135,143 results match your criteria Uterine Cancer


Detection of Circulating Tumor DNA in Patients With Leiomyosarcoma With Progressive Disease.

JCO Precis Oncol 2019 24;2019. Epub 2019 Jan 24.

Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, Massachusetts, USA.

Purpose: Leiomyosarcoma (LMS) is a soft tissue sarcoma characterized by multiple copy number alterations (CNAs) and without common recurrent single nucleotide variants. We evaluated the feasibility of detecting circulating tumor DNA (ctDNA) with next-generation sequencing in a cohort of patients with LMS whose tumor burden ranged from no evidence of disease to metastatic progressive disease.

Patients And Methods: Cell-free DNA in plasma samples and paired genomic DNA from resected tumors were evaluated from patients with LMS by ultra-low passage whole genome sequencing (ULP-WGS). Read More

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http://dx.doi.org/10.1200/PO.18.00235DOI Listing
January 2019

The Prognostic Impact of Grading in FIGO IB and IIB Squamous Cell Cervical Carcinomas.

Geburtshilfe Frauenheilkd 2019 Feb 18;79(2):198-204. Epub 2019 Feb 18.

Institute of Pathology, Division of Gynecologic Pathology, University Leipzig, Germany.

Tumor grade is one of the more controversial factors, and the data regarding its prognostic impact in squamous cell carcinoma (SCC) of the uterine cervix are controversial. The histological slides of 467 surgically treated FIGO stage IB1 to IIB cervical SCC were re-examined regarding the prognostic impact of the histological tumor grade based on the degree of keratinization (conventional tumor grade) according to the WHO recommendation on recurrence-free and overall survival as well as on the prediction of pelvic lymph node involvement. 46. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0828-7681
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http://dx.doi.org/10.1055/a-0828-7681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379165PMC
February 2019
1 Read

Performance and outcome of pelvic exenteration for gynecologic malignancies: A population-based study.

Gynecol Oncol 2019 Feb 18. Epub 2019 Feb 18.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, NY, USA.

Objective: To examine changes in performance and outcomes of pelvic exenteration for gynecologic malignancies.

Methods: This is a population-based retrospective study examining the Nationwide Inpatient Sample between 2001 and 2015. Women with cervical, uterine, vaginal, and vulvar malignancies who underwent pelvic exenteration were examined. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.02.002DOI Listing
February 2019

Minimally Invasive or Abdominal Radical Hysterectomy for Cervical Cancer.

N Engl J Med 2019 Feb 21;380(8):794. Epub 2019 Feb 21.

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February 2019

Minimally Invasive or Abdominal Radical Hysterectomy for Cervical Cancer.

N Engl J Med 2019 Feb 21;380(8):793-4. Epub 2019 Feb 21.

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February 2019

Lymphangioleiomyoma of the Uterus and Pelvic Lymph Nodes: A Report of 3 Cases, Including the Potentially Earliest Manifestation of Extrapulmonary Lymphangioleiomyomatosis.

Int J Gynecol Pathol 2019 Feb 14. Epub 2019 Feb 14.

Departments of Pathology (H.A., H.T., R.D., S.A.) Gynecology (Y.W., K.T., C.N., K.I., R.T., R.N., S.Y., T.T., A.W.), City Hospital of Toyonaka Department of Gynecology and Obstetrics, Osaka University Hospital (M.O.), Osaka, Japan.

We present 3 cases of extrapulmonary lymphangioleiomyomatosis (LAM) identified incidentally in uterine corpus and pelvic nodes resected for other reasons. One patient, a 47-yr-old female with corpus cancer, underwent a total hysterectomy and nodal dissection; the other 2 patients, aged 44 and 49 yr, underwent simple hysterectomy for corpus leiomyomas. None of the patients had evidence of tuberous sclerosis complex or any significant lesions in other organs. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000589DOI Listing
February 2019

Undifferentiated Uterine Sarcomas Represent Underrecognized High-grade Endometrial Stromal Sarcomas.

Am J Surg Pathol 2019 Feb 15. Epub 2019 Feb 15.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.

Undifferentiated uterine sarcoma is a diagnosis of exclusion with limited molecular genetic data available. Recent recognition of high-grade endometrial stromal sarcomas with diverse genotypes suggests that some tumors classified as undifferentiated uterine sarcomas may represent misdiagnosed high-grade endometrial stromal sarcomas. Archival material from 10 tumors diagnosed as undifferentiated uterine sarcomas in 2009 to 2017 were collected. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001215DOI Listing
February 2019

Mutation Frequencies in Endometrial Cancer Patients of Different Ethnicities and Tumor Grades: An Analytical Study.

Saudi J Med Med Sci 2019 Jan-Apr;7(1):16-21. Epub 2018 Dec 14.

Department of Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.

Background: Endometrial carcinoma is a predominant health problem for women worldwide. However, there is a lack of data on genetic mutation frequencies in endometrial cancer patients of different ethnicities and tumor grades.

Objective: The objective of this study is to provide data regarding mutation frequencies in endometrial cancer patients of different ethnic groups and tumor grades by analyzing large-scale cancer genomic datasets of a database. Read More

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http://dx.doi.org/10.4103/sjmms.sjmms_154_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381847PMC
December 2018

Predicting Early Response to Chemoradiotherapy for Uterine Cervical Cancer Using Intravoxel Incoherent Motion MR Imaging.

Magn Reson Med Sci 2019 Feb 19. Epub 2019 Feb 19.

Department of Radiology, Gifu University School of Medicine.

To assess if intravoxel incoherent motion (IVIM) imaging can be used to predict early response to chemoradiotherapy (CRT) in cervical cancer. IVIM imaging before and during CRT (at doses of 20 and 40 Gy) was performed in 17 patients with cervical squamous cell carcinoma. The percentage changes of IVIM parameters were significantly higher for complete remission (CR) than non-CR groups. Read More

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http://dx.doi.org/10.2463/mrms.tn.2018-0138DOI Listing
February 2019

Minimally Invasive or Abdominal Radical Hysterectomy for Cervical Cancer. Reply.

N Engl J Med 2019 02;380(8):794-795

Queensland Centre for Gynaecological Cancer Research, Brisbane, QLD, Australia.

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http://dx.doi.org/10.1056/NEJMc1816590DOI Listing
February 2019

Minimally Invasive or Abdominal Radical Hysterectomy for Cervical Cancer.

N Engl J Med 2019 02;380(8):793

Henry Ford Health System, Detroit, MI

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http://dx.doi.org/10.1056/NEJMc1816590DOI Listing
February 2019

Ovarian insufficiency and CTNNB1 mutations drive malignant transformation of endometrial hyperplasia with altered PTEN/PI3K activities.

Proc Natl Acad Sci U S A 2019 Feb 19. Epub 2019 Feb 19.

Department of Cancer Biology and Genetics, Ohio State University, Columbus, OH 43210;

Endometrioid endometrial carcinomas (EECs) carry multiple driver mutations even when they are low grade. However, the biological significance of these concurrent mutations is unknown. We explored the interactions among three signature EEC mutations: loss-of-function (LOF) mutations in , gain-of-function (GOF) mutations of phosphoinositide 3-kinase (PI3K), and exon 3 mutations, utilizing in vivo mutagenesis of the mouse uterine epithelium. Read More

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http://dx.doi.org/10.1073/pnas.1814506116DOI Listing
February 2019

Therapeutic Approaches of Resveratrol on Endometriosis via Anti-Inflammatory and Anti-Angiogenic Pathways.

Molecules 2019 Feb 13;24(4). Epub 2019 Feb 13.

Department of Medical and Surgical Specialties, Faculty of Medicine, Transilvania University of Brasov, 500019 Brasov, Romania.

Endometriosis represents a severe gynecological pathology, defined by implantation of endometrial glands and stroma outside the uterine cavity. This pathology affects almost 15% of women during reproductive age and has a wide range of consequences. In affected women, infertility has a 30% rate of prevalence and endometriosis implants increase the risk of ovarian cancer. Read More

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http://dx.doi.org/10.3390/molecules24040667DOI Listing
February 2019

MR findings of uterine PEComa in patients with tuberous sclerosis: report of two cases.

Abdom Radiol (NY) 2019 Feb 18. Epub 2019 Feb 18.

Department of Radiology, University of Tsukuba Hospital, 2-1-1 Amakubo, Tsukuba, Ibaraki, 305-8576, Japan.

Tuberous sclerosis complex (TSC), a rare autosomal dominant neurocutaneous disorder, is characterized by the presence of benign congenital tumors in multiple organs. Neoplasms with perivascular epithelioid cell differentiation (PEComas), including angiomyolipoma (AML) and lymphangioleiomyomatosis (LAM), can occur in association with TSC. This report describes two cases of uterine PEComas presenting characteristic MR imaging features reflecting pathological findings. Read More

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http://dx.doi.org/10.1007/s00261-019-01918-3DOI Listing
February 2019

Endometriosis-associated ovarian cancer: What have we learned so far?

Clin Chim Acta 2019 Feb 15. Epub 2019 Feb 15.

Division of Laboratory Medicine, Asia University Hospital, Asia University, Taichung, Taiwan; Deparment of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan; Deparment of Post-Baccalaureate Veterinary Medicine, Asia University, Taichung, Taiwan; Deparment of Nursing, Asia University, Taichung, Taiwan. Electronic address:

Endometriosis is defined as the presence of ectopic endometrial tissue outside of the uterine cavity, most commonly in the ovaries and peritoneum. It is a complex disease that is influenced by multiple factors. It is also a common gynecological disorder and affects approximately 10-15% of all women of reproductive age. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00098981193006
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http://dx.doi.org/10.1016/j.cca.2019.02.016DOI Listing
February 2019
4 Reads

Primary non-gestational uterine choriocarcinoma mimicking leiomyoma.

Pathol Int 2019 Feb 18. Epub 2019 Feb 18.

Department of Gynecologic Oncology, Kawasaki Medical School, Kurashiki, Okayama, Japan.

Uterine choriocarcinoma is a trophoblastic neoplasm that is most commonly gestational but can also be non-gestational in origin. However, primary non-gestational uterine choriocarcinoma is very rare, with only few cases having been reported. We report a case of a premenopausal woman who had initially been diagnosed with myoma delivery but who was discovered to have primary non-gestational uterine choriocarcinoma. Read More

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http://dx.doi.org/10.1111/pin.12763DOI Listing
February 2019

Primary endometrial large cell neuroendocrine carcinoma with melanocytic differentiation.

Autops Case Rep 2018 Oct-Dec;8(4):e2018041. Epub 2018 Sep 26.

Federal University of Triângulo Mineiro (UFTM), Special Pathology Discipline. Uberaba, MG, Brazil.

High-grade endometrial carcinomas are aggressive neoplasms of difficult histological classification. Neuroendocrine differentiation in endometrial carcinomas is rare. This is the report of an endometrial large cell neuroendocrine carcinoma with foci of melanocytic differentiation in a 75-year-old woman with abnormal post-menopausal uterine bleeding for 2 years. Read More

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http://dx.doi.org/10.4322/acr.2018.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360826PMC
September 2018

analysis reveals a shared immune signature in -mutated carcinomas with varying correlations to prognosis.

PeerJ 2019 11;7:e6402. Epub 2019 Feb 11.

DeepSeeq Bioinformatics, Bangalore, Karnataka, India.

Background: Sequencing studies across multiple cancers continue to reveal mutations and genes involved in the pathobiology of these cancers. Exome sequencing of oral cancers, a subset of Head and Neck Squamous cell Carcinomas (HNSCs) common among tobacco-chewing populations, revealed that ∼34% of the affected patients harbor mutations in the gene Uterine Corpus Endometrial Carcinoma (UCEC) is another cancer where ∼10% cases harbor mutations. Caspase-8, the protease encoded by gene, plays a dual role in programmed cell death, which in turn has an important role in tumor cell death and drug resistance. Read More

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http://dx.doi.org/10.7717/peerj.6402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375258PMC
February 2019

DriverML: a machine learning algorithm for identifying driver genes in cancer sequencing studies.

Nucleic Acids Res 2019 Feb 18. Epub 2019 Feb 18.

Center for Uterine Cancer Diagnosis and Therapy Research of Zhejiang Province, Women's Reproductive Health Key Laboratory of Zhejiang Province, Women's Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, China.

Although rapid progress has been made in computational approaches for prioritizing cancer driver genes, research is far from achieving the ultimate goal of discovering a complete catalog of genes truly associated with cancer. Driver gene lists predicted from these computational tools lack consistency and are prone to false positives. Here, we developed an approach (DriverML) integrating Rao's score test and supervised machine learning to identify cancer driver genes. Read More

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http://dx.doi.org/10.1093/nar/gkz096DOI Listing
February 2019
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A calcium-dependent phospholipase A2 (cPLA2) expression is regulated by MIG-6 during endometrial tumorigenesis.

Biochem Biophys Res Commun 2019 Feb 14. Epub 2019 Feb 14.

Department of Obstetrics, Gynecology & Reproductive Biology, Michigan State University, College of Human Medicine, Grand Rapids, MI, 49503, USA. Electronic address:

The ovarian steroid hormones, estrogen (E2) and progesterone (P4), are essential regulators of uterine biology. The imbalance of these ovarian steroid hormones leads to uterine diseases such as endometrial cancer, endometriosis, and infertility. Mitogen-inducible gene 6 (MIG-6) is an adaptor protein. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.02.034DOI Listing
February 2019

Cisplatin and radiation therapy in HIV-positive women with locally advanced cervical cancer in sub-Saharan Africa: A phase II study of the AIDS malignancy consortium.

Gynecol Oncol 2019 Feb 15. Epub 2019 Feb 15.

AIDS Malignancy Consortium, New York, NY, United States of America. Electronic address:

Purpose: To determine the feasibility, safety, and tolerability of concomitant chemoradiotherapy administered at standard doses in HIV-infected women with locally-advanced cervical cancer (LACC) receiving antiretroviral therapy (ART).

Patients And Methods: Eligible participants had HIV infection and untreated, histologically-confirmed, invasive carcinoma of the uterine cervix, FIGO stages IB2, IIA (if tumor >4 cm), IIB, IIIA, IIIB, or IVA and met standard eligibility criteria. Subjects were prescribed 41. Read More

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http://dx.doi.org/10.1016/j.ygyno.2019.01.023DOI Listing
February 2019

Localized high grade endometrial stromal sarcoma and localized undifferentiated uterine sarcoma: a retrospective series of the French Sarcoma Group.

Int J Gynecol Cancer 2019 Feb 16. Epub 2019 Feb 16.

Department of Medical Oncology, CHU Timone, AP-HM, Marseille, France.

Objective: High grade endometrial stromal sarcoma and undifferentiated uterine sarcomas are associated with a very poor prognosis. Although large surgical resection is the standard of care, the optimal adjuvant strategy remains unclear.

Methods: A retrospective analysis of patients with localized high grade endometrial stromal sarcoma and undifferentiated uterine sarcomas (stages I-III) treated in 10 French Sarcoma Group centers was conducted. Read More

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http://dx.doi.org/10.1136/ijgc-2018-000064DOI Listing
February 2019
2 Reads

Gene expression changes in cervical squamous cancers following neoadjuvant interventional chemoembolization.

Clin Chim Acta 2019 Feb 14. Epub 2019 Feb 14.

Medical College, Qingdao University, Qingdao 266021, Shandong, China.

Background: The efficacy of therapy for cervical cancer is related to the alteration of multiple molecular events and signaling networks during treatment. The aim of this study was to evaluate gene expression alterations in advanced cervical cancers before- and after-trans-uterine arterial chemoembolization- (TUACE).

Methods: Gene expression patterns in three squamous cell cervical cancers before- and after-TUACE were determined using microarray technique. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00098981193006
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http://dx.doi.org/10.1016/j.cca.2019.02.012DOI Listing
February 2019
2 Reads

Influence of 18F-FDG-PET/CT on staging of cervical cancer.

Nuklearmedizin 2019 Feb 15;58(1):17-22. Epub 2019 Feb 15.

Chair and Department of Electroradiology, Poznan University of Medical Science.

Aim: Cervical cancer is one of the most common cancers of the female reproductive system. The aim of the study was to assess the usefulness of the F-FDG-PET/CT study in staging of cervical cancer, with focus on the primary tumor parameters.

Material & Methods: 105 patients (mean age 56 ± 11y) with newly diagnosed cervical cancer underwent PET/CT examination which was performed 60 min after IV injection of F-FDG with a mean activity of 364 ± 75MBq. Read More

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http://dx.doi.org/10.1055/a-0809-4577DOI Listing
February 2019
1 Read

CA 125 is a better marker to differentiate endometrial cancer and abnormal uterine bleeding.

Afr Health Sci 2018 Dec;18(4):972-978

Department of Obstetrics and Gynecology, Jawaharlal Institute of Post graduate Medical Education and Research, Puducherry - 605006.

Background: Incidence of endometrial cancer in India is increasing due to lifestyle changes and obesity. As 5 year survival rate of cancer confined to uterus is good, there is need for serum tumor marker for early diagnosis. This study was designed to identify a tumor marker which differentiate endometrial carcinoma and abnormal uterine bleeding (AUB) because common presentation of endometrial carcinoma is AUB. Read More

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http://dx.doi.org/10.4314/ahs.v18i4.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354887PMC
December 2018
1 Read

Cancer statistics for African Americans, 2019.

CA Cancer J Clin 2019 Feb 14. Epub 2019 Feb 14.

Scientific Director, Surveillance Research, Surveillance and Health Services Research, American Cancer Society, Atlanta, GA.

In the United States, African American/black individuals bear a disproportionate share of the cancer burden, having the highest death rate and the lowest survival rate of any racial or ethnic group for most cancers. To monitor progress in reducing these inequalities, every 3 years the American Cancer Society provides the estimated number of new cancer cases and deaths for blacks in the United States and the most recent data on cancer incidence, mortality, survival, screening, and risk factors using data from the National Cancer Institute, the North American Association of Central Cancer Registries, and the National Center for Health Statistics. In 2019, approximately 202,260 new cases of cancer and 73,030 cancer deaths are expected to occur among blacks in the United States. Read More

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http://dx.doi.org/10.3322/caac.21555DOI Listing
February 2019

Sentinel lymph node mapping using indocyanine green in patients with uterine and cervical neoplasms: restrictions of the method.

Arch Gynecol Obstet 2019 Feb 14. Epub 2019 Feb 14.

Department of Cardiology, Institute of Mother and Child, Warsaw, Poland.

Purpose: To establish the surgical, demographic and histopathological factors associated with inaccurate sentinel lymph nodes (SLNs) identification using indocyanine green (ICG) and near-infrared (NIR) fluorescence imaging in uterine and cervical neoplasms during both open and laparoscopic surgery.

Methods: We reviewed patients with atypical endometrial hyperplasia (AEH), clinical stage I and II cervical cancer or uterine malignancies who underwent primary surgery with SLN mapping between September 2015 and January 2018. An analysis of patients' demographics, tumor factors and surgical approach was conducted. Read More

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http://dx.doi.org/10.1007/s00404-019-05063-6DOI Listing
February 2019
1 Read

Cytological features of uterine tumors resembling ovarian sex-cord tumors in liquid-based cervical cytology: a potential pitfall. Report of a unique and rare case.

Diagn Cytopathol 2019 Feb 13. Epub 2019 Feb 13.

Service of Clinical Pathology, Institute of Pathology, Lausanne University Hospital, Lausanne, Switzerland.

Uterine tumors resembling ovarian sex-cord tumors (UTROSCTs) are rare uterine neoplasms of uncertain etiology that resemble the sex cord tumors of the ovary and display a combined sex cord, epithelial, and smooth muscle immunophenotype. Most tumors are associated with a benign clinical course. We report the first cytological description of uterine UTROSCTs in liquid-based cervical cytology (LBC). Read More

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http://dx.doi.org/10.1002/dc.24153DOI Listing
February 2019
1 Read

Microvesicle Proteomic profiling of Uterine Liquid Biopsy for Ovarian Cancer Early Detection.

Mol Cell Proteomics 2019 Feb 13. Epub 2019 Feb 13.

Sheba Cancer Research Center, Chaim Sheba Medical Center, Israel.

High-grade ovarian cancer (HGOC) is the leading cause of mortality from gynecological malignancies, due to diagnosis at a metastatic stage. Current screening options fail to improve mortality due to the absence of early-stage-specific biomarkers. We postulated that a liquid biopsy, such as utero-tubal lavage (UtL), may identify localized lesions better than systemic approaches of serum/plasma analysis. Read More

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http://dx.doi.org/10.1074/mcp.RA119.001362DOI Listing
February 2019
1 Read

Delayed IL-21 treatment preferentially expands peptide-specific CD8 T cells by reducing bystander activation of T cells.

Immunotherapy 2019 Feb 14. Epub 2019 Feb 14.

Biomedicine Production Branch, National Cancer Center, Goyang, 10408 Korea.

Aim: We previously reported a simple and practical procedure to generate peptide-specific CD8 T cells using peptide and IL-2, which is applied to produce human telomerase reverse transcriptase (hTERT)-specific CD8+ T cells for clinical use. We have modified the procedure to enhance the amplification of peptide-specific CD8 T cells adding IL-21.

Materials & Methods: Using human leukocyte antigen (HLA)-A*0201-restricted cytomegalovirus/pp65-specific CD8 T cells of healthy volunteers, we optimized the culture conditions by adjusting the dose and timing of IL-21 treatment. Read More

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http://dx.doi.org/10.2217/imt-2018-0095DOI Listing
February 2019
1 Read

Reduced α-2,6 sialylation regulates cell migration in endometriosis.

Hum Reprod 2019 Feb 12. Epub 2019 Feb 12.

Département 'Développement, Reproduction et Cancer', Institut Cochin, INSERM U1016 (Professeur Batteux), Université Paris Descartes, Sorbonne Paris Cité, 22 Rue Méchain, Paris, France.

Study Question: Is endometriosis associated with aberrant sialylation patterns and what is the potential impact of such anomalies on cell migratory properties?

Summary Answer: The reduced α-2,6 sialylation patterns in the peritoneal fluid of endometriosis-affected women and in stromal and epithelial cells from endometriotic lesions could be associated with enhanced cell migration.

What Is Known Already: Endometriosis is considered to be a benign disease although, like cancer, it has the characteristic of being an invasive disease with cells that have an enhanced capacity to migrate. Aberrant sialylation has been reported in various malignancies and it has been linked to tumour invasion and metastasis. Read More

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http://dx.doi.org/10.1093/humrep/dey391DOI Listing
February 2019
1 Read

Age of Initiation of Cervical Cancer Screening-Reply.

JAMA 2019 02;321(6):612

Veterans Affairs Palo Alto Health Care System, Palo Alto, California.

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http://dx.doi.org/10.1001/jama.2018.19089DOI Listing
February 2019

Age of Initiation of Cervical Cancer Screening.

JAMA 2019 02;321(6):611-612

Department of Family Medicine, University of Calgary, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1001/jama.2018.19085DOI Listing
February 2019

Celastrol Inhibits the Growth of Ovarian Cancer Cells and .

Front Oncol 2019 28;9. Epub 2019 Jan 28.

Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Celastrol is a natural triterpene isolated from the Chinese plant Thunder God Vine with potent antitumor activity. However, the effect of celastrol on the growth of ovarian cancer cells and is still unclear. In this study, we found that celastrol induced cell growth inhibition, cell cycle arrest in G2/M phase and apoptosis with the increased intracellular reactive oxygen species (ROS) accumulation in ovarian cancer cells. Read More

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http://dx.doi.org/10.3389/fonc.2019.00002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360154PMC
January 2019
1 Read

Factors associated with deformation accuracy and modes of failure for MRI-optimized cervical brachytherapy using deformable image registration.

Brachytherapy 2019 Feb 7. Epub 2019 Feb 7.

Department of Radiation Oncology, University of California Davis Comprehensive Cancer Center, Sacramento, CA. Electronic address:

Purpose: To identify factors associated with MRI-to-CT image deformation accuracy and modes of failure for MRI-optimized intracavitary high-dose-rate treatment of locally advanced cervical cancer.

Methods And Materials: Twenty-six patients with locally advanced cervical cancer had preimplantation MRI registered and deformed to postimplantation CT images using anatomically constrained and biomechanical model-based deformable image registration (DIR) algorithms. Cervix (primary) and cervix plus 10-mm margin (secondary) were used as controlling regions of interest for deformation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15384721183068
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http://dx.doi.org/10.1016/j.brachy.2019.01.001DOI Listing
February 2019
3 Reads

Uterine Inflammatory Myofibroblastic Tumor Showing an Atypical ALK Signal Pattern by FISH and DES-ALK Fusion by RNA Sequencing: A Case Report.

Int J Gynecol Pathol 2019 Feb 7. Epub 2019 Feb 7.

Department of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio (S.Z., F.W.A.-K., C.A., M.L.C.P.-N.) University of Arizona College of Medicine Phoenix and Creighton University Phoenix College of Medicine (D.M.C.).

Inflammatory myofibroblastic tumors (IMTs) are spindle cell neoplasms of intermediate (borderline) biologic potential with tendency for local recurrence but low risk of metastasis. They affect children more than adults. The most common sites of involvement are the lung, soft tissue, peritoneum, bladder, and less commonly the gynecologic tract. Read More

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http://dx.doi.org/10.1097/PGP.0000000000000588DOI Listing
February 2019
1 Read

Prospective Detection of Germline Mutation of Fumarate Hydratase in Women With Uterine Smooth Muscle Tumors Using Pathology-based Screening to Trigger Genetic Counseling for Hereditary Leiomyomatosis Renal Cell Carcinoma Syndrome: A 5-Year Single Institutional Experience.

Am J Surg Pathol 2019 Feb 6. Epub 2019 Feb 6.

Pathology Department, University of California San Francisco.

Pathology-based screening of uterine smooth muscle tumors (uSMT) for morphology suggestive of fumarate hydratase deficiency (FH-d morphology) has been proposed as a method to identify women at increased risk for hereditary leiomyomatosis renal cell carcinoma (HLRCC) syndrome. For 5 years our clinical diagnostic practice has evaluated all women with any type of uSMT for FH-d morphology (defined, at low magnification, as staghorn shaped blood vessels and alveolar pattern edema and, at high magnification, as tumor macronucleoli surrounded by a halo and cytoplasmic eosinophilic globules) and, when present, used the pathology report to advise genetic counseling to further evaluate for HLRCC syndrome. We now report the results of this prospective screening strategy, with emphasis on the incidence and clinicopathologic features of FH-d morphology in uSMT, the rate of patient uptake of referral to genetic counseling, and the results of genetic testing for FH germline mutation. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001222DOI Listing
February 2019
1 Read

Six months response rate of combined oral medroxyprogesterone/levonorgestrel-intrauterine system for early-stage endometrial cancer in young women: a Korean Gynecologic-Oncology Group Study.

J Gynecol Oncol 2019 Jan 7. Epub 2019 Jan 7.

Department of Obstetrics and Gynecology, Ajou University School of Medicine, Suwon, Korea.

Objective: To evaluate the efficacy of combined oral medroxyprogesterone acetate (MPA)/levonorgestrel-intrauterine system (LNG-IUS) treatment and to compare the diagnostic accuracy of endometrial aspiration biopsy with dilatation & curettage (D&C) in young women with early-stage endometrial cancer (EC) who wished to preserve their fertility.

Methods: A prospective phase II multicenter study was conducted from January 2012 to January 2017. Patients with grade 1 endometrioid adenocarcinoma confined to the endometrium were treated with combined oral MPA (500 mg/day)/LNG-IUS. Read More

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http://dx.doi.org/10.3802/jgo.2019.30.e47DOI Listing
January 2019
3 Reads
1.600 Impact Factor

Asian Society of Gynecologic Oncology International Workshop 2018.

J Gynecol Oncol 2019 Jan 14. Epub 2019 Jan 14.

Department of Obstetrics and Gynecology, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea.

The Asian Society of Gynecologic Oncology International Workshop 2018 on gynecologic oncology was held in the Ajou University Hospital, Suwon, Korea on the 24th to 25th August 2018. The workshop was an opportunity for Asian doctors to discuss the latest findings of gynecologic cancer, including cervical, ovarian, and endometrial cancers, as well as the future of fertility-sparing treatments, minimally invasive/radical/debulking surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy. Clinical guidelines and position statement of Asian countries were presented by experts. Read More

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https://ejgo.org/DOIx.php?id=10.3802/jgo.2019.30.e39
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http://dx.doi.org/10.3802/jgo.2019.30.e39DOI Listing
January 2019
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Trends of uterine cancer incidence: a projection from the past to the future.

J Gynecol Oncol 2019 Jan 11. Epub 2019 Jan 11.

Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand.

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http://dx.doi.org/10.3802/jgo.2019.30.e36DOI Listing
January 2019

Minimally invasive surgery improves short-term outcomes of nerve-sparing radical hysterectomy in patients with cervical cancer: a propensity-matched analysis with open abdominal surgery.

J Gynecol Oncol 2018 Nov 27. Epub 2018 Nov 27.

Department of Gynecologic Oncology, IRCCS National Cancer Institute, Milan, Italy.

Objectives: Nerve-sparing radical hysterectomy has been implemented in order to reduce pelvic floor dysfunctions in women undergoing radical surgery for cervical cancer. Here, we aimed to investigate if the adoption of laparoscopic surgery impacts on patients' outcomes.

Methods: Data of consecutive patients affected by cervical cancer who had laparoscopic nerve-sparing radical hysterectomy were matched 1:1 with an historical cohort of patients undergoing open procedure. Read More

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http://dx.doi.org/10.3802/jgo.2019.30.e27DOI Listing
November 2018
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Trends in incidence of uterine cancer in Songkhla, Southern Thailand.

J Gynecol Oncol 2018 Nov 22. Epub 2018 Nov 22.

Epidemiology Unit, Faculty of Medicine, Prince of Songkla University Songkhla, Thailand.

Objective: To define the present incidence of uterine cancer and the trends of incidence in the future. Additional, subgroup analysis in religion and socio-demographic factors will be analyzed.

Methods: The data of uterine cancer from The Songkhla Cancer Registry between; 1989 and 2016, was extracted. Read More

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http://dx.doi.org/10.3802/jgo.2019.30.e22DOI Listing
November 2018
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The management of hydatidiform mole with lung nodule: a retrospective analysis in 53 patients.

J Gynecol Oncol 2018 Nov 23. Epub 2018 Nov 23.

Women's Reproductive Health Laboratory of Zhejiang Province, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Objective: To investigate the significance of lung nodule in hydatidiform mole, we retrospectively compared the clinical outcomes of those patients treated with different strategies.

Methods: The patients were divided into three groups: chemotherapy immediately once lung nodule was detected (group 1, n=17), delayed chemotherapy until human chorionic gonadotrophin (hCG) level met the diagnostic criteria for gestational trophoblastic neoplasia (GTN) (group 2, n=18), and hCG surveillance alone until hCG level was normalized spontaneously (group 3, n=18). The clinical parameters of these patients were collected and analyzed. Read More

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https://ejgo.org/DOIx.php?id=10.3802/jgo.2019.30.e16
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http://dx.doi.org/10.3802/jgo.2019.30.e16DOI Listing
November 2018
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The Connection of the Level of Estradiol in Serum and Obesity with the Endometrial Bleeding in Postmenopausal Women.

Open Access Maced J Med Sci 2019 Jan 13;7(1):88-91. Epub 2019 Jan 13.

University Clinic for Gynaecology and Obstetrics, Ss Cyril and Methodius University of Skopje, Skopje, Republic of Macedonia.

Background: Postmenopausis is a period that begins one year after the last menstrual period. Abnormal uterine bleeding could be of different origins.

Aim: This study aimed to determine the association of serum estrogen hormone levels and obesity with the occurrence of endometrial bleeding in post-menopausal women. Read More

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http://dx.doi.org/10.3889/oamjms.2019.079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352464PMC
January 2019
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Role of epithelial-mesenchymal transition factors in the histogenesis of uterine carcinomas.

Virchows Arch 2019 Feb 9. Epub 2019 Feb 9.

Department of Pathology, Hospices Civils de Lyon, Centre de Biologie et de Pathologie Sud, Chemin du Grand Revoyet, Université de Lyon, Université Claude Bernard Lyon I, 69495, Pierre Bénite Cedex, France.

Several subtypes of high-grade endometrial carcinomas (ECs) contain an undifferentiated component of non-epithelial morphology, including undifferentiated and dedifferentiated carcinomas and carcinosarcomas (CSs). The mechanism by which an EC undergoes dedifferentiation has been the subject of much debate. The epithelial-mesenchymal transition (EMT) is one of the mechanisms implicated in the transdifferentiation of high-grade carcinomas. Read More

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http://dx.doi.org/10.1007/s00428-019-02532-wDOI Listing
February 2019
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Sex steroid hormone receptors in bladder cancer: Usefulness in differential diagnosis and implications in histogenesis of bladder cancer.

Urol Oncol 2019 Feb 6. Epub 2019 Feb 6.

Department of Urology, Dokkyo Medical University, Tochigi, Japan.

Objective: In rare cases, differential diagnosis between bladder cancer (BC) and gynecological tract cancer (GTC) is difficult because of anatomical proximity and morphological similarity. We analyzed expression status of sex steroid hormone receptors in BC in this study. First, we investigated their usefulness as a histological marker for differential diagnosis. Read More

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http://dx.doi.org/10.1016/j.urolonc.2019.01.023DOI Listing
February 2019
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[MSI Metastatic solid tumors treatment and immunotherapies].

Bull Cancer 2019 Feb 5;106(2):143-150. Epub 2019 Feb 5.

Assistance publique-Hôpitaux de Paris, UPEC, hôpital Henri-Mondor, département d'oncologie médicale, 94010 Créteil, France; Centre hospitalier intercommunal de Créteil, département d'oncologie médicale, 94010 Créteil, France. Electronic address:

Checkpoints inhibitors are known to induce striking tumor responses in advanced MSI colorectal cancers, which used to be related to a poor clinical outcome. The incidence of the MSI phenotype is highly heterogeneous across non-colorectal cancers. The highest incidence rates are found in endometrioid forms of uterine cancers and in gastric tumors (20 to 40 % and 10 to 33 %, respectively). Read More

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http://dx.doi.org/10.1016/j.bulcan.2019.01.008DOI Listing
February 2019
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Investigation of Safety Profile of Four Species and of Kaurenoic Acid by /Microsome Test.

Evid Based Complement Alternat Med 2019 10;2019:7631531. Epub 2019 Jan 10.

Laboratory of Research in Applied Microbiology (LAPEMA), University of Franca, Avenida Dr. Armando Salles de Oliveira 201, 14404-600 Franca, SP, Brazil.

Trees of the genus are native to the tropical regions of Latin America and Western Africa. sp is widely used as a popular medicine and it has various ethnopharmacological indications, including gonorrhea, bronchitis, asthma, skin ulcers, ulcers, sore throat, uterine infections, general inflammations, cancer, and leishmanioses. Kaurenoic acid is a naturally occurring diterpene found in and has been used as an anti-inflammatory, treatment of ulcer, leishmaniasis, and cancer. Read More

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http://dx.doi.org/10.1155/2019/7631531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348810PMC
January 2019
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Suprarenal lymph node dissection by the Kocher maneuver in the surgical management of ovarian cancer.

Int J Gynecol Cancer 2019 Feb 7. Epub 2019 Feb 7.

Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea.

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http://dx.doi.org/10.1136/ijgc-2018-000093DOI Listing
February 2019
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Emerging cancer trends among young adults in the USA: analysis of a population-based cancer registry.

Lancet Public Health 2019 Feb 1. Epub 2019 Feb 1.

Surveillance and Health Services Research Program, American Cancer Society, Atlanta, GA, USA. Electronic address:

Background: Cancer trends in young adults, often under 50 years, reflect recent changes in carcinogenic exposures, which could foreshadow the future overall disease burden. Previous studies reported an increase in early onset colorectal cancer, which could partly reflect the obesity epidemic. We examined age-specific contemporary incidence trends in the USA for 30 common cancers, including 12 obesity-related cancers. Read More

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http://dx.doi.org/10.1016/S2468-2667(18)30267-6DOI Listing
February 2019
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