155,211 results match your criteria Uterine Cancer

Repeated intravenous indocyanine green application to prove uterine perfusion during uterus transposition.

Int J Gynecol Cancer 2022 Jun 28. Epub 2022 Jun 28.

Department of Special Operative and Oncologic Gynecology, Asklepios Kliniken Hamburg GmbH - Asklepios Altona, Hamburg, Germany

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Trends and predictors of hysterectomy prevalence among women in the United States.

Am J Obstet Gynecol 2022 Jun 25. Epub 2022 Jun 25.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.

Background: Hysterectomy is the most common non-obstetric medical procedure performed in U.S. women. Read More

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Health-Related Quality of Life of Patients with Cervical Cancer According to the Duration of Treatment and Cancer Progression.

Asian Pac J Cancer Prev 2022 Jun 1;23(6):1945-1950. Epub 2022 Jun 1.

National Evidence-based Healthcare Collaborating Agency, City, Seoul, South Korea.

Objective: The purpose of this study was to assess health-related quality of life (HRQoL) in Korean patients with cervical cancer according to the duration of treatment and cancer progression of cervical cancer.

Methods: This study included 452 outpatients with cervical intraepithelial neoplasia (CIN) or invasive cervical cancer from six tertiary hospitals in South Korea. The questionnaire included the EQ-5D-3L instrument, patients' age, cancer progression (CIN or invasive cervical cancer), treatment duration (<1 year, ≥1 year but <2 years, and ≥2 years), treatment method (surgery, chemotherapy, radiation therapy), and presence of recurrence. Read More

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β-Klotho inhibits CSF-1 secretion and delays the development of endometrial cancer.

Cell Cycle 2022 Jun 28:1-13. Epub 2022 Jun 28.

Department of Orthopedics, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu, China.

Senescent cells can drive tumors development by promoting chronic inflammation. There is a significant correlation between β-Klotho expression profiles and endometrial cancer (EC). However, how β-Klotho regulates the occurrence and development of uterine EC remains to be further studied. Read More

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Metagenomic analysis of the microbiome of the upper reproductive tract: combating ovarian cancer through predictive, preventive, and personalized medicine.

EPMA J 2022 Jun 23:1-12. Epub 2022 Jun 23.

Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Purpose: We investigated whether ovarian cancer could alter the genital microbiota in a specific way with clinical values. Furthermore, we proposed how such changes could be envisioned in a paradigm of predictive, preventive, and personalized medicine (PPPM).

Methods: The samples were collected using cotton swabs from the cervical, uterine cavity, fallopian tubes, and ovaries of patients subjected to the surgical procedures for the malignant/benign lesions. Read More

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Incidence of fistula occurrence in patients with cervical cancer treated with bevacizumab: data from real-world clinical practice.

Int J Clin Oncol 2022 Jun 27. Epub 2022 Jun 27.

Department of Obstetrics and Gynecology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

Background: This study aimed to determine the incidence of pelvic fistulas in cervical cancer patients treated with bevacizumab in Japanese clinical practice.

Methods: A post-marketing surveillance (PMS) study was conducted between June 2016 and February 2018 to survey physicians who treated advanced or recurrent cervical cancer patients with bevacizumab (according to the product label). The clinical/treatment status of patients with pelvic fistulas was assessed in an additional retrospective case series study. Read More

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The impact of COVID-19 on the screening of colorectal, gastric, breast and cervical cancer in Korea.

Epidemiol Health 2022 Jun 21:e2022053. Epub 2022 Jun 21.

Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.

Objectives: The COVID-19 pandemic has affected the utilization of healthcare services, such as participation in cancer screening programs. We compared cancer screening participation rates for colorectal, gastric, breast, and cervical cancers among participants in the National Cancer Screening Program (NCSP) in 2019 and 2020 to address the potential distraction effect of COVID-19 on cancer screening.

Methods: Data from the NCSP for four cancer types (stomach, colorectal, breast and cervical) in 2019 and 2020 were used to calculate cancer screening participation rates by calendar month, gender, age group, and geographical region. Read More

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[Comparison of the Pap smear with conventional technique versus modified technique].

Rev Med Inst Mex Seguro Soc 2022 Mar 1;60(2):164-170. Epub 2022 Mar 1.

Instituto Mexicano del Seguro Social, Coordinación Auxiliar Médica de Investigación, Servicio de Colposcopía. La Paz, Baja California Sur, México.

Background: Despite the fact that the Papanicolaou technique is the most effective method of prevention and detection of cervical cancer, the precision of this tool remains controversial; Because of this, there are medical and scientific efforts to improve the quality of the procedure.

Objective: Compare the quality of sampling between the conventional and modified technique.

Material And Methods: Descriptive and comparative observational study in 150 cervical cytology samples (75 conventional technique samples and 75 in modified technique) in women aged 25 to 64 years. Read More

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The Effects of Theory-Based Educational Intervention and WhatsApp Follow-up on Papanicolaou Smear Uptake Among Postnatal Women in Malaysia: Randomized Controlled Trial.

JMIR Mhealth Uhealth 2022 Jun 27;10(6):e32089. Epub 2022 Jun 27.

Department of Community Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia.

Background: Despite the availability and accessibility of free Papanicolaou (Pap) smear as a screening tool for cervical cancer, the uptake of Pap smear in Malaysia has not changed in the last 15 years. Previous studies have shown that the high uptake of Pap smear reduces the mortality rate of patients with cervical cancer. The low uptake of Pap smear is multifactorial, and the problem could be minimized through the use of mobile technologies. Read More

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Trastuzumab Deruxtecan-Induced Interstitial Lung Disease/Pneumonitis in ERBB2-Positive Advanced Solid Malignancies: A Systematic Review.

Drugs 2022 Jun 27. Epub 2022 Jun 27.

Department of Medicine, University of California Irvine School of Medicine, 101 The City Drive South, Building 200, Room 410, ZOT 4061, Orange, CA, 92868, USA.

Background And Objective: Trastuzumab deruxtecan (T-DXd) is a novel anti-ERBB2 antibody drug conjugate that appears to be associated with an increased risk of lung toxicity. We performed a systematic review to describe the incidence, severity, and management of T-DXd-induced interstitial lung disease (ILD) or pneumonitis.

Methods: We searched PubMed/MEDLINE, Embase, Cochrane, and Web of Sciences through to 1 January, 2022, for human clinical trials that assessed T-DXd in adults with ERBB2-positive advanced solid tumors and described the rate of ILD/pneumonitis. Read More

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High-grade cervical dysplasia in a woman with uterine didelphys: A case report.

Gynecol Oncol Rep 2022 Aug 17;42:101027. Epub 2022 Jun 17.

NN Alexandrov National Cancer Centre, Minsk, Belarus.

The combination of lower genital tract carcinomas with genitourinary malformations is a rare occurrence. The purpose of this report is to describe the case of high-grade cervical dysplasia of the left cervix of a woman with a uterine didelphys and additional urinary tract malformations. Read More

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Safety and feasibility of laterally extended endopelvic resection for sarcoma in the female genital tract: a prospective cohort study.

Obstet Gynecol Sci 2022 Jun 27. Epub 2022 Jun 27.

Department of Obstetrics and Gynecology, Dongguk University College of Medicine, Goyang, Korea.

Objective: This study aims to evaluate the safety and feasibility of laterally extended endopelvic resection (LEER) for sarcoma in the female genital tract.

Methods: We prospectively recruited gynecologic cancer patients with sarcoma arising from female genital tract who underwent LEER at Seoul National University Hospital from December 2016 to March 2021. Clinicopathologic characteristics, surgical outcomes including postoperative complications and pain control, and survival outcomes of the patients were investigated. Read More

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Sarcoma of unknown primary: myth or reality?

J Egypt Natl Canc Inst 2022 Jun 27;34(1):27. Epub 2022 Jun 27.

University of Ioannina, Ioannina, Greece.

Background: Sarcoma of unknown primary (SUP) designates an enigmatic entity with histologic confirmation of a metastatic tumor without an identifiable primary after a thorough diagnostic workup. The term "unknown primary" is heavily debatable given that sarcomas can arise from any tissue that harbors its histological structure. In this review, we discuss the validity of SUP as a distinct entity. Read More

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Endometrial Biopsy in Low-Risk Women: Are We Over-Investigating?

J Obstet Gynaecol Can 2022 Jun 23. Epub 2022 Jun 23.

Centre Hospitalier de l'Université de Montréal, Department of Obstetrics-Gynaecology of the Université de Montréal, Montreal, QC, 1000 rue Saint-Denis, Montréal, Québec, Canada, H2X 0C1.

The appropriate age at which to perform endometrial biopsy for abnormal uterine bleeding (AUB) is controversial. This study aimed to determine the prevalence of malignant and premalignant pathologies in women aged 41-49 years with AUB and without risk factors for endometrial cancer. Records of women who had undergone a biopsy at the gynaecology clinic of the Centre hospitalier de l'Université de Montréal between 2014 and 2018 were reviewed. Read More

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Enhanced synergistic antitumor effect of a DNA vaccine with anticancer cytokine, MDA-7/IL-24, and immune checkpoint blockade.

Virol J 2022 Jun 25;19(1):106. Epub 2022 Jun 25.

Department of Influenza and Other Respiratory Viruses, Pasteur Institute of Iran, P.O. Box: 1316943551, Tehran, Iran.

Background: MDA-7/IL-24 cytokine has shown potent antitumor properties in various types of cancer without exerting any significant toxicity on healthy cells. It has also been proved to encompass pro-immune Th1 cytokine-like behavior. Several E7 DNA vaccines have developed against human papillomavirus (HPV)-related cervical cancer. Read More

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Fumarate hydratase is a novel gene for familial non-medullary thyroid cancer.

J Clin Endocrinol Metab 2022 Jun 25. Epub 2022 Jun 25.

Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia.

Context: the majority of cases of epithelial cell-derived thyroid cancer are sporadic. Familial non-medullary thyroid cancer (FNMTC) occurs in about 5-9% of cases, either as a part of known syndromes such as Cowden syndrome or in the form of familial clustering of 2 or more affected family members. Hereditary Leiomyoma and renal cell cancer (HLRCC) syndrome is a rare familial cancer syndrome. Read More

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Randomized multicenter phase II trial of prophylactic irradiation of para-aortic lymph nodes in advanced cervical cancer according to tumor hypoxia: Korean Radiation Oncology Group (KROG 07-01) study.

Int J Cancer 2022 Jun 25. Epub 2022 Jun 25.

Research Institute and Hospital, National Cancer Center, Goyang, South Korea.

We conducted a prospective phase II study on whether extended-field irradiation (EFI) confers survival benefits depending on hypoxic markers in locally advanced uterine cervical cancer (LAUCC). RNA-seq was performed to identify immune and hypoxic gene signatures. A total of 288 patients were randomized to either EFI or pelvic radiotherapy (PRT). Read More

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Atypical presentation of a rare gestational trophoblastic neoplasm: A case report.

J Pak Med Assoc 2022 Jun;72(6):1260-1262

Department of Surgery, Aga Khan University, Karachi, Pakistan.

A 34-year-old woman had a history of 3 miscarriages and presented with symptoms of an unproductive cough and rising serum beta-human chorionic gonadotropin (b-hCG) levels. There were no gynaecological symptoms. A diagnosis of Choriocarcinoma with pulmonary metastasis was made. Read More

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A multi-disciplinary approach to the management of intra-venous and intra-cardiac leiomymatosis: A case report.

J Pak Med Assoc 2022 Jun;72(6):1214-1217

Department of Cardio-Thoracic Surgery, Rehman Medical Institute, Peshawar, Pakistan.

We herein report a rare presentation of leiomyoma in a 46-year-old female who presented with complaints of shortness of breath on exertion associated with palpitations for the past one year with a history of irregular menstrual bleeding. Ultrasonography of the abdomen and pelvis revealed an enlarged, distorted uterus with multiple intramural fibroids. A trans-thoracic echocardiography was then performed which showed a large right atrial mass. Read More

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Awareness, screening, practices and attitudes of cervical cancer among doctors and nursing staff working at a tertiary care centre.

J Pak Med Assoc 2022 Jun;72(6):1025-1030

Department of Gynaecology and Obstetrics, Jinnah Postgraduate Medical Centre, Karachi, Pakistan.

Objectives: To assess knowledge, attitude and practice of medical and paramedical staff about cervical cancer as well as its screening and prevention.

Methods: The descriptive cross-sectional study was conducted at the Jinnah Post-graduate Medical Centre, Karachi, from March 1 to August 30, 2019, and comprised women medical and paramedical staff randomly selected from different specialties. Data was collected using a structured questionnaire. Read More

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Salvage image-guided freehand interstitial brachytherapy for pelvic sidewall recurrence after hysterectomy for uterine malignancies.

Brachytherapy 2022 Jun 21. Epub 2022 Jun 21.

Department of Radiation Oncology, National Cancer Center Hospital, Tokyo, Japan.

Purpose: Pelvic sidewall recurrence after hysterectomy for uterine malignances has a poor prognosis, and the salvage therapy for this type of recurrence is still challenging. The purpose of this study was to investigate the efficacy of freehand high-dose-rate interstitial brachytherapy (HDR-ISBT) through the perineum using transrectal ultrasonography for this disease.

Methods And Materials: We retrospectively evaluated 42 patients with pelvic sidewall recurrence after hysterectomy for uterine cervical and endometrial cancers. Read More

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Allergy testing for Cremophor in a patient with cervical cancer with infusion reactions to paclitaxel and docetaxel.

BMJ Case Rep 2022 Jun 24;15(6). Epub 2022 Jun 24.

Obstetrics and Gynecology, Nippon Medical School Hospital, Bunkyo-ku, Tokyo, Japan.

A woman in her 30s with cervical cancer underwent postoperative chemotherapy and showed allergic reactions to multiple taxanes. As the patient had infusion reactions to both paclitaxel and docetaxel, a prick test with Cremophor was conducted. In the absence of an allergic reaction to etoposide, we determined that the patient was allergic to pure taxane compounds. Read More

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Retreatment with progestin for recurrence after complete response with fertility-sparing treatment in patients with endometrial cancer.

Int J Gynecol Cancer 2022 Jun 24. Epub 2022 Jun 24.

Hosan Women's Hospital, Seoul, Republic of Korea.

Objective: To assess the outcomes of retreatment using progestin for recurrence after a complete response with fertility-sparing treatment in patients with early endometrial cancer.

Methods: We retrospectively reviewed the data of patients with presumed stage IA, grade 1 endometrioid endometrial cancer who developed intra-uterine recurrence after a complete response with fertility-sparing treatment using progestin. Oncological and pregnancy outcomes were analyzed after repeated fertility-sparing treatment. Read More

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MicroRNA 182, 183, 200a, and 200b exhibit strong correlations but no involvement in PTEN protein regulation in uterine endometrial carcinoma.

Pathol Res Pract 2022 Jun 17;236:153986. Epub 2022 Jun 17.

Laboratory of Histopathology and Cytopathology, Department of Laboratory Sciences, Gunma University Graduate School of Health Sciences, Maebashi, Gunma 371-8514, Japan. Electronic address:

Objective: In this study, we focused on five microRNAs (miRNAs) that have been reported to regulate phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene expression, namely miR-182, miR-183, miR-200a, miR-200b, and miR-205, and examined their relationships with PTEN protein expression in endometrial cancer tissues.

Methods: By utilizing paraffin-embedded blocks of normal endometrium (NE) and endometrial carcinoma (EC) tissue (40 cases each), we measured the expression of miRNAs by real-time PCR. Conversely, we examined PTEN protein expression by immunohistochemistry and computer-assisted image analysis. Read More

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Cervical Cancer Knowledge, Risk Factors and Screening Practices among Women Residing in Urban Slums of Lagos, Southwest, Nigeria.

West Afr J Med 2022 Jun;39(6):595-602

Olabisi Onabanjo University Teaching Hospital, Sagamu, Ogun State, Nigeria.

Background: Cervical cancer is the second leading cause of female cancer deaths in Nigeria. Routine cervical cancer screening and early treatment can prevent up to 80% of cervical cancers. This study was carried out to assess the knowledge, risk factors and practice of cervical cancer screening among women residing in urban slums of Lagos, Nigeria. Read More

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Time to death from cervical cancer and predictors among cervical cancer patients in Felege Hiwot Comprehensive Specialized Hospital, North West Ethiopia: Facility-based retrospective follow-up study.

PLoS One 2022 24;17(6):e0269576. Epub 2022 Jun 24.

Department of Midwifery, Debre Markos University, Debre Markos, Ethiopia.

Introduction: A sexually transmitted virus called the Human Papillomavirus is responsible for more than 99% of cervical cancer cases and its precursors. In 2019, the median survival time of cervical cancer patients at 5 years was 37 months. The survival time and predictors of death from cervical cancer vary in different study settings. Read More

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CA-125 monitoring in gynecologic cancer patients with COVID-19: A case series.

Gynecol Oncol Rep 2022 Aug 17;42:101029. Epub 2022 Jun 17.

Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, United States.

CA-125 has long been utilized as a surveillance biomarker for gynecologic malignancies but can be elevated in other conditions, including infection. A study of tumor markers in non-cancer patients saw a rise in CA-125 values during severe COVID-19 infections. Given the potential confounding effect this could have on surveillance and treatment planning, we sought to describe the impact of COVID-19 on CA-125 trends in a gynecologic oncology patient population. Read More

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Evaluation of the Concentration of Selected Elements in Patients with Cancer of the Reproductive Organs with Respect to Treatment Stage-Preliminary Study.

Nutrients 2022 Jun 7;14(12). Epub 2022 Jun 7.

Department of Clinical Nursing, Pomeranian Medical University in Szczecin, 71-210 Szczecin, Poland.

(1) Background: The aim of this study was to assess the concentrations of selected elements in female patients with cancer of the reproductive organs, taking into account the stage of treatment. (2) Methods: The study sample consisted of 51 patients with advanced endometrial cancer and ovarian cancer, undergoing chemotherapy. The median age of the studied patients with endometrial cancer was 66. Read More

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HPV and HIV Coinfection in Women from a Southeast Region of Romania-PICOPIV Study.

Medicina (Kaunas) 2022 Jun 3;58(6). Epub 2022 Jun 3.

Center for Research and Development of the Morphological and Genetic Studies of Malignant Pathology, Ovidius University of Constanta, 145 Tomis Blvd., 900591 Constanta, Romania.

: Romania faces one of the highest cervical cancer burdens in Europe though it is a preventable cancer through population screening by cytology and human papillomavirus (HPV) detection. Also, it has one of the highest incidences of human immunodeficiency virus (HIV) infection. HPV and HIV coinfection are frequently encountered. Read More

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Cervical Cancer Prevention in the Era of the COVID-19 Pandemic.

Medicina (Kaunas) 2022 May 29;58(6). Epub 2022 May 29.

Department of Oncologic Gynecology and Obstetrics, The Center of Postgraduate Medical Education, 00-416 Warsaw, Poland.

: Cervical cancer (CC) is the fourth most common cause of cancer-related morbidity and mortality among women worldwide. CC prevention is based on screening and HPV vaccination. The COVID-19 pandemic has caused difficulties in implementing CC-preventative measures. Read More

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