146,160 results match your criteria Uterus Mullerian Duct Abnormalities
PLoS One 2018 6;13(12):e0206053. Epub 2018 Dec 6.
Department of Gynecological Endocrinology and Fertility Disorders, University of Heidelberg, Heidelberg, Germany.
Background: Local anesthetics (LAs) are increasingly used as therapeutics due to their multiple molecular effects. They may be potential agents also in gynecology and reproductive medicine. The objective of this study was to investigate the contractility response of the perfused swine uterus to different concentrations of the LAs procaine, lidocaine, and ropivacaine. Read More
Folia Med Cracov 2018 ;58(3):115-125
Department of Pathophysiology, Jagiellonian University Medical College, Czysta 18, Kraków, Poland.
Background: Anorexia nervosa is a widely prevalent eating disorder that o en leads to life-threatening complications. Since it mostly concerns females, many authors have focused on studying the reproductive system in anorexic women. Recently discovered telocytes may give a new insight into the pathophysiology of gynecological complications in these patients. Read More
Folia Med Cracov 2018 ;58(3):89-102
Department of Pathophysiology, Jagiellonian University Medical College, Kraków, Poland.
Introduction: Uterine leiomyoma is the most widespread benign tumor affecting women of childbearing age. ere are still gaps in the understanding of its pathogenesiss. Telocytes are unique cells described in greater than 50 different locations inside the human body. Read More
MMWR Morb Mortal Wkly Rep 2018 Dec 7;67(48):1333-1338. Epub 2018 Dec 7.
Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, CDC.
Uterine cancer is one of the few cancers with increasing incidence and mortality in the United States, reflecting, in part, increases in the prevalence of overweight and obesity since the 1980s (1). It is the fourth most common cancer diagnosed and the seventh most common cause of cancer death among U.S. Read More
FASEB J 2018 Dec 6:fj201802037R. Epub 2018 Dec 6.
Division of Animal Sciences, University of Missouri, Columbia, Missouri, USA.
The placenta plays a pivotal role in the development of the fetal brain and also influences maternal brain function, but our understanding of communication between the placenta and brain remains limited. Using a gene expression and network analysis approach, we provide evidence that the placenta transcriptome is tightly interconnected with the maternal brain and fetal brain in d 15 pregnant C57BL/6J mice. Activation of serotonergic synapse signaling and inhibition of neurotrophin signaling were identified as potential mediators of crosstalk between the placenta and maternal brain and fetal brain, respectively. Read More
Ann Med Surg (Lond) 2018 Dec 13;36:231-234. Epub 2018 Nov 13.
Department of Surgery, University Hospital Hairmyres, NHS Lanarkshire, East Kilbride, G75 8RG, Scotland, UK.
Introduction: Unexplained lactic acidosis (LA) in a critically ill patient often prompts investigations to rule out any reversible intra-abdominal cause. Equivocal results can lead to an emergency laparotomy (EL) with subsequent high morbidity and mortality rates. Our objective was to determine the clinical impact of urgent diagnostic laparoscopy (UDL) in such patients. Read More
Reprod Biol Endocrinol 2018 Dec 5;16(1):121. Epub 2018 Dec 5.
Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Ramat Gan, Israel.
Recurrent implantation failure (RIF) refers to cases in which women have had three failed in vitro fertilization (IVF) attempts with good quality embryos. The definition should also take advanced maternal age and embryo stage into consideration. The failure of embryo implantation can be a consequence of uterine, male, or embryo factors, or the specific type of IVF protocol. Read More
Environ Sci Technol 2018 Dec 5. Epub 2018 Dec 5.
Parabens have been of global concern due to their endocrine disrupting properties. However, few studies have reported tissue-specific distribution of parabens in wildlife. In this study, we measured parabens and their metabolites in organs and tissues (blubber, muscle, melon, stomach, kidney, liver, gonad, brain, uterus, and umbilical cord, total n=94) of common dolphins (Delphinus capensis) and finless porpoises (Neophocaena asiaeorientalis), to investigate tissue-specific accumulation and body burden. Read More
Int J Mol Sci 2018 Dec 4;19(12). Epub 2018 Dec 4.
First Department of Obstetrics and Gynecology, The Center of Postgraduate Medical Education, 01-004 Warsaw, Poland.
Uterine fibroids (UFs) are the most common benign tumors of the female genital tract. The incidence of UFs has been estimated at 25⁻80% depending on selected population. The pathophysiology of UFs remains poorly understood. Read More
J Gynecol Obstet Hum Reprod 2018 Nov 30. Epub 2018 Nov 30.
Département de Gynécologie Obstétrique, CHU Limoges, av Dominique Larrey, 87000 Limoges, France; INSERM, UMR-1248, CHU Limoges, 87000 Limoges, France. Electronic address:
J Anim Sci 2018 Dec 2. Epub 2018 Dec 2.
Department of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, 10-718 Olsztyn, Poland.
The aim of this study was to investigate the effect of orexin B (OXB) on progesterone (P4) and androstenedione (A4) secretion by porcine endometrial and myometrial tissue explants and on the expression of key steroidogenic proteins and enzymes involved in steroid production. The hormones secretion and the expression of steroidogenic acute regulatory protein (StAR), P450 side-chain cleavage enzyme (CYP11A1) and 3β-hydroxysteroid dehydrogenase (HSD3B1) was analyzed on days 10 to 11, 12 to 13, 15 to 16, 27 to 28 of pregnancy and during the luteal phase of the oestrous cycle (days 10 to 11). Endometrial and myometrial explants were cultured in vitro in the presence of OXB (1, 10 or 100 nM) and OXB (1, 10 or 100 nM) with 1 µM of JNJ (OX2R antagonist). Read More
Cell J 2019 Apr 18;21(1):49-56. Epub 2018 Nov 18.
The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran. Electronic
Objective: Fast Free-of-Acrylamide Clearing Tissue (FACT) is a recently developed protocol for the whole tissue three-dimensional (3D) imaging. The FACT protocol clears lipids using sodium dodecyl sulfate (SDS) to increase the penetration of light and reflection of fluorescent signals from the depth of cleared tissue. The aim of the present study was using FACT protocol in combination with imaging of auto-fluorescency of red blood cells in vessels to image the vasculature of a translucent mouse tissues. Read More
J Obstet Gynaecol Res 2018 Dec 2. Epub 2018 Dec 2.
2nd Unit of Obstetrics and Gynecology, Department of Biomedical Science and Human Oncology, University of Bari, Bari, Italy.
Aim: This retrospective multicenter study was carried out to evaluate feasibility, effectiveness and patient acceptability of a small diameter hysteroscopic tissue removal system in the treatment of large endometrial polyps (≥20 mm), usually not removed in an office setting.
Methods: Hundred and forty-six women with a single greater than 10-mm diameter polyp considered for polypectomy between April 2016 and August 2017. Sixty-five of these patients had a polyp size greater than 20 mm. Read More
Anaesthesia 2018 Dec 1. Epub 2018 Dec 1.
Department of Anaesthesia and Pain Management, Mount Sinai Hospital, University of Toronto, ON, Canada.
Postpartum haemorrhage is the leading cause of maternal mortality worldwide and prophylactic uterotonic drug administration after the delivery of the infant is advised. Carbetocin is recommended as an uterotonic, but the minimum effective dose has not been verified. We compared the efficacy of two doses of intravenous carbetocin (20 μg and 100 μg) in women undergoing elective caesarean delivery. Read More
World J Nucl Med 2018 Oct-Dec;17(4):219-222
Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Centre Annexe, Parel, Maharashtra, India.
The aim of this study was to explore the clinical efficacy of F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in tumor detection in patients with proven or suspected carcinoma of unknown primary origin (CUP) and making a subgroup-specific analysis. This was a retrospective, cross-sectional survey of patients with CUP syndrome who were referred for F-FDG PET-CT studies over a 2-year period. FDG-PET-CT scans were performed in compliance with the standard whole-body protocol, i. Read More
Sex Dev 2018 Dec 1. Epub 2018 Dec 1.
Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a disorder of sex development which affects 1 in 4,500 females and is characterized by agenesis of müllerian structures, including the uterus, cervix, and upper vagina. It can occur in isolation (type 1) or in conjunction with various anomalies (type 2), with a subset of these comprising müllerian, renal, and cervicothoracic abnormalities (MURCS) association. The genetic causes of MRKH have been investigated previously yielding limited results, with massive parallel sequencing becoming increasingly utilized. Read More
Toxicol Appl Pharmacol 2018 Nov 29;363:88-97. Epub 2018 Nov 29.
UCIBIO, REQUIMTE, Departamento de Ciências Biológicas, Laboratório de Bioquímica, Faculdade de Farmácia, University of Porto, Porto, Portugal.
The endometrium is a particular sensitive target tissue for estradiol that is able to promptly modify its structure. Tamoxifen (TAM), a selective estrogen receptor modulator, was shown to promote a spectrum of uterine abnormalities, though the morphological and stereological effects of this drug in uterus is not clear. In this way, we have used an established model of ovariectomy followed by estradiol benzoate (EB) or TAM treatment and analyzed their effects in uterine histopathology and proliferation. Read More
Horm Mol Biol Clin Investig 2018 Dec 5. Epub 2018 Dec 5.
Regional Children's Clinical Hospital, Kemerovo, Russia.
Background The objective was to estimate ovarian reserve in adolescent girls born prematurely. Materials and methods Two hundred adolescent girls aged 15-16 years who were born prematurely and full term were studied with laboratory, ultrasound and statistical methods. Results Statistically significant differences of the main parameters that characterize ovarian reserve in adolescent girls born prematurely compared to those born full term were specified. Read More
Menopause 2018 Dec 3. Epub 2018 Dec 3.
TherapeuticsMD, Boca Raton, FL.
Objective: The aim of this study was to determine the clinical meaningfulness of TX-001HR in reducing moderate to severe vasomotor symptoms (VMS) in menopausal women with a uterus.
Methods: In the REPLENISH study (NCT01942668), women with moderate to severe hot flushes (≥7/d or ≥50/wk) were enrolled in a VMS substudy and randomized to four doses of daily TX-001HR (17β-estradiol/progesterone) or placebo. Participants assessed improvement of their VMS by the Clinical Global Impression and the Menopause-Specific Quality of Life (MENQOL) questionnaire, which were used to define clinical responders, clinically important differences (CIDs) or minimal CID (MCID) in VMS frequency. Read More
Histochem Cell Biol 2018 Dec 5. Epub 2018 Dec 5.
Cell and Reproductive Biology Lab, Discipline of Anatomy and Histology, School of Medical Sciences, University of Sydney, Camperdown, Australia.
During early pregnancy, the uterine luminal epithelial cells (UECs) and endometrial stromal cells (ESCs) undergo morphological changes to enable blastocyst implantation. The present study investigates, for the first time, the cytoskeletal-associated proteins and α-actinin superfamily members, α-parvin and β-parvin, during early pregnancy in the rat uterus. These two PARVA proteins are involved in cell adhesion, morphological changes and regulation of other cytoskeletal proteins, through binding with proteins such as actin and integrin-linked kinase. Read More
Case Rep Pathol 2018 31;2018:1392975. Epub 2018 Oct 31.
Department of Pathology, Farwaniya Hospital, Kuwait.
Background: The transformation of nonosseous soft tissue into bone is known as osseous metaplasia (OM). This condition most commonly affects the musculoskeletal and central nervous systems and it is a well-known phenomenon in different soft tissue organs. Rarely, OM can affect the uterus, which can extend into the cervix. Read More
Case Rep Obstet Gynecol 2018 1;2018:7865832. Epub 2018 Nov 1.
Department of Pediatrics, Hoshi General Hospital, Koriyama-shi, Fukushima, Japan.
Clitoral hypertrophy is caused by disorders of sex development and it is observed from birth in most cases. We encountered a patient in whom normal morphology at birth may have acquired deformity and hypertrophy. The patient was a 10-year-old girl with a chief complaint of pudendal deformity. Read More
BMJ 2018 Dec 4;363:k5135. Epub 2018 Dec 4.
J Obstet Gynaecol Can 2018 Dec 1. Epub 2018 Dec 1.
Department of Obstetrics and Gynecology, Faculty of Medicine, McGill University, Montréal, QC. Electronic address:
Objective: This study sought to evaluate perceptions and insights regarding uterine transplantation among members of a women's health care national specialty organization in Canada.
Methods: The investigators obtained permission and used an electronic survey developed by Bortoletto et al. to conduct a cross-sectional study of members of the SOGC between April and May 2018. Read More
BMC Womens Health 2018 Dec 4;18(1):196. Epub 2018 Dec 4.
Zealand University Hospital, University of Copenhagen, Copenhagen, Denmark.
Background: Lifestyle, in particular obesity and smoking has significant impacts on fertility and an important focus for the treatment of reproductive failures is the optimisation of periconceptional lifestyle behaviours. The preimplantation intrauterine environment within the uterus is also key for embryo development and early programming. Although the benefits a healthy periconceptional lifestyle are well described, there remains a paucity of data demonstrating the efficacy of interventions designed to optimise preconceptional lifestyle behaviours and choices. Read More
Sensors (Basel) 2018 Dec 2;18(12). Epub 2018 Dec 2.
Department of Analytical Chemistry, National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana, Slovenia.
Progesterone is an important hormone responsible, among others, for maintaining pregnancy via inhibition of uterus muscles activity; thus, following its concentration levels in pregnant women is of immense importance in the endeavor to prevent premature birth. In this work, the nanostructured bismuth film electrode (nsBiFE) was studied for detection of progesterone in neutral medium. Due to the ability to accumulate progesterone at the nsBiFE, the adsorptive cathodic stripping voltammetry was beneficially exploited. Read More
Rev Prat 2015 Nov;65(9):1135-1136
Académie de médecine, Paris, France.
Theriogenology 2018 Nov 26;126:36-40. Epub 2018 Nov 26.
Department of Equine Sciences, Faculty of Veterinary Medicine, Utrecht University, the Netherlands.
Equine embryos tolerate an unusually large degree of negative uterine asynchrony (recipient mare up to 5 days behind the donor mare). By contrast, positive asynchrony of more than 2 days results in a high incidence of early embryonic loss (EEL). Day 8 embryos range in diameter from approximately 130-1300 μm, with embryos smaller than 300 μm reported to suffer an increased incidence of EEL. Read More
J Gynecol Obstet Hum Reprod 2018 Dec 1. Epub 2018 Dec 1.
Département de Gynécologie Obstétrique, CHU Limoges, av Dominique Larrey, 87000 Limoges, France; INSERM, UMR-1248, CHU Limoges, 87000 Limoges, France. Electronic address:
Acta Obstet Gynecol Scand 2018 Dec 4. Epub 2018 Dec 4.
Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
We read the study by Pont et al. with great interest. They performed a retrospective population-based record linkage study evaluating the transfusion risk associated with intended vaginal birth after cesarean (VBAC) compared to elective repeat cesarean section (ERCS). Read More
J Obstet Gynaecol Res 2018 Dec 3. Epub 2018 Dec 3.
Department of Obstetrics and Gynecology, Aso Iizuka Hospital, Iizuka, Fukuoka, Japan.
Uterine rupture is rare but may result in both maternal and fetal death. The factors involved in such deaths depend on each case, but uterine artery embolization (UAE), the common treatment for hemorrhage, is possibly one factor. UAE may be related to uterine rupture or placenta accreta, but few data exist regarding UAE and uterine rupture. Read More
Drug Dev Res 2018 Dec 3. Epub 2018 Dec 3.
Department of Gynaecology and Obstetrics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China.
Primary dysmenorrhea affects the quality of life in young women, particularly school and work performance. This study investigated the mechanisms of penehyclidine hydrochloride (PHC) efficacy on a rat model of primary dysmenorrhea. The model was induced by injecting both estradiol benzoate and oxytocin. Read More
Cureus 2018 Sep 25;10(9):e3361. Epub 2018 Sep 25.
Neurosurgery, Seattle Science Foundation, Seattle, USA.
Endometriosis is a gynecological disorder identified by the presence of ectopic endometrial tissue outside the uterus. Largely, it affects reproductive-aged women and is a major cause of infertility. Clinical manifestations of endometriosis include dyspareunia, cyclic menstrual pain, chronic pelvic pain, and dyschezia, all of which can affect the patient's quality of life and health severely; therefore, it is paramount that medical treatment is initiated as soon as endometriosis is suspected clinically. Read More
Cureus 2018 Sep 25;10(9):e3358. Epub 2018 Sep 25.
Internal Medicine, Brookdale University Hospital, New York, USA.
Atypical hemolytic uremic syndrome (aHUS) is a kidney disorder that is frequently unrecognized during its progression, and misdiagnosed with more common etiologies of microangiopathic hemolytic anemia (MAHA): hemolytic uremic syndrome, disseminated intravascular coagulation, and thrombotic thrombocytopenic purpura (TTP). During pregnancy, the diagnosis of aHUS is furthermore challenging. The clinical presentation of aHUS may mimic pre-eclampsia as it occurred to the patient described in the case report. Read More
Case Rep Obstet Gynecol 2018 30;2018:5067276. Epub 2018 Oct 30.
Department of Gynecology, Francisco Gentil Portuguese Oncology Institute, Porto, Portugal.
Benign Metastasizing Leiomyoma (BML) is a rare condition with few cases reported in the literature. It is usually incidentally diagnosed several years after a primary gynecological surgery for uterine leiomyoma. Differential diagnosis of BML is complex requiring an extensive work-up and exclusion of malignancy. Read More
Toxicol Res (Camb) 2018 Nov 24;7(6):1164-1172. Epub 2018 Jul 24.
Key Laboratory of Environment and Health , Ministry of Education & Ministry of Environmental Protection , and State Key Laboratory of Environmental Health (Incubation) , School of Public Health , Tongji Medical College , Huazhong University of Science and Technology , Wuhan , Hubei , People's Republic of China . Email:
Pregnant women are a unique group undergoing profound structural modifications in uterus, breast, adipose tissue and extracellular fluids. Amino acid metabolic stress is a unique physical process that occurs during pregnancy. Metals constitute a fundamental part of the maternal body and have a universal effect on amino acid metabolism. Read More
Facts Views Vis Obgyn 2018 Mar;10(1):47-50
Sint-Jozef Kliniek, Department of gynecology and obstetrics, Kasteelstraat 23, 2880 Bornem, Belgium.
Undescended ovary is a rare congenital gynecologic condition, frequently associated with urogenital malformations including unicornuate uterus and ectopic kidneys or renal agenesis. Although ectopic ovaries are mostly found during an infertility work up, its role in infertility is still unknown. We report a 38-year-old patient presenting with pain in the right lower quadrant. Read More
Facts Views Vis Obgyn 2018 Mar;10(1):5-18
Ovarian Cancer Laboratory, Veterans Affairs Medical Center, Kansas City, MO 64128, United States.
Obesity has an influence on the risk and prognosis of different types of cancers of the female reproductive tract. In the uterus, a common site for neoplasms is the endometrium, the inner lining tissue. Generally, obesity has been documented to be involved in endometrioid carcinoma of the endometrium. Read More
Iran J Med Sci 2018 Nov;43(6):623-632
Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Background: Several plants have been shown to possess antioxidant and estrogenic properties that can be useful in postmenopausal bone-loss prevention. The present study aimed to investigate the anti-osteoporotic effects of the hydroalcoholic extract of the (PG) fruit in ovariectomized (OVX) rats.
Methods: Sixty female Sprague-Dawley rats were randomly divided into 6 groups: a control positive group, a sham-operated group, an OVX group given normal saline (OVX-only group), and 3 treatment groups comprising 2 OVX groups treated orally with 500 and 1000 mg/kg/d of the hydroalcoholic extract of the PG fruit respectively and an OVX group treated with an injection of 0. Read More
Maturitas 2018 Nov 28. Epub 2018 Nov 28.
Department of Gynecological, Obstetrical and Urological Sciences, 'Sapienza' University of Rome, Rome, Italy.
Objective: To evaluate the tolerability and safety of ospemifene in treating dyspareunia associated with postmenopausal vulvo- vaginal atrophy (VVA).
Methods: The literature was searched through to 31 July 2018 to identify randomized controlled trials comparing ospemifene 60 mg against placebo for the treatment of VVA. Two groups of outcomes were selected: 1) side-effects, including hot flushes, urinary tract infection (UTI), headache, deep venous thrombosis (DVT), coronary heart disease (CHD), cardiovascular event (CVE), discontinuation due to side-effects, serious adverse event (SAE); 2) Safety, in relation to endometrial thickness, vaginal bleeding, breast tenderness, breast and endometrial cancer. Read More
Exp Biol Med (Maywood) 2018 Dec 3:1535370218817503. Epub 2018 Dec 3.
1 Unidade de Biotecnologia, Universidade de Ribeirão Preto - UNAERP, Ribeirão Preto, SP 14096-900, Brazil.
Impact Statement: The results of this work provide preliminary evidence that ovariectomized rats display the vaginal smear cells typical of the estrous phase of mature rats after long-term ingestion of Colocasia esculenta flavonoid glycosides. Moreover, the treatment caused beneficial effects on endocrine and reproductive organs compared to estradiol. The animals did not exhibit significant body weight alterations among the groups, demonstrating the maintenance of standard metabolism and energy balance. Read More
Pol J Pathol 2018 ;69(3):321-324
Endosalpingiosis is a benign condition characterized by the presence of tubal epithelium outside the fallopian tube and the absence of endometrial stroma. Florid cystic endosalpingiosis is a very rare form of endosalpingiosis that presents as a tumor-like lesion. We report the case of a 67-year-old woman who presented with a cystic lesion of the uterus. Read More
Medicine (Baltimore) 2018 Nov;97(48):e13305
Departments of Urology.
Rationale: Persistent Müllerian duct syndrome (PMDS) is rare form of male pseudohermaphroditism characterized by the presence of uterus and fallopian tubes with normal external genitalia and secondary sexual characteristics. Transverse testicular ectopia (TTE) is also a rare form of testicular ectopia that may be associated with PMDS.
Patient Concerns: We present a 2-year-old boy who presented with bilateral non-palpable testes with left inguinal mass. Read More
Hum Reprod 2018 Nov 30. Epub 2018 Nov 30.
Family Planning Research Institute, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
Study Question: What is the role of the programmed cell death-1 (PD-1)/PD-1 ligand-1 (PD-L1) axis in macrophage polarization during early pregnancy?
Summary Answer: PD-1 signaling is a major regulator of macrophage differentiation and function, and it is critical for the success of a pregnancy.
What Is Known Already: The predominance of decidual macrophages (DMs) with an M2 phenotype is an important contributor to maternal-fetal tolerance during early pregnancy.
Study Design, Size, Duration: Twenty-four women with recurrent miscarriage (RM) and 70 women undergoing elective termination of an early normal pregnancy (NP) were included. Read More
J Neurosurg 2018 Oct 1:1-4. Epub 2018 Oct 1.
Levonorgestrel-releasing intrauterine devices (LIUDs) are thought to release this progestin locally in the uterus to limit side effects. Authors here present a case of treatment-refractory hydrocephalus and pseudomeningocele (PMC), both of which fully resolved after LIUD removal.A 35-year-old woman with an implanted LIUD developed symptomatic PMC and hydrocephalus after suboccipital craniectomy for Chiari malformation type I. Read More
Lond Med Phys J 1833 May;14(83):365-370
Lond Med Phys J 1830 Nov;9(53):415-417
Lond Med Phys J 1827 Dec;3(18):495-497
Member of the Royal College of Surgeons in London.
Lond Med Phys J 1827 Sep;3(15):216-218