13,025 results match your criteria Vaginitis


A performance evaluation of an immuno-latex chromatography card for the rapid detection of Candida spp.

J Microbiol Methods 2018 Dec 10. Epub 2018 Dec 10.

Department of Clinical Laboratory, the First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, China.

This report evaluates the performance and species specificity of an immuno-latex chromatography card (ICC) for rapid detection of Candida spp. Double-manipulator single-blind Gram staining smear examination (GSSE) and ICC were used to analyze 354 vaginal discharge specimens (VDS) (including 98 tested as positive by GSSE) from women with suspected candidal vaginitis, simulated specimens with a concentration gradient, and vaginitis causing organism suspensions (0.9% NaCl) of 22 species from nine genera. Read More

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December 2018

Influence of Nursing Intervention on Recurrent Vulvovaginal Candidiasis Patients Treated with ATP-infrared Bio-effect Technique.

Authors:
Wenxiang Li

Iran J Public Health 2018 Oct;47(10):1511-1519

Dept. of Gynecology, Women & Children's Health Care Hospital of Linyi, Linyi, China.

Background: We aimed to investigate the influence of nursing intervention on recurrent vulvovaginal candidiasis (RVVC) patients treated with adenosine triphosphate (ATP)-infrared bio-effect technique.

Methods: Sixty eight RVVC patients of Women & Children's Health Care Hospital of Linyi were randomly divided into intervention group (n=34) and control group (n=34) from to June, 2016 to June 2017. Patients in intervention group received the one-to-one intervention based on ATP-infrared bio-effect technique; the individualized nursing intervention program was developed. Read More

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October 2018

Spectrum of parasitic infections in centrifuged urine sediments from a newly developed tertiary care centre in Central India.

J Parasit Dis 2018 Dec 29;42(4):608-615. Epub 2018 Oct 29.

3Department of Microbiology, All India Institute of Medical Sciences, Saket Nagar, Bhopal, MP 462024 India.

Detection of urinary parasites is relatively rare and incidental finding in routine urine examination. Common urinary parasitic infections as described in literature include Trichomonas, and Microfilaria. is known to cause vaginitis and urethritis, and may be found in urine sediments. Read More

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December 2018

Genital Tract Pathology in Female Pet Guinea Pigs (Cavia porcellus): a Retrospective Study of 655 Post-mortem and 64 Biopsy Cases.

J Comp Pathol 2018 Nov 19;165:13-22. Epub 2018 Oct 19.

Institute of Veterinary Pathology, Freie Universität Berlin, Robert-von-Ostertagstrase 15, Germany. Electronic address:

Disorders of the female genital tract are among the most common disorders in pet guinea pigs (Cavia porcellus); however, knowledge of many aspects of these disorders is sparse, especially regarding their incidence and age distribution. Ovarian cysts, as the most common genital tract disorder in guinea pigs, have been investigated in detail; however, information on the nature of these cysts is inconsistent. The present study reviewed genital tract disorders occurring within 655 full post-mortem examinations of intact female pet guinea pigs and 64 female genital tract biopsies examined over a 22. Read More

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November 2018
1 Read

Intravaginal Device-Type and Treatment-Length for Ovine Estrus Synchronization Modify Vaginal Mucus and Microbiota and Affect Fertility.

Animals (Basel) 2018 Nov 29;8(12). Epub 2018 Nov 29.

Dpto. de Reproduccion Animal, INIA, Avda. Puerta de Hierro s/n., 28040 Madrid, Spain.

Induction and synchronization of estrus and ovulation in sheep is based on intravaginal progestagen-impregnated polyurethane sponges or progesterone-loaded silicon-based devices (CIDR), in either short- (6⁻7 days) or long-term (12⁻14 days) protocols. Bearing in mind that the use of intravaginal sponges in long-term protocols has been related to the presence of vaginitis at removal, we compared the effects of sponges and CIDRs, maintained during either 7 or 14 days, on vaginal features (characteristics of vaginal mucus discharge, pH and microbiota) and fertility under field conditions. Almost all the ewes treated with intravaginal sponges showed vaginal discharge at device withdrawal, which was purulent and/or bloody in around 15% and 80% of the females treated for 7 and 14 days, respectively. Read More

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November 2018
1 Read

Intralesional and subcutaneous application of Viscum album L. (European mistletoe) extract in cervical carcinoma in situ: A CARE compliant case report.

Medicine (Baltimore) 2018 Nov;97(48):e13420

Institute for Applied Epistemology and Medical Methodology at the University of Witten/Herdecke.

Rationale: Carcinoma in situ (CIS) of the uterine cervix is a premalignant condition of squamous epithelium. The standard treatments are excision and ablation procedures; for women with positive margins, hysterectomy is recommended.

Patient Concerns: A 47-year-old Peruvian woman with recurrent candidal vaginitis had been diagnosed with colpocervicitis and squamous metaplasia 8 years ago, which were not treated. Read More

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November 2018
1 Read

Anti-Inflammatory Effect of Surfactant Lipid in the Vaginal Mucosa: A Pilot Study.

J Low Genit Tract Dis 2018 Nov 27. Epub 2018 Nov 27.

Department of Obstetrics & Gynecology, Pennsylvania State University College ofMedicine, Hershey, PA.

Objective: The aim of the study was to test the hypothesis that vaginal administration of surfactant lipids, which may counter-balance the proinflammatory effects of vaginal surfactant protein A, will decrease proinflammatory cytokines and increase anti-inflammatory cytokines in vaginal mucosal fluid in healthy women.

Materials And Methods: Three groups of healthy cycling women were randomized to receive vaginally a single dose of the following: (1) low-dose calfactant, a type of surfactant lipids, 0.8 mg/ml; (2) high-dose calfactant 8. Read More

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November 2018

Device-based treatment for vaginal wellness.

Semin Cutan Med Surg 2018 Dec;37(4):226-232

Yale University School of Medicine, New Haven, Connecticut, USA.

Genitourinary syndrome of menopause (GSM), encompassing the disorders of atrophic vaginitis, urinary incontinence, and pelvic prolapse, affects the majority of postmenopausal women, as well as patients who are undergoing breast cancer treatement, post-ovarectomy, post-radiation, and breast-feeding. There is a need for better treatment options for these common conditions that adversely affect physical function and quality of life and that are often underserved by existing options. Lasers have been used to treat genitourinary tissue for over 40 years, and over the past decade, several lasers and radiofrequency devices have been developed and clinically tested for the treatment of GSM, with an accumulating body of evidence demonstrating their safety and efficacy. Read More

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December 2018
3 Reads

Aerobic vaginitis in late pregnancy and outcomes of pregnancy.

Eur J Clin Microbiol Infect Dis 2018 Nov 22. Epub 2018 Nov 22.

Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, No.154 Anshan Road, Heping District, Tianjin, 300052, China.

The purpose of this study was to investigate the risk factors and pregnancy outcomes for aerobic vaginitis (AV) in late pregnancy. A total of 624 pregnant women who were treated in the perinatal unit at Tianjin Medical University General Hospital and 365 nonpregnant women who were evaluated at a health management center from January 2015 to June 2016 were recruited for this case-control study. A questionnaire covering personal hygiene habits and sociodemographic factors was administered to pregnant women to analyze risk factors for AV. Read More

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November 2018
8 Reads

Calophyllum inophyllum in vaginitis treatment: Stimulated by electroporation with an in vitro approach.

Adv Clin Exp Med 2018 Nov 22. Epub 2018 Nov 22.

Department of Molecular and Cellular Biology, Faculty of Pharmacy with Division of Laboratory Diagnostics, Wroclaw Medical University, Poland.

Background: Vaginitis is one of the most common problems in clinical medicine and is cited most often during visits to obstetricians and gynecologists. Most of the inflammation cases are caused by candidiasis trichomoniasis and bacterial vaginosis. Therefore, treatment of vaginal infections must use antibiotic or antifungal drugs, which often provide quick relief to the patient. Read More

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November 2018
3 Reads

Application of conjugated estrogen cream in the treatment of postmenopausal atrophic vaginitis.

Pak J Pharm Sci 2018 Sep;31(5(Special)):2283-2286

Obstetrics and Gynecology Department, Beijing Shijitan Hospital Affiliated to Capital Medical University, Beijing, China.

To observe and analyze the effect of conjugated estrogen cream in the treatment of postmenopausal atrophic vaginitis. The 160 patients clearly diagnosed with postmenopausal atrophic vaginitis and treated in our hospital were selected as subjects and divided into study group and reference group with equal number of cases. The reference group was treated with compound metronidazole suppository, while the study group was treated with conjugated estrogen cream. Read More

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September 2018
3 Reads

[Interaction between vaginal micro-environment alterations and HPV16 infection in cervical intraepithelial neoplasia].

Zhonghua Liu Xing Bing Xue Za Zhi 2018 Nov;39(11):1486-1490

Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China.

To explore the effect of vaginal micro-environment alterations and HPV16 infection and their interaction in the progression of cervical intraepithelial neoplasia. The participants of this study came from the cervical lesions study cohort in Shanxi province, including 623 women with normal cervical (NC), 303 patients with pathogenically diagnosed low-grade cervical intraepithelial neoplasia (CINⅠ) and 93 patients with pathogenically diagnosed high-grade cervical intraepithelial neoplasia (CINⅡ/Ⅲ). The data of the demographic characteristics of the study subjects and factors related to cervical intraepithelial neoplasia were collected, and HPV16 infection were detected by using flow-through hybridization technology and H(2)O(2), β-glucuronidase, clotting enzyme, neuraminidase and leucocyte esterase in vaginal secretions were detected by using the combined detection kit of aerobic vaginitis and bacterial vaginosis. Read More

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November 2018
3 Reads

Localized Provoked Vulvodynia: Association With Nerve Growth Factor and Transient Receptor Potential Vanilloid Type 1 Genes Polymorphisms.

J Low Genit Tract Dis 2018 Nov 7. Epub 2018 Nov 7.

Department of Obstetrics & Gynecology, Galilee Medical Center, Nahariya, Israel.

Objective: The aim of the study was to study the associations between localized provoked vulvodynia (LPV) and several single-nucleotide polymorphisms (SNPs) in the transient receptor potential vanilloid type 1 (TRPV1), nerve growth factor (NGF), and the heparanase (HPSE) genes.

Materials And Methods: Prevalence of SNPs among 65 women with moderate or severe primary LPV (initial symptoms occur with first provoking physical contact) and 126 healthy, ethnically matched controls was analyzed in an observational case-control study. Each participant answered a questionnaire addressing familial LPV occurrence and comorbid pain conditions. Read More

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November 2018
4 Reads

Randomized, Double-Blind, Placebo-Controlled Study of Modified Erzhi Granules in the Treatment of Menopause-Related Vulvovaginal Atrophy.

Evid Based Complement Alternat Med 2018 14;2018:6452709. Epub 2018 Oct 14.

Tianjin University of Traditional Chinese Medicine, China.

Objective: To evaluate the clinical therapeutic efficacy and safety of modified Erzhi granules (MEG) in patients with menopause-related vulvovaginal atrophy (VVA).

Methods: This randomized, double-blind, placebo-controlled study comprised two groups, including the treatment and control groups. Patients receive MEG and placebo for 12 weeks, respectively. Read More

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October 2018
7 Reads
1.880 Impact Factor

Genitourinary Changes with Aging.

Obstet Gynecol Clin North Am 2018 Dec 25;45(4):737-750. Epub 2018 Oct 25.

Department of Obstetrics and Gynecology, University of California, Davis, 4860 Y Street, Suite 2500, Sacramento, CA 95817, USA. Electronic address:

Both chronologic aging and menopause affect the physical, physiologic, and microbiological characteristics of the genitourinary tract. The genitourinary syndrome of menopause, characterized by vulvovaginal and lower urinary tract signs and symptoms, is prevalent and has a significant negative impact on women's lives. In this article, the authors detail the genitourinary tract changes associated with menopause and/or aging. Read More

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December 2018
9 Reads

Transvaginal natural orifice transluminal endoscopic surgery in the diagnosis of ascites of unknown origin.

Gastrointest Endosc 2018 Oct 31. Epub 2018 Oct 31.

Department of Gastroenterology and Hepatology, the General Hospital of the Chinese People's Liberation Army, Beijing, China. Electronic address:

Background And Aims: Natural orifice transluminal endoscopic surgery (NOTES) has been established in animal models and human studies, but few clinical studies have investigated transvaginal NOTES in the diagnosis of unexplained refractory ascites. We aimed to assess the feasibility, efficacy, and safety of transvaginal NOTES for the diagnosis of unexplained ascites in female patients.

Methods: A prospective study was done involving 3 female patients with unexplained ascites. Read More

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October 2018
9 Reads

An Update on the Roles of Non- Species in Vulvovaginitis.

J Fungi (Basel) 2018 Oct 31;4(4). Epub 2018 Oct 31.

Department of Medical Microbiology and Parasitology, University of Ibadan, Ibadan 200284, Nigeria.

species are one of the commonest causes of vaginitis in healthy women of reproductive age. Vulvovaginal candidiasis (VVC) is characterized by vulvovaginal itching, redness and discharge. , which is a common genito-urinary tract commensal, has been the prominent species and remains the most common fungal agent isolated from clinical samples of patients diagnosed with VVC. Read More

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October 2018
1 Read

The human microbiome: implications for health and disease, including HIV infection.

Top Antivir Med 2018 Sep;26(3):75-78

University of California San Diego, La Jolla, CA, USA.

Our increased understanding of the human microbiome has brought insight into the role it plays in health and disease, including HIV infection. Studies have shown that the gut microbiome is less diverse in individuals with HIV infection than in noninfected control subjects. Efforts to modify the microbiome to bolster immune reconstitution in people with HIV infection have so far been unsuccessful. Read More

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September 2018
1 Read

Association between the vaginal microbiota, menopause status, and signs of vulvovaginal atrophy.

Menopause 2018 Nov;25(11):1321-1330

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.

Objective: The vaginal microbiota helps protect the female genital tract from disease. We sought to describe the composition of the vaginal microbiota in premenopausal, perimenopausal, and postmenopausal women and to explore the association between the microbiota and vulvovaginal atrophy (VVA).

Methods: Eighty-seven women (aged 35-60 y) were classified as premenopausal (n = 30), perimenopausal (n = 29), or postmenopausal (n = 28) according to Stages of Reproductive Aging Workshop guidelines. Read More

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November 2018
5 Reads

17β-estradiol vaginal tablet versus conjugated equine estrogen vaginal cream to relieve menopausal atrophic vaginitis.

Menopause 2018 Nov;25(11):1208-1213

Oshawa Clinic, Oshawa, Ontario, Canada.

Objectives: The efficacy and safety of 25-μg 17β-estradiol vaginal tablets (Vagifem) were assessed and compared with 1.25-mg conjugated equine estrogen vaginal cream (Premarin Vaginal Cream) for the relief of menopausal-derived atrophic vaginitis, resulting from estrogen deficiency.

Design: In a multicenter, open-label, randomized, parallel-group study, 159 menopausal women were treated for 24 weeks with either vaginal tablets or vaginal cream. Read More

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November 2018
6 Reads

Inhibition of CXCR4 by MicroRNA-1192 Reduces the Activation of Th17 Cells and Expression of Inflammation Factors in a Mouse Model of Vulvovaginal Candidiasis.

Cell Physiol Biochem 2018 24;50(3):893-910. Epub 2018 Oct 24.

Department of Obstetrics and Gynecology, Linyi People's Hospital, Linyi, China.

Background/aims: Vulvovaginal candidiasis (VVC) is a disease commonly occurring in sexually active women. The involvement of microRNAs in several kinds of infectious diseases has been highlighted in a number of researches. Therefore, we conducted the present study in order to investigate whether microRNA-1192 (miR-1192) would significantly target CXCR4 in Th17 cells as well as inflammatory factors in mouse models suffering from VVC. Read More

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November 2018
4 Reads
2.880 Impact Factor

Prevalence of Ureaplasma spp. and Mycoplasma hominis in healthy women and patients with flora alterations.

Diagn Microbiol Infect Dis 2018 Oct 4. Epub 2018 Oct 4.

Femicare Clinical Research for Women, 3300, Gasthuismolenstraat 31, Tienen, Belgium; Department of Obstetrics and Gynecology, Antwerp University, 2000, Prinsstraat 13, Antwerp, Belgium.

The objective was to estimate the prevalence of Mycoplasma hominis, Ureaplasma parvum, and Ureaplasma urealyticum in healthy women and patients with altered vaginal microflora. Vaginal samples from 2594 unselected female patients were divided into normal, bacterial vaginosis (BV), and aerobic vaginitis (AV) groups and tested for U. parvum, U. Read More

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October 2018
1 Read

[La ménopause et le traitement hormonal de la ménopause : une actualisation].

Rev Med Brux 2018;39(4):259-263

Service de Gynécologie-Obstétrique, CHU Saint-Pierre, ULB.

Postmenopausal hormone therapy (MHT) is mainly used for the relief of menopausal symptoms. It can also be prescribed for the treatment of postmenopausal osteoporosis, but nowadays, other medications are given to older patients for this indication. Current, available data, demonstrates that MHT is beneficial as well as safe for postmenopausal, symptomatic women. Read More

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December 2018
1 Read

Chemical Components and Biological Activities of the Genus : A Review of the Recent Literature.

Molecules 2018 Oct 8;23(10). Epub 2018 Oct 8.

Jiangxi Key Laboratory for Postharvest Technology and Nondestructive Testing of Fruits & Vegetables, Collaborative Innovation Center of Post-Harvest Key Technology and Quality Safety of Fruits and Vegetables, College of Agronomy, Jiangxi Agricultural University, Nanchang 330045, China.

Medicinal plants have served humans since prehistoric times to treat various ailments. Both developed and underdeveloped countries rely on traditional systems of medication using natural sources from plants. is one of the largest genus in the family Phyllanthaceae, comprising over 700 well known species cosmopolitan in distribution mainly in the tropics and subtropics. Read More

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October 2018
3 Reads

Associations of birth characteristics with perimenopausal disorders: a prospective cohort study.

J Dev Orig Health Dis 2018 Oct 9:1-7. Epub 2018 Oct 9.

1Department of Public Health Sciences,Karolinska Institutet,Stockholm,Sweden.

Perimenopausal disorders (PDs) are prevalent and importantly affect quality of life among middle-aged women. Yet, very little is known about the developmental origins of these disorders. The objective of this study was to investigate the associations of birth characteristics with PDs. Read More

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October 2018
1 Read

A high burden of asymptomatic genital tract infections undermines the syndromic management approach among adolescents and young adults in South Africa: implications for HIV prevention efforts.

BMC Infect Dis 2018 Oct 3;18(1):499. Epub 2018 Oct 3.

Perinatal HIV Research Unit (PHRU), Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Background: Youth in southern Africa, particularly adolescent girls and young women, are a key population for HIV prevention interventions. Untreated genital tract infections (GTIs) increase both HIV transmission and acquisition risks. South African GTI treatment guidelines employ syndromic management, which relies on individuals to report GTI signs and symptoms. Read More

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October 2018
1 Read

Alternative and complementary therapies for vulvovaginal candidiasis.

Folia Microbiol (Praha) 2018 Sep 30. Epub 2018 Sep 30.

Postgraduate Program in Health Sciences, Faculty of Medicine and Clinical Analysis Technical Course, Health Technical School, Federal University of Uberlandia, Uberlandia, Minas Gerais, Brazil.

When it comes to women's health, treating vaginal infections makes up a high proportion of the gynecological services. Among the forms of vaginitis, vulvovaginal candidiasis (VVC) is considered the second most common. Demand for new treatment alternatives is increasingly relevant, especially for therapies with fewer side effects, better tolerability, and lower cost, while still offering improved quality of life in terms of disease prevention. Read More

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September 2018
2 Reads

A mobile video intervention for women's health of North Korean defectors.

Public Health Nurs 2018 Nov 27;35(6):558-562. Epub 2018 Sep 27.

Chung-Ang University, Seoul, South Korea.

Background: The prevalence of North Korean female defectors is increasing in South Korea. Women who leave North Korea are exposed to sexual harassments, abuse, and other threats to their survival, which can have a devastating effect on their health.

Aims: In this study, a mobile video intervention program about selected aspects of women`s health was developed specifically for North Korean female defectors; its impact on behavioral change was evaluated. Read More

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November 2018
1 Read

Effect of pea protein plus grape seed dry extract on a murine model of Candida albicans induced vaginitis.

Future Microbiol 2018 09 26;13:1375-1382. Epub 2018 Sep 26.

Department of Chemical, Biological, Pharmacological & Environmental Sciences, University of Messina, Italy.

Aim: The objective of this research was to evaluate the antifungal properties of the association between grape seed and pea by using a nonpharmacological medical device that contains them.

Materials & Methods: A murine model of vulvovaginal candidiasis, induced by Candida albicans infection, was used.

Results: We showed that topical treatment with the device significantly reduced the fungal burden in vagina and preserved vagina tissue architecture from C. Read More

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September 2018
3 Reads

Candida africana in recurrent vulvovaginal candidiasis (RVVC) patients: frequency and phenotypic and genotypic characteristics.

J Med Microbiol 2018 Nov 4;67(11):1601-1607. Epub 2018 Oct 4.

4​Department of Medical Laboratory Sciences, Faculty of Paramedical, Bushehr University of Medical Sciences, Bushehr, Iran.

Purpose: Up to 75 % of all women develop vulvovaginal candidiasis (VVC), with symptoms such as vulvar erythema, pruritus and abnormal vaginal discharge. Despite the global distribution of Candida africana, its role in recurrent vulvovaginal candidiasis (RVVC) is still unclear and requires further investigation. Here, we report on the frequency of C. Read More

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November 2018
2 Reads

Association between unhygienic menstrual management practices and prevalence of lower reproductive tract infections: a hospital-based cross-sectional study in Odisha, India.

BMC Infect Dis 2018 Sep 21;18(1):473. Epub 2018 Sep 21.

School of Life Sciences, AIPH University, Bhubaneswar, Odisha, India.

Background: The extent to which reproductive tract infections (RTIs) are associated with poor menstrual hygiene management (MHM) practices has not been extensively studied. We aimed to determine whether poor menstrual hygiene practices were associated with three common infections of the lower reproductive tract; Bacterial vaginosis (BV), Candida, and Trichomonas vaginalis (TV).

Methods: Non-pregnant women of reproductive age (18-45 years) and attending one of two hospitals in Odisha, India, between April 2015 and February 2016 were recruited for the study. Read More

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September 2018
3 Reads

Efficacy and safety of combined high-dose interferon and red light therapy for the treatment of human papillomavirus and associated vaginitis and cervicitis: A prospective and randomized clinical study.

Medicine (Baltimore) 2018 Sep;97(37):e12398

Department of Dermatovenereology, Ningxia Yangguang Hospital, Yinchuan, China.

Background: We evaluated the efficacy and safety of combined high-dose interferon (IFN) and red light therapy for the treatment of subclinical and latent human papillomavirus (HPV) infections.

Methods: Ninety women diagnosed with subclinical or latent HPV infection were randomized to receive topical application of low-dose recombinant IFNα-2b (1 million IU), high-dose IFNα-2b (9 million IU), or a combination of high-dose IFNα-2b and red light therapy on the cervix and vagina. All patients received treatment once daily for 4 weeks. Read More

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September 2018
1 Read

Comparative risk of genital infections associated with sodium-glucose co-transporter-2 inhibitors.

Diabetes Obes Metab 2018 Sep 12. Epub 2018 Sep 12.

Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

The extent to which sodium-glucose co-transporter-2 (SGLT2) inhibitors increase the risk of genital infections in routine clinical care, compared with other antidiabetic medications, is not clear, or whether the increased risk is consistent across gender or age subgroups, within individual SGLT2 agents, or if it is more pronounced at a particular time after treatment initiation. We conducted a retrospective cohort study using two US commercial claims databases (2013-2017). In the primary analysis, 1:1 propensity score-matched cohorts of female and male subjects with type 2 diabetes mellitus initiating SGLT2 versus dipeptidyl peptidase-4 inhibitors were created. Read More

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September 2018
16 Reads

A tetravalent sialic acid-coated tetraphenylethene luminogen with aggregation-induced emission characteristics: design, synthesis and application for sialidase activity assay, high-throughput screening of sialidase inhibitors and diagnosis of bacterial vaginosis.

Chem Commun (Camb) 2018 Sep;54(76):10691-10694

College of Chemistry, Beijing Normal University, Beijing, 100875, China.

We report a turn-on tetravalent sialic acid-coated tetraphenylethene luminogen (TPE4S) with excellent hydrophilicity, good stability, high sensitivity and unique selectivity towards sialidases, and the maximum fluorescence enhancement was ∼40 fold. More importantly, TPE4S was successfully utilized for the screening of sialidase inhibitors and diagnosis of bacterial vaginosis. Read More

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September 2018
4 Reads
6.834 Impact Factor

Characterization of beta-tubulin DNA sequences within complex.

Curr Med Mycol 2018 Mar;4(1):24-29

Department of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background And Purpose: is a common cause of candidemia in children and patients with onco-hematological diseases, septic arthritis, peritonitis, vaginitis, and nail and skin infections. Regarding this, the present study was condcuted to evaluate intra- and inter-species variation within beta-tubulin DNA sequence of complex in order to establish the utilization of this gene in the identification and phylogenetic analysis of the species.

Materials And Methods: A total of 23 isolates representing three different species of complex were used in this study, all of which were identifed by ITS-sequencing. Read More

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March 2018
10 Reads

Chronic vulvovaginitis caused by Candida dubliniensis in an immunologically competent adult female.

Int J STD AIDS 2018 Aug 31:956462418792113. Epub 2018 Aug 31.

Department of Dermatology, Topiwala National Medical College & B.Y.L. Nair Hospital, Mumbai, India.

Candida, a commensal dimorphic fungus, is the most common microorganism that causes opportunistic fungal infections worldwide. It can cause diseases ranging from superficial mucosal infections to disseminated, systemic life-threatening infections. Among Candida species, Candida albicans is the most common infectious agent. Read More

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August 2018
2 Reads

Diagnosis and Treatment of Genitourinary Syndrome of Menopause.

Nurs Womens Health 2018 Oct 29;22(5):423-430. Epub 2018 Aug 29.

Genitourinary syndrome of menopause (GSM), formerly referred to as vulvovaginal atrophy or atrophic vaginitis, is a common chronic condition that requires a collaborative treatment plan between a health care provider and a woman to relieve symptoms and improve quality of life. Many women are not aware that symptoms can be controlled with treatment. Current treatment options approved for GSM include vaginal moisturizers, lubricants, and hormones. Read More

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October 2018
3 Reads

BIOMEDICAL PREVENTION OF HIV IN WOMEN: CHALLENGES AND APPROACHES, WITH PARTICULAR REFERENCE TO THE VAGINAL MICROBIOME.

Trans Am Clin Climatol Assoc 2018 ;129:63-73

BIRMINGHAM, ALABAMA.

Although great progress has been made in treating HIV-1 infection globally, incidence remains high in many locales, especially sub-Saharan Africa. Two-thirds of the burden of disease is there, and among those infected, 60% are women. Pre-exposure prophylaxis, the administration of a drug to prevent acquisition of infection, has proven to be a promising prevention modality for HIV-1 when administered as a daily oral regimen of tenofovir disoproxil fumarate/emtricitabine. Read More

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December 2018
1 Read

Candida parapsilosis Vaginal Infection-a New Site of Azole Drug Resistance.

Curr Infect Dis Rep 2018 Aug 27;20(11):43. Epub 2018 Aug 27.

Division of Infectious Diseases, Wayne State University School of Medicine, 540 E. Canfield St., 1241 Scott Hall, Detroit, MI, 48201, USA.

Purpose Of Review: Evaluation of pathogenicity of an uncommon vaginal Candida species, Candida parapsilosis with particular references to susceptibility to conventional antifungal agents.

Recent Findings: C. parapsilosis vaginal isolates usually present in asymptomatic women as commensals but may induce vulvovaginal symptoms indistinguishable from C. Read More

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August 2018
6 Reads

Association of gestational diabetes mellitus and abnormal vaginal flora with adverse pregnancy outcomes.

Medicine (Baltimore) 2018 Aug;97(34):e11891

Department of Obstetrics and Gynecology, Xuanwu Hospital, Capital Medical University.

Gestational diabetes mellitus (GDM) is associated with adverse perinatal outcomes. This study aimed to examine the association between GDM and abnormal vaginal flora, and the association between abnormal vaginal flora and adverse pregnancy outcomes.This was a prospective study of pregnant women who visited Xuanwu Hospital of the Capital Medical University (Beijing, China) between February and October 2015. Read More

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August 2018
2 Reads

Incidence and risk of vaginal candidiasis associated with sodium-glucose cotransporter 2 inhibitors in real-world practice for women with type 2 diabetes.

J Diabetes Investig 2018 Aug 23. Epub 2018 Aug 23.

Internal Medicine, Jiyugaoka Medical Clinic, Obihiro, Japan.

Aims/introduction: The prevalence and risk of vaginal candidiasis before and after initiating sodium-glucose cotransporter 2 (SGLT2) inhibitors, although some clinical trials have been carried out, have not been adequately shown in real-world practice. We investigated the incidence of vaginal Candida colonization and symptomatic vaginitis, and the clinical risk factors including diabetic microvascular complications.

Materials And Methods: The participants were 114 women with type 2 diabetes who were free of vaginitis symptoms and started SGLT2 inhibitors. Read More

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August 2018
7 Reads

Factors in the HIV risk environment associated with bacterial vaginosis among HIV-negative female sex workers who inject drugs in the Mexico-United States border region.

BMC Public Health 2018 Aug 20;18(1):1032. Epub 2018 Aug 20.

Department of Medicine, University of California, San Diego, USA.

Background: Bacterial vaginosis (BV) is the most common cause of vaginitis among women worldwide and is associated with increased susceptibility to sexually transmitted infections (STIs), including HIV. We aimed to determine the impact of the HIV risk environment on BV among female sex workers who inject drugs (FSW-PWIDs) in Tijuana and Ciudad Juarez, Mexico.

Methods: We performed a cross-sectional analysis utilizing baseline data from a randomized controlled trial evaluating a behavioral HIV prevention intervention. Read More

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August 2018
2 Reads

Infections During Pregnancy.

Prim Care 2018 Sep 9;45(3):567-586. Epub 2018 Jul 9.

Department of Family and Community Medicine, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA.

Several infections have unique consequences or considerations in pregnancy. Some common infections such as urinary tract infections, influenza, sexually transmitted diseases, and vaginitis affect pregnant women differently than the general population, can cause pregnancy complications, and require treatments that are safe in pregnancy. Infections such as hepatitis B and C and human immunodeficiency virus can be transmitted vertically and therefore management focuses on decreasing perinatal transmission. Read More

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September 2018
3 Reads

Tracking leading anti- compounds in plant samples; .

Iran J Microbiol 2018 Jun;10(3):187-193

Department of Biology, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Evin, Tehran, Iran.

Background And Objectives: Due to the importance of finding new and more effective antifungal and antibacterial compounds against invasive vaginitis strains, this study was conducted for fast screening of plant samples.

Materials And Methods: Thirty Iranian plant samples were successively extracted by -hexane, ethyl acetate and methanol to obtain a total of 90 extracts. Each extract was prepared in six concentrations and evaluated for antifungal activity via a micro-broth dilution method. Read More

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June 2018
2 Reads

Estimated burden of serious human fungal diseases in Turkey.

Mycoses 2018 Aug 14. Epub 2018 Aug 14.

The National Aspergillosis Centre, Wythenshawe Hospital, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

The current number of fungal infections occurring each year in Turkey is unknown. We estimated the burden of serious human fungal diseases based on the population at risk, existing epidemiological data from 1920 to 2017 and modelling previously described by the LIFE program (http://www.LIFE-worldwide. Read More

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August 2018
11 Reads

Metronidazole-Resistant Trichomoniasis: Beneficial Pharmacodynamic Relationship With High-Dose Oral Tinidazole and Vaginal Paromomycin Combination Therapy.

Sex Transm Dis 2019 Jan;46(1):e1-e2

From the Department of Obstetrics and Gynecology, Drexel Vaginitis Center, Philadelphia, PA.

Metronidazole-resistant trichomoniasis is an uncommon condition that presents significant therapeutic challenges. Combination therapy with high-dose oral tinidazole and vaginal paromomycin cream has been uniformly successful. We present a case report of a patient who responded to combination therapy with high-dose oral tinidazole and intravaginal paromomycin. Read More

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January 2019

Loop-mediated isothermal amplification for the rapid detection of Gardnerella vaginalis.

Microbiol Immunol 2018 Sep;62(9):607-611

Department of Microbiology, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.

The aim of this study was to develop a method for the rapid detection of Gardnerella vaginalis, which is proposed to play a key role in the pathogenesis of bacterial vaginosis. Specific loop-mediated isothermal amplification (LAMP) primers were designed and used to detect target DNA within 45 min under isothermal conditions. Comparative screening indicated that the LAMP assay is superior to PCR in terms of rapidity, and is equivalent in sensitivity and specificity. Read More

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September 2018
5 Reads

Treatment-refractory vulvodynia from nutcracker syndrome: A case report.

Case Rep Womens Health 2018 Jul 30;19:e00071. Epub 2018 Jun 30.

The Pelvic Solutions Center, Denver, CO, United States.

Background: Pelvic venous disorders are often undiagnosed due to the symptom variability and similarity to other disease presentations. 'Pelvic congestion syndrome' is a term often used as a diagnosis of exclusion, since there is currently no standardized diagnostic approach for pelvic venous disorders, which further delays treatment.

Case: A 25-year-old woman with treatment-refractory vulvodynia presented with symptoms that included left-sided vaginal wall pain, pruritis, dysmenorrhea, dyspareunia, muscle tension, and a chronic vaginal ulceration. Read More

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July 2018
14 Reads

Common Illnesses in Tropical Asia and Significance of Medical Volunteering.

Open Med (Wars) 2018 30;13:285-293. Epub 2018 Jul 30.

Department of Oral & Maxillofacial Surgery, Guro Hospital, 148 Gurodong-ro, Guro 2-dong, Guro-gu, Seoul, 08308, Republic of Korea.

This study was conducted to provide practical information for actual preparation of medical volunteering in tropical Asia, mainly the distribution of common illnesses encountered during mission. From 2012 to 2017, we visited two rural areas of Eastern Cambodia for medical volunteering missions, Cham Lak and Khsoem. Neither area has electricity or public water. Read More

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July 2018
1 Read