30,372 results match your criteria Vaginal Cancer


Primary Vaginal Carcinoma Arising on Cystocele Mimicking Vulvar Cancer.

J Obstet Gynaecol Can 2020 Apr 6. Epub 2020 Apr 6.

Department of Biomedical Sciences and Human Oncology, Unit of Obstetrics and Gynecology, University of Bari Aldo Moro, Bari, Italy.

Background: Primary vaginal carcinoma is a rare gynaecological tumour representing 1%-3% of all gynaecologic cancers. Several studies report increased vaginal cancer risk associated with genital prolapse following the occurrence of inflammatory lesions or decubitus ulcers.

Case: We report the rare case of an 82-year-old woman with primary squamous cell carcinoma arising from vaginal wall prolapse. Read More

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http://dx.doi.org/10.1016/j.jogc.2020.03.007DOI Listing

Corrigendum to "Efficacy of strategies to increase participation in cervical cancer screening: GPs offering self-sampling kits for HPV testing versus recommendations to have a pap smear taken - A randomised controlled trial". Papillomavirus Research 9 (2020) 100194.

Papillomavirus Res 2020 May 8:100201. Epub 2020 May 8.

Unit of Cancer Epidemiology, Belgian Cancer Centre, Sciensano, Brussels, Belgium. Electronic address:

Background: Cervical cancer is preventable by early detection and treatment of pre-cancerous lesions. The current screening policy in Belgium (3-yearly cytology on Pap smears) covers 60% of the target population. Offering self-samples by GPs can overcome barriers for women who are currently not screened. Read More

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http://dx.doi.org/10.1016/j.pvr.2020.100201DOI Listing

Comparison of two self-sampling methods for Human Papillomavirus (HPV) DNA testing among women with high prevalence rates.

J Med Virol 2020 May 21. Epub 2020 May 21.

Department of Obstetrics and Gynecology, Government Medical College, Kozhikode, Kerala, India.

One major advantage of molecular assays for Human Papillomavirus (HPV) DNA detection is that these assays can be performed on self-collected samples unlike cytology or Visual Inspection with Acetic acid (VIA). This cross-sectional study was carried out between March 2017 and April 2019 to compare the diagnostic performance in self-collected urine and vaginal samples for HPV DNA detection. Viral DNA was extracted from processed samples using the Qiagen viral DNA extraction Kit (QIAamp DNA Mini Kit). Read More

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http://dx.doi.org/10.1002/jmv.26043DOI Listing

Clear cell carcinoma in a urethral diverticulum.

Urol Case Rep 2020 Sep 3;32:101164. Epub 2020 Apr 3.

Department of Urology, Guy's and St Thomas' NHS Foundation Trust, London, UK.

A 54-year-old female presented with a long history of multi-drug-resistant urinary tract infections, urinary urgency and frequency, haematuria, stress urinary incontinence and difficulty voiding. Examination revealed a large, hard anterior vaginal wall mass with purulent discharge. Investigation with MRI demonstrated a complex urethral diverticulum containing stones with fistulation into the vagina. Read More

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http://dx.doi.org/10.1016/j.eucr.2020.101164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229268PMC
September 2020

Vaginal Microbiota and HPV Infection: Novel Mechanistic Insights and Therapeutic Strategies.

Infect Drug Resist 2020 30;13:1213-1220. Epub 2020 Apr 30.

Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, People's Republic of China.

Cervical cancer is a global public health concern. The complex interaction of genetic and environmental factors is critical for the progress of cervical cancer. Growing evidence suggests that microbes, human papillomavirus (HPV), and the immune system interact closely with each other to govern homeostasis of the vaginal environment and the health of the lower genital tract of females. Read More

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http://dx.doi.org/10.2147/IDR.S210615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198448PMC

An Alternative Treatment for Vaginal Cuff Wart: a Case Report.

Acta Medica (Hradec Kralove) 2020 ;63(1):49-51

Department of Gynecologic Oncology, Metaxa Memorial Cancer Hospital, Piraeus, Greece.

Human papillomavirus (HPV) has been directly related to acuminate warts and cervical cancer, the second most common neoplasia among women. Given the lack of treatment against the virus itself, many medications have been utilised, mainly aiming in modifying the host's immunological response. We present the case of a 54 years old postmenopausal patient with a history of vaginal cuff wart and HPV persistence that we managed in our clinic for 6 months with a mix of curcumin, aloe vera, amla and other natural ingredients. Read More

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http://dx.doi.org/10.14712/18059694.2020.15DOI Listing
January 2020

Predictors of Women's Sexual Outcomes After Implant-Based Breast Reconstruction.

Psychooncology 2020 May 17. Epub 2020 May 17.

Department of Plastic, Reconstructive and Hand Surgery, Amsterdam University Medical Center (VUmc), Amsterdam, the Netherlands.

Objective: Although breast reconstruction has become an important treatment modality following mastectomy, few studies assessed predictors of postoperative sexual outcomes after breast reconstruction. Therefore, we aimed to study three sexual outcomes following implant-based breast reconstruction (IBBR), and associate multiple biopsychosocial factors with these outcomes.

Methods: Data collection was part of a multicenter prospective study on IBBR. Read More

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http://dx.doi.org/10.1002/pon.5415DOI Listing

DoE based optimization and development of spray-dried chitosan-coated alginate microparticles loaded with cisplatin for the treatment of cervical cancer.

Curr Mol Pharmacol 2020 May 17. Epub 2020 May 17.

Department of Pharmaceutics, ISF College of Pharmacy, Moga (Punjab). India.

Background: The existing parenteral treatment of cervical cancer has high toxicity and poor distribution of drugs at the targeted site.

Purpose: To formulate localized mucoadhesive cisplatin loaded microparticles based formulation to treat cervical cancer so that enhanced therapeutics benefits with low toxicity could be achieved.

Methods: Cisplatin loaded chitosan coated spray-dried microparticles were prepared by ionotropic gelation technique and optimized by Central Composite Design. Read More

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http://dx.doi.org/10.2174/1874467213666200517120337DOI Listing

Management of pregnancy after fertility-sparing surgery for cervical cancer.

Acta Obstet Gynecol Scand 2020 May 16. Epub 2020 May 16.

Department of Gynecology and Obstetrics, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.

Cervical cancer is increasingly diagnosed in women who have not yet completed their reproductive plans. For patients with early stages (FIGO stage IA2 and IB1), fertility-sparing procedures, such as conization, trachelectomy or radical trachelectomy, represent the treatment of choice. However, patients who undergo repeated conization or trachelectomy represent a challenge for obstetricians as they are at increased risk of infertility, mid-trimester abortion, preterm premature rupture of membranes and preterm delivery. Read More

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http://dx.doi.org/10.1111/aogs.13917DOI Listing

Management and long-term consequences of genital graft versus host disease following hematopoietic stem cell transplantation.

Bone Marrow Transplant 2020 May 15. Epub 2020 May 15.

Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Vulvovaginal Graft-versus-host disease (VV-GVHD) is an underdiagnosed complication of hematopoietic stem cell transplantation (HSCT). The severity of the disease varies greatly, ranging from minor discomfort to severe, irreversible anatomic changes. This study sought to assess the long-term course of VV-GVHD. Read More

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http://dx.doi.org/10.1038/s41409-020-0933-2DOI Listing

Assessment of Prediagnostic Experiences of Black Women With Endometrial Cancer in the United States.

JAMA Netw Open 2020 May 1;3(5):e204954. Epub 2020 May 1.

Department of Surgery, University of Washington School of Medicine, Seattle.

Importance: Black women with endometrial cancer have a 90% higher mortality rate than white women with endometrial cancer. The advanced disease stage at which black women receive a diagnosis of endometrial cancer is a major factor in this disparity and is not explained by differences in health care access.

Objective: To describe the prediagnostic experiences of symptoms and symptom disclosure among black women with endometrial cancer. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.4954DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229523PMC

Geographic and temporal variations in the incidence of vulvar and vaginal cancers.

Int J Cancer 2020 May 14. Epub 2020 May 14.

Unit of Cancer Epidemiology, Belgian Cancer Centre, Brussels, Belgium.

Vulvar and vaginal cancers are relatively rare cancers, together responsible for 1.5% of the global cancer incidence among women in 2018. The majority of vaginal cancers, and a lesser proportion of vulvar cancers are associated with HPV. Read More

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http://dx.doi.org/10.1002/ijc.33055DOI Listing

Feasibility of implementing a cervix cancer-specific patient-reported outcome measure in routine ambulatory clinics.

Support Care Cancer 2020 May 13. Epub 2020 May 13.

Department of Radiation Oncology, University of Toronto, 610 University Ave, Toronto, ON, M5G 2M9, Canada.

Objective: To evaluate the implementation of a cervix cancer-specific patient-reported outcome measure, the European Organization for Research and Treatment of Cancer Quality of Life Cervical Cancer module (EORTC QLQ-CX24), into gynecologic oncology clinics.

Methods: This was a prospective, multi-institutional, cross-sectional study involving cervix cancer patients previously treated with curative intent radiotherapy who were attending routine follow-up appointments. Between January 2017 and August 2018, eligible patients were approached to complete the EORTC QLQ-CX24 prior to their clinical encounter and then review it with their oncologist. Read More

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http://dx.doi.org/10.1007/s00520-020-05500-2DOI Listing
May 2020
2.364 Impact Factor

An application of ERBB2 receptor inhibitors in a rare case of S310F somatic ERBB2 mutation of primary signet-ring cell adenocarcinoma of vagina: A case report and review literature of S310F somatic ERBB2 mutation in breast and gynecologic cancers.

Gynecol Oncol Rep 2020 May 1;32:100577. Epub 2020 May 1.

Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand.

•The extremely uncommon subtype of epithelial vaginal cancer.•Comprehensive genomic sequencing of the rare subtype vaginal cancer.•Incorporated of the actionable targeted drugs in the treatment of uncommon cancer based on the comprehensive genomic profile. Read More

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http://dx.doi.org/10.1016/j.gore.2020.100577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212178PMC

Factors associated with counseling and postoperative hormone therapy use in surgically menopausal women.

Menopause 2020 May 11. Epub 2020 May 11.

Department of Obstetrics and Gynecology, School of Medicine and Public Health, University of Wisconsin, Madison WI.

Objective: To determine the rates of and factors associated with preoperative counseling about menopausal symptoms and use of hormone therapy postoperatively in surgically menopausal women.

Methods: This retrospective chart review included patients who underwent bilateral oophorectomies before age 52 at an academic institution during a 3-year period. We used descriptive analyses to characterize the sample and logistic regression to identify factors associated with preoperative counseling about and postoperative systemic hormone therapy for menopausal symptoms. Read More

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http://dx.doi.org/10.1097/GME.0000000000001560DOI Listing

Does the Interval Between Hysterectomy and Start of Adjuvant Radiation Treatment Influence Survival in Women With Endometrial Carcinoma?: A National Cancer Database analysis.

Am J Clin Oncol 2020 May 8. Epub 2020 May 8.

Departments of Radiation Oncology.

Objective: The objective of this study was to analyze the impact of the time interval (TI) between hysterectomy and initiation of adjuvant radiation treatment (ART) on overall survival (OS) among women with early stage endometrial carcinoma (EC) using the National Cancer Database (NCDB).

Materials And Methods: The NCDB was queried for women with the International Federation of Gynecology and Obstetrics (FIGO) stage I to II EC who underwent hysterectomy followed by ART. We examined the prognostic impact of TI on OS using the cutoff ≤8 or >8 weeks to initiate radiation treatment (RT). Read More

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http://dx.doi.org/10.1097/COC.0000000000000713DOI Listing

Using a pessary during radiotherapy in reducible pelvic organ prolapse and vaginal cancer: a case report and review of the literature.

J Contemp Brachytherapy 2020 Apr 11;12(2):175-180. Epub 2020 Feb 11.

Department of Radiation Oncology, Hacettepe University Medical School, Ankara, Turkey.

Purpose: Primary vaginal cancer and pelvic organ prolapse (POP) combination is extremely rare. Although definitive chemoradiotherapy (CRT) and brachytherapy (BT) is the standard treatment for advanced stage primary vaginal cancer, there is a limited data about the treatment of primary vaginal cancer combined with POP due to its rarity. In addition, radiotherapy (RT) process may be difficult in these cases and often result in more toxicity. Read More

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http://dx.doi.org/10.5114/jcb.2020.92997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7207234PMC

Inter-observer and intra-observer variability in reporting vaginal dose points for cervical cancer in high-dose-rate brachytherapy.

J Contemp Brachytherapy 2020 Apr 17;12(2):139-146. Epub 2020 Apr 17.

Radiotherapy Department, La Fe Polytechnic and University Hospital, Valencia, Spain.

Purpose: The ICRU 89 recommends reporting a set of vaginal dose points for cervical cancer treatments in order to quantify the goodness of implant. This vaginal dose reporting method for combined external beam radiotherapy and brachytherapy has been adopted by the EMBRACE II study protocol. Large variations in dose between patients and centers have been reported. Read More

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http://dx.doi.org/10.5114/jcb.2020.94494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7207226PMC

One-week vaginal brachytherapy schedule as exclusive adjuvant post-operative treatment in intermediate- and high-intermediate-risk endometrial cancer patients.

J Contemp Brachytherapy 2020 Apr 30;12(2):124-130. Epub 2020 Apr 30.

Radiotherapy Oncology, Department of Medicine and Surgery and Translational Medicine, "Sapienza" University of Rome, S Andrea Hospital, Rome, Italy.

Purpose: The aim of the study was to report survival outcomes and toxicities incidence by using one-week vaginal brachytherapy (VBT) schedule in intermediate- and high-intermediate-risk endometrial cancer patients.

Material And Methods: One hundred and eight patients were treated with exclusive high-dose-rate (HDR) brachytherapy short schedule (7 Gy/fraction/every other day/1 week). Acute and late rectal, urinary, and vaginal toxicities were recorded according to radiation therapy oncology group (RTOG) scores and late effects normal tissue task force - subjective, objective, management, analytic (LENT-SOMA) scores, respectively. Read More

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http://dx.doi.org/10.5114/jcb.2020.94581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7207237PMC

Detection of transformation zone cells in liquid-based cytology and its comparison with conventional smears.

Diagn Cytopathol 2020 May 11. Epub 2020 May 11.

Department of Gynecology and Obstetrics, Santa Casa of São Paulo Medical School, Sao Paulo, Brazil.

Background: To compare the differences between liquid-based cytology (LBC) and conventional cytology in respect of the detection of transformation zone cells (TZC) by age group and to assess test performance by correlating results with cytological abnormalities.

Methods: A retrospective study assessing the results of cervical-vaginal cytology smears collected at a private laboratory in São Paulo (Brazil) between January 2010 and December 2015.

Results: A total of 1 030 482 cytology tests were performed; of these, 3811 (0. Read More

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http://dx.doi.org/10.1002/dc.24468DOI Listing

Indication-Specific Opioid Prescribing for US Patients With Medicaid or Private Insurance, 2017.

JAMA Netw Open 2020 May 1;3(5):e204514. Epub 2020 May 1.

National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, Atlanta, Georgia.

Importance: Although opioids can be effective medications in certain situations, they are associated with harms, including opioid use disorder and overdose. Studies have revealed unexplained prescribing variation and prescribing mismatched with patient-reported pain for many indications.

Objective: To summarize opioid prescribing frequency, dosages, and durations, stratified across numerous painful medical indications. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.4514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215258PMC

Sexual function after voluntary medical male circumcision for human immunodeficiency virus prevention: Results from a programmatic delivery setting in Botswana.

South Afr J HIV Med 2020 20;21(1):1042. Epub 2020 Apr 20.

Department of Global Health, University of Washington, Seattle, United States.

Background: Uptake of voluntary medical male circumcision (VMMC) remains modest in Botswana in spite of the government's commitment and service provision availability. Data on sexual function post-VMMC in programmatic settings could help guide messaging tailored to Botswana.

Objectives: At 3-month post-VMMC, we evaluated changes in sexual function and satisfaction with the VMMC procedure amongst a cohort of HIV-negative, sexually active men aged 18-49 years who underwent VMMC in a public-sector clinic in Botswana. Read More

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http://dx.doi.org/10.4102/sajhivmed.v21i1.1042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203194PMC

A single dose of quadrivalent human papillomavirus (HPV) vaccine is immunogenic and reduces HPV detection rates in young women in Mongolia, six years after vaccination.

Vaccine 2020 Jun 7;38(27):4316-4324. Epub 2020 May 7.

Murdoch Children's Research Institute, 50 Flemington Road, Parkville, Melbourne, Australia; Department of Paediatrics, The University of Melbourne, Parkville, Melbourne, Australia.

Background: Emerging observational evidence suggests a single-dose of human papillomavirus (HPV) vaccine may be protective against vaccine-targeted HPV infection and associated cervical dysplasia. We aimed to demonstrate whether a single dose of quadrivalent HPV (4vHPV) vaccine was immunogenic and reduced HPV detection rates in young women in Mongolia. We also assessed knowledge and attitudes regarding HPV and the HPV vaccine. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.04.041DOI Listing
June 2020
3.624 Impact Factor

Extra-vaginal Bacterial Colonization and Risk for Incident Bacterial Vaginosis in a Population of Women who Have Sex with Men.

J Infect Dis 2020 May 7. Epub 2020 May 7.

Fred Hutchinson Cancer Research Center, Seattle, WA.

Bacterial vaginosis (BV) is a common cause of vaginal discharge and associated with vaginal acquisition of BV-associated bacteria (BVAB). We used quantitative PCR assays to determine if presence or concentrations of BVAB in the mouth, anus, vagina, or labia prior to BV predict risk of incident BV in 72 women who have sex with men. Baseline vaginal and extra-vaginal colonization with Gardnerella spp. Read More

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http://dx.doi.org/10.1093/infdis/jiaa233DOI Listing

Considerations in Human Papillomavirus-Associated Oropharyngeal Cancer Screening: A Review.

JAMA Otolaryngol Head Neck Surg 2020 May 7. Epub 2020 May 7.

Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston.

Importance: The incidence of human papillomavirus (HPV)-positive oropharyngeal cancer (OPC) is anticipated to rise over the next few decades until the effects of prophylactic vaccination are realized, which highlights the potential importance of secondary prevention. The objective of this review is to evaluate the evidence associated with screening for HPV-positive OPC.

Observations: Evaluation of a potential clinical preventive screening service requires characterization of the disease burden, the at-risk target screening population, screening tests, treatment, and screening benefits and harms. Read More

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http://dx.doi.org/10.1001/jamaoto.2019.4811DOI Listing

Composite thermoresponsive hydrogel with auranofin-loaded nanoparticles for topical treatment of vaginal trichomonad infection.

Adv Ther (Weinh) 2019 Dec 30;2(12). Epub 2019 Oct 30.

Department of Medicine, University of California San Diego, La Jolla, California 92093, USA.

is responsible for the most common non-viral sexually-transmitted disease worldwide. Standard treatment is with oral nitro-heterocyclic compounds, metronidazole or tinidazole, but resistance to these drugs is emerging and adverse effects can be problematic. Topical treatment offers potential benefits for increasing local drug concentrations and efficacy, while reducing systemic drug exposure, but no topical strategies are currently approved for trichomoniasis. Read More

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http://dx.doi.org/10.1002/adtp.201900157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202563PMC
December 2019

Changes in the cervical microbiota of cervical cancer patients after primary radio-chemotherapy.

Int J Gynecol Cancer 2020 May 5. Epub 2020 May 5.

Department of Radiooncology, Medical Faculty of the University of Cologne, Cologne, Germany

Objective: Several recent studies have identified a potential interaction between the vaginal microbiota and gynecological cancers, but little is known about the cervical microbiota and its changes during cancer treatment. Therefore, the aim of the study was to evaluate the quantitative and qualitative changes of cervical microbiota in patients undergoing concurrent chemotherapy and radiation treatment for locally advanced cervical cancer.

Methods: Cervical cytobrush samples of 15 cervical patients undergoing chemoradiation treatment were collected 1 day before starting external beam radiation therapy and on the day of the last fraction of brachytherapy. Read More

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http://dx.doi.org/10.1136/ijgc-2019-000801DOI Listing

Creatsas modified vaginoplasty as reconstructive treatment of vaginal stenosis due to vaginal or pelvic radiotherapy.

Int J Gynecol Cancer 2020 May 5. Epub 2020 May 5.

Department of Gynecology Oncology, La Fe University and Polytechnic Hospital, Valencia, Spain.

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http://dx.doi.org/10.1136/ijgc-2020-001310DOI Listing

Outcomes and toxicity after salvage radiotherapy for vaginal relapse of endometrial cancer.

Int J Gynecol Cancer 2020 May 5. Epub 2020 May 5.

Gynecologic Oncology, AC Camargo Cancer Center, Sao Paulo, São Paulo, Brazil.

Objectives: Studies of salvage radiotherapy in locally recurrent endometrial cancer remain limited. The aim of this study was to evaluate the efficacy of salvage radiotherapy for vaginal relapse of endometrial cancer and to explore prognostic factors associated with outcomes.

Methods: We evaluated 30 patients treated with salvage external-beam radiotherapy and/or vaginal brachytherapy for vaginal relapses of endometrial cancer between 2009 and 2018. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001281DOI Listing

Patient-initiated follow-up after treatment for low risk endometrial cancer: a prospective audit of outcomes and cost benefits.

Int J Gynecol Cancer 2020 May 5. Epub 2020 May 5.

Gynaecological Oncology, Somerset NHS Foundation Trust, Taunton, TA1 5DA, United Kingdom

Objective: Recurrence of low-risk endometrioid endometrial cancer is rare, and traditional hospital follow-up has a cost to both the patient and the healthcare system, without evidence of benefit. We examined the uptake of patient-initiated follow-up, pattern of recurrences, and survival for women following surgical treatment of low-risk endometrial cancer and compared estimated costs with hospital follow-up.

Methods: This study was a prospective audit of outcomes following implementation of a patient-initiated follow-up policy in a UK-based gynecological cancer center for women with low-risk endometrial cancer treated surgically (International Federation of Gynecology and Obstetrics (FIGO) stage 1A, G1-2) from January 2010 to December 2015. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001263DOI Listing

Office hysteroscopy in the management of women with postmenopausal bleeding.

Climacteric 2020 May 5:1-7. Epub 2020 May 5.

Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, Italy.

Postmenopausal bleeding (PMB) is a relevant aspect for health-care providers in clinical practice: the first objective is to rule out potential gynecological cancer. The purpose of this narrative review is to evaluate the role of office hysteroscopy in the management of PMB. Office hysteroscopy is a minimally invasive procedure allowing direct visualization of uterine pathology without the need for general anesthesia and the use of an operating room, generating cost savings and greater compliance among patients. Read More

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http://dx.doi.org/10.1080/13697137.2020.1754389DOI Listing

The Effect of Pelvic Floor Muscle Interventions on Pelvic Floor Dysfunction After Gynecological Cancer Treatment: A Systematic Review.

Phys Ther 2020 May 4. Epub 2020 May 4.

School of Primary and Allied Health Care, Faculty of Medicine, Nursing; and Health Sciences, Monash University.

Objective: The aim of this systematic review was to identify, evaluate and synthesize the evidence from studies that have investigated the effect of nonsurgical, nonpharmacological, pelvic floor muscle interventions on any type of pelvic floor dysfunction or health-related quality of life in patients after any type of treatment for gynecological cancer.

Methods: Six electronic databases (Cochrane Library 2018, CINAHL 1982-2018, MEDLINE 1950-2018, EMBASE 1980-2018, PsycINFO 1806-2018, and EMCARE 1995-2018) were systematically searched in June 2018. Reference lists of identified articles were hand searched. Read More

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http://dx.doi.org/10.1093/ptj/pzaa081DOI Listing

Vaginal Dilator and Pelvic Floor Exercises for Vaginal Stenosis, Sexual Health and Quality of Life among Cervical Cancer Patients Treated with Radiation: Clinical Report.

J Sex Marital Ther 2020 May 2:1-15. Epub 2020 May 2.

Departamento de Fisioterapia, Universidade do Estado de Santa Catarina, Florianópolis, Brazil.

This clinical report aimed to evaluate the effectiveness of the combination of vaginal dilator (VD) and pelvic floor muscle exercises (PFME) on vaginal stenosis, sexual health and quality of life among women undergoing radiotherapy treatment for cervical cancer; PFME were instructed prior to radiotherapy with six-month follow-up. An intention-to-treat analysis was performed for the 28 women. At four-months after radiotherapy, most of the women (90. Read More

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http://dx.doi.org/10.1080/0092623X.2020.1760981DOI Listing

Analytical performance of HPV assays on vaginal self-collected vs practitioner-collected cervical samples: the SCoPE study.

J Clin Virol 2020 Apr 18;127:104375. Epub 2020 Apr 18.

VCS Foundation, Carlton South, Victoria, Australia; Department of Obstetrics and Gynaecology, University of Malaya, Kuala Lumpur, Malaysia; Melbourne School of Population and Global Health, University of Melbourne, Parkville, Victoria, Australia.

Background: In the last decade, human papillomavirus (HPV) testing has been evaluated extensively for cervical screening, with studies finding increased sensitivity compared to cytology. Another advantage of HPV based-screening is the ability to test vaginal samples that can be collected by women themselves. Self-collection has the potential to extend cervical screening coverage by increasing participation rates, particularly among women who are under-screened or have never screened. Read More

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http://dx.doi.org/10.1016/j.jcv.2020.104375DOI Listing

Joint report of SBI (Brazilian Society of Infectious Diseases), FEBRASGO (Brazilian Federation of Gynecology and Obstetrics Associations), SBU (Brazilian Society of Urology) and SBPC/ML (Brazilian Society of Clinical Pathology/Laboratory Medicine): recommendations for the clinical management of lower urinary tract infections in pregnant and non-pregnant women.

Braz J Infect Dis 2020 Apr 30. Epub 2020 Apr 30.

Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM), Departamento de Medicina, São Paulo, SP, Brazil.

Urinary tract infection (UTI) is a common condition in women. There is an increased concern on reduction of bacterial susceptibility resulting from wrongly prescribing antimicrobials. This paper summarizes the recommendations of four Brazilian medical societies (SBI - Brazilian Society of Infectious Diseases, FEBRASGO - Brazilian Federation of Gynecology and Obstetrics Associations, SBU - Brazilian Society of Urology, and SBPC/ML - Brazilian Society of Clinical Pathology/Laboratory Medicine) on the management of urinary tract infection in women. Read More

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http://dx.doi.org/10.1016/j.bjid.2020.04.002DOI Listing

A single-arm, prospective trial investigating the effectiveness of a non-hormonal vaginal moisturizer containing hyaluronic acid in postmenopausal cancer survivors.

Support Care Cancer 2020 May 2. Epub 2020 May 2.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Purpose: To assess the feasibility and efficacy of a non-hormonal hyaluronic acid (HLA) vaginal gel in improving vulvovaginal estrogen-deprivation symptoms in postmenopausal women with a history of hormone receptor-positive (HR+) cancer.

Methods: For this single-arm, prospective longitudinal trial, we identified disease-free patients with a history of HR+ breast cancer treated with aromatase inhibitors or HR+ endometrial cancer treated with surgery and postoperative radiation. Participants used HLA daily for the first 2 weeks, and then 3×/week until weeks 12-14; dosage was then increased to 5×/week for non-responders. Read More

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http://dx.doi.org/10.1007/s00520-020-05472-3DOI Listing

Complete Response of Recurrent Small Cell Carcinoma of the Uterine Cervix to Paclitaxel, Carboplatin, and Bevacizumab Combination Therapy.

Case Rep Oncol 2020 Jan-Apr;13(1):373-378. Epub 2020 Apr 9.

Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

We report a case of recurrent small cell carcinoma of the uterine cervix that showed a complete response to paclitaxel, carboplatin, and bevacizumab (TC + Bev) combination therapy. Small cell carcinoma of the uterine cervix is extremely rare, with an incidence of only 1.3% in Japan, and a poor outcome. Read More

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http://dx.doi.org/10.1159/000506446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184850PMC

Multi-institutional validation of the ESMO-ESGO-ESTRO consensus conference risk grouping in Turkish endometrial cancer patients treated with comprehensive surgical staging.

J Obstet Gynaecol 2020 Apr 29:1-7. Epub 2020 Apr 29.

Department of Radiation Oncology, Hacettepe University Medical School, Ankara, Turkey.

In this study, 683 patients with endometrial cancer (EC) after comprehensive surgical staging were classified into four risk groups as low (LR), intermediate (IR), high-intermediate (HIR) and high-risk (HR), according to the recent consensus risk grouping. Patients with disease confined to the uterus, ≥50% myometrial invasion (MI) and/or grade 3 histology were treated with vaginal brachytherapy (VBT). Patients with stage II disease, positive/close surgical margins or extra-uterine extension were treated with external beam radiotherapy (EBRT)±VBT. Read More

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http://dx.doi.org/10.1080/01443615.2020.1737661DOI Listing

Paediatric acute lymphoblastic leukaemia and caesarean section: A report from the United Kingdom Childhood Cancer Study (UKCCS).

Paediatr Perinat Epidemiol 2020 May;34(3):344-349

Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK.

Background: Reports have suggested that children born by caesarean initiated before labour onset may be at increased risk of developing acute lymphoblastic leukaemia (ALL). However, with most data being derived from case-control study interviews, information on the underpinning reasons for caesarean section is sparse, and evidence is conflicting.

Objectives: Use clinical records compiled at the time of delivery to investigate the association between childhood ALL and caesarean delivery; examining timing in relation to labour onset, and reasons for the procedure. Read More

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http://dx.doi.org/10.1111/ppe.12662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216966PMC

Feasibility, Acceptability, and Efficacy of a Community Health Worker-Driven Approach to Screen Hard-to-Reach Periurban Women Using Self-Sampled HPV Detection Test in India.

JCO Glob Oncol 2020 Apr;6:658-666

Screening Group, International Agency for Research on Cancer, Lyon, France.

Purpose: Detection of high-risk human papillomavirus (HPV) in self-collected vaginal samples can significantly improve participation of hard-to-reach women; however, the implementation of such an approach in a real-life setting, especially in countries with limited resources, has certain challenges. Our study aimed to evaluate the feasibility, acceptability, and efficacy of implementing an HPV self-sampling-based approach to screen a socioeconomically disadvantaged, unscreened population with support from community health workers (CHWs) for community mobilization, counseling, and navigation. Different triaging options for HPV-positive women were also assessed. Read More

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http://dx.doi.org/10.1200/GO.20.00061DOI Listing

The management of gynecological complications in long-term survivors after allogeneic hematopoietic cell transplantation-a single-center real-life experience.

Ann Hematol 2020 Jun 28;99(6):1361-1368. Epub 2020 Apr 28.

Department of Hematology and Transplantology, Medical University of Gdansk, Gdansk, Poland.

In everyday gynecological practice, there is an unmet need to manage survivors after allogeneic hematopoietic cell transplantation (allo-HCT). The major gynecological complications include premature ovarian insufficiency (POI), chronic graft-versus-host disease (cGVHD) of the anogenital zone (cGVHDgyn), and secondary neoplasms. Aiming to assess a real-life scale of problems associated with HCT, we performed a detailed analysis of a consecutive series of females after allo-HCT who were referred for a routine gynecological evaluation. Read More

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http://dx.doi.org/10.1007/s00277-020-04034-1DOI Listing

Female genital tract melanoma: Analysis from a regional cancer institute.

Turk J Obstet Gynecol 2020 Mar 6;17(1):46-51. Epub 2020 Apr 6.

Gujarat Cancer and Research Institute, Clinic of Gynae Oncology, Ahmadabad, India.

Objective: Malignant melanoma of the genital tract comprises 3% of all melanomas afflicting females. They are characterized by poor prognosis with 5-year survival of 0-25% and high incidence for distant metastasis. This study was performed to assess various clinical features, treatment options, and thre management of genital melanomas. Read More

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http://dx.doi.org/10.4274/tjod.galenos.2020.44789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171547PMC

Neoadjuvant Chemotherapy Followed by Vaginal Radical Trachelectomy as Fertility-Preserving Treatment for Patients with FIGO 2018 Stage 1B2 Cervical Cancer.

Oncologist 2020 Apr 27. Epub 2020 Apr 27.

Department of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, The Netherlands.

Background: Standard treatment for International Federation of Gynecology and Obstetrics (FIGO) 2018 stage 1B2 cervical cancer (i.e., tumor size between 2 and 4 cm) is a radical hysterectomy (RH) with pelvic lymph node dissection (PLND). Read More

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http://dx.doi.org/10.1634/theoncologist.2020-0063DOI Listing

A phase III study of transdermal granisetron versus oral ondansetron for women with gynecologic cancers receiving pelvic chemoradiation.

Support Care Cancer 2020 Apr 27. Epub 2020 Apr 27.

Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX, 77030, USA.

Purpose: To compare rates of complete response (no emesis, retching, or rescue antiemetics) in the late phase (days 4-7 post-chemotherapy) of cycle 1 between transdermal granisetron and oral ondansetron in cervical, endometrial, or vaginal cancer survivors undergoing chemoradiation at The University of Texas MD Anderson Cancer Center and LBJ Hospital in Houston, TX.

Methods: In this non-blinded parallel design trial, eligible patients received a granisetron patch replaced every 7 days or 8 mg of ondansetron thrice daily continued for 72 h after chemotherapy completion. Data were collected on medication compliance, episodes of chemotherapy-induced nausea and vomiting (CINV), use of rescue antiemetics, and effects of CINV on quality of life. Read More

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http://dx.doi.org/10.1007/s00520-020-05484-zDOI Listing

Use of fluorescence to guide surgical resection in vulvo-vaginal neoplasia: Two case reports.

J Gynecol Obstet Hum Reprod 2020 Apr 23:101768. Epub 2020 Apr 23.

Gynecologic and Breast Oncologic Surgery Department, Georges Pompidou European, Hospital, Paris, France; Paris University, Faculty of Medicine, Paris, France. Electronic address:

We report hereby two cases of fluorescence-guided surgical resection with Indocyanine green in vulvo-vaginal neoplasia. The first case was a 86-year old patient who had a high-grade squamous intraepithelial lesion of the left small lip and on the vulvar fork. After a first incomplete surgery, a second fluorescence-guided vulvectomy was performed with ICG injected intravenously to determine intraoperatively surgical margins. Read More

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http://dx.doi.org/10.1016/j.jogoh.2020.101768DOI Listing

Pregnancies after vaginal radical trachelectomy (RT) in patients with early invasive uterine cervical cancer: results from a single institute.

BMC Pregnancy Childbirth 2020 Apr 25;20(1):248. Epub 2020 Apr 25.

Department of Obstetrics and Gynecology, Sapporo Medical University, S1, W16, Chuou-ku, Sapporo, Hokkaido, 0608543, Japan.

Background: Radical tracheletomy (RT) with pelvic lymphadenectomy has become an option for young patients with early invasive uterine cervical cancer who desire to maintain their fertility. However, this operative method entails a high risk for the following pregnancy due to its radicality.

Methods: We have performed vaginal RT for 71 patients and have experienced 28 pregnancies in 21 patients. Read More

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http://dx.doi.org/10.1186/s12884-020-02949-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183613PMC

Does cervicovaginal cytology have a role in the diagnosis and surveillance of endometrial adenocarcinoma?

Diagn Cytopathol 2020 Apr 25. Epub 2020 Apr 25.

Department of Pathology, Izmir Katip Celebi University Ataturk Teaching and Research Hospital, Izmir, Turkey.

Objective: To examine the role of cervicovaginal cytology in diagnoses and surveillance of the patients with endometrial carcinoma (EC).

Methods: Patients who underwent EC surgery that included a follow-up were reviewed retrospectively. The cohort was limited to the patients who had an available cervical cytology result within 12 months before the primary surgery took place. Read More

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http://dx.doi.org/10.1002/dc.24444DOI Listing

Laparoscopic laterally extended endopelvic resection procedure for gynecological malignancies.

Int J Gynecol Cancer 2020 Apr 23. Epub 2020 Apr 23.

Department of Gynecologic Oncology, University of Palermo, Palermo, Sicilia, Italy.

Objectives: Pelvic side wall infiltration by gynecological malignancies has been considered for a long time an absolute contraindication to curative resection. The development of the laterally extended endopelvic resection (LEER) has challenged this surgical paradigm. Although the LEER has been standardized in open surgery, only small studies have been published about its endoscopic feasibility. Read More

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http://dx.doi.org/10.1136/ijgc-2019-001129DOI Listing