34,984 results match your criteria Uveitis Fuchs Heterochromic


Association Between Noninfectious Uveitis and Psychological Stress.

JAMA Ophthalmol 2018 Dec 6. Epub 2018 Dec 6.

Francis I. Proctor Foundation, University of California, San Francisco.

Importance: Uveitis involves dysregulation of the ocular immune system. Stress has been shown to affect immune function, but it is unclear whether there is an association between stress and uveitis.

Objective: To determine whether having uveitis is associated with psychological stress. Read More

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December 2018
2 Reads

Macular serpiginous choroiditis - case report.

Rom J Ophthalmol 2018 Jul-Sep;62(3):217-221

Anatomy Department, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

Serpiginous choroiditis represents an inflammation, often asymmetric, situated at the level of the inner choroid, which is related to the retinal pigment epithelium and the choriocapillaris. It is known as a primarily idiopathic, but there are authors who consider it an autoimmune process. Many times, fundus autofluorescence is the investigation which is guiding the diagnosis, the management, also the follow-up together with the determination of the progressive visual prognosis. Read More

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December 2018

Similarities and differences between three different types of white dot syndrome and the therapeutic possibilities.

Rom J Ophthalmol 2018 Jul-Sep;62(3):183-187

Anatomy Department, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.

White dot syndromes consists a group of inflammatory eye diseases with an unknown etiology involving the external retina, retinal pigment epithelium, choroid or combinations of them. They affect one or both eyes, at the same time or not. White dot syndromes are often self-limited, with a variable prognosis, depending on the type of the disease. Read More

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December 2018

Intravitreal Dexamethasone Implant in the Treatment of Non-Infectious Uveitic Macular Edema.

Med Hypothesis Discov Innov Ophthalmol 2018 ;7(4):169-175

Department of Ophthalmology, Dokuz Eylul University, İzmir, Turkey.

Macular Edema (ME) is a common complication, leading to severe vision loss in patients with Non-Infectious Uveitis (NIU). The treatment of uveitic ME is still very challenging for many ophthalmologists. Various agents, such as corticosteroids, anti-vascular endothelial growth factors, and immune-modulators, have been used for combatting uveitic ME. Read More

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January 2018

A Review of Antimicrobial Therapy for Infectious Uveitis of the Posterior Segment.

Med Hypothesis Discov Innov Ophthalmol 2018 ;7(4):140-155

UCL Institute of Ophthalmology, Moorfields Eye Hospital, London, UK.

Treatment of infectious posterior uveitis represents a therapeutic challenge for ophthalmologists. The eye is a privileged site, maintained by blood ocular barriers, which limits penetration of systemic antimicrobials into the posterior segment. In addition, topical and subconjunctival therapies are incapable of producing sufficient drug concentrations, intraocularly. Read More

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January 2018

Large drusen in long-standing retinal detachment.

Oman J Ophthalmol 2018 Sep-Dec;11(3):272-273

Department of Ocular Pathology and Uveitis, Sankara Nethralaya, Chennai, Tamil Nadu, India.

Drusen are seen as an end result of various biochemical insults to the retina and have been described in various clinical settings. We would like to report the histopathology of a case of large drusen, seen associated with chronic retinal detachment in a case of childhood trauma, where the eye was eviscerated for other reasons. Read More

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December 2018

A Retrospective Observational Study of Uveitis in a Single Center in Poland with a Review of Findings in Europe.

Med Sci Monit 2018 Dec 3;24:8734-8749. Epub 2018 Dec 3.

Department of Ophthalmology, Medical University of Warsaw, Warsaw, Poland.

BACKGROUND This study aimed to review the causes, presentation, and clinicopathological associations of uveitis in a single department of ophthalmology in Poland, and to compare the findings with previously published studies from other European countries. MATERIAL AND METHODS Review of local patient records between 2005-2015 identified patients diagnosed with uveitis. Data obtained included age, gender, imaging findings, and laboratory diagnostic findings. Read More

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December 2018
2 Reads

Focus on neuro-Behçet's disease: A review.

Neurol India 2018 Nov-Dec;66(6):1619-1628

Department of Internal Medicine and Neurology, Neurological Clinic, Trieste, Italy.

Behçet's disease (BD) is a multisystemic vasculitis disorder of almost unknown etiology, which involves small and large vessels and affects both veins and arteries. BD is characterized by recurrent oral aphthae (the main and most recurrent symptoms), genital ulcers, variable skin lesions, arthritis, uveitis, and thrombophlebitis. Other reported symptoms concern the involvement of the gastrointestinal and the central nervous system. Read More

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December 2018

Referral characteristics and wait times for uveitis consultation at academic tertiary care centres in Toronto.

Can J Ophthalmol 2018 Dec 28;53(6):639-645. Epub 2018 May 28.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ont.; Kensington Vision and Research Centre, Toronto, Ont.; St. Michael's Hospital, Toronto, Ont.. Electronic address:

Objective: To assess the characteristics of referrals to academic uveitis tertiary care centres in Toronto and identify determinants of wait time for consultation.

Design: Retrospective case series.

Methods: Consecutive new uveitis referrals received at 5 University of Toronto-affiliated uveitis tertiary care centres, between February 2016 and November 2016, were included. Read More

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December 2018

Long-term efficacy of infliximab treatment and the predictors of treatment outcomes in patients with refractory uveitis associated with Behçet's disease.

Eur J Rheumatol 2018 Mar;5(1):9-15

Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Higashi-ku, Fukuoka, Japan.

Objective: To assess the long-term efficacy and safety of infliximab (IFX) treatment for refractory uveitis associated with Behçet's disease (BD) and to identify predictors of long-term IFX therapy outcomes.

Methods: We retrospectively studied 44 consecutive BD patients with uveitis who were started on IFX therapy and analyzed the efficacy and safety of IFX and the treatment continuation rate. To determine predictors of IFX responsiveness, we analyzed the clinical characteristics of the patients who received regular maintenance therapy and those who required treatment intensification. Read More

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Syphilitic uveitis misdiagnosed as viral retinitis-a misleading history.

J Ophthalmic Inflamm Infect 2018 Dec 4;8(1):22. Epub 2018 Dec 4.

Dr Ram Manohar Lohia Hospital and Post Graduate Institute of Medical Education and Research, Baba Kharak Singh Marg, New Delhi, 110001, India.

Background: Syphilitic uveitis is an infective uveitis and a great mimicker. Misdiagnosis can lead to delay in the specific treatment resulting in deterioration of uveitis and loss of vision.

Findings: A 38-year-old unmarried female presented with pain, redness, and blurring of vision in the left eye for the last 5 days. Read More

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December 2018
2 Reads

Bartonella infections in cats and dogs including zoonotic aspects.

Parasit Vectors 2018 Dec 4;11(1):624. Epub 2018 Dec 4.

Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain.

Bartonellosis is a vector-borne zoonotic disease with worldwide distribution that can infect humans and a large number of mammals including small companion animals (cats and dogs). In recent years, an increasing number of studies from around the world have reported Bartonella infections, although publications have predominantly focused on the North American perspective. Currently, clinico-pathological data from Europe are more limited, suggesting that bartonellosis may be an infrequent or underdiagnosed infectious disease in cats and dogs. Read More

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December 2018

Regulatory Role of rno-miR-30b-5p in IL-10 and Toll-like Receptor 4 Expressions of T Lymphocytes in Experimental Autoimmune Uveitis In Vitro.

Mediators Inflamm 2018 29;2018:2574067. Epub 2018 Oct 29.

Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Eye Institute of Shandong University of Traditional Chinese Medicine, Jinan 250002, China.

Uveitis is a serious eye disease that usually damages young adult's health. MicroRNAs (miRNAs) are a class of small noncoding RNAs which regulate messenger RNA (mRNA) expression. It is predicted that rno-miR-30b-5p can regulate the expressions of interleukin-10 (IL-10) and Toll-like receptor 4 (TLR4). Read More

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October 2018

Uveitis and spondyloarthropathies.

Best Pract Res Clin Rheumatol 2017 Dec 25;31(6):846-862. Epub 2018 Oct 25.

Oxford Eye Hospital, John Radcliffe Hospital, Headley Way, Oxford, United Kingdom. Electronic address:

Uveitis is a frequently occurring extra-articular manifestation of spondyloarthropathies (SpAs), ankylosing spondylitis (AS), reactive arthritis (ReA), psoriatic arthritis (PsA) and inflammatory bowel disease (IBD), occurring in both adults and children with SpA. Uveitis occurs with varying frequency according to the SpA subtype (33% in AS, 6-9% in PsA, 25% in ReA, 13% in undifferentiated SpA and 2-5% in IBD), the presence of HLA-B27 and with increasing duration of disease. The majority of cases of uveitis in SpA are attributed to acute anterior uveitis but a minority of uveitis cases occur in the posterior segment of the eye. Read More

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December 2017

Swept-source optical coherence tomography and optical coherence tomography angiography in acquired toxoplasmic chorioretinitis: a case report.

J Med Case Rep 2018 Dec 4;12(1):358. Epub 2018 Dec 4.

Eye Unit, University Hospital Maggiore della Carità, Novara, Italy.

Purpose: To describe swept-source optical coherence tomography and optical coherence tomography angiography retinal changes in a case of acute toxoplasmic chorioretinitis both at the time of diagnosis and after healing.

Case Presentation: A 57-year-old white woman suffering from acquired toxoplasmic chorioretinitis underwent swept-source optical coherence tomography and optical coherence tomography angiography both at the time of diagnosis and after healing. In the acute phase of the disease, swept-source optical coherence tomography clearly showed retinal and choroidal involvement in the superficial retina and in the choroidal swelling. Read More

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December 2018

Evaluation of Ocular Surface and Meibomian Glands Alterations with Meibography in Patients with Inactive Behçet's Uveitis.

Curr Eye Res 2018 Nov 30. Epub 2018 Nov 30.

a Department of Ophthalmology , Ege University School of Medicine , Izmir , Turkey.

Purpose: To evaluate the ocular surface and meibography of patients with inactive Behçet's uveitis.

Methods: Twenty-five right eyes of 25 patients with inactive Behçet's uveitis (Group 1) and 25 right eyes of 25 healthy individuals (Group 2) were enrolled. Detailed eye examination along with Schirmer 1 test, tear film break-up time (t-BUT), ocular surface staining with fluorescein and Oxford scoring, ocular surface disease index (OSDI) score assessment were performed. Read More

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November 2018

[Ocular sarcoidosis as a clinical manifestation of multiorgan involvement].

Vestn Oftalmol 2018 ;134(5):32-38

Saint Petersburg branch of S. Fyodorov Eye Microsurgery Federal State Institution, 21 Yaroslava Gasheka St., Saint Petersburg, Russian Federation, 192283.

Eye lesion in sarcoidosis is often the first and only sign of a disorder, which suggests a possible systemic disease. Currently sarcoidosis is considered a multisystemic granulomatous disease that requires multidisciplinary approach.

Purpose: To study the prevalence and clinical aspects of sarcoidosis eyes based on the representative sample of patients diagnosed with extraocular nonspecific granulomatous disease. Read More

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January 2018
3 Reads

[Application of TNF-alpha inhibitors in treatment of uveitis associated with ankylosing spondylitis].

Vestn Oftalmol 2018 ;134(5. Vyp. 2):257-262

Russian Medical Academy of Postgraduate Education, Rheumatology Department, 2/1 Barrikadnaya St., Moscow, Russian Federation, 123995.

Uveitis is one of the most frequent extraskeletal manifestations of ankylosing spondylitis (AS). Despite iridocyclitis being the most prevalent form of uveitis in patients with AS, and the rareness of the involvement of posterior eye segments in the inflammatory process, the frequent exacerbation of the disease, a significant number of patients develop complications that lead to decrease of visual acuity. The review features theoretical prerequisites for application of tumor necrosis factor alpha (TNF-alpha) inhibitors: infliximab, adalimumab and etanercept. Read More

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January 2018

Commentary: Soluble CD83 Alleviates Experimental Autoimmune Uveitis by Inhibiting Filamentous Actin-Dependent Calcium Release in Dendritic Cells.

Front Immunol 2018 15;9:2659. Epub 2018 Nov 15.

Tumor Immunology Laboratory, Immunology Department, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil.

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November 2018

Choroidal imaging biomarkers.

Surv Ophthalmol 2018 Nov 26. Epub 2018 Nov 26.

Smt. Kanuri Santhamma Centre for Vitreo-Retinal Diseases, L V Prasad Eye Institute, Hyderabad-34, India. Electronic address:

The choroid is the vascular coat of the eye,and its role has been studied in multiple chorioretinal disorders. The recent advancements in choroidal imaging techniques including enhanced depth imaging optical coherence tomography (EDI-OCT), swept source (SS-OCT), enface OCT and OCT angiography have facilitated an in-depth analysis of choroid. The gradual shift from manual to automated segmentation and binarization methods have led to precise and reproducible measurements of choroidal parameters. Read More

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November 2018

IMMUNE RECOVERY UVEITIS-LIKE SYNDROME MIMICKING RECURRENT T-CELL LYMPHOMA AFTER AUTOLOGOUS BONE MARROW TRANSPLANT.

Retin Cases Brief Rep 2018 Nov 26. Epub 2018 Nov 26.

Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio.

Purpose: To report the multimodal imaging findings of immune recovery uveitis mimicking recurrent T-cell lymphoma after autologous bone marrow transplant therapy.

Methods: A 71-year-old man presented with posterior uveitis 6 weeks after chemotherapy and autologous bone marrow transplant for angioimmunoblastic T-cell lymphoma. Multimodal imaging included fluorescein angiography, fundus autofluorescence, and optical coherence tomography. Read More

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November 2018
1 Read

Treatment options for periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome in children and adults: a narrative review.

Clin Rheumatol 2018 Nov 28. Epub 2018 Nov 28.

Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease and Rheumatology-Ophthalmology Collaborative Uveitis Center, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy.

Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is the most frequent non-hereditary autoinflammatory disorder in childhood: Its onset is usually observed before 5 years, though reports regarding adulthood are increasing. The pathogenesis of the syndrome is not completely understood, but a multifactorial origin, probably based on a polygenic pattern of susceptibility, is the most probable rational pathogenetic hypothesis. Treatment of PFAPA syndrome relies on the administration of low-dose corticosteroids, which promptly abort flares but cannot prevent subsequent disease episodes over time. Read More

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November 2018
1 Read

Timing of infliximab and adalimumab initiation despite methotrexate in children with chronic non-infectious anterior uveitis.

Eye (Lond) 2018 Nov 28. Epub 2018 Nov 28.

Division of Rheumatology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati, Cincinnati, OH, USA.

Aims: Methotrexate (MTX) is standard treatment in pediatric chronic anterior uveitis (CAU). Addition of tumor necrosis factor-α inhibitors (TNFi) is often needed. We describe the timing and risk factors for TNFi use in children with CAU on MTX. Read More

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November 2018

Patterns of Uveitis at a Tertiary Referral Center in Northeastern Iran.

J Ophthalmic Vis Res 2018 Oct-Dec;13(4):522-523

Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq.

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November 2018

Sympathetic Ophthalmia: Experience from a Tertiary Care Center in Northern India.

J Ophthalmic Vis Res 2018 Oct-Dec;13(4):439-446

Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.

Purpose: To describe our clinical experience with sympathetic ophthalmia (SO) at a tertiary eye care center in north India.

Methods: In this retrospective case series, analysis of the clinical features and visual outcomes of patients diagnosed with SO between March 2012 and March 2016 were performed.

Results: Ten male and four female patients (median age, 15. Read More

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November 2018

Comparison of Retinal and Choroidal Involvement in Sarcoidosis-related Chorioretinitis Using Fluorescein and Indocyanine Green Angiography.

J Ophthalmic Vis Res 2018 Oct-Dec;13(4):426-432

Retinal and Inflammatory Eye Diseases, Centre for Ophthalmic Specialised Care, Teaching Centre Clinic Montchoisi, Lausanne, Switzerland.

Purpose: To compare the involvement of the retina with that of the choroid in ocular sarcoidosis (OS) using dual fluorescein angiography (FA)/indocyanine green angiography (ICGA).

Methods: A retrospective study of 23 patients with the diagnosis of OS was performed. Angiographic signs were quantified following the established FA/ICGA scoring system for uveitis. Read More

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November 2018
2 Reads

An unusual case of post-cochlear implant performance degradation in a patient with suspected Cogan's syndrome.

Cochlear Implants Int 2018 Nov 24:1-6. Epub 2018 Nov 24.

d KK Children's & Women's Hospital , Singapore.

Cogan's Syndrome is an autoimmune disorder that can affect the ear, eye and other organs. Although rare, Cogan's Syndrome is particularly relevant to the cochlear implant surgeon because the resulting hearing loss is often bilateral and the majority of cases progresses to profound levels where cochlear implantation may be indicated. There are many issues relating to this condition that concern the cochlear implant surgeon. Read More

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November 2018
3 Reads

The role of pars plana vitrectomy in the management of fungal endogenous endophthalmitis.

Eur J Ophthalmol 2018 Nov 26:1120672118815105. Epub 2018 Nov 26.

Department of Ophthalmology, School of Medicine, Marmara University, Istanbul, Turkey.

Purpose:: To identify the causative microorganism of fungal endogenous endophthalmitis in our tertiary referral uveitis center and review the therapeutic role of pars plana vitrectomy in patients with fungal endogenous endophthalmitis.

Methods:: Seven eyes of six cases were identified as fungal endogenous endophthalmitis through positive cultures of ocular fluids and clinical presentations. The final anatomical and functional results were evaluated. Read More

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November 2018
2 Reads

Emerging infectious uveitis: Chikungunya, Dengue, Zika, Ebola.

Clin Exp Ophthalmol 2018 Nov 25. Epub 2018 Nov 25.

Flinders University College of Medicine & Public Health, Adelaide, Australia.

Recently recognised forms of uveitis include intraocular inflammations that occur during or following one of several emerging infectious diseases: chikungunya fever, dengue, Zika virus disease and Ebola virus disease. Anterior, intermediate, posterior and pan- uveitis have been described in individuals infected with chikungunya virus. Persons who contract dengue or Zika viruses also may develop different types of uveitis in the course of the infection: maculopathy is a common manifestation of dengue eye disease, and Zika eye disease may cause hypertensive anterior uveitis or mimic a white dot syndrome. Read More

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November 2018
2 Reads

New data in causes of autoinflammatory diseases.

Joint Bone Spine 2018 Nov 21. Epub 2018 Nov 21.

Centre national de référence des maladies auto-inflammatoires et de l'amylose inflammatoire (CEREMAIA), 94270 Le Kremlin-Bicêtre, France; Cellules souches, plasticité cellulaire, médecine régénératrice et immunothérapies, INSERM, Université de Montpellier, 34090 Montpellier, France; Département de génétique médicale, maladies rares et médecine personnalisée, CHU Montpellier, 34295 Montpellier, France.

The spectrum of factors known to mediate autoinflammation has broadened recently to include not only interleukin-1 (IL-1) and interferon, but also abnormalities that impair NF-κB pathway negative regulation. The NF-κB pathway is activated upon contact of a ligand with tumor necrosis factor receptor 1 (TNFR1) and plays a pivotal role in triggering the inflammatory process by producing major cytokines such as IL-1, IL-6, and TNF. Negative regulation of the NF-κB pathway, which is essential to stop the inflammatory process, depends on the level of ubiquitination of the proteins associated with TNFR1 and of other intermediate compounds. Read More

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November 2018
2 Reads

Nanofluidic microsystem for sustained intraocular delivery of therapeutics.

Nanomedicine 2018 Nov 20. Epub 2018 Nov 20.

Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, USA; Department of Surgery, Houston Methodist Hospital, Houston, TX, USA; Department of Radiation Oncology, Houston Methodist Hospital, Houston, TX, USA. Electronic address:

Globally, 145.2 million people suffer from moderate to severe vision impairment or blindness due to preventable or treatable causes. However, patient adherence to topical or intravitreal treatment is a leading cause of poor outcomes. Read More

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November 2018
3 Reads

The development of multiple ocular complications in a patient with Parry-Romberg syndrome.

Clin Exp Optom 2018 Nov 22. Epub 2018 Nov 22.

School of Optometry, University of Alabama at Birmingham and Birmingham Veterans Affairs Medical Center, Birmingham, Alabama, USA.

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November 2018
2 Reads

Pharmacokinetics of topically applied tacrolimus dissolved in Marinosolv, a novel aqueous eye drop formulation.

Eur J Pharm Biopharm 2018 Nov 19. Epub 2018 Nov 19.

Clinical Department for Farm Animals and Herd Management, University of Veterinary Medicine Vienna, Veterinärplatz 1, Vienna, Austria.

Corticosteroids and macrolide immunomodulators such as tacrolimus are effective drugs for the topical treatment of inflammatory eye diseases like allergic conjunctivitis or dry eye. However, tacrolimus is practically insoluble in aqueous solutions and is therefore currently formulated as dispersion. This leads to low bioavailability. Read More

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November 2018
4 Reads

Sympathetic ophthalmia in fellow eye after vitrectomy for massive subretinal hemorrhage secondary to polypoidal choroidal vasculopathy.

Int Med Case Rep J 2018 30;11:293-296. Epub 2018 Oct 30.

Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan,

We experienced a case of sympathetic ophthalmia in a fellow eye after vitrectomy for subretinal hemorrhage related to polypoidal choroidal vasculopathy. A 60-year-old male consulted us for polypoidal choroidal vasculopathy with subretinal hemorrhage in his left eye. The recurrence of massive subretinal hemorrhage refractory to repeated pars plana vitrectomies leads to phthisis bulbi. Read More

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October 2018
3 Reads

Adult-onset Buphthalmos in Down Syndrome.

J Glaucoma 2018 Nov 19. Epub 2018 Nov 19.

Department of Ophthalmology, School of Medicine of Ribeirão Preto, University of São Paulo, Avenida Bandeirantes, Ribeirão Preto, São Paulo, Brazil.

Purpose: To report a peculiar case of adult-onset buphthalmos.

Methods: Review of the medical record of a 24-year-old patient with Down syndrome who developed buphthalmos in the left eye after corneal transplantation for keratoconus.

Results: In the next 2 years after surgery, the operated eye evolved with chronic anterior uveitis that led to progressive peripheral synechiae, oscillating intraocular pressure, cataract, graft failure, and buphthalmos. Read More

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November 2018
1 Read

Clinical presentations, management outcomes, and diagnostic dilemma in Kocuria endophthalmitis.

J Ophthalmic Inflamm Infect 2018 Nov 20;8(1):21. Epub 2018 Nov 20.

Smt. Kanuri Santhamma Center for Vitreoretinal Diseases, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Hyderabad, Telangana, 500034, India.

Aim: To describe the clinical presentations and management outcomes of Kocuria endophthalmitis and discuss diagnostic dilemmas DESIGN: Retrospective interventional comparative case series INTERVENTION: Eight unilateral cases with culture-proven Kocuria endophthalmitis from January 2013 to December 2017 underwent vitrectomy/vitreous biopsy and intravitreal antibiotic with or without additional procedures. The undiluted vitreous was subjected to microbiologic evaluation.

Main Outcome Measures: The mean age at presentation, etiology, number of interventions, interval between inciting event and presentation, type of intravitreal antibiotic used, and anatomic and functional outcomes were reported. Read More

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November 2018
1 Read

Uveitis: contrasting the approaches in Japan and the United States.

Jpn J Ophthalmol 2018 Nov 20. Epub 2018 Nov 20.

Casey Eye Institute, Oregon Health and Sciences University, 3375 SW, Terwilliger Blvd, Portland, OR, 97239, USA.

Purpose: To compare the approaches to uveitis in Japan and the United States.

Methods: This report is based on the author's personal experience, conversations with Japanese colleagues, and a literature search using the database of the US National Library of Medicine.

Results: The frequencies of specific forms of uveitis vary between the two countries. Read More

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November 2018
1 Read

Targeting Interleukin-23 in the Treatment of Noninfectious Uveitis.

Ophthalmology 2018 Dec 4;125(12):1977-1983. Epub 2018 Jul 4.

Casey Eye Institute, Oregon Health & Science University, Retinal and Vitreous Diseases/Surgery, Ocular Inflammation and Immunology, Portland, Oregon.

The interleukin (IL)-23/IL-17 axis plays a central role in the pathogenesis of immune-mediated diseases such as psoriasis, psoriatic arthritis, Crohn's disease, and uveitis. Therefore, targeting the IL-23/IL-17 axis has become the focus of multiple clinical trials for drug development in patients with autoimmune diseases. We briefly describe the biology of the IL-23/IL-17 axis and its relevance to the pathogenesis of experimental and clinical uveitis, and review the monoclonal antibody therapies targeting this pathway. Read More

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December 2018
1 Read

New insight into the diagnostic cut-off value of serum anti-Toxocara IgG for ocular toxocariasis in uveitis patients.

J Helminthol 2018 Nov 20:1-6. Epub 2018 Nov 20.

Department of Ophthalmology,Faculty of Medicine,Zagazig University,Egypt.

Uveitis is one of the commonest causes of vision loss worldwide and its exact etiology is still not clarified in most patients. The current study is a trial to assess the efficacy of serum anti-Toxocara immunoglobulin G (IgG) by enzyme-linked immunosorbent assay (ELISA) as a diagnostic tool for ocular toxocariasis (OT) and to detect OT prevalence and the associated ocular manifestations in sera of patients with uveitis. One hundred and twelve patients (62 females and 50 males) with uveitis were diagnosed by ophthalmologists, radiologists and rheumatologists according to ocular manifestations, laboratory and radiological investigations. Read More

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November 2018
1 Read

Tubulointerstitial Nephritis.

Pediatr Clin North Am 2019 Feb;66(1):111-119

Department of Pediatrics, Division of Nephrology, Johns Hopkins University School of Medicine, 200 North Wolfe Street, Room 3055, Baltimore, MD 21287, USA.

Tubulointerstitial nephritis (TIN) is a cause of acute kidney injury in children characterized histologically by an inflammatory cell infiltrate in the kidney interstitium. The most common causes of TIN in children include medications, infections, inflammatory disorders, and genetic conditions. TIN typically presents with nonoliguric acute kidney injury and may be associated with systemic symptoms, including fever, rash, and eosinophilia. Read More

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February 2019
8 Reads

Progressive, subretinal fibrosis mimicking retinal necrosis with poor visual prognosis in sympathetic ophthalmia: A rare finding.

Indian J Ophthalmol 2018 Dec;66(12):1877-1879

Department of Uveitis and Ocular Inflammation, Vittala International Institute of Ophthalmology and Prabha Eye Clinic and Research Centre, Bengaluru, Karnataka, India.

We report a rare finding of progressive subretinal fibrosis mimicking retinal necrosis in 2 cases of sympathetic ophthalmia. Histopathology of the inciting eye and vitreous biopsy of the sympathizing eye ruled out infections and masquerades. Progression of inflammation and rapid deterioration of vision inspite of maximum immunosuppression are key findings in this variant of sympathetic ophthalmia. Read More

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December 2018
3 Reads

Commentary: Post fever retinitis and vasculitis: A morphological conundrum.

Authors:
Bhavik Panchal

Indian J Ophthalmol 2018 Dec;66(12):1844

Department of Vitreoretina and Uveitis Services, L V Prasad Eye Institute, Visakhapatnam, Andhra Pradesh, India.

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December 2018
1 Read

Sarcoidosis.

J Fr Ophtalmol 2018 Nov 15. Epub 2018 Nov 15.

Department of Ophthalmology, hôpital Cochin, Assistance publique-Hôpitaux de Paris, université Paris Descartes, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France.

Sarcoidosis is a systemic granulomatosis characterized by the formation of epithelioid and giant cell granulomas without caseous necrosis. To make the diagnosis, it is necessary to prove systemic granulomatosis involving at least two organs; but in practice, a combination of clinical, paraclinical and histologic findings is used. It affects predominantly women with a bimodal age distribution: 25-29 years and 65-69 years. Read More

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November 2018
1 Read

Lymphopaenia as a predictor of sarcoidosis in patients with a first episode of uveitis.

Br J Ophthalmol 2018 Nov 15. Epub 2018 Nov 15.

Department of Internal Medicine, Section Clinical Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Background/aims: The diagnostic properties of conventional diagnostic tests (ACE and chest radiography) for sarcoidosis-associated uveitis are not ideal. The diagnostic value of lymphopaenia for sarcoidosis-associated uveitis is investigated.

Methods: A retrospective study of 191 consecutive patients with a first uveitis episode visiting the ophthalmology department (Erasmus Medical Center, Rotterdam, The Netherlands). Read More

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November 2018
1 Read

[Clinical features of glucocorticoid eye drops induced ocular hypertension in pediatric and adult uveitic eyes].

Zhonghua Yan Ke Za Zhi 2018 Nov;54(11):839-842

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

To investigate the clinical features of glucocorticoid eye drops induced ocular hypertension in pediatric and adult uveitic eyes. Retrospective survey of consecutive uveitic patients attending referral service at Peking Union Medical College Hospital from March 2013 to August 2017. Incidences of glucocorticoid eye drops induced ocular hypertension were compared between the pediatric and adult uveitic groups. Read More

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November 2018
4 Reads

[Effect of 2% ganciclovir eye drops on cytomegalovirus positive Posner-Schlossman syndrome].

Zhonghua Yan Ke Za Zhi 2018 Nov;54(11):833-838

Department of Ophthalmology, Eye & ENT Hospital of Fudan University, NHC Key Laboratory of Myopia(Fudan University); Laboratory of Myopia, Chinese Academy of Medical Science, Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai 200031, China.

To observe the effect of 2% ganciclovir eye drops on Posner-Schlossman syndrome (PSS) patients with positive cytomegalovirus (CMV) in aqueous humor. Prospective study. The cases clinically diagnosed as PSS with positive CMV were enrolled from August 2017 to January 2018 at Department of Ophthalmology, Eye & ENT Hospital of Fudan University. Read More

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November 2018
5 Reads

High-Dimensional Profiling Reveals Heterogeneity of the Th17 Subset and Its Association With Systemic Immunomodulatory Treatment in Non-infectious Uveitis.

Front Immunol 2018 31;9:2519. Epub 2018 Oct 31.

Ophthalmo-Immunology Unit, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.

Non-infectious uveitis (NIU) is a severe intra ocular inflammation, which frequently requires prompt systemic immunosuppressive therapy (IMT) to halt the development of vision-threatening complications. IMT is considered when NIU cannot be treated with corticosteroids alone, which is unpredictable in advance. Previous studies have linked blood cell subsets to glucocorticoid sensitivity, which suggests that the composition of blood leukocytes may early identify patients that will require IMT. Read More

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October 2018
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How ERAP1 and ERAP2 Shape the Peptidomes of Disease-Associated MHC-I Proteins.

Front Immunol 2018 30;9:2463. Epub 2018 Oct 30.

Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain.

Four inflammatory diseases are strongly associated with Major Histocompatibility Complex class I (MHC-I) molecules: birdshot chorioretinopathy (HLA-A29:02), ankylosing spondylitis (HLA-B27), Behçet's disease (HLA-B51), and psoriasis (HLA-C06:02). The endoplasmic reticulum aminopeptidases (ERAP) 1 and 2 are also risk factors for these diseases. Since both enzymes are involved in the final processing steps of MHC-I ligands it is reasonable to assume that MHC-I-bound peptides play a significant pathogenetic role. Read More

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October 2018
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