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J Surg Case Rep 2020 Nov 30;2020(11):rjaa468. Epub 2020 Nov 30.

Department of Ophthalmology, Loma Linda University, Loma Linda, CA, USA.

Behçet's disease (BD) is a multisystemic, immune-mediated occlusive vasculitis of unknown etiology with a chronic, relapsing remitting course. Ocular involvement is characterized by recurrent nongranulomatous uveitis with necrotizing obliterative vasculitis affecting both the anterior and posterior segments of the eye and often leads to blindness. We describe successful surgical management of a rare case of combined rhegmatogenous retinal detachment (RRD) and tractional retinal detachment (TRD) in a patient with Behçet's disease. Read More

JAMA Ophthalmol 2021 01;139(1):95-102

Department of Ophthalmology, Centre Hospitalier Universitaire, Guadeloupe, French West Indies.

Importance: Acute anterior uveitis has been reported to be associated with Zika virus (ZIKV) infection in case reports and retrospective studies based on systemic clinical signs of ZIKV and positive serologic tests.

Objective: To describe the ophthalmic findings associated with systemic ZIKV infection during the 2016 ZIKV outbreak in Guadeloupe in the French West Indies.

Design, Setting, And Participants: This cohort study assessed adult patients with red eye and virologic or serologic confirmation of acute ZIKV infection who were admitted to the Pointe-à-Pitre University Hospital from January 1, 2016, to January 1, 2017, for a systematic ophthalmologic examination. Read More

Arch Soc Esp Oftalmol 2021 Feb 4;96(2):89-92. Epub 2020 Nov 4.

Department of Ophthalmology, IRCCS Ospedale San Raffaele, University Vita-Salute San Raffaele, Milán, Italia.

Clinical Case: A 46-year-old caucasian male with a history of chronic conjunctival hyperemia, presented at our clinic 5 years after he underwent the surgical procedure of cosmetic eye whitening. On examination we observed pyogenic granuloma in the right eye; besides acute nongranulomatous anterior uveitis and necrotizing scleritis in both eyes.

Result: Complete clinical evaluation and full work-up exclusion of systemic diseases was done. Read More

Arch Rheumatol 2020 Mar 6;35(1):142-145. Epub 2019 Nov 6.

Department of Ophthalmology, Medical Health Sciences University, Kartal Dr. Lütfi Kırdar Training and Research Hospital, Istanbul, Turkey.

Relapsing polychondritis (RP) is a rare multisystemic disease. It affects cartilage and proteoglycan-rich structures. Ocular findings are the most frequent systemic involvement of the disease. Read More

Taiwan J Ophthalmol 2020 Jan-Mar;10(1):66-70. Epub 2020 Mar 4.

Department of Pathology, Hacettepe University, Ankara, Turkey.

The tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disorder that is probably underdiagnosed in clinical practice. Ocular involvement in TINU syndrome not only presents with the nongranulomatous anterior uveitis in 80% of patients but also manifests as intermediate, posterior, or panuveitis. This case report mentions an adult male patient who presented with granulomatous iridocyclitis with panuveitis and mild renal insufficiency. Read More

Turk J Ophthalmol 2019 09;49(4):188-193

Consultant Ophthalmologist, Puducherry, India (Past Affiliation: ESIC Medical College and PGIMSR, K.K. Nagar, Chennai)

Objectives: Ocular tuberculosis is an extrapulmonary tuberculous infection and has varying manifestations which pose a huge challenge to diagnosis and treatment. The purpose of this study is to describe the various clinical manifestations of ocular inflammations due to tuberculosis and to assess the response to treatment following antituberculous therapy (ATT) and corticosteroids in these patients.

Materials And Methods: We performed a retrospective analysis of 29 patients with presumed ocular tuberculosis who were started on ATT and completed follow-up of at least 6 months after ATT was initiated. Read More

J Bras Nefrol 2018 Jul-Sep;40(3):296-300. Epub 2018 Jun 18.

Unidade de Nefrologia e Transplantação Renal, Serviço de Pediatria Médica, Departamento de Pediatria, Hospital de Santa Maria, Centro Académico de Medicina, Universidade de Lisboa, Lisboa, Portugal.

Tubulointerstitial nephritis and uveitis syndrome is a rare and probably underdiagnosed condition. Renal and ocular manifestations may not occur simultaneously, making the diagnosis more difficult. Nephritis may be asymptomatic; therefore, renal function evaluation is essential for diagnosis. Read More

Am J Ophthalmol Case Rep 2018 Jun 8;10:117-118. Epub 2018 Feb 8.

F.I. Proctor Foundation, University of California, San Francisco, United States.

Purpose: To report on a case of uveitis and scleritis resulting as an immune-mediated side effect of cancer immunotherapy with nivolumab and cabiralizumab.

Observations: Bilateral anterior nongranulomatous anterior uveitis and bilateral diffuse anterior and posterior scleritis occurred following the use of combination cancer immunotherapy. The uveitis and scleritis resolved following temporary discontinuation of nivolumab and cabiralizumab as well as systemic prednisone. Read More

Retin Cases Brief Rep 2020 ;14(3):228-231

Department of Ophthalmology, CHU Saint-Pierre, Université Libre de Bruxelles, Brussels, Belgium.

Purpose: To present a case of frosted branch periphlebitis in a young Armenian patient with familial Mediterranean fever.

Methods: Case report.

Results: A 37-year-old man presented with a unilateral decreased visual acuity and floaters for 4 days on the left eye (LE). Read More

Int Ophthalmol 2018 Dec 21;38(6):2487-2493. Epub 2017 Nov 21.

Department of Uvea, Medical Research Foundation, Sankara Nethralaya, Chennai, 600006, India.

Purpose: To describe clinical manifestations, management and visual outcome in postsurgical sympathetic ophthalmia (SO).

Methods: Retrospective study.

Results: Mean age of the patients was 41. Read More

Invest Ophthalmol Vis Sci 2017 09;58(11):4778-4783

Karl Landsteiner Institute for Retinal Research and Imaging, Department of Ophthalmology, Rudolf Foundation Hospital, Vienna, Austria.

Purpose: To analyze retinal thickness (RT) and choroidal thickness (ChT) changes in patients with unilateral nongranulomatous acute anterior uveitis (AAU) using three-dimensional (3D) 1060-nm optical coherence tomography (OCT).

Methods: Retinal and choroidal thickness maps were statistically analyzed for 24 patients with newly diagnosed unilateral AAU before therapy. A total of 17 patients were followed until resolution of inflammatory activity (twice in the first week, then weekly). Read More

Surv Ophthalmol 2017 May - Jun;62(3):277-285. Epub 2016 Dec 22.

Princess Alexandra Eye Pavilion, Edinburgh, United Kingdom.

Posner-Schlossman syndrome, or glaucomatocyclitic crisis, is a unilateral ocular condition characterized by recurrent attacks of nongranulomatous anterior uveitis and raised intraocular pressure that can result in chronic secondary glaucoma. This relatively rare disease is most likely the result of recurrent cytomegalovirus infection and affects predominantly middle-aged males. Diagnosis is largely clinical, with aqueous and blood sampling aiding the identification of any underlying infectious cause. Read More

Retin Cases Brief Rep 2017 Fall;11(4):348-351

*Dartmouth College, Hanover, New Hampshire; and †Michigan State University, Grand Rapids, Michigan.

Purpose: To describe the development of uveitis and retinal vasculitis in association with pembrolizumab treatment for metastatic uveal melanoma.

Methods: A case report and a brief review of the literature are presented. Information collected and reported include the patient's clinical course, physical examination findings, fluorescein angiogram images, retinal photographs, and her response to treatment. Read More

Optom Vis Sci 2016 06;93(6):647-51

*OD, FAAO †OD New Mexico VA Health Care System, Albuquerque, New Mexico.

Purpose: The incidence of syphilis appears to be increasing in recent years. Although any structure of the eye can be involved in syphilis, isolated unilateral anterior uveitis as an initial sign of the disease is rare. We report a case of ocular syphilis presenting as a mild unilateral, nongranulomatous, anterior uveitis in an otherwise asymptomatic patient. Read More

Ophthalmologica 2016 5;235(1):18-25. Epub 2015 Nov 5.

Department of Ophthalmology at National Defense Medical College, Saitama, Japan.

Purpose: The aim of this study was to compare the outcomes of vitrectomy in granulomatous uveitis and nongranulomatous uveitis insufficiently managed by immunosuppressive therapy.

Methods: Thirty-eight eyes with granulomatous uveitis and 17 eyes with nongranulomatous uveitis that underwent vitrectomy for ocular complications between July 2006 and August 2012 were reviewed retrospectively. Visual acuity and ocular inflammation scores before and 6 months after surgery were compared. Read More

Optom Vis Sci 2015 May;92(5):e97-e105

*OD, DO, MS, FAAO †BA Department of Ophthalmology, Mayo Clinic Health System, Albert Lea, Minnesota (LS, Jr.); and Pacific University College of Optometry, Forest Grove, Oregon (LG).

Purpose: To present a case of neovascular age-related macular degeneration treated with aflibercept intravitreal injections after bilateral bevacizumab injections, administered on separate dates, resulted in bilateral iritis.

Case Report: A 73-year-old woman with a previous history of two episodes of nongranulomatous iritis in her right eye that was believed to be associated with her systemic diagnosis of rheumatoid arthritis was treated with intravitreal bevacizumab injections for bilaterally occurring neovascular age-related macular degeneration. Initial bevacizumab injections in each eye administered sequentially over a week's time resulted in immediate-onset nongranulomatous iritis in each eye. Read More

J Ophthalmic Inflamm Infect 2015 13;5. Epub 2015 Feb 13.

Department of Pediatric Rheumatology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Background: Tubulointerstitial nephritis and uveitis [TINU] syndrome is a rare disorder that may also be underdiagnosed. Patients with TINU syndrome typically present with an acute bilateral nongranulomatous anterior uveitis following symptoms of systemic illness.

Findings: We report the case of a 15-year-old girl who presented with acute granulomatous iridocyclitis and was diagnosed with TINU syndrome based on renal biopsy findings. Read More

Clin Ophthalmol 2014 26;8:2383-9. Epub 2014 Nov 26.

Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Purpose: To investigate the characteristics of uveitic glaucoma (UG) and evaluate surgical treatments.

Methods: This study examined a retrospective, nonrandomized comparative interventional case series of 105 UG patients (141 eyes) followed between April 1, 2001 and July 30, 2014 at the outpatient clinic of Tohoku University Hospital. The study group included 47 patients (47 eyes) who underwent glaucoma surgery: trabeculectomy, trabeculotomy, and trabectome surgery. Read More

Ocul Immunol Inflamm 2015 Aug 24;23(4):311-319. Epub 2014 Jul 24.

a Department of Ophthalmology , College of Medicine, King Saud University , Riyadh , Saudi Arabia.

Purpose: To investigate the referral patterns and diagnosis of uveitis in a university-based tertiary referral center in Riyadh, Saudi Arabia.

Methods: We retrospectively reviewed the medical records of 642 patients (1220 eyes).

Results: There were 295 (46%) males and 347 (54%) female patients, with a mean age of 36. Read More

Am J Ophthalmol 2014 Sep 27;158(3):637-43.e1. Epub 2014 May 27.

Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.

Purpose: To describe the clinical presentation of uveitis with coincident onset of raised and indurated tattooed skin.

Design: Case series.

Methods: Seven consecutive patients were evaluated at a tertiary ophthalmologic facility with coincident uveitis and cutaneous tattoo induration over an 18-month period. Read More

Ocul Immunol Inflamm 2014 Jun 24;22(3):236-8. Epub 2014 Feb 24.

Department of Medicine, Division of General Internal Medicine, The Johns Hopkins University School of Medicine , Baltimore, Maryland , USA .

Purpose: To describe a case of Rosai-Dorfman-associated sclerouveitis in an HIV-infected patient.

Design: Case report.

Methods: A 49-year-old man with HIV had bilateral eye pain, redness, photophobia, and multiple systemic complaints. Read More

Saudi J Ophthalmol 2013 Oct 19;27(4):295-8. Epub 2013 Jun 19.

Anterior Segment and Uveitis Division, Ophthalmology Department, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia.

A 34-year-old female with Usher syndrome, but no family history of similar illness, presented with complaints of vision reduction, redness, and photophobia. Biomicroscopic examination showed mildly injected conjunctivae bilateral, small, round keratic precipitates; bilateral +2 cells with no flare reaction in the anterior chamber; and bilateral posterior subcapsular cataracts. No associated posterior synechiae, angle neovascularization, or iris changes were detected; normal intraocular pressures were obtained. Read More

Dig Dis 2013 6;31(2):229-32. Epub 2013 Sep 6.

Department of Ophthalmology, Miguel Servet University Hospital, Instituto de Investigación Sanitaria de Aragón IIS-A, Zaragoza, Spain.

Extraintestinal manifestations are common in inflammatory bowel disease (IBD), being reported in over 25% of patients. Ocular complications of IBD occur in around 10% of cases, but may precede systemic symptoms and are usually nonspecific. Complications of therapy, such as cataracts or glaucoma from steroid use or keratoconjunctivitis sicca related to 5-aminosalicylic acid medications, may also involve the eyes. Read More

Ocul Immunol Inflamm 2013 Dec 19;21(6):478-85. Epub 2013 Aug 19.

John A. Moran Eye Center, Salt Lake City , Utah , USA .

Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease and the most prevalent systemic disorder in children with uveitis. The risk of developing uveitis is the greatest among patients with oligoarticular onset of disease. Clinical features of JIA-associated uveitis (JIAU) are nongranulomatous inflammation, anterior in location, insidious at onset, chronic course, and frequently asymptomatic in the absence of ocular structural complications. Read More

Ocul Immunol Inflamm 2013 Oct 3;21(5):337-50. Epub 2013 Jun 3.

Department of Ophthalmology, Istanbul Faculty of Medicine, Istanbul University , Istanbul , Turkey .

The diagnosis of Behçet disease is clinical and based on the presence of characteristic ocular and systemic inflammatory manifestations. Patients may present with anterior, posterior, or panuveitis in one or both eyes. The differential diagnosis includes a variety of infectious and noninfectious causes of acute nongranulomatous anterior uveitis, intermediate uveitis, occlusive retinal vasculitis, focal or multifocal retinitis, and necrotizing retinitis. Read More

J Ophthalmic Inflamm Infect 2013 Feb 11;3(1):33. Epub 2013 Feb 11.

Hospital de Olhos Santa Luzia, Estrada do Encanamento 909, CEP 52070-000, Recife-Pernambuco, Brazil.

Background: This paper reports the case of a pleomorphic manifestation of syphilis, a reemerging sexually transmitted disease.

Findings: A 51-year-old male presented with bilateral nongranulomatous anterior uveitis associated with an isolated syphilitic chancre of the tongue that was successfully treated with parenteral benzathine penicillin.

Conclusion: Syphilis has the potential to lead to any type of intraocular inflammation. Read More

J Ophthalmic Inflamm Infect 2013 Feb 11;3(1):37. Epub 2013 Feb 11.

Laboratory of Immunology, National Eye Institute, National Institutes of Health, 10 Center Dr, 10/10N112, Bethesda, MD, 20892, USA.

Background: The purpose of this study was to report the case of a patient with bilateral panuveitis who was found to have a rarely reported intraocular fungus, Aspergillus conicus. A 40-year-old man presented with gradual vision loss in both eyes. He had bilateral anterior uveitis, granulomatous vitritis with a preretinal granuloma in the right eye, and nongranulomatous vitritis with two quadrants of chorioretinal scarring in the left. Read More

Korean J Ophthalmol 2013 Feb 18;27(1):58-60. Epub 2012 Dec 18.

Department of Ophthalmology, Kyungpook National University School of Medicine, Daegu, Korea.

A 32-year-old male who had infective endocarditis complained of photophobia and blurred vision in both eyes. Biomicroscopic examination and fundus examination revealed anterior chamber reaction, vitritis, optic disc swelling, and Roth spots. He was diagnosed with bilateral nongranulomatous uveitis and treated with topical steroid eye drops and posterior sub-Tenon injection of triamcinolone. Read More

Ocul Immunol Inflamm 2013 ;21(1):44-6

Aim: To report 2 cases of idiopathic anterior uveitis with coexistent myasthenia gravis.

Materials And Methods: Retrospective case reports.

Results: A 60-year-old male and a 40-year-old male presented with chronic nongranulomatous anterior uveitis of unknown etiology. Read More