484 results match your criteria Uveitis Anterior Granulomatous


Herpes Simplex Virus 1 Anterior Uveitis following Coronavirus Disease 2019 (COVID-19) Vaccination in an Asian Indian Female.

Ocul Immunol Inflamm 2022 Apr 11:1-5. Epub 2022 Apr 11.

Department of Cornea and Refractive Surgery, Narayana Nethralaya, Bangalore, India.

Purpose: To describe a case of herpes simplex virus 1 (HSV 1) infection following coronavirus disease 2019 (COVID-19) vaccination in an Asian Indian female.

Methods: Retrospective case report.

Result: A 40-year-old female presented with decreased vision, pain, and photophobia of 2 weeks duration. Read More

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Targeted Medical History and Diagnostic Testing in Uveitis.

Klin Monbl Augenheilkd 2022 May 23;239(5):654-658. Epub 2022 Mar 23.

Immunbiologie, Universitäts-Augenklinik München, Deutschland.

Uveitis is a collective term for a variety of different intraocular inflammations. The underlying etiologies vary greatly depending on the uveitis subtype, and in particular the anatomical focus. The most common forms of anterior uveitis are acute fibrinous unilateral uveitis, often associated with the HLA-B27 haplotype, and granulomatous inflammation, typically associated with sarcoidosis or herpes infections. Read More

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IgG4-related hypertensive granulomatous anterior uveitis.

Am J Ophthalmol Case Rep 2022 Jun 1;26:101465. Epub 2022 Mar 1.

Stein Eye Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Purpose: To report a case of hypertensive granulomatous anterior uveitis in the setting of IgG4-related disease (IgG4-RD).

Observations: A 69-year-old man presented with no light perception vision in both eyes and bilateral granulomatous anterior uveitis with iris neovascularization and hyphema in the right eye. He also demonstrated concurrent polyuria, polydipsia, and altered mental status, and was diagnosed with new-onset diabetes mellitus. Read More

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Brentuximab vedotin induced uveitis.

Am J Ophthalmol Case Rep 2022 Jun 18;26:101440. Epub 2022 Feb 18.

ZNA Middelheim, Lindendreef 1, 2020, Antwerp, Belgium.

Purpose: To report a case of bilateral Vogt-Koyanagi-Harada (VKH)-like granulomatous pan uveitis secondary to brentuximab vedotin (BV) administration to treat for classical Hodgkin lymphoma (CHL).

Observations: A case of bilateral pan uveitis is described, following administration of BV, with features of VKH-like uveitis: presence of inflammatory cells in the anterior and posterior segment, multiple small serous detachments around the optic disc and retinal pigment epithelium (RPE) folds confirmed by optical coherence tomography (OCT) as well as hypocyanesent dark dots, disc hyperfluorescence and fuzzy vascular patterns seen on indocyanine green and fluorescein angiography. There were no systemic features of VKH disease. Read More

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Intraocular inflammation secondary to intravitreal brolucizumab treated successfully with Sub-Tenon triamcinolone: A case report.

Am J Ophthalmol Case Rep 2022 Mar 22;25:101289. Epub 2022 Jan 22.

University of Puerto Rico, Medical Sciences Campus, School of Medicine, Department of Ophthalmology, San Juan, PR, USA.

Purpose: To report on a case of successful treatment of intraocular inflammation (IOI) secondary to brolucizumab intravitreal injection that responded to a single sub-Tenon injection of triamcinolone.

Observations: An 81-year-old female with a longstanding history of exudative age-related macular degeneration (AMD) was unresponsive to various regimens of -VEGF injections. Her AMD was treated with one intravitreal injection of brolucizumab (6mg/0. Read More

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Multimodal Imaging Approach in a Patient with Vogt-Koyanagi-Harada-like Syndrome Due to Dabrafenib and Trametinib Use for Cutaneous Melanoma.

Ocul Immunol Inflamm 2022 Feb 3:1-5. Epub 2022 Feb 3.

U.O. Oculistica 2, Turin Eye Hospital, ASL Città di Torino, Turin, Italy.

Purpose: To describe a case of ocular inflammation associated with dabrafenib and trametinib chemotherapy for cutaneous melanoma by using a multimodal image approach.

Materials And Methods: We report on a 51-year-old woman with Vogt-Koyanagi-Harada-like syndrome, which occurred while she was undergoing treatment with dabrafenib and trametinib for cutaneous melanoma. The patient complained of sudden, bilateral vision loss of 2 days' duration. Read More

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February 2022

Effectiveness of Baricitinib in Refractory Seronegative Rheumatoid Arthritis and Uveitis: A Case Report.

Front Med (Lausanne) 2021 14;8:764067. Epub 2022 Jan 14.

Department of Ophthalmology and Visual Sciences, Yamagata University Faculty of Medicine, Yamagata, Japan.

Baricitinib is a Janus kinase (JAK) inhibitor used to treat refractory rheumatoid arthritis and blocks the subtypes JAK1 and JAK2. A 35-year-old man with seronegative rheumatoid arthritis complicated by bilateral severe non-granulomatous panuveitis was resistant to steroid treatment, multiple conventional disease-modifying antirheumatic drugs (methotrexate and salazosulfapyridine), and TNF-α inhibitors (adalimumab and infliximab). Therefore, the TNF-α inhibitors were switched to baricitinib to decrease the activity of systemic arthritis. Read More

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January 2022

Case Series: Tattoo-associated Uveitis.

Optom Vis Sci 2022 Apr;99(4):383-388

Significance: Tattoo-associated uveitis describes simultaneous tattoo inflammation and uveitis. Multiple cases exist in the literature related to systemic sarcoidosis or a delayed hypersensitivity reaction; however, there is no consensus on etiology. Clinicians should consider new tattoos as an associated factor for patients presenting with a new uveitis. Read More

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Corneal Sarcoidosis: Diffuse Stromal Granulomatous Inflammation in a Patient With Sarcoidosis.

Cornea 2022 May;41(5):644-646

Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD. Dr. Shifera is now with the private practice in Zephyrhills, FL.

Purpose: The purpose of this study was to present a case of diffuse noncaseating granulomas involving the corneal stroma in a patient with ocular and pulmonary sarcoidosis.

Methods: This was a single case report.

Results: A 31-year-old female patient presented with a 6-year history of panuveitis of the right eye along with a history of pulmonary sarcoidosis and a conjunctival biopsy of the right eye that was reported as positive for sarcoidosis. Read More

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New Perspectives on the Immunopathogenesis and Treatment of Uveitis Associated With Vogt-Koyanagi-Harada Disease.

Front Med (Lausanne) 2021 12;8:705796. Epub 2021 Nov 12.

Laboratory of Immunobiology, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, University of Leuven, Leuven, Belgium.

Uveitis associated with Vogt-Koyanagi-Harada (VKH) disease is a bilateral, chronic, granulomatous autoimmune disease associated with vitiligo, poliosis, alopecia, and meningeal and auditory manifestations. The disease affects pigmented races with a predisposing genetic background. Evidence has been provided that the clinical manifestations are caused by a T-lymphocyte-mediated autoimmune response directed against antigens associated with melanocytes in the target organs. Read More

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November 2021

A case of systemic sarcoidosis with mesangial proliferative glomerulonephritis showing predominant deposition of IgG in the mesangial region.

CEN Case Rep 2022 May 9;11(2):231-236. Epub 2021 Nov 9.

Division of Kidney Center, St Luke's International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo, 104-8560, Japan.

A 37-year-old African-British man was referred to our hospital for detailed examination because of persistent fever, swelling and pain in both ankle joints, and blurred vision for two months. Inguinal lymph node biopsy showed a large number of epithelioid granulomas without necrosis. Granulomatous anterior uveitis, nephropathy, high serum angiotensin-converting enzyme activity, and high serum-soluble interleukin-2 receptor were observed, and the diagnosis of systemic sarcoidosis was made. Read More

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Clinical features of acute retinal necrosis with optic neuropathy and central retinal artery occlusion as initial manifestation.

Curr Mol Med 2021 Nov 4. Epub 2021 Nov 4.

Department of Ophthalmology, The Second Hospital of Jilin University, Changchun. China.

Background: Acute retinal necrosis normally occurs at the peripheral retina and gradually merges and progresses to the posterior pole. We report the case of a patient with optic neuropathy and central retinal vessels as the first manifestations of Acute retinal necrosis.

Case Presentation: A 56-year-old man was referred with a 10-day vision loss in his right eye. Read More

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November 2021

Sympathetic Ophthalmia: Where Do We Currently Stand on Treatment Strategies?

Clin Ophthalmol 2021 20;15:4201-4218. Epub 2021 Oct 20.

Department of Ophthalmology, All India Institute of Medical Sciences, New Delhi, 110029, India.

Sympathetic ophthalmia is a rare bilateral diffuse granulomatous panuveitis that usually results from surgical or penetrating trauma to one eye. The symptoms range from impaired near vision to pain, photophobia, and loss of visual acuity. Anterior segment manifestations include bilateral acute uveitis with mutton-fat keratic precipitates and posterior segment findings include vitritis, multifocal neurosensory retinal detachment, choroiditis, optic nerve edema, and Dalen-Fuchs nodules. Read More

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October 2021

On the Dangers of Tropical Spiders as a Pet: A Review of Ocular Symptoms Caused by Tarantula Hairs.

Am J Trop Med Hyg 2021 09 27;105(6):1795-1797. Epub 2021 Sep 27.

Department of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands.

Tarantulas are large spiders that can defend themselves by shedding urticating hairs (setae). In this paper, we aim to discuss the ocular conditions caused by these setae through a literature review. In total, 25 cases were identified in the PubMed database. Read More

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September 2021

Unilateral Retinal Arteritis and Macroaneurysm in Sarcoidosis.

Ocul Immunol Inflamm 2021 Aug 31:1-5. Epub 2021 Aug 31.

The Retina Service of Wills Eye Hospital, Mid Atlantic Retina, Philadelphia, Pennsylvania, USA.

Sarcoidosis, an idiopathic systemic disorder characterized by noncaseating granulomas, is often associated with granulomatous uveitis. Anterior segment involvement can present with mutton-fat keratic precipitates, anterior chamber cell, and iris nodules. Sarcoid associated posterior uveitis may present with vitritis, retinal vasculitis, and choroidal lesions. Read More

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Tick-borne encephalitis related uveitis: a case report.

BMC Ophthalmol 2021 Aug 28;21(1):315. Epub 2021 Aug 28.

Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, Fondation Asile des Aveugles, avenue de France 15, 1002, Lausanne, Switzerland.

Background: Tick-borne encephalitis (TBE) is an infectious disease of the central nervous system caused by the TBE virus (TBEV), which is usually transmitted by a tick-bite, with increasing incidence in northeastern Europe and eastern Asia during the past decade. Ocular involvement has not been described in the literature to date.

Case Presentation: A 58-year-old patient presented to the emergency department with occipital headaches and poor balance for 5 days. Read More

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SARS-CoV-2 among the Potential Viral Triggers for Vogt-Konayagi-Harada Disease: First Case Report and Literature Review.

Ocul Immunol Inflamm 2021 Aug 26:1-7. Epub 2021 Aug 26.

Department of Ophthalmology, Ministerio de Saludi8, Panama.

Objective: To describe a case of Vogt-Koyanagi-Harada (VKH) disease associated with the novel coronavirus disease 2019 (COVID-19).

Materials And Methods: A retrospective review of patient records was carried out to obtain data for a case report. A literature review was conducted of cases of uveitis associated with COVID-19 reported to date. Read More

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Ankylosing Spondylitis.

J Ophthalmic Vis Res 2021 Jul-Sep;16(3):462-469. Epub 2021 Jul 29.

Retina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

The seronegative spondyloarthropathies are a group of autoimmune inflammatory diseases lacking rheumatoid factor or antinuclear antibody in their serum. They include ankylosing spondylitis (AS), reactive arthritis, psoriatic arthritis, spondylitis associated with Crohn's disease and ulcerative colitis, and undifferentiated spondyloarthropathies. Inflammation mostly affects the axial joints, entheses, and extra-articular structures such as uveal tract, gastrointestinal tract, mucocutaneous tissue, and heart. Read More

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Sarcoidosis Presenting with Bilateral Optic Disc Edema as the Initial Presentation.

J Coll Physicians Surg Pak 2021 Jul;30(7):861-863

Department of Ophthalmology, Haydarpasa Numune Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

Sarcoidosis is a chronic, progressive, granulomatous inflammatory disease of unknown etiology that affects multiple organ systems. Granulomatous anterior uveitis is the most common eye finding, and optic nerve involvement at presentation is rarely seen. Here, we report a 43-year man referred to our clinic with eye pain, decreased vision, floaters and bilateral papillitis, vitritis and cystoid macular edema. Read More

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Vogt Koyanagi Harada Disease In Paediatric Age Group: Clinical Characteristics, Remission, Recurrences and Complications in Asian Indian Population.

Semin Ophthalmol 2022 Feb 5;37(2):187-192. Epub 2021 Jul 5.

The Cornea Institute, L.V. Prasad Eye Institute, Hyderabad, India.

Purpose: To describe disease characteristics and outcomes of Vogt-Koyanagi-Harada (VKH) syndrome in paediatric patients.

Study Design: Retrospective chart analysis.

Methods: A Retrospective: Analysis of all patients ≤16 years with VKH syndrome was done. Read More

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February 2022

"Post Coronavirus Disease (COVID-19) Reactivation of a Quiescent Unilateral Anterior Uveitis".

SN Compr Clin Med 2021 7;3(9):1843-1847. Epub 2021 Jun 7.

Department of Neuro-ophthalmology, Cornea and Refractive Surgery, Narayana Nethralaya, Bangalore, India.

Coronavirus disease (COVID-19) can be associated with ophthalmic manifestations like conjunctivitis, retinal haemorrhages, retinal vascular occlusions, papillophlebitis, and Adie's syndrome. We herein report for a case of a unilateral acute anterior uveitis which was quiescent for 13 years and was reactivated post COVID-19 infection in a 43-year-old Asian Indian male. He had a past history of recurrent unilateral granulomatous anterior and intermediate uveitis in the right eye (RE), and all the investigations done 14 years ago were negative and had been on treatment with topical and oral steroids. Read More

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When HIV Immunodeficiency and Heterochromia Confuse the Issue: Recurrent Zoster Uveitis Mistaken for Fuchs' Uveitis.

J Ophthalmic Vis Res 2021 Apr-Jun;16(2):295-299. Epub 2021 Apr 29.

Retinal and Inflammatory Eye Diseases, Centre for Ophthalmic Specialized Care (COS), Clinic Montchoisi Teaching Centre, Lausanne, Switzerland.

Purpose: We report a case with iris heterochromia misdiagnosed as Fuchs' uveitis which finally turned out to be a unilateral zoster uveitis in an HIV-positive patient.

Case Report: A 45-year old patient was seen for a recurrent right anterior uveitis treated with prednisolone 1% drops BID. The iris of the right eye was hypochromic and atrophic and several small granulomatous keratic precipitates (KPs) were present. Read More

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Characteristics of Childhood Presumed Trematode-Induced Granulomatous Anterior Uveitis Using Ultrasound Biomicroscopy.

Ocul Immunol Inflamm 2021 May 20:1-5. Epub 2021 May 20.

Department of Ophthalmology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

To investigate the UBM characteristics of presumed trematode-induced granulomatous uveitis. Prospective case series. Thirty patients who presented with anterior chamber (AC) granuloma were included. Read More

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Uveitic Glaucoma and Hansen's disease, A case report.

Am J Ophthalmol Case Rep 2021 Jun 22;22:101096. Epub 2021 Apr 22.

Instituto de Oftalmología y Glaucoma Vásquez, Hospital Metropolitano, Quito, Ecuador.

Background: The number of Hansen's disease cases in Latin America and the Caribbean has decreased in the last decade; nevertheless, the region is still struggling with infections caused by This is a case report that portrays the diagnostic and management challenges associated with atypical uveitic glaucoma that is due to Hansen's disease.

Case Presentation: A 62-year-old female was referred with a 2-year history of anterior uveitis of unknown etiology and ocular hypertension. Past medical history and general physical examination were unremarkable. Read More

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Diagnostic features of the presumed focal viral retinitis: A case series.

Authors:
Anu Manandhar

Nepal J Ophthalmol 2020 Jul;12(24):339-346

Tilganga Institute of Ophthalmology, Gaushala, Kathmandu, Nepal.

Introduction: Other than well-known herpetic retinopathies like acute retinal necrosis, progressive outer retinal necrosis and cytomegalovirus retinitis, there are few reports on atypical forms of viral retinitis caused by herpes virus from around the world.

Cases: Presenting symptom was sudden onset of diminution of vision in all 6 cases. Mean duration of symptoms at presentation was 7. Read More

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Bilateral Acute Anterior Uveitis and Corneal Punctate Epitheliopathy in Children Diagnosed with Multisystem Inflammatory Syndrome Secondary to COVID-19.

Ocul Immunol Inflamm 2021 May 15;29(4):700-704. Epub 2021 Apr 15.

Department of Pediatric Infectious Diseases, Health Sciences University, Dr. Sami Ulus Education and Research Hospital, Ankara, Turkey.

: To report bilateral anterior uveitis and corneal punctate epitheliopathy in children with multisystem inflammatory syndrome (MIS-C) secondary to coronavirus disease (COVID-19).: Five patients who were positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies and diagnosed with MIS-C were evaluated. Ophthalmologic examinations were performed in order to reveal ocular findings in MIS-C disease. Read More

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Epidemiology of Childhood Uveitis in a Tertiary Care Center: A 20-Year Study.

Klin Monbl Augenheilkd 2021 Apr 14;238(4):469-473. Epub 2021 Apr 14.

Jules-Gonin Eye Hospital, Department of Ophthalmology, University of Lausanne, Lausanne, Switzerland.

Purpose: To investigate demographics and causes of pediatric uveitis in a Swiss tertiary reference center over a 20-year period.

Materials And Methods: Retrospective cohort study on patients with uveitis aged less than 16 years seen at Jules-Gonin Eye Hospital between 1 January 2000 and 31 December 2019.

Results: Out of 2846 patients with uveitis seen in the Jules-Gonin Eye Hospital Ocular Immune-Infectiology Department, 317 (11. Read More

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Keratic Precipitates: The Underutilized Diagnostic Clue.

Ocul Immunol Inflamm 2021 May 7;29(4):776-785. Epub 2021 Apr 7.

Singapore National Eye Centre, Singapore, Singapore.

The morphology of keratic precipitates (KPs) may yield important diagnostic clues. However, KPs have not been described in a standardized manner and the traditional classification of granulomatous or non-granulomatous KPs is not helpful in differentiating infectious from noninfectious uveitis. A granulomatous uveitis may initially appear non-granulomatous. Read More

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