13,879 results match your criteria Vaginitis

Real-world effectiveness and tolerability of Zelesse cream® for treating vulvovaginitis in adult women: an observational, prospective study.

J Int Med Res 2021 May;49(5):3000605211013226

Medical Department, ITF Research Pharma S.L.U., Madrid, Spain.

Objective: To assess the efficacy, acceptability, and tolerability of a vaginal cream based on plant extracts for treating signs and symptoms of vulvovaginitis (VV) (Zelesse cream®), either as monotherapy (non-infectious VV) or adjuvant to antimicrobial therapy (infectious VV).

Methods: This prospective, observational, multicenter study included women who attended outpatient offices for VV. The severity of signs (vaginal discharge, erythema, and edema) and symptoms (pruritus, burning, and dysuria) was assessed before and after 15±5 days of daily treatment with Zelesse cream on a 4-point scale (18-point global score). Read More

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Treatment methods for vulvovaginal candidiasis in pregnancy.

J Mycol Med 2021 May 7;31(3):101138. Epub 2021 May 7.

Department of Obstetrics and Gynecology, Okan University School of Medicine, Istanbul, Turkey.

Introduction: Vulvovaginal candidiasis (VVC) is one of the three most common vaginal infections of women. Our goal is to check which treatment method (vaginal or vaginal combined with oral) is more effective for each trimester to treat VVC.

Materials And Method: A retrospective analysis was performed and vaginal culture results after treatment of 61 pregnant women who were treated with vaginal or vaginal plus oral antifungals, were collected. Read More

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What Is Genitourinary Syndrome of Menopause and Why Should We Care?

Kelly Jo Peters

Perm J 2021 May;25

Colorado Permanente Medical Group, Denver, CO.

None: Genitourinary syndrome of menopause (GSM; previously known as vulvovaginal atrophy or atrophic vaginitis) involves symptoms of vaginal dryness, burning, and itching as well as dyspareunia, dysuria, urinary urgency, and recurrent urinary tract infections. It is estimated that nearly 60% of women in menopause experience GSM but the majority of these women do not bring up this concern with their health care provider. Studies also show that only 7% of health care providers ask women about this condition. Read More

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Clinical Manifestations of Polycystic Ovary Syndrome and Associations With the Vaginal Microbiome: A Cross-Sectional Based Exploratory Study.

Front Endocrinol (Lausanne) 2021 23;12:662725. Epub 2021 Apr 23.

Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.

Background: Previous studies suggest that the vaginal microbiome is associated with polycystic ovary syndrome (PCOS). However, the clinical manifestations of PCOS are heterogeneous. Whether the vaginal microbiome is related with different clinical symptoms was unknown. Read More

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Updates on Therapeutic Alternatives for Genitourinary Syndrome of Menopause: Hormonal and Non-Hormonal Managements.

J Menopausal Med 2021 Apr;27(1):1-7

Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Postmenopausal atrophic vaginitis, along with vasomotor symptoms and sleep disorders, is one of the most troublesome symptoms of menopause. However, many women do not manage this symptom properly due to insufficient knowledge of the symptoms or sexual embarrassment. With appropriate treatment, many postmenopausal women can experience relief from discomforts, including burning sensation or dryness of the vagina and dyspareunia. Read More

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Bacterial agents in vulvovaginitis and vaginal discharge: a 10-year retrospective study in the Netherlands.

Eur J Clin Microbiol Infect Dis 2021 May 3. Epub 2021 May 3.

Laboratory of Clinical Microbiology and Infectious Diseases, Isala Hospital, Dr. van Heesweg 2, 8025 AB, Zwolle, The Netherlands.

Vulvovaginitis is a common problem in the GP's practice. Causes are bacterial vaginosis (BV), Candida infection and sexually transmitted infections (STIs). Only if empirical treatment fails, a vaginal swab is sent in for culture and BV detection. Read More

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Interventions Preventing Vaginitis, Vaginal Atrophy after Brachytherapy or Radiotherapy Due to Malignant Tumors of the Female Reproductive Organs-A Systematic Review.

Int J Environ Res Public Health 2021 Apr 8;18(8). Epub 2021 Apr 8.

Department of Oncology, Poznan University of Medical Science, Szamarzewskiego 82/84 St, 60-569 Poznan, Poland.

Background: Radiotherapy, as a method of treatment of cervical and uterine cancers, may induce severe late-onset vaginal side effects. Unfortunately, little evidence on the management of adverse effects has been presented. This study aimed to evaluate the available interventions which reduce symptoms of vaginitis and vaginal atrophy by improving dyspareunia, mucosal inflammation, vaginal pH and vaginal dryness in women who have undergone brachytherapy or radiotherapy due to uterine or cervical malignancies. Read More

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Aerobic Vaginitis Induced by Infection During Pregnancy Can Result in Adverse Pregnancy Outcomes Through the IL-4/JAK-1/STAT-6 Pathway.

Front Microbiol 2021 7;12:651426. Epub 2021 Apr 7.

Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China.

Aerobic vaginitis (AV) can occur if normal vaginal microflora are dominated by aerobic bacteria, seriously affects not only female health, but also fetal health while they are pregnant. Besides, pregnant status also aggravates the symptoms and consequences of the infection. Here, we infected pregnant BALB/c mice with on embryonic day 4. Read More

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The association between imbalances in vaginal microflora and duration of pregnancy as well as selected maternal and neonatal parameters.

Ginekol Pol 2021 Apr 12. Epub 2021 Apr 12.

Department of Surgical and Oncologic Gynecology, 1st Department of Gynecology and Obstetrics, Medical University of Lodz, Poland.

Objectives: Abnormal vaginal flora (AVF) is a result of excessive growth of some aerobic bacteria and fungi in relation to the scarce presence of Lactobacillus spp. It has been suggested that AVF is responsible for preterm birth and such neonatal conditions as infections or sepsis. The aim of the study was to assess the influence of excessive vaginal colonization with aerobic bacteria and fungi on the selected postnatal parameters of newborns, duration of pregnancy and length of hospitalisation of neonates. Read More

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Georgian Med News 2021 Feb(311):46-50

2Microbiology and Immunology Institute of National Academy of Medical Sciences, Kharkiv, Ukraine.

Along with sexually transmitted infections opportunistic pathogens and normal microbiota are becoming increasingly clinically important. Opportunistic pathogens can lead to purulent-inflammatory process of the genitals The aim of the current work was to detect qualitative and quantitative composition of vagina contents in non-specific bacterial vaginosis. Vaginal microbiota of 298 women aged from 16 to 64 years old was analyzed. Read More

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February 2021


Wiad Lek 2021 ;74(3 cz 1):460-464


Objective: The aim: To assess the condition of the vaginal ecosystem in pregnant women with BV.

Patients And Methods: Materials and methods: The main group consisted of 60 pregnant women with BV in the II trimester. The bacterioscopic examination, of vaginal smears was carried out. Read More

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Wiad Lek 2021 ;74(3 cz 1):406-412


Objective: The aim: To obtain the first estimates of the current prevalence of healthcare-associated deep pelvic tissue infection and other infections of the female reproductive tract (vagina, ovaries, uterus) including chorioamnionitis, and antimicrobial resistance of causing pathogens in Ukraine.

Patients And Methods: Materials and methods: We performed a retrospective multicenter cohort study was based on surveillance data. The study population included 3,053 women's who underwent gynecological surgery or other procedures from 2017 to 2019 in 7 women hospitals in Ukraine. Read More

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STROBE-sequencing analysis of the vaginal microecology of 4- to 6-year-old girls in Southwest China.

Medicine (Baltimore) 2021 Apr;100(13):e25362

Department of Laboratory Medicine, West China Second University Hospital, Sichuan University.

Abstract: We investigated the vaginal flora diversity of preschool-aged (ie, 4-6-year-old) girls in southwest China.Fourteen preschool-aged girls were enrolled in this study. The statuses and differences in their vaginal flora were evaluated by Gram staining, bacterial culturing, and sequencing analysis. Read More

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A case report of septic gardnerellosis.

IDCases 2021 10;24:e01069. Epub 2021 Mar 10.

Department of Infectious Diseases, Danylo Halytsky Lviv National Medical University, 69 Pekarska Str., Lviv, Ukraine.

is a bacterium that is found as the most common cause of bacterial vaginitis in women. In this paper, we describe a case report of a 22-years old woman infected with , who was initially suspected to have Dengue fever. The similarity of clinical symptoms developed by this disease with the symptoms of some other tropical infectious diseases, as well as a travel history, complicated identification of the disease cause for this particular patient. Read More

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Comparison of the effectiveness of and clotrimazole vaginal creams for the treatment of vulvovaginal candidiasis.

J Med Life 2021 Jan-Mar;14(1):111-117

Department of Biostatistics and Epidemiology, Faculty of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Candidal vaginitis has a relatively high prevalence, and its resistance to treatment is on the rise. Considering the complications of chemical drugs, the use of herbal medicines has now been favored due to the lack of changes in the normal vaginal flora. The aim of this study was to compare the effectiveness of and clotrimazole vaginal creams for the treatment of candidal vulvovaginitis. Read More

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Chitosan-based systems aimed at local application for vaginal infections.

Carbohydr Polym 2021 Jun 6;261:117919. Epub 2021 Mar 6.

School of Pharmaceutical Sciences, São Paulo State University, Araraquara, SP, Brazil. Electronic address:

Vaginal administration is a promising route for the local treatment of infectious vaginal diseases since it can bypass the first-pass metabolism, drug interactions, and adverse effects. However, the commercial products currently available for topical vulvovaginal treatment have low acceptability and do not adequately explore this route. Mucoadhesive systems can optimize the efficacy of drugs administered by this route to increase the retention time of the drug in the vaginal environment. Read More

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Evaluation of the presence of SARS-COV-2 in the vaginal fluid of reproductive-aged women.

Ginekol Pol 2021 Mar 10. Epub 2021 Mar 10.

Department of Microbiology, Sakarya Training and Research Hospital, Sakarya, Turkey.

Objectives: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is mainly transmitted through respiration and direct contact. The status of the infection in the female genital system is still unknown. The study aimed to evaluate whether SARS-CoV-2 is present in the vaginal fluid of women with COVID-19 infection in reproductive period. Read More

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Response to "caution regarding interpretations of intrauterine γδ T cells in protection against experimental vaginal candidiasis".

L Monin A Hayday

Mucosal Immunol 2021 05 17;14(3):776-777. Epub 2021 Mar 17.

ImmunoSurveillance Lab, The Francis Crick Institute, London, UK.

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Caution regarding interpretations of intrauterine γ/δ T cells in protection against experimental vaginal candidiasis.

Paul L Fidel

Mucosal Immunol 2021 05 17;14(3):774-775. Epub 2021 Mar 17.

Department of Oral and Craniofacial Biology, Louisiana State University Health School of Dentistry, New Orleans, Louisiana, USA.

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The Effect of Panax ginseng on Genitourinary Syndrome in Postmenopausal Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Complement Med Res 2021 Mar 17:1-8. Epub 2021 Mar 17.

Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Menopause and estrogen deprivation cause a rise in the number of urogenital tract complaints.

Objective: This study was conducted to assess the effectiveness of ginseng on genitourinary syndrome.

Methods: This randomized trial was conducted on 60 postmenopausal women with genitourinary syndrome. Read More

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Synthesis, characterization, and evaluation of BDDE crosslinked chitosan-TGA hydrogel encapsulated with genistein for vaginal atrophy.

Carbohydr Polym 2021 May 20;260:117832. Epub 2021 Feb 20.

Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, No. 49, Fanglan Rd, Taipei, 10672, Taiwan; Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, No. 35, Keyan Road, Zhunan, Miaoli County, 35053, Taiwan. Electronic address:

Vagina atrophy is a common symptom in women after menopause owing to decreasing estrogen levels. The most conventional treatment for this condition is estrogen cream. The shortcoming is its weak adhesion to the vagina mucus, thus requiring frequent daily application. Read More

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Novel insights in bacterial vaginosis etiology through genomic approaches.

An Acad Bras Cienc 2021 8;93(2):e20200945. Epub 2021 Mar 8.

Universidade Federal de Minas Gerais, Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Av. Presidente Antônio Carlos, 6627, Pampulha, 31270-901 Belo Horizonte, MG, Brazil.

Bacterial vaginosis (BV) has been considered as dysbiosis state whose etiology is not fully understood. This condition affects a large number of women of reproductive age and its study has been highly relevant due to the growing association of BV with and gynecological and obstetric complications and diseases, in addition to a greater susceptibility to sexually transmitted diseases, including HIV. The vaginal microbiota composition presents high variability among different ethnic groups of women, although, generally, the prevalence of lactobacilli species has been reported. Read More

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Recurrent bacterial vaginosis.

Nursing 2021 Mar;51(3):48-52

At the University of North Carolina in Wilmington, N.C., Kelly Ellington and Scott J. Saccomano are assistant professors.

Abstract: Bacterial vaginosis increases the risk of sexually transmitted infections, including HIV, and treatment is crucial to avoid complications. This article reviews the evidence-based options for treating bacterial vaginosis to improve patient outcomes. Read More

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Metronidazole-Induced Recurrent Paresthesia: A Case Report.

Yunsoo Soh

Neurol India 2021 Jan-Feb;69(1):174-176

Department of Physical Medicine and Rehabilitation, Kyung-Hee Medical Center, 23, Kyungheedae-ro, Dongdaemun-gu, Seoul, Korea.

A 54-year-old woman presented with a 1-month history of pain and numbness in both feet. She had taken metronidazole for over 4 years previously to treat vaginitis. On nerve conduction studies (NCS), neither the sural nor right superficial peroneal nerve (SPN) was evoked, nor did the left SPN have small amplitude, suggesting axonal peripheral polyneuropathy with sensory fiber involvement. Read More

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The International Society for the Study of Vulvovaginal Disease Vaginal Wet Mount Microscopy Guidelines: How to Perform, Applications, and Interpretation.

J Low Genit Tract Dis 2021 Apr;25(2):172-180

Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, IA.

Objectives: The aims of the study were to assess the available literature concerning the indications, performance, technique, and classification of wet mount microscopy (WMM) and to establish evidence-based recommendations.

Methods: Literature review from the main scientific databases was performed by the ad hoc "Vaginitis and Microbiome Committee" of the International Society for the Study of Vulvovaginal Disease. The document was approved by the executive council and membership of the International Society for the Study of Vulvovaginal Disease. Read More

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Prevalence, Etiology, and Associated Symptoms of Vaginal Discharge During Pregnancy in Women Seen in a Tertiary Care Hospital in Bihar.

Cureus 2021 Jan 14;13(1):e12700. Epub 2021 Jan 14.

Microbiology Department, Indira Gandhi Institute of Medical Sciences, Patna, IND.

Introduction Vaginal discharge is the most frequent complaint during pregnancy, leading to numerous complications in both the mother and fetus. Aim The goal of this study was to determine the prevalence of vaginal discharge, investigate its common infectious causes and associated symptoms during pregnancy. Methods This hospital-based cross-sectional study performed over one year evaluated 200 expectant mothers with vaginal discharge at any trimester in the Department of Obstetrics and Gynecology, in cooperation with the Microbiology section, of Indira Gandhi Institute of Medical Science, Patna. Read More

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January 2021

Hand-Held Zoom Micro-Imaging System Based on Microfluidic Chip for Point-of-Care Testing (POCT) of Vaginal Inflammation.

IEEE J Transl Eng Health Med 2021;9:2800109. Epub 2021 Jan 26.

Department of Food and Biological EngineeringJiangsu UniversityZhenjiang212013China.

Background: Vaginitis is a common and very private disease, and the current diagnosis is a frequent go to the hospital for testing.

Objective: In order to improve the convenience and speed of detection, in this paper, we have developed a hand-held zoom micro-imaging system based on a microfluidic chip for point-of-care testing (POCT) of vaginal inflammation.

Methods: This system consists of a microfluidic chip, an optical system and a hand-held zoom system assembled with a mobile phone. Read More

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January 2021

Investigating natural antibiofilm components: a new therapeutic perspective against candidal vulvovaginitis.

Med Hypotheses 2021 Mar 26;148:110515. Epub 2021 Jan 26.

Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, Delhi 110062, India. Electronic address:

The rampant emergence of Candida albicans in the vagina and its ability to thrive as a biofilm has outstood the prevalence of candidal vulvovaginitis (CVV), a gender-based fungal infection approximately affecting 75% of the global female population. The biofilm represents a multidimensional microbial population, which often dictates prominent caveats of CVV such as increased fungal virulence, drug resistance and infection relapse/recurrence. Additionally, the conjugated issues of the ineffectiveness of conventional antifungals (azoles), prolonged treatment durations, compromised patient compliance, economic and social burden, exacerbates CVV complications as well. Read More

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Clinical validation of a new molecular test (Seegene Allplex™ Vaginitis) for the diagnosis of vaginitis: a cross-sectional study.

BJOG 2021 Feb 4. Epub 2021 Feb 4.

LAP, a Unilabs Company, Porto, Portugal.

Objective: To validate the use of Seegene Allplex™ Vaginitis assay in the diagnosis of candidiasis, bacterial vaginosis (BV) and trichomoniasis.

Design: Cross-sectional, prospective study conducted in a single centre.

Setting: Outpatient clinic of a gynaecology department. Read More

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February 2021