13,084 results match your criteria Vaginitis


PRISM study: Comparison of a nystatin-neomycin-polymyxin B combination with miconazole for the empirical treatment of infectious vaginitis.

Med Mal Infect 2019 Feb 18. Epub 2019 Feb 18.

Laboratoire Innotech International, Groupe Innothera, 22, avenue Aristide-Briand, 94110 Arcueil, France.

Objective: An empirical treatment of infectious vaginitis is justified because of its multiple etiologies, the frequent uncertainty of clinical diagnosis and limits of microbiological analysis. Our aim was to comparatively investigate nystatin-neomycin-polymyxin B combination (NNP, Polygynax) and miconazole.

Patients And Methods: In this European multicenter, double-blind PRISM trial, participating women presenting with infectious vaginitis were randomized to receive one vaginal capsule containing either NNP for 12 days or miconazole for 3 days followed by 9 days of placebo. Read More

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http://dx.doi.org/10.1016/j.medmal.2019.01.011DOI Listing
February 2019

The effect of vitamin D and E vaginal suppositories on tamoxifen-induced vaginal atrophy in women with breast cancer.

Support Care Cancer 2019 Feb 7. Epub 2019 Feb 7.

Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: Vaginal atrophy is one of the most common side effects of using tamoxifen in women with breast cancer. Hormone therapy for vaginal atrophy is prohibited in these women. The present study was conducted to investigate the effect of vitamin D and E vaginal suppositories on vaginal atrophy in women with breast cancer receiving tamoxifen. Read More

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http://dx.doi.org/10.1007/s00520-019-04684-6DOI Listing
February 2019
1 Read

A Study of Pap Smears in HIV-Positive and HIV-Negative Women from a Tertiary Care Center in South India.

Acta Cytol 2019 Feb 5:1-6. Epub 2019 Feb 5.

Department of Pathology, Kasturba Medical College, Manipal Academy of Higher Education, Mangalore, India.

Objectives: The aim of this work was to study the spectrum of epithelial abnormalities on Pap smears of HIV-positive women categorized as per the Bethesda System of Reporting Cervical Cytology, to correlate them with CD4 lymphocyte counts, and to compare them with the spectrum of abnormalities seen in a HIV-negative control group. Study Design and Methodology: The present study was a 6-year retrospective study conducted in the Department of Pathology at Kasturba Medical College, Mangalore, which included 150 Pap smears from HIV-positive and HIV-negative women, respectively. The Pap-stained slides of the cases were retrieved and studied. Read More

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http://dx.doi.org/10.1159/000496211DOI Listing
February 2019
4 Reads

Accuracy of the BD MAX™ vaginal panel in the diagnosis of infectious vaginitis.

Eur J Clin Microbiol Infect Dis 2019 Jan 26. Epub 2019 Jan 26.

Servicio de Microbiología, Hospital Universitario de Álava, Instituto de Investigación Biosanitaria, BioAraba, Osakidetza-Servicio Vasco de Salud. c/ Francisco Leandro de Viana, s/n., 01009, Vitoria-Gasteiz, Álava, Spain.

The aim of this study was to evaluate the BD MAX™ vaginal panel in the diagnosis of bacterial vaginosis (BV), vulvovaginal candidiasis (VVC), and trichomoniasis by comparing it with conventional methods: (i) combination of Hay criteria and presence of clue cells with predominant growth of Gardnerella vaginalis, (ii) yeast culture, and (iii) combination of culture, wet mount microscopic examination, and an alternative molecular assay. One thousand vaginal samples of women ≥ 14 years were analyzed; 5% of the samples belonged to pregnant women. 19. Read More

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http://dx.doi.org/10.1007/s10096-019-03480-8DOI Listing
January 2019
2 Reads

Prevalence, antimicrobial susceptibility, serotyping and virulence genes screening of strains at a tertiary care hospital in Tehran, Iran.

Iran J Microbiol 2018 Oct;10(5):307-313

Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Background And Objectives: is the etiological agent of listeriosis, a highly fatal infection which causes miscarriage or stillbirth in pregnant women. The objective of this study was to detect the prevalence, serotypes, antimicrobial susceptibility and virulence factors of isolated from pregnant women with vaginitis at a tertiary care hospital in Tehran, Iran.

Materials And Methods: During September 2015 to February 2017, a total of 400 vaginal swabs were collected from pregnant women. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340003PMC
October 2018
2 Reads

Menopause hormone therapy: latest developments and clinical practice.

Authors:
Tomas Fait

Drugs Context 2019 2;8:212551. Epub 2019 Jan 2.

Department of Obstetrics and Gynecology, Faculty Hospital Motol, 2nd Faculty of Medicine, Charles University, Prague, Czech Republic.

Menopause hormone therapy (MHT) is the most efficient treatment for symptoms of acute climacteric syndrome and for efficient prevention of long-term estrogen deficiency. Vaginal administration of low doses of estrogen is a therapy of choice for treatment and prevention of urogenital atrophy and its consequences. Systemic treatment may include estrogen, but an equally efficient alternative is tibolone. Read More

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http://dx.doi.org/10.7573/dic.212551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317580PMC
January 2019
1 Read

Enhanced antifungal activity of bovine lactoferrin-producing probiotic Lactobacillus casei in the murine model of vulvovaginal candidiasis.

BMC Microbiol 2019 Jan 8;19(1). Epub 2019 Jan 8.

Department of Obstetric & Gynecologic, West China Second University Hospital, Sichuan University, NO. 17.3rd Section, Renmin South Road, Chengdu, Sichuan, 610041, China.

Background: Vulvovaginal candidiasis (VVC) is a common vaginitis caused by Candida species,a frequently recurring condition. Fungal azole-resistant strains with azole-resistance have developed for long and wide explosion to the first-line antifungal azole agent. Bovine lactoferrin (BLF) is a protein from transferrin family secreted by the bovine mammary tissue. Read More

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https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12866-018-1370-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325727PMC
January 2019
9 Reads

The antiviral activity of arbidol hydrochloride against herpes simplex virus type II (HSV-2) in a mouse model of vaginitis.

Int Immunopharmacol 2019 Mar 3;68:58-67. Epub 2019 Jan 3.

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, PR China; Faculty of Chinese Medicine, Macau University of Science and Technology, Taipa, Macau SAR, PR China. Electronic address:

Objective: HSV-2 infection has increased significantly in recent years, which is closely associated with cervical cancer and HIV infection. The lack of success in vaccine development and the emergence of drug resistance to commonly used drugs emphasize the urgent need for alternative antivirals against HSV-2 infection. Arbidol (ARB) has been demonstrated to be a broad spectrum antiviral drug that exhibits immunomodulatory properties that affect the HSV-2 life cycle. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769183074
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http://dx.doi.org/10.1016/j.intimp.2018.09.043DOI Listing
March 2019
10 Reads

Progesterone effects on vaginal cytokines in women with a history of preterm birth.

PLoS One 2018 31;13(12):e0209346. Epub 2018 Dec 31.

Department of Obstetrics & Gynecology and Reproductive Medicine, Stony Brook Medicine, Stony Brook, NY, United States of America.

Objective: To determine the effect of intramuscular progesterone on the vaginal immune response of pregnant women with a history of prior preterm birth.

Methods: A prospective, cohort study of women at 11-16 weeks gestation, ≥18 years of age, and carrying a singleton pregnancy was conducted from June 2016 to August 2017 after IRB approval. Women in the progesterone arm had a history of preterm birth and received weekly intramuscular 17-hydroxyprogesterone caproate. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209346PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312274PMC
December 2018
3 Reads

Vaginosis. Vaginal microbiota.

Enferm Infecc Microbiol Clin 2018 Dec 26. Epub 2018 Dec 26.

Departamento de Biología Funcional, Universidad de Oviedo, Oviedo, España; Fundación de Investigación Oftalmológica, Instituto Oftalmológico Fernández-Vega, Oviedo, España; Fundación para la Investigación y la Innovación Biosanitaria del Principado de Asturias (FINBA), Oviedo, España.

The latest advances in the vaginal microbiome and molecular diagnosis of bacterial vaginosis have allowed for a better knowledge of this entity, characterising aspects of its pathogenesis and the establishment of the vaginal biolayer, the models and new theories of its aetiology, how it is transmitted, with it being considered nowadays as a probable sexually transmitted infection, the separation of other entities such as aerobic vaginosis, its molecular diagnosis and treatment with new molecules to prevent frequent relapses. This entity and the study of the vaginal microbiome have made it possible to consider these infections as a polymicrobial syndrome, putting an end to the dogma: one microorganism, one disease. In addition, a lesser-known entity such as aerobic vaginosis and the methods for its detection are updated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0213005X183038
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http://dx.doi.org/10.1016/j.eimc.2018.11.009DOI Listing
December 2018
4 Reads

Genital ulcers caused by herpes simplex virus.

Enferm Infecc Microbiol Clin 2018 Dec 20. Epub 2018 Dec 20.

Molecular Diagnostics Deparment, Vircell Microbiologists, Parque Tecnológico de la Salud, Granada, España. Electronic address:

Genital herpes is a sexually transmitted disease caused by herpes simplex virus type1 (HSV-1) and type2 (HSV-2) belonging to the alphaherpesvirus family, that includes the varicella zoster virus. HSV infection continues to be the most common cause of vulvar ulcers among the sexually active population. Its incidence increases every year. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0213005X183037
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http://dx.doi.org/10.1016/j.eimc.2018.10.020DOI Listing
December 2018
9 Reads

Bacterial Vaginosis and Desquamative Inflammatory Vaginitis.

N Engl J Med 2018 12;379(23):2246-2254

From the Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki (J.P.); and the Department of Medicine, University of British Columbia, Vancouver, Canada (R.C.B.).

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http://www.nejm.org/doi/10.1056/NEJMra1808418
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http://dx.doi.org/10.1056/NEJMra1808418DOI Listing
December 2018
9 Reads

Protective Effects of cis-2-Dodecenoic Acid in an Experimental Mouse Model of Vaginal Candidiasis.

Biomed Environ Sci 2018 Nov;31(11):816-828

Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing 210023, Jiangsu, China.

Objective: To evaluate the efficacy of cis-2-dodecenoic acid (BDSF) in the treatment and prevention of vaginal candidiasis in vivo.

Methods: The activities of different concentrations of BDSF against the virulence factors of Candida albicans (C. albicans) were determined in vitro. Read More

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http://www.besjournal.com/Articles/Archive/2018/No11/201812/
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http://dx.doi.org/10.3967/bes2018.109DOI Listing
November 2018
8 Reads

Chitosan-hydroxypropyl methylcellulose tioconazole films: A promising alternative dosage form for the treatment of vaginal candidiasis.

Int J Pharm 2019 Feb 12;556:181-191. Epub 2018 Dec 12.

Instituto de Química Rosario (IQUIR, CONICET-UNR), Suipacha 531, Rosario S2002LRK, Argentina; Área Técnica Farmacéutica, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, Rosario S2002LRK, Argentina. Electronic address:

Vaginal candidiasis is considered a frequent opportunistic mucosal infection and the second most common cause of vaginitis after bacterial vaginosis. In this work, different vaginal films based on chitosan, hydroxypropyl methylcellulose and blends of these polymers containing tioconazole, were developed and thoroughly characterized to improve the conventional therapeutics of vaginal candidiasis. Mechanical properties, swelling, adhesiveness, morphology, antifungal activity, hemocompatibility and cytotoxicity were evaluated. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03785173183091
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http://dx.doi.org/10.1016/j.ijpharm.2018.12.011DOI Listing
February 2019
14 Reads

A performance evaluation of an immuno-latex chromatography card for the rapid detection of Candida spp.

J Microbiol Methods 2019 Feb 10;157:4-8. Epub 2018 Dec 10.

Department of Clinical Laboratory, the First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, China.

This report evaluates the performance and species specificity of an immuno-latex chromatography card (ICC) for rapid detection of Candida spp. Double-manipulator single-blind Gram staining smear examination (GSSE) and ICC were used to analyze 354 vaginal discharge specimens (VDS) (including 98 tested as positive by GSSE) from women with suspected candidal vaginitis, simulated specimens with a concentration gradient, and vaginitis causing organism suspensions (0.9% NaCl) of 22 species from nine genera. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01677012183045
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http://dx.doi.org/10.1016/j.mimet.2018.12.005DOI Listing
February 2019
4 Reads

Influence of Nursing Intervention on Recurrent Vulvovaginal Candidiasis Patients Treated with ATP-infrared Bio-effect Technique.

Authors:
Wenxiang Li

Iran J Public Health 2018 Oct;47(10):1511-1519

Dept. of Gynecology, Women & Children's Health Care Hospital of Linyi, Linyi, China.

Background: We aimed to investigate the influence of nursing intervention on recurrent vulvovaginal candidiasis (RVVC) patients treated with adenosine triphosphate (ATP)-infrared bio-effect technique.

Methods: Sixty eight RVVC patients of Women & Children's Health Care Hospital of Linyi were randomly divided into intervention group (n=34) and control group (n=34) from to June, 2016 to June 2017. Patients in intervention group received the one-to-one intervention based on ATP-infrared bio-effect technique; the individualized nursing intervention program was developed. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277732PMC
October 2018
1 Read

Spectrum of parasitic infections in centrifuged urine sediments from a newly developed tertiary care centre in Central India.

J Parasit Dis 2018 Dec 29;42(4):608-615. Epub 2018 Oct 29.

3Department of Microbiology, All India Institute of Medical Sciences, Saket Nagar, Bhopal, MP 462024 India.

Detection of urinary parasites is relatively rare and incidental finding in routine urine examination. Common urinary parasitic infections as described in literature include Trichomonas, and Microfilaria. is known to cause vaginitis and urethritis, and may be found in urine sediments. Read More

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http://dx.doi.org/10.1007/s12639-018-1043-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261132PMC
December 2018
16 Reads

Genital Tract Pathology in Female Pet Guinea Pigs (Cavia porcellus): a Retrospective Study of 655 Post-mortem and 64 Biopsy Cases.

J Comp Pathol 2018 Nov 19;165:13-22. Epub 2018 Oct 19.

Institute of Veterinary Pathology, Freie Universität Berlin, Robert-von-Ostertagstrase 15, Germany. Electronic address:

Disorders of the female genital tract are among the most common disorders in pet guinea pigs (Cavia porcellus); however, knowledge of many aspects of these disorders is sparse, especially regarding their incidence and age distribution. Ovarian cysts, as the most common genital tract disorder in guinea pigs, have been investigated in detail; however, information on the nature of these cysts is inconsistent. The present study reviewed genital tract disorders occurring within 655 full post-mortem examinations of intact female pet guinea pigs and 64 female genital tract biopsies examined over a 22. Read More

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http://dx.doi.org/10.1016/j.jcpa.2018.09.001DOI Listing
November 2018
1 Read

Intravaginal Device-Type and Treatment-Length for Ovine Estrus Synchronization Modify Vaginal Mucus and Microbiota and Affect Fertility.

Animals (Basel) 2018 Nov 29;8(12). Epub 2018 Nov 29.

Dpto. de Reproduccion Animal, INIA, Avda. Puerta de Hierro s/n., 28040 Madrid, Spain.

Induction and synchronization of estrus and ovulation in sheep is based on intravaginal progestagen-impregnated polyurethane sponges or progesterone-loaded silicon-based devices (CIDR), in either short- (6⁻7 days) or long-term (12⁻14 days) protocols. Bearing in mind that the use of intravaginal sponges in long-term protocols has been related to the presence of vaginitis at removal, we compared the effects of sponges and CIDRs, maintained during either 7 or 14 days, on vaginal features (characteristics of vaginal mucus discharge, pH and microbiota) and fertility under field conditions. Almost all the ewes treated with intravaginal sponges showed vaginal discharge at device withdrawal, which was purulent and/or bloody in around 15% and 80% of the females treated for 7 and 14 days, respectively. Read More

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http://dx.doi.org/10.3390/ani8120226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6316288PMC
November 2018
1 Read

Intralesional and subcutaneous application of Viscum album L. (European mistletoe) extract in cervical carcinoma in situ: A CARE compliant case report.

Medicine (Baltimore) 2018 Nov;97(48):e13420

Institute for Applied Epistemology and Medical Methodology at the University of Witten/Herdecke.

Rationale: Carcinoma in situ (CIS) of the uterine cervix is a premalignant condition of squamous epithelium. The standard treatments are excision and ablation procedures; for women with positive margins, hysterectomy is recommended.

Patient Concerns: A 47-year-old Peruvian woman with recurrent candidal vaginitis had been diagnosed with colpocervicitis and squamous metaplasia 8 years ago, which were not treated. Read More

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http://dx.doi.org/10.1097/MD.0000000000013420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283068PMC
November 2018
1 Read

Anti-Inflammatory Effect of Surfactant Lipid in the Vaginal Mucosa: A Pilot Study.

J Low Genit Tract Dis 2019 Jan;23(1):71-74

Department of Obstetrics & Gynecology, Pennsylvania State University College of Medicine, Hershey, PA.

Objective: The aim of the study was to test the hypothesis that vaginal administration of surfactant lipids, which may counter-balance the proinflammatory effects of vaginal surfactant protein A, will decrease proinflammatory cytokines and increase anti-inflammatory cytokines in vaginal mucosal fluid in healthy women.

Materials And Methods: Three groups of healthy cycling women were randomized to receive vaginally a single dose of the following: (1) low-dose calfactant, a type of surfactant lipids, 0.8 mg/ml; (2) high-dose calfactant 8. Read More

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http://dx.doi.org/10.1097/LGT.0000000000000448DOI Listing
January 2019
1 Read

Device-based treatment for vaginal wellness.

Semin Cutan Med Surg 2018 Dec;37(4):226-232

Yale University School of Medicine, New Haven, Connecticut, USA.

Genitourinary syndrome of menopause (GSM), encompassing the disorders of atrophic vaginitis, urinary incontinence, and pelvic prolapse, affects the majority of postmenopausal women, as well as patients who are undergoing breast cancer treatement, post-ovarectomy, post-radiation, and breast-feeding. There is a need for better treatment options for these common conditions that adversely affect physical function and quality of life and that are often underserved by existing options. Lasers have been used to treat genitourinary tissue for over 40 years, and over the past decade, several lasers and radiofrequency devices have been developed and clinically tested for the treatment of GSM, with an accumulating body of evidence demonstrating their safety and efficacy. Read More

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https://scmsjournal.com/article/buy_now/?id=797
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http://dx.doi.org/10.12788/j.sder.2018.052DOI Listing
December 2018
18 Reads

Aerobic vaginitis in late pregnancy and outcomes of pregnancy.

Eur J Clin Microbiol Infect Dis 2019 Feb 22;38(2):233-239. Epub 2018 Nov 22.

Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, No.154 Anshan Road, Heping District, Tianjin, 300052, China.

The purpose of this study was to investigate the risk factors and pregnancy outcomes for aerobic vaginitis (AV) in late pregnancy. A total of 624 pregnant women who were treated in the perinatal unit at Tianjin Medical University General Hospital and 365 nonpregnant women who were evaluated at a health management center from January 2015 to June 2016 were recruited for this case-control study. A questionnaire covering personal hygiene habits and sociodemographic factors was administered to pregnant women to analyze risk factors for AV. Read More

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http://dx.doi.org/10.1007/s10096-018-3416-2DOI Listing
February 2019
15 Reads

Calophyllum inophyllum in vaginitis treatment: Stimulated by electroporation with an in vitro approach.

Adv Clin Exp Med 2018 Nov 22. Epub 2018 Nov 22.

Department of Molecular and Cellular Biology, Faculty of Pharmacy with Division of Laboratory Diagnostics, Wroclaw Medical University, Poland.

Background: Vaginitis is one of the most common problems in clinical medicine and is cited most often during visits to obstetricians and gynecologists. Most of the inflammation cases are caused by candidiasis trichomoniasis and bacterial vaginosis. Therefore, treatment of vaginal infections must use antibiotic or antifungal drugs, which often provide quick relief to the patient. Read More

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http://dx.doi.org/10.17219/acem/87045DOI Listing
November 2018
12 Reads

Application of conjugated estrogen cream in the treatment of postmenopausal atrophic vaginitis.

Pak J Pharm Sci 2018 Sep;31(5(Special)):2283-2286

Obstetrics and Gynecology Department, Beijing Shijitan Hospital Affiliated to Capital Medical University, Beijing, China.

To observe and analyze the effect of conjugated estrogen cream in the treatment of postmenopausal atrophic vaginitis. The 160 patients clearly diagnosed with postmenopausal atrophic vaginitis and treated in our hospital were selected as subjects and divided into study group and reference group with equal number of cases. The reference group was treated with compound metronidazole suppository, while the study group was treated with conjugated estrogen cream. Read More

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September 2018
13 Reads

[Interaction between vaginal micro-environment alterations and HPV16 infection in cervical intraepithelial neoplasia].

Zhonghua Liu Xing Bing Xue Za Zhi 2018 Nov;39(11):1486-1490

Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China.

To explore the effect of vaginal micro-environment alterations and HPV16 infection and their interaction in the progression of cervical intraepithelial neoplasia. The participants of this study came from the cervical lesions study cohort in Shanxi province, including 623 women with normal cervical (NC), 303 patients with pathogenically diagnosed low-grade cervical intraepithelial neoplasia (CINⅠ) and 93 patients with pathogenically diagnosed high-grade cervical intraepithelial neoplasia (CINⅡ/Ⅲ). The data of the demographic characteristics of the study subjects and factors related to cervical intraepithelial neoplasia were collected, and HPV16 infection were detected by using flow-through hybridization technology and H(2)O(2), β-glucuronidase, clotting enzyme, neuraminidase and leucocyte esterase in vaginal secretions were detected by using the combined detection kit of aerobic vaginitis and bacterial vaginosis. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2018.11.013DOI Listing
November 2018
10 Reads

Bacterial vaginosis: a primer for clinicians.

Postgrad Med 2019 Jan 30;131(1):8-18. Epub 2018 Nov 30.

b Center for Pelvic Medicine, LLC , Rosemont , PA , USA.

Bacterial vaginosis (BV) affects approximately one third of women in the United States. While often asymptomatic, BV infection may be accompanied by serious health consequences, such as preterm birth and pelvic inflammatory disease, and may facilitate acquisition of sexually transmitted infections. Identifying appropriate patients for screening, such as pregnant women, women planning pregnancy, and women with multiple and/or new sexual partners, is imperative for treatment. Read More

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https://www.tandfonline.com/doi/full/10.1080/00325481.2019.1
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http://dx.doi.org/10.1080/00325481.2019.1546534DOI Listing
January 2019
16 Reads
1.537 Impact Factor

Localized Provoked Vulvodynia: Association With Nerve Growth Factor and Transient Receptor Potential Vanilloid Type 1 Genes Polymorphisms.

J Low Genit Tract Dis 2019 Jan;23(1):58-64

Department of Obstetrics & Gynecology, Galilee Medical Center, Nahariya, Israel.

Objective: The aim of the study was to study the associations between localized provoked vulvodynia (LPV) and several single-nucleotide polymorphisms (SNPs) in the transient receptor potential vanilloid type 1 (TRPV1), nerve growth factor (NGF), and the heparanase (HPSE) genes.

Materials And Methods: Prevalence of SNPs among 65 women with moderate or severe primary LPV (initial symptoms occur with first provoking physical contact) and 126 healthy, ethnically matched controls was analyzed in an observational case-control study. Each participant answered a questionnaire addressing familial LPV occurrence and comorbid pain conditions. Read More

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http://dx.doi.org/10.1097/LGT.0000000000000445DOI Listing
January 2019
9 Reads

Randomized, Double-Blind, Placebo-Controlled Study of Modified Erzhi Granules in the Treatment of Menopause-Related Vulvovaginal Atrophy.

Evid Based Complement Alternat Med 2018 14;2018:6452709. Epub 2018 Oct 14.

Tianjin University of Traditional Chinese Medicine, China.

Objective: To evaluate the clinical therapeutic efficacy and safety of modified Erzhi granules (MEG) in patients with menopause-related vulvovaginal atrophy (VVA).

Methods: This randomized, double-blind, placebo-controlled study comprised two groups, including the treatment and control groups. Patients receive MEG and placebo for 12 weeks, respectively. Read More

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https://www.hindawi.com/journals/ecam/2018/6452709/
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http://dx.doi.org/10.1155/2018/6452709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204235PMC
October 2018
11 Reads
1.880 Impact Factor

Genitourinary Changes with Aging.

Obstet Gynecol Clin North Am 2018 Dec 25;45(4):737-750. Epub 2018 Oct 25.

Department of Obstetrics and Gynecology, University of California, Davis, 4860 Y Street, Suite 2500, Sacramento, CA 95817, USA. Electronic address:

Both chronologic aging and menopause affect the physical, physiologic, and microbiological characteristics of the genitourinary tract. The genitourinary syndrome of menopause, characterized by vulvovaginal and lower urinary tract signs and symptoms, is prevalent and has a significant negative impact on women's lives. In this article, the authors detail the genitourinary tract changes associated with menopause and/or aging. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08898545183007
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http://dx.doi.org/10.1016/j.ogc.2018.07.010DOI Listing
December 2018
17 Reads

Transvaginal natural orifice transluminal endoscopic surgery in the diagnosis of ascites of unknown origin.

Gastrointest Endosc 2018 Nov 1. Epub 2018 Nov 1.

Department of Gastroenterology and Hepatology, the General Hospital of the Chinese People's Liberation Army, Beijing, China.

Background And Aims: Natural orifice transluminal endoscopic surgery (NOTES) has been established in animal models and human studies, but few clinical studies have investigated transvaginal NOTES in the diagnosis of unexplained refractory ascites. We aimed to assess the feasibility, efficacy, and safety of transvaginal NOTES for the diagnosis of unexplained ascites in female patients.

Methods: A prospective study was done involving 3 female patients with unexplained ascites. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00165107183324
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http://dx.doi.org/10.1016/j.gie.2018.09.047DOI Listing
November 2018
10 Reads

An Update on the Roles of Non- Species in Vulvovaginitis.

J Fungi (Basel) 2018 Oct 31;4(4). Epub 2018 Oct 31.

Department of Medical Microbiology and Parasitology, University of Ibadan, Ibadan 200284, Nigeria.

species are one of the commonest causes of vaginitis in healthy women of reproductive age. Vulvovaginal candidiasis (VVC) is characterized by vulvovaginal itching, redness and discharge. , which is a common genito-urinary tract commensal, has been the prominent species and remains the most common fungal agent isolated from clinical samples of patients diagnosed with VVC. Read More

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http://dx.doi.org/10.3390/jof4040121DOI Listing
October 2018
3 Reads

The human microbiome: implications for health and disease, including HIV infection.

Top Antivir Med 2018 Sep;26(3):75-78

University of California San Diego, La Jolla, CA, USA.

Our increased understanding of the human microbiome has brought insight into the role it plays in health and disease, including HIV infection. Studies have shown that the gut microbiome is less diverse in individuals with HIV infection than in noninfected control subjects. Efforts to modify the microbiome to bolster immune reconstitution in people with HIV infection have so far been unsuccessful. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291299PMC
September 2018
3 Reads

Longitudinal association of gonorrhea and bacterial vaginosis with repeat chlamydia diagnoses among U.S. Army women: a retrospective cohort analysis.

Mil Med Res 2018 10 30;5(1):37. Epub 2018 Oct 30.

Armed Forces Health Surveillance Branch, Public Health Division, Defense Health Agency, Silver Spring, MD, USA.

Background: Historically, sexually transmitted infections have affected the health of the U.S. military. Read More

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https://mmrjournal.biomedcentral.com/articles/10.1186/s40779
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http://dx.doi.org/10.1186/s40779-018-0184-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206713PMC
October 2018
8 Reads

Adhesion and biofilm formation of Candida parapsilosis isolated from vaginal secretions to copper intrauterine devices.

Rev Inst Med Trop Sao Paulo 2018 Oct 22;60:e59. Epub 2018 Oct 22.

Universidade Federal do Maranhão, Programa de Pós-Graduação em Saúde do Adulto, São Luís, Maranhão, Brazil.

Introduction: Candida parapsilosis is one of the main species that is able to adhere to forming biofilms on inert materials. Adhesion is the first step towards the colonization and invasion of host cells during the infectious process. Among the infections, vulvovaginal candidiasis is increasingly common. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/S1678-9946201860059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199129PMC
October 2018
10 Reads
0.910 Impact Factor

Association between the vaginal microbiota, menopause status, and signs of vulvovaginal atrophy.

Menopause 2018 Nov;25(11):1321-1330

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.

Objective: The vaginal microbiota helps protect the female genital tract from disease. We sought to describe the composition of the vaginal microbiota in premenopausal, perimenopausal, and postmenopausal women and to explore the association between the microbiota and vulvovaginal atrophy (VVA).

Methods: Eighty-seven women (aged 35-60 y) were classified as premenopausal (n = 30), perimenopausal (n = 29), or postmenopausal (n = 28) according to Stages of Reproductive Aging Workshop guidelines. Read More

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http://Insights.ovid.com/crossref?an=00042192-201811000-0002
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http://dx.doi.org/10.1097/GME.0000000000001236DOI Listing
November 2018
7 Reads

17β-estradiol vaginal tablet versus conjugated equine estrogen vaginal cream to relieve menopausal atrophic vaginitis.

Menopause 2018 Nov;25(11):1208-1213

Oshawa Clinic, Oshawa, Ontario, Canada.

Objectives: The efficacy and safety of 25-μg 17β-estradiol vaginal tablets (Vagifem) were assessed and compared with 1.25-mg conjugated equine estrogen vaginal cream (Premarin Vaginal Cream) for the relief of menopausal-derived atrophic vaginitis, resulting from estrogen deficiency.

Design: In a multicenter, open-label, randomized, parallel-group study, 159 menopausal women were treated for 24 weeks with either vaginal tablets or vaginal cream. Read More

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http://Insights.ovid.com/crossref?an=00042192-201811000-0000
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http://dx.doi.org/10.1097/GME.0000000000001220DOI Listing
November 2018
9 Reads

Inhibition of CXCR4 by MicroRNA-1192 Reduces the Activation of Th17 Cells and Expression of Inflammation Factors in a Mouse Model of Vulvovaginal Candidiasis.

Cell Physiol Biochem 2018 24;50(3):893-910. Epub 2018 Oct 24.

Department of Obstetrics and Gynecology, Linyi People's Hospital, Linyi, China.

Background/aims: Vulvovaginal candidiasis (VVC) is a disease commonly occurring in sexually active women. The involvement of microRNAs in several kinds of infectious diseases has been highlighted in a number of researches. Therefore, we conducted the present study in order to investigate whether microRNA-1192 (miR-1192) would significantly target CXCR4 in Th17 cells as well as inflammatory factors in mouse models suffering from VVC. Read More

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https://www.karger.com/Article/FullText/494475
Publisher Site
http://dx.doi.org/10.1159/000494475DOI Listing
November 2018
5 Reads
2.880 Impact Factor

Prevalence of Ureaplasma spp. and Mycoplasma hominis in healthy women and patients with flora alterations.

Diagn Microbiol Infect Dis 2019 Mar 4;93(3):227-231. Epub 2018 Oct 4.

Femicare Clinical Research for Women, 3300, Gasthuismolenstraat 31, Tienen, Belgium; Department of Obstetrics and Gynecology, Antwerp University, 2000, Prinsstraat 13, Antwerp, Belgium.

The objective was to estimate the prevalence of Mycoplasma hominis, Ureaplasma parvum, and Ureaplasma urealyticum in healthy women and patients with altered vaginal microflora. Vaginal samples from 2594 unselected female patients were divided into normal, bacterial vaginosis (BV), and aerobic vaginitis (AV) groups and tested for U. parvum, U. Read More

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http://dx.doi.org/10.1016/j.diagmicrobio.2018.10.001DOI Listing
March 2019
3 Reads

Treatment of bacterial vaginosis to prevent preterm birth.

Lancet 2018 11 12;392(10160):2141-2142. Epub 2018 Oct 12.

Department of Epidemiology and Public Health, Institute for Genome Sciences, The University of Maryland School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1016/S0140-6736(18)32115-9DOI Listing
November 2018
2 Reads

Early clindamycin for bacterial vaginosis in pregnancy (PREMEVA): a multicentre, double-blind, randomised controlled trial.

Lancet 2018 11 12;392(10160):2171-2179. Epub 2018 Oct 12.

Institut de Microbiologie, Centre Hospitalier Universitaire de Lille, Lille, France; Recherche Translationelle Relation Hôte-Pathogènes, Université de Lille, Lille, France. Electronic address:

Background: Preterm delivery during pregnancy (<37 weeks' gestation) is a leading cause of perinatal mortality and morbidity. Treating bacterial vaginosis during pregnancy can reduce poor outcomes, such as preterm birth. We aimed to investigate whether treatment of bacterial vaginosis decreases late miscarriages or spontaneous very preterm birth. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01406736183161
Publisher Site
http://dx.doi.org/10.1016/S0140-6736(18)31617-9DOI Listing
November 2018
16 Reads

[La ménopause et le traitement hormonal de la ménopause : une actualisation].

Rev Med Brux 2018;39(4):259-263

Service de Gynécologie-Obstétrique, CHU Saint-Pierre, ULB.

Postmenopausal hormone therapy (MHT) is mainly used for the relief of menopausal symptoms. It can also be prescribed for the treatment of postmenopausal osteoporosis, but nowadays, other medications are given to older patients for this indication. Current, available data, demonstrates that MHT is beneficial as well as safe for postmenopausal, symptomatic women. Read More

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December 2018
2 Reads

Chemical Components and Biological Activities of the Genus : A Review of the Recent Literature.

Molecules 2018 Oct 8;23(10). Epub 2018 Oct 8.

Jiangxi Key Laboratory for Postharvest Technology and Nondestructive Testing of Fruits & Vegetables, Collaborative Innovation Center of Post-Harvest Key Technology and Quality Safety of Fruits and Vegetables, College of Agronomy, Jiangxi Agricultural University, Nanchang 330045, China.

Medicinal plants have served humans since prehistoric times to treat various ailments. Both developed and underdeveloped countries rely on traditional systems of medication using natural sources from plants. is one of the largest genus in the family Phyllanthaceae, comprising over 700 well known species cosmopolitan in distribution mainly in the tropics and subtropics. Read More

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http://www.mdpi.com/1420-3049/23/10/2567
Publisher Site
http://dx.doi.org/10.3390/molecules23102567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6222918PMC
October 2018
5 Reads

Associations of birth characteristics with perimenopausal disorders: a prospective cohort study.

J Dev Orig Health Dis 2018 Oct 9:1-7. Epub 2018 Oct 9.

1Department of Public Health Sciences,Karolinska Institutet,Stockholm,Sweden.

Perimenopausal disorders (PDs) are prevalent and importantly affect quality of life among middle-aged women. Yet, very little is known about the developmental origins of these disorders. The objective of this study was to investigate the associations of birth characteristics with PDs. Read More

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http://dx.doi.org/10.1017/S204017441800065XDOI Listing
October 2018
2 Reads

Is multiple-site colonization with Candida spp. related to inadequate response to individualized fluconazole maintenance therapy in women with recurrent Candida vulvovaginitis?

Diagn Microbiol Infect Dis 2018 Nov 2;92(3):226-229. Epub 2018 Jun 2.

Femicare vzw, Tienen.

Objective: Although most women on fluconazole maintenance therapy for recurrent vulvovaginal candidosis experience a substantial improvement in quality of life, some do not respond to therapy. Is candidal colonization of extragenital sites related to suboptimal response to maintenance therapy?

Patients And Methods: Women included in a multicenter follow-up study (ReCiDiF) were evaluated for clinical signs and presence of yeasts in nose, mouth, anus, perineum, and urine. Candida was diagnosed by positive microscopy, confirmed by positive culture or polymerase chain reaction. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07328893183018
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http://dx.doi.org/10.1016/j.diagmicrobio.2018.05.024DOI Listing
November 2018
4 Reads

A high burden of asymptomatic genital tract infections undermines the syndromic management approach among adolescents and young adults in South Africa: implications for HIV prevention efforts.

BMC Infect Dis 2018 Oct 3;18(1):499. Epub 2018 Oct 3.

Perinatal HIV Research Unit (PHRU), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Background: Youth in southern Africa, particularly adolescent girls and young women, are a key population for HIV prevention interventions. Untreated genital tract infections (GTIs) increase both HIV transmission and acquisition risks. South African GTI treatment guidelines employ syndromic management, which relies on individuals to report GTI signs and symptoms. Read More

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http://dx.doi.org/10.1186/s12879-018-3380-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6171143PMC
October 2018
3 Reads

Natural Products for Vulvovaginal Candidiasis Treatment: Evidence from Clinical Trials.

Curr Top Med Chem 2018 ;18(15):1324-1332

Department of Pharmacology, Faculty of Pharmacy, Universidad Complutense de Madrid. Plaza Ramon y Cajal s/n, Ciudad Universitaria, 28040, Madrid, Spain.

Background: Candida albicans is an opportunistic yeast that causes more than 90% of all vulvovaginal infections. Because of being inherently resistant to antifungals drugs such as azole derivatives, the search for anti-Candida albicans agents with new pharmacological targets is considered as the main therapeutic strategy to prevent and treat these types of infections. In this context, products of natural origin are a promising source of compounds with antifungal activity. Read More

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http://dx.doi.org/10.2174/1568026618666181002111341DOI Listing
February 2019
2 Reads

Alternative and complementary therapies for vulvovaginal candidiasis.

Folia Microbiol (Praha) 2019 Mar 30;64(2):133-141. Epub 2018 Sep 30.

Postgraduate Program in Health Sciences, Faculty of Medicine and Clinical Analysis Technical Course, Health Technical School, Federal University of Uberlandia, Uberlandia, Minas Gerais, Brazil.

When it comes to women's health, treating vaginal infections makes up a high proportion of the gynecological services. Among the forms of vaginitis, vulvovaginal candidiasis (VVC) is considered the second most common. Demand for new treatment alternatives is increasingly relevant, especially for therapies with fewer side effects, better tolerability, and lower cost, while still offering improved quality of life in terms of disease prevention. Read More

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http://dx.doi.org/10.1007/s12223-018-0652-xDOI Listing
March 2019
4 Reads