615 results match your criteria VIPomas


Symptomatic and radiological response to 177Lu-DOTATATE for the treatment of functioning pancreatic neuroendocrine tumors.

J Clin Endocrinol Metab 2018 Dec 18. Epub 2018 Dec 18.

Department of Internal Medicine, Sector of Endocrinology.

Purpose: Peptide receptor radionuclide therapy (PRRT) with the radiolabeled somatostatin analogue [Lutetium-177-DOTA0-Tyr3]octreotate (177Lu-DOTATATE) is widely applied for inoperable metastatic small intestinal and non-functioning pancreatic neuroendocrine tumors (pNETs). The aim of this study is to describe the safety and efficacy of the treatment of functioning pNETs.

Methods: Patients were treated with up to four cycles of 177Lu-DOTATATE with an intended dose of 7. Read More

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http://dx.doi.org/10.1210/jc.2018-01991DOI Listing
December 2018

Octreotide reverses shock due to vasoactive intestinal peptide-secreting adrenal pheochromocytoma: A case report and review of literature.

World J Clin Cases 2018 Nov;6(14):862-868

Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China.

Vasoactive intestinal peptide-producing tumors (VIPoma) usually originate in the pancreas and are characterized by diarrhea, hypokalemia, and achlorhydria (WDHA syndrome). In adults, nonpancreatic VIPoma is very rare. Herein, we report an unusual case of VIP-producing pheochromocytoma marked by persistent shock, flushing, and watery diarrhea and high sensitivity to octreotide. Read More

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http://dx.doi.org/10.12998/wjcc.v6.i14.862DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264997PMC
November 2018
2 Reads

The impact of failure to achieve symptom control after resection of functional neuroendocrine tumors: An 8-institution study from the US Neuroendocrine Tumor Study Group.

J Surg Oncol 2019 Jan 27;119(1):5-11. Epub 2018 Nov 27.

Division of Surgical Oncology, Department of Surgery, Winship Cancer Institute, Emory University, Atlanta, Georgia.

Background: The goals of resection of functional neuroendocrine tumors (NETs) are two-fold: Oncological benefit and symptom control. The interaction between the two is not well understood.

Methods: All patients with functional NETs of the pancreas, duodenum, and ampulla who underwent curative-intent resection between 2000 and 2016 were identified. Read More

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http://doi.wiley.com/10.1002/jso.25306
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http://dx.doi.org/10.1002/jso.25306DOI Listing
January 2019
9 Reads

Pancreatic VIPomas from China: Case reports and literature review.

Pancreatology 2018 Oct 26. Epub 2018 Oct 26.

Department of General Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.

Vasoactive intestinal polypeptide-secreting tumors (VIPomas) are rare neuroendocrine tumors that often present as watery diarrhea, hypokalemia, and achlorhydria or hypochlorhydria. In this study, we present our institutional experience of diagnosis and treatment of VIPomas, along with a review of the Chinese literature since 1980. Patient #1, diagnosed in 1984 and with intact clinical records, shows the natural history of this disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14243903183070
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http://dx.doi.org/10.1016/j.pan.2018.10.007DOI Listing
October 2018
6 Reads

Perioperative Hypotensive Crisis in an Adolescent with a Pancreatic VIPoma and MEN1-Gene Variant.

Horm Res Paediatr 2018 Oct 16:1-5. Epub 2018 Oct 16.

Division of Endocrinology, Department of Pediatrics, British Columbia Children's Hospital and The University of British Columbia, Vancouver, British Columbia, Canada.

Background: Vasoactive intestinal peptide-secreting tumours (VIPomas) lead to high-volume secretory diarrhoea with hypokalaemia, as well as hyperglycaemia and hypercalcaemia. Diagnosis is often delayed.

Case Description: We present a 13-year-old girl with a distal pancreatic VIPoma diagnosed on her second hospital presentation who became severely hypotensive on anaesthetic induction prior to tumour removal, likely due to the vasodilatory effect of supraphysiological VIP levels. Read More

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https://www.karger.com/Article/FullText/493396
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http://dx.doi.org/10.1159/000493396DOI Listing
October 2018
14 Reads

Results of Duodenopancreatic Reoperations in Multiple Endocrine Neoplasia Type 1.

World J Surg 2019 Feb;43(2):552-558

Department of Visceral-, Thoracic- and Vascular Surgery, Philipps University of Marburg, Baldingerstr, 35043, Marburg, Germany.

Background: To evaluate the outcome of duodenopancreatic reoperations in patients with multiple endocrine neoplasia type 1 (MEN1).

Methods: MEN1 patients who underwent reoperations for duodenopancreatic neuroendocrine neoplasms (dpNENs) were retrieved from a prospective database and retrospectively analyzed.

Results: Twelve of 101 MEN1 patients underwent up to three reoperations, resulting in a total of 18 reoperations for dpNEN recurrence. Read More

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http://link.springer.com/10.1007/s00268-018-4809-1
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http://dx.doi.org/10.1007/s00268-018-4809-1DOI Listing
February 2019
15 Reads

Neoplasms of the Neuroendocrine Pancreas: An Update in the Classification, Definition, and Molecular Genetic Advances.

Adv Anat Pathol 2019 Jan;26(1):13-30

Departments of Pathology, Massachusetts General Hospital, Boston, MA.

This review focuses on discussing the main modifications of the recently published 2017 WHO Classification of Neoplasms of the Neuroendocrine Pancreas (panNEN). Recent updates separate pancreatic neuroendocrine tumors into 2 broad categories: well-differentiated pancreatic neuroendocrine tumors (panNET) and poorly differentiated pancreatic neuroendocrine carcinoma (panNEC), and incorporates a new subcategory of "well-differentiated high-grade NET (G3)" to the well-differentiated NET category. This new classification algorithm aims to improve the prediction of clinical outcomes and survival and help clinicians select better therapeutic strategies for patient care and management. Read More

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http://dx.doi.org/10.1097/PAP.0000000000000201DOI Listing
January 2019
18 Reads

Paediatric VIPoma: A Jamboree of Electrolytes.

Turk J Anaesthesiol Reanim 2018 Apr 29;46(2):158-160. Epub 2017 Nov 29.

Sher-I-Kashmir Institute of Medical Sciences and Associated Hospitals, Srinagar, India.

Vasoactive intestinal peptide secreting tumour (VIPoma) is a rare type of neuroendocrine tumour (NET), primarily located in the tail of pancreas. This type of tumour presents with myriad of metabolic and electrolyte misbalances in the preoperative period, mainly due to increased vasoactive intestinal peptide (VIP) levels. Perioperative management of patients with VIPoma is challenging, especially when dealing with paediatric patients. Read More

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http://dx.doi.org/10.5152/TJAR.2017.22220DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937463PMC
April 2018
3 Reads

[Surgical strategies for small sporadic neuroendocrine pancreatic tumors].

Authors:
K Holzer

Chirurg 2018 Jun;89(6):422-427

Sektionsleitung Endokrine Chirurgie, Klinik für Viszeral‑, Thorax- und Gefäßchirurgie, Universitätsklinikum Marburg, Baldingerstraße, 35043, Marburg, Deutschland.

Small (<2 cm) sporadic neuroendocrine pancreatic neoplasms (pNENs) are a heterogeneous group of neoplasms, which can be separated into functionally active or non-functional tumors. Functionally active pNENs release various hormones, such as insulin, gastrin, glucagon and vasoactive intestinal hormones and therefore lead to severe symptoms independent of their size. The main symptoms include hypoglycemia, coma (insulinoma), diarrhea (gastrinoma, VIPoma), intestinal ulcers (gastrinoma) and hyperglycemia (glucagonoma). Read More

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http://dx.doi.org/10.1007/s00104-018-0632-3DOI Listing
June 2018
2 Reads

[A Surgical Resected Case of VIPoma with Para-Aortic Lymph Node Involvement].

Gan To Kagaku Ryoho 2017 Nov;44(12):1976-1978

Division of Hepato-Biliary-Pancreatic Surgery, Dept. of Surgery, Kobe University Graduate School of Medicine.

A 72-year-old woman had severe watery diarrhea and weight loss. Computed tomography demonstrated a 55mm tumor in pancreatic tail with enlargement of para-aortic lymph nodes. There was no apparent liver metastasis. Read More

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November 2017
4 Reads

[VIPoma : a rare etiology of diarrhea with hypokalemia].

Rev Med Suisse 2018 Jan;14(592):289-293

Service de médecine interne, Hôpital de la Tour, avenue J.-D. Maillard 3, 1217 Genève.

VIPoma or Verner Morrison syndrome is a very rare disease with an incidence rate of 1 case per 10 000 000 person-years. It is a neuroendocrine tumor issue from β-pancreatic islets leading to profuse diarrhea, hypokalemia and gastric achlorydria due to secretion of vasoactive intestinal polypeptide (VIP) hormone. Diagnosis is based on histology of tumor and the dosage of VIP in a blood sample. Read More

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January 2018
4 Reads

Prevalence of O1 serogroup in Assam, India: A hospital-based study.

Indian J Med Res 2017 09;146(3):401-408

Departments of Microbiology, Gauhati Medical College, Guwahati, India.

Background & Objectives: Although cholera remains to be an important public health problem, studies on reliable population-based estimates of laboratory confirmed cholera in endemic areas are limited worldwide. The aim of this hospital-based study was to evaluate the prevalence of Vibrio cholerae serogroup in Assam, India, during 2003-2013.

Methods: Stool samples/rectal swabs were collected from acute watery diarrhoea (AWD) cases during 2003-2013 and processed by standard microbiological procedures. Read More

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http://dx.doi.org/10.4103/ijmr.IJMR_631_15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793477PMC
September 2017
4 Reads

Verner-Morrison syndrome. Literature review.

Rom J Morphol Embryol 2017 ;58(2):371-376

Department of Pediatric Surgery, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania; Department of Neonatology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania;

Chronic diarrhea in infants is a common condition for addressability to pediatric gastroenterologists. The causes are multiple and the delay in reaching the final diagnosis can lead to complications in the general condition of the child. The purpose of this review is to present the bio-clinical and histogenetic particularities of a rare clinical entity, characterized by tumoral causes of chronic diarrhea. Read More

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April 2018
31 Reads

Watery stools and metabolic acidosis.

Intern Emerg Med 2017 Jun 5;12(4):487-492. Epub 2017 Apr 5.

Institute of Internal Medicine and Gastroenterology Area, Fondazione Policlinico Universitario A. Gemelli, Università Cattolica del S. Cuore, Largo Gemelli, 00168, Rome, Italy.

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http://dx.doi.org/10.1007/s11739-017-1656-2DOI Listing
June 2017
11 Reads

Percutaneous Irreversible Electroporation for Pancreatic VIPoma: A Case Report.

Pancreas 2017 01;46(1):135-137

From the *Fuda Cancer Hospital, Jinan University School of Medicine, Guangzhou and †Department of General Surgery, The Second Hospital of Jilin University, Changchun, Jilin, China.

The purpose of this study was to investigate the safety and efficacy of irreversible electroporation (IRE) for the management of unresectable pancreatic vasoactive intestinal peptide tumor (VIPoma) in a 34-year-old male patient. The initial symptom was watery diarrhea, which could not be stopped by fasting. Laboratory tests revealed high vasoactive intestinal peptide (VIP) hormone levels, hypokalemia, and metabolic acidosis. Read More

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http://dx.doi.org/10.1097/MPA.0000000000000698DOI Listing
January 2017
16 Reads

Pancreatic Neuroendocrine Tumor Secreting Vasoactive Intestinal Peptide and Dopamine With Pulmonary Emboli: A Case Report.

J Clin Endocrinol Metab 2016 10 1;101(10):3564-3567. Epub 2016 Sep 1.

Endocrine Oncology Branch (N.N., E.M.F., D.P., E.K.) and Laboratory of Pathology (M.M.Q.), Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.

Context: The vasoactive intestinal peptide-secreting neuroendocrine tumor (VIPoma) is a very rare pancreatic tumor. We report the first case of a patient with VIPoma that co-secreted dopamine and had pulmonary emboli.

Case Description: A 67-year-old woman presented with 2 months of watery diarrhea, severe generalized weakness,6. Read More

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http://dx.doi.org/10.1210/jc.2016-2051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052354PMC
October 2016
16 Reads

Emergency therapy for liver metastases from advanced VIPoma: surgery or transarterial chemoembolization?

Ther Adv Med Oncol 2016 Sep 5;8(5):383-7. Epub 2016 Jul 5.

Department of Gastroenterology and Endoscopy, Hôpital Cochin, Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, AP-HP, Paris, France.

VIPoma is a rare neuroendocrine tumor (NET) with a high potential to develop hepatic metastases and poor prognosis. The primitive tumor is nonsymptomatic and usually localized within the pancreas. Liver metastasis drives the prognosis and induces profuse watery diarrhea or renal failure. Read More

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http://dx.doi.org/10.1177/1758834016656495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4981295PMC
September 2016
28 Reads

Primary Pancreatic Secretinoma: Further Evidence Supporting Secretin as a Diarrheogenic Hormone.

Ann Surg 2017 08;266(2):346-352

*Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH †Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH ‡Department of Surgery, Center for Regenerative Medicine and Cell Based Therapies, Comprehensive Wound Center, Laser Capture Molecular Core, The Ohio State University Wexner Medical Center, Columbus, OH §Division of Gastroenterology, Medical College of Wisconsin, Milwaukee, WI ¶Department of Surgery, University of California at Los Angeles, School of Medicine, Los Angeles, CA ||Department of Surgery, Florida State University, Tallahassee, FL **William and Sheila Konar Center for Digestive and Liver Diseases, Division of Gastroenterology and Hepatology, University of Rochester Medical Center, Rochester, NY.

Objectives: To document the existence of primary pancreatic secretinoma in patients with watery diarrhea syndrome (WDS) and achlorhydria and establish secretin as a diarrheogenic hormone.

Background: Vasoactive intestinal peptide (VIP) has been widely accepted as the main mediator of WDS. However, in 1968, Zollinger et al reported 2 female patients with pancreatic neuroendocrine tumors, WDS, and achlorhydria. Read More

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http://Insights.ovid.com/crossref?an=00000658-201708000-0002
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http://dx.doi.org/10.1097/SLA.0000000000001938DOI Listing
August 2017
25 Reads

Medical management of secretory syndromes related to gastroenteropancreatic neuroendocrine tumours.

Endocr Relat Cancer 2016 09 26;23(9):R423-36. Epub 2016 Jul 26.

Oxford Center for DiabetesEndocrinology and Metabolism, University of Oxford, Oxford, UK.

Although recent epidemiological evidence indicates that the prevalence of non-functioning gastroenteropancreatic (GEP) neuroendocrine tumours (NETs) is rising, a significant number of GEP-NETs still present with symptoms related to the secretion of biologically active substances leading to the development of distinct clinical syndromes. In the past, these syndromes were associated with substantial morbidity and mortality due to the lack of specific therapies; however, since the introduction of long-acting somatostatin analogues and medications such as proton pump inhibitors, their control has been greatly improved. As a result, nowadays, the main cause of morbidity and mortality in GEP-NETs is mostly directly related to tumour growth and the extent of metastatic disease. Read More

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http://dx.doi.org/10.1530/ERC-16-0200DOI Listing
September 2016
12 Reads
4 Citations
4.805 Impact Factor

Pancreatic neuroendocrine tumors: contemporary diagnosis and management.

Hosp Pract (1995) 2016 Aug 18;44(3):109-19. Epub 2016 Jul 18.

a Department of Internal Medicine, Division of Gastroenterology and Hepatology , University of Utah School of Medicine, Huntsman Cancer Center , Salt Lake City , Utah , USA.

Pancreatic neuroendocrine tumors (PNETs) are neoplasms that arise from the hormone producing cells of the islets of Langerhans, also known as pancreatic islet cells. PNETs are considered a subgroup of neuroendocrine tumors, and have unique biology, natural history and clinical management. These tumors are classified as 'functional' or 'non-functional' depending on whether they release peptide hormones that produce specific hormone- related symptoms, usually in established patterns based on tumor subtype. Read More

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http://dx.doi.org/10.1080/21548331.2016.1210474DOI Listing
August 2016
14 Reads

Epidemiological features of gastroenteropancreatic neuroendocrine tumors in Chengdu city with a population of 14 million based on data from a single institution.

Asia Pac J Clin Oncol 2016 Sep 12;12(3):284-8. Epub 2016 May 12.

Department of Gastroenterology, West China Hospital of SiChuan University, ChengDu, SiChuan Province, China.

Aim: Recent studies on gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in the United States as well as the European studies demonstrate an increasing GEP-NETs incidence. Most information on the epidemiology of neuroendocrine tumors comes from western countries. However, the epidemiological profile of GEP-NETs in West China is still unclear. Read More

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http://dx.doi.org/10.1111/ajco.12498DOI Listing
September 2016
23 Reads

Neuroendocrine Differentiation of a Primary BRAF Mutant Colon Cancer in a Patient With a History of Hairy Cell Leukemia.

Clin Colorectal Cancer 2016 12 31;15(4):e235-e239. Epub 2016 Mar 31.

Indiana University Simon Cancer Center, Indianapolis, IN. Electronic address:

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http://dx.doi.org/10.1016/j.clcc.2016.03.006DOI Listing
December 2016
12 Reads

Ventricular fibrillation resulting from electrolyte imbalance reveals vipoma in MEN1 syndrome.

Fam Cancer 2016 10;15(4):645-9

Department of Surgery and Translational Medicine, University of Florence, Largo Brambilla 3, 50139, Florence, Italy.

Sporadic VIPoma is an exceedingly rare tumor with an annual incidence of 1:10 million people worldwide, yet it is described in approximately 5 % of MEN1 patients. The majority of VIPomas are malignant and radical surgery is the best therapeutic option. A 58-year-old man presented with cardiocirculatory arrest due to ventricular fibrillation. Read More

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http://dx.doi.org/10.1007/s10689-016-9906-4DOI Listing
October 2016
16 Reads

Clinical Presentation and Diagnosis of Pancreatic Neuroendocrine Tumors.

Surg Oncol Clin N Am 2016 Apr 18;25(2):363-74. Epub 2016 Feb 18.

Department of Surgery, Helen F. Graham Cancer Center, 4701 Ogletown-Stanton Road, S-4000, Newark, DE 19713, USA.

Pancreatic neuroendocrine tumors are a rare group of neoplasms that arise from multipotent stem cells in the pancreatic ductal epithelium. Although they comprise only 1% to 2% of pancreatic neoplasms, their incidence is increasing. Most pancreatic neuroendocrine tumors are nonfunctioning, but they can secrete various hormones resulting in unique clinical syndromes. Read More

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http://dx.doi.org/10.1016/j.soc.2015.12.003DOI Listing
April 2016
9 Reads

Surgical resection of vasoactive intestinal peptideoma with hepatic metastasis aids symptom palliation: A case report.

Exp Ther Med 2016 Mar 22;11(3):783-787. Epub 2016 Jan 22.

Department of Gastroenterology, Beijing First Hospital of Integrated Chinese and Western Medicine, Beijing 100026, P.R. China.

Vasoactive intestinal peptideoma (VIPoma) is a rare pancreatic endocrine tumor associated with a well-defined clinical syndrome characterized by watery diarrhea, hypokalemia and metabolic acidosis. In adults, VIPoma is most commonly found in the pancreas, with 80% of the tumors occurring in the body and tail and 20% occurring in the pancreatic head. VIPomas can represent a significant diagnostic challenge due to their nonspecific clinical presentation, which can result in the misdiagnosis of a VIPoma as another condition, such as laxative overdose or a carcinoid secreting tumor. Read More

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http://dx.doi.org/10.3892/etm.2016.3019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774344PMC
March 2016
12 Reads

A short history of neuroendocrine tumours and their peptide hormones.

Best Pract Res Clin Endocrinol Metab 2016 Jan 23;30(1):3-17. Epub 2015 Oct 23.

Yale University School of Medicine, New Haven, CT, USA.

The discovery of neuroendocrine tumours of the gastrointestinal tract and pancreas started in 1870, when Rudolf Heidenhain discovered the neuroendocrine cells, which can lead to the development of these tumours. Siegfried Oberndorfer was the first to introduce the term carcinoid in 1907. The pancreatic islet cells were first described in 1869 by Paul Langerhans. Read More

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http://dx.doi.org/10.1016/j.beem.2015.10.004DOI Listing
January 2016
8 Reads

Neuralgic amyotrophy mimicking Vernet syndrome.

J Neurol Sci 2016 Mar 2;362:230-1. Epub 2016 Feb 2.

Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy.

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http://dx.doi.org/10.1016/j.jns.2016.01.064DOI Listing
March 2016
10 Reads

When Symptomatic Treatment Becomes Antitumor Treatment for Vipoma: Opportunity for Frail Elderly Adults.

J Am Geriatr Soc 2016 Feb;64(2):449-50

Department of Geriatrics, Martinique General Hospital, Fort-de-France, France.

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http://dx.doi.org/10.1111/jgs.13968DOI Listing
February 2016
15 Reads

[VIPoma in retroperitoneum of elderly, cause of chronic diarrhea in uncommon location].

Rev Gastroenterol Peru 2015 Oct-Dec;35(4):355-7

Servicio de Endocrinología del Hospital Guillermo Almenara Irigoyen. EsSalud. Lima, Perú.

Chronic secretory diarrhea is a frequent entity. Causes are multiple, that is why reaching final diagnosis can result in delay with complications that this causes in the general condition of the patient. We present the case of one older adult with chronic diarrhea, mild hypokalemia and metabolic hyperchloremic acidosis secondary to a VIPoma in retroperitoneum which is an unusual location of this type of tumor that was diagnosed by biopsy guided by tomography. Read More

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February 2017
6 Reads

Malignant-functioning neuroendocrine tumors of the pancreas: A survival analysis.

Surgery 2016 May 15;159(5):1382-9. Epub 2015 Dec 15.

Endocrine Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.

Background: Malignant-functioning pancreatic neuroendocrine tumors (mFpNETs) are rare. Research analyzing the presentation, biological behavior, and patient outcomes of these tumors is limited.

Methods: We used the Surveillance, Epidemiology, and End Results database to identify patients with malignant insulinomas, gastrinomas, glucagonomas, vasoactive intestinal peptide secreting tumors (VIPomas), somastatinomas, and mixed islet cell tumors (MICTs). Read More

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http://dx.doi.org/10.1016/j.surg.2015.11.010DOI Listing
May 2016
10 Reads

Metastatic VIPoma presenting as an ovarian mass.

Int J Surg Case Rep 2015 23;17:167-9. Epub 2015 Nov 23.

H. Lee Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA. Electronic address:

Introduction: Pancreatic VIPomas are exceedingly rare, with an annual incidence of less than 1 per million. Most VIPomas are metastatic at diagnosis, with the liver being the most common site of spread.

Presentation Of Case: We describe a highly unusual case of a metastatic pancreatic VIPoma to an ovary in a 54 year-old patient. Read More

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http://dx.doi.org/10.1016/j.ijscr.2015.11.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4701860PMC
January 2016
8 Reads

Multiple-phase spiral CT findings of pancreatic vasoactive intestinal peptide-secreting tumor: A case report.

Oncol Lett 2015 Oct 17;10(4):2351-2354. Epub 2015 Aug 17.

Department of Pathology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China.

The present study reports a case of pancreatic vasoactive intestinal peptide-secreting tumor (VIPoma), of 2.2 cm in diameter, arising from the region of the uncus of the pancreas with liver metastases in a 50-year-old patient, which demonstrated unusual multiple-phase spiral computed tomography (MPSCT) results. The pancreatic lesion was isodense compared with the pancreatic parenchyma. Read More

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http://dx.doi.org/10.3892/ol.2015.3615DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580021PMC
October 2015
6 Reads

VIPoma with multiple endocrine neoplasia type 1 identified as an atypical gene mutation.

BMJ Case Rep 2015 Nov 12;2015. Epub 2015 Nov 12.

Department of Diabetology and Nephrology, Ogaki Municipal Hospital, Ogaki, Japan.

A 47-year-old man presented with persistent diarrhoea and hypokalaemia. CT revealed 4 pancreatic tumours that appeared to be VIPomas, because the patient had an elevated plasma vasoactive intestinal polypeptide level. MRI showed a low-intensity area in the pituitary suggestive of a pituitary tumour, and a parathyroid tumour was detected by ultrasonography and 99Tc-MIBI scintigraphy. Read More

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http://dx.doi.org/10.1136/bcr-2015-213016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4654027PMC
November 2015
7 Reads

A 25-Year Experience of Gastroenteropancreatic Neuroendocrine Tumors and Somatostatin (Congeners) Analogs: From Symptom Control to Antineoplastic Therapy.

Front Horm Res 2015 14;44:177-92. Epub 2015 Aug 14.

Department of Internal Medicine, Division of Endocrinology and Metabolism, Holden NCI Designated Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa, USA.

Radioimmunoassay technology was utilized in the discovery of somatostatin and was quickly brought into therapeutics; however, it took the development of somatostatin congeners to solve its limitations of a short half-life. Therapeutic medical control of hyperhormonal states such as acromegaly, carcinoid syndrome and VIPoma significantly advanced from a nonspecific approach to one that specifically and effectively targeted the underlying pathophysiology. Clinical care was transformed from nonspecific symptom control to one of a significant improvement in not only quality of life, but also quantity of life. Read More

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http://dx.doi.org/10.1159/000382146DOI Listing
June 2016
9 Reads

Pancreatic VIPoma visualized by 68Ga DOTA-NOC PET-CT.

Nuklearmedizin 2015 ;54(4):N32-3

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May 2016
5 Reads

Watery diarrhea-hypopotassemia-acidosis syndrome like diarrhea in a case with X-linked lissencephaly with abnormal genitalia.

Authors:
G Tumgor M Agin

Minerva Pediatr 2015 Aug;67(4):379

Cukurova University, School of Medicine, Department of Pediatric Gastroenterology, Adana, Turkey -

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August 2015
6 Reads

Clinical features of pancreatic neuroendocrine tumors.

J Hepatobiliary Pancreat Sci 2015 Aug 17;22(8):578-85. Epub 2015 Feb 17.

Neuroendocrine Tumor Unit, Endocrinology and Metabolism Service, Department of Medicine, Hadassah-Hebrew University Medical Center, P.O.B. 12000, Jerusalem, 91120, Israel.

Pancreatic neuroendocrine tumors (PNETs), also known as islet cell tumors, are rare neoplasms that arise in the endocrine tissues of the pancreas. Most of pancreatic NETs (50-75%) are nonfunctioning (not associated with a hormonal clinical syndrome); however, in up to one third they can secrete a variety of peptide hormones, including insulin, gastrin, glucagon, vasoactive intestinal peptide, somatostatin etc., resulting in rare but unique clinical syndromes. Read More

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http://dx.doi.org/10.1002/jhbp.226DOI Listing
August 2015
8 Reads
3 Citations
2.313 Impact Factor

Intractable and dramatic diarrhea in liver transplantation recipient with vasoactive intestinal peptide-producing tumor after split liver transplantation: a case report.

Transplant Proc 2015 Jan-Feb;47(1):171-3. Epub 2015 Jan 14.

Department of Liver Transplantation Center, West China Hospital of Sichuan University, Sichuan Province, China. Electronic address:

Diarrhea after liver transplantation is a common complication. Vasoactive intestinal peptide-producing tumor (VIPoma) is a rare cause of watery diarrhea; 80% of such tumors occur in the pancreas, but it is rare in liver. Hypersecretion of vasoactive intestinal polypeptide can stimulate intestinal water and electrolyte secretion, and patients with VIPoma present with watery diarrhea, hypokalemia, and dehydration. Read More

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http://dx.doi.org/10.1016/j.transproceed.2014.07.078DOI Listing
October 2015
4 Reads

[Diagnosis and surgical treatment for pancreatic vasoactive intestine polypeptide tumor].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2014 Oct;39(10):1045-8

Department of Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.

Objective: To explore the diagnosis and surgical treatment for pancreatic vasoactive intestine polypeptide tumor (VIPoma).

Methods: Clinical data of 7 patients with VIPoma from Xiangya Hospital, Central South University between January 1990 and July 2011 were collected and analyzed retrospectively.

Results: The different operation modes were selected according to the location of VIPomas, and the postoperative symptoms of all 7 patients were gradually relieved and cured. Read More

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http://dx.doi.org/10.11817/j.issn.1672-7347.2014.10.010DOI Listing
October 2014
7 Reads

Contrast enhanced multi-detector CT and MR findings of a well-differentiated pancreatic vipoma.

World J Radiol 2014 Oct;6(10):840-5

Luigi Camera, Rosa Severino, Simone Maurea, Marco Salvatore, Department of Advanced Biomedical Sciences, Diagnostic Imaging Section, University "Federico II", 80131 Naples, Italy.

Pancreatic vipoma is an extremely rare tumor accounting for less than 2% of endocrine pancreatic neoplasms with a reported incidence of 0.1-0.6 per million. Read More

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http://dx.doi.org/10.4329/wjr.v6.i10.840DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209429PMC
October 2014
9 Reads

A tale of two tumors: treating pancreatic and extrapancreatic neuroendocrine tumors.

Annu Rev Med 2015 17;66:1-16. Epub 2014 Oct 17.

Department of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030; email: ,

Despite their perceived rarity, gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rising in incidence and prevalence. The biology, natural history, and therapeutic options for GEP-NETs are heterogeneous: NETs arising in the pancreas can be distinguished from those arising elsewhere in the gastrointestinal tract, and therapy is dichotomized between these two groups. Somatostatin analogues are the mainstay of oncologic management of bowel NETs; everolimus, streptozocin, and sunitinib are approved to treat pancreatic NETs. Read More

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http://dx.doi.org/10.1146/annurev-med-061813-012908DOI Listing
September 2015
9 Reads

A ten-year retrospective analysis of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in Malaysia.

Med J Malaysia 2014 Jun;69(3):133-7

Universiti Kebangsaan Malaysia Medical Centre, Department of Medicine, Endocrine Unit, Kuala Lumpur, Malaysia.

Gastroenteropancreatic neuroendocrine tumours (GEP- nETs) are rare neoplasms with a complex spectrum of presentation. The study cohort (n=64) included the diagnoses of carcinoid, (n=26, 41%), insulinoma, (n=25, 39%), undetermined (n=10, 16%), VIPoma, glucagonoma and multiple endocrine neoplasia (MEn-1) (n= 3). Almost half of the patients (n=31) had distant metastasis at diagnosis, the commonest being carcinoid tumours. Read More

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http://www.e-mjm.org/2014/v69n3/gastroenteropancreatic-neuro
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June 2014
12 Reads

Sunitinib achieved fast and sustained control of VIPoma symptoms.

Eur J Endocrinol 2015 Jan 10;172(1):K1-3. Epub 2014 Oct 10.

Department of Hepato-Gastroenterology and Digestive OncologyHôpital Robert Debré, Boulevard du Général Koenig, 51100 Reims Cedex, FranceDepartment of Gastroenterology and Digestive OncologyHospices Civils de Lyon, Hôpital Edouard Herriot, Lyon, France

VIPomas are rare-functioning neuroendocrine tumors (NETs). Overproduction of vasointestinal peptide (VIP) leads to the Verner-Morrison syndrome, whose management is challenging when refractory to somatostatin analogs. Two patients with progressive metastatic pancreatic NETs and refractory VIPoma symptoms were treated with sunitinib. Read More

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http://dx.doi.org/10.1530/EJE-14-0682DOI Listing
January 2015
27 Reads

Extra-pancreatic vipoma.

Arq Bras Cir Dig 2014 Jul-Sep;27(3):222-3

Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4676380PMC
May 2015
7 Reads