130 results match your criteria Uveitis Anterior Childhood


Complication and prognosis of juvenile idiopathic arthritis associated uveitis in the era of modern immunomodulatory treatment.

Psychiatr Danub 2019 Mar;31(Suppl 1):44-49

Zagreb University Hospital Centre, Department of Ophthalmology, Kišpatićeva 12, 10000 Zagreb, Croatia,

JIA is the most common rheumatic disease of childhood and JIA-U is its most frequent and most devastating extraarticular manifestation. This form of uveitis is usually asymptomatic, chronic anterior uveitis, often accompained with complications. JIA-U is the main cause of vision loss and even blidness in childhood. Read More

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March 2019
1 Read

[Therapeutic options in juvenile idiopathic arthritis : Part 1: Nonsurgical treatment].

Authors:
J-P Haas M Arbogast

Orthopade 2018 Nov;47(11):910-916

Abteilung für Rheumaorthopädie und Handchirurgie, Zentrum für Rheumatologie, Orthopädie und Schmerztherapie, Klinik Oberammergau, Oberammergau, Deutschland.

The treatment of children and adolescents with juvenile idiopathic arthritis (JIA) has progressed substantially during recent years. Multiple different factors have played a role in this advancement: improved medical treatment due to the introduction of new drugs, structural improvements with provision of units specializing in childhood rheumatology, multidisciplinary treatment concepts, structured educational programs for patients and parents, improved functional treatment including sports therapy, and selective surgical and orthopedic interventions improving functional capacities. Current treatment strategies in JIA are aimed at achieving disease remission, i. Read More

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http://link.springer.com/10.1007/s00132-018-3645-1
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http://dx.doi.org/10.1007/s00132-018-3645-1DOI Listing
November 2018
4 Reads

Childhood Arthritis and Rheumatology Research Alliance Consensus Treatment Plans for Juvenile Idiopathic Arthritis-Associated and Idiopathic Chronic Anterior Uveitis.

Arthritis Care Res (Hoboken) 2019 Apr;71(4):482-491

Duke University Medical Center, Durham, North Carolina.

Objective: Systemic immunosuppressive treatment of pediatric chronic anterior uveitis (CAU), both juvenile idiopathic arthritis-associated and idiopathic anterior uveitis, varies, making it difficult to identify best treatments. The Childhood Arthritis and Rheumatology Research Alliance (CARRA) developed consensus treatment plans (CTPs) for CAU for the purpose of reducing practice variability and allowing future comparison of treatments using comparative effectiveness analysis techniques.

Methods: A core group of pediatric rheumatologists, ophthalmologists with uveitis expertise, and a lay advisor comprised the CARRA uveitis workgroup that performed a literature review on pharmacologic treatments, held teleconferences, and developed a case-based survey administered to the CARRA membership to delineate treatment practices. Read More

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http://dx.doi.org/10.1002/acr.23610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261704PMC
April 2019
14 Reads

Patterns of uveitis in children at the apex institute for eye care in India: analysis and review of literature.

Int Ophthalmol 2018 Oct 31;38(5):2061-2068. Epub 2017 Aug 31.

Retina and Uvea Services, Dr R P Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.

Aim: To study patterns of uveitis in Indian children and compare with data sets published earlier in the literature.

Methods: Consecutive patients below 16 years of age presenting to the uvea clinic of a tertiary eye care center were included prospectively through the period of July 2009-August 2013. Children with retinal vasculitis, exogenous endophthalmitis and masquerade syndromes were excluded from analysis. Read More

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http://dx.doi.org/10.1007/s10792-017-0700-6DOI Listing
October 2018
45 Reads

Sex Differences in Pediatric Rheumatology.

Clin Rev Allergy Immunol 2017 Aug 28. Epub 2017 Aug 28.

Anna Meyer Children's Hospital and University of Florence, Viale Pieraccini 24, 50139, Florence, Italy.

Autoimmune diseases affect up to 10% of the world's population and, as a whole, they are far more common in females, although differences exist according to the single disease and also in different age groups. In childhood-onset autoimmune diseases, the sex bias is generally less evident than in adults, probably for the different hormonal milieau, being estrogens strongly implicated in the development of autoimmunity. Still, some rheumatic conditions, such as juvenile idiopathic arthritis (JIA), show a strong predilection for girls (F:M = 3-6. Read More

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http://dx.doi.org/10.1007/s12016-017-8642-3DOI Listing
August 2017
4 Reads

Juvenile Idiopathic Arthritis.

Balkan Med J 2017 Apr;34(2):90-101

Department of Pediatric Rheumatology, İstanbul University Cerrahpaşa Medical School, İstanbul, Turkey.

Juvenile idiopathic arthritis is the most common chronic rheumatic disease of unknown aetiology in childhood and predominantly presents with peripheral arthritis. The disease is divided into several subgroups, according to demographic characteristics, clinical features, treatment modalities and disease prognosis. Systemic juvenile idiopathic arthritis, which is one of the most frequent disease subtypes, is characterized by recurrent fever and rash. Read More

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http://dx.doi.org/10.4274/balkanmedj.2017.0111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394305PMC
April 2017
4 Reads

[Social Medical Consequences of Uveitis in Childhood and Adolescence: Results of a Pilot Study].

Klin Monbl Augenheilkd 2017 Sep 13;234(9):1174-1178. Epub 2017 Jan 13.

Uveitis-Zentrum, Augenärzte am St. Franziskus Hospital, Münster.

Chronic illness - such as uveitis - may lead to socio-economic consequences, and poorer quality of life. To study the influence of uveitis on quality of life and professional development. Prospective evaluation of juvenile patients with uveitis (age < 18 years, classification of uveitis as in Standardization of Uveitis Nomenclature [SUN] criteria, duration of disease ≥ 12 months) seen in a tertiary referral centre. Read More

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http://dx.doi.org/10.1055/s-0042-120276DOI Listing
September 2017

Ocular involvement associated with varicella in adults.

J Ophthalmic Inflamm Infect 2016 Dec 28;6(1):47. Epub 2016 Nov 28.

Department of Ophthalmology, Fattouma Bourguiba University Hospital, Faculty of Medicine, University of Monastir, Monastir, Tunisia.

Background: Varicella is a common infectious disease primarily of childhood that is usually benign and self-limited. It is, however, increasingly seen in adults who are at a higher risk of severe infection. Ocular complications of varicella are relatively uncommon and have been rarely described in adults. Read More

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http://dx.doi.org/10.1186/s12348-016-0117-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126028PMC
December 2016
7 Reads

Juvenile Spondyloarthropathies.

Curr Rheumatol Rep 2016 08;18(8):55

Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.

Juvenile spondyloarthropathies represent a clinical entity separate from the adult disease. Initial clinical signs of juvenile spondyloarthropathies often include lower extremity arthritis and enthesopathy, without axial involvement at the disease onset. Asymmetrical oligoarthritis of lower extremities is typically seen in this type of arthritis. Read More

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http://dx.doi.org/10.1007/s11926-016-0603-yDOI Listing
August 2016
8 Reads

Juvenile idiopathic arthritis-associated uveitis.

Pediatr Rheumatol Online J 2016 Apr 27;14(1):27. Epub 2016 Apr 27.

Department of Paediatric Rheumatology, Bristol Royal Hospital for Children, Upper Maudlin Street, Bristol, BS2 8BJ, UK.

Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease of childhood, with JIA-associated uveitis its most common extra-articular manifestation. JIA-associated uveitis is a potentially sight-threatening condition and thus carries a considerable risk of morbidity. The aetiology of the condition is autoimmune in nature with the predominant involvement of CD4(+) T cells. Read More

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http://dx.doi.org/10.1186/s12969-016-0088-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848803PMC
April 2016
15 Reads

Ocular Fluid Analysis in Children Reveals Interleukin-29/Interferon-λ1 as a Biomarker for Juvenile Idiopathic Arthritis-Associated Uveitis.

Arthritis Rheumatol 2016 07;68(7):1769-79

Utrecht University Medical Center, Utrecht, The Netherlands.

Objective: Childhood uveitis is a vision-threatening inflammatory eye disease commonly attributed to juvenile idiopathic arthritis (JIA). The pathogenesis is poorly understood, which makes clinical management challenging. We analyzed soluble mediators in ocular fluid (aqueous humor [AqH]) and serum from children with JIA-associated uveitis and common childhood uveitis to identify potential biomarkers and investigate the ocular microenvironment of this sight-threatening eye disease. Read More

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http://dx.doi.org/10.1002/art.39621DOI Listing
July 2016
19 Reads

Current Treatment Modalities of JIA-associated Uveitis and its Complications: Literature Review.

Ocul Immunol Inflamm 2016 Aug 14;24(4):431-9. Epub 2016 Jan 14.

a Massachusetts Eye Research and Surgery Institution (MERSI) , Waltham , Massachusetts , USA.

Uveitis is a common and serious complication of juvenile idiopathic arthritis. Up to 75% of all cases of anterior uveitis in childhood are associated with juvenile idiopathic arthritis. Despite the remarkable progress in early detection and treatment of inflammation, vision-threatening complications of uveitis still occur in almost 60% of patients. Read More

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http://dx.doi.org/10.3109/09273948.2015.1115878DOI Listing
August 2016
2 Reads

Elevated S100A8/A9 and S100A12 Serum Levels Reflect Intraocular Inflammation in Juvenile Idiopathic Arthritis-Associated Uveitis: Results From a Pilot Study.

Invest Ophthalmol Vis Sci 2015 Dec;56(13):7653-60

Department of Pediatric Rheumatology and Immunology, University Hospital Muenster, Muenster, Germany.

Purpose: Juvenile idiopathic arthritis-associated uveitis (JIAU) is the most common uveitis entity in childhood. As S100A8/A9 and S100A12 proteins are valuable biomarkers in childhood arthritis, we investigated the occurrence of these proteins in childhood uveitis.

Methods: Serum samples from patients with JIAU (n = 79) or idiopathic anterior uveitis (IAU, n = 24), as well as from nonuveitic controls (n = 24), were collected. Read More

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http://dx.doi.org/10.1167/iovs.15-17066DOI Listing
December 2015
14 Reads

Managing juvenile idiopathic arthritis-associated uveitis.

Surv Ophthalmol 2016 Mar-Apr;61(2):197-210. Epub 2015 Oct 24.

Retinal Treatment and Research Unit, Bristol Eye Hospital, Bristol, UK. Electronic address:

Bilateral chronic anterior uveitis is an extra-articular feature of juvenile idiopathic arthritis. Although figures vary, uveitis occurs in approximately 11%-13% of patients with this disease and is most commonly associated with the female gender, oligoarthritis, and presence of antinuclear antibodies. The disease has an insidious onset and is often asymptomatic. Read More

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http://dx.doi.org/10.1016/j.survophthal.2015.10.005DOI Listing
September 2016
12 Reads

Infiltration of Plasma Cells in the Iris of Children With ANA-Positive Anterior Uveitis.

Invest Ophthalmol Vis Sci 2015 Oct;56(11):6770-8

Department of Ophthalmology University Medical Center Utrecht, Utrecht, The Netherlands.

Purpose: We investigated inflammatory cell infiltrates in iris biopsies in uveitis associated with juvenile idiopathic arthritis (JIA) in comparison with other pediatric uveitis entities and noninflammatory pediatric controls.

Methods: Iridectomy specimens were obtained during elective trabeculectomy from 31 eyes of 25 patients: 12 eyes with JIA-associated uveitis, 13 eyes with other uveitis entities, and 6 eyes with open angle nonuveitic juvenile glaucoma. Histopathologic and immunohistochemical analyses were performed. Read More

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http://dx.doi.org/10.1167/iovs.15-17351DOI Listing
October 2015
2 Reads

Mycophenolate sodium for the treatment of chronic non-infectious uveitis of childhood.

Br J Ophthalmol 2016 08 13;100(8):1071-5. Epub 2015 Nov 13.

Centre for Ophthalmology, University of Tuebingen, Tuebingen, Germany.

Aim: To assess the efficacy and tolerability of mycophenolate sodium (MPS) in the therapy of children with chronic non-infectious uveitis.

Methods: Retrospective analysis of 23 children with chronic uveitis, treated with MPS, with a follow-up of at least 6 months. The main outcome measures were time to uveitis reactivation and corticosteroid-sparing effect under MPS treatment. Read More

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http://bjo.bmj.com/content/early/2015/11/13/bjophthalmol-201
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http://bjo.bmj.com/cgi/doi/10.1136/bjophthalmol-2015-306701
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http://dx.doi.org/10.1136/bjophthalmol-2015-306701DOI Listing
August 2016
1 Read

Enthesitis-related arthritis.

Clin Rheumatol 2015 Nov 2;34(11):1839-46. Epub 2015 Aug 2.

Department of Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Rae Bareily Road, Lucknow, Uttar Pradesh, 226014, India.

Juvenile idiopathic arthritis (JIA) is the most common chronic arthritis of childhood. Currently, it is characterized by seven categories. The enthesitis-related arthritis (ERA) category usually affects boys older than 6 years and presents with lower limb asymmetrical arthritis associated with enthesitis. Read More

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http://dx.doi.org/10.1007/s10067-015-3029-4DOI Listing
November 2015
8 Reads
3 Citations
1.774 Impact Factor

Causes of uveitis in children without juvenile idiopathic arthritis.

Clin Ophthalmol 2015 25;9:1121-8. Epub 2015 Jun 25.

Department of Ophthalmology, University of Virginia, Charlottesville, VA, USA.

Background: The purpose of this study was to report the demographics, disease characteristics, treatments, and visual outcomes of pediatric uveitis patients without juvenile idiopathic arthritis managed in a tertiary medical center.

Methods: A retrospective, observational study was performed in pediatric uveitis patients without juvenile idiopathic arthritis and aged 0-18 years, who were seen at the University of Virginia from 1984 to 2014.

Results: Thirty-nine pediatric uveitis patients (57 eyes) were identified. Read More

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http://dx.doi.org/10.2147/OPTH.S83950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4485847PMC
July 2015
2 Reads

Using the Effects of Youngsters' Eyesight on Quality of Life Questionnaire to Measure Visual Outcomes in Children With Uveitis.

Arthritis Care Res (Hoboken) 2015 Nov;67(11):1513-20

Emory University School of Medicine and Rollins School of Public Health, Emory University, Atlanta, Georgia.

Objective: The Effects of Youngsters' Eyesight on Quality of Life (EYE-Q) is a novel measure of vision-related quality of life (QOL) and function in children. We aim to determine the validity of the EYE-Q in childhood uveitis.

Methods: We abstracted medical record data on arthritis and uveitis in a convenience sample of children with juvenile idiopathic arthritis (JIA) and/or uveitis. Read More

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http://dx.doi.org/10.1002/acr.22627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624475PMC
November 2015
7 Reads

Ophthalmic manifestations of relapsing acute childhood leukemia.

J AAPOS 2015 Jun 15;19(3):284-6. Epub 2015 Apr 15.

Vanderbilt Eye Institute, Nashville, Tennessee; Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee.

Acute lymphoblastic leukemia is the most common malignancy in children. We report 3 patients who presented to their general pediatricians and pediatric oncologists with ocular complaints as the only evidence of their leukemic relapses. All patients presented with persistent conjunctival injection and were referred to an ophthalmologist for further management. Read More

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http://dx.doi.org/10.1016/j.jaapos.2015.02.002DOI Listing
June 2015
5 Reads

Clinical manifestation of Fuchs uveitis syndrome in childhood.

Graefes Arch Clin Exp Ophthalmol 2015 Jul 19;253(7):1169-74. Epub 2015 Feb 19.

Department of Ophthalmology, St. Franziskus Hospital, Hohenzollernring 74, 48145, Münster, Germany.

Purpose: The aim of this study was to describe clinical signs and complications of Fuchs uveitis syndrome (FUS) with onset in childhood.

Methods: Ophthalmologic findings and complications in patients with FUS becoming manifest before the age of 16 years were analyzed in a retrospective study at a tertiary referral uveitis center. Inclusion criteria were the presence of pathognomonic FUS findings at any time point and exclusion of any systemic immune-mediated or infectious disease. Read More

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http://dx.doi.org/10.1007/s00417-015-2960-zDOI Listing
July 2015
4 Reads

[Epidemiologic profile of juvenile-onset compared to adult-onset spondyloarthritis in a large Brazilian cohort].

Rev Bras Reumatol 2014 Nov-Dec;54(6):424-30. Epub 2014 Sep 28.

Divisão de Reumatologia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brasil. Electronic address:

Objective: To analyze the clinical and epidemiologic characteristics of juvenile-onset spondyloarthritis (SpA) (< 16 years) and compare them with a group of adult-onset (≥ 16 years) SpA patients.

Patients And Methods: Prospective, observational and multicentric cohort with 1,424 patients with the diagnosis of SpA according to the European Spondyloarthropathy Study Group (ESSG) submitted to a common protocol of investigation and recruited in 29 reference centers participants of the Brazilian Registry of Spondyloarthritis (RBE - Registro Brasileiro de Espondiloartrites). Patients were divided in two groups: age at onset<16 years (JOSpA group) and age at onset ≥ 16 years (AOSpA group). Read More

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http://dx.doi.org/10.1016/j.rbr.2014.06.005DOI Listing
December 2016
75 Reads

Optic nerve and retinal features in uveitis associated with juvenile systemic granulomatous disease (Blau syndrome).

Acta Ophthalmol 2015 May 10;93(3):253-7. Epub 2014 Sep 10.

Bristol Eye Hospital, University Hospitals Bristol NHS Foundation Trust, Bristol, UK.

Purpose: To determine whether patients with juvenile systemic granulomatous disease (JSGD) (Blau syndrome) and uveitis have a characteristic ocular phenotype.

Methods: Clinical and imaging data were collected retrospectively from patients attending the Regional Combined Paediatric Rheumatology and Ocular Inflammatory Service, Bristol Eye Hospital. General demographic information, laterality of the uveitis, age at onset, anatomical classification and course of the uveitis, clinical phenotype and specific NOD2 mutation were recorded for each patient. Read More

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http://dx.doi.org/10.1111/aos.12544DOI Listing
May 2015
7 Reads

Pathogenesis of juvenile idiopathic arthritis associated uveitis: the known and unknown.

Surv Ophthalmol 2014 Sep-Oct;59(5):517-31. Epub 2014 Mar 29.

Department of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands.

Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease and the most prevalent systemic disorder in children with uveitis. The current prevailing opinion is that JIA is a multifactorial, genetically predisposed autoimmune disorder that can be influenced by environmental factors and infections; the specific pathogenesis of JIA-associated uveitis is not understood, however, nor has the relationship between the eye and joint inflammation been established. Nevertheless, subtypes of JIA that are associated with uveitis, oligoarthritis, polyarticular rheumatoid factor negative, and psoriatic arthritis appear to have common pathogenicity. Read More

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http://dx.doi.org/10.1016/j.survophthal.2014.03.002DOI Listing
March 2015
5 Reads

Ocular Involvement in Juvenile Idiopathic Arthritis: Classification and Treatment.

Authors:
Ivan Foeldvari

Clin Rev Allergy Immunol 2015 Dec;49(3):271-7

Hamburger Zentrum für Kinder- und Jugendrheumatologie am Klinikum Eilbek, Dehnhaide 120, 22081, Hamburg, Germany.

Juvenile idiopathic arthritis (JIA) is one of the most common rheumatic diseases in childhood with a prevalence of 4 in 1,000 children. Anterior uveitis is a well-known threatening comorbid condition of JIA and affects around 10 % of the patients depending on JIA subtype. A large proportion of children with JIA develop uveitis in the first year of disease and 73 to 90 % after 4 years. Read More

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http://dx.doi.org/10.1007/s12016-014-8436-9DOI Listing
December 2015
2 Reads

Treatment of uveitis associated with juvenile idiopathic arthritis.

Curr Rheumatol Rep 2014 Aug;16(8):437

Pediatric Rheumatology Unit. Hospital Sant Joan de Déu, Universitat de Barcelona, Passeig Sant Joan de Déu 2, 08950, Esplugues, Barcelona, Spain,

Chronic anterior uveitis affects 10-30 % of patients with juvenile idiopathic arthritis (JIA) and is still a cause of blindness in childhood. In most patients it is asymptomatic, bilateral, and recurrent, so careful screening and early diagnosis are important to obtain the best long-term prognosis. The treatment of chronic uveitis associated with JIA is challenging. Read More

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http://dx.doi.org/10.1007/s11926-014-0437-4DOI Listing
August 2014
3 Reads

Acute retinal necrosis in childhood.

Case Rep Ophthalmol 2014 May 14;5(2):138-43. Epub 2014 May 14.

Tzameret Medical Track, Hebrew University, Jerusalem, Israel ; Department of Ophthalmology, Ziv Medical Center, Safed, Israel ; Faculty of Medicine, Bar Ilan University, Safed, Israel.

Background: Acute retinal necrosis (ARN) is a viral syndrome consisting of uveitis/vitritis, occlusive vasculitis and peripheral necrosis. Few incidents are reported in children. The etiology is reactivated herpes simplex virus (HSV) or varicella-zoster virus (VZV). Read More

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http://dx.doi.org/10.1159/000363130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049010PMC
May 2014
2 Reads

A new rosette in retinoblastoma.

Indian J Ophthalmol 2014 May;62(5):638-41

Department of Ocular Pathology, Uveitis and Neuro-Ophthalmology Services; Sri Sankaradeva Nethralaya, Guwahati, Assam, India.

Retinoblastoma, the most common primary malignant intraocular tumor of childhood is a great success story in pediatric and ocular oncology. Pathology of retinoblastoma is important to guide the treatment modalities. Differentiated retinoblastoma is commonly seen in younger age group. Read More

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http://dx.doi.org/10.4103/0301-4738.129786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065523PMC
May 2014
8 Reads
4 Citations
0.930 Impact Factor

Description of a new family with cryopyrin-associated periodic syndrome: risk of visual loss in patients bearing the R260W mutation.

Rheumatology (Oxford) 2014 Jun;53(6):1095-9

Objective: The aim of this study was to describe a family with cryopyrin-associated periodic syndrome (CAPS) in which the disease was unveiled after the ophthalmologic evaluation.

Methods: Family and personal histories from each of the patients were recorded. Each underwent a full ophthalmological examination along with the physical examination. Read More

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http://dx.doi.org/10.1093/rheumatology/ket486DOI Listing
June 2014
9 Reads

Neisseria meningitidis endogenous endophthalmitis with meningitis in an immunocompetent child.

Ocul Immunol Inflamm 2014 Oct 2;22(5):398-402. Epub 2013 Dec 2.

Stoke Mandeville Hospital, Department of Ophthalmology , Mandeville Road, Aylesbury , UK.

Neisseria meningitidis is a major cause of childhood morbidity and mortality worldwide. We describe an exceptional case of an immunocompetent 15-month-old child presenting with a unilateral anterior uveitis, hypopyon, and sepsis. Anterior chamber aspirate demonstrated gram-negative cocci before Neisseria meningitidis was identified in blood and cerebrospinal fluid. Read More

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http://dx.doi.org/10.3109/09273948.2013.854392DOI Listing
October 2014
2 Reads

The safety and efficacy of noncorticosteroid triple immunosuppressive therapy in the treatment of refractory chronic noninfectious uveitis in childhood.

J Rheumatol 2014 Jan 1;41(1):136-9. Epub 2013 Oct 1.

From the School of Clinical Sciences, Faculty of Medicine and Dentistry, University of Bristol; Department of Pediatric Rheumatology, Bristol Royal Hospital for Children; Bristol Eye Hospital; Inflammation and Immunotherapy Theme, National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital National Health Service (NHS) Foundation Trust and University College London (UCL) Institute of Ophthalmology, University Hospitals Bristol NHS Foundation Trust and University of Bristol, Bristol, England.

Objective: To assess the safety and efficacy of noncorticosteroid triple immunosuppressive therapy in the treatment of refractory chronic noninfectious childhood uveitis.

Methods: Subjects were retrospectively selected from a database. Patients were included if they were diagnosed with chronic, noninfectious uveitis at 16 years of age or under and treated with triple immunosuppressive therapy for at least 6 months (following failure of a combination of 2 immunosuppressants). Read More

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http://dx.doi.org/10.3899/jrheum.130594DOI Listing
January 2014
1 Read

Juvenile idiopathic arthritis-associated uveitis: clinical features and complications, risk factors for severe course, and visual outcome.

Ocul Immunol Inflamm 2013 Dec 19;21(6):478-85. Epub 2013 Aug 19.

John A. Moran Eye Center, Salt Lake City , Utah , USA .

Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease and the most prevalent systemic disorder in children with uveitis. The risk of developing uveitis is the greatest among patients with oligoarticular onset of disease. Clinical features of JIA-associated uveitis (JIAU) are nongranulomatous inflammation, anterior in location, insidious at onset, chronic course, and frequently asymptomatic in the absence of ocular structural complications. Read More

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http://dx.doi.org/10.3109/09273948.2013.815785DOI Listing
December 2013
7 Reads

Use of adalimumab in refractory non-infectious childhood chronic uveitis: efficacy in ocular disease--a case cohort interventional study.

Rheumatology (Oxford) 2012 Dec 25;51(12):2199-203. Epub 2012 Aug 25.

Department of Paediatric Rheumatology, Bristol Royal Hospital for Children, Bristol, UK.

Objective: To assess the use of adalimumab in the treatment of refractory non-infectious childhood chronic uveitis.

Methods: A case cohort interventional study was performed on patients with uveitis, who were treated with adalimumab after failure of treatment with a combination of corticosteroids and another immunosuppressant drug. Main outcome measures were (i) stability of vision, (ii) stability of inflammation and (iii) reduction of immunosuppressive load. Read More

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http://dx.doi.org/10.1093/rheumatology/kes212DOI Listing
December 2012
1 Read

The masquerades of a childhood ciliary body medulloepithelioma: a case of chronic uveitis, cataract, and secondary glaucoma.

Case Rep Ophthalmol Med 2012 4;2012:493493. Epub 2012 Apr 4.

Moorfields Eye Hospital, City Road, London EC1V 2PD, UK.

Ciliary body medulloepitheliomas in childhood often masquerade other intraocular conditions due to its insidious nature as well as its secondary effects on proximal intraocular tissues in the anterior chamber. We report a case where a ciliary body medulloepithelioma in a two-year-old boy presents with chronic uveitis, cataract, and an uncontrolled secondary glaucoma after an innocuous blunt ocular trauma. The diagnosis was only made after the occurrence of a ciliary body mass. Read More

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http://downloads.hindawi.com/journals/criopm/2012/493493.pdf
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http://www.hindawi.com/journals/criopm/2012/493493/
Publisher Site
http://dx.doi.org/10.1155/2012/493493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350208PMC
August 2012
2 Reads

Proposed outcome measures for prospective clinical trials in juvenile idiopathic arthritis-associated uveitis: a consensus effort from the multinational interdisciplinary working group for uveitis in childhood.

Arthritis Care Res (Hoboken) 2012 Sep;64(9):1365-72

University of Duisburg Essen, Muenster, Germany.

Objective: To develop a set of core outcome measures for use in randomized controlled trials (RCTs) and longitudinal observational studies in juvenile idiopathic arthritis (JIA)-associated uveitis.

Methods: The literature relating to outcome measures used in studies of uveitis in childhood and adolescence was reviewed. A set of core outcomes and domains was established using the Delphi process. Read More

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http://doi.wiley.com/10.1002/acr.21674
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http://dx.doi.org/10.1002/acr.21674DOI Listing
September 2012
16 Reads

The clinical course of juvenile idiopathic arthritis-associated uveitis in childhood and puberty.

Br J Ophthalmol 2012 Jun 7;96(6):852-6. Epub 2012 Mar 7.

Department of Ophthalmology University Medical Center Utrecht, Postbus 85500, 3508 CX Utrecht, The Netherlands.

Aim: The long-term course of juvenile idiopathic arthritis (JIA)-associated uveitis is not known yet. This study investigates the course and activity of JIA-associated uveitis in childhood and puberty.

Design: Retrospective study of the clinical data of 62 JIA patients with uveitis. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2011-301023DOI Listing
June 2012
3 Reads

[Uveitis: diagnostic approach].

Rev Clin Esp 2012 Oct 31;212(9):442-52. Epub 2012 Jan 31.

Sección de Enfermedades Autoinmunes Sistémicas, Servicio de Medicina Interna, Hospital de Cruces, Vizcaya, España.

A 32 year-old woman was referred from the Ophthalmology Department to rule out a possible systemic disease. Her only past medical history of relevance was a tuberculosis contact during childhood. She complained of floaters and progressive blurring of vision in both eyes for some months, as well as arthralgia and cough. Read More

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http://dx.doi.org/10.1016/j.rce.2011.12.004DOI Listing
October 2012
1 Read

Treatment strategies for childhood noninfectious chronic uveitis: an update.

Expert Opin Investig Drugs 2012 Jan 11;21(1):1-6. Epub 2011 Nov 11.

Background: Uveitis is an inflammatory disorder involving inflammation of the uveal tract. It is classified as anterior, intermediate, posterior or panuveitis, depending on the part of eye affected by the inflammatory process. In children, noninfectious, chronic uveitis is a relatively uncommon but serious disease, with the potential for significant long-term complications and possible blindness. Read More

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http://dx.doi.org/10.1517/13543784.2012.636350DOI Listing
January 2012
5 Reads

Childhood chronic anterior uveitis associated with vernal keratoconjunctivitis (VKC): successful treatment with topical tacrolimus. Case series.

Pediatr Rheumatol Online J 2011 Nov 2;9(1):34. Epub 2011 Nov 2.

Institute for Maternal and Child Health - IRCCS "Burlo Garofolo" - Trieste and University of Trieste, Via dell'Istria 65/1, 34100, Trieste, Italy.

Uveitis treatment involves topical corticosteroids along with cycloplegic-mydriatics. Particularly severe cases may require systemic corticosteroids and immunosuppressive drugs. Vernal keratoconjunctivitis (VKC) treatment consists of a brief period of topical corticosteroids and/or cyclosporine. Read More

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http://dx.doi.org/10.1186/1546-0096-9-34DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221618PMC
November 2011
13 Reads

Juvenile idiopathic arthritis - an update on pharmacotherapy.

Authors:
Philip Kahn

Bull NYU Hosp Jt Dis 2011 ;69(3):264-76

New York University School of Medicine, NYU Langone Medical Center, New York, New York, USA.

Juvenile idiopathic arthritis (JIA) consists of a collection of all forms of chronic arthritis in childhood with no apparent cause. JIA is the most common rheumatic disease in children and may result in significant pain, joint deformity, and growth impairment, with persistence of active arthritis into adulthood. The extra-articular features of JIA, such as anterior uveitis or macrophage activation syndrome, are often the greater focus of therapy. Read More

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February 2012
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Patterns of childhood-onset uveitis in a referral center in Turkey.

J Ophthalmic Inflamm Infect 2012 Mar 16;2(1):13-9. Epub 2011 Oct 16.

Ulucanlar Eye Hospital, Ankara, Turkey,

Purpose: This study aimed to investigate the frequency and characteristics of childhood-onset uveitis and evaluate the rate and specific causes of visual loss in this population.

Methods: The data of 121 patients (179 eyes) with uveitis starting before ≤16 years and followed up for at least 6 months were retrospectively evaluated. Age at onset, sex, laterality, associated systemic disease, laboratory data, therapeutic strategies, surgeries, final visual acuity, and causes leading to visual acuity ≤20/200 were analyzed. Read More

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http://dx.doi.org/10.1007/s12348-011-0044-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3303000PMC
March 2012
1 Read

[Epidemiologic study of pediatric uveitis: a series of 49 cases].

J Fr Ophtalmol 2012 Jan 1;35(1):30-4. Epub 2011 Sep 1.

Institut Hédi-Rais d'Ophtalmologie (Service B), boulevard 9-Avril, 1006 Bab Saadoun, Tunis, Tunisie.

Purpose: To analyze the patterns of pediatric uveitis.

Patients And Methods: A retrospective study of 49 children with uveitis, examined from January 2000 to December 2009. All patients underwent a complete ophthalmic examination and an etiological search; follow-up varied from six months to seven years. Read More

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http://dx.doi.org/10.1016/j.jfo.2011.02.019DOI Listing
January 2012
2 Reads

[Diffuse anterior retinoblastoma].

Ophthalmologe 2011 Oct;108(10):969-72

Emory Eye Center, L.F. Montgomery Laboratory, Emory University, BT 428, 1365 Clifton Road NE, Atlanta, Georgia 30322, USA.

Retinoblastoma is the most common primary intraocular tumor in childhood. Diffuse anterior retinoblastoma is an uncommon variant and usually occurs in comparatively older children. Typically, there is an extensive infiltration of the anterior segment by tumor cells clinically mimicking anterior uveitis with pseudohypopyon. Read More

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http://dx.doi.org/10.1007/s00347-011-2369-yDOI Listing
October 2011

Behçet disease in children.

Ocul Immunol Inflamm 2011 Apr;19(2):103-7

Department Ophthalmology, Ankara University Medical School, Ankara, Turkey.

Purpose: To investigate the incidence and clinical characteristics of Behçet disease in children.

Methods: The authors retrospectively reviewed the charts of 3382 patients with Behçet disease from October 1986 to December 2005 at Ankara University Medical School Behçet Unit and/or Atmaca private clinic.

Results: 110 children were diagnosed with Behçet disease. Read More

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http://dx.doi.org/10.3109/09273948.2011.555592DOI Listing
April 2011
4 Reads

Abatacept: a potential therapy in refractory cases of juvenile idiopathic arthritis-associated uveitis.

Graefes Arch Clin Exp Ophthalmol 2011 Feb 5;249(2):297-300. Epub 2010 Oct 5.

St Paul's Eye Unit, Royal Liverpool University Hospital, Prescot Street, Liverpool, L7 8XP, UK.

Background: Juvenile idiopathic arthritis (JIA) is the most common of all systemic conditions associated with childhood uveitis. Visual impairment has been shown to be as high as 40% of which 10% being blind (6/60 or worse). Due to the lack of well-designed randomized control trials for paediatric uveitis and arthritis there are limited comparative data regarding the efficacy of single or combination treatments. Read More

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http://dx.doi.org/10.1007/s00417-010-1523-6DOI Listing
February 2011
4 Reads

[A case of frosted branch angiitis associated with retinal vein occlusion as a complication of familial Mediterranean fever].

Nippon Ganka Gakkai Zasshi 2010 Jul;114(7):621-8

Department Ophthalmology, Odate Municipal Hospital, 3-1 Yutakacho, Odate-shi 017-8550, Japan.

Background: Familial Mediterranean fever (FMF) is characterized by recurrent episodes of fever and serositis caused by autosomal recessive inheritance MEFV gene mutations. It is reported that the onset of angiitis is high among patients with this disease, but no reports were found in the field of ophthalmology in Japan. In this paper, we report one case that developed from optic disc vasculitis to frosted branch angiitis associated with retinal vein occlusion. Read More

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July 2010
2 Reads

Burden of childhood-onset arthritis.

Pediatr Rheumatol Online J 2010 Jul 8;8:20. Epub 2010 Jul 8.

Robert Wood Johnson Medical School-UMDNJ, Dept, of Pediatrics Room 1361, 89 French Street, New Brunswick, NJ, USA.

Juvenile arthritis comprises a variety of chronic inflammatory diseases causing erosive arthritis in children, often progressing to disability. These children experience functional impairment due to joint and back pain, heel pain, swelling of joints and morning stiffness, contractures, pain, and anterior uveitis leading to blindness. As children who have juvenile arthritis reach adulthood, they face possible continuing disease activity, medication-associated morbidity, and life-long disability and risk for emotional and social dysfunction. Read More

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http://dx.doi.org/10.1186/1546-0096-8-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914068PMC
July 2010
2 Reads

Familial case of Blau syndrome associated with a CARD15/NOD2 mutation.

Ophthalmic Genet 2010 Sep;31(3):155-8

Asociación para Evitar la Ceguera en México, Genetics, México City, Mexico.

Purpose: Blau syndrome is a rare autosomal dominant disorder characterized by early onset granulomatous arthritis, uveitis, skin rash and camptodactyly. We report a familial case of Blau syndrome associated with a CARD15/NOD2 mutation.

Methods: PCR amplification and automated DNA sequencing of the complete CARD15/NOD2 coding sequence was performed. Read More

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http://dx.doi.org/10.3109/13816810.2010.492818DOI Listing
September 2010
2 Reads

Current therapeutic approaches to autoimmune chronic uveitis in children.

Autoimmun Rev 2010 Aug 26;9(10):674-83. Epub 2010 May 26.

Department of Paediatrics, Anna Meyer Children's Hospital, University of Florence, Italy.

Uveitis is an inflammatory disorder involving inflammation of the uveal tract. It is classified as anterior, intermediate, posterior or panuveitis, depending on the part of eye affected by the inflammatory process. In children, non-infectious, chronic uveitis is a relatively uncommon but serious disease, with the potential for significant long-term complications and possible blindness. Read More

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http://dx.doi.org/10.1016/j.autrev.2010.05.017DOI Listing
August 2010
1 Read

[Recurrent uveitis of unknown origin in childhood].

Ophthalmologe 2010 Dec;107(12):1156-9

Augenklinik der Ludwig-Maximilians-Universität München, Mathildenstraße 8, Munich, Germany.

This report describes a 12-year-old girl with diffuse infiltrating retinoblastoma. This inflammatory condition belongs to the uveitis masquerade syndromes, which comprise a group of various ocular diseases such as chronic intraocular inflammation and ocular tumors. Read More

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http://link.springer.com/10.1007/s00347-010-2194-8
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http://dx.doi.org/10.1007/s00347-010-2194-8DOI Listing
December 2010
2 Reads