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J Fr Ophtalmol 2020 Apr 31;43(4):324-329. Epub 2020 Jan 31.

University of Health Science, Beyoglu Eye Training and Research Hospital, Istanbul, Turkey.

Purpose: The objective of this study is to quantitatively analyse the foveal microvasculature in eyes with Fuchs' Uveitic Syndrome (FUS), or Fuchs' Heterochromic Iridocyclitis (FHI), by Optical coherence tomography angiography (OCTA).

Methods: Thirty patients with FUS and 30 healthy volunteer patients (control group) were enrolled in the study. Vascular density (VD) in the superior and deep capillary plexuses (SCP, DCP) were reported and compared between eyes with FUS (FU), fellow eyes (FE) and the control group. Read More

BMC Ophthalmol 2020 Jan 6;20(1):13. Epub 2020 Jan 6.

Harkness Eye Institute, Columbia University Irving Medical Center, New York, NY, 10032, USA.

Background: Bilateral Acute Depigmentation of the Iris (BADI) is a condition which was first described in a case series from Turkey by Tugal-Tutkin and Urgancioglu in (Graefes Arch Clin Exp Ophthalmol 244:742-6, 2006). The condition is characterized by bilateral acute depigmentation and discoloration of the iris stroma, pigment dispersion, and deposition of pigment in the angle. In our case we report a patient who developed BADI after receiving pitcher plant extract injections for chronic migraine, while her identical twin sister has normal iris architecture and pigmentation and never received any pitcher plant injections. Read More

Ocul Immunol Inflamm 2019 Oct 23:1-9. Epub 2019 Oct 23.

Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Ophthalmology Department and Laboratory and DHU Sight Restore , Paris , France.

: To report the clinical features and treatment outcomes in immunocompetent patients with anterior segment inflammation (ASI) related to human cytomegalovirus (HCMV) depending on their ethnic origin. : Multicenter retrospective study of 38 patients with at least one test, either HCMV-positive PCR or GWc. : Features of Posner-Schlossman syndrome were observed in 50% of the eyes, Fuchs heterochromic iridocyclitis in 13% of the eyes, chronic nonspecific anterior uveitis in 21% of the eyes, and corneal endotheliitis in 18% of the eyes. Read More

Ther Adv Ophthalmol 2019 Jan-Dec;11:2515841419869761. Epub 2019 Aug 19.

Eye Unit, Cheltenham and Gloucestershire NHS Foundation Trust, Cheltenham, UK.

Background: Deep sclerectomy offers the potential advantage of less postoperative inflammation and better survival in Fuchs' patients. The aim of this study was to compare survival and safety profiles of Fuchs' heterochromic uveitis patients undergoing trabeculectomy or deep sclerectomy.

Methods: A retrospective study was conducted of two separate cohorts who had undergone either trabeculectomy or deep sclerectomy. Read More

Cornea 2019 Oct;38(10):1299-1304

Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.

Purpose: To evaluate the morphologic appearance of keratic precipitates (KPs) with spectral domain anterior segment optical coherence tomography (AS-OCT) for the diagnosis of uveitic eyes of various etiologies.

Methods: In all, 153 eyes of 153 patients with different types of uveitis were examined to investigate the morphologic appearance of KPs. The study included 63 eyes with herpetic iridocyclitis/endotheliitis, 58 eyes with ocular sarcoidosis, 5 eyes with Fuchs heterochromic iridocyclitis, and 27 eyes with masquerade syndrome with primary intraocular lymphoma (PIOL). Read More

Indian J Ophthalmol 2019 08;67(8):1339

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Invest Ophthalmol Vis Sci 2019 06;60(7):2399-2405

Ophthalmology Department, Reference Center in Rare Diseases, Département Hospitalo Universitaire Sight Restore, Hôpital Pitié Salpêtrière, University Paris VI, Paris, France.

Purpose: To investigate the clinical and virologic-associated and predictive factors of intraocular pressure (IOP) evolution over time and its severity in Fuchs' heterochromic iridocyclitis (FHC).

Methods: Consecutive patients with both clinical FHC and intraocular synthesis of rubella virus (RV)-specific antibodies were included in this study. Specific ocular production of RV antibodies was confirmed using the quotient of serum/aqueous humor ratio of RV IgGs (Crv) and control antiviral IgGs (Cctl), using quantitative serology methods. Read More

Arch Soc Esp Oftalmol 2019 May 28;94(5):209-210. Epub 2019 Mar 28.

Servicio de Oftalmología, Hospital Universitario Ramón y Cajal, Universidad de Alcalá, IRYCIS, Madrid, España. Electronic address:

JAMA Ophthalmol 2019 04;137(4):435-438

Francis I. Proctor Foundation, University of California, San Francisco.

Importance: Metagenomic deep sequencing (MDS) demonstrates that persistent and active rubella virus (RV) infection is associated with Fuchs heterochromic iridocyclitis (FHI).

Objective: To assess the utility of MDS in identifying RV infection in patients with uveitis.

Design, Setting, And Participants: This case series assessed 6 patients diagnosed by MDS with RV-associated uveitis at a tertiary uveitis referral center in the United States. Read More

J BUON 2018 Sep-Oct;23(5):1563-1568

Department of History of Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Born in Vienna, in mid 19th century, Ernst Fuchs became an innovative ophthalmologist and is currently considered as the father of modern ophthalmology. Conditions like heterochromic uveitis and endothelial dystrophy were discovered by Fuchs and a series of ocular diseases are named after him. His work dealing with eye pathology, entitled: "Textbook of Ophthalmology", became known as the masterpiece of the 19th century ophthalmology. Read More

J Fr Ophtalmol 2018 Dec 14;41(10):993-994. Epub 2018 Nov 14.

Service d'ophtalmologie B, hôpital des spécialités, CHU de Rabat, quartier Souissi, 6220 Rabat, Morocco.

F1000Res 2018 22;7:876. Epub 2018 Jun 22.

Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Tehran, 19839-63113, Iran.

The aim of this study was to compare the safety and efficacy of primary trabeculectomy with mitomycin C and Ahmed glaucoma valve (AGV) implantation in patients with Fuchs heterochromic iridocyclitis (FHIC)-related glaucoma, a rare complication of an uncommon form of uveitis. s In this retrospective comparative case series, 26 FHIC-associated glaucoma patients received trabeculectomy (n=12) or an AGV (n=14). Primary outcome measures were surgical success, defined as intraocular pressure (IOP) ≤21 mmHg, decreasing ≥20% from baseline, and no secondary glaucoma surgery. Read More

Adv Biomed Res 2017 28;6:168. Epub 2017 Dec 28.

Department of Ophthalmology, Eye Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran.

In this study, we report a 26-year-old female case of Niemann-Pick disease type C in association with Fuchs heterochromic iridocyclitis who was admitted with the complaint of ocular pain and redness following trauma. She had mild inflammatory signs and also vertical ocular motility limitations. Read More

Ocul Immunol Inflamm 2017 ;25(sup1):S75-S80

a Department of Health Eye Center , East Avenue Medical Center , Quezon City , Philippines.

Purpose: To describe the pattern of uveitis in patients seen at the uveitis clinic of the East Avenue Medical Center, Philippines.

Methods: Clinical records of patients seen from January 2010 to June 2015 were reviewed. Data collected included demographics, clinical presentation, associated systemic disease, work-up, and diagnosis. Read More

Clin Ophthalmol 2017 22;11:1549-1555. Epub 2017 Aug 22.

Department of Clinical Neuroscience/Ophthalmology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Purpose: To evaluate the outcome of cataract surgery in adult patients with uveitis.

Materials And Methods: In this retrospective cohort study, medical charts of patients with uveitis and matched control patients without uveitis who underwent cataract surgery at the Eye Clinic, Sahlgrenska University Hospital, Mölndal, between January 2005 and December 2009 were analyzed.

Results: The study included 58 eyes with and 283 eyes without uveitis. Read More

Eurasian J Med 2017 Jun;49(2):97-101

Department of Ophthalmology, Atatürk University School of Medicine, Erzurum, Turkey.

Objective: To evaluate the efficacy of phacoemulsification combined with posterior capsulorhexis, core vitrectomy and ciliary sulcus intraocular lens (IOL) implantation in patients with Fuchs' heterochromic uveitis (FHU).

Materials And Methods: A total of 18 eyes of 18 patients with FHU underwent cataract surgery were included in the study. 18 eyes with FHU underwent posterior capsulorhexis, core vitrectomy and poly (methyl methacrylate) (PMMA) IOL implantation in the ciliary sulcus. Read More

Arq Bras Oftalmol 2017 Mar-Apr;80(2):104-107

Departament of Ophthalmology, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.

Purpose:: To evaluate the outcomes of phacoemulsification with intraocular lens (IOL) implantation in eyes with uveitis.

Methods:: Consecutive patients with uveitis and cataracts who had phacoemulsification and acrylic IOL implantation during 2007-2012 were evaluated for visual outcomes, etiology, and complications. Inflammation was controlled for at least 3 months before surgery, and oral prednisone (0. Read More

J Ocul Pharmacol Ther 2017 05 20;33(4):313-318. Epub 2017 Apr 20.

1 Department of Ophthalmology, Saint Pierre Hospital , Université Libre de Bruxelles, Brussels, Belgium .

Purpose: To study the effects of topical ganciclovir 0.15% gel on cytomegalovirus (CMV) anterior uveitis in a tertiary uveitis referral center in Brussels, Belgium.

Methods: A retrospective study of patients with a clinical diagnosis of CMV anterior uveitis/endotheliitis demonstrated by a positive polymerase chain reaction and/or Goldmann-Witmer coefficient (GWc). Read More

J Clin Diagn Res 2016 Dec 1;10(12):NC13-NC16. Epub 2016 Dec 1.

Tutor Demonstrator, Department of Forensic Medicine, SKIMS, Medical College , Bemina, Srinagar, India .

Introduction: Fuchs Heterochromic Iridocylitis (FHI) is a rare form of uveitis which is frequently complicated by cataract and glaucoma, but it does not show typical features of uveitis like pain, redness and posterior synechia.

Aim: To study the clinical characteristics and outcome of cataract extraction with Intra Ocular Lens (IOL) implantation in patients with FHI.

Materials And Methods: The present prospective study was carried out in the Postgraduate Department of Ophthalmology, Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Bemina from March 2012 to January 2015. Read More

Int J Retina Vitreous 2017 23;3. Epub 2017 Jan 23.

Servicio de Retina y Vítreo, Hospital Luis Sánchez Bulnes, Asociación para Evitar la Ceguera en México, I.A.P, Vicente García Torres 46, Colonia Barrio San Lucas, 04030 Coyoacan, Mexico City, Mexico.

Background: Classic retinitis pigmentosa (RP) and other syndromic variants have previously been associated to Fuchs' heterochromic iridocyclitis (FHI). Common immunogenic and inflammatory pathways have been proposed to explain the higher incidence of this uveitic phenomenon in patients with retinal dystrophies without definitive answers. Infrequent variants of RP such as inverse RP have not been previously reported in association with FHI. Read More

J Ophthalmol 2016 3;2016:1458624. Epub 2016 Oct 3.

Department of Ophthalmology, Sapienza University of Rome, Rome, Italy.

. To study epidemiology, clinical findings and visual prognosis of patients with Fuchs' Heterochromic Iridocyclitis (FHI). . Read More

Graefes Arch Clin Exp Ophthalmol 2016 Oct 2;254(10):2025-2031. Epub 2016 Sep 2.

Department of Biomedical and Surgical Sciences, Section of Ophthalmology, University of Perugia, S. Maria della Misericordia Hospital, Perugia, 06156, Italy.

Purpose: To perform a quantitative analysis of choroidal thickness in patients with Fuchs Uveitis Syndrome (FUS) using enhanced depth imaging optical coherence tomography (EDI-OCT).

Methods: All patients underwent comprehensive ophthalmic examination, including best-corrected visual acuity, slit-lamp biomicroscopy, applanation tonometry, axial length measurements with a swept-source biometer (IOLMaster 700, Carl Zeiss Medic AG, Jena, Germany) and macular 30° linear EDI- B-scan SD-OCT section (Spectralis HRAII+OCT, Heidelberg Engineering, Heidelberg, Germany) in both eyes. Analysis of choroidal thickness was performed at three different locations: subfoveally, 750 μm nasally, and 750 μm temporally to the fovea. Read More

Ocul Immunol Inflamm 2017 Dec 5;25(6):753-759. Epub 2016 Aug 5.

b Eye Surgery Associates , Melbourne , Victoria , Australia.

Purpose: To describe the incidence and risk factors for ocular hypertension and/or glaucoma in patients with Fuchs heterochromic iridocyclitis (FHC).

Methods: Retrospective analysis of 88 patients with FHC. Kaplan-Meier curves estimated the time to develop cataract and ocular hypertension/glaucoma. Read More

Eye (Lond) 2016 Jun 8;30(6):865-72. Epub 2016 Apr 8.

Medical Retina and Uveitis Department, Moorfields Eye Hospital NHS Foundation Trust, London, UK.

PurposeTo develop and validate a Bayesian belief network algorithm for the differential diagnosis of anterior uveitis.Patients and methodsThe 11 most common etiologies were included (idiopathic, ankylosing spondylitis, psoriasic arthritis, reactive arthritis, inflammatory bowel diseases, sarcoidosis, tuberculosis, Behçet, Posner-Schlossman syndrome, juvenile idiopathic arthritis (JIA), and Fuchs' heterochromic cyclitis). Frequencies of association between factors and etiologies were retrieved from a systematic review of the literature. Read More

Asia Pac J Ophthalmol (Phila) 2016 Sep-Oct;5(5):330-4

From the Departments of *Ophthalmology and †Pathology, School of Medical Sciences and Research, Sharda University, Greater Noida; and ‡Department of Ophthalmology, Rotary Eye Hospital, Maranda, Palampur, India.

Purpose: To compare the safety and efficacy of phacoemulsification and manual small incision cataract surgery (SICS) to treat cataract in patients with Fuchs heterochromic iridocyclitis (FHI).

Design: A randomized, double-masked, prospective, multicenter study.

Methods: Consecutive patients with cataract after FHI were randomly assigned to have phacoemulsification or manual SICS by 1 of 2 surgeons experienced in both techniques. Read More

Ocul Immunol Inflamm 2017 Jun 25;25(3):382-387. Epub 2016 Feb 25.

a Department of Ophthalmology, São Paulo Hospital, Escola Paulista de Medicina , Federal University of São Paulo , Brazil.

Purpose: To describe the clinical profile of uveitis and analyze changes over a 34-year period in the frequency of different entities and demographics, anatomic data, diagnoses, and systemic associations in São Paulo, Brazil.

Methods: A total of 1053 consecutive patients who presented for the first time at the outpatient uveitis clinic were analyzed in a prospective, observational study, conducted between July 2012 and September 2013. Age, gender, clinical characteristics, visual acuity, and clinical and etiologic diagnoses in patients with and without human immunodeficiency virus (HIV) were studied. Read More

Br J Ophthalmol 2016 10 12;100(10):1397-402. Epub 2016 Jan 12.

Retinal Department, Shanxi Eye Hospital, Taiyuan, Shanxi Province, China Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA.

Aims: To explore the characteristic autofluorescence patterns of iris depigmentation in eyes diagnosed with Fuchs' heterochromic uveitis (FHU).

Methods: Near-infrared autofluorescence images and colour images of iris were taken in 21 eyes of 21 patients with FHU, 30 eyes of 15 normal subjects, 30 eyes of 15 normal age-related iris atrophy and 33 eyes of 20 patients with uveitis other than FHU. The confocal scanning laser ophthalmoscope (Heidelberg Retina Angiograph 2, HRA2) was used for melanin-related autofluorescence imaging. Read More

J Med Case Rep 2015 Mar 15;9:60. Epub 2015 Mar 15.

Department of Ophthalmology and Visual Sciences, University of Alberta, Room 2319, 10240 Kingsway Avenue, Edmonton, AB, T5H 3V9, Canada.

Introduction: Usher syndrome is a genetically heterogeneous condition and represents the most common cause of inherited combined vision and hearing loss. Deficits manifest as sensorineural hearing loss that typically develops at a young age and retinitis pigmentosa that can lead to peripheral vision loss and night blindness. As a result, this syndrome can have a significant impact on a patient's quality of life. Read More

J Ophthalmic Inflamm Infect 2015 2;5:10. Epub 2015 Apr 2.

Department of Ophthalmology, The Alfred, 55 Commercial Road, Melbourne, Victoria 3004 Australia.

Background: Improvement in surgical devices and intraocular lenses has made modern cataract surgery a safe procedure with decreasing complication rates. Intraocular lens dislocation is a serious complication after cataract surgery. Although most dislocations occur during the first week postoperative period, late intraocular lens dislocation occurring 3 months or later post-surgery has been reported with increasing frequency in recent years as a result of progressive zonular dehiscence. Read More

Nepal J Ophthalmol 2014 Jul-Dec;6(2):153-61

Department of Ophthalmology, Santosh Medical College and Hospital, Ghaziabad.

Introduction: Fuch's heterochromic iridocyclitis (FHI) is often complicated by cataract formation.

Objective: To assess the results of small-incision cataract surgery (SICS) in FHI and to study the effect of preoperative factors on postoperative vision.

Materials And Methods: Sixty-three eyes of 59 patients with Fuchs heterochromic iridocyclitis who had SICS with in-the-bag implantation of intraocular lens (IOL) were evaluated retrospectively; and the primary and secondary outcome measures evaluated were the postoperative vision and complication rate. Read More

Ocul Immunol Inflamm 2015 10;23(5):378-83. Epub 2014 Sep 10.

b National Healthcare Group Eye Institute, Tan Tock Seng Hospital , Singapore.

Purpose: To present the clinical characteristics of patients with anterior uveitis who had evidence of cytomegalovirus (CMV) infection on polymerase chain reaction PCR-based assays for viral DNA in aqueous samples.

Methods: This was a retrospective observational case series of 16 patients with CMV infection on qualitative polymerase chain reaction PCR-based assays for viral DNA in aqueous samples. Case records of 16 patients were reviewed and relevant clinical information was collected using a standardized data sheet. Read More

Am J Ophthalmol 2014 Oct 28;158(4):676-692.e7. Epub 2014 Jun 28.

Ocular Inflammation Service, Department of Ophthalmology, Scheie Eye Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Department of Biostatistics & Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

Purpose: To critically assess the evidence base regarding outcomes following cataract surgery in uveitic cases.

Design: Systematic evidence-based review and meta-analysis.

Methods: A comprehensive search query was performed on MEDLINE, EMBASE, CINHAL, and CENTRAL databases. Read More

Ocul Immunol Inflamm 2016 19;24(1):113-4. Epub 2014 Jun 19.

a Department of Ophthalmology , Erasmus MC, University Medical Center Rotterdam , Rotterdam , The Netherlands , and.

Rubella virus is involved in the pathogenesis of Fuchs heterochromic uveitis and almost all cases in Europe show an active antibody production in the aqueous humor against rubella virus. Herein we report a case of a fully vaccinated patient with common variable immunodeficiency who developed unilateral Fuchs heterochromic uveitis secondary to rubella virus which was proven by intraocular fluid examination. Awareness of rubella associated anterior uveitis should remain also in vaccinated patients, especially those without a fully competent immune system. Read More

Ocul Immunol Inflamm 2015 Aug 16;23(4):278-282. Epub 2014 Apr 16.

d Department of Ophthalmology , School of Medicine, Shahid Beheshti University of Medical Sciences , Tehran , Iran.

Purpose: This study aimed to analyze the clinical patterns and etiology of uveitis in Isfahan, Iran.

Methods: In this descriptive research, the records of 2016 patients with uveitis referred to a tertiary eye care centers were examined. Age, sex, clinical and anatomical features, and etiology of disease were recorded and analyzed. Read More

Can J Ophthalmol 2014 Feb;49(1):e11-4

The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Clin Ophthalmol 2014 10;8:199-214. Epub 2014 Jan 10.

Department of Ophthalmology, University of Ioannina, Ioannina, Greece.

Purpose: Uveitis is the inflammation of the uveal tract, which usually also affects the retina and vitreous humor. The electrophysiological examination is an objective ocular examination that includes the electroretinogram, visual evoked potentials, the electrooculogram, the multifocal electroretinogram, and multifocal visual evoked potentials. Our aim is to review the literature of the use of the electrophysiological examination in cases of uveitis. Read More

Ocul Immunol Inflamm 2015 Apr 2;23(2):118-26. Epub 2013 Dec 2.

The Royal Eye Hospital , Manchester , UK.

Purpose: To demonstrate the demography, anatomical, and diagnostic classification of patients with uveitis attending the Manchester Uveitis Clinic (MUC), a specialist uveitis clinic in the northwest of England, UK.

Methods: Retrospective retrieval of data on a computerized database incorporating all new referrals to MUC from 1991 to 2013.

Results: A total of 3000 new patients with uveitis were seen during a 22-year period. Read More

Clin Ophthalmol 2013 30;7:2107-11. Epub 2013 Oct 30.

Uveitis Services, Department of Ophthalmology, King Abdulaziz University, Jeddah, Saudi Arabia ; Magrabi Eye and Ear Hospital, Jeddah, Saudi Arabia.

Background: The association of human leukocyte antigen B27 (HLA-B27) with anterior uveitis is well known. The prevalence of HLA-B27 and its relation to anterior uveitis is related to race and geographic location. The association is strongest in Western countries and weakest in Eastern countries. Read More

J Ophthalmic Inflamm Infect 2013 Jul 9;3(1):55. Epub 2013 Jul 9.

Vittala International Institute of Ophthalmology, Bangalore, India.

Background: The aim of this study is to report two interesting cases of cytomegalovirus (CMV) anterior uveitis following topical prostaglandin analogue administration for glaucoma. Two retrospective case studies are presented.

Findings: A 40-year-old immunocompetent lady with a history of Fuchs heterochromic iridocyclitis with secondary glaucoma in the right eye since 2005 was diagnosed to have CMV anterior uveitis by a multiplex polymerase chain reaction (PCR) in 2009. Read More

Arch Soc Esp Oftalmol 2013 Jul 10;88(7):283-5. Epub 2012 Nov 10.

Servicio de Oftalmología, Hospital Do Salnés, Vilagarcía de Arousa, Pontevedra, España.

Case Report: A case of unilateral iridis hyperpigmentation and uveitis due to travoprost is presented.

Discussion: Anterior uveitis is a rare side-effect of travoprost. In this case, heterochromic iris was also presented, which led us to the wrong diagnosis of a Fuchs heterochromic iridocyclitis. Read More

J Cataract Refract Surg 2013 Jul 18;39(7):1002-7. Epub 2013 May 18.

Ophthalmology Department, Yozgat State Hospital, Yozgat, Ankara, Turkey.

Purpose: To assess the results of phacoemulsification and posterior chamber intraocular lens (PC IOL) implantation in patients with cataract secondary to anterior uveitis.

Setting: Department of Ophthalmology, Ministry of Health, Ankara Training and Research Hospital, Ankara, Turkey.

Design: Case series. Read More

Ocul Immunol Inflamm 2013 Aug 25;21(4):270-5. Epub 2013 Apr 25.

National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore.

Purpose: To report the trends in etiology of patients with anterior uveitis (AU) in Singapore over 6 years.

Methods: A retrospective review of the clinical records of all new patients who presented with anterior uveitis to the uveitis subspecialty clinic from 2005 to 2010 at Tan Tock Seng Hospital, Singapore.

Results: There were 552 new cases of AU. Read More

Indian J Ophthalmol 2014 Mar;62(3):373-4

Department of Ophthalmology, Farabi Eye Hospital, Eye Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Implantation of iris-claw Artisan intraocular lens (IOL) is a surgical option for correction of aphakia; however, these IOLs have not been used in eyes with uveitis including Fuchs' heterochromic iridocyclitis (FHI) due to possible risk of severe postoperative intraocular inflammation. In the case reported here, we secondarily implanted an Artisan IOL in a 28-year-old man with FHI who had aphakia with no capsular support due to a previous complicated cataract surgery. Enclavation was easily performed and no intraoperative complication was noted. Read More

Graefes Arch Clin Exp Ophthalmol 2013 Jul 22;251(7):1785-90. Epub 2013 Mar 22.

Department of Ophthalmology, First Affiliated Hospital, Wenzhou Medical College, Wenzhou, Zhejiang, 325000, People's Republic of China.

Purpose: To access surgical effects in patients with secondary glaucoma in Fuchs' heterochromic iridocyclitis.

Methods: We had employed medical or surgical treatment for 22 patients who had been diagnosed as secondary glaucoma and Fuchs' heterochromic iridocyclitis. Thirteen patients had undergone trabeculectomy with intraoperative applications of mitomycin C (MMC), of whom 11 patients had been followed up postoperatively for 25. Read More

J Ophthalmic Inflamm Infect 2013 Jan 15;3(1):14. Epub 2013 Jan 15.

Department of Uveitis & Intraocular Inflammation, Vittala International Institute of Ophthalmology, Bangalore, 560085, India.

Background: The purpose of this study is to look for any possible associations in 58 consecutive cases of Fuchs heterochromic iridocyclitis (FHI) in a South Indian patient population. Fifty-eight consecutive cases (59 eyes) of FHI underwent a detailed ocular and systemic evaluation. Routine laboratory investigations for uveitis including serum angiotensin-converting enzyme and enzyme-linked immunosorbent assay (ELISA) for toxoplasmosis (IgG and IgM) were done in all the cases. Read More

Ophthalmic Genet 2014 Jun 6;35(2):63-7. Epub 2013 Mar 6.

The First Affiliated Hospital of Chongqing Medical University , Chongqing , P.R. China , and.

Purpose: This study was performed to evaluate the potential association of the tumor necrosis factor alpha inducible protein 3gene (TNFAIP3) polymorphisms with Fuchs' heterochromic iridocyclitis (Fuchs' Syndrome) in a Chinese Han population.

Methods: Five single-nucleotide polymorphisms (SNPs), rs10499194, rs610604, rs7753873, rs5029928 and rs9494885 of TNFAIP3 were genotyped in 225 Fuchs' syndrome patients and 651 healthy controls using a PCR-restriction fragment length polymorphism assay. All control subjects were matched ethnically and geographically with the patients. Read More

Mol Vis 2012 1;18:2909-14. Epub 2012 Dec 1.

Eye Hospital, University Clinical Center Ljubljana, Slovenia.

Purpose: To prospectively study the relationship between Fuchs heterochromic uveitis syndrome (FHUS) and intraocular production of specific antibodies against the rubella virus (RV) in Slovenia.

Methods: Using the Goldmann-Witmer coefficient technique, intraocular synthesis of specific antibodies against RV, herpes simplex virus, varicella-zoster virus, cytomegalovirus (CMV) and Toxoplasma gondii-specific immunoglobulin G antibodies was performed in 12 consecutive patients with clinically diagnosed FHUS and 12 patients with idiopathic recurrent unilateral anterior uveitis (AU) without clinical features of FHUS.

Results: Specific intraocular antibody synthesis against RV with a positive Goldmann-Witmer coefficient was proven in 11 of 12 (92%) FHUS patients, and in none of the non-FHUS AU patients (Fisher's exact test <0. Read More

Int Ophthalmol 2013 Apr 16;33(2):189-94. Epub 2012 Oct 16.

Department of Ophthalmology, Pitie-Salpetriere Hospital, 47 bd de l'Hôpital, Paris, France.

The purpose of this article is to report the development of Fuchs' heterochromic cyclitis (FHC) secondary to toxoplasmosis chorioretinitis. The design is based on observational case series report. We report in this article six cases of typical FHC developing secondary to ocular toxoplasmosis. Read More

Eye (Lond) 2012 Apr 13;26(4):529-34. Epub 2012 Jan 13.

Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.

Aims: To assess the possible role of virus infection in patients with unexplained anterior uveitis (AU).

Methods: Intraocular fluid and plasma samples of 30 HIV-negative AU patients who were unresponsive or poorly responsive to topical steroid therapy were analyzed for nucleic acid of cytomegalovirus (CMV), herpes simplex virus (HSV), and varicella zoster virus (VZV) by real-time polymerase chain reaction (PCR) and for intraocular antibodies against these viruses by Goldmann-Witmer coefficient (GWC) analysis. Of these 30 cases, 21 were tested for rubella virus by GWC analysis, 16 of which also had PCR assessment of aqueous for rubella virus. Read More