2019 Feb 4;110:380-388. Epub 2018 Dec 4.

Department of Cardiology, the Six Affiliated Hospital of Guangzhou Medical University/ Qingyuan People's Hospital, Qingyuan 511500, China.

Objective: The objective of the present investigation was to explore the possible effect of the 5-HT3 receptor antagonist tropisetron on the expression levels of the inflammatory factors interleukin 6 (IL-6), creatine kinase isoenzyme (CK-MB), soluble growth stimulating gene 2 protein (sST2) and immunoglobulin E (IgE), as well as the cardiac action potential in septic rats.

Methods: The cecal ligation and perforation (CLP) method was utilized to construct abdominal infarction in rats. A total of 68 male adult Sprague Dawley rats were used, including 40 for assessing survival and 28 for detecting the expression levels of IL-6 and IgE, myocardial injury, cardiac dysfunction and the cardiac action potential. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.11.142DOI Listing
February 2019

The effect of transcutaneous auricular vagus nerve stimulation on treatment-resistant depression monitored by resting-state fMRI and MRS: The first case report.

Brain Stimul 2018 Nov 27. Epub 2018 Nov 27.

Department of Radiology, Guang' anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2018.11.013DOI Listing
November 2018
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Translational Study on Recurrent Laryngeal Nerve Temperature Susceptibility.

J Surg Res 2019 Feb 27;234:7-12. Epub 2018 Sep 27.

Division for Endocrine Surgery, Department of Human Pathology in Adulthood and Childhood "G. Barresi," University Hospital G. Martino, University of Messina, Messina, Italy.

Background: Recurrent laryngeal nerve (RLN) injury is the most common and serious complication after thyroid surgery. However, little is known about the temperature threshold leading to RLN injury. In this study, we investigated threshold temperatures that cause RLN injury during thyroid surgery using continuous intraoperative neuromonitoring in swine models. Read More

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http://dx.doi.org/10.1016/j.jss.2018.08.041DOI Listing
February 2019

Neuromodulation - Science and Practice in Epilepsy: Vagus Nerve Stimulation, Thalamic Deep Brain Stimulation, and Responsive NeuroStimulation.

Expert Rev Neurother 2018 Dec 11:1-13. Epub 2018 Dec 11.

a Department of Neurology and Neurological Sciences , Stanford University School of Medicine , Stanford , CA , USA.

Introduction: Neuromodulation devices can be safe and effective for the treatment of drug-resistant epilepsy. A body of scientific work supports peripheral, subcortical and cortical targets, each with different fundamental methods of action. Areas covered: High-quality evidence is available for vagal nerve stimulation (VNS), deep brain stimulation (DBS), and responsive neurostimulation (RNS). Read More

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http://dx.doi.org/10.1080/14737175.2019.1554433DOI Listing
December 2018

Hypothesized mechanisms through which acute exercise influences episodic memory.

Physiol Int 2018 Dec 10;105(4):285-297. Epub 2018 Dec 10.

1 Exercise & Memory Laboratory, Department of Health, Exercise Science and Recreation Management, The University of Mississippi , Oxford, MS, USA.

Emerging research demonstrates that exercise is favorably associated with several cognitive outcomes, including episodic memory function. The majority of the mechanistic work describing the underlying mechanisms of this effect has focused on chronic exercise engagement. Such mechanisms include, e. Read More

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http://dx.doi.org/10.1556/2060.105.2018.4.28DOI Listing
December 2018
1 Read