456 results match your criteria Uveitis Anterior Granulomatous


Bilateral Acute Anterior Uveitis and Corneal Punctate Epitheliopathy in Children Diagnosed with Multisystem Inflammatory Syndrome Secondary to COVID-19.

Ocul Immunol Inflamm 2021 Apr 15:1-5. Epub 2021 Apr 15.

Department of Pediatric Infectious Diseases, Health Sciences University, Dr. Sami Ulus Education and Research Hospital, Ankara, Turkey.

: To report bilateral anterior uveitis and corneal punctate epitheliopathy in children with multisystem inflammatory syndrome (MIS-C) secondary to coronavirus disease (COVID-19).: Five patients who were positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies and diagnosed with MIS-C were evaluated. Ophthalmologic examinations were performed in order to reveal ocular findings in MIS-C disease. Read More

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Epidemiology of Childhood Uveitis in a Tertiary Care Center: A 20-Year Study.

Klin Monbl Augenheilkd 2021 Apr 14;238(4):469-473. Epub 2021 Apr 14.

Jules-Gonin Eye Hospital, Department of Ophthalmology, University of Lausanne, Lausanne, Switzerland.

Purpose: To investigate demographics and causes of pediatric uveitis in a Swiss tertiary reference center over a 20-year period.

Materials And Methods: Retrospective cohort study on patients with uveitis aged less than 16 years seen at Jules-Gonin Eye Hospital between 1 January 2000 and 31 December 2019.

Results: Out of 2846 patients with uveitis seen in the Jules-Gonin Eye Hospital Ocular Immune-Infectiology Department, 317 (11. Read More

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Anterior Segment-Optical Coherence Tomography features in Blau syndrome.

Photodiagnosis Photodyn Ther 2021 Apr 1;34:102278. Epub 2021 Apr 1.

Pediatric Rheumatology Unit, Department of Mother and Child, Federico II University, Naples, Italy.

Blau syndrome (BS) is a rare granulomatous auto-inflammatory disease, characterized by the classic clinical triad of joints, skin and ocular involvements. Ocular manifestation usually consists in a bilateral insidious chronic anterior uveitis with a potential evolution to panuveitis. We describe the case of two siblings, an 8-years old female and a 5-years old male, with a diagnosis of BS, evaluated by Anterior Segment-Optical Coherence Tomography (AS-OCT). Read More

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Bilateral acute retinal necrosis during treatment with alemtuzumab for multiple sclerosis.

Eur J Ophthalmol 2021 Mar 31:11206721211006576. Epub 2021 Mar 31.

Department of Ophthalmology, Scientific Institute San Raffaele, University Vita-Salute San Raffaele, Milan, Italy.

Introduction: Alemtuzumab is a humanized monoclonal antibody used as a treatment of multiple sclerosis (MS) and chronic lymphocytic leukemia. It decreases T cell count leading to significant immunosuppression, with increased risk of systemic and ocular infections. Herein, we report a unique case of bilateral acute retinal necrosis (ARN) caused by varicella-zoster virus (VZV) in a patient affected by MS under treatment with alemtuzumab. Read More

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Systemic associations of sarcoid uveitis: correlation with uveitis phenotype and ethnicity.

Am J Ophthalmol 2021 Mar 15. Epub 2021 Mar 15.

Royal Victoria Eye and Ear, Melbourne, Australia; Centre for Eye Research Australia, University of Melbourne, Melbourne, Australia.

Purpose: To examine systemic associations of sarcoid uveitis and association with uveitis clinical phenotype and ethnicity.

Design: Retrospective cross-sectional study.

Subjects: 362 subjects with definite or presumed sarcoid uveitis from Moorfields Eye Hospital, Royal Victorian Eye and Ear and Auckland District Health Board. Read More

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Granulomatous Features in Juvenile Idiopathic Arthritis-Associated Uveitis is Not a Rare Occurrence.

Clin Ophthalmol 2021 8;15:1055-1059. Epub 2021 Mar 8.

Retinal and Inflammatory Eye Diseases, Centre for Ophthalmic Specialized Care (COS), Clinic Montchoisi Teaching Centre, Lausanne, Switzerland.

Background: Juvenile idiopathic arthritis (JIA)-associated uveitis is the most common form of intraocular inflammation with systemic involvement in childhood. Textbooks tend to describe it as non-granulomatous anterior uveitis. Here, we report the percentage of granulomatous features in JIA-related uveitis among patients at a uveitis referral center. Read More

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A novel mutation in early-onset sarcoidosis/Blau syndrome: an association with Propionibacterium acnes.

Pediatr Rheumatol Online J 2021 Feb 18;19(1):18. Epub 2021 Feb 18.

Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, 755-8505, Ube, Yamaguchi, Japan.

Background: Early-onset sarcoidosis (EOS) and Blau syndrome (BS) are systemic inflammatory granulomatous diseases without visible pulmonary involvement, and are distinguishable from their sporadic and familial forms. The diseases are characterized by a triad of skin rashes, symmetrical polyarthritis, and recurrent uveitis. The most common morbidity is ocular involvement, which is usually refractory to conventional treatment. Read More

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February 2021

Granulomatous uveitis and choroidal detachment in a patient after topical treatment with Bimatoprost: A case report.

Eur J Ophthalmol 2021 Jan 28:1120672121990573. Epub 2021 Jan 28.

Ophthalmology Department, University of Bari, Bari, Italy.

Background: Bimatoprost 0.03% is an intraocular pressure (IOP) lowering prostaglandin analog with different adverse side effects such as potential ocular inflammatory effect and ocular hyperemia.

Case Presentation: We report a case of 80-year-old woman diagnosed with bilateral glaucomatous uveitis, and choroidal detachment in the left eye after topical bimatoprost administration. Read More

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January 2021

[Sarcoid granuloma of the iris (clinical cases and state of the problem)].

Vestn Oftalmol 2020 ;136(6. Vyp. 2):219-226

Chelyabinsk Regional Clinical Tuberculosis Dispensary, Chelyabinsk, Russia.

Granulomatous lesion of the iris has varying etiology, but in the differential diagnostic it should often be considered by sarcoidosis and tuberculosis damage.

Purpose: To describe a clinical case of sarcoid lesion of the iris and provide an analysis of literature devoted to this problem in the context of its polyetiology.

Material And Methods: The article describes one case of sarcoid granuloma of the iris in a young patient with a relapsing course of the disease. Read More

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December 2020

Ocular porcupine quilling in dogs: Gross, clinical and histopathologic findings in 17 cases (1986-2018).

Vet Ophthalmol 2021 Mar 17;24(2):114-124. Epub 2020 Dec 17.

Comparative Ocular Pathology Lab of Wisconsin, Madison, WI, USA.

The objectives of this retrospective study were to evaluate the histopathologic changes associated with porcupine ocular quill injuries in dogs, to discuss the various methods of quill detection when quills are not grossly visible, and to discuss the pathogenesis of delayed ocular quill injuries in dogs. Seventeen globes sustaining ocular quilling injuries from 17 dogs (1986-2018) were identified in the COPLOW archives and the gross and histologic changes tabulated and compared. All cases were dogs, with one whole globe submitted from each patient. Read More

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Posner-Schlossman Syndrome in Common Variable Immunodeficiency.

Case Rep Ophthalmol Med 2020 15;2020:8843586. Epub 2020 Oct 15.

Allergy/Immunology Associates Inc., Mayfield Heights, Ohio, USA.

Introduction: Posner-Schlossman syndrome (PSS) is a rare glaucomatocyclitic crisis with clinical features including recurrent episodes of unilateral elevated intraocular pressure. Autoimmune and infectious causes have been proposed as potential etiologies of PSS. We report the first case of PSS in the setting of common variable immunodeficiency (CVID). Read More

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October 2020

Anterior uveitis following collagen crosslinking in a patient with X-linked chronic granulomatous disease.

Can J Ophthalmol 2021 Apr 17;56(2):e60-e62. Epub 2020 Oct 17.

Duke University Eye Center, Durham, NC. Electronic address:

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Evaluation of the outcome of long-tube shunt implant surgery in uveitic glaucoma patients by analyzing the background of uveitis.

Int Ophthalmol 2021 Feb 14;41(2):509-517. Epub 2020 Oct 14.

Department of Ophthalmology, Juntendo Urayasu Hospital, Urayasu, Japan.

Purpose: To evaluate the efficacy of long-tube shunt surgery (LTSS) without valve in uveitic glaucoma (UG) eyes.

Methods: We retrospectively analyzed the data of 45 UG eyes that underwent only LTSS or LTSS combined with trabeculectomy (TLE) (LTSS/TLE). The UG eyes were analyzed by categorizing them into granulomatous/non-granulomatous, steroid responder/non-responder, and primary open-angle glaucoma (POAG) (POAG background)/non-POAG (non-POAG background). Read More

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February 2021

A case of Vogt-Koyanagi-Harada-like uveitis secondary to dabrafenib/trametinib therapy for advanced melanoma.

Eur J Ophthalmol 2020 Oct 1:1120672120962044. Epub 2020 Oct 1.

Department of Ophthalmology, San Raffaele Scientific Institute, University Vita-Salute, Milan, Italy.

We report a case of ocular drug toxicity consistent with bilateral Vogt-Koyanagi-Harada (VKH) like disease in a patient with cutaneous melanoma treated with Dabrafenib/Trametinib therapy. A 53-year-old man with a history of metastatic cutaneous melanoma, treated with Dabrafenib/Trametinib, developed a severe acute panuveitis with granulomatous anterior uveitis and multiple serous retinal detachments. The ocular inflammatory reaction was classified as a bilateral Vogt-Koyanagi-Harada disease. Read More

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October 2020

Sympathetic Ophthalmia - a Contribution to Immunology, Clinic and Current Imaging.

Klin Monbl Augenheilkd 2020 Sep 23;237(9):1060-1069. Epub 2020 Sep 23.

Universitäts-Augenklinik, Charité Campus Virchow-Klinik, Berlin.

Background: Sympathetic ophthalmia (SO) is a rare inflammation of an operated or injured eye that spreads to the fellow eye. It is typically a bilateral granulomatous panuveitis. The traumatized eye is referred to as inciting eye and the fellow eye as sympathizing eye. Read More

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September 2020

Systemic sarcoidosis revealed by venepunctures: a very rare but rewarding cutaneous manifestation.

BMJ Case Rep 2020 Sep 7;13(9). Epub 2020 Sep 7.

Department of Internal Medicine, Centre Hospitalier Universitaire de Saint-Etienne, Saint-Etienne, Loire, France.

A 67-year-old man was referred to our department for the onset of cutaneous lesions following venepunctures. His recent medical history included brief flu-like syndrome, persistent cough, dyspnoea, dry mouth, blurred vision and weight loss. The extensive clinical, biological and radiological check-up showed signs consistent with systemic sarcoidosis: right uveitis, hypercalcemia, renal failure, inflammatory syndrome, elevated levels of ACE, alveolitis with elevated CD4+/CD8+ T cell ratio, hilar and mediastinal lymphadenopathy, bilateral pulmonary infiltrates, mild bronchial obstruction and lowered diffusing capacity of the lungs for carbon monoxide. Read More

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September 2020

Characteristics, evolution, and outcome of patients with non-infectious uveitis referred for rheumatologic assessment and management: an Egyptian multicenter retrospective study.

Clin Rheumatol 2021 Apr 2;40(4):1599-1610. Epub 2020 Sep 2.

Ophthalmology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Objective: To investigate the characteristics, evolution, and visual outcome of non-infectious uveitis.

Methodology: Records of 201 patients with non-infectious uveitis (136 (67.7%) males and 84 (41. Read More

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Acute bilateral granulomatous anterior uveitis as an extra-hepatic manifestation of hepatitis A virus (HAV) infection: a case report.

J Ophthalmic Inflamm Infect 2020 Aug 27;10(1):18. Epub 2020 Aug 27.

Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Anterior uveitis (AU) is the most common form of uveitis. The differential diagnosis of AU is broad, ranging from infectious etiologies to autoimmune causes. However, approximately half remain idiopathic. Read More

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Leptospiral uveitis in coastal Karnataka: A case report.

Indian J Ophthalmol 2020 Sep;68(9):1975-1976

Department of Microbiology, Kasturba Medical College - Manipal, Manipal Academy of Higher Education, Karnataka, India.

We report a case of a young male from Udupi, Karnataka, presenting with features of bilateral non-granulomatous anterior uveitis with mild vitritis. There was a history of fever and myalgia a month before ocular features, which was partially treated. He also gave a history of being actively involved in the flood relief work in the district, before the onset of fever. Read More

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September 2020

Clinical manifestations and outcomes of ocular syphilis in Asian Indian population: Analysis of cases presenting to a tertiary referral center.

Indian J Ophthalmol 2020 Sep;68(9):1881-1886

Smt Kannuri Santhamma Center for Vitreoretinal Diseases, L V Prasad Eye Institute, KAR Campus, Hyderabad, Telangana, India.

Purpose: To describe disease manifestations and outcomes of ocular syphilis in Asian Indian population.

Methods: Retrospective analysis of patients diagnosed with ocular syphilis at a tertiary referral center in India. Demographics, history, extraocular and ocular manifestations, ocular and systemic investigations, treatment and visual acuity outcomes were noted. Read More

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September 2020

Viral anterior uveitis.

Indian J Ophthalmol 2020 09;68(9):1764-1773

Centre for Ophthalmology, University of Tuebingen, Germany.

Viral anterior uveitis (VAU) needs to be suspected in anterior uveitis (AU) associated with elevated intraocular pressure, corneal involvement, and iris atrophic changes. Common etiologies of VAU include herpes simplex, varicella-zoster, cytomegalovirus, and rubella virus. Clinical presentations can vary from granulomatous AU with corneal involvement, Posner-Schlossman syndrome, Fuchs uveitis syndrome, and endothelitis. Read More

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September 2020

Delayed Acute Granulomatous Anterior Uveitis after Inadvertent Intraocular Injection of Tattoo Ink from a Scleral Tattoo Procedure.

Ocul Immunol Inflamm 2020 Aug 19:1-3. Epub 2020 Aug 19.

Department of Ophthalmology, University of California, San Francisco , San Francisco, CA, USA.

Purpose: To improve awareness of delayed onset uveitis in patients with a history of intraocular tattoo ink injection.

Results: A 47-year-old man underwent a scleral tattoo procedure during which there was inadvertent intraocular injection of tattoo ink into his right eye. He subsequently developed endophthalmitis, retinal detachment, and retinal necrosis. Read More

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Bilateral acute angle closure glaucoma as an initial presentation of Vogt-Koyanagi-Harada syndrome: A clinical case report.

Eur J Ophthalmol 2020 Aug 18:1120672120951442. Epub 2020 Aug 18.

Ophthalmologic Center, Qingdao Municipal Hospital, the Affiliated Municipal Hospital of Qingdao University, Qingdao 266071, Shandong Province, P.R. China.

Purpose: Vogt-Koyanagi-Harada (VKH) is an autoimmune disease with bilateral granulomatous uveitis and various systemic manifestations. Bilateral acute angle closure glaucoma (AACG) can be a rare initial manifestation of VKH that may be misdiagnosed as primary angle closure glaucoma (PACG).

Case Report: A 62-year-old woman with bilateral painless loss of vision referred to Qingdao Municipal Hospital. Read More

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Ocular Tuberculosis in HIV-infected Individuals.

Ocul Immunol Inflamm 2020 Nov 18;28(8):1251-1258. Epub 2020 Aug 18.

Advanced Eye Center, Post Graduate Institute , Chandigarh, India.

To review the current literature and publications to assess the clinical features, recommended investigations and treatment for ocular tuberculosis in HIV infected patients. Literature review. The human immunodeficiency virus (HIV) epidemic affects as many as 37. Read More

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November 2020

Treatment of Vogt-Koyanagi-Harada Disease.

Cureus 2020 Jul 11;12(7):e9125. Epub 2020 Jul 11.

Medicine, Jouf University, Sakaka, SAU.

Vogt-Koyanagi-Harada (VKH) disease is a T-cell-mediated autoimmune inflammatory disease characterized by granulomatous panuveitis with a variety of other systemic manifestations. A 29-year-old man referred with a two-week history of pain, redness, photophobia, and blurring of vision of the right eye. The patient reported a history of tinnitus and vertigo. Read More

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Acute unilateral anterior uveitis following zoledronic acid infusion: A case report.

SAGE Open Med Case Rep 2020 20;8:2050313X20944305. Epub 2020 Jul 20.

University Medical Unit, Teaching Hospital, Jaffna, Sri Lanka.

Bisphosphonates are widely used to treat several clinical conditions. Zoledronic acid is one of this class, commonly used for the treatment and prevention of osteoporosis, hypercalcemia of malignancy, Paget's disease, and multiple myeloma. A variety of ocular side effects associated with bisphosphonates therapy has been reported but are uncommon and readily treatable. Read More

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Vogt-Koyanagi-Harada disease-like uveitis following nivolumab administration treated with steroid pulse therapy: a case report.

BMC Ophthalmol 2020 Jun 24;20(1):252. Epub 2020 Jun 24.

Department of Ophthalmology, Kameda Medical Center, Kamogawa, Japan.

Background: Immune checkpoint inhibitors can cause various adverse effects. Recently it has been shown that Vogt-Koyanagi-Harada (VKH) disease-like uveitis can occur in patients treated with nivolumab.

Case Presentation: A 69-year-old man developed bilateral panuveitis after nivolumab treatment for recurrent hypopharyngeal cancer. Read More

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Bilateral uveitis associated with nivolumab therapy for metastatic non-small cell lung cancer.

Am J Ophthalmol Case Rep 2020 Jun 7;18:100691. Epub 2020 Apr 7.

Bascom Palmer Eye Institute And, University of Miami Miller School of Medicine 900 NW 17th Street, Miami, FL, 33136, USA.

Purpose: To report a case of bilateral uveitis secondary to intravenous nivolumab therapy in a patient with stage IV non-small cell lung cancer.

Observations: A 53-year-old male with stage IV non-small cell lung cancer presented with gradual onset of blurry vision in the left eye for nine days after completion of the first cycle of intravenous nivolumab chemotherapy. At initial presentation, best-corrected visual acuity was 20/25 in the right eye and 20/30 in the left eye. Read More

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A case of adult-onset tubulointerstitial nephritis and uveitis syndrome presenting with granulomatous panuveitis.

Taiwan J Ophthalmol 2020 Jan-Mar;10(1):66-70. Epub 2020 Mar 4.

Department of Pathology, Hacettepe University, Ankara, Turkey.

The tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disorder that is probably underdiagnosed in clinical practice. Ocular involvement in TINU syndrome not only presents with the nongranulomatous anterior uveitis in 80% of patients but also manifests as intermediate, posterior, or panuveitis. This case report mentions an adult male patient who presented with granulomatous iridocyclitis with panuveitis and mild renal insufficiency. Read More

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