14,335 results match your criteria Vaginitis


Comparative Assessment of the Content of Immunoglobulins in the Blood Serum of Calves Obtained From Healthy Cows and Cows with Genital Mycoplasmosis.

FASEB J 2022 May;36 Suppl 1

Saint-Petersburg State University of Veterinary Medicine, Saint-Petersburg.

The genital form of mycoplasmosis is a common disease among cattle in the North-West region of the Russian Federation. In the initial period of illness, cows retain reproductive function and are capable of maintaining pregnancy. It is known that any mother's illness during pregnancy affects the fetus's body, including its immune system. Read More

View Article and Full-Text PDF

An Overview of Mucosa-Associated Protozoa: Challenges in Chemotherapy and Future Perspectives.

Front Cell Infect Microbiol 2022 25;12:860442. Epub 2022 Apr 25.

Laboratório de Estudos Integrados em Protozoologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil.

Parasitic infections caused by protozoans that infect the mucosal surfaces are widely neglected worldwide. Collectively, spp. and infect more than a billion people in the world, being a public health problem mainly in developing countries. Read More

View Article and Full-Text PDF

Survey of incidence, lifetime prevalence, and treatment of self-reported vulvovaginal candidiasis, United States, 2020.

BMC Womens Health 2022 May 10;22(1):147. Epub 2022 May 10.

Division of Foodborne, Waterborne, and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Mailstop H24-9, Atlanta, GA, 30329, USA.

Background: Vulvovaginal candidiasis (VVC) is a common gynecologic problem in the United States but estimates of its true incidence and prevalence are lacking. We estimated self-reported incidence and lifetime prevalence of healthcare provider-diagnosed VVC and recurrent VVC (RVVC), assessed treatment types, and evaluated demographic and health-related risk factors associated with VVC.

Methods: An online survey sent to 4548 U. Read More

View Article and Full-Text PDF

Vaginal Vitamin E for Treatment of Genitourinary Syndrome of Menopause: A Systematic Review of Randomized Controlled Trials.

J Menopausal Med 2022 Apr;28(1):9-16

Department of Family Medicine, University of Texas Medical Branch, Galveston, TX, USA.

Genitourinary syndrome of menopause significantly affects the quality of life in postmenopausal women with few evidence-based alternatives to vaginal estrogen for women with contraindications. This systematic review evaluates the evidence for vaginal vitamin E efficacy in reducing patient-reported genitourinary symptoms in healthy postmenopausal women compared to placebo or vaginal control therapy. This systematic review evaluated randomized controlled trials before October 2020 that assessed the efficacy of vitamin E vaginal suppositories in reducing genitourinary symptoms in postmenopausal women compared with a control group of healthy postmenopausal women. Read More

View Article and Full-Text PDF

[Butyl alcohol extract of Baitouweng Decoction alleviates vulvovaginal candidiasis in mice by downregulating NLRP3 inflammasome and related signal pathways].

Zhongguo Zhong Yao Za Zhi 2022 May;47(9):2516-2524

School of Integrated Traditional Chinese and Western Medicine, Anhui University of Chinese Medicine Hefei 230012, China Institute of Integrated Traditional Chinese and Western Medicine, Anhui Academy of Chinese Medicine Hefei 230012, China Anhui Province Key Laboratory of Chinese Medicinal Formula, Anhui University of Chinese Medicine Hefei 230012, China.

This study aims to explore the effect of butyl alcohol extract of Baitouweng Decoction(BAEB) on vulvovaginal candidiasis(VVC) in mice and to clarify the mechanism from Toll-like receptors(TLRs)/MyD88 and Dectin-1/Syk signal pathways and NLRP3 inflammasome. To be specific, female KM mice were randomized into control group(i.g. Read More

View Article and Full-Text PDF

: A Phytochemical and Pharmacological Review.

Evid Based Complement Alternat Med 2022 29;2022:3742208. Epub 2022 Apr 29.

School of Traditional Chinese Medicine, Capital Medical University, Youanmenwai, Xitoutiao, Fengtai District, Beijing 100069, China.

Ledeb., which belongs to Agrimonia and Rosaceae, is used in traditional Chinese medicine. It exhibits excellent medicinal properties and has been used to treat various diseases, such as tumors, trichomoniasis, vaginitis, diarrhea, and dysentery. Read More

View Article and Full-Text PDF

The associations between low abundance of Mycoplasma hominis and female fecundability: a pregnancy-planning cohort study.

BMC Microbiol 2022 05 5;22(1):121. Epub 2022 May 5.

Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, 87#, Dingjiaqiao Road, Gulou District, Nanjing City, Jiangsu Province, China.

Objective: To explore the impact of pre-pregnancy vaginal Mycoplasma hominis (M. hominis) colonization of low abundance on female fecundability.

Methods: In total, 89 females participating in a pre-pregnancy health examination program were included, and their pregnancy outcomes were followed up for 1 year. Read More

View Article and Full-Text PDF

Ibrexafungerp in the Treatment of Vulvovaginal Candidiasis.

Ann Pharmacother 2022 May 2:10600280221091301. Epub 2022 May 2.

Pharmacy Practice, University of Health Sciences and Pharmacy, St. Louis, MO, USA.

Objective: To review the pharmacology, efficacy, and safety of ibrexafungerp in the management of vulvovaginal candidiasis (VVC).

Data Sources: Literature was sought using PubMed (1966-February 2022) and EMBASE (1973-February 2022), and clinicaltrials.gov. Read More

View Article and Full-Text PDF

The right bug in the right place: opportunities for bacterial vaginosis treatment.

NPJ Biofilms Microbiomes 2022 May 2;8(1):34. Epub 2022 May 2.

Centre for Translational Microbiome Research (CTMR), Department of Microbiology, Tumor, and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

Bacterial vaginosis (BV) is a condition in which the vaginal microbiome presents an overgrowth of obligate and facultative anaerobes, which disturbs the vaginal microbiome balance. BV is a common and recurring vaginal infection among women of reproductive age and is associated with adverse health outcomes and a decreased quality of life. The current recommended first-line treatment for BV is antibiotics, despite the high recurrence rate. Read More

View Article and Full-Text PDF

Possible misdiagnosis, inappropriate empiric treatment, and opportunities for increased diagnostic testing for patients with vulvovaginal candidiasis-United States, 2018.

PLoS One 2022 28;17(4):e0267866. Epub 2022 Apr 28.

Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America.

Vulvovaginal candidiasis (VVC) is a common cause of vaginitis, but the national burden is unknown, and clinical diagnosis without diagnostic testing is often inaccurate. We aimed to calculate rates and evaluate diagnosis and treatment practices of VVC and recurrent vulvovaginal candidiasis (RVVC) in the United States. We used the 2018 IBM® MarketScan® Research Databases, which include health insurance claims data on outpatient visits and prescriptions for >28 million people. Read More

View Article and Full-Text PDF

infection in a pregnant woman: a case report.

Curr Med Res Opin 2022 May 13:1-4. Epub 2022 May 13.

Department of Gynecology, The Third People's Hospital of Qingdao, Qingdao, China.

Background: belongs is a gram-positive anaerobic coccus (GPAC), which can cause bacterial vaginitis. However, only a few studies have reported severe infection of . This study presented the first case of severe infection of during pregnancy. Read More

View Article and Full-Text PDF

Vaginitis in the Age of the Microbiome.

J Womens Health (Larchmt) 2022 Apr;31(4):459-461

Depatment of Medicine and Biological Sciences, Brown University, Providence, Rhode Island, USA.

View Article and Full-Text PDF

Comparison of Five Protocols of Estrous Synchronization on Reproductive Performance of Hu Sheep.

Front Vet Sci 2022 5;9:843514. Epub 2022 Apr 5.

College of Animal Science and Technology, Hebei North University, Zhangjiakou, China.

The purpose of this study is to compare five protocols of estrous synchronization for Hu ewes to obtain the most effective and economical protocol, to apply the advantageous scheme in large-scale sheep farming. Healthy multiparous Hu ewes ( = 150) were randomly divided into five groups, and all ewes were administered fluorogestone acetate (FGA, 45 mg) vaginal sponge. The sponges of the first three groups (Groups I, II, and III) were removed on the 11th day, and 0. Read More

View Article and Full-Text PDF

A cross-sectional analysis about bacterial vaginosis, high-risk human papillomavirus infection, and cervical intraepithelial neoplasia in Chinese women.

Sci Rep 2022 Apr 22;12(1):6609. Epub 2022 Apr 22.

Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China.

Bacterial vaginosis (BV) is a genital infection that frequently presents in women infected with human papillomavirus (HPV), but the correlation between BV, HPV and cervical intraepithelial neoplasia (CIN) development is still elusive. We organized a cross-sectional analysis which enrolled 624 participants and obtained 423 samples of vaginal secretions from them, including 193 HPV-negative samples and 230 HR-HPV-positive samples. We used 16S rRNA sequencing to measure the vaginal microbiota diversity in women with different BV, HPV and CIN status, and then calculated risk factors for CIN by logistic regression. Read More

View Article and Full-Text PDF

Genistein Up-Regulates the Expression of EGF and E-Cadherin in the Treatment of Senile Vaginitis.

Molecules 2022 Apr 7;27(8). Epub 2022 Apr 7.

Heilongjiang Academy of Chinese Medicine Sciences, Harbin 150040, China.

Investigating the therapeutic effect of genistein (Gen) on postmenopausal senile vaginitis (SV) and its mechanism of action. Adult SPF female Wistar rats were selected to establish a bilateral ovariectomized animal model (OVX), which simulated senile vaginitis dominated by estrogen deficiency in ovarian dysfunction. After 14 days of continuous treatment, the morphology of vaginal epithelial tissue was observed and various types of epithelial cells were counted, and the body mass and uterine and vaginal index of rats were measured. Read More

View Article and Full-Text PDF

Identification and characterization of novel endolysins targeting Gardnerella vaginalis biofilms to treat bacterial vaginosis.

NPJ Biofilms Microbiomes 2022 Apr 19;8(1):29. Epub 2022 Apr 19.

Division of Biosciences, Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge, UB8 3PH, UK.

Bacterial vaginosis (BV) is a recurrent dysbiosis that is frequently associated with preterm birth, increased risk for acquisition of human immunodeficiency virus (HIV) and other sexually transmitted infections (STIs). The overgrowth of a key pathobiont, Gardnerella vaginalis, as a recalcitrant biofilm is central to the development of this dysbiosis. Overgrowth of vaginal biofilms, seeded by initial G. Read More

View Article and Full-Text PDF

Vaginal Infections' Etiologies in South-Eastern Gabon - An Overview.

Int J Womens Health 2022 12;14:505-515. Epub 2022 Apr 12.

Medical Analysis Research Unit (URAM)/Bacteriology, International Center for Medical Research (CIRMF), Franceville, BP 769, Gabon.

Introduction: Discomfort in women of childbearing age associated with vaginal infections, namely bacterial vaginosis (BV), aerobic vaginitis (AV), vulvovaginal candidiasis (VVC), and trichomoniasis (TV), represent a serious and ongoing gynecological complication throughout the world.

Objective: This study aimed to investigate the etiologies of vaginal infections among outpatients in south-eastern Gabon.

Methodology: A cross-sectional study was designed using participants referred directly by their treating doctor for a vaginal swab. Read More

View Article and Full-Text PDF

Oral vs. Intravaginal Antifungal Treatments for Uncomplicated Vulvovaginal Candidiasis.

Am Fam Physician 2022 04;105(4):367-368

Penn State Health St. Joseph Family Medicine Residency Program, Reading, PA, USA.

View Article and Full-Text PDF

Mixed Vaginitis in the Third Trimester of Pregnancy Is Associated With Adverse Pregnancy Outcomes: A Cross-Sectional Study.

Front Cell Infect Microbiol 2022 28;12:798738. Epub 2022 Mar 28.

Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, China.

Mixed vaginitis is a complex vaginal dysbiosis that differs from single vaginitis. Vaginitis in the third trimester may lead to adverse maternal and neonatal outcomes. The clinical characteristics, microbiological characteristics, and adverse pregnancy outcomes of mixed vaginitis in late pregnancy are worth studying. Read More

View Article and Full-Text PDF

Comparing the Effectiveness of with ClotrimazoleVaginal Cream for the Treatment of Vulvovaginal Candidiasis: A Randomized Controlled Triple-Blind Trial.

Iran J Nurs Midwifery Res 2022 Mar-Apr;27(2):112-118. Epub 2022 Mar 14.

Department of Biostatistics and Epidemiology, Faculty of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Vulvovaginal candidiasis is the second most common cause of vulvovaginal infections. Due to the increasing resistance to synthetic antifungal drugs, the use of drugs with a natural origin is a priority. The aim of the present study was to compare the effectiveness of with vaginal cream clotrimazole 1% United States Pharmacopeia (USP) for the treatment of vulvovaginal candidiasis. Read More

View Article and Full-Text PDF

Diagnosis and Management of Trichomonas vaginalis: Summary of Evidence Reviewed for the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines.

Clin Infect Dis 2022 Apr;74(Supplement_2):S152-S161

Division of Sexually Transmitted Diseases Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Trichomonas vaginalis is likely the most prevalent nonviral sexually transmitted infection, affecting an estimated 3.7 million women and men in the United States. Health disparities are prominent in the epidemiology of trichomoniasis, as African Americans are >4 times more likely to be infected than persons of other races. Read More

View Article and Full-Text PDF

Diagnosis and Management of Bacterial Vaginosis: Summary of Evidence Reviewed for the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines.

Clin Infect Dis 2022 Apr;74(Supplement_2):S144-S151

Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, Alabama, USA.

In preparation for the 2021 Centers for Disease Control and Prevention (CDC) sexually transmitted infections (STIs) treatment guidelines, the CDC convened an advisory group in 2019 to examine recent literature addressing updates in the epidemiology, diagnosis, and management of STIs. This article summarizes recent data in each of these key topic areas as they pertain to bacterial vaginosis (BV), the most common cause of vaginal discharge. The evidence reviewed primarily focused on updates in the global epidemiology of BV, risk factors for BV, data supportive of sexual transmission of BV-associated bacteria, BV molecular diagnostic tests, and novel treatment regimens. Read More

View Article and Full-Text PDF

Vulvovaginal Candidiasis: A Review of the Evidence for the 2021 Centers for Disease Control and Prevention of Sexually Transmitted Infections Treatment Guidelines.

Clin Infect Dis 2022 Apr;74(Supplement_2):S162-S168

Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA.

Background: Vulvovaginal candidiasis (VVC) is a common cause of vulvovaginal itching and discharge. This article discusses the latest CDC STI Treatment Guidelines for VVC.

Methods: A literature search of relevant topics was performed, and a team of experts was convened to discuss (1) diagnosis/testing modalities; treatment of (2) uncomplicated VVC , (3) complicated VVC, and (4) VVC caused by non-albicans yeast; (5) alternative treatment regimens; (6) susceptibility testing of yeast; Special Populations: (7) pregnancy and (8) HIV and VVC. Read More

View Article and Full-Text PDF

Inflammatory Vulvar Dermatoses (Part I).

Urology 2022 Apr 10. Epub 2022 Apr 10.

Department of Dermatology, University of California, Irvine, CA. Electronic address:

Vulvar disease is common, and urologists are often the first providers to see patients with a vulvar skin condition. Primary vulvar dermatoses can be localized to the anogenital area or a manifestation of more diffuse cutaneous disease. Additionally, secondary dermatoses can develop from exogenous agents and inflammatory vaginitis. Read More

View Article and Full-Text PDF

Ibrexafungerp for the treatment of vulvovaginal candidiasis.

Authors:
Jack D Sobel

Drugs Today (Barc) 2022 Apr;58(4):149-158

Professor of Medicine, Wayne State University School of Medicine, Detroit, Michigan, USA.

Worldwide, effective management of vulvovaginal candidiasis (VVC) continues to serve as a major therapeutic goal with numerous unmet drug treatment challenges. After 3 decades of azole drug dominance, with few recent new antifungal agents and little progress in VVC management, the first-in-class oral triterpenoid glucan synthase inhibitor agent ibrexafungerp has emerged in the treatment of acute VVC. After reviewing existing treatment standards and unmet needs, the pharmacology, pharmacokinetics, antimicrobial activity and clinical efficacy of ibrexafungerp are reviewed in this article together with phase III clinical trial results and drug safety. Read More

View Article and Full-Text PDF

Research Progress on the Correlation Between Typing and Bacterial Vaginosis.

Front Cell Infect Microbiol 2022 25;12:858155. Epub 2022 Mar 25.

Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.

Bacterial vaginosis (BV) is the most common infectious disease of the reproductive tract in women of childbearing age. It often manifests as an imbalance in the vaginal microbiome, including a decrease in and an increase in anaerobic bacteria. While spp. Read More

View Article and Full-Text PDF

Preparation, Antibacterial Potential, and Antibacterial Components of Fermented Compound Chinese Medicine Feed Additives.

Front Vet Sci 2022 24;9:808846. Epub 2022 Mar 24.

Jiangxi Province Key Laboratory of Animal Nutrition/Engineering Research Center of Feed Development, Jiangxi Agricultural University, Nanchang, China.

This experiment was conducted to compare the antibacterial ability and to identify the antibacterial components of different fermented compound Chinese medicine feed additives in order to develop one fermented compound Chinese medicine feed additive product that can effectively alleviate metritis, vaginitis, and mastitis of sows. The Oxford cup method and double dilution method were used to compare the antibacterial ability of three fermented compound Chinese medicine feed additives (A, B, and C). UHPLC-QE-MS-based untargeted metabolomics was used to identify the antibacterial components of fermented compound Chinese medicine feed additives. Read More

View Article and Full-Text PDF

Inadequacies in service delivery for the diagnosis and treatment of vaginitis and vaginosis in Nairobi, Kenya.

Int J STD AIDS 2022 May 5;33(6):584-596. Epub 2022 Apr 5.

569645Radboud University Medical Center, Nijmegen, Netherlands.

Vulvovaginal candidiasis (VVC), a common cause of vaginitis, affects 75% of women in their lifetime. In Kenya, vaginitis/VVC is managed using the vaginal discharge syndrome guidelines. We assessed how frequently healthcare workers consider the diagnosis of vaginitis/VVC in symptomatic women, and adherence to the syndromic guidelines, outpatient records at Nairobi City County health facilities, of non-pregnant symptomatic females aged ≥15 years were abstracted. Read More

View Article and Full-Text PDF

Trichomonase vaginale.

CMAJ 2022 Apr;194(13):E509-E510

Faculté de médecine Max Rady (Cenkowski), Université du Manitoba, Winnipeg, Man.; Division des maladies infectieuses, Département de médecine (Wudel), University of Saskatchewan, Saskatoon, Sask.; Département d'obstétrique, de gynécologie et des sciences de la reproduction (Poliquin), Faculté de médecine Max Rady, Winnipeg, Man.

View Article and Full-Text PDF

Correlation Analysis of Vaginal Microbiome Changes and Bacterial Vaginosis Plus Vulvovaginal Candidiasis Mixed Vaginitis Prognosis.

Front Cell Infect Microbiol 2022 8;12:860589. Epub 2022 Mar 8.

Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.

Mixed vaginitis is the result of the simultaneous presence of different pathogenic processes mediated by at least two types of vaginal pathogens. Among the various types of mixed vaginitis presentations, bacterial vaginosis (BV) plus vulvovaginal candidiasis (VVC) presents to be the most prevalent form. Mixed vaginitis affects the health of women of all ages worldwide. Read More

View Article and Full-Text PDF