135,979 results match your criteria Uterine Cancer


Do vaginal recurrence rates differ among adjuvant vaginal brachytherapy regimens in early-stage endometrial cancer?

Brachytherapy 2019 Apr 17. Epub 2019 Apr 17.

Department of Radiation Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT. Electronic address:

Purpose: We sought to retrospectively examine clinical outcomes for three adjuvant vaginal high-dose-rate (HDR) brachytherapy regimens after hysterectomy for early-stage endometrial cancer.

Methods: Included were women of all ages from two independent hospital systems diagnosed with Stage I-II endometrial cancer of any grade between 2000 and 2016 who underwent hysterectomy followed by adjuvant vaginal cylinder HDR brachytherapy with either 7.0 Gy × 3 fractions prescribed to 0. Read More

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http://dx.doi.org/10.1016/j.brachy.2019.03.001DOI Listing

Magnetic resonance imaging response in patients treated with definitive radiation therapy for medically inoperable endometrial cancer-Does it predict treatment response?

Brachytherapy 2019 Apr 17. Epub 2019 Apr 17.

Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA. Electronic address:

Purpose: Many patients with endometrial cancer cannot undergo surgery and instead receive definitive radiation therapy (RT). We investigate the correlation between MRI response to RT and clinical outcomes.

Methods And Materials: Women with inoperable, clinical Stage I endometrial cancer were treated with definitive brachytherapy (BT) with/without pelvic RT (PRT). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15384721183064
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http://dx.doi.org/10.1016/j.brachy.2019.03.005DOI Listing
April 2019
1 Read

Over Expressed TKTL1, CIP-2A, and B-MYB Proteins in Uterine Cervix Epithelium Scrapings as Potential Risk Predictive Biomarkers in HR-HPV-Infected LSIL/ASCUS Patients.

Front Oncol 2019 3;9:213. Epub 2019 Apr 3.

Human Histology and Embryology Unit, University of Verona Medical School, Verona, Italy.

High oncogenic risk human papillomaviruses (HR-HPVs) promote cervical carcinoma development, the fourth most common feminine cancer. A slow oncodevelopmental phase-defined histopathologically as Cervical Intraepithelial Neoplasia (CIN) grades 1-3, or cytologically as Low- or High-grade Squamous Intraepithelial Lesions (LSIL or HSIL)-precedes the malignancy. Cervical carcinoma screenings through HR-HPV genotyping and Pap smears are regularly performed in Western countries. Read More

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http://dx.doi.org/10.3389/fonc.2019.00213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456695PMC

Radiation induces changes in toll-like receptors of the uterine cervix of the rat.

PLoS One 2019 18;14(4):e0215250. Epub 2019 Apr 18.

Department of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

Radiotherapy is an important therapeutic approach against cervical cancer but associated with adverse effects including vaginal fibrosis and dyspareunia. We here assessed the immunological and oxidative responses to cervical irradiation in an animal model for radiation-induced cervicitis. Rats were sedated and either exposed to 20 Gy of ionising radiation given by a linear accelerator or only sedated (controls) and euthanized 1-14 days later. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215250PLOS
April 2019
3 Reads

Syphilitic Cervicitis with Cervical Cancer Presenting as Oropharyngeal Syphilis: A Case Report.

Intern Med 2019 Apr 17. Epub 2019 Apr 17.

Department of General Internal Medicine, Akashi Medical Center, Japan.

We herein report a patient with syphilitic cervicitis and cervical cancer presenting as oropharyngeal syphilis. A 31-year-old Japanese woman with a history of unprotected vaginal and oral sex visited our hospital with right submandibular adenomas and erythema in the extremities. The fornix uteri was red, with a nodule noted. Read More

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https://www.jstage.jst.go.jp/article/internalmedicine/advpub
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http://dx.doi.org/10.2169/internalmedicine.2426-18DOI Listing
April 2019
2 Reads

Endometriosis.

Endocr Rev 2019 Apr 17. Epub 2019 Apr 17.

Departments of Obstetrics and Gynecology, Northwestern University, Chicago, IL.

Pelvic endometriosis is a complex syndrome characterized by an estrogen-dependent chronic inflammatory process that affects primarily pelvic tissues, including the ovaries. It is caused when shed endometrial tissue travels retrograde into the lower abdominal cavity. Endometriosis is the most common cause of chronic pelvic pain in women and is associated with infertility. Read More

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http://dx.doi.org/10.1210/er.2018-00242DOI Listing
April 2019
1 Read
21.059 Impact Factor

CXCR7 signaling promotes breast cancer survival in response to mesenchymal stromal stem cell-derived factors.

Cell Death Discov 2019 11;5:87. Epub 2019 Apr 11.

3Cancer Research Center, Qatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Qatar Foundation (QF), PO Box 34110, Doha, Qatar.

The interaction between cancer cells and molecular cues provided by tumor stromal cells plays a crucial role in cancer growth and progression. We have recently reported that the outcome of interaction between tumor cells and stromal cells is dependent on the gene expression signature of tumor cells. In the current study, we observed that several cancer cell lines, e. Read More

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http://dx.doi.org/10.1038/s41420-019-0169-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459874PMC
April 2019
1 Read

A Comparative Study for Selectivity of Micronuclei in Cervical Exfoliated Cells on Chronic Boron Effects.

J Cytol 2019 Apr-Jun;36(2):75-78

Department of Medical Biology, School of Medicine, Faculty of Health Sciences, Manisa Celal Bayar University, Manisa, Turkey.

Background: Cervical cancer is one of the most frequent malignancies in women. Micronucleus (MN) testing has gained popularity as a biomarker in early diagnosis of many types of cancer.

Aims: This study aims to investigate the role of MN testing on early detection of cervical cancer and the effect of boron exposure on cervical cells. Read More

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http://dx.doi.org/10.4103/JOC.JOC_185_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425774PMC
April 2019
1 Read

Benign metastasizing leiomyoma presenting with miliary pattern and fatal outcome: Case report with molecular analysis & review of the literature.

Respir Med Case Rep 2019 28;27:100831. Epub 2019 Mar 28.

Department of Pathology and Cell Biology, Columbia University Medical Center, New York, USA.

Benign metastasizing leiomyoma (BML) is a rare benign smooth muscle neoplasm that originates in the uterus and metastasizes to distant sites-most commonly the lungs. BMLs are often found incidentally in patients with a history of uterine leiomyoma(s) and tend to be indolent. Occasionally they may be symptomatic and rarely follow an aggressive clinical course. Read More

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http://dx.doi.org/10.1016/j.rmcr.2019.100831DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446132PMC
March 2019
1 Read

Myometrial Transcriptional Signatures of Human Parturition.

Front Genet 2019 1;10:185. Epub 2019 Apr 1.

Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, OH, United States.

The process of parturition involves the transformation of the quiescent myometrium (uterine smooth muscle) to the highly contractile laboring state. This is thought to be driven by changes in gene expression in myometrial cells. Despite the existence of multiple myometrial gene expression studies, the transcriptional programs that initiate labor are not known. Read More

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https://www.frontiersin.org/article/10.3389/fgene.2019.00185
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http://dx.doi.org/10.3389/fgene.2019.00185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452569PMC
April 2019
2 Reads

Constitutively active ESR1 mutations in gynecologic malignancies and clinical response to estrogen-receptor directed therapies.

Gynecol Oncol 2019 Apr 13. Epub 2019 Apr 13.

Duke University Medical Center, Durham, NC, United States of America.

Objective: Endocrine therapy is often considered as a treatment for hormone-responsive gynecologic malignancies. In breast cancer, activating mutations in the estrogen receptor (mutESR1) contribute to therapeutic resistance to endocrine therapy, especially aromatase inhibitors (AIs). The purpose of this study was to evaluate the frequency and clinical relevance of ESR1 genomic alterations in gynecologic malignancies. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.04.010DOI Listing
April 2019
1 Read

Uterine Epithelial Development and EZH2: It's Important for More than Just Cancer.

Am J Pathol 2019 Apr 12. Epub 2019 Apr 12.

Department of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address:

This commentary highlights the article by Fang et al that describes the role of EZH2 in endometrial development. Read More

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http://dx.doi.org/10.1016/j.ajpath.2019.03.007DOI Listing
April 2019
1 Read

Aberrant Hypermetabolism of Benign Uterine Leiomyoma on 18F-FDG PET/CT.

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

Department of Gynecologic Oncology-Hospital Sírio-Libanês, São Paulo, Brazil.

Leiomyomas are prevalent benign smooth muscle tumors in the uterus, displaying variable degrees of FDG uptake on PET/CT. The glucose metabolism intensity of those lesions relies on biologic features and markedly increased FDG accumulation is more typically related to malignant diseases, as in the case of leiomyosarcomas. Notwithstanding that uterine fibroids typically exhibit mild to moderate FDG uptake, in this article we report a case of unexpectedly intense hypermetabolism of a benign uterine leiomyoma on a PET/CT scan performed for initial staging of a breast cancer patient. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002580DOI Listing
April 2019
3 Reads

The Impact of Addition of Consolidation Chemotherapy to Standard Cisplatin-Based Chemoradiotherapy in Uterine Cervical Cancer: Matter of Distant Relapse.

J Oncol 2019 11;2019:1217838. Epub 2019 Mar 11.

Medical Oncology Department, A.C.Camargo Cancer Center, Sao Paulo, 211 Professor Antonio Prudente Street, 01509-900 Liberdade, Brazil.

Background: Treatment of advanced uterine cervical cancer has advanced little in the last 15 years. Although two phase III trials showed survival benefit with the addition of consolidation chemotherapy (CT) after cisplatin-based chemoradiotherapy (RTCT), it is not considered standard of care. We aimed to evaluate the benefit of consolidation CT compared to no additional treatment in patients treated with RTCT. Read More

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http://dx.doi.org/10.1155/2019/1217838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432701PMC
March 2019
1 Read

Prognostic value of ADC quantification for clinical outcome in uterine cervical cancer treated with concurrent chemoradiotherapy.

Eur Radiol 2019 Apr 12. Epub 2019 Apr 12.

Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Objectives: To investigate the prognostic value of diffusion-weighted imaging (DWI) in predicting clinical outcome in patients with cervical cancer after concurrent chemoradiotherapy (CCRT).

Methods: We enrolled 124 cervical cancer patients who received definitive CCRT and underwent 3 T-MRI before and 1 month after initiating treatment. The mean apparent diffusion coefficient (ADC) value was measured on the tumor and the changes in ADC percentage (ΔADC) between the two time points were calculated. Read More

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http://dx.doi.org/10.1007/s00330-019-06204-wDOI Listing
April 2019
1 Read
4.014 Impact Factor

The Case for an Estrogen-iron Axis in Health and Disease.

Exp Clin Endocrinol Diabetes 2019 Apr 12. Epub 2019 Apr 12.

Sharjah Institute for Medical Research, University of Sharjah, United Arab Emirates.

Clinical and experimental evidence suggest that estrogen manipulates intracellular iron metabolism and that elevated levels of estrogen associate with increased systemic iron availability. This has been attributed to the ability of estrogen to suppress hepcidin synthesis, maintain ferroportin integrity and enhance iron release from iron-absorbing duodenal enterocytes and iron-storing macrophages and hepatocytes. These observations speak of a potential "estrogen-iron" axis that manipulates iron metabolism in response to hematologic (erythropoiesis) and non-hematologic (uterine growth, pregnancy, lactation) needs for iron. Read More

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http://dx.doi.org/10.1055/a-0885-1677DOI Listing
April 2019
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LC/MS-Based Polar Metabolite Profiling Identified Unique Biomarker Signatures for Cervical Cancer and Cervical Intraepithelial Neoplasia Using Global and Targeted Metabolomics.

Cancers (Basel) 2019 Apr 10;11(4). Epub 2019 Apr 10.

Division of Cancer Epidemiology and Prevention, National Cancer Center, Madu-dong, Ilsandong-gu, Goyang-si, Gyeonggi-do 10408, Korea.

Cervical cancer remains one of the most prevalent cancers among females worldwide. Therefore, it is important to discover new biomarkers for early diagnosis of cervical intraepithelial neoplasia (CIN) and cervical cancer, preferably non-invasive ones. In the present study, we aimed to identify unique metabolic signatures for CINs and cervical cancers using global and targeted metabolomic profiling. Read More

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https://www.mdpi.com/2072-6694/11/4/511
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http://dx.doi.org/10.3390/cancers11040511DOI Listing
April 2019
4 Reads

Uterine Papillary Serous Carcinoma Arising in a Polyp: A Multicenter Retrospective Analysis on 75 Patients.

Am J Clin Oncol 2019 Apr 9. Epub 2019 Apr 9.

Unit of Obstetrics and Gynecology, Azienda USL-IRCCS of Reggio Emilia.

Objectives: The objectives of this study were to evaluate whether the international recommendations on the management of uterine papillary serous carcinoma arising in a polyp are uniformly followed in Italian Oncologic Centers and whether the strategy adopted is effective.

Materials And Methods: Patients with uterine papillary serous carcinoma arising in a polyp and who had undergone a hysterectomy were identified in the 2003-2013 database of 7 Italian Gynecologic Oncology Centers. Clinical and pathologic characteristics and outcomes were compared between staging procedure types. Read More

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http://dx.doi.org/10.1097/COC.0000000000000541DOI Listing
April 2019
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Outcomes of non-high grade serous carcinoma after neoadjuvant chemotherapy for advanced-stage ovarian cancer: a Korean gynecologic oncology group study (OV 1708).

BMC Cancer 2019 Apr 11;19(1):341. Epub 2019 Apr 11.

Department of Obstetrics and Gynecology, Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine, Seoul, South Korea.

Background: Outcomes of patients with ovarian high-grade serous carcinoma (HGSC) treated with neoadjuvant chemotherapy (NAC) have been widely studied, but there is limited information on the outcomes of patients with non-HGSC. This study aimed to evaluate the outcomes of NAC in non-HGSC patients with advanced-stage ovarian cancer.

Methods: We conducted a retrospective cohort study of patients who underwent NAC for advanced stage non-HGSC between 2002 and 2017 in 17 institutions. Read More

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http://dx.doi.org/10.1186/s12885-019-5514-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458623PMC
April 2019
1 Read

Second Uterine Curettage and the Number of Chemotherapy Courses in Postmolar Gestational Trophoblastic Neoplasia: A Randomized Controlled Trial.

Obstet Gynecol 2019 Apr 5. Epub 2019 Apr 5.

Departments of Obstetrics and Gynaecology, Community Medicine, Pathology, and Oncology, Mansoura University, Mansoura, Egypt; and the Departments of Surgery and Gynecologic Oncology, Erasmus MC Cancer Center, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Objective: To investigate the effect of second uterine curettage on the number of chemotherapy courses and relapse rate in low-risk postmolar gestational trophoblastic neoplasia.

Methods: In a phase III trial, patients with low risk gestational trophoblastic neoplasia were randomised (1:1) to a second curettage or no curettage group before methotrexate treatment. Eligibility criteria were serum human chorionic gonadotropin (hCG) level 5,000 international units/L or less and fit for treatment with methotrexate. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003232DOI Listing
April 2019
3 Reads

Tamoxifen use as a malignancy risk factor in postmenopausal women with endometrial polyps.

Menopause 2019 Apr 8. Epub 2019 Apr 8.

Department of Gynecology and Obstetrics, School of Medical Sciences, University of Campinas (Unicamp), Campinas (SP), Brazil.

Objective: We analyzed tamoxifen use as a malignancy risk factor in women with endometrial polyps.

Methods: This retrospective study included 675 women who underwent hysteroscopic polypectomy in 2010 to 2015 at the University of Campinas. Women were divided into tamoxifen use (n = 169) and no tamoxifen use (n = 506) groups. Read More

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http://dx.doi.org/10.1097/GME.0000000000001340DOI Listing
April 2019
1 Read

[A suspected carcinoma finding in the uterus].

Pathologe 2019 Apr 9. Epub 2019 Apr 9.

Institut für Pathologie am Clemenshospital, Düesbergweg 128, 48153, Münster, Deutschland.

Epithelioid tumor cells of a uterine perivascular epithelioid cell tumor (PEComa) may mimic carcinoma cells in an endometrial sampling (pitfall). Immunohistochemistry (HMB45 positive, keratin negative) helps in the differential diagnosis. Read More

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http://dx.doi.org/10.1007/s00292-019-0587-2DOI Listing
April 2019
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Breast and cervical cancer patients' experience in Addis Ababa city, Ethiopia: a follow-up study protocol.

BMJ Open 2019 Apr 9;9(4):e027034. Epub 2019 Apr 9.

Surveillance and Health Services Research, American Cancer Society, Atlanta, Georgia, USA.

Introduction: Cancer is an emerging public health problem in Ethiopia, with breast and cervical cancers accounting for over half of all newly diagnosed cancers in women. The majority of women with breast and cervical cancer are diagnosed at late stage of the disease and most patients do not receive care consistent with global standards. However, little is known about the health-seeking behaviours, barriers to early detection and treatment, patient-reported outcomes, financial burden and survival of women with breast and cervical cancer in the country. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-027034DOI Listing
April 2019
1 Read

Treat-and-Release Emergency Department Utilization by Patients With Gynecologic Cancers.

J Oncol Pract 2019 Apr 9:JOP1800639. Epub 2019 Apr 9.

1 University of Pennsylvania Health System, Philadelphia, PA.

Purpose: Seventeen percent of patients with cancer visit the emergency department (ED) annually, often with nonemergent complaints. We sought to describe the burden of treat-and-release ED utilization by patients with gynecologic cancers and to identify opportunities for improved triage.

Materials And Methods: Patients with gynecologic cancer diagnoses who were treated and released were identified within the Nationwide Emergency Department Sample, a stratified sample of US hospital-based ED visits, from 2009 to 2013. Read More

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http://dx.doi.org/10.1200/JOP.18.00639DOI Listing
April 2019
1 Read

Predictive Histologic Factors in Carcinosarcomas of the Uterus: A Multi-institutional Study.

Int J Gynecol Pathol 2019 May;38(3):205-215

Department of Pathology, Wayne State University (E.A., B.A., S.B., R.A.-F.) Department of Pathology, St John's Providence Hospital (M.K.), Detroit, Michigan Department of Pathology, Massachusetts General Hospital, Harvard University, Boston, Massachusetts (L.L., K.V.D.V., E.O.).

Uterine carcinosarcomas are rare aggressive biphasic neoplasms. Because of its rarity, limited data are available on potential prognostic parameters. While several studies support that carcinomatous components predict outcomes, others do not. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000497DOI Listing
May 2019
1 Read

FightHPV: Design and Evaluation of a Mobile Game to Raise Awareness About Human Papillomavirus and Nudge People to Take Action Against Cervical Cancer.

JMIR Serious Games 2019 Apr 8;7(2):e8540. Epub 2019 Apr 8.

HPV Research Group, Department of Research, Cancer Registry of Norway, Oslo, Norway.

Background: Human papillomavirus (HPV) is the most common sexually transmitted infection globally. High-risk HPV types can cause cervical cancer, other anogenital cancer, and oropharyngeal cancer; low-risk HPV types can cause genital warts. Cervical cancer is highly preventable through HPV vaccination and screening; however, a lack of awareness and knowledge of HPV and these preventive strategies represents an important barrier to reducing the burden of the disease. Read More

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http://dx.doi.org/10.2196/games.8540DOI Listing
April 2019
2 Reads

Zone Formation of Lymphocyte Infiltration at the Invasive Front Results in the Prolonged Survival of Individuals With Endometrial Serous Carcinoma and Endometrioid Carcinoma With Serous Component.

Anticancer Res 2019 Apr;39(4):2085-2089

Department of Obstetrics and Gynecology, National Defense Medical College Hospital, Tokorozawa, Japan.

Background/aim: This study aimed to evaluate the clinical significance of lymphocyte infiltration (LI) for patients with endometrial serous carcinoma and those with endometrioid carcinoma including serous component.

Patients And Methods: Patients who underwent surgery at our hospital between 1990 and 2013 were identified. LI was classified into strong LI, defined as a continuous thick zone of LI, and weak LI, defined as the lack of zone or scattered small foci of LI at the invasive front. Read More

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http://dx.doi.org/10.21873/anticanres.13320DOI Listing
April 2019
2 Reads

Development of a Vaginal Immobilization Device: A Treatment-planning Study of Carbon-ion Radiotherapy and Intensity-modulated Radiation Therapy for Uterine Cervical Cancer.

Anticancer Res 2019 Apr;39(4):1915-1921

Gunma University Heavy Ion Medical Center, Maebashi, Japan.

Aim: We developed a vaginal immobilization device for external radiotherapy in gynaecological malignancies and evaluated its bowel dose-reduction effect during carbon-ion radiotherapy (CIRT) and intensity-modulated radiation therapy (IMRT) in patients with cervical cancer.

Patients And Methods: Computed tomographic images obtained with and without the device in seven patients with cervical cancer were assessed. Treatment plans for CIRT and IMRT were generated, and dose-volume parameters (V, V, V, and D) of the rectum, sigmoidal colon, and bladder were evaluated. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13300DOI Listing
April 2019
2 Reads

Preventive Effects by Black Raspberries of Endometrial Carcinoma Initiation and Promotion Induced by a High-Fat Diet.

Mol Nutr Food Res 2019 Apr 5:e1900013. Epub 2019 Apr 5.

Department of Medicine, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.

Scope: The chemopreventive effects of black raspberries (BRBs) have not been studied in endometrial tumorigenesis. Here, they are examined in a mouse model of endometrial cancer.

Methods And Results: Wild-type and Pten heterozygous (+/-) female mice are weaned at 3 weeks and fed with four AIN-93G diets: 93G; 93G+5% BRBs powder; high-fat (HF); and HF+5% BRBs. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/mnfr.2019000
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http://dx.doi.org/10.1002/mnfr.201900013DOI Listing
April 2019
1 Read

IGF2 is Deregulated During the Development of Uterine Cervical Carcinoma in Indian Patients.

Biochem Genet 2019 Apr 4. Epub 2019 Apr 4.

Department of Oncogene Regulation, Chittaranjan National Cancer Institute, 37, S. P. Mukherjee Road, Kolkata, 700 026, India.

Uterine cervical carcinoma (CACX) is one of the leading causes of deaths in Indian women. Chromosomal alterations including 11p15.5 locus were reported in CACX. Read More

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http://dx.doi.org/10.1007/s10528-019-09917-1DOI Listing
April 2019
3 Reads

Ultrasonographic assessment of an induration caused by extravasation of a nonvesicant anticancer drug: A case report.

Medicine (Baltimore) 2019 Apr;98(14):e15043

Global Nursing Research Center.

Rationale: Induration may occur after an anticancer drug extravasation in patients who recurrently receive chemotherapy because of reduced choice of an appropriate vein for inserting a peripheral intravenous catheter, resulting in catheter placement difficulty. Although induration affects treatment, its size, shape, or hardness remains unclear in the conventional observation method using palpation and inspection. Here, we report our observation results in using ultrasonography to assess the induration that occurred after an anticancer drug extravasation as a new assessment method. Read More

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http://dx.doi.org/10.1097/MD.0000000000015043DOI Listing
April 2019
1 Read

Prevalence of cervical disease at age 20 after immunisation with bivalent HPV vaccine at age 12-13 in Scotland: retrospective population study.

BMJ 2019 Apr 3;365:l1161. Epub 2019 Apr 3.

Institute of Applied Health Services, University of Aberdeen, Aberdeen, UK.

Objective: To quantify the effect on cervical disease at age 20 years of immunisation with bivalent human papillomavirus (HPV) vaccine at age 12-13 years.

Design: Retrospective population study, 1988-96.

Setting: National vaccination and cervical screening programmes in Scotland. Read More

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http://dx.doi.org/10.1136/bmj.l1161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446188PMC
April 2019
2 Reads

Cervical screening and risk of adenosquamous and rare histological types of invasive cervical carcinoma: population based nested case-control study.

BMJ 2019 Apr 3;365:l1207. Epub 2019 Apr 3.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden.

Objectives: To examine the association of cervical cytology screening with the risk of adenosquamous cell carcinoma (ASC) and rare histological types of invasive cervical carcinoma (RICC), using comprehensive registry data, and to assess tumour human papillomavirus status of ASC and RICC.

Design: Nationwide, population based, nested case-control study.

Setting: Sweden. Read More

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http://dx.doi.org/10.1136/bmj.l1207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446178PMC
April 2019
3 Reads

Combination of SB431542, CHIR99021 and PD0325901 has a synergic effect on abrogating valproic acid‑induced epithelial‑mesenchymal transition and stemness in HeLa, 5637 and SCC‑15 cells.

Oncol Rep 2019 Apr 1. Epub 2019 Apr 1.

Ultrasound Department, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China.

Epithelial‑mesenchymal transition (EMT) plays an important role in cancer progression, metastasis and drug resistance, and recent studies have revealed that neoplastic epithelial cells regain the stem cell state through EMT. Single‑agent targeted cancer therapy frequently fails due to acquired drug resistance. Therefore, multi‑agent targeted therapy exhibits advantages in fighting cancer cells. Read More

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http://dx.doi.org/10.3892/or.2019.7088DOI Listing
April 2019
5 Reads

Exosomal let-7d-3p and miR-30d-5p as diagnostic biomarkers for non-invasive screening of cervical cancer and its precursors.

Mol Cancer 2019 04 2;18(1):76. Epub 2019 Apr 2.

Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province, Women's Reproductive Health Key Laboratory of Zhejiang Province, Department of Gynecologic Oncology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Cervical cancer screening through detection and treatment of high-grade cervical intraepithelial neoplasia (CIN) is most successful in cancer prevention. However, the accuracy of the current cervical cancer screening tests is still low. The aim of this study was to develop a more accurate method based on circulating exosomal miRNAs. Read More

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http://dx.doi.org/10.1186/s12943-019-0999-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446401PMC
April 2019
3 Reads
4.257 Impact Factor

A forgotten disease: Pelvic congestion syndrome as a cause of chronic lower abdominal pain.

PLoS One 2019 2;14(4):e0213834. Epub 2019 Apr 2.

Department of Gynecology and Gynecological Oncology, University Women`s Hospital of Basel, University of Basel, Basel, Switzerland.

Objectives: Pelvic congestion syndrome is defined as chronic pelvic pain due to incompetent (dilated and refluxing) pelvic veins. The aim of this study was to investigate the prevalence of this condition by examining the prevalence of dilated ovarian and para-uterine veins in pre- and postmenopausal female patients, irrespective of their symptoms. We subsequently investigated how many women with dilated veins suffered from chronic pelvic pain. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213834PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445463PMC
April 2019
3 Reads

Relugolix: First Global Approval.

Authors:
Anthony Markham

Drugs 2019 Apr 1. Epub 2019 Apr 1.

Springer, Private Bag 65901, Mairangi Bay, 0754, Auckland, New Zealand.

The orally active nonpeptide gonadotropin-releasing hormone (GnRH)-receptor antagonist relugolix (Relumina) is being developed by Takeda and ASKA Pharmaceutical as a treatment for various sex hormone related disorders. Relugolix was recently approved for marketing in Japan as a treatment for symptoms associated with uterine fibroids, and studies evaluating the efficacy of the drug as treatment for endometriosis-associated pain and prostate cancer are currently underway. This article summarizes the milestones in the development of relugolix leading to this first approval for the treatment of symptoms associated with uterine fibroids. Read More

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http://dx.doi.org/10.1007/s40265-019-01105-0DOI Listing
April 2019
3 Reads

Carcinosarcoma of the uterine cervix: a rare pathological finding originating from mesonephric remnants.

BMJ Case Rep 2019 Mar 31;12(3). Epub 2019 Mar 31.

Gynecology Oncology, Instituto Português de Oncologia do Porto Francisco Gentil, Porto, Portugal.

Carcinosarcoma of the uterine cervix is a very rare tumour that has been described in less than 70 cases in the literature. It is less common compared with carcinosarcoma of the uterine corpus and it can have two origins: the Müllerian ducts and the mesonephric duct remnants. The association of mesonephric carcinoma with a sarcomatous component was reported in only 11 cases, including the following. Read More

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http://dx.doi.org/10.1136/bcr-2018-227050DOI Listing
March 2019
3 Reads

A 3-step intervention to improve adherence to cervical cancer screening: The SCAN randomized controlled trial.

Prev Med 2019 Mar 30;123:250-261. Epub 2019 Mar 30.

EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal; Departamento de Ciências da Saúde Pública e Forenses e Educação Médica, Faculdade de Medicina da Universidade do Porto, Porto, Portugal. Electronic address:

The aim of this study was to test the effectiveness of a stepwise intervention with an increasing level of complexity and cost to increase adherence to organized cervical cancer screening. This was a randomized (1: 1) controlled trial, conducted among 13 Portuguese primary health care units. Participants (n = 1220) were women aged 25-49 years, eligible for cervical cancer screening, with a mobile phone number available. Read More

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http://dx.doi.org/10.1016/j.ypmed.2019.03.025DOI Listing
March 2019
4 Reads

Effect of cimicifuga racemosa on menopausal syndrome caused by LHRH-a in breast cancer.

J Ethnopharmacol 2019 Mar 29;238:111840. Epub 2019 Mar 29.

Department of Breast Tumor Surgery, Zhejiang Cancer Hospital, Hangzhou, PR China. Electronic address:

Ethnopharmacological Relevance: Cimicifuga racemose is previously proved effective on nature menopausal syndrome (MPS). However, its clinical value in treating with MPS induced by luteinizing-hormone releasing hormone analogue (LHRH-a) therapy of pre-/peri-menopausal breast cancer patients is still unknown.

Aim Of Study: This perspective randomised-design study is to investigate the effect and safety of cimicifuga racemosa on MPS induced by LHRH-a in breast cancer (clinical trial registered: NCT03339882). Read More

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http://dx.doi.org/10.1016/j.jep.2019.111840DOI Listing
March 2019
2 Reads
2.998 Impact Factor

Investigating the diagnostic value of quantitative parameters based on T2-weighted and contrast-enhanced MRI with psoas muscle and outer myometrium as internal references for differentiating uterine sarcomas from leiomyomas at 3T MRI.

Cancer Imaging 2019 Apr 1;19(1):20. Epub 2019 Apr 1.

The University of Sydney, Discipline of Medical Imaging and Radiation Sciences, Image Optimisation and Perception Group (MIOPeG), Sydney, NSW, Australia.

Background: Post-hysterectomy histopathological examination is currently the main diagnostic tool for differentiating uterine sarcomas from leiomyomas. This study aimed to investigate the diagnostic accuracy of preoperative quantitative metrics based on T2-weighted sequences and contrast-enhanced MRI (CE-MRI) for distinguishing uterine sarcomas from leiomyomas.

Materials And Methods: The institutional review board approved the study. Read More

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https://cancerimagingjournal.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s40644-019-0206-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444554PMC
April 2019
6 Reads

Role of MRI in uterine didelphys with co-existing endometrial carcinosarcoma.

BJR Case Rep 2018 Dec 31;4(4):20180010. Epub 2018 Oct 31.

Imaging Department, Western Health and Social Care Trust, Londonderry, UK.

A case report reviewing MRI in a patient diagnosed with carcinosarcoma and uterine didelphys following presentation with post-menopausal bleeding. Staging MRI images demonstrate the anatomical anomaly and pathological features in these co-existing conditions. This report presents an interesting case of carcinosarcoma in a uterine didelphys. Read More

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http://dx.doi.org/10.1259/bjrcr.20180010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438403PMC
December 2018
1 Read

[Social integration and gynecologic cancer screening of immigrant women in Spain].

Gac Sanit 2019 Mar 28. Epub 2019 Mar 28.

Grupo de Investigación SALBIS, León, España; Departamento de Medicina, Facultad de Medicina y Ciencias de la Salud, Universidad de Oviedo/ISPA, Oviedo, España. Electronic address:

Objective: To explore the association between immigrant status and performance of pap-smear and mammography, and to study the potential effect of social integration on that association.

Method: Secondary analysis of the National Health Survey of Spain 2012. Individual data from 8944 women aged 18-75 were analyzed. Read More

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http://dx.doi.org/10.1016/j.gaceta.2019.01.002DOI Listing
March 2019
3 Reads

The role of maternal T cell and macrophage activation in preterm birth: Cause or consequence?

Placenta 2019 Mar 9. Epub 2019 Mar 9.

Faculty of Medicine, Department of Surgery & Cancer, Imperial College, London, United Kingdom.

The role of the immune system in term (TL) and preterm labor (PTL) is unknown. Despite the fact that globally, PTL remains the most important cause of childhood mortality. Infection, typically of the fetal membranes, termed chorioamnionitis, is the best-understood driver of PTL, but the mechanisms underpinning other causes, including idiopathic and stretch-induced PTL, are unclear, but may well involve activation of the maternal immune system. Read More

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http://dx.doi.org/10.1016/j.placenta.2019.03.003DOI Listing
March 2019
4 Reads

Risk factors for failure of sentinel lymph node mapping using indocyanine green/near-infrared fluorescent imaging in endometrial cancer.

Arch Gynecol Obstet 2019 Mar 29. Epub 2019 Mar 29.

Department of Obstetrics and Gynecology, Ankara University School of Medicine, 06100, Ankara, Turkey.

Purpose: Side-specific systematic lymphadenectomy is suggested if sentinel lymph node (SLN) mapping failed in early stages endometrial cancer. This study aimed to evaluate the risk factors associated with failed mapping which may lead to modify SLN mapping technique, increase the success of SLN mapping and reduce the necessity of systematic lymphadenectomy.

Methods: Patients with early stage endometrial cancer were included in this study. Read More

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http://dx.doi.org/10.1007/s00404-019-05137-5DOI Listing
March 2019
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Letter to the Editor on 'dietary patterns and endometrial cancer: a meta-analysis'.

Eur J Cancer Prev 2019 05;28(3):243

Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.

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http://dx.doi.org/10.1097/CEJ.0000000000000445DOI Listing
May 2019
2 Reads
3.031 Impact Factor

Diagnosing Premalignant Lesions of Uterine Cervix in A ResourceConstraint Setting: A Narrative Review.

West Afr J Med 2019 Jan-Apr;36(1):48-53

Family Medicine Department, Aminu Kano Teaching Hospital, Kano Nigeria.

Cervical cancer is an important public health problem whose prevention should be integrated in all existing primary health care and women's health programmes in Nigeria and other developing countries. Cervical cancer is the second most common female malignancy in the world and it is the leading cause of cancer related deaths among women in developing countries. Furthermore, developing countries account for 80% of global deaths from cervical cancer. Read More

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March 2019
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Utero-ovarian preservation and overall survival of young women with early-stage borderline ovarian tumors.

Arch Gynecol Obstet 2019 Mar 28. Epub 2019 Mar 28.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Los Angeles County Medical Center, University of Southern California, 2020 Zonal Avenue, IRD520, Los Angeles, CA, 90033, USA.

Purpose: To examine survival of women who had uterine and ovarian preservation during surgical treatment for early-stage borderline ovarian tumors (BOTs).

Methods: The Surveillance, Epidemiology, and End Results Program was used to identify women aged < 50 years with stage I BOTs who underwent ovarian conservation at surgical treatment between 1988 and 2003. Survival outcomes were examined based on the use of concurrent hysterectomy at surgery. Read More

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http://dx.doi.org/10.1007/s00404-019-05121-zDOI Listing
March 2019
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[Surgical Treatment for Pneumopyothorax Secondary to Pancreatic Fistula].

Kyobu Geka 2019 Mar;72(3):209-212

Department of Thoracic Surgery, Sapporo Medical University, Sapporo, Japan.

A 46-year-old woman with cervical cancer with multiorgan metastasis visited our hospital. She underwent a total gastrectomy, splenectomy, distal pancreatectomy, left adrenalectomy, and left partial diaphragmatic resection. Postoperatively, she developed pleural effusion with high level of amylase secondary to a pancreatic fistula, consequently causing left-sided empyema. Read More

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March 2019
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Treatment of gynecological malignancies: long-term follow-up of health-related quality of life and healthcare costs.

J Comp Eff Res 2019 Mar 29. Epub 2019 Mar 29.

External Evaluation Unit, University of Helsinki & Helsinki University Hospital, P.O. Box 440 FI-00029 HUS, Finland.

Aim: To assess long-term health-related quality of life (HRQoL) and treatment-related costs in gynecological cancer patients, and to compare HRQoL between cancer types and to age-standardized general female population.

Materials & Methods: A prospective 8-10-year follow-up of 218 patients treated in Helsinki University Hospital in 2002-2004.

Results: The most common malignancies were uterine, ovarian and cervical cancers. Read More

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http://dx.doi.org/10.2217/cer-2018-0125DOI Listing
March 2019
1 Read