1,055 results match your criteria Uveitis Intermediate


Pattern and Outcome of Uveitis in a Tertiary Military Hospital in Thailand.

Ocul Immunol Inflamm 2019 Apr 22:1-9. Epub 2019 Apr 22.

a Ocular inflammation and infection division, Department of Ophthalmology, Phramongkutklao hospital , Phramongkutklao college of Medicine , Bangkok , Thailand.

Background: Causes of uveitis vary upon the epidemiologic, racial, and geographical variations.

Objective: The objective of the study is to analyze pattern and outcome of uveitis in Phramongkutklao Hospital.

Methods: This is a retrospective study. Read More

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http://dx.doi.org/10.1080/09273948.2019.1589527DOI Listing

[Ocular Syphilis May Lead to Persistent Visual Dysfunction].

Klin Monbl Augenheilkd 2019 Apr 18;236(4):516-522. Epub 2019 Apr 18.

Augenklinik, UniversitätsSpital Zürich, Universität Zürich, Schweiz.

Purpose: The spectrum of intraocular and systemic findings in patients with ocular syphilis is described. Persistent visual dysfunction and structural abnormality, in spite of targeted antibiotic therapy, were identified and analysed.

Methods: Patients with ocular syphilis who were treated at University Hospital Zurich (USZ) between 2010 and 2018 were included in this study. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0854-3421
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http://dx.doi.org/10.1055/a-0854-3421DOI Listing
April 2019
1 Read

Epidemiology of uveitis in urban Australia.

Clin Exp Ophthalmol 2019 Apr 11. Epub 2019 Apr 11.

Centre for Eye Research Australia, Victoria, Australia.

Importance: few prior studies have described the epidemiology of uveitis in the Australian population.

Background: to report the incidence and period prevalence of active uveitis in Melbourne and detail their subtypes and etiologies.

Design: cross-sectional study using retrospective medical record review in a tertiary hospital. Read More

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http://dx.doi.org/10.1111/ceo.13517DOI Listing

Juvenile idiopathic arthritis-related uveitis mimicking endophthalmitis.

J AAPOS 2019 Apr 5. Epub 2019 Apr 5.

Vitreo-retina, Trauma and Uvea Services; Dr. Rajendra Prasad Center for Ophthalmic Sciences; All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.

Juvenile idiopathic arthritis (JIA) is a group of disorders occurring in children with arthritis of more than 6 weeks' duration. JIA may have varied systemic and ocular presentations, which can pose a diagnostic challenge. Chronic uveitis with insidious onset is the most common type of ocular presentation. Read More

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http://dx.doi.org/10.1016/j.jaapos.2019.03.001DOI Listing

Remission Of Non-Infectious Anterior Scleritis: Incidence And Predictive Factors.

Am J Ophthalmol 2019 Apr 2. Epub 2019 Apr 2.

Department of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.

Purpose: To assess how often non-infectious anterior scleritis remits and identify predictive factors.

Methods: Our retrospective cohort study at four ocular inflammation subspecialty centers collected data for each affected eye/patient at every visit from center inception (1978, 1978, 1984, 2005) until 2010. Remission was defined as inactivity of disease off all suppressive medications at all visits spanning at least three consecutive months or at all visits up to the last visit (to avoid censoring patients stopping follow-up after remission). Read More

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http://dx.doi.org/10.1016/j.ajo.2019.03.024DOI Listing
April 2019
1 Read

Bartonella henselae- and quintana-associated uveitis: a case series and approach of a potentially severe disease with a broad spectrum of ocular manifestations.

Int Ophthalmol 2019 Mar 9. Epub 2019 Mar 9.

Department of Ophthalmology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Stavros Niarchos Avenue, 45110, Ioannina, Greece.

Purpose: To evaluate the clinical manifestations of intraocular inflammation associated with Bartonella infection and describe the assessment and management of patients with cat-scratch disease (CSD).

Methods: This is a retrospective review of the clinical records of patients diagnosed with Bartonella henselae and Bartonella quintana intraocular inflammation from 2011 to 2018 in the Department of Ocular Inflammations and Infections of the University Eye Clinic of Ioannina (Greece). An analysis of the current literature concerning Bartonella-related intraocular infections was also carried out. Read More

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http://link.springer.com/10.1007/s10792-019-01096-7
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http://dx.doi.org/10.1007/s10792-019-01096-7DOI Listing
March 2019
18 Reads

Biologics for the treatment of noninfectious uveitis: current concepts and emerging therapeutics.

Authors:
Akshay S Thomas

Curr Opin Ophthalmol 2019 May;30(3):138-150

Tennessee Retina, Nashville, USA.

Purpose Of Review: There is mounting evidence supporting the use of biologic therapeutics for the management of noninfectious uveitis (NIU). This review highlights: biologics with documented efficacy in NIU; agents with ongoing evaluation for efficacy in uveitis; and therapeutics for which investigation for efficacy in NIU is warranted.

Recent Findings: The tumor necrosis factor-alpha (TNF-α) inhibitor adalimumab has recently gained approval by the Food and Drug Administration for the treatment of noninfectious intermediate, posterior, and panuveitis. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000562DOI Listing
May 2019
12 Reads

Epidemiology of Macular Edema in Uveitis.

Ocul Immunol Inflamm 2019 Mar 1:1-12. Epub 2019 Mar 1.

d IRCCS - Fondazione Bietti , Rome , Italy.

Purpose: To describe the epidemiology of macular edema (ME) in patients with uveitis.

Methods: Review of articles listed on PubMed pertaining to uveitic ME.

Results: Reported rates of uveitic ME ranging from 20% to 70%, depending on the ancillary tests used (fundus examination, fluorescein angiography, optical coherence tomography). Read More

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http://dx.doi.org/10.1080/09273948.2019.1576910DOI Listing
March 2019
2 Reads

Uveitis in Patients Treated with CTLA-4 and PD-1 Checkpoint Blockade Inhibition.

Ocul Immunol Inflamm 2019 Mar 1:1-11. Epub 2019 Mar 1.

a Department of Ophthalmology, Jules Stein Eye Institute , David Geffen School of Medicine at the University of California Los Angeles , Los Angeles , CA , USA.

Purpose: To investigate the link between treatment with CTLA-4 and PD-1 checkpoint blockade inhibitors and the development of noninfectious uveitis.

Methods: A survey was distributed to uveitis specialists to identify patients who developed uveitis while receiving either PD-1 inhibitors pembrolizumab and nivolumab; PD-L1 inhibitors atezolizumab, avelumab, and durvalumab; or the CTLA-4 inhibitor ipilimumab.

Results: Fifteen patients from seven institutions were identified. Read More

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https://www.tandfonline.com/doi/full/10.1080/09273948.2019.1
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http://dx.doi.org/10.1080/09273948.2019.1577978DOI Listing
March 2019
9 Reads
1.440 Impact Factor

Visual and Clinical Outcome of Macular Edema Complicating Pediatric Noninfectious Uveitis.

Am J Ophthalmol 2019 Feb 14. Epub 2019 Feb 14.

Department of Ophthalmology , Rabin Medical Center, Petach Tikva, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Purpose: To investigate the clinical course and visual outcome of macular edema (ME) in pediatric patients with chronic noninfectious uveitis.

Design: Retrospective case series.

Methods: The databases of the uveitis clinics of four tertiary medical centers in Israel and the UK were searched for all children treated for uveitic ME in 2005-2015. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.011DOI Listing
February 2019

Dexamethasone implant for non-infectious uveitis: is it cost-effective?

Br J Ophthalmol 2019 Feb 11. Epub 2019 Feb 11.

Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.

Background: Uveitis is inflammation inside the eye. The objective of this study is to assess the cost-effectiveness of a dexamethasone implant plus current practice (immunosuppressants and systemic corticosteroids) compared with current practice alone, in patients with non-infectious intermediate, posterior or pan-uveitis and to identify areas for future research.

Methods: A Markov model was built to estimate the costs and benefits of dexamethasone. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3127
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http://dx.doi.org/10.1136/bjophthalmol-2018-312765DOI Listing
February 2019
8 Reads
2.976 Impact Factor

Swept-source optical coherence tomography angiography reveals vascular changes in intermediate uveitis.

Acta Ophthalmol 2019 Feb 6. Epub 2019 Feb 6.

Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Purpose: To evaluate retinal and choroidal vascular changes in patients with intermediate uveitis with/without concomitant retinal vasculitis using wide field swept-source optical coherence tomography angiography (OCTA).

Methods: In this study consecutive patients with intermediate uveitis ± vasculitis and healthy age-matched controls were evaluated using central 3 × 3 mm OCTA scans and montage scans. Differences among the groups as well as the association between central changes assessed by 3 × 3 scans and wide field OCTA were evaluated. Read More

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http://dx.doi.org/10.1111/aos.14024DOI Listing
February 2019
1 Read

Adalimumab for non-infectious uveitis: is it cost-effective?

Br J Ophthalmol 2019 Feb 6. Epub 2019 Feb 6.

Department of Opthalmology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Background/aims: Uveitis is inflammation inside the eye. Our objective was to assess the cost-effectiveness of adalimumab compared with current practice (immunosuppressants and systemic corticosteroids) in patients with non-infectious intermediate, posterior or panuveitis and to identify areas for future research.

Methods: A Markov model was built to estimate costs and benefits of the interventions. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3127
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http://dx.doi.org/10.1136/bjophthalmol-2018-312756DOI Listing
February 2019
10 Reads

In Situ Gel of Triamcinolone Acetonide-Loaded Solid Lipid Nanoparticles for Improved Topical Ocular Delivery: Tear Kinetics and Ocular Disposition Studies.

Nanomaterials (Basel) 2018 Dec 27;9(1). Epub 2018 Dec 27.

Department of Pharmaceutics and Drug Delivery, School of Pharmacy, The University of Mississippi, MS 38677, USA.

Triamcinolone acetonide (TA), an intermediate acting corticosteroid, is used in the treatment of posterior ocular diseases, such as inflammation, posterior uveitis, and diabetic macular edema. The objective of this investigation was to prepare TA-loaded solid lipid nanoparticles (TA-SLNs) and in situ gel (TA-SLN-IG) formulations for delivery into the deeper ocular tissues through the topical route. TA-SLNs were prepared by hot homogenization and ultrasonication method using glyceryl monostearate and Compritol 888ATO as solid lipids and Tween80 and Pluronic F-68 as surfactants. Read More

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http://www.mdpi.com/2079-4991/9/1/33
Publisher Site
http://dx.doi.org/10.3390/nano9010033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358857PMC
December 2018
11 Reads

Association of Ocular Inflammation and Rubella Virus Persistence.

JAMA Ophthalmol 2018 Dec 27. Epub 2018 Dec 27.

Francis I. Proctor Foundation, University of California, San Francisco.

Importance: Metagenomic deep sequencing (MDS) demonstrates that persistent and active rubella virus (RV) infection is associated with Fuchs heterochromic iridocyclitis (FHI).

Objective: To assess the utility of MDS in identifying RV infection in patients with uveitis.

Design, Setting, And Participants: This case series assessed 6 patients diagnosed by MDS with RV-associated uveitis at a tertiary uveitis referral center in the United States. Read More

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http://dx.doi.org/10.1001/jamaophthalmol.2018.6185DOI Listing
December 2018
2 Reads

Epidemiological profile of non-infectious uveitis from the rheumatologist's perspective: a survey from two tertiary referral centres in Italy.

Clin Exp Rheumatol 2018 Nov-Dec;36(6 Suppl 115):68-73. Epub 2018 Dec 12.

Research Centre of Systemic Autoinflammatory Diseases and Behçet's Disease and Rheumatology-Ophthalmology Collaborative Uveitis Centre, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Italy.

Objectives: To describe the epidemiology of non-infectious uveitis (NIU) in two tertiary referral rheumatology units in Central and Southern Italy.

Methods: Two hundred and seventy-eight consecutive NIU patients (417 eyes) evaluated between January 2016 and January 2017 were enrolled. Collected data were analysed in accordance with the primary anatomic site of inflammation, clinical course, and laterality. Read More

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March 2019
10 Reads

Tofacitinib for refractory uveitis and scleritis.

Am J Ophthalmol Case Rep 2019 Mar 4;13:53-55. Epub 2018 Dec 4.

Department of Medicine, Saint Louis, MO, 63110, USA.

Purpose: To report the successful use of tofacitinib in the treatment of refractory uveitis and scleritis.

Observations: Two patients, one with scleritis and another with anterior and intermediate uveitis, presented with refractory disease after failure of multiple steroid-sparing therapies. Treatment with tofacitinib led to durable resolution of uveitis and scleritis. Read More

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http://dx.doi.org/10.1016/j.ajoc.2018.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288302PMC
March 2019
1 Read

Acute hypertensive uveitis as the first presentation of multiple sclerosis.

Indian J Ophthalmol 2019 Jan;67(1):163-164

Department of Ophthalmology, The Queen Elizabeth Hospital; Department of Ophthalmology, The Royal Adelaide Hospital; The South Australian Institute of Ophthalmology, Adelaide, South Australia, Australia.

Ophthalmic manifestations of multiple sclerosis are frequent including acute optic neuritis, ocular motor disturbances and intermediate uveitis. We report an unusual case of multiple sclerosis presenting as acute hypertensive uveitis. A 56-year-old man was referred by his family doctor with a 2-week history of right eye pain and decreased vision. Read More

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http://dx.doi.org/10.4103/ijo.IJO_345_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324108PMC
January 2019
3 Reads

Relationship between age at onset and clinical characteristics of Behçet's disease.

Acta Dermatovenerol Alp Pannonica Adriat 2018 Dec;27(4):175-177

Department of Internal Medicine, Hospital University Tidjani Damerdji, Tlemcen, Algeria.

Introduction: This study compares the clinical characteristics and treatment modalities of Behçet's disease patients by age of onset at the Dr. Tidjani Damerdji University Hospital Center in Tlemcen, Algeria.

Methods: Data from patients treated for Behçet's disease between January 1990 and December 2016 were analyzed retrospectively. Read More

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December 2018

Evaluation of vascular changes in intermediate uveitis and retinal vasculitis using swept-source wide-field optical coherence tomography angiography.

Br J Ophthalmol 2018 Dec 11. Epub 2018 Dec 11.

Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland

Purpose: To evaluate vascular changes in patients with intermediate uveitis with or without retinal vasculitis using swept-source wide-field optical coherence tomography angiography (OCTA).

Methods: This is a prospective cross-sectional study. Consecutive patients with intermediate uveitis were evaluated using wide-field OCTA. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313078DOI Listing
December 2018
1 Read

A Retrospective Observational Study of Uveitis in a Single Center in Poland with a Review of Findings in Europe.

Med Sci Monit 2018 Dec 3;24:8734-8749. Epub 2018 Dec 3.

Department of Ophthalmology, Medical University of Warsaw, Warsaw, Poland.

BACKGROUND This study aimed to review the causes, presentation, and clinicopathological associations of uveitis in a single department of ophthalmology in Poland, and to compare the findings with previously published studies from other European countries. MATERIAL AND METHODS Review of local patient records between 2005-2015 identified patients diagnosed with uveitis. Data obtained included age, gender, imaging findings, and laboratory diagnostic findings. Read More

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https://www.medscimonit.com/abstract/index/idArt/910749
Publisher Site
http://dx.doi.org/10.12659/MSM.910749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289025PMC
December 2018
15 Reads

Uveitis and spondyloarthropathies.

Best Pract Res Clin Rheumatol 2017 12 25;31(6):846-862. Epub 2018 Oct 25.

Oxford Eye Hospital, John Radcliffe Hospital, Headley Way, Oxford, United Kingdom. Electronic address:

Uveitis is a frequently occurring extra-articular manifestation of spondyloarthropathies (SpAs), ankylosing spondylitis (AS), reactive arthritis (ReA), psoriatic arthritis (PsA) and inflammatory bowel disease (IBD), occurring in both adults and children with SpA. Uveitis occurs with varying frequency according to the SpA subtype (33% in AS, 6-9% in PsA, 25% in ReA, 13% in undifferentiated SpA and 2-5% in IBD), the presence of HLA-B27 and with increasing duration of disease. The majority of cases of uveitis in SpA are attributed to acute anterior uveitis but a minority of uveitis cases occur in the posterior segment of the eye. Read More

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http://dx.doi.org/10.1016/j.berh.2018.08.002DOI Listing
December 2017
3 Reads
2.603 Impact Factor

Emerging infectious uveitis: Chikungunya, dengue, Zika and Ebola: A review.

Clin Exp Ophthalmol 2019 Apr 2;47(3):372-380. Epub 2019 Jan 2.

Eye & Vision Health, Flinders University College of Medicine and Public Health, Adelaide, Australia.

Recently recognized forms of uveitis include intraocular inflammations that occur during or following one of several emerging infectious diseases: chikungunya fever, dengue, Zika virus disease and Ebola virus disease. Anterior, intermediate, posterior and pan-uveitis have been described in individuals infected with chikungunya virus. Persons who contract dengue or Zika viruses also may develop different types of uveitis in the course of the infection: maculopathy is a common manifestation of dengue eye disease, and Zika eye disease may cause hypertensive anterior uveitis or mimic a white dot syndrome. Read More

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http://doi.wiley.com/10.1111/ceo.13450
Publisher Site
http://dx.doi.org/10.1111/ceo.13450DOI Listing
April 2019
22 Reads

New data in causes of autoinflammatory diseases.

Joint Bone Spine 2018 Nov 22. Epub 2018 Nov 22.

Centre national de référence des maladies auto-inflammatoires et de l'amylose inflammatoire (CEREMAIA), 94270 Le Kremlin-Bicêtre, France; Cellules souches, plasticité cellulaire, médecine régénératrice et immunothérapies, Inserm, Université de Montpellier, 34090 Montpellier, France; Département de génétique médicale, maladies rares et médecine personnalisée, CHU de Montpellier, 34295 Montpellier, France.

The spectrum of factors known to mediate autoinflammation has broadened recently to include not only interleukin-1 (IL-1) and interferon, but also abnormalities that impair NF-κB pathway negative regulation. The NF-κB pathway is activated upon contact of a ligand with tumor necrosis factor receptor 1 (TNFR1) and plays a pivotal role in triggering the inflammatory process by producing major cytokines such as IL-1, IL-6, and TNF. Negative regulation of the NF-κB pathway, which is essential to stop the inflammatory process, depends on the level of ubiquitination of the proteins associated with TNFR1 and of other intermediate compounds. Read More

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http://dx.doi.org/10.1016/j.jbspin.2018.11.003DOI Listing
November 2018
29 Reads

New insight into the diagnostic cut-off value of serum anti-Toxocara IgG for ocular toxocariasis in uveitis patients.

J Helminthol 2018 Nov 20:1-6. Epub 2018 Nov 20.

Department of Ophthalmology,Faculty of Medicine,Zagazig University,Egypt.

Uveitis is one of the commonest causes of vision loss worldwide and its exact etiology is still not clarified in most patients. The current study is a trial to assess the efficacy of serum anti-Toxocara immunoglobulin G (IgG) by enzyme-linked immunosorbent assay (ELISA) as a diagnostic tool for ocular toxocariasis (OT) and to detect OT prevalence and the associated ocular manifestations in sera of patients with uveitis. One hundred and twelve patients (62 females and 50 males) with uveitis were diagnosed by ophthalmologists, radiologists and rheumatologists according to ocular manifestations, laboratory and radiological investigations. Read More

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http://dx.doi.org/10.1017/S0022149X18000895DOI Listing
November 2018
2 Reads

High-Dimensional Profiling Reveals Heterogeneity of the Th17 Subset and Its Association With Systemic Immunomodulatory Treatment in Non-infectious Uveitis.

Front Immunol 2018 31;9:2519. Epub 2018 Oct 31.

Ophthalmo-Immunology Unit, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.

Non-infectious uveitis (NIU) is a severe intra ocular inflammation, which frequently requires prompt systemic immunosuppressive therapy (IMT) to halt the development of vision-threatening complications. IMT is considered when NIU cannot be treated with corticosteroids alone, which is unpredictable in advance. Previous studies have linked blood cell subsets to glucocorticoid sensitivity, which suggests that the composition of blood leukocytes may early identify patients that will require IMT. Read More

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http://dx.doi.org/10.3389/fimmu.2018.02519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220365PMC
October 2018
3 Reads

Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) - Report 2: Pattern of Uveitis Investigations in Singapore.

Ocul Immunol Inflamm 2018 Oct 18:1-8. Epub 2018 Oct 18.

a Yong Loo Lin School of Medicine , National University of Singapore , Singapore , Singapore.

Purpose: To analyze the pattern of laboratory investigations of uveitis at a tertiary referral eye care center in Singapore.

Methods: Retrospective analysis of 2040 uveitis cases from the Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) database over a 12-year period (2004 - 2015).

Results: Patients with retinal vasculitis (RV) had the most tests utilized per patient (6. Read More

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http://dx.doi.org/10.1080/09273948.2018.1535080DOI Listing
October 2018
3 Reads
1.440 Impact Factor

Descemet Membrane Endothelial Keratoplasty (DMEK) Graft Dislocation Into the Vitreous Cavity.

Cornea 2019 Feb;38(2):173-176

Vitreo-Retinal Service, Moorfields Eye Hospital, London, United Kingdom.

Purpose: To present our experience of Descemet stripping endothelial keratoplasty (DMEK) graft luxation into the vitreous cavity in 2 cases.

Methods: DMEK was performed in 2 patients with aphakic bullous keratopathy. The indications for keratoplasty were endothelial failure caused by chronic intermediate uveitis and glaucoma in 1 case and decompensated previous penetrating keratoplasty in the other. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001788DOI Listing
February 2019
5 Reads

Demographic and Clinical Features of Pediatric Uveitis in Israel.

Ocul Immunol Inflamm 2018 Oct 17:1-11. Epub 2018 Oct 17.

b Department of Ophthalmology, Hadassah Medical Center , The Hebrew University Hadassah Medical School , Jerusalem , Israel.

Purpose: To report the epidemiology, etiology, ocular characteristics, treatment and visual outcome of pediatric uveitis in Israel.

Methods: Retrospective study from two tertiary uveitis centers.

Results: Included were 107 patients (182 eyes), 55% females. Read More

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https://www.tandfonline.com/doi/full/10.1080/09273948.2018.1
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http://dx.doi.org/10.1080/09273948.2018.1535079DOI Listing
October 2018
14 Reads

Efficacy and Safety of Sarilumab for the Treatment of Posterior Segment Noninfectious Uveitis (SARIL-NIU):: The Phase 2 SATURN Study.

Ophthalmology 2019 Mar 11;126(3):428-437. Epub 2018 Oct 11.

Byers Eye Institute, Stanford University, Palo Alto, California. Electronic address:

Purpose: To assess efficacy and safety of sarilumab, a human anti-interleukin-6 receptor antibody, for treatment of posterior segment noninfectious uveitis (NIU).

Design: Randomized, double-masked, placebo-controlled, phase 2 study.

Participants: Fifty-eight patients (eyes) with noninfectious intermediate, posterior, or panuveitis. Read More

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http://dx.doi.org/10.1016/j.ophtha.2018.09.044DOI Listing
March 2019
5 Reads

An unusual case report of primary vitreoretinal lymphoma.

BMC Ophthalmol 2018 Sep 14;18(Suppl 1):223. Epub 2018 Sep 14.

Centre for Ophthalmology and Vision Sciences, Faculty of Medical and Human Sciences, Medicine and Health, University of Manchester, Manchester, UK.

Background: Primary vitreoretinal lymphoma (PVRL) is a rare ocular condition and its diagnosis remains a challenge. The clinical presentation is variable and it can masquerade as chronic intermediate or posterior uveitis. We report an unusual case of primary central nervous system lymphoma (PCNSL) presenting as migrating retinal lesions with unique shapes. Read More

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http://dx.doi.org/10.1186/s12886-018-0860-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156902PMC
September 2018
3 Reads

An experimental study to evaluate safety/toxicity of intravitreal natalizumab.

Indian J Ophthalmol 2018 Oct;66(10):1441-1445

Department of Ocular Pharmacology and Pharmacy, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, New Delhi, India.

Purpose: The purpose of this prospective experimental study was to evaluate the safety/toxicity of α4β1 integrin blockade in rabbit retina using its monoclonal antibody (Natalizumab).

Methods: Twelve New Zealand albino rabbits were divided into three groups (n = 4). Unilateral intravitreal injections of three different concentrations of natalizumab were performed in every rabbit of each group (Group A: 0. Read More

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http://dx.doi.org/10.4103/ijo.IJO_425_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173036PMC
October 2018
13 Reads

Oral corticosteroid exposure and increased risk of related complications in patients with noninfectious intermediate, posterior, or panuveitis: Real-world data analysis.

Ophthalmic Epidemiol 2019 02 10;26(1):27-46. Epub 2018 Sep 10.

a Real-World Evidence , Pharmerit International , Bethesda , MD , USA.

Purpose: This study causally examined the dose-response relationship between oral corticosteroids (OCS) exposure and long-term complications among noninfectious uveitis adult patients in the United States.

Methods: The study design was longitudinal, retrospective cohort using Truven Health MarketScan claims database years 2000-2015. The index date was the first day after diagnosis on which OCS≥ 5 mg prednisone equivalent was administered. Read More

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https://www.tandfonline.com/doi/full/10.1080/09286586.2018.1
Publisher Site
http://dx.doi.org/10.1080/09286586.2018.1513042DOI Listing
February 2019
6 Reads

An investigation on optic nerve head involvement in Fuchs uveitis syndrome using optical coherence tomography and fluorescein angiography.

Graefes Arch Clin Exp Ophthalmol 2018 Dec 3;256(12):2421-2427. Epub 2018 Sep 3.

Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Qazvin Square, Tehran, 13352, Iran.

Purpose: To investigate optic nerve head involvement in patients with Fuchs uveitis syndrome (FUS).

Methods: Optic nerve head of 43 FUS eyes without clinical optic disc edema and 37 unaffected fellow eyes were evaluated using optical coherence tomography (OCT) of peripapillary retina and retinal nerve fiber layer (RNFL) and fundus fluorescein angiography.

Results: Seventy-one percent of FUS eyes showed optic nerve head hyperfluorescence. Read More

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http://link.springer.com/10.1007/s00417-018-4125-3
Publisher Site
http://dx.doi.org/10.1007/s00417-018-4125-3DOI Listing
December 2018
12 Reads

Anterior and Intermediate Uveitis Following Yellow Fever Vaccination with Fractional Dose: Case Reports.

Ocul Immunol Inflamm 2018 Aug 28:1-3. Epub 2018 Aug 28.

a Ophthalmology Department , Universidade Federal do Rio de Janeiro , Rio de Janeiro , Brazil.

Purpose: To describe two cases of anterior and intermediate uveitis following yellow fever vaccination with fractional dose.

Methods: Case report.

Results: Case 1: A 35 year-old healthy woman presented with unilateral anterior uveitis 10 days after the yellow fever vaccination. Read More

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http://dx.doi.org/10.1080/09273948.2018.1510529DOI Listing
August 2018
10 Reads

Clinical Manifestations and Ophthalmic Outcomes of Ocular Syphilis at a Time of Re-Emergence of the Systemic Infection.

Sci Rep 2018 Aug 13;8(1):12071. Epub 2018 Aug 13.

Flinders University College of Medicine and Public Health, Adelaide, Australia.

Recent reports from different world regions suggest ocular syphilis is re-emerging, in parallel with an increasing incidence of the systemic infection globally. We conducted a large observational study of 127 persons consecutively treated for ocular syphilis at public medical centers in Brazil over a 2.5-year period ending July 2015. Read More

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http://dx.doi.org/10.1038/s41598-018-30559-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089995PMC
August 2018
11 Reads

Comparative efficacy between adalimumab and infliximab in the treatment of non-infectious intermediate uveitis, posterior uveitis, and panuveitis: a retrospective observational study of 107 patients.

Clin Rheumatol 2019 Feb 11;38(2):407-415. Epub 2018 Aug 11.

Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease and Rheumatology-Ophthalmology Collaborative Uveitis Center, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Policlinico "Le Scotte", viale Bracci 1, 53100, Siena, Italy.

To compare the efficacy of adalimumab (ADA) and infliximab (IFX) in patients with non-infectious intermediate uveitis, posterior uveitis, and panuveitis. Demographic, clinical, instrumental, and therapeutic data from patients enrolled were collected at the start of treatment, at 12-month follow-up, and at the last follow-up assessment. One hundred seven patients (46 females, 187 eyes) were enrolled, 66 (61. Read More

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http://dx.doi.org/10.1007/s10067-018-4228-6DOI Listing
February 2019
9 Reads

Intravitreal Sirolimus for the Treatment of Noninfectious Uveitis: Evolution through Preclinical and Clinical Studies.

Ophthalmology 2018 Dec 27;125(12):1984-1993. Epub 2018 Jul 27.

Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California.

In recent decades, the treatment paradigm for noninfectious intermediate uveitis, posterior uveitis, and panuveitis, a group of intraocular inflammatory diseases, has included systemic and local (periocular or intraocular) corticosteroids, biologics, and other steroid-sparing immunomodulatory therapy agents. Recently, an intravitreal formulation of sirolimus, an immunosuppressant that inhibits the mammalian target of rapamycin, a key regulator of cell growth in the immune system, was developed. On the basis of this mechanism and the local method of delivery, it was hypothesized that intravitreal sirolimus can improve ocular inflammation in patients with noninfectious intermediate uveitis, posterior uveitis, and panuveitis, with minimal systemic exposure and systemic adverse events (AEs). Read More

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http://dx.doi.org/10.1016/j.ophtha.2018.06.015DOI Listing
December 2018
8 Reads

Fuchs' Uveitis in Iranian Patients: A Review of 89 Eyes.

Ocul Immunol Inflamm 2018 Jul 30:1-9. Epub 2018 Jul 30.

a Farabi Eye Research Center , Tehran University of Medical Sciences , Tehran , Iran.

Purpose: To describe clinical and imaging features of Fuchs' Uveitis (FU) and investigate the rate of misdiagnosis in Iranian patients.

Methods: Records of 82 FU patients (89 eyes) were reviewed retrospectively.

Results: Remarkable findings included iris heterochromia in 14 (17. Read More

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http://dx.doi.org/10.1080/09273948.2018.1500612DOI Listing

Serum Angiotensin-Converting Enzyme Has a High Negative Predictive Value in the Investigation for Systemic Sarcoidosis.

Am J Ophthalmol 2018 Oct 24;194:82-87. Epub 2018 Jul 24.

Univerisity College London and Moorfields Eye Hospital, London, United Kingdom.

Purpose: To examine whether measurement of serum angiotensin-converting enzyme (ACE) is useful in diagnosing sarcoidosis in undifferentiated uveitis.

Design: Evaluation of a diagnostic test.

Methods: Data collection was performed from 1035 consecutive subjects presenting with uveitis to Moorfields Eye Hospital undergoing measurement of serum ACE as part of baseline investigations for underlying systemic disease. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394183039
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http://dx.doi.org/10.1016/j.ajo.2018.07.010DOI Listing
October 2018
5 Reads

Optical Coherence Tomography Angiography in Intermediate Uveitis.

Am J Ophthalmol 2018 Oct 17;194:35-45. Epub 2018 Jul 17.

Department of Ophthalmology, University of Bonn, Bonn, Germany. Electronic address:

Purpose: To investigate the involvement of the retinal and choriocapillaris microvasculature in intermediate uveitis on optical coherence tomography angiography (OCT-A).

Design: Case-control study.

Methods: Patients and age-matched controls were imaged with swept-source OCT-A. Read More

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http://dx.doi.org/10.1016/j.ajo.2018.06.023DOI Listing
October 2018
1 Read

Patterns of uveitis in patients with proven systemic (pulmonary and extrapulmonary) tuberculosis.

Int Ophthalmol 2018 Jul 18. Epub 2018 Jul 18.

Retina and Uvea Services, Dr R P Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.

Purpose: To report patterns of uveitis in patients with systemic tuberculosis.

Methods: Records of patients presenting at uvea clinic of a tertiary eye care centre were evaluated retrospectively, and 47 cases with proven systemic tuberculosis were analyzed for patterns of uveitis. Tuberculosis had been proven with a combination of radio imaging and detection of acid fast bacilli in body fluids. Read More

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http://dx.doi.org/10.1007/s10792-018-0989-9DOI Listing
July 2018
26 Reads

Adalimumab in Active and Inactive, Non-Infectious Uveitis: Global Results from the VISUAL I and VISUAL II Trials.

Ocul Immunol Inflamm 2018 Jul 17:1-11. Epub 2018 Jul 17.

c Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine , Hokkaido University , Sapporo , Japan.

Purpose: Report global adalimumab safety and efficacy outcomes in patients with non-infectious uveitis.

Methods: Adults with non-infectious intermediate, posterior, or panuveitis were randomized 1:1 to receive placebo or adalimumab in the VISUAL I (active uveitis) or VISUAL II (inactive uveitis) trials. Integrated global and Japan substudy results are reported. Read More

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http://dx.doi.org/10.1080/09273948.2018.1491605DOI Listing
July 2018
10 Reads

Bilateral cystoid macular edema misdiagnosed as pars planitis in a patient on sertraline therapy.

Am J Ophthalmol Case Rep 2018 Sep 28;11:135-138. Epub 2018 Jun 28.

Advanced Eye Center, Department of Ophthalmology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Purpose: To describe the presentation, clinical course and management of a patient with bilateral maculopathy associated with sertraline.

Observations: We report a rare case of bilateral cystoid macular edema and subretinal fluid in a 78-year-old Asian Indian female who was on chronic sertraline therapy. The patient was initially misdiagnosed as intermediate uveitis and started on oral corticosteroids. Read More

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http://dx.doi.org/10.1016/j.ajoc.2018.06.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031226PMC
September 2018
5 Reads

A Cross-Sectional Observational Study of Nailfold Capillary Morphology in Uveitis.

Curr Eye Res 2018 Nov 31;43(11):1342-1350. Epub 2018 Jul 31.

a Department of Ophthalmology , Peking University First Hospital , Beijing , China.

Purpose: We performed nailfold capillary microscopy to explore microvasculature abnormalities in uveitis overall and uveitis stratified in various ways.

Methods: This was a cross-sectional, case-control, observational study. One hundred and seven uveitis patients and 130 control subjects were included. Read More

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http://dx.doi.org/10.1080/02713683.2018.1496265DOI Listing
November 2018
5 Reads
1.660 Impact Factor

Clinical features of paediatric uveitis at a tertiary referral centre in São Paulo, SP, Brazil.

Br J Ophthalmol 2018 Jun 15. Epub 2018 Jun 15.

Department of Ophthalmology, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.

Aims: To analyse the clinical features, systemic associations, treatment and visual outcomes of uveitis in children from a referral centre in São Paulo, Brazil.

Methods: Clinical records of patients under 16 years old who attended the Uveitis Service, Hospital das Clinicas, Faculdadede Medicina, Universidade de São PauloFMUSP, between April and September 2017, were reviewed retrospectively. Patients with incomplete medical records, previous ocular trauma, or less than six6 months of follow-up were excluded. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3123
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http://dx.doi.org/10.1136/bjophthalmol-2018-312313DOI Listing
June 2018
11 Reads

Clinical Remission of Sight-Threatening Non-Infectious Uveitis Is Characterized by an Upregulation of Peripheral T-Regulatory Cell Polarized Towards T-bet and TIGIT.

Front Immunol 2018 3;9:907. Epub 2018 May 3.

Ocular Immunology, Institute of Ophthalmology, University College London (UCL), London, United Kingdom.

Background: Non-infectious uveitis can cause chronic relapsing and remitting ocular inflammation, which may require high dose systemic immunosuppression to prevent severe sight loss. It has been classically described as an autoimmune disease, mediated by pro-inflammatory Th1 and Th17 T-cell subsets. Studies suggest that natural immunosuppressive CD4CD25FoxP3 T-regulatory cells (Tregs) are involved in resolution of inflammation and may be involved in the maintenance of clinical remission. Read More

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http://dx.doi.org/10.3389/fimmu.2018.00907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943505PMC
May 2018
6 Reads

[Primary ophthalmological diagnosis of Treponema pallidum infection: A case series].

Ophthalmologe 2019 Feb;116(2):172-175

Charlottenklinik für Augenheilkunde, Falkertstr. 50, 70176, Stuttgart, Deutschland.

This report is on five patients (four men and one woman) between the age of 24 and 66 years old who presented with unclear visual impairment in our clinic between 2009 and 2016 for co-evaluation. The clinical picture included intermediate uveitis, chorioretinitis, panuveitis and bilateral spontaneous cystoid macular edema. None of the patients reported systemic or dermatological symptoms. Read More

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http://dx.doi.org/10.1007/s00347-018-0712-2DOI Listing
February 2019
10 Reads

Patterns of Uveitis at a Tertiary Referral Center in Northeastern Iran.

J Ophthalmic Vis Res 2018 Apr-Jun;13(2):138-143

Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Purpose: To describe the demographic and clinical patterns of patients with uveitis referred to a tertiary center in northeastern Iran.

Methods: This cross-sectional retrospective study included 235 patients with uveitis who had been referred to the uveitis clinic of Khatam-Al-Anbia eye hospital, affiliated to Mashhad University of Medical Sciences, from February 2013 to March 2014. Data regarding patient age, sex, anatomical location of the disease, and etiologic and clinical features were analyzed. Read More

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http://dx.doi.org/10.4103/jovr.jovr_67_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5905306PMC
May 2018
6 Reads