29,350 results match your criteria Vaginal Cancer


Increased HPV detection by the use of a pre-heating step on vaginal self-samples analysed by Aptima HPV assay.

J Virol Methods 2019 Apr 16. Epub 2019 Apr 16.

Department of Medical Microbiology, Laboratory Medicine Region Skåne, Lund University, Lund, Sweden. Electronic address:

Background: We recently reported a sensitivity of 85.5% to detect high-grade squamous intraepithelial lesions (HSIL)/adenocarcinoma in situ (AIS)/cancer by the use of self-collected vaginal samples analysed by the Aptima mRNA HPV assay (AHPV).

Objectives: To increase detection of HPV among self-samples. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01660934193011
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http://dx.doi.org/10.1016/j.jviromet.2019.04.015DOI Listing
April 2019
1 Read

Preventive Misconception and Risk Behaviors in a Multinational HIV Prevention Trial.

AJOB Empir Bioeth 2019 Apr 19:1-9. Epub 2019 Apr 19.

b Department of Population Health Sciences , Duke University School of Medicine , Durham , North Carolina , USA.

Background: Some HIV prevention research participants may hold a "preventive misconception" (PM), an overestimate of the probability or level of personal protection afforded by trial participation. However, these reports typically rely upon small, retrospective qualitative assessments that did not use a standardized approach.

Methods: We administered a measure of PM called PREMIS, during Microbicide Trials Network 020-A Study to Prevent Infection with a Ring for Extended Use, a large, multicenter, placebo-controlled, phase III trial evaluating the safety and efficacy of a dapivirine vaginal ring among women at risk for HIV infection in Malawi, South Africa, Uganda, and Zimbabwe. Read More

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https://www.tandfonline.com/doi/full/10.1080/23294515.2019.1
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http://dx.doi.org/10.1080/23294515.2019.1593257DOI Listing
April 2019
1 Read

Comparison of urine, self-collected vaginal swab, and cervical swab samples for detecting human papillomavirus (HPV) with Roche Cobas HPV, Anyplex II HPV, and RealTime HR-S HPV assay.

J Virol Methods 2019 Apr 15;269:77-82. Epub 2019 Apr 15.

Department of Obstetrics and Gynecology, Korea University Guro Hospital, College of Medicine, Korea University, Seoul, Republic of Korea. Electronic address:

Background: Human papillomavirus (HPV) is well established as the main cause of cervical cancer. Non-invasive self-collected urine and vaginal sampling have the potential advantage of increasing patient compliance with cervical cancer screening.

Methods: Self-collected vaginal and urine samples and clinician-collected cervical samples were collected from 101 patients, including 84 patients with high grade squamous intraepithelial lesion and 17 patients with benign ovarian disease. Read More

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http://dx.doi.org/10.1016/j.jviromet.2019.04.012DOI Listing
April 2019
1 Read

Radiation induces changes in toll-like receptors of the uterine cervix of the rat.

PLoS One 2019 18;14(4):e0215250. Epub 2019 Apr 18.

Department of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

Radiotherapy is an important therapeutic approach against cervical cancer but associated with adverse effects including vaginal fibrosis and dyspareunia. We here assessed the immunological and oxidative responses to cervical irradiation in an animal model for radiation-induced cervicitis. Rats were sedated and either exposed to 20 Gy of ionising radiation given by a linear accelerator or only sedated (controls) and euthanized 1-14 days later. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215250PLOS
April 2019
3 Reads

Reproductive outcomes following treatment for a gynecological cancer diagnosis: a systematic review.

J Cancer Surviv 2019 Apr 17. Epub 2019 Apr 17.

Kids Cancer Centre, Sydney Children's Hospital, Sydney, NSW, 2031, Australia.

Purpose: Fertility treatments are available for women diagnosed with a gynecological malignancy, which is important for women who desire a biological family subsequent to treatment. The objective of this study was to report reproductive outcomes following fertility-sparing treatment for a gynaecological cancer.

Methods: Electronic databases were searched to identify studies that reported on reproductive outcomes after treatment for a gynecological malignancy. Read More

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http://link.springer.com/10.1007/s11764-019-00749-x
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http://dx.doi.org/10.1007/s11764-019-00749-xDOI Listing
April 2019
2 Reads

The impact of vaginal dilator use on vaginal stenosis and sexual quality of life in women treated with adjuvant radiotherapy for endometrial cancer.

Strahlenther Onkol 2019 Apr 17. Epub 2019 Apr 17.

Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany.

Background: Despite a lack of evidence and low compliance, current guidelines recommend the use of a vaginal dilator (VD) after pelvic radiotherapy (RT). We analyzed the effect of VD on vaginal stenosis (VS) and its influence on sexual quality of life (QoL) in women treated with adjuvant RT for endometrial cancer (EC).

Methods: Between 2014 and 2015, 56 consecutive patients were instructed to use a VD after completion of treatment. Read More

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http://dx.doi.org/10.1007/s00066-019-01466-1DOI Listing

Syphilitic Cervicitis with Cervical Cancer Presenting as Oropharyngeal Syphilis: A Case Report.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of General Internal Medicine, Akashi Medical Center, Japan.

We herein report a patient with syphilitic cervicitis and cervical cancer presenting as oropharyngeal syphilis. A 31-year-old Japanese woman with a history of unprotected vaginal and oral sex visited our hospital with right submandibular adenomas and erythema in the extremities. The fornix uteri was red, with a nodule noted. Read More

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https://www.jstage.jst.go.jp/article/internalmedicine/advpub
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http://dx.doi.org/10.2169/internalmedicine.2426-18DOI Listing
April 2019
2 Reads

Phase III Trial: Adjuvant Pelvic Radiation Therapy Versus Vaginal Brachytherapy Plus Paclitaxel/Carboplatin in High-Intermediate and High-Risk Early Stage Endometrial Cancer.

J Clin Oncol 2019 Apr 17:JCO1801575. Epub 2019 Apr 17.

17 University of Texas Southwestern Medical Center, Dallas, TX.

Purpose: The primary objective was to determine if vaginal cuff brachytherapy and chemotherapy (VCB/C) increases recurrence-free survival (RFS) compared with pelvic radiation therapy (RT) in high-intermediate and high-risk early-stage endometrial carcinoma.

Patients And Methods: A randomized phase III trial was performed in eligible patients with endometrial cancer. Eligible patients had International Federation of Gynecology and Obstetrics (2009) stage I endometrioid histology with Gynecologic Oncology Group protocol 33-based high-intermediate-risk criteria, stage II disease, or stage I to II serous or clear cell tumors. Read More

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http://dx.doi.org/10.1200/JCO.18.01575DOI Listing
April 2019
1 Read

Sexual frequency and pain in a randomized clinical trial of vaginal estradiol tablets, moisturizer, and placebo in postmenopausal women.

Menopause 2019 Apr 15. Epub 2019 Apr 15.

Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.

Objective: To evaluate the efficacy of two common interventions for bothersome postmenopausal vaginal symptoms on improving sexual frequency and pain.

Methods: This is a post-hoc analysis of data from a 12-week double-blind placebo-controlled trial that randomized postmenopausal women (ages 45-70 years) with moderate-severe genitourinary discomfort to vaginal 10 μg estradiol tablet plus placebo gel (n = 102), placebo tablet plus vaginal moisturizer (n = 100), or dual placebo (n = 100). Outcomes were proportion of sexually active women at 12 weeks, frequency of sexual activity, and pain severity with sexual activity (0-3 scale). Read More

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http://dx.doi.org/10.1097/GME.0000000000001341DOI Listing
April 2019
2 Reads

Partner status moderates the relationships between sexual problems and self-efficacy for managing sexual problems and psychosocial quality-of-life for postmenopausal breast cancer survivors taking adjuvant endocrine therapy.

Menopause 2019 Apr 15. Epub 2019 Apr 15.

Department of Psychiatry and Behavioral Sciences, Duke University, Durham, NC.

Objective: Past studies indicate that >90% of breast cancer survivors taking adjuvant endocrine therapy (AET) experience menopausal symptoms including sexual problems (eg, vaginal dryness, dyspareunia); however, research examining the impact of these problems on quality-of-life is limited. This cross-sectional study examined (1) the impact of sexual problems and self-efficacy for coping with sexual problems (sexual self-efficacy) on quality-of-life (ie, psychosocial quality-of-life and sexual satisfaction), and (2) partner status as a moderator of these relationships.

Methods: Postmenopausal breast cancer survivors taking AET completed measures of sexual problems (Menopause-Specific Quality-of-Life [MENQOL] sexual subscale], sexual self-efficacy, psychosocial quality-of-life (MENQOL psychosocial subscale), and sexual satisfaction (Functional Assessment of Cancer Therapy-General item). Read More

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http://dx.doi.org/10.1097/GME.0000000000001337DOI Listing
April 2019
2 Reads

Feasibility, Acceptability, and Accuracy of vaginal Self-Sampling for Screening Human Papillomavirus Types in Women from Rural Areas in Senegal.

Am J Trop Med Hyg 2019 Apr 15. Epub 2019 Apr 15.

Aix Marseille Université, IRD, AP-HM, MEPHI, IHU Méditerranée Infection, Marseille, France.

Vaginal self-sampling and human papillomavirus (HPV) DNA testing can be useful tools for women with limited access to health care living in sub-Saharan Africa. To assess the feasibility and acceptability of vaginal self-sampling and high-risk HPV prevalence in two villages of central Senegal, women were asked to self-sample vaginal swabs for HPV detection in May, 2016. Vaginal swabs were collected from 133 women and were tested for HPV genotyping. Read More

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http://www.ajtmh.org/content/journals/10.4269/ajtmh.19-0045
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http://dx.doi.org/10.4269/ajtmh.19-0045DOI Listing
April 2019
2 Reads

A patient from Zhejiang, China, with synchronous mucinous metaplasia and neoplasms of the female genital tract: A case report.

J Obstet Gynaecol Res 2019 Apr 16. Epub 2019 Apr 16.

Department of Gynecology, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, China.

Synchronous mucinous metaplasia and neoplasms of the female genital tract (SMMN-FGT) is a rare disease reported by a few scholars without the consensus of diagnosis and treatment. Here we will report a 57-year-old female patient from Zhejiang China who suffered from this disease. She came to our hospital because of a large amount of vaginal discharge. Read More

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http://dx.doi.org/10.1111/jog.13959DOI Listing
April 2019
1 Read

A case of incidental endometrial adenocarcinoma diagnosed in early pregnancy and managed conservatively.

Gynecol Oncol Rep 2019 May 27;28:101-103. Epub 2019 Mar 27.

Department of Gynaecological Oncology, East Suffolk and North Essex NHS Foundation Trust, Ipswich hospital, Suffolk, United Kingdom.

We report a 29-year old nulliparous woman diagnosed with a grade 1 endometrioid adenocarcinoma of the endometrium arising from an atypical polypoid adenomyoma, while being investigated for a suspected threatened miscarriage at 7 weeks gestation. She presented complaining of vaginal bleeding and a small amount of soft tissue in the cervical os was found and sent for histology. An ultrasound scan was performed, which confirmed an intrauterine ongoing pregnancy. Read More

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http://dx.doi.org/10.1016/j.gore.2019.03.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449706PMC
May 2019
1 Read

The Effect of Prognostic Factors and Adjuvant Radiotherapy on Survival in Patients with High-Grade Early-Stage Endometrial Cancer: A Retrospective Clinical Study.

Med Sci Monit 2019 Apr 17;25:2811-2818. Epub 2019 Apr 17.

Gynecology and Obstetrics Clinic, Adana Seyhan State Hospital, Adana, Turkey.

BACKGROUND This retrospective clinical study aimed to investigate the effect of prognostic factors and adjuvant radiotherapy in patients with high-grade early-stage endometrial cancer on overall survival (OS) and disease-free survival (DFS). MATERIAL AND METHODS The medical records of patients diagnosed with high-grade, early stage (I or II) endometrial adenocarcinoma who had received adjuvant radiotherapy after surgery were reviewed. RESULTS Seventy-nine patients included 39 patients (49. Read More

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https://www.medscimonit.com/abstract/index/idArt/913740
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http://dx.doi.org/10.12659/MSM.913740DOI Listing
April 2019
1 Read

Long-term Breastfeeding in the Prevention of Allergic Rhinitis: Allergic Rhinitis Cohort Study for Kids (ARCO-Kids Study).

Clin Exp Otorhinolaryngol 2019 Apr 18. Epub 2019 Apr 18.

Department of Otorhinolaryngology, Seoul National University College of Medicine, Seoul, Korea.

Objectives: There is a great deal of interest in the possibility that environmental factors may influence the risk of developing allergic rhinitis (AR) in early life. We investigated the simultaneous effects of mode of delivery and duration of breastfeeding on the development of AR in children.

Methods: Data from 1,374 children participating in the Allergic Rhinitis Cohort Study for kids (ARCO-kids study) was analyzed. Read More

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http://dx.doi.org/10.21053/ceo.2018.01781DOI Listing
April 2019
2 Reads

Quantifying institutional resource utilization of adjuvant brachytherapy and intensity-modulated radiation therapy for endometrial cancer via time-driven activity-based costing.

Brachytherapy 2019 Apr 13. Epub 2019 Apr 13.

Department of Radiation Oncology, Arizona Oncology, The US Oncology Network, Tucson, AZ. Electronic address:

Purpose: The purpose of this study was to quantify the cost of resources required to deliver adjuvant radiation therapy (RT) for high- to intermediate-risk endometrial cancer using time-driven activity-based costing (TDABC).

Methods And Materials: Comparisons were made for three and five fractions of vaginal cuff brachytherapy (VCB), 28 fractions of intensity-modulated radiation therapy (IMRT), and combined modality RT (25-fraction IMRT followed by 2-fraction VCB). Process maps were developed representing each phase of care. Read More

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http://dx.doi.org/10.1016/j.brachy.2019.03.003DOI Listing

Intraoperative 360-deg three-dimensional transvaginal ultrasound during needle insertions for high-dose-rate transperineal interstitial gynecologic brachytherapy of vaginal tumors.

J Med Imaging (Bellingham) 2019 Apr 8;6(2):025001. Epub 2019 Apr 8.

University of Western Ontario, School of Biomedical Engineering, London, Ontario, Canada.

Brachytherapy, a type of radiotherapy, may be used to place radioactive sources into or in close proximity to tumors, providing a method for conformally escalating dose in the tumor and the local area surrounding the malignancy. High-dose-rate interstitial brachytherapy of vaginal tumors requires precise placement of multiple needles through holes in a plastic perineal template to deliver treatment while optimizing dose and avoiding overexposure of nearby organs at risk (OARs). Despite the importance of needle placement, image guidance for adaptive, intraoperative needle visualization, allowing misdirected needles to be identified and corrected during insertion, is not standard practice. Read More

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http://dx.doi.org/10.1117/1.JMI.6.2.025001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451200PMC

Isolated Vaginal Recurrence of Early-Stage Rectal Cancer Detected by 18F-FDG PET/CT.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

Department of Nuclear Medicine, Chongqing Three Gorges Central Hospital, Chongqing, China.

The relapses of rectal cancer are most frequently localized in the pelvis, liver, and pelvic and para-aortic lymph nodes and lungs, whereas the vagina is an unusual site. We present here a 60-year-old woman presenting with lower abdominal discomfort 23 months after radical resection of rectal adenocarcinoma. An isolated, solitary, hypermetabolic mass in the right part of the vagina was detected by F-FDG PET/CT. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002573DOI Listing
April 2019
1 Read

Electrical stimulation for neuroregeneration in urology: a new therapeutic paradigm.

Curr Opin Urol 2019 Apr 9. Epub 2019 Apr 9.

Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic.

Purpose Of Review: The present review highlights regenerative electrical stimulation (RES) as potential future treatment options for patients with nerve injuries leading to urological dysfunction, such as urinary incontinence, voiding dysfunction or erectile dysfunction. Additionally, it will highlight the mechanism of nerve injury and regeneration as well as similarities and differences between RES and current electrical stimulation treatments in urology, functional electrical stimulation (FES) and neuromodulation.

Recent Findings: It has been demonstrated that RES upregulates brain-derived neurotrophic factor (BDNF) and its receptor to facilitate neuroregeneration, facilitating accurate reinnervation of muscles by motoneurons. Read More

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http://dx.doi.org/10.1097/MOU.0000000000000632DOI Listing
April 2019
2 Reads

Vaginal dryness: individualised patient profiles, risks and mitigating measures.

EPMA J 2019 Mar 2;10(1):73-79. Epub 2019 Mar 2.

9Radiological clinic, UKB, Rheinische Friedrich-Wilhelms-University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany.

Vaginal dryness (VD) affects both pre- and postmenopausal women at any age. Since the hormonal regulation changes during the climacteric period are considered as being the main course of the VD, affected women prefer not to talk about the problem. However, the problem does exist, and unfortunately if any, relatively minor group in the population possesses the health literacy at sufficient level to understand that VD is a suboptimal health condition which carries a multi-factorial character. Read More

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http://link.springer.com/10.1007/s13167-019-00164-3
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http://dx.doi.org/10.1007/s13167-019-00164-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459457PMC
March 2019
6 Reads

Nine-valent HPV vaccine efficacy against related diseases and definitive therapy: comparison with historic placebo population.

Gynecol Oncol 2019 Apr 11. Epub 2019 Apr 11.

Merck & Co., Inc., Kenilworth, NJ, United States. Electronic address:

Objective: Nine-valent human papillomavirus (9vHPV) vaccine efficacy against disease and cervical surgeries related to all nine vaccine components was assessed compared with a historic placebo population. This was not assessed in the 9vHPV vaccine efficacy trial since the trial was quadrivalent HPV (qHPV) vaccine-controlled, efficacy was measured for the five HPV types covered only by 9vHPV vaccine (HPV31/33/45/52/58), but not the four types covered by both vaccines (HPV6/11/16/18).

Methods: Three international, randomized, double-blind studies were conducted using the same methodology. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.03.253DOI Listing
April 2019
1 Read

Learning curve analysis of transvaginal natural orifice adnexal surgery.

J Minim Invasive Gynecol 2019 Apr 10. Epub 2019 Apr 10.

Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital at Linkou, (Drs. Y.-T. Huang, Wu, Wang and Weng) Taoyuan, Taiwan.

Study Objective: This study was designed to evaluate the learning curve of transvaginal natural orifice surgery (NOS) for adnexal tumors based on the type of procedure (adnexectomy or cystectomy).

Design: Retrospective cohort study.

Setting: Tertiary-care university hospital. Read More

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http://dx.doi.org/10.1016/j.jmig.2019.04.009DOI Listing
April 2019
1 Read

Advances in phytochemical delivery systems for improved anticancer activity.

Biotechnol Adv 2019 Apr 9. Epub 2019 Apr 9.

Lake Erie College of Osteopathic Medicine, 5000 Lakewood Ranch Boulevard, Bradenton, FL 34211, USA. Electronic address:

Natural compounds have significant anticancer pharmacological activities, but often suffer from low bioavailability and selectivity that limit therapeutic use. The present work critically analyzes the latest advances on drug delivery systems designed to enhance pharmacokinetics, targeting, cellular uptake and efficacy of anticancer phytoconstituents. Various phytochemicals, including flavonoids, resveratrol, celastrol, curcumin, berberine and camptothecins, carried by liposomes, nanoparticles, nanoemulsions and films showed promising results. Read More

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http://dx.doi.org/10.1016/j.biotechadv.2019.04.004DOI Listing
April 2019
11 Reads

Cystoscopy at the Time of Hysterectomy for Benign Indications and Delayed Lower Genitourinary Tract Injury.

Obstet Gynecol 2019 Apr 5. Epub 2019 Apr 5.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Northwestern University Feinberg School of Medicine, the Robert H. Lurie Comprehensive Cancer Center, Northwestern University, and the Center for Healthcare Studies, Institute for Public Health in Medicine, Chicago, Illinois; the Division of Minimally Invasive Gynecology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California; and the Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Objective: To compare the rate of delayed 30-day lower genitourinary tract injury in women who underwent cystoscopy at the time of hysterectomy for benign indications to those who did not.

Methods: This was a retrospective cohort study of patients who underwent hysterectomy without a concomitant procedure for prolapse or incontinence for benign pathology with a general obstetrician-gynecologist (ob-gyn) recorded in the National Surgical Quality Improvement Program targeted hysterectomy file between 2015 and 2017. The primary outcome was a delayed lower genitourinary tract injury in the 30 days after hysterectomy. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003192DOI Listing
April 2019
1 Read

Quality of life under extended continuous versus intermittent adjuvant letrozole in lymph node-positive, early breast cancer patients: the SOLE randomised phase 3 trial.

Br J Cancer 2019 Apr 10. Epub 2019 Apr 10.

Quality of Life Office, International Breast Cancer Study Group Coordinating Center and Bern University Hospital, Inselspital, Bern, Switzerland.

Background: In the phase III SOLE trial, the extended use of intermittent versus continuous letrozole for 5 years did not improve disease-free survival in postmenopausal women with hormone receptor-positive breast cancer. Intermittent therapy with 3-month breaks may be beneficial for patients' quality of life (QoL).

Methods: In the SOLE QoL sub-study, 956 patients completed the Breast Cancer Prevention Trial (BCPT) symptom and further QoL scales up to 24 months after randomisation. Read More

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http://www.nature.com/articles/s41416-019-0435-4
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http://dx.doi.org/10.1038/s41416-019-0435-4DOI Listing
April 2019
3 Reads

Sex steroid hormone receptor expression in the vaginal wall in cervical cancer survivors after radiotherapy.

Acta Oncol 2019 Apr 8:1-9. Epub 2019 Apr 8.

d Department of Women's and Children's Health , Karolinska Institutet and University Hospital , Stockholm , Sweden.

Background: Sex steroid hormones and their receptors are important in female sexual function. The aim of this study was to investigate the expression and distribution of estrogen receptor (ER)α, ERβ, G-protein-coupled ER-1 (GPER), androgen receptor (AR), progesterone receptor (PR)A, PRB and connective tissue growth factor (CTGF) in the vaginal wall among women who had been treated for cervical cancer with radiotherapy.

Material And Methods: We included cervical cancer survivors treated with radiotherapy and premenopausal control women of the same age scheduled for benign gynecological surgery. Read More

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http://dx.doi.org/10.1080/0284186X.2019.1598574DOI Listing

Current practice and physicians' opinion about preoperative hair removal as a part of ERAS pathway implementation in gynecology and gynecology-oncology: a NOGGO-AGO survey of 148 gynecological departments in Germany.

Arch Gynecol Obstet 2019 Apr 5. Epub 2019 Apr 5.

Department of Gynecology with Center for Oncological Surgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Virchow Campus Clinic, Charité Medical University, Berlin, Germany.

Purpose: To gather standardized information about current practices and doctors' opinions on preoperative hair removal (PHR) from the surgical site and to evaluate the extent of PHR as one of the elements of enhanced recovery after surgery (ERAS) pathways that is established in the clinical routine in gynecology and gynecology-oncology departments in Germany.

Methods: We performed a nationwide survey among 638 primary, secondary and tertiary health care gynecological departments in Germany. Data were obtained by sending a multiple-choice questionnaire about preoperative management of hair removal. Read More

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http://dx.doi.org/10.1007/s00404-019-05132-wDOI Listing
April 2019
1 Read

Development of a Vaginal Immobilization Device: A Treatment-planning Study of Carbon-ion Radiotherapy and Intensity-modulated Radiation Therapy for Uterine Cervical Cancer.

Anticancer Res 2019 Apr;39(4):1915-1921

Gunma University Heavy Ion Medical Center, Maebashi, Japan.

Aim: We developed a vaginal immobilization device for external radiotherapy in gynaecological malignancies and evaluated its bowel dose-reduction effect during carbon-ion radiotherapy (CIRT) and intensity-modulated radiation therapy (IMRT) in patients with cervical cancer.

Patients And Methods: Computed tomographic images obtained with and without the device in seven patients with cervical cancer were assessed. Treatment plans for CIRT and IMRT were generated, and dose-volume parameters (V, V, V, and D) of the rectum, sigmoidal colon, and bladder were evaluated. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13300DOI Listing
April 2019
2 Reads

SEXUAL FUNCTION AFTER LAPAROSCOPIC VS. TRANSVAGINAL CLOSURE OF THE VAGINAL VAULT AFTER LAPAROSCOPIC HYSTERECTOMY: A SECONDARY ANALYSIS OF A RANDOMIZED TRIAL BY THE ITALIAN SOCIETY OF GYNECOLOGICAL ENDOSCOPY, USING A VALIDATED QUESTIONNAIRE.

J Minim Invasive Gynecol 2019 Apr 2. Epub 2019 Apr 2.

Department of Woman and Child Health, Fondazione Policlinico Gemelli, IRCCS, Rome, Italy.

Objective: The effect of the different types of vaginal cuff closures on post-hysterectomy sexual function has not been investigated in depth. We evaluated if there is a difference between transvaginal vs. a laparoscopic closure after total laparoscopic hysterectomy (TLH) on female sexual function, using a validated questionnaire. Read More

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http://dx.doi.org/10.1016/j.jmig.2019.03.018DOI Listing
April 2019
2 Reads

Defining characteristics of genital health in South African adolescent girls and young women at high risk for HIV infection.

PLoS One 2019 4;14(4):e0213975. Epub 2019 Apr 4.

Institute of Infectious Disease and Molecular Medicine (IDM), University of Cape Town, Cape Town, South Africa.

The genital tract of African women has been shown to differ from what is currently accepted as 'normal', defined by a pH≤4.5 and lactobacilli-dominated microbiota. Adolescent girls and young women (AGYW) from sub-Saharan Africa are at high risk for HIV, and we hypothesized that specific biological factors are likely to be influential. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213975PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448899PMC
April 2019
2 Reads

Overall mortality in men and women in the randomized Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.

J Med Screen 2019 Apr 3:969141319839097. Epub 2019 Apr 3.

Division of Cancer Prevention, National Cancer Institute, NIH, Bethesda, USA.

Objective: To assess the secondary outcome of overall mortality in the randomized Prostate, Lung, Colorectal, and Ovarian cancer screening trial.

Methods: In the Prostate, Lung, Colorectal, and Ovarian trial, subjects were randomized to usual care or intervention. In the intervention arm, men and women received annual chest radiographs and two sigmoidoscopy exams. Read More

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http://dx.doi.org/10.1177/0969141319839097DOI Listing

Topical estrogen prescribing patterns for urogenital atrophy among women with breast cancer: results of a national provider survey.

Menopause 2019 Apr 1. Epub 2019 Apr 1.

Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.

Objective: The aim of the study was to evaluate knowledge, attitudes, and practice patterns of physicians prescribing topical estrogen for women with urogenital atrophy and a history of breast cancer.

Methods: A cross-sectional survey of breast surgeons, urogynecologists, and gynecologists was distributed via their professional societies: the American Society of Breast Surgeons (ASBrS), the American Urogynecologic Society (AUGS), and the Society of Gynecologic Surgeons (SGS). Providers reported level of comfort prescribing vaginal estrogen for urogenital symptoms for women with different categories of breast cancer and current treatment: estrogen receptor (ER) negative, ER positive no longer on endocrine therapy, and ER positive currently on adjuvant endocrine therapy. Read More

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http://dx.doi.org/10.1097/GME.0000000000001311DOI Listing
April 2019
2 Reads

Gabapentin and Cancer Risk: Updated Findings from Kaiser Permanente Northern California.

Perm J 2019 ;23

Division of Research, Oakland, CA.

Context: Epidemiologic analyses of gabapentin use and cancer risk in Kaiser Permanente Northern California were previously carried out in a collaborative study and independently evaluated in a UK database.

Objective: To update these epidemiologic analyses with 7.5 more years of follow-up. Read More

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http://www.thepermanentejournal.org/issues/2019/winter/6950-
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http://dx.doi.org/10.7812/TPP/18-040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380473PMC
January 2019
7 Reads

Primary Clear Cell Carcinoma with no Diethylstilbestrol Exposure; Case Series.

Iran J Med Sci 2019 Mar;44(2):163-167

Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

One of the rare neoplasms of cervix uteri and vagina is clear cell carcinoma; mostly in patients with a positive past medical history of intrauterine diethylstilbestrol (DES) exposure which reveals the importance of other unknown risk factors of gynecologic neoplasms. 2 Asian women referred to the gynecology-oncology department. The first one came with a complaint of prolonged vaginal discharge and the second one with irregular bleeding. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423437PMC

Mature teratoma containing carcinoid tumour arising within a fallopian tube.

BMJ Case Rep 2019 Mar 31;12(3). Epub 2019 Mar 31.

North Bristol NHS Trust, Bristol, UK.

A 52-year-old woman with a background of vaginal hysterectomy for heavy menstrual bleeding underwent an elective laparoscopic adhesiolysis, left salpingo-oophorectomy for left-sided pelvic pain, and a right salpingectomy. Despite a grossly normal appearance, histology revealed a rare presentation of mature teratoma with insular carcinoid tumour arising from the left fallopian tube. Even though the salpingectomy was thought to be curative, the patient underwent a second operation to remove her remaining right ovary as a precaution against malignant spread. Read More

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http://dx.doi.org/10.1136/bcr-2018-227630DOI Listing
March 2019
1 Read

Carcinosarcoma of the uterine cervix: a rare pathological finding originating from mesonephric remnants.

BMJ Case Rep 2019 Mar 31;12(3). Epub 2019 Mar 31.

Gynecology Oncology, Instituto Português de Oncologia do Porto Francisco Gentil, Porto, Portugal.

Carcinosarcoma of the uterine cervix is a very rare tumour that has been described in less than 70 cases in the literature. It is less common compared with carcinosarcoma of the uterine corpus and it can have two origins: the Müllerian ducts and the mesonephric duct remnants. The association of mesonephric carcinoma with a sarcomatous component was reported in only 11 cases, including the following. Read More

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http://dx.doi.org/10.1136/bcr-2018-227050DOI Listing
March 2019
3 Reads

Cervical cancer with bilateral ovarian metastases: case report and review of literature.

BJR Case Rep 2018 Dec 1;4(4):20180047. Epub 2018 Jun 1.

Department of Obstretics and Gynaecology, Aga Khan University Hospital, Nairobi, Kenya.

Cervical cancers only rarely metastasize to the ovaries. Most of the reported cases are in Western and Asian literature and to the best of our knowledge, this is the first case report of cervical cancer presenting with bilateral ovarian metastasis in sub-Saharan Africa. We present a case report of a 44-year-old female with an 8-month history of irregular per vaginal bleeding. Read More

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http://dx.doi.org/10.1259/bjrcr.20180047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438394PMC
December 2018
4 Reads

Nail Squamous Cell Carcinoma: A Hidden High-risk HPV Reservoir for Sexually Transmitted Infections.

J Am Acad Dermatol 2019 Mar 28. Epub 2019 Mar 28.

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.

Human papillomavirus (HPV) causes cervical cancer, anal cancer, vulvar cancer, vaginal cancer, penile cancer and oropharyngeal cancer. SCC in the genital region in particular is recognized to be caused by HPV infection, and intraepithelial lesions of the penis and vulva are termed penile intraepithelial neoplasia (PIN) and vulvar intraepithelial neoplasia (VIN), respectively. Although SCC of the nail apparatus is recognized as being associated with high-risk HPVs, it is not well-known in general medicine, and its analysis has been insufficient. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.03.070DOI Listing
March 2019
2 Reads

Development and validation of a reverse phase HPLC method for SHetA2, a novel anti-cancer drug, in mouse biological samples.

J Pharm Biomed Anal 2019 Mar 18;170:124-131. Epub 2019 Mar 18.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. Electronic address:

SHetA2 is a flexible heteroarotinoid that has the potential to prevent and treat lung, ovarian and cervical cancer without significant toxicity. A simple and reliable high performance liquid chromatographic (HPLC) method was developed to determine SHetA2 concentrations in the lungs, reproductive organs and plasma of mice. SHetA2 was extracted from these biological matrices by solid phase and liquid-liquid extraction in the presence of 4% HPO and acetonitrile followed by filtration through a Captiva filtration plate. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.03.037DOI Listing
March 2019
1 Read

Prevalence of cervical cancer and pre-cancerous lesions among unscreened Women in Kumasi, Ghana.

Medicine (Baltimore) 2019 Mar;98(13):e14600

Department of Pathology, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, Ghana.

Ghana does not have a universal population-based cervical cancer screening program and there is very limited information about the distribution of cervical epithelial cell lesions. This study provides evidence that a moderately high prevalence of cervical cancer and precancerous lesions exists among unscreened women in Kumasi.The prevalence of cervical epithelial cell abnormalities among a cross-section of women attending cervical cancer screening for the first time in a suburb of Ghana from 2011 to 2014 was studied. Read More

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http://dx.doi.org/10.1097/MD.0000000000014600DOI Listing
March 2019
1 Read
5.723 Impact Factor

Extraperitoneal radical trachelectomy with pelvic lymphadenectomy.

Int J Gynecol Cancer 2019 Mar 26. Epub 2019 Mar 26.

Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Japan

Radical trachelectomy combined with pelvic lymphadenectomy has been used to treat patients with early-stage cervical cancer who wish to preserve their fertility. Vaginal, abdominal, laparoscopic, and robotic approaches have been employed during this procedure, but all cause peritoneal damage, which could result in periadnexal adhesion. As periadnexal adhesion can lead to female infertility due to restricted sweeping of the fimbria over the ovary, it is important to minimize peritoneal damage during the fertility-preserving surgery. Read More

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http://dx.doi.org/10.1136/ijgc-2018-000196DOI Listing
March 2019
1 Read

ACOG Committee Opinion No. 774: Opportunistic Salpingectomy as a Strategy for Epithelial Ovarian Cancer Prevention.

Authors:

Obstet Gynecol 2019 Apr;133(4):e279-e284

Opportunistic salpingectomy may offer obstetrician-gynecologists and other health care providers the opportunity to decrease the risk of ovarian cancer in their patients who are already undergoing pelvic surgery for benign disease. By performing salpingectomy when patients undergo an operation during which the fallopian tubes could be removed in addition to the primary surgical procedure (eg, hysterectomy), the risk of ovarian cancer is reduced. Although opportunistic salpingectomy offers the opportunity to significantly decrease the risk of ovarian cancer, it does not eliminate the risk of ovarian cancer entirely. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003164DOI Listing
April 2019
4 Reads

ACOG Committee Opinion No. 774 Summary: Opportunistic Salpingectomy as a Strategy for Epithelial Ovarian Cancer Prevention.

Authors:

Obstet Gynecol 2019 Apr;133(4):842-843

Opportunistic salpingectomy may offer obstetrician-gynecologists and other health care providers the opportunity to decrease the risk of ovarian cancer in their patients who are already undergoing pelvic surgery for benign disease. By performing salpingectomy when patients undergo an operation during which the fallopian tubes could be removed in addition to the primary surgical procedure (eg, hysterectomy), the risk of ovarian cancer is reduced. Although opportunistic salpingectomy offers the opportunity to significantly decrease the risk of ovarian cancer, it does not eliminate the risk of ovarian cancer entirely. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003165DOI Listing
April 2019
2 Reads

Less radical surgery for women with early stage cervical cancer: Our experience on radical vaginal trachelectomy and laparoscopic pelvic lymphadenectomy.

Gynecol Oncol Rep 2019 May 11;28:65-67. Epub 2019 Mar 11.

East Suffolk and North Essex NHS Trust, Ipswich NHS Trust, Gynecological Oncology Department, Heath Road, IP4 5PD Ipswich, Suffolk, England, UK.

We report the use of radical vaginal trachelectomy (RVT) with pelvic laparoscopic lymphadenectomy (LPL) in patients with early stages cervical cancer (FIGO stage IA2-IB1). This is a case series prospectively collected over a 6-year period (2011-2017) at the Ipswich hospital, UK. Cases were compared to a group of women with a similar stage of cervical cancer, but treated with radical hysterectomy (RH) and pelvic lymphadenectomy (PL). Read More

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http://dx.doi.org/10.1016/j.gore.2019.03.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416726PMC
May 2019
1 Read

Autologous Platelet-Released Growth Factor and Sexual Dysfunction Amendment: A Pilot Clinical Trial of Successful Improvement Sexual Dysfunction after Pelvic Irradiation

Asian Pac J Cancer Prev 2019 03 26;20(3):817-823. Epub 2019 Mar 26.

Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Sexual dysfunction (SDF) is a common sequel to cancer treatment which affects the quality of life in women treated with pelvic radiotherapy. The aim of this study was to evaluate the safety, symptom resolution and objective improvement the injection of autologous platelet released growth factor (APRGF) for treatment of SDF in cited patients. This prospective pilot study enrolled 10 cancer-free patients with SDF who underwent pelvic radiotherapy at least 5 years ago, randomly. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.3.817DOI Listing
March 2019
1 Read
1.500 Impact Factor

Predictive factors of severe perioperative morbidity of radical hysterectomy with lymphadenectomy in early-stage cervical cancer: A French prospective multicentric cohort of 248 patients.

Eur J Surg Oncol 2019 04 17;45(4):650-658. Epub 2018 Oct 17.

Gynecologic and Breast Oncologic Surgery Department, Georges Pompidou European, Hospital, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Faculty of Medicine, Paris, France.

Objective: The purpose of this study was to assess the postoperative morbidity after radical hysterectomy (RH) for early-stage cervical cancer and to determine risk factors of severe perioperative morbidity.

Methods: Data of two prospective trials on sentinel node biopsy for cervical cancer (SENTICOL I & II) were analysed. Patients having a radical hysterectomy were included between 2005 and 2012 from 25 French oncologic centers. Read More

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http://dx.doi.org/10.1016/j.ejso.2018.10.057DOI Listing
April 2019
2 Reads

Imaging of gynecological disease: clinical and ultrasound characteristics of uterine sarcomas.

Ultrasound Obstet Gynecol 2019 Mar 25. Epub 2019 Mar 25.

Instituto di Ginecologia e Ostetricia, Università Cattolica del Sacro Cuore, Rome, Italy.

Objective: To describe the clinical and ultrasound characteristics of uterine sarcomas.

Methods: This is a retrospective multicenter study. From the databases of 13 ultrasound centers, we identified patients with a histological diagnosis of uterine sarcoma with available ultrasound reports and ultrasound images who had undergone preoperative ultrasound examination between 1996 and 2016. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/uog.20270
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http://dx.doi.org/10.1002/uog.20270DOI Listing
March 2019
10 Reads

Cervical, Vaginal, and Vulvar Cancer Costs Incurred by the Medicaid Program in Publicly Insured Patients in Texas.

J Low Genit Tract Dis 2019 Apr;23(2):102-109

Department of Management, Policy, and Community Health, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX.

Objectives: To determine from the perspective of the State of Texas, the direct medical care costs associated with cervical, vaginal, and vulvar cancers in Texas Medicaid enrollees.

Materials And Methods: We conducted a case-control study and searched Texas Medicaid databases between 2008 and 2012 for eligible cancer patients. A comparison group was selected for each cancer site using a 2-step 1:1 propensity score matching method. Read More

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http://dx.doi.org/10.1097/LGT.0000000000000472DOI Listing
April 2019
6 Reads
1.110 Impact Factor

Patterns of Failures and Clinical Outcome of Patients with Early-Stage, High-Risk, Node-Negative Endometrial Cancer Treated with Surgery Followed by Adjuvant Platinum-Based Chemotherapy and Vaginal Brachytherapy.

Oncology 2019 Mar 22:1-7. Epub 2019 Mar 22.

Department of Experimental and Clinical Medicine, Division of Gynecology and Obstetrics, University of Pisa, Pisa, Italy.

Objective: To assess the clinical outcome of patients with high-risk early-stage endometrial cancer and negative pelvic nodes who received adjuvant platinum-based chemotherapy plus vaginal brachytherapy (VBT).

Methods: This investigation assessed 80 patients who underwent hysterectomy, bilateral salpingo-oophorectomy, and pelvic lymphadenectomy for stage Ib-II, grade 2-3 endometrioid (n = 43) or stage Ia-II nonendometrioid (n = 37) endometrial cancer.

Results: Five-year local control rate, 5-year disease-free survival, and 5-year overall survival were 97, 87, and 97%, respectively, for endometrioid carcinoma, and 66, 50, and 72%, respectively, for nonendometrioid carcinoma. Read More

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http://dx.doi.org/10.1159/000492430DOI Listing
March 2019
1 Read