29,188 results match your criteria Vaginal Cancer


Assessment of dose to functional sub-structures in the lower urinary tract in locally advanced cervical cancer radiotherapy.

Phys Med 2019 Feb 13. Epub 2019 Feb 13.

Department of Oncology, Aarhus University Hospital, Nørrebrogade 44, 8000 Aarhus C, Denmark.

Purpose: To provide an analysis of dose distribution in sub-structures that could be responsible for urinary toxicity after Image-Guided Adaptive BrachyTherapy (IGABT) in Locally Advanced Cervical Cancer (LACC).

Methods: 105 LACC patients treated with radiochemotherapy and IGABT were selected. Sub-structures (bladder wall, trigone, bladder neck, urethra) were contoured on IGABT-planning MRIs. Read More

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http://dx.doi.org/10.1016/j.ejmp.2019.01.017DOI Listing
February 2019

Human Papillomavirus Infection in Senegalese Female Sex Workers.

Papillomavirus Res 2019 Feb 13. Epub 2019 Feb 13.

Bacteriology-Virology Laboratory, CHU Aristide le Dantec, Dakar, Senegal.

Objectives: Several studies have documented the HPV genotypes in the Senegalese general population. The objective was to explore the HPV genotype distribution in Senegalese FSWs in order to assess the potential relevance of currently-available vaccines.

Methods: Vaginal swabs samples collected as part of the National Integrated Biological and Behavioral Survey in 14 regions throughout the country were randomly selected for HPV testing using bead-based multiplex genotyping (TS-MPG). Read More

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http://dx.doi.org/10.1016/j.pvr.2019.02.003DOI Listing
February 2019

Pilot Study of Vaginal Microbiome Using QIIME 2™ in Women With Gynecologic Cancer Before and After Radiation Therapy.

Oncol Nurs Forum 2019 Mar;46(2):E48-E59

Emory University.

Objectives: To characterize the vaginal microbiome using QIIME 2™ (Quantitative Insights Into Microbial Ecology 2) in women with gynecologic cancer.

Sample & Setting: 19 women with gynecologic cancer before and after radiation therapy at a comprehensive cancer center in Atlanta, Georgia.

Methods & Variables: This pilot study analyzed vaginal microbiome communities using a microbiome analysis pipeline, beginning with 16S rRNA gene sequencing and processing through use of a bioinformatics pipeline to downstream microbial statistical analysis. Read More

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http://dx.doi.org/10.1188/19.ONF.E48-E59DOI Listing
March 2019
2.830 Impact Factor

Does Male Circumcision Reduce Women's Risk of Sexually Transmitted Infections, Cervical Cancer, and Associated Conditions?

Front Public Health 2019 31;7. Epub 2019 Jan 31.

Department of Urology, University of Washington School of Medicine, Seattle, WA, United States.

Male circumcision (MC) is proven to substantially reduce men's risk of a number of sexually transmitted infections (STIs). We conducted a detailed systematic review of the scientific literature to determine the relationship between MC and risk of STIs and associated conditions in women. Database searches by "circumcision women" and "circumcision female" identified 68 relevant articles for inclusion. Read More

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http://dx.doi.org/10.3389/fpubh.2019.00004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365441PMC
January 2019
1 Read

International radical trachelectomy assessment: IRTA study.

Int J Gynecol Cancer 2019 Feb 13. Epub 2019 Feb 13.

Oncological surgery, Clinica Astorga, Envigado, Colombia.

Background: Radical trachelectomy is considered a viable option for fertility preservation in patients with low-risk, early-stage cervical cancer. Standard approaches include laparotomy or minimally invasive surgery when performing radical trachelectomy.

Primary Objective: To compare disease-free survival between patients with FIGO (2009) stage IA2 or IB1 (≤2cm) cervical cancer who underwent open versus minimally invasive (laparoscopic or robotic) radical trachelectomy. Read More

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http://dx.doi.org/10.1136/ijgc-2019-000273DOI Listing
February 2019

Approach to sexual dysfunction in women with cancer.

Int J Gynecol Cancer 2019 Feb 13. Epub 2019 Feb 13.

Department of Obstetrics and Gynaecology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy.

Sexual dysfunction in female cancer patients remains under-diagnosed and under-treated. As sexual dysfunction is becoming an increasingly common side effect of cancer treatments, it is imperative for healthcare providers and especially gynecologic oncologists to include a comprehensive evaluation of sexual health as a routine part of the workup of such patients. Although most oncologists are not experienced in treating sexual dysfunctions, simple tools can be incorporated into clinical practice to improve the management of these conditions. Read More

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http://dx.doi.org/10.1136/ijgc-2018-000096DOI Listing
February 2019

Association of hormone replacement therapy with increased risk of meningioma in women: A hospital-based multicenter study with propensity score matching.

Asia Pac J Clin Oncol 2019 Feb 13. Epub 2019 Feb 13.

Centre of Systems Medicine, Chinese Academy of Medical Sciences, Beijing, China.

Aim: There is no consensus regarding the association between hormone replacement therapy (HRT) and risk of meningioma so far. We conducted the first study among Chinese female patients to investigate the influence of HRT use on the risk of meningioma.

Methods: We retrospectively collected records of diagnosis of meningioma for women aged 50 years and above during 2011-2016 and dispense of HRT prior to meningioma diagnosis in three tertiary hospitals in China. Read More

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http://doi.wiley.com/10.1111/ajco.13138
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http://dx.doi.org/10.1111/ajco.13138DOI Listing
February 2019
3 Reads

Tenofovir gel for prevention of herpes simplex virus type-2 acquisition: findings from the VOICE Trial.

J Infect Dis 2019 Feb 11. Epub 2019 Feb 11.

Magee-Womens Research Institute, Pittsburgh, PA.

Background: Genital infection with herpes simplex virus type-2 (HSV-2) is common, and increases risk of HIV transmission and acquisition. Pericoital use of tenofovir (TFV) gel provided protection from HSV-2 acquisition in the CAPRISA 004 Study.

Methods: We measured estimate of effect of vaginal TFV 1% gel in preventing HSV-2 acquisition among women in VOICE, randomized, double-blind, placebo-controlled trial assessing daily use of oral and vaginal TFV for HIV-1 pre-exposure prophylaxis. Read More

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http://dx.doi.org/10.1093/infdis/jiz045DOI Listing
February 2019
1 Read

Human Papillomavirus Risk Perceptions Among Young Adult Sexual Minority Cisgender Women and Nonbinary Individuals Assigned Female at Birth.

Perspect Sex Reprod Health 2019 Feb 12. Epub 2019 Feb 12.

Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston.

Context: Some sexual minority women may be less likely than other women to engage in human papillomavirus (HPV) prevention behaviors. Although risk perceptions have been found to be associated with health behaviors, HPV risk perceptions among U.S. Read More

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http://dx.doi.org/10.1363/psrh.12087DOI Listing
February 2019

Acceptability and utilisation of patient-initiated follow-up for endometrial cancer amongst women from diverse ethnic and social backgrounds: A mixed methods study.

Eur J Cancer Care (Engl) 2019 Feb 12:e12997. Epub 2019 Feb 12.

Leicester Cancer Research Centre, University of Leicester, Leicester, UK.

Introduction: A shift in focus towards risk stratification and survivorship in early stage endometrial cancer (EC) has led to the replacement of hospital follow-up (HFU) with patient-initiated follow-up (PIFU) schemes.

Methods: A mixed methods study was undertaken prospectively to investigate utility and patient satisfaction with a newly introduced PIFU scheme.

Results: Two hundred and twenty-eight women were enrolled onto PIFU in the first 18 months, median age 65 years (range 42-90 years). Read More

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http://dx.doi.org/10.1111/ecc.12997DOI Listing
February 2019

Prevalence of human papillomavirus infection of 65,613 women in East China.

BMC Public Health 2019 Feb 11;19(1):178. Epub 2019 Feb 11.

Laboratory of gene amplification, Kingmed Diagnostics, Nanjing, 210043, China.

Background: The infection with human papillomavirus (HPV) is the major cause of genital disease. This study assessed the prevalence and genotype of HPV among outpatient women and healthy women in Jiangsu, East China.

Methods: A total of 65,613 women aged 16-85 years were recruited from Nanjing Kingmed Diagnostics, including 45,736 outpatients and 19,877 healthy women. Read More

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https://bmcpublichealth.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12889-019-6487-9DOI Listing
February 2019
3 Reads

Treatment modalities for recurrent high-grade vaginal intraepithelial neoplasia.

J Gynecol Oncol 2018 Nov 8. Epub 2018 Nov 8.

Department of Gynecologic Oncology, IRCCS National Cancer Institute, Milan, Italy.

Objective: We have investigated outcomes of women presenting with recurrent high-grade vaginal intra-epithelial neoplasia.

Methods: Data of consecutive women diagnosed with recurrent high-grade vaginal intra-epithelial neoplasia after primary treatment(s) were retrieved. Risk of developing new recurrence over the time was assessed using Kaplan-Meier and Cox models. Read More

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http://dx.doi.org/10.3802/jgo.2019.30.e20DOI Listing
November 2018

A Rare Case of Advanced Urethral Diverticular Adenocarcinoma and a Review of Treatment Modalities.

J Investig Med High Impact Case Rep 2019 Jan-Dec;7:2324709619828408

1 Brookdale University Hospitals and Medical Center, New York, NY, USA.

Female urethral diverticular cancer is a very rare entity with only around 100 cases reported so far in literature and accounts for <1% of all malignancies. In this article, we present a 47-year-old African American female with repeated hospital visits for urinary retention, hematuria, and urinary tract infections. Initial computed tomography imaging and cystoscopy was unremarkable except for a distended urinary bladder. Read More

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http://dx.doi.org/10.1177/2324709619828408DOI Listing
February 2019
1 Read

Patterns of practice in palliative radiotherapy for bleeding tumours in the Netherlands; a survey study among radiation oncologists.

Clin Transl Radiat Oncol 2019 Feb 11;15:70-75. Epub 2019 Jan 11.

MAASTRO Clinic, Department of Radiation Oncology, GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands.

Background And Purpose: Palliative radiotherapy (RT) is one of the treatment options for bleeding tumours; a frequent symptom in patients with advanced cancer. The optimal RT schedule is however unclear. This study explores the current pattern of practice of palliative RT for bleeding tumours in the Netherlands. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24056308183011
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http://dx.doi.org/10.1016/j.ctro.2019.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357684PMC
February 2019
2 Reads

The effect of vitamin D and E vaginal suppositories on tamoxifen-induced vaginal atrophy in women with breast cancer.

Support Care Cancer 2019 Feb 7. Epub 2019 Feb 7.

Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: Vaginal atrophy is one of the most common side effects of using tamoxifen in women with breast cancer. Hormone therapy for vaginal atrophy is prohibited in these women. The present study was conducted to investigate the effect of vitamin D and E vaginal suppositories on vaginal atrophy in women with breast cancer receiving tamoxifen. Read More

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http://dx.doi.org/10.1007/s00520-019-04684-6DOI Listing
February 2019
1 Read

Characteristics of adverse events of endocrine therapies among older patients with breast cancer.

Support Care Cancer 2019 Feb 7. Epub 2019 Feb 7.

Breast Oncology Center, Cancer Institute Hospital, Ariake 3-8-31, Koto-ku, Tokyo, 135-8550, Japan.

Purpose: To clarify the profile of adverse events from endocrine therapies in older patients.

Methods: We surveyed 15 subjective symptoms including hot flashes, sweating, knuckle stiffness, knee/shoulder joint pain, limb numbness, lethargy, forgetfulness, depressive state, irritated state, genital bleeding, leukorrhea increase, vaginal dryness, bone fracture, and weight gain by a questionnaire among 2044 patients over 55 years old (total number of answered sheets, 8875) and compared the results according to age (56-69 years old vs. ≥ 70 years old) and type of therapy (aromatase inhibitors (AIs) vs. Read More

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http://dx.doi.org/10.1007/s00520-019-04674-8DOI Listing
February 2019
1 Read

Cervical microbiota in women with cervical intra-epithelial neoplasia, prior to and after local excisional treatment, a Norwegian cohort study.

BMC Womens Health 2019 Feb 6;19(1):30. Epub 2019 Feb 6.

Department of Gynecology and Obstetrics, Østfold Hospital Trust, Kalnes, Norway.

Background: Local treatment for cervical intraepithelial neoplasia (CIN) by Loop Electrosurgical Excision Procedure (LEEP) has been correlated with reproductive morbidity, while the cervicovaginal microbiota is also known to affect the risk of preterm delivery. CIN and treatment by LEEP might change the cervical microbiota. The main aim of this study was to describe the cervical microbiota before and after LEEP and assess its associaton with cone depth and HPV persistence. Read More

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http://dx.doi.org/10.1186/s12905-019-0727-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364458PMC
February 2019
1 Read

Gynecologic cancers and solid organ transplantation.

Am J Transplant 2019 Feb 6. Epub 2019 Feb 6.

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.

Solid organ transplant (SOT) recipients have approximately 2-fold greater risk of developing and dying from a malignancy compared to the general population. Among the gynecologic cancers, including uterine, cervical, vaginal, vulvar, and ovarian, the HPV-related cancers are known to increase among women post-transplantation compared to women in the general population, but less is known about the risk of uterine and ovarian cancers. This review will provide an overview of the epidemiology of gynecologic cancers after SOT, as well as their pathophysiology, management, and specific risk factors. Read More

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http://dx.doi.org/10.1111/ajt.15292DOI Listing
February 2019
2 Reads

Patterns of care and outcomes for women with uterine cancer and ovarian metastases.

Int J Gynecol Cancer 2019 Feb 4;29(2):365-376. Epub 2019 Jan 4.

Columbia University College of Physicians and Surgeons, New York City, New York, USA

Objective: For women with uterine cancer with metastases isolated to the adnexa (stage IIIA) optimal adjuvant therapy is unknown. We performed a population-based analysis to examine the use of chemotherapy, vaginal brachytherapy, and external beam therapy (in women with stage IIIA uterine cancer.

Methods: The National Cancer Database was used to identify women with stage IIIA uterine cancer with ovarian metastasis from 2004 to 2012. Read More

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http://dx.doi.org/10.1136/ijgc-2018-000047DOI Listing
February 2019
1 Read

Cost-effectiveness evaluation of HPV self-testing offered to non-attendees in cervical cancer screening in Switzerland.

Gynecol Oncol 2019 Feb 1. Epub 2019 Feb 1.

Division of Clinical Epidemiology, Geneva University Hospitals, Rue Gabrielle-Perret-Gentil 4, 1205 Geneva, Switzerland.

Objective: About 30% of women who are eligible for cervical cancer (CC) screening remain un-screened or under-screened in Switzerland. HPV testing on self-collected vaginal samples (Self-HPV) has shown to be more sensitive than cytology while also reaching non-attendees. The objective of this study was to explore the cost-effectiveness of offering Self-HPV to non-attendees in Switzerland. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00908258193006
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http://dx.doi.org/10.1016/j.ygyno.2019.01.021DOI Listing
February 2019
6 Reads
3.774 Impact Factor

Detection of pagetoid urothelial intraepithelial neoplasia extending to the vagina by cervical screening cytology: a case report with renewed immunochemical summary.

Diagn Pathol 2019 Feb 2;14(1). Epub 2019 Feb 2.

Department of Diagnostic Pathology and Cytology, Osaka International Cancer Institute Hospital, 3-1-69 Otemae, Chuo-ku, Osaka, 541-8567, Japan.

Background: Pagetoid spread of urothelial carcinoma (UC) to the lower genital tract is quite a rare and diagnostically challenging condition. Pagetoid urothelial intraepithelial neoplasia extending to the vagina is difficult to diagnose, especially in remote recurrences without symptomatic or macroscopic lesions typical to Paget disease. However, its identification by cervical screening cytology is important because UC is often characterized by a long history of relapse. Read More

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http://dx.doi.org/10.1186/s13000-019-0788-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359825PMC
February 2019
3 Reads

Complications and reoperations after laparoscopic radical cystectomy in a Japanese multicenter cohort.

Int J Urol 2019 Feb 1. Epub 2019 Feb 1.

Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Objectives: To describe the complications and their surgical management after laparoscopic radical cystectomy in a Japanese multicenter cohort.

Methods: The participants were drawn from a retrospective multicenter study at 10 institutions. We identified 436 patients who underwent laparoscopic radical cystectomy with no robot assistance. Read More

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http://dx.doi.org/10.1111/iju.13917DOI Listing
February 2019
2 Reads

[TNM classification of gynecologic malignancies : What remains to be done beyond 2017?]

Pathologe 2019 Feb;40(1):73-79

Pathologisches Institut, Ludwig-Maximilians-Universität München, München, Deutschland.

For some gynecologic malignancies, there are disagreements between the most recent WHO and TNM classifications and the recommendations of the International Collaboration of Cancer Reporting. These discrepancies are addressed and discussed in this paper. The WHO definition for primary vaginal cancer does not match the TNM definition. Read More

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http://dx.doi.org/10.1007/s00292-018-0559-yDOI Listing
February 2019
1 Read

[New strategies for the prevention and control of cervical cancer in Chile.]

Salud Publica Mex 2018 Nov-Dic;60(6):713-721

Centro Avanzado de Enfermedades Crónicas ACCDiS, Escuela de Medicina, Pontificia Universidad Católica de Chile. Santiago, Chile.

Objective: To discuss cervical cancer (CC), Human PapillomaVirus (HPV),CC control program and propose alternatives for Chile.

Materials And Methods: We analyzed the national program of CC 1966-2015 and the clinical CC guideline 2015-2020;HPV prevalence in women and in cases of CC; HPV infection and serology; the self-vaginal sample; the accuracy and cost-effectiveness of screening with HPV versus Papanicolaou,and triage options among HPV-AR positives.

Results: 600 women die of CC each year in Chile, mainly from low resources. Read More

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http://dx.doi.org/10.21149/8577DOI Listing

High-grade endometrial stromal sarcoma: a retrospective study of factors influencing prognosis.

Cancer Manag Res 2019 17;11:831-837. Epub 2019 Jan 17.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China,

Objectives: The aim of this study was to evaluate the factors associated with progress-free survival (PFS) and overall survival (OS) in patients with high-grade endometrial stromal sarcoma (HG-ESS).

Patients And Methods: A total of 40 patients were enrolled in this study at the Peking Union Medical College Hospital, Beijing, China, from 2006 to 2016. The study retrospectively analyzed clinical and pathological data, and associations of these variables with PFS and OS were evaluated. Read More

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http://dx.doi.org/10.2147/CMAR.S187849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340498PMC
January 2019
2 Reads

Association between vaginal washing and detection of by culture and quantitative PCR in HIV-seronegative Kenyan women: a cross-sectional analysis.

Sex Transm Infect 2019 Jan 29. Epub 2019 Jan 29.

Department of Epidemiology, University of Washington, Seattle, Washington, USA.

Objectives: Vaginal washing has been associated with reductions in cultivable and an increased risk of both bacterial vaginosis (BV) and HIV infection. The effect of vaginal washing on the quantity of individual species is not well characterised. This analysis tested the hypothesis that vaginal washing would be associated with a lower likelihood of spp. Read More

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http://dx.doi.org/10.1136/sextrans-2018-053769DOI Listing
January 2019
1 Read

Genome-Wide Profiling of Cervical RNA-Binding Proteins Identifies Human Papillomavirus Regulation of RNASEH2A Expression by Viral E7 and E2F1.

MBio 2019 Jan 29;10(1). Epub 2019 Jan 29.

Tumor Virus RNA Biology Section, RNA Biology Laboratory, Center for Cancer Research, NCI/NIH, Frederick, Maryland, USA

RNA-binding proteins (RBPs) control mRNA processing, stability, transport, editing, and translation. We recently conducted transcriptome analyses comparing normal (i.e. Read More

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http://dx.doi.org/10.1128/mBio.02687-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355981PMC
January 2019
2 Reads

[Clinicopathological analysis of cervical basaloid squamous cell carcinoma].

Zhonghua Fu Chan Ke Za Zhi 2019 Jan;54(1):7-12

Department of Pathology, General Hospital of PLA, Beijing 100853, China.

To investigate the clinical and histopathological features of cervical basal squamous cell carcinoma (BSCC). A retrospective analysis of 10 cases of cervical BSCC was carried out. The clinical data and all the pathological sections were reviewed, the related immunohistochemical results were statistically analyzed, the clinicopathological features were analyzed, and then followed the prognosis. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-567x.2019.01.003DOI Listing
January 2019
8 Reads

Radical Cystectomy in Pathological T4a and T4b Bladder Cancer Patients: Is There Any Space for Sub Stratification?

Urol Int 2019 Jan 29:1-8. Epub 2019 Jan 29.

Division of Oncology, Unit of Urology, IRCCS Ospedale San Raffaele, Milan, Italy.

Introduction: According to TNM staging, pathological T4ab are comprehensive of the invasion of prostate, seminal vesicles, uterus or vagina and pelvic or abdominal wall. However, few data are available on the perioperative and oncological outcomes of specific organ invasion.

Materials And Methods: A total of 917 consecutive bladder cancer (BCa) patients treated with radical cystectomy (RC) at a single institution between 1990 and 2015 were studies. Read More

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http://dx.doi.org/10.1159/000493899DOI Listing
January 2019
1 Read

Vaginal Dysplasia and HIV: An African American and Caribbean American Cohort Study.

Interdiscip Perspect Infect Dis 2019 1;2019:6189837. Epub 2019 Jan 1.

Department of Obstetrics and Gynecology, Division of Research and Special Projects Miami, University of Miami Miller School of Medicine, Miami 33101, USA.

Background: Vaginal cancer is a rare disease with poor clinical outcomes and limited therapeutic options. In the United States (US), minority women and older women are disproportionately diagnosed with late-stage vaginal cancer. Sociodemographic characteristics, risk behaviors, and cooccurring conditions are linked to vaginal intraepithelial neoplasia (VaIN). Read More

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http://dx.doi.org/10.1155/2019/6189837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332938PMC
January 2019
2 Reads

[A Case of Laparoscopic Resection for Locally Advanced Primary Rectal Cancer after Neoadjuvant Chemotherapy].

Gan To Kagaku Ryoho 2018 Dec;45(13):1922-1924

Dept. of Gastroenterological Surgery, Hirosaki University School of Medicine.

We treateda 70-year-oldfemale patient with locally advancedrectal cancer accompaniedby metastases to other organs. Three courses of S-1 plus oxaliplatin(SOX)therapy were administered as neoadjuvant chemotherapy(NAC), andthe cancer was subsequently treatedwith laparoscopic rectal resection. She hadvisiteda physician with a chief complaint of melena. Read More

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December 2018

[A Case of Elderly Advanced Rectal Cancer Treated with Abdominoperineal Resection after 16 Months of Chemoradiotherapy].

Gan To Kagaku Ryoho 2018 Dec;45(13):2171-2173

Dept. of Surgery, NTT West Osaka Hospital.

An 81-year-old woman underwent preoperative chemoradiotherapy(CRT)for advanced lower rectal cancer with vaginal invasion. However, she refused surgery and received additional radiotherapy. We detected a rectal-vaginal leak, so we performed ileostomy with double orifices and chemotherapy. Read More

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December 2018
1 Read

Interaction of and vaginolysin with the apical versus basolateral face of a 3-dimensional model of vaginal epithelium.

Infect Immun 2019 Jan 28. Epub 2019 Jan 28.

Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, Virginia, USA

Studies have implicated as an important etiological agent in bacterial vaginosis (BV). It produces a cholesterol-dependent cytolysin, vaginolysin (VLY). In this study, we sought to characterize the interaction between vaginal epithelium, , and VLY using EpiVaginal tissues from MatTek. Read More

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http://dx.doi.org/10.1128/IAI.00646-18DOI Listing
January 2019
2 Reads

Preparedness of Young Girls for Prevention of Cervical Cancer and Strategy to introduce the HPV Vaccine.

Indian J Community Med 2018 Dec;43(Suppl 1):S38-S41

Department of Community Medicine and Family Medicine, AIIMS, Bhubaneswar, Odisha, India.

Objective: Cervical cancer incidence and mortality rates remain high in developing country due to low levels of awareness on preventive measures. The main study objective was to sensitize the young girls on the prevention of cervical cancer.

Study Design: Quasi-experimental pretest and posttest design was used. Read More

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http://dx.doi.org/10.4103/ijcm.IJCM_14_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324042PMC
December 2018
2 Reads

Occult Vaginal Evisceration: Case Report.

J Obstet Gynaecol Can 2019 Jan 24. Epub 2019 Jan 24.

Division of Urogynecology and Pelvic Reconstructive Surgery, Department of Obstetrics and Gynecology, The Ottawa Hospital, Ottawa, ON.

Background: Vaginal evisceration is a rare gynaecologic emergency that necessitates surgical intervention. It may manifest with obvious vaginal rupture, or it may be occult, specifically in patients with chronic pelvic organ prolapse.

Case: A 66-year-old woman with a history of bowel cancer and irradiation presented with occult vaginal evisceration. Read More

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http://dx.doi.org/10.1016/j.jogc.2018.11.025DOI Listing
January 2019
1 Read

Patterns of recurrence and prognosis in locally advanced FIGO stage IB2 to IIB cervical cancer: Retrospective multicentre study from the FRANCOGYN group.

Eur J Surg Oncol 2018 Dec 30. Epub 2018 Dec 30.

Department of Gynaecology and Obstetrics, Tenon University Hospital, Assistance Publique des Hôpitaux de Paris (AP-HP), University Pierre and Marie Curie, Paris 6, Institut Universitaire de Cancérologie (IUC), 4 rue de la Chine, 75020, Paris, France; INSERM UMR_S_938, University Pierre et Marie Curie, Paris 6, 27 rue de Chaligny, 75012, Paris, France.

Introduction: Evidence-based data describing patterns of recurrence and prognosis in women with FIGO stage IB2 to IIB locally advanced cervical cancer (LACC) are scarce. The purpose of this study was to analyse patterns of recurrence in LACC and their correlation with prognosis, depending on FIGO stage, lymph node (LN) status and treatment modalities. The endpoints of this study were the type of recurrence (locoregional or distant, and time to recurrence), the recurrence free survival, the overall survival and the cumulative incidence for both locoregional and distant recurrence. Read More

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http://dx.doi.org/10.1016/j.ejso.2018.11.014DOI Listing
December 2018
3 Reads

Extracellular overproduction of E7 oncoprotein of Iranian human papillomavirus type 16 by genetically engineered Lactococcus lactis.

BMC Biotechnol 2019 Jan 24;19(1). Epub 2019 Jan 24.

Department of Food Hygiene, Faculty of Veterinary Sciences, Science and Research Branch, Islamic Azad University, Tehran, IR, Iran.

Background: We aimed at constructing Lactococcus lactis strains expressing HPV-16 recombinant E7 (rE7) oncoprotein and examining its overproduction ability followed by optimizing batch and fed-batch fermentations. Thereafter, in order to assess the immunogenicity of recombinant L. lactis cells, C57BL/6 mice were immunized by oral gavage. Read More

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http://dx.doi.org/10.1186/s12896-019-0499-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346575PMC
January 2019
2.034 Impact Factor

Detecting recurrent ovarian cancer: revisit the values of whole-body CT and serum CA 125 levels.

Acta Radiol 2019 Jan 24:284185118822649. Epub 2019 Jan 24.

1 Department of Medical Imaging and Intervention, Imaging Core Lab, Institute for Radiological Research, Chang Gung Memorial Hospital at Linkou and Chang Gung University, Taoyuan, Taiwan.

Background: Computed tomography (CT) has served as the first-line imaging modality but its role for detecting recurrent ovarian cancer should be revisited in the era of whole-body CT.

Purpose: To study anatomical distributions and imaging patterns of recurrent ovarian epithelial cancer through whole-body CT and their associations with serum cancer antigen 125 (CA 125) levels.

Material And Methods: This retrospective study approved by the institutional review board comprised a cohort of 497 patients with ovarian cancer. Read More

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http://dx.doi.org/10.1177/0284185118822649DOI Listing
January 2019
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1.350 Impact Factor

Topical treatment of vaginal dryness with a non-hormonal cream in women undergoing breast cancer treatment - An open prospective multicenter study.

PLoS One 2019 24;14(1):e0210967. Epub 2019 Jan 24.

DR. AUGUST WOLFF GmbH & CO. KG-ARZNEIMITTEL, Bielefeld, Germany.

This open, prospective, multicenter, observational study was performed to investigate the efficacy and safety of a non-hormonal cream in women undergoing breast cancer treatment and experiencing vulvovaginal dryness symptoms. Overall, 128 patients from 22 study centers participated. The cream was applied to the vagina and vulva for 28 days. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210967PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345451PMC
January 2019

Association between vaginal washing and vaginal bacterial concentrations.

PLoS One 2019 24;14(1):e0210825. Epub 2019 Jan 24.

Department of Medicine, University of Washington, Seattle, WA, United States of America.

Vaginal washing is a common practice associated with adverse outcomes including bacterial vaginosis (BV) and HIV infection. Prior studies have not examined the associations between vaginal washing and individual vaginal bacteria, or whether these associations are independent of the effect of vaginal washing on BV. The purpose of this study was to characterize the association between vaginal washing and the presence and concentrations of vaginal bacteria associated with optimal and sub-optimal vaginal states. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210825PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345501PMC
January 2019
2 Reads

Rationale and design for fractional microablative CO laser versus photothermal non-ablative erbium:YAG laser for the management of genitourinary syndrome of menopause: a non-inferiority, single-blind randomized controlled trial.

Climacteric 2019 Jan 24:1-5. Epub 2019 Jan 24.

c First Department of Obstetrics and Gynecology , National and Kapodistrian University of Athens , Athens , Greece.

Genitourinary syndrome of menopause (GSM) is a common condition affecting up to 50% of postmenopausal women and up to 70% of postmenopausal breast cancer survivors. GSM is a chronic condition with a significant impact on sexual health and quality of life. The mainstay of treatment has been with symptomatic relief using topical emollients or lubricants. Read More

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https://www.tandfonline.com/doi/full/10.1080/13697137.2018.1
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http://dx.doi.org/10.1080/13697137.2018.1559806DOI Listing
January 2019
3 Reads

Systematic review and evidence synthesis of non-cervical human papillomavirus-related disease health system costs and quality of life estimates.

Sex Transm Infect 2019 Feb 21;95(1):28-35. Epub 2018 Sep 21.

National Infection Service, Public Health England, London, UK

Background: Many economic evaluations of human papillomavirus vaccination should ideally consider multiple disease outcomes, including anogenital warts, respiratory papillomatosis and non-cervical cancers (eg, anal, oropharyngeal, penile, vulvar and vaginal cancers). However, published economic evaluations largely relied on estimates from single studies or informal rapid literature reviews.

Methods: We conducted a systematic review of articles up to June 2016 to identify costs and utility estimates admissible for an economic evaluation from a single-payer healthcare provider's perspective. Read More

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http://sti.bmj.com/lookup/doi/10.1136/sextrans-2018-053606
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http://dx.doi.org/10.1136/sextrans-2018-053606DOI Listing
February 2019
4 Reads

Understanding of risk factors for the human papillomavirus (HPV) infection based on gender and race.

Sci Rep 2019 Jan 22;9(1):297. Epub 2019 Jan 22.

Harvard Medical School, The Massachusetts Eye and Ear Infirmary, Department of Otolaryngology, Boston, MA, 02114, USA.

This study assessed if race and gender predict known sexual risk factors associated with HPV. Data (n = 301) were from a cross-sectional study conducted at a drag racing event on September 12-13, 2015 in Madison, Illinois. Both multivariable logistic and linear regression models estimated the association between race, gender, and sexual risk factors. Read More

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http://www.nature.com/articles/s41598-018-36638-z
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http://dx.doi.org/10.1038/s41598-018-36638-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342910PMC
January 2019
3 Reads

Epithelioid Trophoblastic Tumors: Treatments, Outcomes, and Potential Therapeutic Targets.

J Cancer 2019 1;10(1):11-19. Epub 2019 Jan 1.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, PR China.

Epithelioid trophoblastic tumors (ETTs) are the rarest type of gestational trophoblastic neoplasias. We investigated the clinical features, treatments, outcomes, and prognostic factors in patients with ETT, and explored potential therapeutic targets. We retrospectively analyzed the clinical features, treatments, survival, and prognostic factors of 21 ETT patients treated at our institution between January 2002 and December 2017. Read More

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http://dx.doi.org/10.7150/jca.28134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329873PMC
January 2019
9 Reads

Vaginal toxicity after high-dose-rate endovaginal brachytherapy: 20 years of results.

J Contemp Brachytherapy 2018 Dec 28;10(6):559-566. Epub 2018 Dec 28.

Department of Radiotherapy, Alessandro Manzoni Hospital, Lecco.

Purpose: To evaluate vaginal toxicity (primary endpoint) and local control (secondary endpoint) in patients with endometrial cancer who underwent primary surgery and adjuvant high-dose-rate (HDR) endovaginal brachytherapy (BT).

Material And Methods: In September 2017, the authors conducted a comprehensive literature search of the following electronic databases: PubMed, Web of Science, Scopus, and Cochrane library. In this systematic review, the authors included randomized trials, non-randomized trials, prospective studies, retrospective studies, and cases. Read More

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https://www.termedia.pl/doi/10.5114/jcb.2018.79713
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http://dx.doi.org/10.5114/jcb.2018.79713DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335557PMC
December 2018
24 Reads

The anatomical structure of the paravesico-vaginal space, a novel landmark for nerve-sparing radical hysterectomy.

Int J Gynecol Cancer 2019 Jan 18. Epub 2019 Jan 18.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Zhongshan Hospital, Fudan University, Shanghai, China

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http://ijgc.bmj.com/lookup/doi/10.1136/ijgc-2018-000068
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http://dx.doi.org/10.1136/ijgc-2018-000068DOI Listing
January 2019
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Vaginal hysterectomy with or without bilateral salpingo-oophorectomy may be an alternative treatment for endometrial cancer patients with medical co-morbidities precluding standard surgical procedures: a systematic review.

Int J Gynecol Cancer 2019 Jan 18. Epub 2019 Jan 18.

Department of Obstetrics and Gynecology, University Medical Center Groningen, Groningen, The Netherlands.

Objective: Vaginal hysterectomy with bilateral salpingo-oophorectomy may be an alternative strategy for patients with low-risk endometrial cancer and medical co-morbidities precluding laparoscopic or abdominal procedures. The current study evaluates the prevalence of co-existent ovarian malignancy in patients with endometrial cancer and the influence of bilateral salpingo-oophorectomy on survival outcomes in these patients.

Methods: Medline and EMBASE were searched for studies published between January 1, 2000 and November 20, 2017 that investigated (1) the prevalence of co-existing ovarian malignancy (either metastases or primary synchronous ovarian cancer in women with endometrial cancer, and (2) the influence of bilateral salpingo-oophorectomy on recurrence and/or survival rates. Read More

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http://dx.doi.org/10.1136/ijgc-2018-000015DOI Listing
January 2019
3 Reads

Analysis of uterine corporeal mesenchymal tumors occurring after menopause.

BMC Womens Health 2019 Jan 18;19(1):13. Epub 2019 Jan 18.

Department of Obstetrics and Gynecology, Yokohama Municipal Citizen's Hospital, 56 Okazawa-cho, Hodogaya-ku, Yokohama, 240-8555, Japan.

Objective: Because it is difficult to diagnose accurately whether uterine corporeal mesenchymal tumors are benign or malignant before surgery, an understanding of the characteristics of patients with uterine sarcomas occurring in the postmenopausal period is required.

Methods: We retrospectively reviewed the cases of women who underwent surgery for uterine mesenchymal tumors at our hospital.

Results: Among 487 operated cases, 447 tumors occurred in the premenopausal period and 40 occurred in the postmenopausal period. Read More

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http://dx.doi.org/10.1186/s12905-019-0714-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339291PMC
January 2019
2 Reads

Negative rumours about a vaginal ring for HIV-1 prevention in sub-Saharan Africa.

Cult Health Sex 2019 Jan 18:1-16. Epub 2019 Jan 18.

c Women's Global Health Imperative (WGHI) RTI International , San Francisco , CA , USA.

Rumours may influence health-related behaviours, including the uptake of and adherence to HIV prevention products. This study assessed the safety and effectiveness of a vaginal ring delivering the antiretroviral dapivirine for HIV prevention in Africa. We explored negative rumours about study participation and the vaginal ring amongst study participants and their communities in Malawi, Uganda, South Africa and Zimbabwe. Read More

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http://dx.doi.org/10.1080/13691058.2018.1552989DOI Listing
January 2019
1 Read