983 results match your criteria Uterus Smooth Muscle Tumors


Educational Case: Smooth Muscle Tumors of the Uterus.

Acad Pathol 2020 Jan-Dec;7:2374289520932285. Epub 2020 Jun 19.

Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, USA.

http://journals.sagepub.com/doi/10. Read More

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http://dx.doi.org/10.1177/2374289520932285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307400PMC

Inflammatory Myofibroblastic Tumor of the Uterus: An Immunohistochemical Study of 23 Cases.

Am J Surg Pathol 2020 Jun 19. Epub 2020 Jun 19.

Massachusetts General Hospital, Boston, MA.

Inflammatory myofibroblastic tumors (IMT) of the uterus may be underrecognized as their morphology and immunophenotype may overlap with myxoid variants of uterine smooth muscle tumors and endometrial stromal tumors. Although ALK is a helpful biomarker, not all uterine IMTs are ALK-rearranged, and a small subset of myxoid leiomyosarcomas is ALK-positive. Herein, we evaluated a series of 23 IMTs for the novel endometrial stromal markers interferon-inducible transmembrane protein-1 (IFITM1) and BCOR, the novel myoid marker transgelin, and possible predictive markers p16 and p53 by immunohistochemistry to determine their expression profile and potential prognostic value. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001525DOI Listing

Uterine PEComa with aggressive behavior: A review with an additional case of spontaneous vaginal expulsion.

Pathol Res Pract 2020 Jun 4;216(6):152991. Epub 2020 May 4.

Pathology Unit, Service Department, ULSS9 "Scaligera", Verona, Italy. Electronic address:

Perivascular epithelioid cell tumor (PEComa) is a rare mesenchymal tumor originating from perivascular epitheloid cells showing melanocytic and smooth muscle differentiation. The uterus represents the second most common site of origin. A 49 years woman presented to our Hospital for a vaginal spontaneous expulsion of a mass suggestive for malignant mesenchymal tumor. Read More

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http://dx.doi.org/10.1016/j.prp.2020.152991DOI Listing

Ultrasound and clinical characteristics of uterine smooth muscle tumors of uncertain malignant potential (STUMPs).

Eur J Obstet Gynecol Reprod Biol 2020 May 25;251:167-172. Epub 2020 May 25.

Department of Surgical Science, Università Degli Studi Di Torino, Italy.

Objective(s): Smooth muscle tumors of uncertain malignant potential are rare uterine neoplasms. Their identification through imaging is still limited due to the few available descriptions in the scientific literature. The objective of this paper is to provide clinical and ultrasound features that could support an early identification of these neoplasms. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.05.040DOI Listing

Abdominal Wall Leiomyoma: A Case Report.

J Reprod Infertil 2020 Apr-Jun;21(2):151-154

- Department of Obstetrics and Gynecology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Fibroma or leiomyoma is the most common benign tumor of the female reproductive system, which is usually found in the uterus, but may also occur in other places, such as the ovary, the broad ligament, and in rare cases in the abdominal wall. The formation of the abdominal wall leiomyoma may result from the implantation of myometrium tissue following surgical removal of the uterine leiomyoma, but sometimes these masses occur in a person who has no history of myomectomy.

Case Presentation: This case was a patient who became a candidate for laparoscopy due to abnormal uterine bleeding and pain in the right upper quadrant of the abdomen and ovarian mass. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253935PMC

Scrotal leiomyoma a rare benign intra-scrotal mass could lead to unnecessary orchiectomy.

Urol Case Rep 2020 Sep 12;32:101170. Epub 2020 Apr 12.

Fasa University of Medical Sciences, Urology Department, Iran.

Leiomyoma is a benign tumor originating from smooth muscle cell, Mostly from uterus. However, in men is a very rare entity. Scrotal leiomyoma is a very rare tumor. Read More

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http://dx.doi.org/10.1016/j.eucr.2020.101170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184519PMC
September 2020

Efficacy assessment of acupuncture in improving symptoms of uterine fibroids: A randomized controlled trial.

Medicine (Baltimore) 2020 May;99(18):e20016

Fujian University of Traditional Chinese Medicine Subsidiary Rehabilitation Hospital, Fuzhou 350013, China.

Introduction: Uterine fibroids are a common benign genital tumor disease in gynecological diseases. It is mainly a change in physical function caused by the growth of smooth muscle cells in the factor uterus. Modern medicine's treatment of this disease is based on the dependence of uterine fibroids on sex hormones. Read More

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http://dx.doi.org/10.1097/MD.0000000000020016DOI Listing

Smooth muscle tumor of uncertain malignant potential (STUMP): a clinicopathologic analysis of 26 cases.

Int J Clin Exp Pathol 2020 1;13(4):818-826. Epub 2020 Apr 1.

Department of Pathology, Mindong Hospital of Fujian Medical University Fu'an, Fujian, China.

Background: To investigate the clinicopathologic features, differential diagnosis, and factors associated with recurrence in patients with smooth muscle tumors of uncertain malignant potential (STUMP).

Methods: The clinical and pathologic data of STUMP patients diagnosed in Mindong Hospital of Ningde City from 2017 to 2018 were collected and slides reviewed, the high-frequency color Doppler ultrasound and pathological characteristics were observed, and the literature was reviewed.

Results: All the STUMP diagnoses were confirmed by slide review. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191150PMC

The Role of miRNA and Related Pathways in Pathophysiology of Uterine Fibroids-From Bench to Bedside.

Int J Mol Sci 2020 Apr 24;21(8). Epub 2020 Apr 24.

Department of Gynecological Oncology and Gynecology, Medical University of Lublin, 20-081 Lublin, Poland.

Uterine fibroids (UFs) are the most common benign tumors of the female genital tract. Their prevalence usually is estimated at 30-40%, but may reach up to 70-80% in predisposed groups of women. UFs may cause various clinical issues which might constitute the major reason of the overall deterioration of the quality of life. Read More

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http://dx.doi.org/10.3390/ijms21083016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216240PMC

Multiple STUMPs in a 19-year-old woman: a rare case report.

Hippokratia 2019 Apr-Jun;23(2):96

Third Department of Obstetrics and Gynecology, Faculty of Medicine, Aristotle University of Thessaloniki, Greece.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7127922PMC

Primary intracranial intraventricular leiomyoma: a literature review.

Neurosurg Rev 2020 Mar 30. Epub 2020 Mar 30.

Department of Neurosurgery, Yeditepe University Kosuyolu Hospital, Yeditepe University School of Medicine, Koşuyolu Mahallesi, Koşuyolu Cad. No: 168, 34718, Kadıköy/İstanbul, Turkey.

Leiomyomas, benign tumors of well-differentiated smooth muscle and vascular collagenous tissue, usually occur in the uterus but can develop wherever smooth muscle is present. Primary intracranial leiomyomas are rare tumors. We present the case of a 40-year-old woman with a primary intraventricular leiomyoma. Read More

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http://dx.doi.org/10.1007/s10143-020-01291-6DOI Listing

Leiomyoma of the Cheek.

Case Rep Pathol 2020 19;2020:8474905. Epub 2020 Feb 19.

Department of Oral Pathology, Barros Barreto Hospital, Belém, PA, Brazil.

Leiomyomas are rare benign tumors that grow in the tunica media of smooth muscle cells. Leiomyomas occur most frequently in the uterus or gastrointestinal tract and only very rarely in the area of the cheek. This study reports on a rare case of a leiomyoma in the cheek of a 43-year-old woman, who presented with a well-circumscribed, asymptomatic, mobile swelling in the right cheek. Read More

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http://dx.doi.org/10.1155/2020/8474905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7053474PMC
February 2020

Disseminated peritoneal leiomyomatosis: an unusual presentation of intra-abdominal lesion mimicking disseminated malignancy.

Med Pharm Rep 2020 Jan 31;93(1):113-116. Epub 2020 Jan 31.

Department of Radiation Oncology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Leiomyoma are commonly seen as benign smooth muscle tumors of the uterus. Smooth muscle tumors with unusual growth pattern are rare and include 3 primary neoplasms: intravenous leiomyomatosis (IVL), benign metastasizing leiomyoma (BML) and disseminated peritoneal leiomyomatosis (DPL). DPL is a rare benign disease, often giving the appearance of metastatic ovarian or peritoneal carcinoma. Read More

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http://dx.doi.org/10.15386/mpr-1421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051819PMC
January 2020

Unexpected uterine smooth muscle tumor of uncertain malignant potential and sarcoma: A single center cohort study in South Korea.

Taiwan J Obstet Gynecol 2020 Mar;59(2):275-281

Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University College of Medicine, Seoul, Republic of Korea.

Objective: To evaluate the risk of encountering unexpected uterine smooth muscle tumors of uncertain malignant potential (STUMPs) or sarcomas during surgical treatment of mesenchymal tumors of the uterus using morcellation.

Material And Methods: Data were collected retrospectively from subjects who were pathologically diagnosed with uterine leiomyoma or its variants, STUMP or other premalignant mesenchymal tumors of uterus, or sarcoma during surgical treatment between July 2014 and June 2017.

Results: A total of 3785 women were investigated; 2824 laparoscopic procedures (74. Read More

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http://dx.doi.org/10.1016/j.tjog.2020.01.017DOI Listing

Uterine tumor resembling ovarian sex cord tumor: A series of six cases displaying varied histopathological patterns and clinical profiles.

Indian J Pathol Microbiol 2020 Feb;63(Supplement):S81-S86

Department of Pathology, All India Institute of Medical Sciences, New Delhi, India.

Introduction: Uterine tumors resembling ovarian sex cord tumor (UTROSCT) are a unique group of neoplasms with diverse morphology and immunophenotypic characteristics, coexpressing sex cord, epithelial, and smooth-muscle markers. To date, less than 100 cases have been reported and there is paucity of data concerning their clinical behavior.

Materials And Methods: All cases of uterine body tumors diagnosed over a period of two and a half years (2016-2018) were retrieved. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_340_19DOI Listing
February 2020

[Metastatic leiomyoma or synchronous lesion of the uteri corpus and vulva?]

Arkh Patol 2020 ;82(1):62-67

Moscow Regional Research Institute of Obstetrics and Gynecology, Moscow, Russia.

Objective: To reveal the morphological characteristics of simultaneously diagnosed leiomyoma of the corpus uteri and vulva.

Subject And Methods: The paper describes a case of multiple uterine leiomyomas concurrent with vulvar leiomyoma in a 39-year-old patient with progressive tumor nodule growth over 2 years. Vulvar tumor was biopsied simultaneously with extirpation of the uterus; vulvar leiomyoma was removed six months later. Read More

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http://dx.doi.org/10.17116/patol20208201162DOI Listing
February 2020

Paeonol alleviates primary dysmenorrhea in mice via activating CB2R in the uterus.

Phytomedicine 2020 Mar 16;68:153151. Epub 2019 Dec 16.

Department of Pharmacy, Nanjing University of Chinese Medicine Affiliated Hospital, Nanjing, Jiangsu 210029, China. Electronic address:

Background And Purpose: Primary dysmenorrhea is the most common gynaecologic problem in menstruating women and is characterized by spasmodic uterine contraction and pain symptoms associated with inflammatory disturbances. Paeonol is an active phytochemical component that has shown anti-inflammatory and analgesic effects in several animal models. The aim of this study was to explore whether paeonol is effective against dysmenorrhea and to investigate the potential mechanism of cannabinoid receptor signalling. Read More

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http://dx.doi.org/10.1016/j.phymed.2019.153151DOI Listing

An Unusual Presentation of Vaginal Leiomyoma.

J Midlife Health 2019 Oct-Dec;10(4):204-205

Department of Obstetrics and Gynecology, NKP Salve Institute of Medical Sciences, Nagpur, Maharashtra, India.

Leiomyomas are classified as benign mesenchymal neoplasms and consist of smooth muscle cells with variable amounts of fibrous stroma. The tumors occur most frequently in the uterus, affecting 20%-30% of women of reproductive age, but vaginal leiomyomas are rare with only around 300 cases reported since the first case was described in 1733. These tumors are thought to arise from Müllerian smooth muscle cells in the subepithelium of the vagina. Read More

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http://dx.doi.org/10.4103/jmh.JMH_40_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6947721PMC
January 2020

Uterine pleomorphic leiomyosarcoma with osteoclastic giant cells: Case report with peritoneal washing cytology and cell block study.

Rev Esp Patol 2020 Jan - Mar;53(1):61-65. Epub 2018 Jul 26.

Department of Pathology, Hospital Universitario Dr. Peset, Valencia, Spain.

Uterine leiomyosarcoma (LMS) with osteoclastic giant cells (OGCs) is extremely rare. However, its morphological appearance and aggressive behavior may have resulted in its being diagnosed as so-called giant cell malignant fibrous histiocytoma (MFH) in the past. Effusions are not uncommon in LMS and may be indicative of an unfavorable prognosis. Read More

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http://dx.doi.org/10.1016/j.patol.2018.06.002DOI Listing

Reasons to Reconsider Risk Associated With Power Morcellation of Uterine Fibroids.

In Vivo 2020 Jan-Feb;34(1):1-9

Institute of Medical Genetics, University Rostock Medical Center, Rostock, Germany

Our insights into the molecular pathogenesis of uterine smooth muscle tumors have improved significantly. Accordingly, in the present review, we advocate a more refined risk assessment for patients considering surgical removal of fibroids or hysterectomy, respectively, requiring morcellation. For this procedure, the risk estimates given for the iatrogenic spread of a previously unexpected malignancy considerably vary among different studies. Read More

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http://dx.doi.org/10.21873/invivo.11739DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984091PMC

From 2646 to 15: differentially regulated microRNAs between progenitors from normal myometrium and leiomyoma.

Am J Obstet Gynecol 2020 06 24;222(6):596.e1-596.e9. Epub 2019 Dec 24.

Department of Clinical and Molecular Sciences-Histology, Università Politecnica delle Marche, Ancona, Italy.

Background: Uterine leiomyomas (fibroids) are smooth muscle neoplasms of the myometrial layer of the uterus and are the most common benign tumors in women. Although their etiology is still unclear, progenitor cells seem to be implicated.

Objective: To identify the dysregulated pathways involved in leiomyoma onset by microRNA profiling of progenitor cells isolated from normal myometrium and leiomyoma tissue. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.12.016DOI Listing

Inflammatory myofibroblastic tumor of the uterus - case report.

Cesk Patol 2019 ;55(4):239-243

Inflammatory myofibroblastic tumor (IMT) of the uterus is rare but probably underdiagnosed tumor. It is usually benign but small fraction of cases may locally recur or rarely metastasize. Herein, we present a case report of 66-year-old patient with uterine IMT originally diagnosed as leiomyosarcoma of the uterus. Read More

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January 2020

Intravascular Leiomyomatosis Extending to Right Atrium: A Rare Caused Syncope.

Ann Vasc Surg 2020 May 16;65:287.e7-287.e10. Epub 2019 Nov 16.

Department of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, People's Republic of China. Electronic address:

Intravascular leiomyomatosis (IVL) is a variant of leiomyoma characterized by intravascular proliferation of a histologically benign smooth muscle tumor extending beyond the uterus into distant great vessels or the heart. It is a rare disease and results in death. Here, we reported the case of 48-year-old, otherwise well woman, who presented to the emergency department with syncope. Read More

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http://dx.doi.org/10.1016/j.avsg.2019.11.024DOI Listing

False positive in fluorodeoxyglucose-F18 positron emission tomography computed tomography scan of inferior vena cava leiomyoma in patient with a suspected paraganglioma.

Rev Esp Med Nucl Imagen Mol 2020 Jan - Feb;39(1):27-30. Epub 2019 Nov 15.

Servicio de Medicina Nuclear, Hospital Universitario Virgen de las Nieves, Granada, España.

Leiomyomas are benign tumors derived from smooth muscle tissue that rarely present outside the uterus. These tumors do not usually show FDG uptake. We present the case of a patient with hypertension refractory to treatment and a lesion arising from inferior vena cava, that shows intense FDG uptake in PET/CT scan, suggestive of paraganglioma, with a final histological diagnosis of leiomyoma. Read More

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http://dx.doi.org/10.1016/j.remn.2019.06.006DOI Listing
November 2019

Melatonin activates cell death programs for the suppression of uterine leiomyoma cell proliferation.

J Pineal Res 2020 Jan 28;68(1):e12620. Epub 2019 Nov 28.

School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan.

The circadian nature of melatonin has a protective effect on the progression of female reproductive cancers, including breast and ovarian cancers. However, the effect of melatonin on the growth of uterine leiomyoma is still unclear. In this study, we found that the growth of uterine leiomyoma ELT3 cells was reduced by treatment with melatonin. Read More

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http://dx.doi.org/10.1111/jpi.12620DOI Listing
January 2020

Leiomyoma phosphoproteins involved in inhibition of oxidative stress and synthesis of reactive oxygen species.

Int J Mol Med 2019 Dec 21;44(6):2329-2335. Epub 2019 Oct 21.

Institute for Maternal and Child Health‑IRCCS 'Burlo Garofolo', I‑34137 Trieste, Italy.

Uterine leiomyomas are benign smooth muscle cell tumors originating from the myometrium. The present study focused on leiomyoma and myometrium phosphoproteome enrichment by using immobilized metal affinity chromatography (IMAC). The phosphoproteome was analyzed by two‑dimensional gel electrophoresis coupled with mass spectrometry. Read More

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http://dx.doi.org/10.3892/ijmm.2019.4377DOI Listing
December 2019
1 Read
1.880 Impact Factor

Stromal p16 Expression Helps Distinguish Atypical Polypoid Adenomyoma From Myoinvasive Endometrioid Carcinoma of the Uterus.

Am J Surg Pathol 2019 11;43(11):1526-1535

Departments of Pathology.

Atypical polypoid adenomyoma (APA) is a polypoid lesion that is comprised of atypical endometrial glands and fibromuscular stroma, which pathologists often confuse with myoinvasive endometrioid carcinoma. Here, we characterized the immunohistochemical and molecular features of the stromal components of APA to find distinct markers between APA and myoinvasive endometrioid carcinoma. First, we examined the immunohistochemical expression and gene mutations that were previously investigated in uterine and breast fibroepithelial lesions using 12 cases of APA. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001320DOI Listing
November 2019
1 Read

Low-Grade Vaginal Endometrial Stromal Sarcoma: An Extremely Rare Case Report and Review of the Literature.

Int J Gynecol Pathol 2019 Sep 27. Epub 2019 Sep 27.

Departments of Pathology (Y.T., Y.C., J.C., P.Y., Q.C., L.Z., L.L.) Gynaecology and Obstetrics (L.T., D.Z.), Chengdu Third People's Hospital, Sichuan, China.

Endometrial stromal sarcoma (ESS) is a rare malignant tumor of the uterus that has been described as the second most common malignant uterine mesenchymal tumor. The Primary extrauterine ESS (EESS) is an extremely uncommon occurrence. We hereby report a new bona fide case of low-grade EESS in a 74-yr-old woman arising in the vagina, presenting as a polypoid mass associated with irregular vaginal bleeding. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000626DOI Listing
September 2019
3 Reads

Exon 1 Mutational Screening in Iranian Patients with Uterine Leiomyoma.

Rep Biochem Mol Biol 2019 Apr;8(1):21-24

Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Uterine leiomyoma, also called fibroid, is a benign tumor that arises due to monoclonal transformation of myometrium, the smooth muscle cell layer of the uterus. Fibroids cause several complications including infertility, miscarriage, bleeding, pain, and dysmenorrhea. Recent studies have revealed the role of mutations in gene exon 2 in various populations; however, the reported frequency of these mutations differs between reports. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6590935PMC
April 2019
5 Reads

The Expression of MBD6 Is Associated with Tumor Size in Uterine Leiomyomas.

Genet Test Mol Biomarkers 2019 Aug 16;23(8):523-532. Epub 2019 Jul 16.

1Medical College of Nanchang University, Nanchang, Jiangxi, P.R. China.

Uterine leiomyoma (UL) is the most common benign smooth muscle tumor of the uterus in reproductive women. Prior studies indicated that methyl-CpG-binding domain proteins (MBDs) may be involved in the pathogenesis of UL. In this study, UL tissues and paired adjacent myometrium were collected from a total of 51 patients. Read More

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http://dx.doi.org/10.1089/gtmb.2019.0070DOI Listing
August 2019
4 Reads

Progesterone receptor antagonist provides palliative effects for uterine leiomyoma through a Bcl-2/Beclin1-dependent mechanism.

Biosci Rep 2019 07 23;39(7). Epub 2019 Jul 23.

Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China

Uterine leiomyoma is the most common benign smooth muscle tumor of uterus in women of reproductive age, with a high lifetime incidence. Nowadays, the exploration on the pharmacotherapies, such as progesterone receptor antagonist (PRA) requires more attention. Hence, the current study aimed to examine whether mifepristone, a PRA, influences the autophagy and apoptosis of uterine leiomyoma cells. Read More

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http://dx.doi.org/10.1042/BSR20190094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6646233PMC
July 2019
6 Reads

Toll-like receptor 4 contributes to uterine activation by upregulating pro-inflammatory cytokine and CAP expression via the NF-κB/P38MAPK signaling pathway during pregnancy.

J Cell Physiol 2020 Jan 24;235(1):513-525. Epub 2019 Jun 24.

Department of Laboratory Medicine, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Evidence indicates that inflammatory response is significant during the physiological process of human parturition; however, the specific signaling pathway that triggers inflammation is undefined. Toll-like receptors (TLRs) are key upstream gatekeepers that control inflammatory activation before preterm delivery. Our previous study showed that TLR4 expression was significantly increased in human pregnancy tissue during preterm and term labor. Read More

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http://dx.doi.org/10.1002/jcp.28991DOI Listing
January 2020
6 Reads

Myxoid smooth muscle neoplasia of the uterus: comprehensive analysis by next-generation sequencing and nucleic acid hybridization.

Mod Pathol 2019 11 12;32(11):1688-1697. Epub 2019 Jun 12.

Department of Laboratory Medicine and Molecular Diagnostics, Sunnybrook Health Sciences Centre and University of Toronto, Toronto, ON, Canada.

Uterine myxoid smooth muscle tumors, including myxoid leiomyosarcoma, are rare and their genomic profile has not been fully characterized. With the discovery of uterine sarcomas with ZC3H7B-BCOR fusion and BCOR internal tandem duplications, the differential diagnosis of myxoid smooth muscle lesions is expanding to include molecularly-defined tumors. Thus, we aimed to explore the genomic landscape of myxoid smooth muscle tumor using comprehensive tools. Read More

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http://dx.doi.org/10.1038/s41379-019-0299-4DOI Listing
November 2019
10 Reads

Detailed Morphologic and Immunohistochemical Characterization of Myomectomy and Hysterectomy Specimens From Women With Hereditary Leiomyomatosis and Renal Cell Carcinoma Syndrome (HLRCC).

Am J Surg Pathol 2019 09;43(9):1170-1179

Department of Pathology, University of California San Francisco.

Hereditary leiomyomatosis and renal cell carcinoma syndrome (HLRCC), caused by a germline mutation in the fumarate hydratase (FH) gene, predisposes patients to uterine and cutaneous smooth muscle tumors and an aggressive type of renal cell carcinoma. Almost all women with HLRCC develop symptomatic uterine leiomyomas resulting in surgery at young ages, presenting an ideal opportunity for early detection of these patients and the implementation of surveillance measures for renal cell carcinoma. FH-deficient uterine leiomyomas can show characteristic morphologic features (FH-d morphology) that have been previously described. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001293DOI Listing
September 2019
15 Reads

α11β1 Integrin is Induced in a Subset of Cancer-Associated Fibroblasts in Desmoplastic Tumor Stroma and Mediates In Vitro Cell Migration.

Cancers (Basel) 2019 Jun 1;11(6). Epub 2019 Jun 1.

Department of Biomedicine and Centre for Cancer Biomarkers, University of Bergen, Jonas Lies vei 91, NO-5009 Bergen, Norway.

Integrin α11β1 is a collagen receptor that has been reported to be overexpressed in the stroma of non-small cell lung cancer (NSCLC) and of head and neck squamous cell carcinoma (HNSCC). In the current study, we further analyzed integrin α11 expression in 14 tumor types by screening a tumor tissue array while using mAb 203E3, a newly developed monoclonal antibody to human α11. Different degrees of expression of integrin α11 were observed in the stroma of breast, ovary, skin, lung, uterus, stomach, and pancreatic ductal adenocarcinoma (PDAC) tumors. Read More

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https://www.mdpi.com/2072-6694/11/6/765
Publisher Site
http://dx.doi.org/10.3390/cancers11060765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6627481PMC
June 2019
20 Reads

Synchronous Well-differentiated Endometrioid Adenocarcinoma and Leiomyosarcoma of the Uterus With Pulmonary Metastasis in a 50-Yr-Old Woman: A Case Report and Review of Literature.

Int J Gynecol Pathol 2020 Jul;39(4):373-378

Center for Essential Surgical and Acute Care, Global Health Directorate, Indus Health Network, (A.A.) Department of Pathology and Laboratory Medicine, Aga Khan University Hospital (N.U.D., N.K.), Karachi, Pakistan.

The most common synchronous gynecologic malignancies are endometrial and ovarian cancers. However, synchronous endometrial adenocarcinoma and uterine leiomyosarcoma are extremely rare. We report the case of a 50-yr-old woman who was diagnosed with concomitant endometrial adenocarcinoma and uterine leiomyosarcoma. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000611DOI Listing
July 2020
13 Reads

Smooth Muscle Tumors of the Female Genital Tract.

Surg Pathol Clin 2019 Jun;12(2):397-455

Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First Street, Southwest, Rochester, MN 55905, USA. Electronic address:

Smooth muscle tumors are the most common mesenchymal tumors of the female genital tract. However, awareness of tumor variants and unconventional growth patterns is critical for appropriate classification and patient management. For example, recognition of fumarate hydratase-deficient leiomyomas allows pathologists to alert providers to the potential for hereditary leiomyomatosis and renal cell carcinoma. Read More

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http://dx.doi.org/10.1016/j.path.2019.02.004DOI Listing
June 2019
6 Reads

Uterine Mesenchymal Tumors: Update on Classification, Staging, and Molecular Features.

Surg Pathol Clin 2019 Jun;12(2):363-396

Department of Pathology, Stanford University, Stanford University School of Medicine, 300 Pasteur Drive H2128E, Stanford, CA 94305-5324, USA.

The spectrum of mesenchymal neoplasia in the uterus has expanded in recent years. First, the identification of prevalent, recurrent molecular alterations has led to a more biologically and clinically congruent classification of endometrial stromal tumors. Likewise, the diagnostic criteria of several rare and miscellaneous tumor types have been refined in recent case series (Perivascular Epithelioid Cell tumor, inflammatory myofibroblastic tumor). Read More

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http://dx.doi.org/10.1016/j.path.2019.01.004DOI Listing
June 2019
9 Reads

Ultrasound Features of Uterine Sarcomas.

Ultrasound Q 2019 Dec;35(4):376-384

Department of Radiology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, 102, Seoul, Korea.

Uterine sarcomas include leiomyosarcoma, smooth muscle tumor of uncertain malignant potential, endometrial stromal sarcoma, undifferentiated sarcoma, carcinosarcoma, adenosarcoma, and rhabdomyosarcoma. Leiomyosarcomas are the most common uterine sarcomas and list some potential others. Uterine sarcomas have a wide histopathological spectrum that may display various imaging features, making the preoperative diagnosis challenging. Read More

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http://dx.doi.org/10.1097/RUQ.0000000000000454DOI Listing
December 2019
2 Reads

[Uterine fibroid associated with smooth muscle tumor of uncertain malignant potential (STUMP): about a case].

Pan Afr Med J 2018 30;31:151. Epub 2018 Oct 30.

Service Gynécologie-Obstétrique I, CHU Hassan II, Fès, Maroc.

STUMP (smooth muscle tumor of uncertain malignant potential) are smooth muscle tumors that cannot be diagnosed as either benign or malignant due to their morphological characteristics. We here report the case of a 44 year old patient with no notable medical history presenting with an increase in the abdominal volume. Pelvic ultrasound and CT TAP scan were performed showing voluminous mass with tissue and fluid-filled component in the uterus. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.151.14135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488250PMC
May 2019
7 Reads

LncRNA MEG3 inhibits trophoblast invasion and trophoblast-mediated VSMC loss in uterine spiral artery remodeling.

Mol Reprod Dev 2019 06 8;86(6):686-695. Epub 2019 May 8.

Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Extravillous trophoblasts (EVTs) migrate into uterine decidua and induce vascular smooth muscle cell (VSMC) loss through mechanisms thought to involve migration and apoptosis, achieving complete spiral artery remodeling. Long noncoding RNA maternally expressed gene 3 (MEG3) can regulate diverse cellular processes, such as proliferation and migration, and has been discovered highly expressed in human placenta tissues. However, little is known about the role of MEG3 in modulating EVT functions and EVT-induced VSMC loss. Read More

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http://dx.doi.org/10.1002/mrd.23147DOI Listing
June 2019
3 Reads
2.527 Impact Factor

Pleomorphic Undifferentiated Uterine Sarcoma in a Young Patient Presenting With Elevated Beta-hCG and Rare Variants of Benign Leiomyoma: A Case Report and Review of the Literature.

Int J Gynecol Pathol 2020 Jul;39(4):362-366

Departments of Pathology (V.K., K.R.) Gynecology Oncology (P.S., D.P.), Hospital network of the University of Montreal (CHUM), Montreal, Quebec, Canada.

Leiomyosarcoma (LMS) is a malignant mesenchymal neoplasm showing smooth muscle differentiation. Uterine LMS is more frequent that nonuterine LMS, and represents 1% of all malignant neoplasms of the uterus. Pleomorphic undifferentiated uterine sarcoma is a rare entity, and is defined by high-grade sarcoma histology with loss of muscular markers. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000606DOI Listing
July 2020
11 Reads

Metastatic low-grade endometrial stromal sarcoma of uterus presenting as a primary pancreatic tumor: case presentation and literature review.

Diagn Pathol 2019 Apr 22;14(1):30. Epub 2019 Apr 22.

Department of Anatomical Pathology, Laboratory Medicine Program, University Health Network, Toronto General Hospital, 200 Elizabeth Street, 11th Floor, Eaton Wing, Toronto, Ontario, M5G 2C4, Canada.

Background: Metastatic tumors to the pancreas are uncommon, accounting for approximately 2% of pancreatic malignancies. The most common primary tumors to give rise to pancreatic metastases are carcinomas.

Case Presentation: A 50-year old female patient was investigated for a cause of abdominal discomfort. Read More

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http://dx.doi.org/10.1186/s13000-019-0807-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477712PMC
April 2019
28 Reads

Adlay ( L. var. Stapf.) Hull Extract and Active Compounds Inhibit Proliferation of Primary Human Leiomyoma Cells and Protect against Sexual Hormone-Induced Mice Smooth Muscle Hyperproliferation.

Molecules 2019 Apr 19;24(8). Epub 2019 Apr 19.

School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan.

Uterine leiomyomas, also known as fibroids, are benign neoplasms of the uterus and have a high incidence rate in women of reproductive age. Hysterectomy or myomectomy is the initial treatment, but fibroids will recur if the patient is still exposed to similar risk factors. Therefore, developing new therapeutic strategies are urgently necessary. Read More

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http://dx.doi.org/10.3390/molecules24081556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514562PMC
April 2019
6 Reads

Prostaglandin E receptors differentially regulate the output of proinflammatory cytokines in myometrial cells from term pregnant women.

Sheng Li Xue Bao 2019 Apr;71(2):248-260

Department of Physiology, Navy Military Medical University (Second Military Medical University), Shanghai 200433, China.

Prostaglandin (PG) E plays critical roles during pregnancy and parturition. Emerging evidence indicates that human labour is an inflammatory event. We sought to investigate the effect of PGE on the output of proinflammatory cytokines in cultured human uterine smooth muscle cells (HUSMCs) from term pregnant women and elucidate the role of subtypes of PGE receptors (EP, EP, EP and EP). Read More

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April 2019
6 Reads

Aberrant Hypermetabolism of Benign Uterine Leiomyoma on 18F-FDG PET/CT.

Clin Nucl Med 2019 Jun;44(6):e413-e414

Department of Gynecologic Oncology-Hospital Sírio-Libanês, São Paulo, Brazil.

Leiomyomas are prevalent benign smooth muscle tumors in the uterus, displaying variable degrees of FDG uptake on PET/CT. The glucose metabolism intensity of those lesions relies on biologic features and markedly increased FDG accumulation is more typically related to malignant diseases, as in the case of leiomyosarcomas. Notwithstanding that uterine fibroids typically exhibit mild to moderate FDG uptake, in this article we report a case of unexpectedly intense hypermetabolism of a benign uterine leiomyoma on a PET/CT scan performed for initial staging of a breast cancer patient. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002580DOI Listing
June 2019
20 Reads

Simultaneously occurring disseminated peritoneal leiomyomatosis and multiple extrauterine adenomyomas following hysterectomy.

Proc (Bayl Univ Med Cent) 2019 Jan 7;32(1):126-128. Epub 2019 Jan 7.

Division of Gynecologic Oncology, Department of Oncology, Baylor University Medical CenterDallasTexas.

Disseminated peritoneal leiomyomatosis (DPL), also known as leiomyomatosis peritonealis disseminata, is a rare condition characterized by multiple benign smooth muscle tumors proliferating along the peritoneal surfaces. In previous case reports, these tumors have been noted to involve the ovaries, round ligaments, bladder, bowel, peritoneum, and mesentery. To date, approximately 150 cases of DPL have been described in the literature. Read More

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https://www.tandfonline.com/doi/full/10.1080/08998280.2018.1
Publisher Site
http://dx.doi.org/10.1080/08998280.2018.1520555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442858PMC
January 2019
12 Reads

Clinicopathologic evaluation of uterine smooth muscle tumors of uncertain malignant potential (STUMP): A single center experience.

J Gynecol Obstet Hum Reprod 2019 Oct 18;48(8):637-642. Epub 2019 Mar 18.

Department of Gynecologic Oncology, University of Health Sciences Tepecik Education and Research Hospital, İzmir, Turkey.

Objective: To investigate the clinical outcomes and histopathological features of uterine smooth muscle tumors of uncertain malignant potential (STUMP).

Methods: The study analysed cases diagnosed with uterine STUMP in a tertiary center, between January 2003 and September 2018. We investigated the clinical, operative and histopatholologic data of the cases. Read More

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http://dx.doi.org/10.1016/j.jogoh.2019.03.003DOI Listing
October 2019
8 Reads

Uncommon Mixed Endometrial-Myometrial Benign Tumors of the Reproductive Tract: Literature Review.

Gynecol Obstet Invest 2019 19;84(6):521-547. Epub 2019 Mar 19.

Department of Gynecology, Obstetrics and Urology, Sapienza, University of Rome, Rome, Italy.

Background: We reviewed published cases of uterus-like mass (U-LM), endomyometriosis, polypoid adenomyoma (PA), adenomyomatous polyp, atypical PA (APA), and adenomyoma.

Search Methods: PubMed, Medline, and Scopus searches of all cases published in the databases till November 26, 2018.

Results: We identified 45 case reports of U-LM in the pelvis, 10 cases of endomyometriosis, 44 cases of adenomyomatous polyp, 466 cases of APA and case series of adenomyoma and PA. Read More

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http://dx.doi.org/10.1159/000499019DOI Listing
February 2020
9 Reads