146,836 results match your criteria Uterine Cancer


Re-evaluating tumors of purported specialized prostatic stromal origin reveals molecular heterogeneity, including non-recurring gene fusions characteristic of uterine and soft tissue sarcoma subtypes.

Mod Pathol 2021 May 13. Epub 2021 May 13.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Tumors of purported specialized prostatic stromal origin comprise prostatic stromal sarcomas (PSS) and stromal tumors of uncertain malignant potential (STUMP). Prior studies have described their clinicopathologic characteristics, but the molecular features remain incompletely understood. Moreover, these neoplasms are morphologically heterogeneous and the lack of specific adjunctive markers of prostatic stromal lineage make precise definition more difficult, leading some to question whether they represent a specific tumor type. Read More

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Development of endometrial cancer after long-term usage of the levonorgestrel-releasing intrauterine system.

BMJ Case Rep 2021 May 13;14(5). Epub 2021 May 13.

Pathology, Queen Elizabeth Hospital, London, London, UK.

A 52-year-old long-term user of the levonorgestrel-releasing intrauterine system (LNG-IUS) presented with vaginal bleeding. Endometrial biopsy was performed and revealed endometrioid adenocarcinoma. The patient had a laparoscopic hysterectomy and bilateral salpingo-oophorectomy. Read More

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A prospective cohort study of ambient air pollution exposure and risk of uterine leiomyomata.

Hum Reprod 2021 May 13. Epub 2021 May 13.

Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.

Study Question: To what extent are ambient concentrations of particulate matter <2.5 microns (PM2.5), nitrogen dioxide (NO2) and ozone (O3) associated with risk of self-reported physician-diagnosed uterine leiomyomata (UL)?

Summary Answer: In this large prospective cohort study of Black women, ambient concentrations of O3, but not PM2. Read More

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The value of adding a single co-test in HPV primary screening.

Prev Med 2021 May 10:106617. Epub 2021 May 10.

Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

The screening program for cervical cancer in Sweden, recommends screening with HPV test primarily for women over 30 years, but at the first screening test that is performed after the age of 40, both HPV test and cytology is recommended, so-called co-testing. The aim of this study was to examine how many cases of HPV negative cervical dysplasia that were found in this age-group, to be able to estimate the value of adding a co-test in an HPV screening program. A retrospective study of all abnormal cytological samples found in the cytology based screening program in the age group 41-45 years during the years 2012-2016 in the Region of Örebro County was performed. Read More

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Advanced uterine papillary serous cancer: Could there be a role for newer targeted therapeutic approaches or immune checkpoint inhibitors?

J Oncol Pharm Pract 2021 May 13:10781552211015769. Epub 2021 May 13.

Eisenhower Lucy Curci Cancer Center, Rancho Mirage, CA USA.

Background: Although now available in oncology clinics, comprehensive germline mutation testing is being performed only in a minority of patients with advanced uterine papillary serous cancer (UPSC). Some of these patients might harbor various targetable mutations, either heritable or acquired.Data sources: We conducted a retrospective cohort study involving all consecutive patients with UPSC treated at our institution from 2009-2019. Read More

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Mimics of malignancy caused by concurrent imperforate hymen and transverse vaginal septum: an instructive case and review of the literature.

J Int Med Res 2021 May;49(5):3000605211014797

Department of Paediatrics, Tri-Service General Hospital, National Defense Medical Centre, Taipei.

The coexistence of imperforate hymen and vaginal septum is rare and their ability to mimic malignant manifestations have not been frequently reported. This current case report describes a 13-year-old girl that presented with cyclic abdominal pain for 6 months. She was found to have a huge mass via abdominal plain film X-ray and sonography, with inexplicably high levels of serum carcinoembryonic antigen, cancer antigen (CA)-19-9 and CA-125. Read More

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Right extraperitoneal approach for laparoscopic paracaval bulky lymph node dissection for endometrial cancer.

Int J Gynecol Cancer 2021 May 12. Epub 2021 May 12.

Gynecologic Oncology, N.N. Blokhin National Medical Research Center of Oncology оf the Ministry of Health of the Russian Federation, Moscow, Russian Federation.

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Comparison and impact of COVID-19 for patients with cancer: a survival analysis of fatality rate controlling for age, sex and cancer type.

BMJ Health Care Inform 2021 May;28(1)

Department of Biomedical Informatics, The University of Utah School of Medicine, Salt Lake City, Utah, USA

Objectives: Prior research has reported an increased risk of fatality for patients with cancer, but most studies investigated the risk by comparing cancer to non-cancer patients among COVID-19 infections, where cancer might have contributed to the increased risk. This study is to understand COVID-19's imposed HR of fatality while controlling for covariates, such as age, sex, metastasis status and cancer type.

Methods: We conducted survival analyses of 4606 cancer patients with COVID-19 test results from 16 March to 11 October 2020 in UK Biobank and estimated the overall HR of fatality with and without COVID-19 infection. Read More

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Autophagy inhibitor potentiates the antitumor efficacy of apatinib in uterine sarcoma by stimulating PI3K/Akt/mTOR pathway.

Cancer Chemother Pharmacol 2021 May 12. Epub 2021 May 12.

Department of Gynecology, Fourth Hospital of Hebei Medical University, No.12, Jiankang Road, Shijiazhuang, 050011, Hebei, China.

Aim: The present study aims to examine the effects of apatinib combined with autophagy inhibitor 3-Methyladenine (3-MA) on the proliferation and apoptosis of human uterine sarcoma in FU-MMT-1 and MES-SA cells and its tumor inhibition effect in xenograft model of uterine sarcoma.

Methods: Different concentrations of 3-MA and apatinib were used to treat the uterine sarcoma cell lines (MES-SA and FU-MMT-1 cells). The cell viability was detected by CCK8 method. Read More

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Prevalence of late-stage presentation and associated factors of cervical cancer patients in Tikur Anbesa Specialized Hospital, Ethiopia: institutional based cross-sectional study.

Infect Agent Cancer 2021 May 11;16(1):30. Epub 2021 May 11.

Department of Pediatrics and Child Health Nursing, School of Nursing, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Background: Cancer of the uterine cervix remains a main public health problem in Sub-Saharan Africa. About two-thirds of patients with cervical cancer were diagnosed at late stage with contributing factors of out-of-pocket medical bill, looking for care out of conventional health settings and multiple visits to healthcare facilities before diagnostic confirmations in Addis Ababa. Therefore, the aim of this study was to identify prevalence of late-stage presentation and associated factors among cervical cancer patients in Tikur Anbesa Specialized Hospital (TASH). Read More

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The effectiveness of cold-knife conization (CKC) for post-menopausal women with cervical high-grade squamous intraepithelial lesion: a retrospective study.

BMC Surg 2021 May 12;21(1):241. Epub 2021 May 12.

Department of Gynecological Oncology, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin Key Laboratory of Human Development and Reproductive Regulation, 156 Nankai Third Road, Nankai, Tianjin, 300100, People's Republic of China.

Background: The effectiveness of surgery of high-grade squamous intraepithelial lesion in post-menopausal women needs to be investigated. This study evaluated the clinical significance of cold-knife conization in the diagnosis and surgery of cervical high-grade squamous intraepithelial lesions in post-menopausal women.

Methods: We conducted a retrospective analysis of post- and pre-menopausal patients with high-grade squamous intraepithelial lesion. Read More

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Fractions of Ageratum conyzoides L. (Compositae) induce mitochondrial-mediated apoptosis in rats: Possible option in monosodium glutamate-induced hepatic and uterine pathological disorder.

J Ethnopharmacol 2021 May 8:114192. Epub 2021 May 8.

Laboratories for Biomembrane Research and Biotechnology, Department of Biochemistry, College of Medicine, University of Ibadan, Nigeria. Electronic address:

Ethnopharmacological Relevance: Several pathological disorders have been attributed to either oxidative stress or defect in apoptotic signaling pathway. Some bioactive compounds elicit their antiproliferative properties by induction of apoptosis via mitochondrial permeability transition (mPT) pore opening.

Aim Of Study: The present study therefore investigated the effects of various fractions of methanol extract of Ageratum conyzoides L. Read More

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The new-generation proteasome inhibitor oprozomib increases the sensitivity of cervical cancer cells to cisplatin-induced apoptosis.

J Biol Regul Homeost Agents 2021 Mar-Apr;35(2):559-569

Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.

This study aimed to evaluate the anti-tumor effect of a new generation of protease inhibitor, oprozomib (OPZ), used alone and in combination with cisplatin, also called CDDP, on cervical cancer. Five different types of cervical cancer cell lines - HeLa, Caski, HeLa-CDDP, C33a, and SiHa - and one nontransformed cervical cell line - HaCaT -were treated with OPZ alone or in combination with cisplatin. The inhibitory effects of OPZ and cisplatin on the proliferation of cervical cancer cells were then analyzed using cytotoxicity tests, flow cytometry, and Western blotting. Read More

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A Rare Case of Early Transformation of Gestational Trophoblastic Neoplasia Following Molar Pregnancy.

Am J Case Rep 2021 May 11;22:e930789. Epub 2021 May 11.

Department of Obstetrics and Gynecology, Faculty of Medicine, Padjadjaran University - Dr. Hasan Sadikin Hospital, Bandung, Indonesia.

BACKGROUND Gestational trophoblastic disease (GTD) encompasses a group of disorders that arise from abnormal growth of trophoblastic tissue. The spectrum of GTD includes 2 major groups: benign and malignant. The benign form is a hydatidiform mole, either complete or partial; the malignant forms, referred to as gestational trophoblastic neoplasia (GTN), consist of invasive moles, choriocarcinomas, placental site trophoblastic tumors, and epithelioid trophoblastic tumors. Read More

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Pan-cancer landscape of (PD-L1) copy number changes in 244 584 patient samples and the correlation with PD-L1 protein expression.

J Immunother Cancer 2021 May;9(5)

Foundation Medicine Inc, Cambridge, Massachusetts, USA.

Introduction: Several studies have shown clinical outcomes data that support the use of ) copy-number (CN) gains and/or losses as a biomarker for immune checkpoint inhibitor (ICPI). Here, we present the landscape of CN changes across a large cohort of solid tumor cases and correlate these with PD-L1 protein expression by immunohistochemistry.

Methods: We analyzed all cases that underwent comprehensive genomic profiling (CGP) testing at Foundation Medicine between August 2014 and June 2020. Read More

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Establishment and preclinical application of a patient-derived xenograft model for uterine cancer.

Gynecol Oncol 2021 May 7. Epub 2021 May 7.

Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. Electronic address:

Background: The patient-derived xenograft (PDX) model is a promising translational platform for duplicating the characteristics of primary tumors. Here, we established and characterized PDX models of uterine cancer to demonstrate their utility for preclinical drug testing.

Materials And Methods: We generated PDX tumors surgically derived from 58 cases of uterine cancer. Read More

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Potential prognostic factors in progression-free survival for patients with cervical cancer.

BMC Cancer 2021 May 10;21(1):531. Epub 2021 May 10.

Zhuhai Hospital of Traditional Chinese and Western Medicine, Zhuhai City, Guangdong, People's Republic of China.

Background: Cervical cancer continues to be one of the leading causes of cancer deaths among females in low and middle-income countries. In this study, we aimed to assess the independent prognostic value of clinical and potential prognostic factors in progression-free survival (PFS) in cervical cancer.

Methods: We conducted a retrospective study on 92 cervical cancer patients treated from 2017 to 2019 at the Zhuhai Hospital of Traditional Chinese and Western Medicine. Read More

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Measuring rater bias in diagnostic tests with ordinal ratings.

Stat Med 2021 May 9. Epub 2021 May 9.

Department of Biostatistics, Boston University, Boston, Massachusetts, USA.

Diagnostic tests are frequently reliant upon the interpretation of images by skilled raters. In many clinical settings, however, the variability observed between experts' ratings plays a detrimental role in the degree of confidence in these interpretations, leading to uncertainty in the diagnostic process. For example, in breast cancer testing, radiologists interpret mammographic images, while breast biopsy results are examined by pathologists. Read More

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Emergency department visits among people with cancer: Frequency, symptoms, and characteristics.

J Am Coll Emerg Physicians Open 2021 Jun 1;2(3):e12438. Epub 2021 May 1.

Division of Cancer Prevention and Control National Center for Chronic Disease Prevention and Health Promotion Centers for Disease Control and Prevention Atlanta Georgia USA.

Objective: People with cancer are increasingly more likely to visit an emergency department for acute care than the general population. They often have long wait times and more exposure to infection and receive treatment from staff less experienced with cancer-related problems. Our objective was to examine emergency department (ED) visits among people with cancer to understand how often and why they seek care. Read More

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A Pancancer Analysis of the Expression Landscape and Clinical Relevance of Fibroblast Growth Factor Receptor 2 in Human Cancers.

Front Oncol 2021 21;11:644854. Epub 2021 Apr 21.

Department of Pathology, Xiangya Hospital, Central South University, Changsha, China.

Fibroblast growth factor receptor 2 (FGFR2) is frequently altered in tumors and one of the top therapeutic targets in cholangiocarcinoma (CHOL) with fusions. Although there have been several studies on individual tumors, a comprehensive analysis of genetic aberrations and their simultaneous clinical implications across different tumors have not been reported. In this study, we used the large comprehensive datasets available, covering over 10,000 tumor samples across more than 30 cancer types, to analyze abnormal expression, methylation, alteration (mutations/fusions and amplification/deletion), and their clinical associations. Read More

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The impact of Aurora kinase A genetic polymorphisms on cervical cancer progression and clinicopathologic characteristics.

Int J Med Sci 2021 22;18(11):2457-2465. Epub 2021 Apr 22.

Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.

The aims of this study were to explore the involvement of Aurora kinase A (AURKA) gene single nucleotide polymorphisms (SNPs) in uterine cervical cancer that has not yet been investigated. One hundred and six patients with cervical invasive cancer and 94 patients with precancerous lesions, and 302 Taiwanese female individuals were included. AURKA SNPs rs2273535, rs6024836, rs2064863 and rs1047972 were analyzed for genotypic distributions using real-time polymerase chain reaction. Read More

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Impact of genetic variants on uterine cervical cancer clinicopathologic characteristics.

Int J Med Sci 2021 7;18(11):2339-2346. Epub 2021 Apr 7.

Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.

The aims of this study were to investigate the relationships among () genetic variants and development and clinicopathological characteristics of uterine cervical cancer, and patient survival in Taiwanese women. The study enrolled 125 patients with invasive cancer and 98 patients with precancerous lesions of uterine cervix, and 325 control women. genetic variants rs2120243, rs3816527, rs2305619 and rs1840680 were selected and their genotypic distributions were determined by real-time polymerase chain reaction. Read More

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[Research Progress of the Effects of Vitamin D Supplementation on Glycemic Control and Adverse Maternal-neonatal Outcomes in Gestational Diabetes Mellitus Patients].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2021 Apr;43(2):253-258

School of Public Health,Hangzhou Normal University Division of Health Sciences,Hangzhou 311121,China.

Gestational diabetes mellitus(GDM)can cause blood glucose disorders in pregnant women and result in adverse maternal-neonatal outcomes.Vitamin D(VD)can improve glucose tolerance and insulin sensitivity,and thus theoretically,VD supplementation during pregnancy could improve glycemic control as well as maternal-neonatal outcomes in GDM patients.Although studies have shown that VD deficiency is associated with poor maternal-neonatal outcomes in GDM patients,no solid conclusion has been drawn with regard to the effects of VD supplementation on these patients. Read More

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The predictive value of postoperative C-reactive protein (CRP), procalcitonin (PCT) and triggering receptor expressed on myeloid cells 1 (TREM-1) for the early detection of pulmonary infection following laparoscopic general anesthesia for cervical cancer treatment.

Ann Palliat Med 2021 Apr;10(4):4502-4508

Department of Anesthesiology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Chinese Academy of Sciences, Sichuan Translational Medicine Research Hospital, Chengdu, China.

Background: To analyze the predictive value of postoperative C-reactive protein (CRP), procalcitonin (PCT), and triggering receptor expressed on myeloid cells 1 (TREM-1) for the early detection of pulmonary infection following laparoscopic general anesthesia for cervical cancer treatment.

Methods: We enrolled 80 patients who underwent radical surgery for cervical cancer in our hospital from March 2018 to March 2020 and divided them into an infected group (n=34) and non-infected group (n=46) according to whether they were complicated by lung infection after surgery. The levels of CRP, PCT, and TREM-1 were compared between the two groups, and logistic regression was used to analyze the risk factors for pulmonary infection. Read More

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