1,272 results match your criteria Uveitis Juvenile Idiopathic Arthritis


Pediatric Uveitis in a Referral Center in North Part of Turkey.

Ocul Immunol Inflamm 2020 May 28:1-5. Epub 2020 May 28.

Department of Ophthalmology, Ondokuz Mayis University, Samsun, Turkey.

: To analyze the demographic characteristics, clinical features, ocular complications, and visual outcome of pediatric patients with uveitis.: Retrospective evaluation of medical records.: The study included 156 eyes of 93 patients. Read More

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http://dx.doi.org/10.1080/09273948.2020.1758158DOI Listing

Juvenile idiopathic arthritis in Southeast Asia: the Singapore experience over two decades.

Clin Rheumatol 2020 May 16. Epub 2020 May 16.

Department of Pediatric Subspecialties, Rheumatology and Immunology Service, KK Women's and Children's Hospital, Kampong Java, Singapore.

Objectives: To examine the clinical characteristics, treatment and outcomes of juvenile idiopathic arthritis (JIA) patients evaluated in Singapore and compare those with reports elsewhere.

Methods: Patients with JIA were recruited from our Singapore pediatric rheumatology registry from January 1997 to December 2015. Demographic, clinical, treatment, and outcome data were retrospectively collected. Read More

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http://dx.doi.org/10.1007/s10067-020-05081-9DOI Listing

Ophthalmological treatment of early-onset sarcoidosis/Blau syndrome in a Colombian child: A case report.

Am J Ophthalmol Case Rep 2020 Jun 18;18:100714. Epub 2020 Apr 18.

NeURos Research Group. Escuela de Medicina y Ciencias de La Salud, Universidad Del Rosario, Carrera 24 # 63 C 69, Bogotá, Colombia.

Purpose: To report the ophthalmological approach of a patient with Blau syndrome (BS) in Colombia.

Observations: We describe a 9-year-old Colombian boy with sporadic BS due to a nucleotide-binding oligomerization domain containing 2 (NOD2) mutation, who presented with joint and dermatologic symptoms. He was referred to the uveitis service with a single functional eye, due to retinal detachment in the other eye. Read More

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http://dx.doi.org/10.1016/j.ajoc.2020.100714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178324PMC

Results 5 to 10 years after cataract surgery with primary IOL implantation in juvenile idiopathic arthritis-related uveitis.

J Cataract Refract Surg 2020 Apr 24. Epub 2020 Apr 24.

From the Department of Ophthalmology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Purpose: To evaluate the results of cataract extraction with primary intraocular lens (IOL) implantation in patients with juvenile idiopathic arthritis (JIA) and uveitis related cataract.

Setting: Department of Ophthalmology, Helsinki University Hospital, Finland.

Design: Retrospective case series. Read More

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http://dx.doi.org/10.1097/j.jcrs.0000000000000222DOI Listing

Translating IL-6 biology into effective treatments.

Nat Rev Rheumatol 2020 Jun 23;16(6):335-345. Epub 2020 Apr 23.

Laboratory of Immune Regulation, World Premier International Immunology Frontier Research Center, Osaka University, Osaka, Japan.

In 1973, IL-6 was identified as a soluble factor that is secreted by T cells and is important for antibody production by B cells. Since its discovery more than 40 years ago, the IL-6 pathway has emerged as a pivotal pathway involved in immune regulation in health and dysregulation in many diseases. Targeting of the IL-6 pathway has led to innovative therapeutic approaches for various rheumatic diseases, such as rheumatoid arthritis, juvenile idiopathic arthritis, adult-onset Still's disease, giant cell arteritis and Takayasu arteritis, as well as other conditions such as Castleman disease and cytokine release syndrome. Read More

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http://dx.doi.org/10.1038/s41584-020-0419-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7178926PMC

A Rare Case of Juvenile Idiopathic Arthritis following a Ruptured Baker's Cyst in a Toddler.

Case Rep Pediatr 2020 6;2020:1601348. Epub 2020 Apr 6.

Department of Paediatrics, Dr Gray's Hospital, NHS Grampian, Aberdeen, UK.

A Baker's cyst is usually an incidental finding in adults being investigated for a joint arthropathy, and its rupture preceding the diagnosis of juvenile idiopathic arthritis (JIA) is rare in children. Here, we describe a case of a 4-year-old girl who presented to the Emergency Department with right calf pain, swelling, and no preceding history of trauma. MRI confirmed a ruptured Baker's cyst with inflammatory arthropathy alongside an extensive synovial proliferation throughout the knee joint with large joint effusions and associated soft tissue oedema tracking superiorly and inferiorly along the medial head of gastrocnemius and anteriorly along the tibia. Read More

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http://dx.doi.org/10.1155/2020/1601348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165340PMC

Improving quick and accurate diagnosis of childhood JIA-uveitis from a pediatric rheumatology perspective.

Expert Rev Ophthalmol 2020 12;15(2):101-109. Epub 2020 Mar 12.

Cincinnati Children's Hospital Medical Center, Division of Rheumatology, 3333 Burnett Avenue, Cincinnati, Ohio 45229-3026, United States.

Introduction: Juvenile idiopathic arthritis (JIA) is the most common pediatric rheumatic disease associated with uveitis. JIA-associated uveitis (JIA-U) is typically asymptomatic, chronic, and can lead to sight-threatening complications. This review will provide approaches to improve the diagnosis and outcomes of children with JIA-U. Read More

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http://dx.doi.org/10.1080/17469899.2020.1739521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170263PMC

Similarities in clinical course and outcome between juvenile idiopathic arthritis (JIA)-associated and ANA-positive idiopathic anterior uveitis: data from a population-based nationwide study in Germany.

Arthritis Res Ther 2020 Apr 15;22(1):81. Epub 2020 Apr 15.

German Rheumatism Research Center, a Leibniz Institute, Berlin, Germany.

Background: To analyze whether ANA-positive idiopathic anterior uveitis differs from JIA-associated uveitis concerning clinical course, response to treatment, and disease outcome.

Methods: Prospective study of the National Paediatric Rheumatological Database (NPRD) including its uveitis add-on module from the years 2002 to 2016. Cross-sectional data from the years 2002 to 2016 were analyzed. Read More

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http://dx.doi.org/10.1186/s13075-020-02166-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161187PMC

Importance of pediatric rheumatologists and transitional care for juvenile idiopathic arthritis-associated uveitis: a retrospective series of 9 cases.

Pediatr Rheumatol Online J 2020 Mar 23;18(1):26. Epub 2020 Mar 23.

Department of Lifetime Clinical Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan.

Background: Juvenile idiopathic arthritis-associated uveitis (JIA-U) is a serious condition associated with the risk of blindness. However, pediatric rheumatologists rarely encounter cases of blindness, because most patients reach adulthood during the course of follow-up before blindness occurs. Here, we report the progress of 9 patients with JIA-U, including 2 patients who became blind after the transition period. Read More

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http://dx.doi.org/10.1186/s12969-020-0419-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092443PMC

Tocilizumab in patients with anti-TNF refractory juvenile idiopathic arthritis-associated uveitis (APTITUDE): a multicentre, single-arm, phase 2 trial.

Lancet Rheumatol 2020 Mar 7;2(3):e135-e141. Epub 2020 Feb 7.

Department of Women's and Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, UK.

Background: Uveitis associated with juvenile idiopathic arthritis is a cause of major ocular morbidity. A substantial proportion of children are refractory to systemic methotrexate and TNF inhibitors. Our aim was to study the safety and efficacy of tocilizumab in children with juvenile idiopathic arthritis-associated uveitis refractory to both methotrexate and TNF inhibitors. Read More

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http://dx.doi.org/10.1016/S2665-9913(20)30008-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7134526PMC

Evaluation of ocular surface and meibomian glands in patients with uveitis related to oligoarticular juvenile idiopathic arthritis.

Int Ophthalmol 2020 Apr 8. Epub 2020 Apr 8.

Department of Ophthalmology, School of Medicine, Ege University, Bornova, Turkey.

Purpose: To evaluate ocular surface changes and meibomian gland scores in patients with oligoarticular juvenile idiopathic arthritis.

Materials And Methods: This prospective study was conducted at Ege University School of Medicine, Department of Ophthalmology. A total of 34 eyes of 17 patients with oligoarticular juvenile idiopathic arthritis and 30 right eyes of 30 age and gender-matched healthy subjects were included. Read More

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http://dx.doi.org/10.1007/s10792-020-01357-wDOI Listing

Risk of Cataract Development among Children with Juvenile Idiopathic Arthritis-Related Uveitis Treated with Topical Corticosteroids.

Ophthalmology 2020 Apr;127(4S):S21-S26

Department of Epidemiology the Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland; Departments of Ophthalmology and Medicine, the Mount Sinai School of Medicine, NewYork, NewYork.

Purpose: We sought to investigate the risk of cataract development among patients with juvenile idiopathic arthritis (JIA)-associated uveitis treated with topical corticosteroids.

Design: Retrospective cohort study.

Participants: We included 75 patients with JIA-associated uveitis observed from July 1984 through August 2005 at a single academic center. Read More

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http://dx.doi.org/10.1016/j.ophtha.2020.01.036DOI Listing

A Canadian evaluation framework for quality improvement in childhood arthritis: key performance indicators of the process of care.

Arthritis Res Ther 2020 03 19;22(1):53. Epub 2020 Mar 19.

Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Background: The evaluation of quality of care in juvenile idiopathic arthritis (JIA) is critical for advancing patient outcomes but is not currently part of routine care across all centers in Canada. The study objective is to review the current landscape of JIA quality measures and use expert panel consensus to define key performance indicators (KPIs) that are important and feasible to collect for routine monitoring in JIA care in Canada.

Methods: Thirty-seven candidate KPIs identified from a systematic review were reviewed for inclusion by a working group including 3 pediatric rheumatologists. Read More

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http://dx.doi.org/10.1186/s13075-020-02151-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7083048PMC

Prevalence and clinical features of systemic diseases in Chinese patients with uveitis.

Br J Ophthalmol 2020 Mar 18. Epub 2020 Mar 18.

University Eye Clinic Maastricht, Maastricht, The Netherlands.

Purpose: Systemic diseases are frequently associated with uveitis but are often not recognised by clinicians. An estimate of the prevalence in a large-scale uveitis population is essential for understanding the epidemiological profile and may be helpful for clinical practice.

Design: A nationwide survey. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-315960DOI Listing

Enthesitis-related arthritis: prevalence and complications of associated uveitis in children and adolescents from a population-based nation-wide study in Germany.

J Rheumatol 2020 Mar 15. Epub 2020 Mar 15.

From the Department of Ophthalmology at St. Franziskus Hospital, Muenster, Germany; Department of Ophthalmology, University Hospital Essen, Essen, Germany; German Rheumatism Research Center, a Leibniz Institute, Berlin, Germany; Charité-University Medicine Berlin, Institute for Social Medicine, Epidemiology and Health Economics, Berlin, Germany; Charité-University Medicine Berlin, Department of Rheumatology and Clinical Immunology, Berlin, Germany; University of Duisburg-Essen, Germany. Address correspondence to Karoline Walscheid, MD, FEBO, Department of Ophthalmology at St. Franziskus Hospital, Hohenzollernring 74, 48145 Muenster, Germany. email:

Objective: Enthesitis-related arthritis (ERA) represents a subgroup of juvenile idiopathic arthritis (JIA) which is regularly accompanied by anterior uveitis. This study describes the prevalence and characteristics of ERA-related uveitis.

Methods: Cross-sectional data from the National Pediatric Rheumatological Database (NPRD) were used to characterize ERA-related uveitis (ERA-U). Read More

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http://dx.doi.org/10.3899/jrheum.191085DOI Listing

Phenotype of Innate Immune Cells in Uveitis Associated with Axial Spondyloarthritis- and Juvenile Idiopathic Arthritis-associated Uveitis.

Ocul Immunol Inflamm 2020 Mar 11:1-10. Epub 2020 Mar 11.

Department of Ophthalmology, Ophtha-Lab at St. Franziskus Hospital, Münster, Germany.

: To analyze circulating immune cells in patients with anterior uveitis (AU) associated to axial spondyloarthritis (SpA), or juvenile idiopathic arthritis (JIA).: Venous blood samples were collected from healthy controls (n = 16), and either SpA (n = 19) or JIA (n = 23) patients with associated anterior uveitis (AU) during active flare, or after ≥3 months of inactivity. Frequencies of CD56, MHC-I, and S100A9 monocytes, CCR7 dendritic cells, CD56 natural killer (NK) cells and CD3CD56 T-cells were analyzed via flow cytometry. Read More

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http://dx.doi.org/10.1080/09273948.2020.1715449DOI Listing

A Cross-Sectional Online Survey Identifies Subspecialty Differences in the Management of Pediatric Cataracts Associated with Uveitis.

Ophthalmol Ther 2020 Jun 10;9(2):293-303. Epub 2020 Mar 10.

Department of Ophthalmology, University of Colorado School of Medicine, Aurora, CO, USA.

Introduction: To determine if differences exist between pediatric ophthalmologists and uveitis ophthalmologists in the treatment of pediatric uveitic cataracts and placement of intraocular lenses.

Methods: Uveitis ophthalmologists and pediatric ophthalmologists were surveyed via an online poll regarding their therapeutic management of pediatric uveitic cataract and intraocular lens (IOL) placement.

Results: Sixty-two responses from uveitis ophthalmologists and 47 responses from pediatric ophthalmologists were recorded. Read More

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http://dx.doi.org/10.1007/s40123-020-00245-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196112PMC

Adalimumab effectively controls both anterior and posterior noninfectious uveitis associated with systemic inflammatory diseases: focus on Behçet's syndrome.

Inflammopharmacology 2020 Mar 10. Epub 2020 Mar 10.

Department of Experimental and Clinical Medicine, University of Firenze, 50134, Florence, Italy.

Background: To compare the efficacy of Adalimumab (ADA) in noninfectious anterior uveitis (AU) and posterior segment (PS) involvement, associated with different conditions, with a focus on Behçet's syndrome (BS).

Methods: In this retrospective, multicenter post-hoc study, we evaluated the efficacy of ADA in terms of ocular control and relapses in 96 patients with AU and PS uveitis, either idiopathic (IU) or associated with BS or with other systemic disorders (OSD) (Juvenile Idiopathic Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, Vogt-Koyanagi-Harada, Inflammatory Bowel Disease), followed in three tertiary referral centers.

Results: Ninety-six patients (45 AU; 51 PS uveitis) were included. Read More

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http://dx.doi.org/10.1007/s10787-020-00697-4DOI Listing

Adherence to ophthalmological screening recommendations and course of uveitis in children with juvenile idiopathic arthritis: data from the Inception Cohort of Newly diagnosed patients with JIA (ICON-JIA) study.

Clin Exp Rheumatol 2020 Feb 19. Epub 2020 Feb 19.

Department of Ophthalmology at St. Franziskus Hospital, Münster, and University of Duisburg-Essen, Essen, Germany.

Objectives: As JIA-associated uveitis (JIAU) is asymptomatic in the majority of patients, ophthalmologic screening examinations are recommended, depending on the risk constellation for uveitis development. This study analyses disease characteristics in JIAU depending on adherence with the screening intervals.

Methods: 953 patients were included in the ICON registry. Read More

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February 2020

Low Incidence of Inflammatory Bowel Disease Adverse Events in Adalimumab Clinical Trials Across Nine Different Diseases.

Arthritis Care Res (Hoboken) 2020 Feb 26. Epub 2020 Feb 26.

University of Alabama at Birmingham, Birmingham, AL, United States.

Objective: Adalimumab is approved for treatment of Crohn's disease and ulcerative colitis. Thus, we postulated that exacerbation or new-onset of inflammatory bowel disease (IBD) would be rare events in patients treated with adalimumab for non-IBD indications. This analysis evaluated the incidence of IBD adverse events (AEs) across adalimumab trials. Read More

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http://dx.doi.org/10.1002/acr.24175DOI Listing
February 2020

Quality of life in children suffering from juvenile idiopathic arthritis-associated uveitis.

Rheumatol Int 2020 Feb 22. Epub 2020 Feb 22.

Department of Paediatrics, University Hospital Centre Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia.

Uveitis (JIA-U), the most common extra-articular manifestation in juvenile idiopathic arthritis (JIA), may cause severe impairment of vision in children and affect their quality of life (QoL). Considering the lack of uveitis-related QoL assessment questionnaire, and multidimensional nature of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR), commonly used for monitoring and assessing the health status of children with JIA, we performed a cross-sectional study to investigate the potential of the JAMAR in estimation of QoL in children suffering from JIA-U. The study included 42 children with JIA, 21 of whom had JIA-U. Read More

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http://dx.doi.org/10.1007/s00296-020-04536-1DOI Listing
February 2020

An Unusual Retinal Vessel Modification in Patients Affected by JIA-Uveitis with a Follow-Up Longer Than 16 Years.

Case Rep Ophthalmol Med 2020 28;2020:4720819. Epub 2020 Jan 28.

Department of Ophthalmology, Sapienza University, Umberto I Hospital, Rome, Italy.

Purpose: To report unusual and rare clinical changes of retinal vessel pattern in a series of patients affected by Juvenile Idiopathic Arthritis (JIA) uveitis with a follow-up longer than 16 years.

Methods: A series of three patients with JIA-uveitis followed at the University of Rome "Sapienza" from 1998 to 2014 were reported. The retinal vessels were analyzed with fluorescein angiography using Heidelberg Retinal Angiogram-2 (HRA-2; Heidelberg Engineering GmBH, Dossenheim, Germany) and the Topcon TRC-50LX retinal camera (Topcon Europe, The Netherlands). Read More

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http://dx.doi.org/10.1155/2020/4720819DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7008287PMC
January 2020

Epidemiological and advanced therapeutic approaches to treatment of uveitis in pediatric rheumatic diseases: a systematic review and meta-analysis.

Orphanet J Rare Dis 2020 Feb 4;15(1):41. Epub 2020 Feb 4.

Department of Pediatric Rheumatology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Despite the low prevalence of uveitis in pediatric rheumatic diseases, potential problems as well as high disease burden can complicate its management. In this review, we systematically assessed the epidemiological, etiological, and managerial aspects of uveitis in pediatric rheumatic diseases.

Methods: This current study was conducted in accordance with the established methods and the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). Read More

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http://dx.doi.org/10.1186/s13023-020-1324-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001204PMC
February 2020
3.358 Impact Factor

A CURIOUS CASE OF "DOUBLE CUSHING SYNDROME".

AACE Clin Case Rep 2019 Jan-Feb;5(1):e54-e58. Epub 2019 Jan 30.

Objective: Chronic exogenous steroid therapy can lead to iatrogenic Cushing syndrome (CS). However, concomitant presence of endogenous CS in a patient on exogenous steroids has not been previously reported. We report a case of a 23-year-old who had manifestations of both exogenous as well as endogenous CS. Read More

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http://dx.doi.org/10.4158/ACCR-2018-0197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876982PMC
January 2019

Uveitis in juvenile idiopathic arthritis.

World J Pediatr 2020 Jan 21. Epub 2020 Jan 21.

Department of Rheumatology Immunology and Allergy, Children's Hospital, Zhejiang University School of Medicine, 57# Zhu Gan Road Zhejiang Province, Hangzhou, 310000, China.

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http://dx.doi.org/10.1007/s12519-019-00331-6DOI Listing
January 2020

Biologic Therapies in Polyarticular Juvenile Idiopathic Arthritis. Comparison of Long-Term Safety Data from the German BIKER Registry.

ACR Open Rheumatol 2020 Jan 24;2(1):37-47. Epub 2019 Nov 24.

Asklepios Klinik Sankt Augustin, Sankt Augustin, Germany, and University of Cologne, Cologne, Germany.

Objective: Biologics have an important role in the treatment of juvenile idiopathic arthritis (JIA). Long-term safety data are limited. Direct comparison of different agents regarding occurrence of adverse events (AEs), especially of rare events, requires large quantities of patient years. Read More

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http://dx.doi.org/10.1002/acr2.11091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957918PMC
January 2020

Factors Predictive of Remission of Chronic Anterior Uveitis.

Ophthalmology 2020 Jun 28;127(6):826-834. Epub 2019 Nov 28.

Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts; MCM Eye Unit, MyungSung Christian Medical Center and MyungSung Medical School, Addis Ababa, Ethiopia.

Purpose: To estimate the incidence of medication-free remission of chronic anterior uveitis and identify predictors thereof.

Design: Retrospective cohort study.

Participants: Patients diagnosed with anterior uveitis of longer than 3 months' duration followed up at United States tertiary uveitis care facilities. Read More

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http://dx.doi.org/10.1016/j.ophtha.2019.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246152PMC

JAK inhibitors in refractory juvenile idiopathic arthritis-associated uveitis.

Clin Rheumatol 2020 Mar 2;39(3):847-851. Epub 2020 Jan 2.

Pediatric Rheumatology Unit, ASST G. Pini-CTO, Piazza Cardinale Andrea Ferrari 1, 20122, Milan, Italy.

To present our preliminary experience with JAK inhibitors in treating patients affected by juvenile idiopathic arthritis (JIA) and associated uveitis. Case series. Four consecutive patients with long-term history of juvenile idiopathic arthritis and severe associated uveitis were included in the study. Read More

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http://dx.doi.org/10.1007/s10067-019-04875-wDOI Listing

High-dose intravenous methylprednisolone in juvenile non-infectious uveitis: A retrospective analysis.

Clin Immunol 2020 Feb 18;211:108327. Epub 2019 Dec 18.

Pediatric Rheumatology, Department of Pediatrics, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Germany; Department of Women's & Children's Health, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom; Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust Hospital, Liverpool, United Kingdom. Electronic address:

Non-infectious uveitis is associated with visual impairment and blindness. Non-biologic treatment for non-infectious uveitis is not based on strong evidence. A retrospective chart review was conducted to investigate treatment response to high-dose intravenous methylprednisolone (IVMP) in children with non-infectious uveitis. Read More

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http://dx.doi.org/10.1016/j.clim.2019.108327DOI Listing
February 2020

Juvenile idiopathic arthritis-associated uveitis.

Clin Immunol 2020 Feb 9;211:108322. Epub 2019 Dec 9.

Department of Paediatric Rheumatology, Bristol Royal Hospital for Children, Bristol, UK; Translational Health Sciences, University of Bristol, Bristol, UK. Electronic address:

Juvenile idiopathic arthritis (JIA) is the commonest rheumatic disease in children and JIA-associated uveitis its most frequent extra-articular manifestation. The uveitis is potentially sight-threatening and so carries a considerable risk of morbidity. The commonest form of uveitis seen in JIA is chronic anterior uveitis which is almost always asymptomatic in the initial stages. Read More

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http://dx.doi.org/10.1016/j.clim.2019.108322DOI Listing
February 2020

Treating juvenile idiopathic arthritis (JIA)-related uveitis beyond TNF-α inhibition: a narrative review.

Clin Rheumatol 2020 Feb 10;39(2):327-337. Epub 2019 Dec 10.

Research Center of Systemic Autoinflammatory Diseases, Behçet's Disease and Rheumatology-Ophthalmology Collaborative Uveitis Center, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy.

Chronic anterior uveitis is the most frequent among extra-articular manifestations of juvenile idiopathic arthritis (JIA) and a relevant cause of ocular morbidity in children. Asymmetric arthritis, early onset disease, female sex, and anti-nuclear antibody (ANA) positivity are counted among risk factors for developing this complication. It usually has insidious onset and asymptomatic chronic-relapsing course, but the persistence of low-grade chronic inflammation can lead to irreversible structural ocular damage and to vision-threatening complications. Read More

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http://dx.doi.org/10.1007/s10067-019-04763-3DOI Listing
February 2020

Oral phospholipidic curcumin in juvenile idiopathic arthritis-associated uveitis.

Eur J Ophthalmol 2019 Dec 4:1120672119892804. Epub 2019 Dec 4.

Department of Ophthalmology, IRCCS Ospedale San Raffaele, Vita-Salute San Raffaele University, Milan, Italy.

Purpose: To evaluate the efficacy and the safety of curcumin-phosphatidylcholine complex in children affected by juvenile idiopathic arthritis-associated uveitis as an adjunctive treatment to chronic systemic immunosuppressive therapy.

Methods: In this retrospective, longitudinal study, we treated patients affected by juvenile idiopathic arthritis-associated uveitis with residual low-grade inflammatory activity in the anterior chamber with one tablet of curcumin-phosphatidylcholine complex per day, over a year. Low-grade inflammatory activity was characterized by flare 1+ at slit-lamp examination and 10-50 photon counts per ms) at the FC500 laser flare meter. Read More

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http://dx.doi.org/10.1177/1120672119892804DOI Listing
December 2019

Refractory juvenile psoriatic uveitis without arthritis: a literature review.

J Eur Acad Dermatol Venereol 2020 Apr 23;34(4):e173-e175. Epub 2019 Dec 23.

Department of Dermatology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

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http://dx.doi.org/10.1111/jdv.16127DOI Listing

Overview of Juvenile localized scleroderma and its management.

World J Pediatr 2020 Feb 30;16(1):5-18. Epub 2019 Nov 30.

Department of Rheumatology, Immunology, and Allergy, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.

Background: Juvenile localized scleroderma (JLS) is a rare pediatric disease characterized by inflammation and skin thickening. JLS is associated with deep tissue and extracutaneous involvement that often results in functional impairment and growth disturbances. This article provides an overview of the disease with a focus on active features and treatment. Read More

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http://dx.doi.org/10.1007/s12519-019-00320-9DOI Listing
February 2020

Effectiveness of long-term infliximab use and impact of treatment adherence on disease control in refractory, non-infectious pediatric uveitis.

Pediatr Rheumatol Online J 2019 Nov 29;17(1):79. Epub 2019 Nov 29.

Abrahamson Pediatric Eye Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Background: Refractory non-infectious uveitis is a serious condition that leads to ocular complications and vision loss and requires effective systemic treatment to control disease. The effectiveness of long-term infliximab [IFX] in refractory non-infectious childhood uveitis and the impact of treatment adherence on disease control were evaluated.

Methods: Retrospective, single-center study between December 2002 and April 2016 of 27 children with refractory non-infectious uveitis [17 with juvenile idiopathic arthritis, JIA] treated with long-term IFX [9+ months]. Read More

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http://dx.doi.org/10.1186/s12969-019-0383-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6884783PMC
November 2019

Visual Function And Quality Of Life In A Cohort Of Swedish Children With Juvenile Idiopathic Arthritis.

Clin Ophthalmol 2019 24;13:2081-2091. Epub 2019 Oct 24.

Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

Purpose: To evaluate quality of life (QoL) in children with juvenile idiopathic arthritis (JIA).

Methods: Forty children with a mean age of 7.9 years were included. Read More

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http://dx.doi.org/10.2147/OPTH.S202486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818101PMC
October 2019

The Clinical Characteristics of Pediatric Non-Infectious Uveitis in Two Tertiary Referral Centers in Turkey.

Ocul Immunol Inflamm 2019 Nov 5:1-8. Epub 2019 Nov 5.

Department of Ophthalmology, Ankara University, Ankara, Turkey.

: To report the manifestations, patterns of disease, treatment strategies and outcomes in pediatric patients with noninfectious uveitis.: Demographic information of 76 cases was recorded. Symptoms, anatomic location, laterality, visual acuity (VA), intraocular pressure, associated systemic diseases, therapeutic strategies, side effects, complications were reviewed. Read More

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http://dx.doi.org/10.1080/09273948.2019.1674890DOI Listing
November 2019

Treatment Withdrawal Following Remission in Juvenile Idiopathic Arthritis: A Systematic Review of the Literature.

Paediatr Drugs 2019 Dec;21(6):469-492

Department of Pediatrics, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

Background: Early diagnosis and treatment of juvenile idiopathic arthritis (JIA) with conventional and biologic disease-modifying anti-rheumatic drugs have vastly improved outcomes for children with these diseases. Currently, a large proportion of children with JIA are able to achieve clinical inactive disease and remission. With this success, important questions have arisen about when medications can be stopped and how to balance the risks and benefits of continuing medications versus the potential for flare after stopping. Read More

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http://dx.doi.org/10.1007/s40272-019-00362-6DOI Listing
December 2019

Outcome in juvenile idiopathic arthritis: a population-based study from Sweden.

Arthritis Res Ther 2019 10 28;21(1):218. Epub 2019 Oct 28.

Department of Pediatrics, Clinical Sciences Lund, Lund University, Lund, Sweden.

Background: As the treatment arsenal for children with juvenile idiopathic arthritis (JIA) has expanded during the last decades, follow-up studies are needed on children diagnosed in the era of biological treatment to evaluate if this has improved the outcome. Our aim was to study the epidemiology and outcome of JIA in southern Sweden using a population-based cohort of children with a validated diagnosis of JIA collected over 9 years.

Methods: Potential cases of JIA between 2002 and 2010 were collected after a database search, using the ICD codes M08-M09. Read More

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http://dx.doi.org/10.1186/s13075-019-1994-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6816211PMC
October 2019
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Association of apoptosis genes in PDCD1 but not PDCD1LG2, FAS, and FASLG with pediatric idiopathic uveitis in Han Chinese.

Pediatr Res 2020 Mar 16;87(4):634-638. Epub 2019 Oct 16.

Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair, Zhengzhou, People's Republic of China.

Background: Previous studies have shown that aberrant T lymphocyte apoptosis is involved in the pathogenesis of uveitis. Genetic variants of apoptotic pathway-related factors (including PDCD1, PDCD1LG2, FAS, and FASLG) may affect apoptosis and in turn predict susceptibility to autoimmune disease. This has not yet been studied in pediatric idiopathic uveitis (PIU) and juvenile idiopathic arthritis (JIA)-associated uveitis and was therefore the subject of the study presented here. Read More

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http://dx.doi.org/10.1038/s41390-019-0612-4DOI Listing
March 2020
1 Read
2.314 Impact Factor

Frequency and Identification of Risk Factors of Uveitis in Juvenile Idiopathic Arthritis: A Long-term Follow-up Study in a Cohort of Italian Children.

J Clin Rheumatol 2019 Oct 11. Epub 2019 Oct 11.

From the Pediatric Nephrology and Rheumatology Unit, University Hospital of Messina.

Background: Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease of childhood. The JIA-associated uveitis represents the most common extra-articular manifestation.

Objectives: The main aim of this study was to evaluate frequency and risk factors of uveitis in a pediatric population affected by JIA. Read More

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http://dx.doi.org/10.1097/RHU.0000000000001104DOI Listing
October 2019
1 Read
1.245 Impact Factor

Etiologic Spectrum and Follow-Up Results of Noninfectious Uveitis in Children: A Single Referral Center Experience.

Arch Rheumatol 2019 09 28;34(3):294-300. Epub 2019 Jan 28.

Department of Pediatric Rheumatology, Kanuni Sultan Süleyman Training and Research Hospital, Istanbul, Turkey.

Objectives: This study aims to investigate the etiologic spectrum, demographic features, and long-term follow-up results of children with noninfectious uveitis (NIU).

Patients And Methods: Files of patients with NIU were reviewed between May 2010 and September 2017. The cohort consisted of 54 juvenile uveitis patients (26 males, 28 females; mean age 7. Read More

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http://dx.doi.org/10.5606/ArchRheumatol.2019.7253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768777PMC
September 2019
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Subcutaneous Tocilizumab for Cystoid Macular Edema Secondary to Juvenile Idiopathic Arthritis (JIA)-associated Uveitis: A Case Report.

Ocul Immunol Inflamm 2019 Oct 7:1-3. Epub 2019 Oct 7.

Department of Ophthalmology, Hospital Clinic of Barcelona , Barcelona , Spain.

: To report a case of cystoid macular edema (CME) secondary to juvenile idiopathic arthritis (JIA)-associated uveitis. : 26-year-old female patient presented with CME in both eyes. CME became refractory and TCZ-IV was initiated. Read More

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http://dx.doi.org/10.1080/09273948.2019.1644350DOI Listing
October 2019

Juvenile idiopathic arthritis-associated uveitis: a retrospective analysis from a centre of South Italy.

Int Ophthalmol 2020 Feb 4;40(2):335-342. Epub 2019 Oct 4.

Ophthalmology Unit, Department of Biomedical Sciences, University Hospital of Messina, Messina, Italy.

Purpose: To investigate the clinical and laboratory characteristics of the children affected by juvenile idiopathic arthritis (JIA) who developed uveitis.

Methods: In this retrospective study, we have examined data of 109 patients aged from 3 to 16 years, affected by JIA and followed at Paediatrics Rheumatology Clinic and Ophthalmology Clinic of University Hospital of Messina in the period from 2007 to 2017. The main outcome measures were clinical and laboratory findings related to JIA and ocular involvement. Read More

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http://dx.doi.org/10.1007/s10792-019-01184-8DOI Listing
February 2020
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Same but different? A thematic analysis on adalimumab biosimilar switching among patients with juvenile idiopathic arthritis.

Pediatr Rheumatol Online J 2019 Oct 4;17(1):67. Epub 2019 Oct 4.

Bristol Royal Hospital for Children, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.

Background: Biologic medications have dramatically enhanced the treatment of many chronic paediatric inflammatory conditions. Their high cost is a factor that prohibits their broader use. Cheaper generic versions, or biosimilars, are increasingly being used. Read More

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http://dx.doi.org/10.1186/s12969-019-0366-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6778384PMC
October 2019
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Proposal for a definition for response to treatment, inactive disease and damage for JIA associated uveitis based on the validation of a uveitis related JIA outcome measures from the Multinational Interdisciplinary Working Group for Uveitis in Childhood (MIWGUC).

Pediatr Rheumatol Online J 2019 Oct 1;17(1):66. Epub 2019 Oct 1.

Pediatric Rheumatology Department, Hospital Sant Joan de Déu, Barcelona, Spain.

Background: JIA-associated uveitis (JIAU) is a serious, sight-threatening disease with significant long-term complications and risk of blindness, even with improved contemporary treatments. The MIWGUC was set up in order to propose specific JIAU activity and response items and to validate their applicability for clinical outcome studies.

Methods: The group consists of 8 paediatric rheumatologists and 7 ophthalmologists. Read More

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http://dx.doi.org/10.1186/s12969-019-0345-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774210PMC
October 2019
1 Read
1.622 Impact Factor

Re: Hughes et al.: Cost-effectiveness analysis of adalimumab for the treatment of uveitis associated with juvenile idiopathic arthritis (Ophthalmology. 2019;126:415-424).

Ophthalmology 2019 10;126(10):e77

Save Sight Institute, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia; Sydney Eye Hospital, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1016/j.ophtha.2019.04.039DOI Listing
October 2019
2 Reads

Re: Hughes et al.: Cost-effectiveness analysis of adalimumab for the treatment of uveitis associated with juvenile idiopathic arthritis (Ophthalmology. 2019;126:415-424).

Ophthalmology 2019 10;126(10):e76

Center for Value-Based Medicine, Hilton Head, South Carolina; Wills Eye Hospital, Philadelphia, Pennsylvania; The Eye Research Institute, Philadelphia, Pennsylvania; Thomas Jefferson Medical University, Philadelphia, Pennsylvania; Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia.

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http://dx.doi.org/10.1016/j.ophtha.2019.04.040DOI Listing
October 2019
2 Reads