30,771 results match your criteria Vagus Nerve


Emerging treatments for cluster headache: hopes and disappointments.

Authors:
Delphine Magis

Curr Opin Neurol 2019 Mar 19. Epub 2019 Mar 19.

Headache Research Unit, University Department of Neurology CHR, Centre Hospitalier Universitaire de Liege, Liege, Belgium.

Purpose Of Review: Cluster headache stands among the worst debilitating pain conditions. Available treatments for cluster headache have often disabling side effects, are not tolerated, or are ineffective. The management of drug-refractory chronic forms is challenging. Read More

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http://dx.doi.org/10.1097/WCO.0000000000000693DOI Listing

Thoracic Sympathectomy for Refractory Chest Pain: A Case Report.

A A Pract 2019 Mar 18. Epub 2019 Mar 18.

From the Department of Anesthesiology, Emory University School of Medicine, Atlanta, Georgia.

Pericarditis is a source of chest pain that can be chronic and debilitating. We describe a patient diagnosed with pericarditis with chest pain refractory to medical management. This pain was significantly relieved by a left stellate ganglion block, and a subsequent thoracic chain sympathectomy resulted in 3 months of gradually diminishing relief. Read More

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http://dx.doi.org/10.1213/XAA.0000000000000997DOI Listing

The social brain and heart rate variability: Implications for psychotherapy.

Psychol Psychother 2019 Mar 20. Epub 2019 Mar 20.

School of Human Health Sciences, University of Florence, Italy.

Purpose: Humans evolved within the mammalian line as a highly social species. Indeed, sociality has been a major driver of human social intelligence. From birth, social relationships have emotional and self-regulating properties and operate through different body systems. Read More

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http://dx.doi.org/10.1111/papt.12224DOI Listing

Noninvasive vagus nerve stimulation to target gait impairment in Parkinson's disease.

Mov Disord 2019 Mar 19. Epub 2019 Mar 19.

Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1002/mds.27664DOI Listing

Self-made thoracic needled suspending device with a snare: An excellent aid for uniportal video-assisted thoracic lobectomy and segmentectomy for lung cancer.

Oncol Lett 2019 Apr 12;17(4):3671-3676. Epub 2019 Feb 12.

Department of Thoracic Surgery, Weihai Municipal Hospital, Weihai, Shandong 264200, P.R. China.

Safety and feasibility of the self-made thoracic needled suspending device with a snare in the uniportal video-assisted thoracic lobectomy and segmentectomy for the treatment of non-small cell lung cancer were explored. In total, 80 pulmonary lung major resections (including lobectomy and segmental resections) with systematic mediastinal lymphadenectomy were retrospectively analyzed. Patients were randomly divided into an observation group and a control group. Read More

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http://www.spandidos-publications.com/10.3892/ol.2019.10030
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http://dx.doi.org/10.3892/ol.2019.10030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403500PMC
April 2019
1 Read
0.987 Impact Factor

A case of varicella zoster encephalitis with glossopharyngeal and vagus nerve injury as primary manifestation combined with medulla lesion.

J Int Med Res 2019 Mar 18:300060519833529. Epub 2019 Mar 18.

1 Department of Neurology, Hengshui People's Hospital, Hengshui, China.

Varicella zoster virus (VZV) can invade the brainstem or brain via the glossopharyngeal, vagus , or facial nerve, resulting in brainstem inflammation or encephalitis. We report the case of a 66-year-old male patient with a primary manifestation of medulla injury of the glossopharyngeal and vagus nerves, combined with a medulla lesion, who was misdiagnosed with lateral medullary syndrome. Facial nerve injury and earache subsequently occurred and human herpes virus 3 (VZV) was detected by second-generation sequencing of the cerebrospinal fluid. Read More

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http://dx.doi.org/10.1177/0300060519833529DOI Listing

Usefulness of intraoperative nerve monitoring in esophageal cancer surgery in predicting recurrent laryngeal nerve palsy and its severity.

Gen Thorac Cardiovasc Surg 2019 Mar 15. Epub 2019 Mar 15.

Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Background: Recurrent laryngeal nerve (RLN) palsy is a critical postoperative complication in esophageal cancer surgery. However, intraoperative prediction of its occurrence and severity is difficult. In this prospective study, we evaluated the usefulness of intraoperative nerve monitoring (IONM) in predicting RLN palsy and its severity. Read More

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http://dx.doi.org/10.1007/s11748-019-01107-5DOI Listing
March 2019
1 Read

Vagus Nerve Stimulation as a Treatment for Catatonia: A Hypothesis.

Authors:
David Zilles

Front Psychiatry 2019 27;10:86. Epub 2019 Feb 27.

Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.

Catatonia is a syndrome comprising psychomotor, behavioral, and autonomous symptoms which may occur in the context of severe schizophrenic, affective, and other mental disorders or medical conditions. Treatment options include high dose benzodiazepines (lorazepam) and electroconvulsive therapy (ECT) with some evidence for the effectiveness of glutamate antagonists. However, due to a lack of randomized controlled studies in this severely ill population, evidence base is weak. Read More

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http://dx.doi.org/10.3389/fpsyt.2019.00086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402369PMC
February 2019
1 Read

Transcutaneous auricular vagus nerve stimulation in treating post-stroke insomnia monitored by resting-state fMRI: The first case report.

Brain Stimul 2019 Feb 21. Epub 2019 Feb 21.

Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2019.02.016DOI Listing
February 2019
1 Read

Noninvasive vagus nerve stimulation improves gait and reduces freezing of gait in Parkinson's disease.

Mov Disord 2019 Mar 14. Epub 2019 Mar 14.

Department of Neurology and Ram Gopal Chamaria Medical Research Centre (RGC), Institute of Neurosciences, Kolkata, India.

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http://dx.doi.org/10.1002/mds.27662DOI Listing

Investigating the Effect of Short Term Responsive VNS Therapy on Sleep Quality Using Automatic Sleep Staging.

IEEE Trans Biomed Eng 2019 Mar 8. Epub 2019 Mar 8.

Objective: The goal of this work is to objectively evaluate the effectiveness of responsive (or closed-loop) Vagus nerve stimulation (VNS) therapy in sleep quality in patients with medically refractory epilepsy.

Methods: Using quantitative features obtained from electroencephalography (EEG), we first developed a new automatic sleep-staging framework that consists of a multi-class support vector machine (SVM) classification based on a decision tree approach. To train and evaluate the performance of the framework, we used polysomnographic data of 23 healthy subjects from the PhysioBank database where the sleep stages have been visually annotated. Read More

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http://dx.doi.org/10.1109/TBME.2019.2903987DOI Listing
March 2019
2 Reads

Modified ketogenic diets in adults with refractory epilepsy: Efficacious improvements in seizure frequency, seizure severity, and quality of life.

Epilepsy Behav 2019 Mar 10. Epub 2019 Mar 10.

Rush University Medical Center, 1725 West Harrison Street, Suite 885, Chicago, IL 60612, United States of America. Electronic address:

Objective: This study evaluates the efficacy of a modified ketogenic diet (MKD) on seizure frequency, severity, and quality of life (QOL), as well as potential complications of MKD therapy among adults with drug-resistant epilepsy (DRE).

Methods: Changes in seizure frequency, severity, QOL, and side effects were retrospectively examined among adults, ≥17 years of age, with DRE (≥2 antiepileptic drugs [AEDs]), after 3 months of MKD therapy. Attention was paid to medication or vagus nerve stimulator (VNS) changes as well to evaluate potential confounders. Read More

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http://dx.doi.org/10.1016/j.yebeh.2018.12.010DOI Listing
March 2019
2 Reads

Noninvasive ultrasound stimulation of the spleen to treat inflammatory arthritis.

Nat Commun 2019 Mar 12;10(1):951. Epub 2019 Mar 12.

Department of Biomedical Engineering, University of Minnesota, Minneapolis, 55455, MN, USA.

Targeted noninvasive control of the nervous system and end-organs may enable safer and more effective treatment of multiple diseases compared to invasive devices or systemic medications. One target is the cholinergic anti-inflammatory pathway that consists of the vagus nerve to spleen circuit, which has been stimulated with implantable devices to improve autoimmune conditions such as rheumatoid arthritis. Here we report that daily noninvasive ultrasound (US) stimulation targeting the spleen significantly reduces disease severity in a mouse model of inflammatory arthritis. Read More

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http://www.nature.com/articles/s41467-019-08721-0
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http://dx.doi.org/10.1038/s41467-019-08721-0DOI Listing
March 2019
2 Reads

Noninvasive sub-organ ultrasound stimulation for targeted neuromodulation.

Nat Commun 2019 Mar 12;10(1):952. Epub 2019 Mar 12.

GE Global Research Center, 1 Research Circle, Niskayuna, NY, 12309, USA.

Tools for noninvasively modulating neural signaling in peripheral organs will advance the study of nerves and their effect on homeostasis and disease. Herein, we demonstrate a noninvasive method to modulate specific signaling pathways within organs using ultrasound (U/S). U/S is first applied to spleen to modulate the cholinergic anti-inflammatory pathway (CAP), and US stimulation is shown to reduce cytokine response to endotoxin to the same levels as implant-based vagus nerve stimulation (VNS). Read More

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http://www.nature.com/articles/s41467-019-08750-9
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http://dx.doi.org/10.1038/s41467-019-08750-9DOI Listing
March 2019
1 Read

Durability of symptomatic responses obtained with adjunctive vagus nerve stimulation in treatment-resistant depression.

Neuropsychiatr Dis Treat 2019 13;15:457-468. Epub 2019 Feb 13.

Department of Psychiatry and Behavioral Sciences, National University of Singapore, Singapore.

Objective: To compare the durations of response achieved with adjunctive vagus nerve stimulation (VNS + TAU) vs treatment as usual (TAU) alone in treatment-resistant depression (TRD) over a 5-year period in the TRD registry.

Materials And Methods: Data from 271 participants on TAU and 328 participants on VNS + TAU were analyzed. Response was defined as ≥50% decrease in baseline Montgomery-Åsberg Depression Rating Scale (MADRS) score at postbaseline visit and was considered retained until the decrease was <40%. Read More

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http://dx.doi.org/10.2147/NDT.S196665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387594PMC
February 2019

Reply to the letter to the editor.

J Anesth 2019 Mar 9. Epub 2019 Mar 9.

Department of Anesthesiology and Resuscitology, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto, Nagano, 390-8621, Japan.

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http://dx.doi.org/10.1007/s00540-019-02617-5DOI Listing

Transcranial MEP monitoring of vagus nerve.

J Anesth 2019 Mar 9. Epub 2019 Mar 9.

Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.

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http://dx.doi.org/10.1007/s00540-019-02618-4DOI Listing

[Headache - an Update 2018].

Laryngorhinootologie 2019 Mar 7;98(3):192-217. Epub 2019 Mar 7.

Epidemiological studies have shown a clear correlation between migraine and vascular disease in more and more patients. Pathophysiological studies show the relevance of the hypothalamus in the generation of migraine attacks. Glutamate seems to play an important role here. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0823-4814
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http://dx.doi.org/10.1055/a-0823-4814DOI Listing
March 2019
4 Reads

Medial approach for subcarinal lymphadenectomy during thoracoscopic esophagectomy in the prone position.

Langenbecks Arch Surg 2019 Mar 7. Epub 2019 Mar 7.

Division of Gastrointestinal Surgery, Department of Surgery, Graduate School of Medicine, Kobe University, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.

Purpose: In esophageal squamous cell carcinoma (ESCC), lymph nodes (LNs) around the subcarina and main bronchi are thought to be highly involved. Therefore, complete dissection of these LNs with preservation of the pulmonary branches of the vagus nerves, which control important pulmonary functions, is recommended. The aim of this retrospective study was to investigate the feasibility of reliable method for lymphadenectomy around the subcarina and main bronchi, named the medial approach, during thoracoscopic esophagectomy in the prone position (TEP). Read More

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http://dx.doi.org/10.1007/s00423-019-01772-3DOI Listing

Extensive Lymph Node Dissection Around the Left Laryngeal Nerve Achieved With Robot-assisted Thoracoscopic Esophagectomy.

Anticancer Res 2019 Mar;39(3):1337-1342

Thoracic Surgery, Akita University Graduate School of Medicine, Akita, Japan.

Background/aim: The potential advantages of robot-assisted thoracoscopic esophagectomy (RATE) have yet to be verified. This study focused on the degree of lymph node dissection around the left recurrent laryngeal nerve (RLN).

Patients And Methods: A total of 21 consecutive patients who received RATE (RATE group) and 38 who received conventional thoracoscopic esophagectomy (TE) (TE group), both with extended lymphadenectomy, for thoracic squamous cell esophageal carcinoma, were enrolled in this study. Read More

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http://dx.doi.org/10.21873/anticanres.13246DOI Listing

Adenosine triphosphate is co-secreted with glucagon-like peptide-1 to modulate intestinal enterocytes and afferent neurons.

Nat Commun 2019 Mar 4;10(1):1029. Epub 2019 Mar 4.

Metabolic Research Laboratories, Wellcome Trust MRC Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK.

Enteroendocrine cells are specialised sensory cells located in the intestinal epithelium and generate signals in response to food ingestion. Whilst traditionally considered hormone-producing cells, there is evidence that they also initiate activity in the afferent vagus nerve and thereby signal directly to the brainstem. We investigate whether enteroendocrine L-cells, well known for their production of the incretin hormone glucagon-like peptide-1 (GLP-1), also release other neuro-transmitters/modulators. Read More

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http://dx.doi.org/10.1038/s41467-019-09045-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399286PMC

Multimodality imaging of paragangliomas of the head and neck.

Insights Imaging 2019 Mar 4;10(1):29. Epub 2019 Mar 4.

University of Rochester Medical Center, Rochester, USA.

Paragangliomas arise from paraganglion cells which serve varied regulatory tasks in the body. When these cells demonstrate neoplasia within the head and neck, they typically present in characteristic locations including the carotid space, the jugular foramen, the middle ear, and along the course of the vagus nerve. The goal of this article is to review the relevant anatomy related to head and neck paragangliomas, as well as their typical imaging characteristics on cross-sectional imaging including CT, MR, ultrasound, and nuclear medicine studies. Read More

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http://dx.doi.org/10.1186/s13244-019-0701-2DOI Listing
March 2019
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Transjugular transsigmoid approach for triple dumbbell-shaped jugular foramen schwannomas.

Acta Neurochir (Wien) 2019 Mar 4. Epub 2019 Mar 4.

Department of Neurosurgery, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.

Background: Jugular foramen tumors, particularly those that are triple dumbbell-shaped with intracranial, intraforaminal, and extracranial extensions, are difficult to access surgically. However, advances in neuroimaging, neuromonitoring, and skull base surgery have enabled their safe resection with lower rates of morbidity and mortality.

Method: We share our experience with the surgical technique for the management of triple dumbbell-shaped jugular foramen schwannomas. Read More

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http://dx.doi.org/10.1007/s00701-019-03860-1DOI Listing

Disentangling What We Know About Microbes and Mental Health.

Authors:
Gregor Reid

Front Endocrinol (Lausanne) 2019 15;10:81. Epub 2019 Feb 15.

Canadian R&D Centre for Human Microbiome and Probiotics, Lawson Health Research Institute, London, ON, Canada.

Much has been written in recent years about the gut-brain axis. Exciting pilot studies suggest probiotic applications to the gut can reduce anxiety and depression via the vagus nerve. But not to diminish such findings, much still needs to be considered, including the fact that the vagus nerve links to many other body sites that also host a microbiome. Read More

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http://dx.doi.org/10.3389/fendo.2019.00081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384226PMC
February 2019

Comparison of the efficiency of chopped and non-rectangular electrical stimulus waveforms in activating small vagus nerve fibers.

J Neurosci Methods 2019 Mar 1;320:1-8. Epub 2019 Mar 1.

INRIA, University of Montpellier, Montpellier, France.

Background: In the context of morbid obesity, vagus nerve stimulation could be used to control gastric function targeting the small afferent B-fibers and C-fibers. Compared to large A-fibers, activation thresholds of these small efferent fibers are 10 to 100 times greater, inducing technical constraints and possible nerve damages. Although rectangular waveform is commonly used in nerve stimulation, recent modeling and experimental studies suggest that non-rectangular waveforms could reduced the charge injected by the stimulator. Read More

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http://dx.doi.org/10.1016/j.jneumeth.2019.02.017DOI Listing

How breathing can help you make better decisions: Two studies on the effects of breathing patterns on heart rate variability and decision-making in business cases.

Int J Psychophysiol 2019 Mar 1;139:1-9. Epub 2019 Mar 1.

SCALab, Lille 3 University & Siric Oncolille, Lille, France.

Deep slow breathing can increase vagal nerve activity, indexed by heart rate variability (HRV). HRV is also associated with better decision-making. This research examined the effects of two breathing patterns on HRV (Study 1) and on stress and decision-making performance (Study 2). Read More

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http://dx.doi.org/10.1016/j.ijpsycho.2019.02.011DOI Listing

Non-invasive neuromodulation for migraine and cluster headache: a systematic review of clinical trials.

J Neurol Neurosurg Psychiatry 2019 Mar 1. Epub 2019 Mar 1.

Headache and Craniofacial Pain Unit, Neurology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

Non-invasive neuromodulation therapies for migraine and cluster headache are a practical and safe alternative to pharmacologics. Comparisons of these therapies are difficult because of the heterogeneity in study designs. In this systematic review of clinical trials, the scientific rigour and clinical relevance of the available data were assessed to inform clinical decisions about non-invasive neuromodulation. Read More

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http://dx.doi.org/10.1136/jnnp-2018-320113DOI Listing
March 2019
1 Read

30 years of vagus nerve stimulation trials in epilepsy: Do we need neuromodulation-specific trial designs?

Epilepsy Res 2019 Feb 20. Epub 2019 Feb 20.

Laboratory for Clinical and Experimental Neurophysiology, Neurobiology and Neuropsychology, Department of Neurology, Ghent University, Ghent, Belgium.

Neuromodulation therapies represent an important treatment arm for patients with drug-resistant epilepsy (DRE) who are not candidates for resective surgery. Vagus nerve stimulation (VNS) - the neurostimulation modality in focus in this review - was the first available neuromodulatory therapy for DRE and was followed by anterior thalamic deep brain stimulation (ANT-DBS) and responsive neurostimulation (RNS). Although no comparative trials of these treatments have been performed, published data and clinical experience suggest comparable effectiveness. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09201211183057
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http://dx.doi.org/10.1016/j.eplepsyres.2019.02.004DOI Listing
February 2019
2 Reads
2.015 Impact Factor

Interplay of spinal and vagal pathways on esophageal acid-related anterior cingulate cortex functional networks in rats.

Am J Physiol Gastrointest Liver Physiol 2019 Feb 28. Epub 2019 Feb 28.

Division of Gastroenterology & Hepatology, Medical College of Wisconsin, United States.

Background & Aims: Esophageal acid sensory signals are transmitted by both vagal and spinal pathways to the cerebral cortex. The influence and interplay of these pathways on the esophageal acid-related functional connectivity has been elusive. The aim is to evaluate the esophageal acid exposure-related effect on the anterior cingulate cortex (ACC) functional connectivity networks using functional MRI-guided functional connectivity MRI (fcMRI) analysis. Read More

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http://dx.doi.org/10.1152/ajpgi.00228.2018DOI Listing
February 2019

Vagus Nerve Stimulation (VNS) in Super Refractory New Onset Refractory Status Epilepticus (NORSE).

Case Rep Neurol Med 2019 21;2019:7852017. Epub 2019 Jan 21.

Department of Neurocritical Care, Inova Fairfax Hospital, Falls Church, VA, USA.

The treatment protocol of status epilepticus has many associated toxicities so there is interest in alternate nonmedicinal therapies for managing New Onset Refractory Status Epilepticus (NORSE) patients. Vagus nerve stimulation (VNS) is an FDA-approved therapy for refractory epilepsy that has been shown to decrease the frequency and severity of seizures. We present the case of a patient with new-onset refractory status epilepticus (NORSE) whose seizures were successfully treated with vagus nerve stimulation. Read More

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http://dx.doi.org/10.1155/2019/7852017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360559PMC
January 2019
2 Reads

Multiscale Fine-Grained Heart Rate Variability Analysis for Recognizing the Severity of Hypertension.

Comput Math Methods Med 2019 22;2019:4936179. Epub 2019 Jan 22.

School of Computer Science, Northwestern Polytechnical University, Xi'an 710072, China.

Hypertension is a common and chronic disease and causes severe damage to patients' health. Blood pressure of a human being is controlled by the autonomic nervous system. Heart rate variability (HRV) is an impact of the autonomic nervous system and an indicator of the balance of the cardiac sympathetic nerve and vagus nerve. Read More

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http://dx.doi.org/10.1155/2019/4936179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362500PMC
January 2019
0.766 Impact Factor

Cognition-Enhancing Vagus Nerve Stimulation Alters the Epigenetic Landscape.

J Neurosci 2019 Feb 25. Epub 2019 Feb 25.

Department of Pharmacology, Vanderbilt University, Nashville, TN, USA.

Vagus Nerve Stimulation (VNS) has been shown to enhance learning and memory, yet the mechanisms behind these enhancements are unknown. Here we present evidence that epigenetic modulation underlies VNS-induced improvements in cognition. We show that VNS enhances novelty preference, alters the hippocampal, cortical, and blood epigenetic transcriptomes, and epigenetically modulates neuronal plasticity and stress-response signaling genes in male Sprague-Dawley rats. Read More

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http://dx.doi.org/10.1523/JNEUROSCI.2407-18.2019DOI Listing
February 2019

The influence of respiration on brainstem and cardiovagal response to auricular vagus nerve stimulation: A multimodal ultrahigh-field (7T) fMRI study.

Brain Stimul 2019 Feb 10. Epub 2019 Feb 10.

Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA; Department of Radiology, Logan University, Chesterfield, MO, USA.

Background: Brainstem-focused mechanisms supporting transcutaneous auricular VNS (taVNS) effects are not well understood, particularly in humans. We employed ultrahigh field (7T) fMRI and evaluated the influence of respiratory phase for optimal targeting, applying our respiratory-gated auricular vagal afferent nerve stimulation (RAVANS) technique.

Hypothesis: We proposed that targeting of nucleus tractus solitarii (NTS) and cardiovagal modulation in response to taVNS stimuli would be enhanced when stimulation is delivered during a more receptive state, i. Read More

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http://dx.doi.org/10.1016/j.brs.2019.02.003DOI Listing
February 2019
1 Read

Predictors of seizure reduction outcome after vagus nerve stimulation in drug-resistant epilepsy.

Seizure 2019 Feb 15;66:53-60. Epub 2019 Feb 15.

Department of Neurology, West China Hospital, Sichuan University, Wai Nan Guo Xue Lane 37 #, Chengdu 610041, Sichuan, China. Electronic address:

Purpose: To evaluate the predictors of seizure reduction outcome after vagus nerve stimulation (VNS) in patients with drug-resistant epilepsy (DRE).

Methods: A meta-analysis was performed using relevant research from databases such as PubMed, Embase, Cochrane Online Library, and Clinicaltrials.gov. Read More

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http://dx.doi.org/10.1016/j.seizure.2019.02.010DOI Listing
February 2019
1 Read

Accumulation of prion protein in the vagus nerve in creutzfeldt-jakob disease.

Ann Neurol 2019 Feb 23. Epub 2019 Feb 23.

Institute of Neurology, Medical University of Vienna, Vienna, Austria.

Disease-associated proteins are thought to propagate along neuronal processes in neurodegenerative diseases. To detect disease-associated prion protein (PrP ) in the vagus nerve in different forms and molecular subtypes of Creutzfeldt-Jakob disease (CJD), we applied 3 different anti-PrP antibodies. We screened the vagus nerve in 162 sporadic and 30 genetic CJD cases. Read More

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http://doi.wiley.com/10.1002/ana.25451
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http://dx.doi.org/10.1002/ana.25451DOI Listing
February 2019
2 Reads

Saliva molecular inflammatory profiling in female migraine patients responsive to adjunctive cervical non-invasive vagus nerve stimulation: the MOXY Study.

J Transl Med 2019 Feb 22;17(1):53. Epub 2019 Feb 22.

Department of Psychiatry, University Hospital Bonn, Bonn, Germany.

Background: Rising evidence indicate that oxytocin and IL-1β impact trigemino-nociceptive signaling. Current perspectives on migraine physiopathology emphasize a cytokine bias towards a pro-inflammatory status. The anti-nociceptive impact of oxytocin has been reported in preclinical and human trials. Read More

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http://dx.doi.org/10.1186/s12967-019-1801-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387501PMC
February 2019

Extracranial internal carotid artery tortuosity may cause vocal cord palsy.

Acta Otolaryngol 2019 Feb 22:1-5. Epub 2019 Feb 22.

c Department of Otorhinolaryngology and Maxillofacial Surgery, Sjaellands Universitetshospital Køge , Køge , Denmark.

Background: Clinical practice made us suspect that vocal cord palsy (VCP) can be associated with extracranial internal carotid artery (ICA) tortuosity.

Objectives: To find evidence for a causative relation between ICA tortuosity and VCP.

Methods: This single-center, retrospective study comprised 66 patients with VCP. Read More

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http://dx.doi.org/10.1080/00016489.2018.1554263DOI Listing
February 2019

Forced normalization after turning off vagus nerve stimulation in Lennox-Gastaut syndrome.

Epilepsy Behav Case Rep 2019 27;11:81-83. Epub 2019 Jan 27.

Division of Neurology, Department of Medicine, University of Saskatchewan, Saskatoon, Canada.

Forced normalization is the development of psychiatric symptoms in a patient experiencing remission of seizures. We present a case of Lennox Gastaut syndrome in which forced normalization developed after vagus nerve stimulation was stopped. The patient had drug resistant epilepsy and failed anti-seizure drugs, vagus nerve stimulation, and a partial callosotomy. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22133232183017
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http://dx.doi.org/10.1016/j.ebcr.2019.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369242PMC
January 2019
2 Reads

Vagus nerve stimulation for primary headache disorders: An anatomical review to explain a clinical phenomenon.

Cephalalgia 2019 Feb 20:333102419833076. Epub 2019 Feb 20.

4 Department of Anesthesiology, Pain and Palliative Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.

Background: Non-invasive stimulation of the vagus nerve has been proposed as a new neuromodulation therapy to treat primary headache disorders, as the vagus nerve is hypothesized to modulate the headache pain pathways in the brain. Vagus nerve stimulation can be performed by placing an electrode on the ear to stimulate the tragus nerve, which contains about 1% of the vagus fibers. Non-invasive vagus nerve stimulation (nVNS) conventionally refers to stimulation of the cervical branch of the vagus nerve, which is made up entirely of vagal nerve fibers. Read More

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http://dx.doi.org/10.1177/0333102419833076DOI Listing
February 2019
1 Read

Effect of dispersion in nerve on compound action potential and impedance change: a modelling study.

Physiol Meas 2019 Feb 20. Epub 2019 Feb 20.

Department of Medical Physics and Bioengineering, University College London, London, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Objective: Electrical impedance tomography (EIT) is capable of imaging fast compound electrical activity (Compound Action Potentials, or CAPs) inside peripheral nerves. The ability of EIT to detect impedance changes (dZ) which arise from the opening of ion channels during the CAP is limited by the dispersion with distance from the site of onset, as fibres have differing conduction velocities. The effect is largest for autonomic nerves mainly formed of slower conducting unmyelinated fibres where signals cannot be recorded more than a few cm away from the stimulation. Read More

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http://dx.doi.org/10.1088/1361-6579/ab08ceDOI Listing
February 2019

Berardinelli-Seip syndrome and progressive myoclonus epilepsy.

Epileptic Disord 2019 Feb;21(1):117-121

Child Neurology and Psychiatry Unit, "Regina Montis Regalis" Hospital, Mondovì.

Berardinelli-Seip syndrome, or congenital generalized lipodystrophy type 2 (CGL2), is characterized by a lack of subcutaneous adipose tissue and precocious metabolic syndrome with insulin resistance, resulting in diabetes, dyslipidaemia, hepatic steatosis, cardiomyopathy, and acanthosis nigricans. Most reported mutations are associated with mild, non-progressive neurological impairment. We describe the clinical and EEG data of a patient with progressive myoclonus epilepsy (PME), CGL2, and progressive neurological impairment, carrying a homozygous BSCL2 nonsense mutation. Read More

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http://dx.doi.org/10.1684/epd.2019.1038DOI Listing
February 2019
4 Reads

A Rasmussen encephalitis, autoimmune encephalitis, and mitochondrial disease mimicker: expanding the DNM1L-associated intractable epilepsy and encephalopathy phenotype.

Epileptic Disord 2019 Feb;21(1):112-116

Department of Pediatric Epilepsy, Beaumont Health, Royal Oak, MI 48073.

Dynamin-1-like protein (DNM1L) gene variants have been linked to childhood refractory epilepsy, developmental delay, encephalopathy, microcephaly, and progressive diffuse cerebral atrophy. However, only a few cases have been reported in the literature and there is still a limited amount of information about the symptomatology and pathophysiology associated with pathogenic variants of DNM1L. We report a 10-year-old girl with a one-year history of mild learning disorder and absence seizures who presented with new-onset focal status epilepticus which progressed to severe encephalopathy and asymmetric hemispheric cerebral atrophy. Read More

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http://dx.doi.org/10.1684/epd.2019.1036DOI Listing
February 2019
2 Reads

Microsurgical technique for concurrent cervical corpectomy and ventral phrenic nerve access in the rat.

MethodsX 2019 13;6:239-245. Epub 2018 Aug 13.

Dept. of Neurobiology & Anatomy, Drexel University College of Medicine, 2900, Queen Lane, Philadelphia, PA, 19129, USA.

The phrenic nerve is useful to record as a motor output in studies investigating neural control of respiration. It may be accessed via dorsal or ventral microsurgical approaches. Since such studies frequently involve concurrent access to the spinal cord, the two approaches may be alternatively used, each with its own set of advantages and disadvantages. Read More

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http://dx.doi.org/10.1016/j.mex.2018.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360515PMC

Vagus Nerve Stimulation for Depression: A Systematic Review.

Front Psychol 2019 31;10:64. Epub 2019 Jan 31.

The Second Medical College, Nanjing University of Chinese Medicine, Nanjing, China.

Depression is a common mental disorder worldwide. Psychological treatments and antidepressant medication are the usual treatments for depression. However, a large proportion of patients with depression do not respond to the treatments. Read More

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http://dx.doi.org/10.3389/fpsyg.2019.00064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365437PMC
January 2019
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Chronic Low-Level Vagus Nerve Stimulation Improves Long-Term Survival in Salt-Sensitive Hypertensive Rats.

Front Physiol 2019 31;10:25. Epub 2019 Jan 31.

Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, United States.

Chronic hypertension (HTN) affects more than 1 billion people worldwide, and is associated with an increased risk of cardiovascular disease. Despite decades of promising research, effective treatment of HTN remains challenging. This work investigates vagus nerve stimulation (VNS) as a novel, device-based therapy for HTN treatment, and specifically evaluates its effects on long-term survival and HTN-associated adverse effects. Read More

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http://dx.doi.org/10.3389/fphys.2019.00025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365472PMC
January 2019
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Syncope after administration of epidural analgesia in an obstetric patient with a vagus nerve stimulator.

Authors:
J E Tang J B Hyman

Int J Obstet Anesth 2019 Jan 6. Epub 2019 Jan 6.

Department of Anesthesiology, Perioperative and Pain Medicine, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place Box 1010, New York, NY 10029, United States. Electronic address:

Vagus nerve stimulation (VNS) is an adjunctive therapy for medically refractory epilepsy and depression. Vagus nerve stimulation is generally well-tolerated, but cardiac arrhythmias or asystole are rare complications that have been reported. This case report describes an obstetric patient who received epidural analgesia and subsequently experienced two episodes of syncope synchronous with stimulation from her VNS device. Read More

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http://dx.doi.org/10.1016/j.ijoa.2018.12.011DOI Listing
January 2019
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Retrosigmoid Intradural Suprajugular Approach to Jugular Foramen Tumors with Intraforaminal Extension: Surgical Series of 19 Cases.

World Neurosurg 2019 Feb 11. Epub 2019 Feb 11.

Department of Neurosurgery, Tokyo Metropolitan Police Hospital, Nakano-ku, Tokyo, Japan.

Objective: The intraforaminal component of jugular foramen tumors is difficult to access surgically, as it requires complex approaches for radical removal and leads to a high recurrence due to residual tumor. The retrosigmoid suprajugular approach, intradural drilling of the roof of the jugular foramen, has been recently proposed for removal of such intraforaminal component without sacrificing the sigmoid-jugular venous system or requiring additional approaches. This study presents our experience with this approach and introduces the use of intraoperative continuous vagus nerve monitoring. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.223DOI Listing
February 2019

Matured Hop Bitter Acids in Beer Improve Lipopolysaccharide-Induced Depression-Like Behavior.

Front Neurosci 2019 28;13:41. Epub 2019 Jan 28.

Research Laboratories for Health Science and Food Technologies, Kirin Company, Ltd., Yokohama, Japan.

Recent studies have demonstrated a close association between neural inflammation and development of mental illnesses, such as depression. Clinical trials have reported that treatment with non-steroidal anti-inflammatory drugs is associated with reduced risk of depression. Moreover, nutritional approaches for the prevention and management of depression have garnered significant attention in recent years. Read More

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http://dx.doi.org/10.3389/fnins.2019.00041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362420PMC
January 2019

Noninvasive vagus nerve stimulation alters neural response and physiological autonomic tone to noxious thermal challenge.

PLoS One 2019 13;14(2):e0201212. Epub 2019 Feb 13.

VA Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, La Jolla, CA, United States of America.

The mechanisms by which noninvasive vagal nerve stimulation (nVNS) affect central and peripheral neural circuits that subserve pain and autonomic physiology are not clear, and thus remain an area of intense investigation. Effects of nVNS vs sham stimulation on subject responses to five noxious thermal stimuli (applied to left lower extremity), were measured in 30 healthy subjects (n = 15 sham and n = 15 nVNS), with fMRI and physiological galvanic skin response (GSR). With repeated noxious thermal stimuli a group × time analysis showed a significantly (p < . Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0201212PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373934PMC
February 2019

Differentiation Between Guillain-Barré Syndrome and Acute-Onset Chronic Inflammatory Demyelinating Polyradiculoneuritis-a Prospective Follow-up Study Using Ultrasound and Neurophysiological Measurements.

Neurotherapeutics 2019 Feb 12. Epub 2019 Feb 12.

Center of Neurology, Tübingen University Hospital, Hoppe-Seyler-Straße 3, 72076, Tübingen, Germany.

Differentiation of Guillain-Barré syndrome (GBS) and acute-onset chronic inflammatory demyelinating polyradiculoneuritis (CIDP) might be intricate in early stages. We compared electrodiagnostics (EDx) and nerve ultrasound (NUS) as tools for early distinction and follow-up. NUS and EDx have been performed at first visitation and after 6 months. Read More

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http://dx.doi.org/10.1007/s13311-019-00716-5DOI Listing
February 2019
2 Reads