141,649 results match your criteria Uterine Cancer


An immune competent orthotopic model of endometrial cancer with metastasis.

Heliyon 2020 May 27;6(5):e04075. Epub 2020 May 27.

Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, Grand Rapids MI, USA.

Endometrial cancer is the most common gynecologic malignancy in the U.S. with metastatic disease remaining the major cause of patient death. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e04075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260377PMC

Tumor Handling of Early-stage Cervical Cancer: A Literature Analysis of Villoglandular Adenocarcinoma of the Cervix.

Anticancer Res 2020 Jun;40(6):3049-3053

Department of Obstetrics and Gynecology, University of Erlangen, Erlangen, Germany.

Background/aim: Recent studies have demonstrated the inferior overall survival outcomes of patients with early-stage cervical cancer who undergo minimally invasive surgery (MIS). One possible explanation for these unexpected results is intraoperative tumor manipulation.

Materials And Methods: Considering this hypothesis, we have reviewed the literature on the oncological outcomes of patients with villoglandular adenocarcinoma (VGA) of the cervix, an uncommon variant of cervical cancer that has an excellent prognosis. Read More

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http://dx.doi.org/10.21873/anticanres.14285DOI Listing

Typical ultrasound features of various endometrial pathology described using the International Endometrial Tumor Analysis (IETA) terminology in women with abnormal uterine bleeding.

Ultrasound Obstet Gynecol 2020 Jun 2. Epub 2020 Jun 2.

Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium.

Objective: To describe the ultrasound features of different endometrial and other intracavitary pathologies in pre- and postmenopausal women presenting with abnormal uterine bleeding using the International Endometrial Tumor Analysis (IETA) terminology.

Methods: Prospective observational multicenter study of 2856 consecutive women presenting with abnormal uterine bleeding. Unenhanced ultrasonography with color Doppler was performed in all cases and fluid instillation sonography in 1857. Read More

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http://dx.doi.org/10.1002/uog.22109DOI Listing

Analysis of Conization Results in Patients undergoing Hysterectomy for Uterine Adenocarcinoma.

Rev Bras Ginecol Obstet 2020 May 29;42(5):266-271. Epub 2020 May 29.

Department of Surgery, Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brazil.

Objective:  To observe if the histopathological result of a conization performed after cervical adenocarcinoma in situ diagnosis is compatible with the histopathological analysis of a subsequent hysterectomy.

Methods:  The present descriptive and observational research consisted of the analysis of the medical records of 42 patients who were diagnosed with in situ adenocarcinoma postconization. The analysis consisted of whether there was compatibility between the histopathological reports of conization and hysterectomy and if there was an association between adenocarcinoma in situ and another neoplasia (squamous disease). Read More

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http://dx.doi.org/10.1055/s-0040-1709191DOI Listing

Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming.

Nat Commun 2020 Jun 1;11(1):2717. Epub 2020 Jun 1.

Sidney Kimmel Comprehensive Cancer Center and Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, 21205, USA.

Somatic inactivating mutations of ARID1A, a SWI/SNF chromatin remodeling gene, are prevalent in human endometrium-related malignancies. To elucidate the mechanisms underlying how ARID1A deleterious mutation contributes to tumorigenesis, we establish genetically engineered murine models with Arid1a and/or Pten conditional deletion in the endometrium. Transcriptomic analyses on endometrial cancers and precursors derived from these mouse models show a close resemblance to human uterine endometrioid carcinomas. Read More

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http://dx.doi.org/10.1038/s41467-020-16416-0DOI Listing

Pivotal role of the transcriptional co-activator YAP in trophoblast stemness of the developing human placenta.

Proc Natl Acad Sci U S A 2020 Jun 1. Epub 2020 Jun 1.

Department of Obstetrics and Gynaecology, Reproductive Biology Unit, Medical University of Vienna, A-1090 Vienna, Austria;

Various pregnancy complications, such as severe forms of preeclampsia or intrauterine growth restriction, are thought to arise from failures in the differentiation of human placental trophoblasts. Progenitors of the latter either develop into invasive extravillous trophoblasts, remodeling the uterine vasculature, or fuse into multinuclear syncytiotrophoblasts transporting oxygen and nutrients to the growing fetus. However, key regulatory factors controlling trophoblast self-renewal and differentiation have been poorly elucidated. Read More

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http://dx.doi.org/10.1073/pnas.2002630117DOI Listing

Uterine Fibroids Increase the Risk of Thyroid Cancer.

Int J Environ Res Public Health 2020 May 28;17(11). Epub 2020 May 28.

Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung 404, Taiwan.

Objectives: The formation of uterine fibroids (UF) is potentially linked to the development of thyroid cancer through a common factor: female sex hormones.

Methods: We conducted a nationwide population-based cohort study to determine whether Taiwanese women with UF have an increased risk of thyroid cancer. The data of both the UF and control groups were derived from the National Health Insurance Research Database (NHIRD) of Taiwan. Read More

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http://dx.doi.org/10.3390/ijerph17113821DOI Listing

Expression of nuclear progesterone receptors (nPRs), membrane progesterone receptors (mPRs) and progesterone receptor membrane components (PGRMCs) in the human endometrium after 6 months levonorgestrel low dose intrauterine therapy.

J Steroid Biochem Mol Biol 2020 May 29:105701. Epub 2020 May 29.

Research group for Experimental and Clinical Pharmacology, Department of Medical Biology, The Arctic University of Norway, Tromsø, Norway; Clinical Pharmacology, Department of Laboratory Medicine, University Hospital of North Norway, Tromsø, Norway. Electronic address:

The classical steroid receptors (nuclear receptors), including those for progesterone (nPRs), are thoroughly characterized. The knowledge about so-called non-genomic effects, which are mediated by extra-nuclear initiated signals, has increased immensely the last decades. In a previous clinical study of endometrial hyperplasia, we observed that the antiproliferative progestin effect persisted after 3 months treatment with levonorgestrel (LNG) intrauterine system (IUS) even with a complete downregulation of nPRs. Read More

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http://dx.doi.org/10.1016/j.jsbmb.2020.105701DOI Listing

Risk of cervical lesions in high-risk HPV positive women with normal cytology: a retrospective single-center study in China.

Infect Agent Cancer 2020 21;15:34. Epub 2020 May 21.

1Department of Gynecology, Qilu Hospital of Shandong University, Jinan, China.

Background: To investigate high-risk HPV (hr-HPV) genotype distributions and the association between hr-HPV infection with severity of the cervical lesions in women with normal cytology.

Methods: In this cross-sectional study, the result of the hr-HPV test and biopsy of colposcopy of women with normal cytology from January 2012 to January 2019 were analyzed. The detection rate of high-grade squamous intraepithelial lesion (HSIL) and cervical cancer were calculated among different hr-HPV genotypes, viral load group, and age groups. Read More

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http://dx.doi.org/10.1186/s13027-020-00291-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240930PMC

Trends in cancer incidence in Uruguay: 2002 -2015.

Colomb Med (Cali) 2019 Dec 30;50(4):224-238. Epub 2019 Dec 30.

Universidad de la República, Facultad de Medicina, Departamento de Métodos Cuantitativos. Montevideo, Uruguay.

Background: Uruguay is the south American country which has the highest cancer incidence and mortality rates. The National Cancer Registry collects data on cancer cases nationwide since 1989 and has reached high quality standards in the last decades. This is the first report on incidence trends. Read More

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http://dx.doi.org/10.25100/cm.v50i4.4212DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232944PMC
December 2019

Executive summary of the American Radium Society® Appropriate Use Criteria for management of uterine carcinosarcoma.

Gynecol Oncol 2020 May 29. Epub 2020 May 29.

University of California San Diego, San Diego, CA, United States of America.

Objective: Uterine carcinosarcomas (UCS) represent a rare but aggressive subset of endometrial cancers, comprising <5% of uterine malignancies. To date, limited prospective trials exist from which evidence-based management of this rare malignancy can be developed.

Methods: The American Radium Society Appropriate Use Criteria presented in this manuscript are evidence-based guidelines developed by a multidisciplinary expert panel for management of women with UCS. Read More

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http://dx.doi.org/10.1016/j.ygyno.2020.04.683DOI Listing

Women's attitudes and understanding of cervical cancer and the new National Cervical Screening Program.

Health Promot J Austr 2020 May 31. Epub 2020 May 31.

Mackay Clinical School, College of Medicine and Dentistry, James Cook University, Mackay, QLD, 4740, Australia.

The new National Cervical Screening Program (NCSP) has recently been implemented. Little research is available on women's attitudes towards the program. This study aims to quantitatively assess Australian women's understanding and attitudes towards the new guidelines and their barriers to screening. Read More

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http://dx.doi.org/10.1002/hpja.365DOI Listing

Molecular and pathological basis of HPV-negative cervical adenocarcinoma seen in a global study.

Int J Cancer 2020 May 31. Epub 2020 May 31.

DDL diagnostic Laboratory, Rijswijk, The Netherlands.

International surveys find HPV-negativity in up to 30% of cervical adenocarcinomas. We investigated the pathological diagnosis by expert consensus with immunohistochemistry and presence of somatic mutations in recognised tumour genes in HPV-positive and negative cervical adenocarcinomas (CADC). A sample was selected of 45 paraffin-embedded cervical blocks diagnosed locally as usual cervical adenocarcinoma from a global study. Read More

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http://dx.doi.org/10.1002/ijc.33124DOI Listing

Combination of sentinel lymph node mapping and uterine frozen section examination to reduce side-specific lymphadenectomy rate in endometrial cancer: a Turkish Gynecologic Oncology Group study (TRSGO-SLN-002).

Int J Gynecol Cancer 2020 May 30. Epub 2020 May 30.

Obstetrics and Gynecology, Koc University School of Medicine, Istanbul, Turkey.

Objective: This study aimed to find out whether side-specific pelvic lymphadenectomy can be omitted without compromising diagnostic efficacy according to "reflex frozen section" analysis of the uterus in case of sentinel lymph node (SLN) mapping failure.

Methods: Patients who underwent surgery for endometrial cancer with an SLN algorithm were stratified as low-risk or high-risk according to the uterine features on the final pathology reports. Two models for low-risk patients were defined to omit side-specific pelvic lymphadenectomy: strategy A included patients with endometrioid histology, grade 1-2, and <50% myometrial invasion irrespective of the tumor diameter; strategy B included all factors of strategy A with the addition of tumor diameter ≤2 cm. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001353DOI Listing

A systematic review of the psychosocial impact of fibroids before and after treatment.

Am J Obstet Gynecol 2020 May 28. Epub 2020 May 28.

Johns Hopkins School of Medicine, Department of Gynecology and Obstetrics, Division of Reproductive Sciences & Women's Health Research. Electronic address:

Objective: Despite the high prevalence of uterine fibroids, the psychosocial impact of fibroids has not been evaluated across different quality of life indicators and compared to other chronic conditions. Here we rigorously analyzed available evidence pertaining to the psychosocial burden of uterine fibroids in premenopausal women and compare validated quality of life and symptom scores before and after treatment.

Data Sources: We searched PubMed, PsycINFO, ClinicalTrials. Read More

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http://dx.doi.org/10.1016/j.ajog.2020.05.044DOI Listing

Clonal lineage from normal endometrium to ovarian clear cell carcinoma through ovarian endometriosis.

Cancer Sci 2020 May 30. Epub 2020 May 30.

Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, 951-8510, Japan.

Clear cell carcinoma of the ovary is thought to arise from endometriosis. Additionally, retrograde menstruation of shed endometrium is considered the origin of endometriosis. However, little evidence supports cellular continuity from uterine endometrium to clear cell carcinoma through endometriosis at the genomic level. Read More

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http://dx.doi.org/10.1111/cas.14507DOI Listing

TCGA Classification of Endometrial Cancer: the Place of Carcinosarcoma.

Pathol Oncol Res 2020 May 29. Epub 2020 May 29.

Gynecology and Obstetrics Unit, Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Via Sergio Pansini, 5, 80131, Naples, Italy.

In 2013, The Cancer Genome Atlas (TCGA) Research Network found four novel prognostic subgroups of endometrial carcinoma: POLE/ultramutated (POLE), microsatellite-instable/hypermutated (MSI), copy-number-low/TP53-wild-type (CNL), and copy-number-highTP53-mutant (CNH). However, poor is known regarding uncommon histotypes of endometrial cancer. We aimed to assess the genetic profile of uterine carcinosarcoma (UCS) on the light of these findings. Read More

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http://dx.doi.org/10.1007/s12253-020-00829-9DOI Listing

"Katz activities of daily living disability in older cancer survivors by age, stage, and cancer type".

J Cancer Surviv 2020 May 30. Epub 2020 May 30.

Physical Therapy Department, University of Michigan - Flint, 303 East Kearsley Street, 2157 William S. White Building, Flint, MI, 48502-1950, USA.

Purpose/objective: The purpose of this study was to describe ADL impairments using the Katz ADL Index by cancer type, stage, and age in older cancer survivors.

Methods: Cross-sectional data from cohorts 9-14 (year 2006-2013) of the Surveillance, Epidemiology and End Results national cancer registry and Medicare Health Outcomes Survey linkage were used to describe ADL performance using the Katz ADL Index. Mean Katz scores and frequency of ADL disability were reported across cancer types for all eight cancers (colon, lung, breast, prostate, bladder, kidney, non-Hodgkin's lymphoma, uterine) and by stage and age for the four large cancers (colon, lung, breast, prostate). Read More

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http://dx.doi.org/10.1007/s11764-020-00891-xDOI Listing

Ancestry-specific predisposing germline variants in cancer.

Genome Med 2020 May 29;12(1):51. Epub 2020 May 29.

Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

Background: Distinct prevalence of inherited genetic predisposition may partially explain the difference of cancer risks across ancestries. Ancestry-specific analyses of germline genomes are required to inform cancer genetic risk and prognosis of diverse populations.

Methods: We conducted analyses using germline and somatic sequencing data generated by The Cancer Genome Atlas. Read More

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http://dx.doi.org/10.1186/s13073-020-00744-3DOI Listing

Pan‑cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS‑CoV‑2 infection leading to COVID-19.

Int J Oncol 2020 May 26. Epub 2020 May 26.

Biosciences, College of Health and Life Sciences, Brunel University London, Uxbridge UB8 3PH, UK.

Severe acute respiratory syndrome (SARS) coronavirus‑2 (SARS‑CoV2) is the cause of a new disease (COVID‑19) which has evolved into a pandemic during the first half of 2020. Older age, male sex and certain underlying diseases, including cancer, appear to significantly increase the risk for severe COVID‑19. SARS‑CoV‑2 infection of host cells is facilitated by the angiotensin‑converting enzyme 2 (ACE‑2), and by transmembrane protease serine 2 (TMPRSS2) and other host cell proteases such as cathepsin L (CTSL). Read More

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http://dx.doi.org/10.3892/ijo.2020.5071DOI Listing

The upper limit of optimal tumor size in patients with FIGO 2018 stage IB2 cervical cancer undergoing radical hysterectomy.

Int J Gynecol Cancer 2020 May 28. Epub 2020 May 28.

Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.

Objective: Patients who undergo radical hysterectomy may require postoperative adjuvant radiotherapy, and all efforts should be made to reduce dual therapy in such patients. The aim of this study was to determine the optimal upper limit of tumor size in patients with International Federation of Gynecology and Obstetrics (FIGO) stage IB2 cervical cancer who undergo radical hysterectomy.

Methods: We retrospectively reviewed the records of 114 patients with FIGO 2018 stage IB2 cervical cancer who underwent primary surgery either with (n=55) or without (n=59) adjuvant radiotherapy from June 2004 to December 2018. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001271DOI Listing

Influence of uterine corpus invasion on prognosis in stage IA2-IIB cervical cancer: A multicenter retrospective cohort study.

Gynecol Oncol 2020 May 26. Epub 2020 May 26.

Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. Electronic address:

Objective: To determine the associations between the presence and depth of uterine corpus invasion and survival in patients with cervical cancer.

Methods: Clinical data of patients with stage IA2-IIB cervical cancer who underwent radical hysterectomy between 2004 and 2016 were retrospectively reviewed. Uterine corpus invasion was identified from a review of uterine pathology. Read More

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http://dx.doi.org/10.1016/j.ygyno.2020.05.005DOI Listing

[Preliminary study of the clinical value of colposcopy in diagnosing vagina invasion in cervical cancer].

Zhonghua Fu Chan Ke Za Zhi 2020 May;55(5):322-326

Department of Gynecologic Oncology, Xuzhou Hospital Affiliated to Jiangsu University/Xuzhou Cancer Hospital, Xuzhou 221000, China.

To explore the preliminary clinical values of colposcopy in the diagnosis of vaginal invasion in cervical cancer. A retrospective review of the clinical records of patients (31 cases) with cervical cancer treated in Xuzhou Cancer Hospital from April 2015 to August 2019. For those with early-stage cervical cancer and the vagina invasion being difficult to be determined, those with advanced cervical cancer and the scope of vaginal invasion being difficult to be judged, and those with obvious vaginal tumor and underexposed cervix or inconspicuous cervical lesion and the primary location needing to be identified, colposcopy-guided vaginal and cervix biopsy were performed before treatment. Read More

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http://dx.doi.org/10.3760/cma.j.cn112141-20200211-00093DOI Listing

Fumarate hydratase c.914T > C (p.Phe305Ser) is a pathogenic variant associated with hereditary leiomyomatosis and renal cell cancer syndrome.

Mol Genet Genomic Med 2020 May 28:e1293. Epub 2020 May 28.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York City, NY, USA.

Background: Hereditary leiomyomatosis and renal cell cancer syndrome (HLRCC), caused by heterozygous germline pathogenic variants in the FH, confers an increased risk for cutaneous and uterine leiomyomas and renal cancer.

Methods: About 13,722 advanced cancer patients, including 560 with renal cell carcinoma, had germline analysis performed in the context of tumor-normal sequencing under an IRB approved protocol.

Results: We report two unrelated individuals with early onset kidney cancer who both carried the c. Read More

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http://dx.doi.org/10.1002/mgg3.1293DOI Listing

Efficacy of a novel orally active SERD AZD9496 against hormone dependent post-menopausal breast cancer depends on inhibition of cellular aromatase activity.

J Steroid Biochem Mol Biol 2020 May 24:105697. Epub 2020 May 24.

Department of Pharmaceutical Sciences, West Coast University, Los Angeles, CA, 90004, United States; Department of Pharmacology, United States. Electronic address:

Treatment of hormone sensitive breast cancer tumors with endocrine therapy such as antiestrogens or aromatase inhibitors has improved the outcome significantly. Studies including our own have shown that downregulation of ERα with pure antiestrogen fulvestrant in combination with aromatase inhibitors may prolong responsiveness of the tumors to endocrine therapy. Fulvestrant has been studied as second line or first line treatment for post-menopausal hormone receptor positive breast cancers as a single agent or in combination with AIs. Read More

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http://dx.doi.org/10.1016/j.jsbmb.2020.105697DOI Listing

Cowden syndrome complicated by schizophrenia: A first clinical report.

Eur J Med Genet 2020 May 24:103959. Epub 2020 May 24.

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.

Patients with Cowden syndrome exhibit mucocutaneous lesions, hamartomatous polyposis of the gastrointestinal tract, and macrocephaly, often complicated by malignant tumors, such as breast, thyroid, and uterine cancers. Autism spectrum and epilepsy have been known as neuropsychiatric symptoms associated with Cowden syndrome; however, to the best of our knowledge, there is no report on cases complicated by schizophrenia. Here, we report a first case of Cowden syndrome complicated by schizophrenia. Read More

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http://dx.doi.org/10.1016/j.ejmg.2020.103959DOI Listing

Clinical management of abnormal Pap tests: differences between US and Korean guidelines.

J Pathol Transl Med 2020 May 15;54(3):213-219. Epub 2020 Apr 15.

Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University College of Medicine, Seoul, Korea.

Cervical cancer has been the most common gynecological cancer in Korea but has become a preventable disease with regular screening and proper vaccination. If regular screening is provided, cervical cancer does not progress to more than carcinoma in situ, due to its comparatively long precancerous duration (years to decades). In 2012, the American Society for Colposcopy and Cervical Pathology published guidelines to aid clinicians in managing women with abnormal Papanicolaou (Pap) tests, and they soon became the standard in the United States. Read More

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http://dx.doi.org/10.4132/jptm.2020.03.11DOI Listing

Factors that Affected Women Undergoing Cryotherapy Following Cancer Screening with Visual Inspection of the Cervix Using Acetic Acid Method.

Asian Pac J Cancer Prev 2020 May 1;21(5):1423-1429. Epub 2020 May 1.

Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr Sardjito General Hospital, Yogyakarta, Indonesia.

Background: The Indonesian government has applied the cancer "see and treat" method which involves a visual inspection using acetic acid (VIA), followed by a cryotherapy procedure, to reduce the incidence of cervical cancer. However, compliance with the program is still low in the targeted population. This study aims to see what factors influence women to receive cryotherapy treatment if they have positive VIA result. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.5.1423DOI Listing

The Diagnostic Accuracy of an Intraoperative Frozen Section Analysis and Imprint Cytology of Sentinel Node Biopsy Specimens from Patients with Uterine Cervical and Endometrial Cancer: a Retrospective Observational Study.

Pathol Oncol Res 2020 May 26. Epub 2020 May 26.

Department of Obstetrics and Gynecology, Osaka Medical College, 2-7, Daigaku-machi, Takatsuki, Osaka, 569-8686, Japan.

Sentinel node biopsy (SNB) may be a decision-making tool for function preservation surgery, including radical trachelectomy and ovary preservation in the treatment of cervical and endometrial cancer. The intraoperative diagnosis is important for guiding treatment decisions for patients with these conditions. Three hundred seventy-one patients with cervical and endometrial cancer received SNB with an intraoperative frozen section analysis and imprint cytology. Read More

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http://dx.doi.org/10.1007/s12253-020-00822-2DOI Listing

Impact of different adjuvant treatment approaches on survival in stage III endometrial cancer: A population-based study.

Eur J Cancer 2020 May 23;133:104-111. Epub 2020 May 23.

Department of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address:

Background: Patients with International Federation of Gynaecology and Obstetrics (FIGO) stage III endometrial cancer (EC) have a substantial risk of adverse outcomes. After surgery, adjuvant therapy is recommended with external beam radiotherapy (EBRT), chemotherapy (CT) or both EBRT and CT. Recent trials suggest that EBRT + CT is superior to EBRT or CT alone but also results in more toxicity. Read More

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http://dx.doi.org/10.1016/j.ejca.2020.04.012DOI Listing

Does muscle invasive bladder cancer following pelvic radiotherapy portend worse prognosis? A seer-based study.

Cancer Treat Res Commun 2020 May 23;24:100177. Epub 2020 May 23.

Tulane University School of Medicine, Department of Urology, 1430 Tulane Ave, New Orleans, LA 70112, USA. Electronic address:

Background: Although emerging evidence demonstrates increased risk of secondary bladder cancer following pelvic radiotherapy, the aggressiveness of these tumors is not well-characterized.

Materials And Methods: A search of the Surveillance, Epidemiology, and End Results (SEER) 18 Database, identified 25,734 patients diagnosed with bladder cancer following definitive therapy for previous pelvic malignancy. Kaplan-Meier curve analyses were utilized to determine overall survival with significance set at p<0. Read More

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http://dx.doi.org/10.1016/j.ctarc.2020.100177DOI Listing

Deletion of atypical chemokine receptor 3 (ACKR3) increases immune cells at the fetal-maternal interface.

Placenta 2020 Apr 22;95:18-25. Epub 2020 Apr 22.

Department of Cell Biology and Physiology, 111 Mason Farm Road, 6312B Medical Biomolecular Research Building, CB# 7545, Chapel Hill, NC, 27599, USA; Department of Genetics, 111 Mason Farm Road, 6312B Medical Biomolecular Research Building, CB# 7545, Chapel Hill, NC, 27599, USA; Lineberger Comprehensive Cancer Center, 111 Mason Farm Road, 6312B Medical Biomolecular Research Building, CB# 7545, Chapel Hill, NC, 27599, USA. Electronic address:

Establishment of immune cell populations and adaptations in immune cells are critical aspects during pregnancy that lead to protection of the semi-allogenic fetus. Appropriate immune cell activation and trophoblast migration are regulated in part by chemokines, the availability of which can be fine-tuned by decoy receptors. Atypical chemokine receptor 3 (ACKR3), previously named C-X-C chemokine receptor 7 (CXCR7), is a chemokine decoy receptor expressed in placenta, but little is known about how this receptor affects placental development. Read More

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http://dx.doi.org/10.1016/j.placenta.2020.04.007DOI Listing

Unexpected tumor-to-tumor metastasis of synovial sarcoma within leiomyoma: A case report and literature review.

J Obstet Gynaecol Res 2020 May 25. Epub 2020 May 25.

Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

A tumor metastasis within another tumor is known as tumor-to-tumor metastasis (TTM). We report a 43-year-old woman who presented with hypermenorrhea and an abdominal mass. She had history of a soft tissue tumor on her left ankle at 38 years of age. Read More

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http://dx.doi.org/10.1111/jog.14298DOI Listing

An analysis of operating time over the years for robotic-assisted surgery in gynecology and gynecologic oncology.

J Robot Surg 2020 May 25. Epub 2020 May 25.

Department of Gynaecological Oncology, Amrita Institute of Medical Sciences, Kochi, Kerala, 682041, India.

Robotic-assisted surgery has a shorter learning curve enabling the surgeons to do complex surgeries in a minimally invasive way. This study analyzed how the time taken for robotic-assisted procedures in gynecology and gynecologic oncology has changed over the years in a university teaching institution. Details were taken from a prospectively maintained electronic database after obtaining permission from the hospital ethics committee. Read More

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http://dx.doi.org/10.1007/s11701-020-01094-3DOI Listing

USEFUL PELVIC RETROPERITONEAL NEURO-ANATOMY FOR BENIGN GYNECOLOGIC SURGERY - A CADAVERIC DISSECTION.

J Minim Invasive Gynecol 2020 May 22. Epub 2020 May 22.

Department of Gynecological Surgery, Vita Batel Hospital, Curitiba, Brazil.

Objective: Knowledge of retroperitoneal anatomy is particularly important in order to facilitate the surgical procedure and reduce the number of complications. The objective of this video is to demonstrate pelvic neuroanatomical structures and their relationships in the pelvic side wall and the presacral space in a laparoscopic cadaveric dissection.

Design: Case report (anatomical study). Read More

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http://dx.doi.org/10.1016/j.jmig.2020.05.013DOI Listing

Multimodality adjuvant therapy and survival outcomes in stage I-IV uterine carcinosarcoma.

Int J Gynecol Cancer 2020 May 23. Epub 2020 May 23.

Gynecologic Oncology, NewYork-Presbyterian Brooklyn Methodist Hospital, Brooklyn, New York, USA.

Objectives: Uterine carcinosarcoma is a rare, aggressive form of uterine cancer with a high recurrence rate and poor survival at all stages. We sought to evaluate the outcomes of patients treated with chemotherapy versus a combination of chemotherapy and radiation (chemoradiation) to determine survival.

Methods: A multicenter retrospective analysis of patients with stage I-IV carcinosarcoma was conducted from January 2000 to December 2017. Read More

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http://dx.doi.org/10.1136/ijgc-2020-001315DOI Listing

Basic social resource needs screening in the gynecologic oncology clinic: a quality improvement initiative.

Am J Obstet Gynecol 2020 May 17. Epub 2020 May 17.

The Kelly Gynecologic Oncology Service, Department of Gynecology and Obstetrics, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Background: Social determinants of health are known to contribute to disparities in health outcomes. Routine screening for basic social needs is not a part of standard care, though the association with those needs and increased healthcare utilization and poor compliance with guideline-directed care is well established.

Objectives: We aimed to assess the prevalence of basic social resource needs identified through a quality improvement initiative in a gynecologic oncology outpatient clinic. Read More

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http://dx.doi.org/10.1016/j.ajog.2020.05.028DOI Listing

Latest Advances in the Laparoscopic Treatment of Uterine Fibroids.

Surg Technol Int 2020 05;36:179-185

Department of Obstetrics and Gynecology, University of Louisville, School of Medicine, Louisville, Kentucky.

Introduction: Fibroids are highly prevalent among reproductive-aged women and have a significant impact on their wellbeing. Myomectomy is a fertility-sparing option for these patients.

Materials And Methods: This paper is a comprehensive, evidence-based and updated review of literature regarding myomectomy techniques. Read More

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Mesonephric adenocarcinoma of the uterine cervix with rare lung metastases: A case report and review of the literature.

World J Clin Cases 2020 May;8(9):1735-1744

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China.

Background: Mesonephric adenocarcinoma (MNA) of the female reproductive system is a rare tumor arising from remnants of the mesonephric duct, which is mainly located in the cervix. MNA often occurs in adult women. Due to the rarity of the disease and few reports, the specific clinical features have not been established. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i9.1735DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211527PMC

Molecular Profiling of Benign Metastasizing Leiomyoma of the Uterus Revealing Unique Novel Therapeutic Targets.

Cureus 2020 Apr 16;12(4):e7701. Epub 2020 Apr 16.

Genitourinary Oncology, Creighton University School of Medicine/University of Arizona Cancer Center at Dignity Health St. Joseph's, Phoenix, USA.

Extra-uterine manifestations of benign uterine leiomyoma (fibroids) are rare. Benign metastasizing leiomyoma (BML) comprises an uncommon variant characterized by metastatic lung nodules. The pathologic characteristics for BML are well known in the literature; however, the underlying biology and molecular mechanisms remain poorly understood. Read More

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http://dx.doi.org/10.7759/cureus.7701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7233500PMC

Robotic uterine transposition for a cervical cancer patient with pelvic micrometastases after conization and pelvic lymphadenectomy.

Int J Gynecol Cancer 2020 Jun 18;30(6):898-899. Epub 2020 May 18.

Department of Surgical Oncology, Erasto Gaertner Hospital, Curitiba, Paraná, Brazil

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http://dx.doi.org/10.1136/ijgc-2020-001250DOI Listing

Apolipoprotein(a), an enigmatic anti-angiogenic glycoprotein in human plasma: A curse or cure?

Pharmacol Res 2020 May 11;158:104858. Epub 2020 May 11.

Diabetes Biology Lab, Division of Cardiovascular Diseases and Diabetes Biology, Rajiv Gandhi Centre for Biotechnology, Poojappura, Thycaud P.O, Thiruvananthapuram, 695514, Kerala, India. Electronic address:

Angiogenesis is a finely co-ordinated, multi-step developmental process of the new vascular structure. Even though angiogenesis is regularly occurring in physiological events such as embryogenesis, in adults, it is restricted to specific tissue sites where rapid cell-turnover and membrane synthesis occurs. Both excessive and insufficient angiogenesis lead to vascular disorders such as cancer, ocular diseases, diabetic retinopathy, atherosclerosis, intra-uterine growth restriction, ischemic heart disease, stroke etc. Read More

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http://dx.doi.org/10.1016/j.phrs.2020.104858DOI Listing

Multiple HPV 16 infection with two strains: a possible marker of neoplastic progression.

BMC Cancer 2020 May 19;20(1):444. Epub 2020 May 19.

Department of General Surgery and Medical Surgery Specialties, Gynecological Clinic, University of Catania, Catania, Italy.

Background: We studied the cases of single and multiple HPV infection and analyzed the correlation with negative cases, and preneoplastic and neoplastic lesions of the uterine cervix with the aim of making a contribution to the prognostic factor under discussion.

Methods: Nine hundred nine women undergoing second level screening because they had been positive at cervical cytology were enrolled. All the patients underwent colposcopy and cervical biopsy with viral genotyping. Read More

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http://dx.doi.org/10.1186/s12885-020-06946-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236333PMC

Identification of Multiple High-Risk Human Papillomavirus Infections in a Rural Population of Canatlan, Durango, Mexico.

Genet Test Mol Biomarkers 2020 May 20. Epub 2020 May 20.

Laboratorio de Biomedicina Molecular, Facultad de Ciencias Químicas, Universidad Juárez del Estado de Durango, Durango, Durango, México.

The human papillomavirus (HPV) is the most frequent etiological agent driving development of cervical cancer (CC); therefore typing and classifying the status of these infections are of great importance for treatment. The frequency of the various HPV types may change in relation to low-grade lesions and have the potential to cause more severe lesions. The purpose of this study was the identification and typing of HPV in a rural population in Mexico. Read More

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http://dx.doi.org/10.1089/gtmb.2019.0189DOI Listing

Identification of Differentially Expressed Gene Transcripts in Porcine Endometrium during Early Stages of Pregnancy.

Life (Basel) 2020 May 16;10(5). Epub 2020 May 16.

Institute of Veterinary Medicine, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, 87-100 Toruń, Poland.

During the early stages of pregnancy, the uterine endometrium undergoes dramatic morphologic and functional changes accompanied with dynamic variation in gene expression. Pregnancy-stage specific differentially expressed gene (DEG)-transcript-probes were investigated and identified by comparing endometrium transcriptome at 9th day (9D), 12th day (12D) and 16th day (16D) of early pregnancy in Polish large-white (PLW) gilts. Endometrium comparisons between 9D-vs-12D, 9D-vs-16D and 12D-vs-16D of early pregnancy identified 6049, 374 and 6034 highly significant DEG-transcript-probes ( < 0. Read More

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http://dx.doi.org/10.3390/life10050068DOI Listing

Proposal of a Two-Tier System in Grouping Adenocarcinoma of the Uterine Cervix.

Cancers (Basel) 2020 May 15;12(5). Epub 2020 May 15.

Department of Obstetrics and Gynecology, Tokai University School of Medicine, Kanagawa 259-1193, Japan.

(1) : This study examined the use of a two-tier system in grouping cervical adenocarcinoma for survival discrimination. (2) : A nationwide retrospective observational cohort study was conducted using the Japan Society of Gynecologic Oncology tumor registry database from 2001 to 2015 ( = 86,754). Adenocarcinoma subtypes were grouped as type 1 (endocervical usual type and endometrioid) or type 2 (serous, clear, mucinous, and not otherwise specified), based on their relative survival compared with that of squamous tumors. Read More

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http://dx.doi.org/10.3390/cancers12051251DOI Listing

Crosslinked Hyaluronic Acid Gels for the Prevention of Intrauterine Adhesions after a Hysteroscopic Myomectomy in Women with Submucosal Myomas: A Prospective, Randomized, Controlled Trial.

Life (Basel) 2020 May 15;10(5). Epub 2020 May 15.

Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei 112, Taiwan.

Intrauterine adhesion (IUA), fibrosis, and scarring resulting from damage to the endometrium is a rare but serious clinical disease, contributing to a significant impairment of reproductive function. Uterine instrumentation, especially that of a hysteroscopic myomectomy, has become the main cause of IUA. Therefore, a prospective randomized controlled study to assess the effectiveness and short-term safety of the use of hyaluronic acid gels in the prevention of IUA after a hysteroscopic myomectomy and an evaluation of the characteristics of IUA observed at follow-up are presented here. Read More

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http://dx.doi.org/10.3390/life10050067DOI Listing

Prognostic factors in women with cervical cancer stage IIIC1r treated with concurrent chemoradiotherapy.

J Obstet Gynaecol Res 2020 May 19. Epub 2020 May 19.

Department of Obstetrics and Gynecology, Catholic University of Daegu, School of Medicine, Daegu, Republic of Korea.

Aim: The purpose of this study was to evaluate the prognostic factors of patients with stage IIIC1r cervical cancer who underwent concurrent chemoradiotherapy.

Methods: A total of 134 patients treated with chemoradiotherapy for cervical cancer with pelvic and/or paraaortic lymph node metastasis (PALNM) were enrolled in this study. Clinical variables were investigated through review of the patients' medical records. Read More

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http://dx.doi.org/10.1111/jog.14305DOI Listing

The influence of phytoestrogens or estrogens on the proliferation of the rat endocervical mucosa.

Rev Assoc Med Bras (1992) 2020 May;66(2):174-179

. Departamento de Morfologia e Genética - Escola Paulista de Medicina/Universidade Federal de São Paulo - EPM/Unifesp - São Paulo, SP, Brasil.

Objective: Although estrogen therapy is widely used against post-menopausal symptoms, it can present adverse effects, including endometrial cancer. Soy isoflavones are considered a possible alternative to estrogen therapy. However, there are still concerns whether isoflavones exert trophic effects on the uterine cervix. Read More

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http://dx.doi.org/10.1590/1806-9282.66.2.174DOI Listing