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J Ophthalmic Vis Res 2021 Jan-Mar;16(1):93-102. Epub 2021 Jan 20.

Department of Ophthalmology, Nikookari Eye Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Purpose: Uveitis is the third leading cause of blindness worldwide. This study aimed to summarize the pattern of uveitis in Iran through a systematic review.

Methods: This review was conducted according to the guidelines for systematic reviews in the following four steps: literature search, study selection and assessment, inclusion and exclusion criteria, and statistical analysis. Read More

Indian J Ophthalmol 2020 09;68(9):2057-2058

Cornea and Anterior Segment Services, L V Prasad Eye Institute, Hyderabad, Telangana, India.

Indian J Ophthalmol 2020 09;68(9):2057

Department of Cataract and Refractive Surgery, Anand Eye Institute, Hyderabad, Telangana, India.

Eur J Ophthalmol 2020 Aug 17:1120672120950932. Epub 2020 Aug 17.

Dünyagöz Hospital, Ankara, Turkey.

Purpose: To evaluate the prevalence of uveitic glaucoma (UG) in the Turkish population and investigate the primary underlying diseases.

Methods: This multicenter, cross-sectional, prospective study included patients who presented to the glaucoma units of 10 tertiary ophthalmology departments in Ankara, Turkey from 15th March to 16th May 2015 and fulfilled the criteria of UG. Patients were inspected for age, sex, medical history, best corrected visual acuity, biomicroscopic findings, intraocular pressure values, and visual field results. Read More

Indian J Ophthalmol 2020 03;68(3):447-449

Cornea and Anterior Segment Services, L V Prasad Eye Institute, Hyderabad, Telangana, India.

Purpose: To assess the corneal endothelium in patients with Fuchs heterochromic iridocyclitis (FHI) and compare it with the normal fellow eye.

Methods: Retrospective, observational, cross-sectional study of 31 patients seen between Jan 2016 to Dec 2018, with clinical diagnosis of Fuchs heterochromic iridocyclitis, was performed. Specular microscopic examination was documented in both eyes. Read More

J Fr Ophtalmol 2020 Apr 31;43(4):324-329. Epub 2020 Jan 31.

University of Health Science, Beyoglu Eye Training and Research Hospital, Istanbul, Turkey.

Purpose: The objective of this study is to quantitatively analyse the foveal microvasculature in eyes with Fuchs' Uveitic Syndrome (FUS), or Fuchs' Heterochromic Iridocyclitis (FHI), by Optical coherence tomography angiography (OCTA).

Methods: Thirty patients with FUS and 30 healthy volunteer patients (control group) were enrolled in the study. Vascular density (VD) in the superior and deep capillary plexuses (SCP, DCP) were reported and compared between eyes with FUS (FU), fellow eyes (FE) and the control group. Read More

BMC Ophthalmol 2020 Jan 6;20(1):13. Epub 2020 Jan 6.

Harkness Eye Institute, Columbia University Irving Medical Center, New York, NY, 10032, USA.

Background: Bilateral Acute Depigmentation of the Iris (BADI) is a condition which was first described in a case series from Turkey by Tugal-Tutkin and Urgancioglu in (Graefes Arch Clin Exp Ophthalmol 244:742-6, 2006). The condition is characterized by bilateral acute depigmentation and discoloration of the iris stroma, pigment dispersion, and deposition of pigment in the angle. In our case we report a patient who developed BADI after receiving pitcher plant extract injections for chronic migraine, while her identical twin sister has normal iris architecture and pigmentation and never received any pitcher plant injections. Read More

Int Ophthalmol 2020 Apr 3;40(4):795-802. Epub 2019 Dec 3.

Ulucanlar Eye Education and Research Hospital, University of Health Sciences, Ulucanlar caddesi No:59, 06240, Altindag, Ankara, Turkey.

Purpose: To investigate the outcome of mitomycin C (MMC)-augmented trabeculectomy with subconjunctival bevacizumab in the management of Fuchs heterochromic iridocyclitis (FHI)-related glaucoma in 1-year follow-up period.

Methods: This retrospective study included 50 eyes with FHI-related glaucoma those had underwent initial trabeculectomy with MMC (0.2 mg/ml-3 min). Read More

Ocul Immunol Inflamm 2021 Jan 23;29(1):160-168. Epub 2019 Oct 23.

Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Ophthalmology Department and Laboratory and DHU Sight Restore, Paris, France.

: To report the clinical features and treatment outcomes in immunocompetent patients with anterior segment inflammation (ASI) related to human cytomegalovirus (HCMV) depending on their ethnic origin.: Multicenter retrospective study of 38 patients with at least one test, either HCMV-positive PCR or GWc.: Features of Posner-Schlossman syndrome were observed in 50% of the eyes, Fuchs heterochromic iridocyclitis in 13% of the eyes, chronic nonspecific anterior uveitis in 21% of the eyes, and corneal endotheliitis in 18% of the eyes. Read More

Ther Adv Ophthalmol 2019 Jan-Dec;11:2515841419869761. Epub 2019 Aug 19.

Eye Unit, Cheltenham and Gloucestershire NHS Foundation Trust, Cheltenham, UK.

Background: Deep sclerectomy offers the potential advantage of less postoperative inflammation and better survival in Fuchs' patients. The aim of this study was to compare survival and safety profiles of Fuchs' heterochromic uveitis patients undergoing trabeculectomy or deep sclerectomy.

Methods: A retrospective study was conducted of two separate cohorts who had undergone either trabeculectomy or deep sclerectomy. Read More

Cornea 2019 Oct;38(10):1299-1304

Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan.

Purpose: To evaluate the morphologic appearance of keratic precipitates (KPs) with spectral domain anterior segment optical coherence tomography (AS-OCT) for the diagnosis of uveitic eyes of various etiologies.

Methods: In all, 153 eyes of 153 patients with different types of uveitis were examined to investigate the morphologic appearance of KPs. The study included 63 eyes with herpetic iridocyclitis/endotheliitis, 58 eyes with ocular sarcoidosis, 5 eyes with Fuchs heterochromic iridocyclitis, and 27 eyes with masquerade syndrome with primary intraocular lymphoma (PIOL). Read More

Indian J Ophthalmol 2019 08;67(8):1339

Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Invest Ophthalmol Vis Sci 2019 06;60(7):2399-2405

Ophthalmology Department, Reference Center in Rare Diseases, Département Hospitalo Universitaire Sight Restore, Hôpital Pitié Salpêtrière, University Paris VI, Paris, France.

Purpose: To investigate the clinical and virologic-associated and predictive factors of intraocular pressure (IOP) evolution over time and its severity in Fuchs' heterochromic iridocyclitis (FHC).

Methods: Consecutive patients with both clinical FHC and intraocular synthesis of rubella virus (RV)-specific antibodies were included in this study. Specific ocular production of RV antibodies was confirmed using the quotient of serum/aqueous humor ratio of RV IgGs (Crv) and control antiviral IgGs (Cctl), using quantitative serology methods. Read More

Arch Soc Esp Oftalmol (Engl Ed) 2019 May 28;94(5):209-210. Epub 2019 Mar 28.

Servicio de Oftalmología, Hospital Universitario Ramón y Cajal, Universidad de Alcalá, IRYCIS, Madrid, España. Electronic address:

JAMA Ophthalmol 2019 04;137(4):435-438

Francis I. Proctor Foundation, University of California, San Francisco.

Importance: Metagenomic deep sequencing (MDS) demonstrates that persistent and active rubella virus (RV) infection is associated with Fuchs heterochromic iridocyclitis (FHI).

Objective: To assess the utility of MDS in identifying RV infection in patients with uveitis.

Design, Setting, And Participants: This case series assessed 6 patients diagnosed by MDS with RV-associated uveitis at a tertiary uveitis referral center in the United States. Read More

J BUON 2018 Sep-Oct;23(5):1563-1568

Department of History of Medicine, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Born in Vienna, in mid 19th century, Ernst Fuchs became an innovative ophthalmologist and is currently considered as the father of modern ophthalmology. Conditions like heterochromic uveitis and endothelial dystrophy were discovered by Fuchs and a series of ocular diseases are named after him. His work dealing with eye pathology, entitled: "Textbook of Ophthalmology", became known as the masterpiece of the 19th century ophthalmology. Read More

J Fr Ophtalmol 2018 Dec 14;41(10):993-994. Epub 2018 Nov 14.

Service d'ophtalmologie B, hôpital des spécialités, CHU de Rabat, quartier Souissi, 6220 Rabat, Morocco.

F1000Res 2018 22;7:876. Epub 2018 Jun 22.

Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Tehran, 19839-63113, Iran.

The aim of this study was to compare the safety and efficacy of primary trabeculectomy with mitomycin C and Ahmed glaucoma valve (AGV) implantation in patients with Fuchs heterochromic iridocyclitis (FHIC)-related glaucoma, a rare complication of an uncommon form of uveitis. s In this retrospective comparative case series, 26 FHIC-associated glaucoma patients received trabeculectomy (n=12) or an AGV (n=14). Primary outcome measures were surgical success, defined as intraocular pressure (IOP) ≤21 mmHg, decreasing ≥20% from baseline, and no secondary glaucoma surgery. Read More

Adv Biomed Res 2017 28;6:168. Epub 2017 Dec 28.

Department of Ophthalmology, Eye Research Centre, Isfahan University of Medical Sciences, Isfahan, Iran.

In this study, we report a 26-year-old female case of Niemann-Pick disease type C in association with Fuchs heterochromic iridocyclitis who was admitted with the complaint of ocular pain and redness following trauma. She had mild inflammatory signs and also vertical ocular motility limitations. Read More

Ocul Immunol Inflamm 2017 ;25(sup1):S75-S80

a Department of Health Eye Center , East Avenue Medical Center , Quezon City , Philippines.

Purpose: To describe the pattern of uveitis in patients seen at the uveitis clinic of the East Avenue Medical Center, Philippines.

Methods: Clinical records of patients seen from January 2010 to June 2015 were reviewed. Data collected included demographics, clinical presentation, associated systemic disease, work-up, and diagnosis. Read More

Clin Ophthalmol 2017 22;11:1549-1555. Epub 2017 Aug 22.

Department of Clinical Neuroscience/Ophthalmology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Purpose: To evaluate the outcome of cataract surgery in adult patients with uveitis.

Materials And Methods: In this retrospective cohort study, medical charts of patients with uveitis and matched control patients without uveitis who underwent cataract surgery at the Eye Clinic, Sahlgrenska University Hospital, Mölndal, between January 2005 and December 2009 were analyzed.

Results: The study included 58 eyes with and 283 eyes without uveitis. Read More

Eurasian J Med 2017 Jun;49(2):97-101

Department of Ophthalmology, Atatürk University School of Medicine, Erzurum, Turkey.

Objective: To evaluate the efficacy of phacoemulsification combined with posterior capsulorhexis, core vitrectomy and ciliary sulcus intraocular lens (IOL) implantation in patients with Fuchs' heterochromic uveitis (FHU).

Materials And Methods: A total of 18 eyes of 18 patients with FHU underwent cataract surgery were included in the study. 18 eyes with FHU underwent posterior capsulorhexis, core vitrectomy and poly (methyl methacrylate) (PMMA) IOL implantation in the ciliary sulcus. Read More

Arq Bras Oftalmol 2017 Mar-Apr;80(2):104-107

Departament of Ophthalmology, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil.

Purpose:: To evaluate the outcomes of phacoemulsification with intraocular lens (IOL) implantation in eyes with uveitis.

Methods:: Consecutive patients with uveitis and cataracts who had phacoemulsification and acrylic IOL implantation during 2007-2012 were evaluated for visual outcomes, etiology, and complications. Inflammation was controlled for at least 3 months before surgery, and oral prednisone (0. Read More

J Ocul Pharmacol Ther 2017 05 20;33(4):313-318. Epub 2017 Apr 20.

1 Department of Ophthalmology, Saint Pierre Hospital , Université Libre de Bruxelles, Brussels, Belgium .

Purpose: To study the effects of topical ganciclovir 0.15% gel on cytomegalovirus (CMV) anterior uveitis in a tertiary uveitis referral center in Brussels, Belgium.

Methods: A retrospective study of patients with a clinical diagnosis of CMV anterior uveitis/endotheliitis demonstrated by a positive polymerase chain reaction and/or Goldmann-Witmer coefficient (GWc). Read More

J Clin Diagn Res 2016 Dec 1;10(12):NC13-NC16. Epub 2016 Dec 1.

Tutor Demonstrator, Department of Forensic Medicine, SKIMS, Medical College , Bemina, Srinagar, India .

Introduction: Fuchs Heterochromic Iridocylitis (FHI) is a rare form of uveitis which is frequently complicated by cataract and glaucoma, but it does not show typical features of uveitis like pain, redness and posterior synechia.

Aim: To study the clinical characteristics and outcome of cataract extraction with Intra Ocular Lens (IOL) implantation in patients with FHI.

Materials And Methods: The present prospective study was carried out in the Postgraduate Department of Ophthalmology, Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Bemina from March 2012 to January 2015. Read More

Int J Retina Vitreous 2017 23;3. Epub 2017 Jan 23.

Servicio de Retina y Vítreo, Hospital Luis Sánchez Bulnes, Asociación para Evitar la Ceguera en México, I.A.P, Vicente García Torres 46, Colonia Barrio San Lucas, 04030 Coyoacan, Mexico City, Mexico.

Background: Classic retinitis pigmentosa (RP) and other syndromic variants have previously been associated to Fuchs' heterochromic iridocyclitis (FHI). Common immunogenic and inflammatory pathways have been proposed to explain the higher incidence of this uveitic phenomenon in patients with retinal dystrophies without definitive answers. Infrequent variants of RP such as inverse RP have not been previously reported in association with FHI. Read More

J Ophthalmol 2016 3;2016:1458624. Epub 2016 Oct 3.

Department of Ophthalmology, Sapienza University of Rome, Rome, Italy.

. To study epidemiology, clinical findings and visual prognosis of patients with Fuchs' Heterochromic Iridocyclitis (FHI). . Read More

Graefes Arch Clin Exp Ophthalmol 2016 Oct 2;254(10):2025-2031. Epub 2016 Sep 2.

Department of Biomedical and Surgical Sciences, Section of Ophthalmology, University of Perugia, S. Maria della Misericordia Hospital, Perugia, 06156, Italy.

Purpose: To perform a quantitative analysis of choroidal thickness in patients with Fuchs Uveitis Syndrome (FUS) using enhanced depth imaging optical coherence tomography (EDI-OCT).

Methods: All patients underwent comprehensive ophthalmic examination, including best-corrected visual acuity, slit-lamp biomicroscopy, applanation tonometry, axial length measurements with a swept-source biometer (IOLMaster 700, Carl Zeiss Medic AG, Jena, Germany) and macular 30° linear EDI- B-scan SD-OCT section (Spectralis HRAII+OCT, Heidelberg Engineering, Heidelberg, Germany) in both eyes. Analysis of choroidal thickness was performed at three different locations: subfoveally, 750 μm nasally, and 750 μm temporally to the fovea. Read More