288,464 results match your criteria Uterine Cancer


Patient-derived xenograft model for uterine leiomyoma by sub-renal capsule grafting.

J Biol Methods 2018 16;5(2). Epub 2018 Apr 16.

Department of Cancer Biology and Genetics, The Comprehensive Cancer Center, Ohio State University, Columbus, OH, USA.

Uterine leiomyoma (UL) or fibroid is a benign smooth muscle tumor of the myometrium with a lifetime incidence of approximately 70%. ULs often require medical intervention due to severe symptoms such as heavy menstrual bleeding and abdominal pain. Although the most common and effective management of ULs is surgical removal, the invasive surgical procedure imposes physical and psychological burdens on the patients. Read More

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Involvement of Human Papillomaviruses in Cervical Cancer.

Front Microbiol 2018 28;9:2896. Epub 2018 Nov 28.

Department of Gynecology and Obstetrics, Qilu Hospital of Shandong University, Jinan, China.

Human papillomaviruses (HPV) are the first viruses to have been acknowledged to prompt carcinogenesis, and they are linked with cancers of the uterine cervix, anogenital tumors, and head and neck malignancies. This paper examines the structure and primary genomic attributes of HPV and highlights the clinical participation of the primary HPV serotypes, focusing on the roles that HPV-16 and 18 play in carcinogenesis. The mechanisms that take place in the progression of cervical neoplasia are described. Read More

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November 2018

Intrauterine balloon tamponade for uterine artery pseudoaneurysm: Some concerns about the procedure and indications.

Taiwan J Obstet Gynecol 2018 Dec;57(6):908

Perinatal and Maternal Center of Saitama Medical Center, Jichi Medical University, Japan.

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December 2018

Repeated pulmonary embolism with cardiac arrest after uterine artery embolization for uterine arteriovenous malformation: A case report and literature review.

Taiwan J Obstet Gynecol 2018 Dec;57(6):890-893

Department of Obstetrics and Gynecology, National Research Center of Mother and Child Health, University Medical Center, Astana, 010000, Kazakhstan.

Objective: Uterine arteriovenous malformation (AVM) is an abnormal and nonfunctional communication between uterine arteries and veins, currently managed by uterine artery embolization (UAE). Pulmonary embolism (PE) is the most severe and life-threatening complication of this procedure.

Case Report: We report a case of 27 year-old woman with heavy vaginal bleeding and abdominal pain caused by AVM. Read More

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December 2018

The outcomes of transvaginal NOTES hysterectomy in various uterine sizes.

Taiwan J Obstet Gynecol 2018 Dec;57(6):842-845

Department of Obstetrics and Gynecology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan. Electronic address:

Objectives: Natural orifice transluminal endoscopic surgery (NOTES) is an emerging technique in the area of minimally invasive procedures. Preliminary reports have confirmed transvaginal NOTES to be a safe and feasible method for performing hysterectomy and adnexal procedures. However, there are limitations regarding the feasibility of performing transvaginal NOTES hysterectomy in various uterine sizes. Read More

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December 2018

Can autologous platelet rich plasma expand endometrial thickness and improve pregnancy rate during frozen-thawed embryo transfer cycle? A randomized clinical trial.

Taiwan J Obstet Gynecol 2018 Dec;57(6):810-813

Reasearch and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address:

Objective: One of the important aspects involved in achieving optimal outcomes after assisted reproductive treatment (ART) is the endometrium. Some cycles are cancelled due to inadequate endometrial growth in ART. In this clinical trial, we evaluated the effectiveness of platelet-rich plasma (PRP) in the treatment of thin endometrium. Read More

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December 2018

Robotic myomectomy for large uterine myomas.

Taiwan J Obstet Gynecol 2018 Dec;57(6):796-800

Department of Obstetrics and Gynecology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Obstetrics and Gynecology, Hsin-Chu Br, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

Objective: To evaluate surgical outcomes and feasibility of robotic myomectomy in large uterine myomas.

Materials And Methods: This is a retrospective study for robotic myomectomies performed from October 2012 to August 2017 by a single surgeon in a tertiary care referral hospital. Demographics, diagnosis, perioperative variables, operative outcomes and complications were recorded. Read More

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December 2018

Uterine fibroids in pregnancy: prevalence, clinical presentation, associated factors and outcomes at the Limbe and Buea Regional Hospitals, Cameroon: a cross-sectional study.

BMC Res Notes 2018 Dec 13;11(1):889. Epub 2018 Dec 13.

Faculty of Health Sciences, University of Buea, P.O.Box 63, Buea, Cameroon.

Objectives: Uterine fibroids are common among the black race and associated with adverse outcomes in pregnancy. The aim of this study was to determine the prevalence, clinical presentation and maternal and foetal outcomes of birth among pregnant women with leiomyoma in two secondary care hospitals in Limbe and Buea, Cameroon.

Results: The prevalence of fibroid in pregnancy was 16. Read More

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December 2018

Decidual Emboli After Uterine Perforation.

Int J Surg Pathol 2018 Dec 14:1066896918818896. Epub 2018 Dec 14.

1 Rutgers University-New Jersey Medical School, Newark, NJ, USA.

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December 2018

The Prenatal Microbiome: A New Player for Human Health.

High Throughput 2018 Dec 11;7(4). Epub 2018 Dec 11.

CEINGE-BiotecnologieAvanzate, via G. Salvatore via G. Salvatore 486, 80145 Naples, Italy.

The last few years have featured an increasing interest in the study of the human microbiome and its correlations with health status. Indeed, technological advances have allowed the study of microbial communities to reach a previously unthinkable sensitivity, showing the presence of microbes also in environments usually considered as sterile. In this scenario, microbial communities have been described in the amniotic fluid, the umbilical blood cord, and the placenta, denying a dogma of reproductive medicine that considers the uterus like a sterile womb. Read More

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December 2018

Quantification of HPV16 E6/E7 mRNA Spliced Isoforms Viral Load as a Novel Diagnostic Tool for Improving Cervical Cancer Screening.

J Clin Med 2018 Dec 8;7(12). Epub 2018 Dec 8.

Department of Virology, Biological and Pathological Center, Centre Hospitalier Universitaire de Nice, 06200 Nice, France.

High-risk human papillomaviruses (HPVs) have been identified as the main contributors to cervical cancer. Despite various diagnostic tools available, including the predominant Papanicolaou test (Pap test), technical limitations affect the efficiency of cervical cancer screening. The aim of this study was to evaluate the diagnostic performance of spliced HPV16 E6/E7 mRNA viral loads (VL) for grade 2 or higher cervical intraepithelial neoplasia diagnosis. Read More

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December 2018
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Impact of hospital care volume on clinical outcomes of laparoscopic radical hysterectomy for cervical cancer: A systematic review and meta-analysis.

Medicine (Baltimore) 2018 Dec;97(49):e13445

Division of Gynecologic Oncology, Obstetrics and Gynecology, Irvine Medical Center, University of California, Orange, CA.

Background: In cervical cancer, the impact of hospital volume of laparoscopic radical hysterectomy (LRH) has not been investigated systematically as in ovarian cancer.The aim of this study was to investigate the impact of hospital care volume of LRH on treatment outcomes of patients with cervical cancer.

Methods: The PubMed, Embase, and Cochrane Library databases were searched with the terms "cervical cancer," "radical hysterectomy," and "laparoscopy. Read More

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December 2018

Obstructive ileus caused by metal staples 6 years after the initial surgery: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13426

Department of Colorectal Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Rationale: Complete small bowel obstruction (SBO) is a common surgical emergency often resulting from adhesive bands installed after a surgical procedure. However, SBO caused by surgical staples used in a previous operation is unusual. Herein, we report a rare case of adhesive ileus induced by surgical staples. Read More

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December 2018

Uterine microbiome-low biomass and high expectations.

Biol Reprod 2018 Dec 13. Epub 2018 Dec 13.

Igenomix Foundation, Instituto de Investigación Sanitaria Hospital Clínico (INCLIVA), Valencia, Spain.

The existence of different bacterial communities throughout the female reproductive tract has challenged the traditional view of human fetal development as a sterile event. There is still no consensus on what physiological microbiota exists in the upper reproductive tract of the vast majority of women who are not in periods of infection or pregnancy, and the role of bacteria that colonize the upper reproductive tract in uterine diseases or pregnancy outcomes is not well established. Despite published studies and advances in uterine microbiome sequencing, some study aspects-such as study design, sampling method, DNA extraction, sequencing methods, downstream analysis, and assignment of taxa-have not yet been improved and standardized. Read More

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December 2018

Recognizing Congenital Pressure Injuries: A Case Series.

Authors:
Deanna E Johnson

J Wound Ostomy Continence Nurs 2018 Dec 10. Epub 2018 Dec 10.

Deanna E. Johnson, MA, APRN, NNP-BC, CWON, Children's Hospital and Clinics, Minneapolis, Minnesota.

Background: Soft tissue injuries recognized at birth are a common occurrence and well described in the medical literature. Despite this, there has been no discussion of congenital pressure injuries. In this Clinical Challenges article, I describe 3 cases in which congenital skin injuries have occurred, all of which meet the National Pressure Ulcer Advisory Panel definition for a pressure injury and are demonstrably not the result of other etiologies. Read More

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December 2018

[Embolization of the hypogastric artery in postpartum haemorrhage. Case report].

Orv Hetil 2018 Sep;159(39):1602-1606

Szolnoki Angiográfiás és Intervenciós Központ, Avas Egészségügyi Centrum Kft. Szolnok.

Selective embolization of the hypogastric artery is nowadays commonly used for the haemostasis of gynaecological cancer patients. Also re-embolization is possible in the cases of repeated bleedings. We present this method based on the summary of three obstetrical patients in our hospital. Read More

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September 2018

Vascular responses of aortic, renal, and uterine arteries in suramin-induced preeclampsia-like syndrome in rats

Turk J Med Sci 2018 12 12;48(6):1328-1339. Epub 2018 Dec 12.

Department of Pharmacology, Faculty of Medicine, Hacettepe University, Ankara, Turkey

Background/aim: Suramin is a potent angiogenesis inhibitor in rodents and attenuates placental development in rat pregnancy. We aimed to produce preeclampsia-like syndrome by suramin administration in rats and to investigate the functional responses in aortic, renal, and uterine arteries.

Materials And Methods: Pregnant and nonpregnant wistar rats received suramin (100 mg/kg, intraperitoneal) or equal volume of saline on days 10 and 11. Read More

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December 2018

TP53 mutations as potential prognostic markers for specific cancers: analysis of data from The Cancer Genome Atlas and the International Agency for Research on Cancer TP53 Database.

J Cancer Res Clin Oncol 2018 Dec 12. Epub 2018 Dec 12.

Department of Science, The Wheatley School, Old Westbury, NY, USA.

Purpose: Mutations in the tumor suppressor gene TP53 are associated with a variety of cancers. Therefore, it is important to know the occurrence and prognostic effects of TP53 mutations in certain cancers.

Methods: Over 29,000 cases from the April 2016 release of the International Agency for Research on Cancer (IARC) TP53 Database were analyzed to determine the distribution of germline and somatic mutations in the TP53 gene. Read More

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December 2018

A rare indication of robot-assisted uretero-ureterostomy: ovarian vein syndrome.

J Robot Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Urology, PGIMER, Chandigarh, India.

Ovarian vein syndrome is a rare cause of ureteral obstruction. Most of these cases occur during pregnancy likely from the gravid uterus causing ovarian vein dilatation and valvular incompetence. Hormonal changes associated with pregnancy also affect the muscular wall of ureter, causing decrease in tone and may facilitate compression as well. Read More

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December 2018

Leiomyoma of the Foot: A Case Report.

Cureus 2018 Oct 5;10(10):e3419. Epub 2018 Oct 5.

Orthopaedics, University of Alabama at Birmingham, Birmingham, USA.

Leiomyomas are benign tumors of smooth muscle origin. They are most commonly found in the uterus, but cutaneous leiomyomas may be occasionally present in the extremities and cause pain secondary to mass effect. Few studies have reported leiomyoma of the foot, and leiomyoma of the heel is particularly rare. Read More

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October 2018

Increased α2-6 sialylation of endometrial cells contributes to the development of endometriosis.

Exp Mol Med 2018 Dec 12;50(12):164. Epub 2018 Dec 12.

Department of Korean Medical Science, School of Korean Medicine, Seoul, Republic of Korea.

Endometriosis is a disease characterized by implants of endometrial tissue outside the uterine cavity and is strongly associated with infertility. Focal adhesion of endometrial tissue to the peritoneum is an indication of incipient endometriosis. In this study, we examined the effect of various cytokines that are known to be involved in the pathology of endometriosis on endometrial cell adhesion. Read More

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December 2018

Functional Loss Defines a Targetable Subset in Leiomyosarcoma.

Oncologist 2018 Dec 12. Epub 2018 Dec 12.

Division of Bioinformatics, Department of Biomedical Informatics, College of Medicine, The Ohio State University, Columbus, Ohio, USA

Background: Soft-tissue sarcomas (STS) describe a heterogeneous group of mesenchymal tumors with limited treatment options. Targeted therapies exist for gene alterations, but their prevalence and role have not been fully described in STS. Here, we present the largest effort to characterize the frequency of homologous recombination (HR) DNA repair pathway alterations in STS subtypes and highlight the unique nature of leiomyosarcoma (LMS). Read More

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December 2018

Management of uterine sarcomas and prognostic indicators: real world data from a single-institution.

BMC Cancer 2018 Dec 13;18(1):1247. Epub 2018 Dec 13.

Department of Clinical Therapeutics, Oncology Unit, Alexandra Hospital, Vasilisis Sofias, 80, Athens, Greece.

Background: Uterine sarcomas consist a heterogeneous group of mesenchymal gynecological malignancies with unclear therapeutic recommendations and unspecific but poor prognosis, since they usually metastasize and tend to recur very often, even in early stages.

Methods: We retrospectively analyzed all female patients with uterine sarcomas treated in our institution over the last 17 years. Clinico-pathological data, treatments and outcomes were recorded. Read More

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December 2018

Anti-Inflammatory Effect of a TCM Formula Li-Ru-Kang in Rats With Hyperplasia of Mammary Gland and the Underlying Biological Mechanisms.

Front Pharmacol 2018 20;9:1318. Epub 2018 Nov 20.

College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Li-Ru-Kang (LRK), a formula of eight traditional Chinese medicines (TCM), has been used to treat hyperplasia of mammary gland (HMG) in TCM clinics. However, how LRK works in HMG patients is unclear. To explore the possible mechanisms of LRK against HMG, the network pharmacology was used to screen the potential targets and possible pathways that involved in LRK treated HMG. Read More

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November 2018

Symptoms and Health Quality After Laparoscopic and Robotic Myomectomy.

JSLS 2018 Oct-Dec;22(4)

Department of Obstetrics and Gynecology, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey.

Background And Objectives: To compare the symptom severity and health quality outcomes of women who underwent laparoscopic and robotic myomectomy.

Methods: This was a prospective nonrandomized cohort study. The Uterine Fibroid Symptom and Health Related Quality of Life Questionnaire was administered to 33 laparoscopic myomectomy and 31 robotic myomectomy patients before and year after surgery. Read More

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December 2018

Mullerian adenosarcomas of the uterine cervix with sarcomatous overgrowth.

Curr Probl Cancer 2018 Nov 30. Epub 2018 Nov 30.

Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.

Mullerian adenosarcoma with sarcomatous overgrowth (MASO) of the uterine cervix is an extremely rare variant of adenosarcoma of the genital tract associated with aggressive clinical course. We searched the PubMed and Medline databases for MASO of the cervix and we identified and reviewed eleven cases published between years 2004 and 2017. The most common clinical picture includes abnormal vaginal bleeding, postcoital bleeding, pelvic pain and foul-smelling vaginal discharge. Read More

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November 2018

The risks of cancer development in systemic lupus erythematosus (SLE) patients: a systematic review and meta-analysis.

Arthritis Res Ther 2018 Dec 6;20(1):270. Epub 2018 Dec 6.

Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, China.

Background: Although accumulating data have suggested the development of cancer in systemic lupus erythematosus (SLE) patients, these results remain inconsistent. To examine such a putative association, this analysis reports the association between SLE and the risks of 24 cancer types.

Methods: Online databases PubMed, EMBASE, and Web of Science were searched comprehensively for eligible studies, published up to 15 May 2018. Read More

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December 2018

Delivering postpartum family planning services in Nepal: are providers supportive?

BMC Health Serv Res 2018 Dec 6;18(1):948. Epub 2018 Dec 6.

Harvard T. H. Chan School of Public Health, Boston, MA, USA.

Background: Health service providers play a key role in addressing women's need for pregnancy prevention, especially during the postpartum period. Yet, in Nepal, little is known about their views on providing postpartum family planning (PPFP) services and postpartum contraceptive methods such as immediate postpartum intra-uterine devices (PPIUD). This paper explores the perspectives of different types of providers on PPFP including PPIUD, their confidence in providing PPFP services, and their willingness to share their knowledge and skills with colleagues after receiving PPFP and PPIUD training. Read More

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December 2018

Desmoplastic Small Round Cell Tumors With Atypical Presentations: A Report of 34 Cases.

Int J Surg Pathol 2018 Dec 6:1066896918817140. Epub 2018 Dec 6.

2 Mayo Clinic, Rochester, MN, USA.

Objectives: Desmoplastic small round cell tumor (DSRCT) is an aggressive round cell sarcoma that arises in the abdominal cavity/pelvis of young males. We sought to expand its clinicopathologic spectrum.

Methods: Cases of DSRCT presenting in patients >30 years of age or tumors arising outside of the abdominal cavity/pelvis were retrieved. Read More

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December 2018
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Association of uterine rupture with pregestational diabetes in women undergoing trial of labor after cesarean delivery.

J Matern Fetal Neonatal Med 2018 Dec 6:1-161. Epub 2018 Dec 6.

a Department of Obstetrics and Gynecology , Maimonides Medical Center , Brooklyn, New York , New York , USA.

Objective: To evaluate the association of pregestational diabetes with uterine rupture during a trial of labor with one prior cesarean delivery.

Study Design: A retrospective study of women undergoing trial of labor after cesarean. The study group consisted of women with pregestational diabetes, and control group was women without pregestational diabetes. Read More

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December 2018

[Study on direct economic burden and influencing factors in patients with cervical cancer and precancerous lesions].

Zhonghua Yu Fang Yi Xue Za Zhi 2018 Dec;52(12):1281-1286

Department of Epidemiology and Biostatistics, West China School of Public Health, Sichuan University, Chengdu 610041, China.

To account the direct cost of uterine cervix carcinoma treatment in China and to explore the related factors which influence the direct financial burden of the disease. Data was collected through the medical record system and telephone interviews in 14 county-level hospitals and 9 provincial and municipal hospitals from 14 provinces/municipalities enrolled in the Chinese National Health Industry Research Project in 2015. The direct financial burden of uterine cervix carcinoma treatment consisted of the direct medical cost and the direct non-medical cost of treatment in different pathological cervical cancer stages and precancerous lesions. Read More

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December 2018

Imaging Description of Extragenital Müllerian Adenosarcoma: A Case Report.

Rev Bras Ginecol Obstet 2018 Dec 12. Epub 2018 Dec 12.

Section of Obstetrics and Gynecology, Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.

Müllerian adenosarcoma is a very rare gynecological disease, comprising 5% of uterine sarcomas. Extragenital localizations are even rarer. We report a very interesting case of a 27-year-old woman complaining of pelvic pain, with a subsequent diagnosis of extragenital Müllerian adenosarcoma. Read More

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December 2018
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A Matched Analysis on the Prognostic Impact of Race on Survival Endpoints of Women with Early-Stage Endometrial Cancer.

Gynecol Obstet Invest 2018 Dec 12:1-7. Epub 2018 Dec 12.

Department of Radiation Oncology, Henry Ford Hospital, Detroit, Michigan,

Objective: To compare survival endpoints between African American (AA) and non-AA (NAA) women with endometrial carcinoma (EC) stage I-II using a robust matching analysis.

Methods And Materials: Patients were matched by stage, grade, adjuvant management (surveillance, vaginal brachytherapy or pelvic radiation treatment), age, and year of hysterectomy. Recurrence-free survival (RFS), disease-specific survival (DSS) and overall survival (OS) were calculated. Read More

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December 2018

Activin A in Mammalian Physiology.

Physiol Rev 2019 Jan;99(1):739-780

Department of Morphology, Universidade Federal de Minas Gerais , Belo Horizonte , Brazil ; Department of Experimental and Clinical Medicine, Università Politecnica delle Marche , Ancona , Italy ; Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais , Belo Horizonte , Brazil ; Department of Molecular and Developmental Medicine, Obstetrics and Gynecological Clinic, University of Siena , Siena , Italy ; and Department of Biomedical, Experimental and Clinical Sciences, Division of Obstetrics and Gynecology, University of Florence, Careggi University Hospital , Florence , Italy.

Activins are dimeric glycoproteins belonging to the transforming growth factor beta superfamily and resulting from the assembly of two beta subunits, which may also be combined with alpha subunits to form inhibins. Activins were discovered in 1986 following the isolation of inhibins from porcine follicular fluid, and were characterized as ovarian hormones that stimulate follicle stimulating hormone (FSH) release by the pituitary gland. In particular, activin A was shown to be the isoform of greater physiological importance in humans. Read More

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January 2019

Uterine tumors resembling ovarian sex-cord tumor: A case report and literature review.

J Cancer Res Ther 2018 Dec;14(Supplement):S1209-S1212

Department of Obstetrics and Gynaecology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, China.

Uterine tumors resembling ovarian sex-cord tumor (UTROSCT) are a rare, multi-phenotype sex-cord tumors, containing a structure which is characteristic with the trabecular, cord, nests, and false adenoid arrangement. In addition, CD99-positive was a basis for diagnosis of the disease. With uncertain malignant potential and relapse, these patients should be closely followed up. Read More

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December 2018
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Factor X deficiency due to a compound heterozygosis between a new mutation (Gla72Asp) in exon 2 and an already known one (Gly154Arg) in exon 5: Factor X Mar del Plata 1).

Cardiovasc Hematol Disord Drug Targets 2018 Dec 11. Epub 2018 Dec 11.

Laboratorio de Hematologia, Sanatorio Allende y Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba. Argentina.

A compound heterozygote due to the association of a new mutation (Gla72Asp) with an already known mutation (Gly154Arg) of the FX gene is reported. The proposita is a 38 year old female who had a moderate bleeding tendency (menorrhagia, epistaxis, easy bruising). The proposita has never received substitution therapy but in the occasion of a uterine biopsy. Read More

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December 2018

Selective Progesterone Receptor Modulators for the Medical Treatment of Uterine Fibroids with a Focus on Ulipristal Acetate.

Biomed Res Int 2018 24;2018:1374821. Epub 2018 Jun 24.

Universitäts-Frauenklinik Heidelberg, Germany.

Uterine fibroids are the most frequent benign tumours in women of child-bearing age. Their symptoms are diverse and the quality of life of the women affected can be significantly impaired. While treatment to date has been primarily by means of surgical intervention, selective progesterone receptor modulators (SPRMs) open up new medication-based treatment options. Read More

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June 2018
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Protective effects of saffron against zearalenone-induced alterations in reproductive hormones in female mice ().

Clin Exp Reprod Med 2018 Dec 30;45(4):163-169. Epub 2018 Nov 30.

American Center for Reproductive Medicine, Urological Institute, Cleveland Clinic, Cleveland, OH, USA.

Objective: Zearalenone (ZEA) is a mycotoxin with potent estrogenic effects. Saffron is an herbal product that has antioxidant activities. The objective of this study was to investigate the protective role of saffron against reproductive toxicity induced by ZEA in female mice. Read More

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December 2018

Bone marrow-derived stem cells contribute to regeneration of the endometrium.

Clin Exp Reprod Med 2018 Dec 30;45(4):149-153. Epub 2018 Nov 30.

Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul, Korea.

Stem cells are undifferentiated cells capable of self-renewal and differentiation into various cell lineages. Stem cells are responsible for the development of organs and regeneration of damaged tissues. The highly regenerative nature of the human endometrium during reproductive age suggests that stem cells play a critical role in endometrial physiology. Read More

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December 2018

Diagnostic Value of F-FDG PET/CT and MRI in the Preoperative Evaluation of Uterine Carcinosarcoma.

Nucl Med Mol Imaging 2018 Dec 11;52(6):445-452. Epub 2018 Oct 11.

1Department of Nuclear Medicine, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722 South Korea.

Purpose: This study aimed to compare the diagnostic value of F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) and magnetic resonance imaging (MRI) in the preoperative evaluation of uterine carcinosarcoma.

Methods: Fifty-four women with pathologically confirmed uterine carcinosarcoma who underwent preoperative FDG PET/CT and MRI from June 2006 to November 2016 were included. Pathologic findings from primary tumor lesions, para-aortic and pelvic lymph node (LN) areas, and peritoneal seeding lesions were compared with the FDG PET/CT and MRI findings. Read More

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December 2018

Successful pregnancy after uterine artery embolization for uterine arterovenous malformation: a rare case report.

Int J Womens Health 2018 21;10:745-750. Epub 2018 Nov 21.

Università degli studi di Salerno - Dipartimento di Medicina, Chirurgia e Odontoiatria "Scuola Medica Salernitana", Salerno, Italy,

Objective: This paper reports on a rare case of pregnancy after uterine artery embolization (UAE) for uterine arteriovenous malformation (AVM). Debate exists about persistence of fertility in women after UAE. Adverse effects of this technique can modify both uterine echostructure, inducing necrosis and infarction, endometrial atrophy and uterine artery rupture, and ovarian reserve, causing persistent amenorrhea. Read More

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November 2018

Asymptomatic Auto Amputation of Normal Ovary.

Indian J Surg Oncol 2018 Dec 30;9(4):565-567. Epub 2018 May 30.

Department of Obstetrics and Gynecology, El-Shatby Maternity University Hospital, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Free-floating intraperitoneal mass is rare and mostly is  related to the ovary. Asymptomatic auto amputation of the ovary is extremely rare that may be due to torsion or inflammation and usually is diagnosed incidentally . We report an interesting case of this rare pathology. Read More

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December 2018

A case report on the gallbladder fluke, (Trematoda: Dicrocoeliidae), in stray cats () in Beni-Suef, Egypt.

J Parasit Dis 2018 Dec 13;42(4):646-650. Epub 2018 Oct 13.

1Department of Parasitology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef, 62511 Egypt.

Scarce literature studying parasites, particularly helminths, of gallbladder of cats in Egypt are available. Stray cats () are widespread in Beni-Suef, Egypt. Therefore, a total of 62 stray cats were necropsied and parasitologically examined. Read More

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December 2018

Progesterone receptor integrates the effects of mutated MED12 and altered DNA methylation to stimulate RANKL expression and stem cell proliferation in uterine leiomyoma.

Oncogene 2018 Dec 11. Epub 2018 Dec 11.

Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.

Progesterone and its receptor, PR, are essential for uterine leiomyoma (LM, a.k.a. Read More

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December 2018

Individualized Homeopathic Therapy in a Case of Obesity, Dysfunctional Uterine Bleeding, and Autonomic Dystonia.

Am J Case Rep 2018 Dec 12;19:1474-1479. Epub 2018 Dec 12.

International Academy of Classical Homeopathy, University of the Aegean, Alonissos, Greece.

BACKGROUND Obesity is one of the leading causes of morbidity and mortality globally and challenging to treat because of the multifactorial etiology and presentation. Individualized homeopathy takes into account factors that led to a patient's health condition and hence may have a role in the treatment of obesity and related co-morbidities; co-morbidities that may arising from the same etiology may respond as a whole to homeopathy treatment. CASE REPORT A 39-year-old Russian female who developed multiple problems after severe emotional stress was treated with individualized classical homeopathic therapy. Read More

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December 2018

Cardiac metastasis of uterine cervical squamous cell carcinoma: A case report and review of the literature.

J Cardiol Cases 2014 Dec 2;10(6):221-225. Epub 2014 Sep 2.

Department of Cardiology, Osaka Medical College, Osaka, Japan.

A 48-year-old woman was referred to the cardiology department due to a large mobile mass in the right ventricle. The patient had undergone radical hysterectomy and bilateral salpingo-oophorectomy for a uterine squamous cell carcinoma approximately 3.5 years before. Read More

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December 2014

Case report of the successful use of Mirena levonorgestrel intrauterine system in a patient with didelphys uterus and obstructed hemivagina.

Authors:
King Cp Kives S

J Pediatr Adolesc Gynecol 2018 Dec 8. Epub 2018 Dec 8.

Section of Paediatric Gynaecology, Division of Endocrinology, Hospital for Sick Children, and the Department of Obstetrics and Gynecology, University of Toronto, 7435A-555 University Avenue, Toronto, Ontario, Canada, M5G 1X8.

Background: The Mirena levonorgestrel intrauterine system (IUS) is frequently used for menstrual suppression in adolescents with special needs. However, the presence of a uterine anomaly is generally considered a contraindication to IUS insertion, thereby excluding a potentially highly effective option for this patient population.

Case: A Mirena IUS was utilized in a medically and surgically complex special needs 14-year-old adolescent with a didelphys uterus and obstructed hemivagina. Read More

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December 2018
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Calcitonin administration improves endometrial receptivity via regulation of LIF, Muc-1 and microRNA Let-7a in mice.

J Cell Physiol 2018 Dec 8. Epub 2018 Dec 8.

Department of Reproductive Biology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Calcitonin (CT) is one of the factors affecting the embryo implantation, but its effects on the implantation window have not been fully investigated. The current study investigated the effects of CT on the endometrium receptivity by morphological study and evaluation of leukemia inhibitory factor (LIF), mucin 1 (Muc-1), and microRNA (miRNA) Let-7a in the ovarian stimulation and the normal ovarian cycle. Then the mechanism of the CT effects through the mammalian target of rapamycin (mTOR) signaling pathway was studied by using PP242. Read More

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December 2018

Cyclin-dependent kinase 9 promotes cervical cancer development via AKT2/p53 pathway.

IUBMB Life 2018 Dec 11. Epub 2018 Dec 11.

Department of Gynecologic Oncology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Aberrant activation of cyclin-dependent kinase 9 (CDK9) is widespread in human cancers. However, the underlying mechanisms of CDK9 activation and the therapeutic potential of CDK9 inhibition in cervical cancer remain largely unknown. Here, we report that CDK9 is gradually upregulated during cervical lesion progression and regulated by HPV16 E6. Read More

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December 2018

Impact of the human papillomavirus status on the development of high-grade cervical intraepithelial neoplasia in women negative for intraepithelial lesions or malignancy at the baseline: A 9-year Swedish nested case-control follow-up study.

Cancer 2018 Dec 10. Epub 2018 Dec 10.

Department of Women's and Children's Health, Karolinska University Hospital and Institute, Stockholm, Sweden.

Background: The causal relation between high-risk human papillomavirus (HPV) and cervical cancer and its precursor lesions has led to the use of sensitive HPV molecular tests for screening. This study examined the impact of the baseline HPV status on the future risk of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) among women with cytology negative for intraepithelial lesions or malignancy (NILM).

Methods: This was a nested case-control study including women with NILM baseline cytology participating in the Swedish cervical screening program in 2005-2007. Read More

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December 2018
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