151,921 results match your criteria Uses of the Postoperatively Adjustable Implant in Aesthetic Breast Surgery


Advances in Anti-GD2 Immunotherapy for Treatment of High-risk Neuroblastoma.

J Pediatr Hematol Oncol 2019 Apr;41(3):163-169

Department of Pediatrics, Division of Hematology, Oncology and Bone Marrow Transplant.

Neuroblastoma (NBL) is the most common extracranial solid tumor in pediatrics, yet overall survival is poor for high-risk cases. Immunotherapy regimens using a tumor-selective antidisialoganglioside (anti-GD2) monoclonal antibody (mAb) have been studied for several decades now, but have only recently been incorporated into standard of care treatment for patients with high-risk NBL with clear benefit. Here we review a brief history of anti-GD2-based immunotherapy, current areas of neuroblastoma research targeting GD2, and potential diagnostic and therapeutic uses targeting GD2. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001369DOI Listing

Power Point Therapy: An Effective and Simple Treatment for Subacute Back Pain - A Randomized Controlled Trial.

Complement Med Res 2019 Mar 20:1-13. Epub 2019 Mar 20.

Department of Pediatric Gastroenterology, Medical University Poznan, Poznan, Poland.

Objective: Subacute low back pain is a frequent problem with the danger of chronification. Conventional treatment options are not always effective. Power Point therapy (PPT) is a novel approach that uses reflexological insights and can be easily applied by practitioners and patients. Read More

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http://dx.doi.org/10.1159/000494458DOI Listing

Detection of brain stimuli using Ramanujan periodicity transforms.

J Neural Eng 2019 Mar 21. Epub 2019 Mar 21.

Electrical and Computer Engineering, University of Central Florida College of Engineering and Computer Science, Orlando, Florida, UNITED STATES.

Objective: The ability to efficiently match the frequency of the brain's response to repetitive visual stimuli in real time is the basis for reliable SSVEP-based Brain-Computer-Interfacing (BCI).

Approach: The detection of different stimuli is posed as a composite hypothesis test, where SSVEPs are assumed to admit a sparse representation in a Ramanujan Periodicity Transform (RPT) dictionary. For the binary case, we develop and analyze the performance of an RPT detector based on a derived generalized likelihood ratio test. Read More

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http://dx.doi.org/10.1088/1741-2552/ab123aDOI Listing

Learning joint space-time-frequency features for EEG decoding on small labeled data.

Neural Netw 2019 Mar 11;114:67-77. Epub 2019 Mar 11.

State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China; Institutes for Robotics and Intelligent Manufacturing, Chinese Academy of Sciences, Shenyang 110016, China. Electronic address:

Brain-computer interfaces (BCIs), which control external equipment using cerebral activity, have received considerable attention recently. Translating brain activities measured by electroencephalography (EEG) into correct control commands is a critical problem in this field. Most existing EEG decoding methods separate feature extraction from classification and thus are not robust across different BCI users. Read More

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http://dx.doi.org/10.1016/j.neunet.2019.02.009DOI Listing

Water quality modelling under unsteady state analysis: Strategies for planning and management.

J Environ Manage 2019 Mar 18;239:150-158. Epub 2019 Mar 18.

Department of Civil and Environmental Engineering, Colorado State University, Fort Collins, United States.

Recent water resources planning and management strategies state that the concepts of risk and variable inputs should be appraised in order to comply with multiple conditions. This becomes evident especially in environments with diverse uses of water, land use and climate change. In such a context, modelling of discharges and concentrations in rivers are valuable strategies to predict different scenarios. Read More

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http://dx.doi.org/10.1016/j.jenvman.2019.03.047DOI Listing

Outdoor thermal performance of heterogeneous urban environment: An indicator-based approach for climate-sensitive planning.

Sci Total Environ 2019 Mar 12;669:872-886. Epub 2019 Mar 12.

Department of Computer Science and Engineering (CSE), Indian Institute of Technology Bombay, Mumbai 400076, India.

The thermal profile of the urban built-up area is essential for reducing the impact of built-up areas on urban heat stress. This study quantifies the variations in the outdoor thermal profile of built forms in a heterogeneous urban area. A two-step process was adopted to quantify built form induced heat stress. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.152DOI Listing

Household fuel use and latent tuberculosis infection in a Nepali population.

Environ Res 2019 Mar 14;173:69-76. Epub 2019 Mar 14.

Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720, USA. Electronic address:

Background: The risk of developing latent tuberculosis infection (LTBI) associated with cooking with solid fuels is unknown. This study examined the relationship between household fuel uses and LTBI in adults living in Nepal, a country with a high incidence of tuberculosis.

Methods: Participants were 1088 adults aged 18-70 years, members of the control group of a population-based case-control study of pulmonary TB (PTB) in people without previous TB, living in Kaski and neighboring districts of Nepal. Read More

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http://dx.doi.org/10.1016/j.envres.2019.03.024DOI Listing

Lanthanum-Catalyzed Enantioselective Trifluoromethylation using Electrophilic Hypervalent Iodine Reagent.

Chemistry 2019 Mar 21. Epub 2019 Mar 21.

Universitat Autonoma de Barcelona, Department of Chemistry, Faculty of Sciences, Organic Chemistry Section, Cerdanyola del Vallès, 08193, Barcelona, SPAIN.

A highly enantioselective catalytic method for the synthesis of quaternary α-trifluoromethyl derivatives of 3-oxo esters is described. The reaction uses lanthanum (III) triflate and chiral pybox-type C2-symmetric ligands to generate intermediate La(III) complexes that incorporate an enolate moiety of the starting 3-oxo ester and the trifluoromethyl transfer reagent. The enantioselectivity of the reaction stems from the efficient blockage of one of the prochiral faces of the La(III) enolate by one unit of the C2-symmetric ligand. Read More

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http://dx.doi.org/10.1002/chem.201900598DOI Listing

Novel GC-MS/MS technique reveals a complex steroid fingerprint of subclinical hypercortisolism in adrenal incidentalomas.

J Clin Endocrinol Metab 2019 Mar 21. Epub 2019 Mar 21.

Steroid Hormone Unit, Institute of Endocrinology, Prague 1, Czech Republic.

Context: Improvement of imaging methods has led to more incidental adrenal tumor findings, especially adenomas. Routine hormonal evaluation uses only a few steroids to evaluate possible hormonal hypersecretion of these adenomas, but a wide spectrum of serum steroid hormone changes has not been published.

Objective: To measure the serum levels of 83 steroids from patients with unilateral and bilateral adrenal incidentalomas to uncover full steroid profile changes in patients with subclinical hypercortisolism (SH). Read More

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http://dx.doi.org/10.1210/jc.2018-01926DOI Listing

Photostable and highly emissive glassy organic dots exhibiting thermally activated delayed fluorescence.

Chem Commun (Camb) 2019 Mar 21. Epub 2019 Mar 21.

Center for Organic Photonics and Electronics Research (OPERA), Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan. and JST, ERATO, Adachi Molecular Exciton Engineering Project, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan and Department of Chemistry and Biochemistry, Kyushu University, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan and International Institute for Carbon Neutral Energy Research (WPI-I2CNER), Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan.

Organic nanoparticles (O-dots) with a high photoluminescence quantum yield (94%) and long-lived delayed emission (3.1 μs) originating from thermally activated delayed fluorescence (TADF) were developed as glassy state particles using an oil in water emulsion under high pressure (<20 bar). The TADF glassy O-dots exhibit not only good dispersibility and high photostability in water but also good uptake properties into living cells. Read More

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http://dx.doi.org/10.1039/c9cc01420aDOI Listing

When technology cares for people with dementia: A critical review using neuropsychological rehabilitation as a conceptual framework.

Neuropsychol Rehabil 2019 Mar 21:1-40. Epub 2019 Mar 21.

c Laboratorio de Neurociencia Cognitiva y Social, LANCyS, Facultad de Psicología , Universidad Diego Portales , Santiago , Chile.

Clinicians and researchers have become increasingly interested in the potential of technology in assisting persons with dementia (PwD). However, several issues have emerged in relation to how studies have conceptualized who the main technology user is (PwD/carer), how technology is used (as compensatory, environment modification, monitoring or retraining tool), why it is used (i.e. Read More

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http://dx.doi.org/10.1080/09602011.2019.1589532DOI Listing

"Too much too soon, let me out of here!" Psychiatric and obstetric implications of a child's pregnancy.

Australas Psychiatry 2019 Mar 21:1039856219838344. Epub 2019 Mar 21.

Senior Staff Specialist, Obstetrics and Gynecology, Redcliffe Hospital, Caboolture, QLD, and; Conjoint Site Coordinator, Northside Clinical School, Faculty of Medicine, University of Queensland, Redcliffe, QLD, Australia.

Objective:: Psychiatrists may become involved in circumstances where a child is seeking termination of pregnancy. Potential roles include capacity advice and advocacy, but ethical and legal uncertainties abound. This paper uses illustrative cases, in an Australian jurisdiction, to exemplify the issues. Read More

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http://dx.doi.org/10.1177/1039856219838344DOI Listing

[The future of psychiatrists: subquota and quota-raising in Belgium].

Authors:
E Van Assche

Tijdschr Psychiatr 2019 ;61(3):205-207

Background: In Belgium, the number of medical students that can start a psychiatry residency is defined by a fixed number.
AIM: To present this calculation process.
METHOD: To reconstruct this process based on documents published by the planning committee, a federal committee comprised of a representation from different universities, several ministries, and Belgian communities. Read More

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January 2019

Human Biospecimens Come from People.

Ethics Hum Res 2019 Mar;41(2):22-28

Professor at the Center for Bioethics and Social Sciences in Medicine at the University of Michigan.

Contrary to the revised Common Rule, and contrary to the views of many bioethicists and researchers, we argue that broad consent should be sought for anticipated later research uses of deidentified biospecimens and health information collected during medical care. Individuals differ in the kinds of risk they find concerning and in their willingness to permit use of their biospecimens for future research. For this reason, asking their permission for unspecified research uses is a fundamental expression of respect for them as persons and should be done absent some compelling moral consideration to the contrary. Read More

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http://dx.doi.org/10.1002/eahr.500009DOI Listing

Syntrophus aciditrophicus uses the same enzymes in a reversible manner to degrade and synthesize aromatic and alicyclic acids.

Environ Microbiol 2019 Mar 20. Epub 2019 Mar 20.

Department of Microbiology and Plant Biology, University of Oklahoma, Norman, OK, 73019.

Syntrophy is essential for the efficient conversion of organic carbon to methane in natural and constructed environments, but little is known about the enzymes involved in syntrophic carbon and electron flow. Syntrophus aciditrophicus strain SB syntrophically degrades benzoate and cyclohexane-1-carboxylate and catalyzes the novel synthesis of benzoate and cyclohexane-1-carboxylate from crotonate. We used proteomic, biochemical, and metabolomic approaches to determine what enzymes are used for fatty, aromatic, and alicyclic acid degradation versus for benzoate and cyclohexane-1-carboxylate synthesis. Read More

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http://dx.doi.org/10.1111/1462-2920.14601DOI Listing

FLAS: fast and high throughput algorithm for PacBio long read self-correction.

Bioinformatics 2019 Mar 21. Epub 2019 Mar 21.

School of Computer Science and Technology, Beijing Institute of Technology, Beijing, China.

Motivation: The third generation PacBio long reads have greatly facilitated sequencing projects with very large read lengths, but they contain about 15% sequencing errors and need error correction. For the projects with long reads only, it is challenging to make correction with fast speed, and also challenging to correct a sufficient amount of read bases, i.e. Read More

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http://dx.doi.org/10.1093/bioinformatics/btz206DOI Listing

Changing seasonal variation in births by sociodemographic factors: a population-based register study.

Hum Reprod Open 2018 29;2018(4):hoy015. Epub 2018 Sep 29.

Department of Sociology, The Stockholm University Demography Unit, Stockholm University, SE-106 91 Stockholm, Sweden.

Study Question: Have seasonal variations in births by factors related to maternal education, age, parity and re-partnering changed over a 72-year period?

Summary Answer: Seasonal variation in births has been reduced overall but also changed its pattern over the last seven decades.

What Is Known Already: The number of births varies markedly by season, but the causes of this variation are not fully understood. Seasonality of births is, in some populations, strongly influenced by sociodemographic factors. Read More

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http://dx.doi.org/10.1093/hropen/hoy015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276686PMC
September 2018

The Importance of Antimicrobial Resistance Monitoring Worldwide and the Origins of SENTRY Antimicrobial Surveillance Program.

Open Forum Infect Dis 2019 Mar 15;6(Suppl 1):S1-S4. Epub 2019 Mar 15.

JMI Laboratories, North Liberty, Iowa.

The origins of how and why the SENTRY Antimicrobial Surveillance Program was created are briefly described, with additional details on how the isolates are collected and tested as well as the important uses of the data in monitoring antimicrobial resistance and drug development. Read More

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http://dx.doi.org/10.1093/ofid/ofy346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419910PMC

ClinGen expert clinical validity curation of 164 hearing loss gene-disease pairs.

Genet Med 2019 Mar 21. Epub 2019 Mar 21.

Laboratory for Molecular Medicine, Partners Healthcare Personalized Medicine, Cambridge, MA, USA.

Purpose: Proper interpretation of genomic variants is critical to successful medical decision making based on genetic testing results. A fundamental prerequisite to accurate variant interpretation is the clear understanding of the clinical validity of gene-disease relationships. The Clinical Genome Resource (ClinGen) has developed a semiquantitative framework to assign clinical validity to gene-disease relationships. Read More

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http://dx.doi.org/10.1038/s41436-019-0487-0DOI Listing

A Wide-Area Coverage 35 Gb/s Visible Light Communications Link for Indoor Wireless Applications.

Sci Rep 2019 Mar 20;9(1):4952. Epub 2019 Mar 20.

Department of Engineering Science, University of Oxford, Oxford, OX1 3PJ, United Kingdom.

Visible Light Communications (VLC) can provide both illumination and communications and offers a means to alleviate the predicted spectrum crunch for radio-frequency wireless communications. In this paper, we report a laser diode based white-light communications link that operates over a wide area and supports high data rates. The proposed system is a four-colour multiplexed high-speed VLC system that uses a microelectromechanical system (MEMS) mirror-based beam-steering. Read More

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http://dx.doi.org/10.1038/s41598-019-41397-6DOI Listing

A Novel Murine Model Expressing a Chimeric mSCARB2/hSCARB2 Receptor is Highly Susceptible to Oral Infection with Clinical Isolates of EV71.

J Virol 2019 Mar 20. Epub 2019 Mar 20.

Graduate Institute of Biomedical Science, Chang Gung University, Guishan, Taoyuan, Taiwan

EV71 infection is generally associated with hand-foot-mouth disease (HFMD), and may cause severe neurological disorders and even death. An effective murine oral infection model for studying the pathogenesis of various clinical EV71 isolates is lacking. We developed a transgenic mouse that expresses EV71 receptor, that is human scavenger receptor class B member 2 (hSCARB2), in a pattern highly similar to that of murine endogenous mSCARB2 protein. Read More

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http://dx.doi.org/10.1128/JVI.00183-19DOI Listing

Cross-national comparison of two general population job exposure matrices for physical work exposures.

Occup Environ Med 2019 Mar 20. Epub 2019 Mar 20.

Division of General Medical Sciences, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.

Objectives: Job exposure matrices (JEMs) are increasingly used to estimate physical workplace exposures. We conducted a cross-national comparison of exposure estimates from two general population JEMs to aid the interpretation of exposure-outcome associations across countries and to explore the feasibility of cross-national application of JEMs to provide workplace physical exposure estimates.

Methods: We compared physical exposure estimates from two general population JEMs created from the French study (27 exposure variables) and the American Occupational Information Network database (21 exposure variables). Read More

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http://dx.doi.org/10.1136/oemed-2018-105408DOI Listing

Structural analysis of a plant fatty acid amide hydrolase provides insights into the evolutionary diversity of bioactive acylethanolamides.

J Biol Chem 2019 Mar 20. Epub 2019 Mar 20.

University of North Texas, United States.

-Acylethanolamines (NAEs) are fatty-acid derivatives that in animal systems include the well-known bioactive metabolites of the endocannabinoid signaling pathway. Plants use NAE signaling as well, and these bioactive molecules often have oxygenated acyl moieties. Here, we report the three-dimensional crystal structures of the signal-terminating enzyme fatty acid amide hydrolase (FAAH) from Arabidopsis in its apo and ligand-bound forms at 2. Read More

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http://dx.doi.org/10.1074/jbc.RA118.006672DOI Listing

Nasal fistula, epidermal cyst and hypernatremia in a girl presenting holoprosencephaly due to a rare ZIC2 point mutation.

Eur J Med Genet 2019 Mar 17. Epub 2019 Mar 17.

Clinical Genetics, UFCSPA and Santa Casa de Misericórdia de Porto Alegre (SCMPA), RS, Brazil; Graduate Program in Pathology, UFCSPA, RS, Brazil. Electronic address:

Holoprosencephaly is the most common brain malformation in humans and it is a complex genetic disorder. We report on a patient with holoprosencephaly caused by a rare ZIC2 mutation presenting a bifid nose associated with a nasal fistula and an epidermal cyst, besides hypernatremia. The patient was a 1 year and 4 months old girl that developed an important neuropsychomotor delay. Read More

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http://dx.doi.org/10.1016/j.ejmg.2019.03.005DOI Listing

Surface colonization and subsequent development of infections with multi drug resistant organisms in a neonatal intensive care unit.

Ann Clin Microbiol Antimicrob 2019 Mar 20;18(1):12. Epub 2019 Mar 20.

Department of Microbiology, St. John's Medical College, Sarjapur Road, Bangalore, Karnataka, 560034, India.

Background: This study analyzes colonization of the neonates in a NICU and incidence of these colonized infants developing infections due to the colonizers.

Methods: Over a 12 month period, samples (surface swabs and rectal swabs) were obtained from all the infants admitted to NICU. The samples were cultured and examined for the presence of colonizers and especially for multi-drug resistant organisms. Read More

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http://dx.doi.org/10.1186/s12941-019-0312-2DOI Listing

Lead Molecules for Targeted Urease Inhibition: An Updated Review From 2010 -2018.

Curr Protein Pept Sci 2019 Mar 20. Epub 2019 Mar 20.

Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana. India.

The field of enzyme inhibition is a tremendous and quickly growing territory of research. Urease, a nickel containing metalloenzyme found in bacteria, algae, fungi, and plants, brings hydrolysis of urea and plays important role in the environmental nitrogen cycle. Apart from this it was found to be responsible for many pathological conditions due to its presence in many microorganisms such as H. Read More

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http://dx.doi.org/10.2174/1389203720666190320170215DOI Listing

Why and how the co-occurring familiar object matters in Fast Mapping (FM)? Insights from computational models.

Authors:
Matthew H C Mak

Cogn Neurosci 2019 Mar 21:1-3. Epub 2019 Mar 21.

a Department of Experimental Psychology, Medical Sciences Division , University of Oxford , Oxford , UK.

This article uses insights from computational semantic networks to explain why the co-occurring familiar objects are critical to the Fast Mapping (FM) procedure. I first propose that the co-occurring familiar objects provide the novel targets with a 'mimicry opportunity', which may facilitate the establishment of targets in long-term cortical memory networks. I then argue that the occurrence of rapid cortical learning may depend on how 'well-connected' the co-occurring familiar object is in long-term memory networks. Read More

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http://dx.doi.org/10.1080/17588928.2019.1593121DOI Listing
March 2019
2.375 Impact Factor

Relay Positions Considering Interference from Other Sub-Channels in OFDMA-Based D2D Group-Casting Systems.

Sensors (Basel) 2019 Mar 19;19(6). Epub 2019 Mar 19.

Department of Information and Communication Engineering, Dongguk University, Seoul 04602, Korea,

Device-to-device (D2D) communication is a technique for direct communication between devices without going through a base station or other infrastructure. D2D communication technology has the advantages of improving spectrum efficiency and reducing transmission delay and transmission power. In D2D communication systems, orthogonal frequency-division multiple access (OFDMA) is widely used to maintain similarities with cellular communication systems and to secure transmission distance. Read More

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http://dx.doi.org/10.3390/s19061374DOI Listing

Application of Fresnel Zone Plate Focused Beam to Optimized Sensor Design for Pulse-Echo Harmonic Generation Measurements.

Sensors (Basel) 2019 Mar 19;19(6). Epub 2019 Mar 19.

Department of Mechanical Engineering, Wonkwang University, Iksan, Jeonbuk 54538, Korea.

In nonlinear acoustic measurements involving reflection from the stress-free boundary, the pulse-echo method could not be used because such a boundary is known to destructively change the second harmonic generation (SHG) process. The use of a focusing acoustic beam, however, can improve SHG after reflection from the specimen boundary, and nonlinear pulse-echo methods can be implemented as a practical means of measuring the acoustic nonlinear parameter () of solid specimens. This paper investigates the optimal sensor design for pulse-echo SHG and measurements using Fresnel zone plate (FZP) focused beams. Read More

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http://dx.doi.org/10.3390/s19061373DOI Listing

Modified Cow-Hitch Suture for Repositioning of Subluxated Scleral-Fixated Rigid Intraocular Lens.

Ophthalmic Surg Lasers Imaging Retina 2019 Mar;50(3):179-182

Background And Objective: To describe a new technique for repositioning a subluxated scleral-fixated rigid intraocular lens (IOL).

Patients And Methods: The authors present a modified intraocular threading technique to tie a cow-hitch knot around the eyelet on the dislocated haptic of a scleral-fixated rigid IOL. This technique uses three small corneal incisions to eliminate the need for IOL externalization and minimized the size and number of wounds. Read More

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http://dx.doi.org/10.3928/23258160-20190301-08DOI Listing
March 2019
1 Read

A New Method for Workplace Monitoring of Airborne Diacetyl and 2,3-Pentanedione Using Thermal Desorption Tubes and Gas Chromatography-Mass Spectrometry.

Ann Work Expo Health 2019 Mar 20. Epub 2019 Mar 20.

Analytical Chemistry Team, Health and Safety Executive, Harpur Hill, Buxton, UK.

Diacetyl is a potentially harmful chemical that is used as an artificial flavouring in the food industry and may also be generated during processing of some natural products including coffee. In Europe, an 8-h time weighted average occupational exposure limit (TWA-OEL) of 20 ppb has been adopted for diacetyl, together with a short-term exposure limit (STEL) of 100 ppb. A sensitive new measurement method for diacetyl, and the related compound 2,3-pentanedione has been developed and evaluated. Read More

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http://dx.doi.org/10.1093/annweh/wxz014DOI Listing

Exploring the unintended consequences of learning a new language at a South African university.

Authors:
Mike Murray

PLoS One 2019 20;14(3):e0213973. Epub 2019 Mar 20.

University of KwaZulu-Natal, School of Mathematics, Statistics and Computer Science, Westville Campus, Durban, KwaZulu-Natal, South Africa.

Methodology: This paper uses regression adjustment and entropy matching to achieve an appropriate balance between the two groups. Having achieved this balance any difference in the overall performance between the two groups can then be attributed directly to the new language policy that has been implemented. Our results indicate, after matching, that a significant difference in performance between the two groups occurs with Black African Zulu home language speakers in particular not performing as well as students from the other race and language groups. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213973PLOS

In vitro larval rearing protocol for the stingless bee species Melipona scutellaris for toxicological studies.

PLoS One 2019 20;14(3):e0213109. Epub 2019 Mar 20.

Centro de Estudos de Insetos Sociais-CEIS, Instituto de Biociências, Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP-SP), Rio Claro, SP, Brasil.

Brazil has the highest biodiversity of native stingless bees in the world. However, Brazilian regulations are based on protocols standardized by the Organization for Economic Cooperation and Development (OECD), which uses Apis mellifera as a model organism. The safety of the use of an exotic species as a substitute for a native species is a problem that concerns members of the academy and the government agencies responsible for studies of this nature in the neotropical regions where there are occurrences of stingless bee species. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213109PLOS

Optimal regulation of blood glucose level in Type I diabetes using insulin and glucagon.

PLoS One 2019 20;14(3):e0213665. Epub 2019 Mar 20.

Mechanical Engineering Department, University of New Mexico, Albuquerque, NM 87131, United States of America.

The Glucose-Insulin-Glucagon nonlinear model accurately describes how the body responds to exogenously supplied insulin and glucagon in patients affected by Type I diabetes. Based on this model, we design infusion rates of either insulin (monotherapy) or insulin and glucagon (dual therapy) that can optimally maintain the blood glucose level within desired limits after consumption of a meal and prevent the onset of both hypoglycemia and hyperglycemia. This problem is formulated as a nonlinear optimal control problem, which we solve using the numerical optimal control package [Formula: see text]. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213665PLOS
March 2019
1 Read

Protocol for the reconstruction of micromammals from fossils. Two case studies: The skulls of Beremendia fissidens and Dolinasorex glyphodon.

PLoS One 2019 20;14(3):e0213174. Epub 2019 Mar 20.

Aragosaurus-IUCA, Department of Earth Sciences, University of Zaragoza, Zaragoza, Spain.

We have developed a protocol for reconstructing 3D models of the skulls of extinct species of small mammals. For the first time, the reconstruction uses fragments of fossils from a mixture of different specimens and from related extant species. We use free software and commercial computers to make the process reproducible and usable for the scientific community. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213174PLOS

Cytochrome P450 in Palliative Care and Hospice Kits.

Authors:
Mary Jo Quinn

J Hosp Palliat Nurs 2019 Mar 20. Epub 2019 Mar 20.

Mary Jo Quinn, MS, APRN, NP-C, ACHPN, is nurse practitioner, HouseCalls, Lakeland, Florida.

As hospice and palliative care populations shift from the majority having a primary cancer diagnosis to most with a noncancer diagnosis, clinicians are challenged with caring for chronically ill patients with multiple comorbidities. In addition to traditional pain and symptom management, patients' comfort goals are frequently addressed by managing the underlying disease and comorbid conditions. As a result, many patients have extensive medication profiles. Read More

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http://dx.doi.org/10.1097/NJH.0000000000000524DOI Listing

Pharmacological Attenuation of Electrical Effects in a Model of Compression Neuropathy.

J Bone Joint Surg Am 2019 Mar;101(6):523-530

Department of Orthopaedics and Rehabilitation, Center for Orthopaedic Research and Translational Science, The Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania.

Background: Peripheral nerve compression and entrapment can be debilitating. Using a validated animal model of peripheral nerve compression, we examined the utility of 2 drugs approved for other uses in humans, 4-aminopyridine (4-AP) and erythropoietin (EPO), as treatments for surgically induced ischemia and as adjuvants to surgical decompression.

Methods: Peripheral nerve compression was induced in wild-type mice by placing an inert silicone sleeve around the sciatic nerve. Read More

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http://dx.doi.org/10.2106/JBJS.18.00162DOI Listing

Absolute quantification of noncoding RNA by microscale thermophoresis.

Angew Chem Int Ed Engl 2019 Mar 20. Epub 2019 Mar 20.

Johannes-Gutenberg-Universität Mainz, Institut für Pharmazie und Biochemie, Staudinger Weg 5, Not Available, 55128, Mainz, GERMANY.

Accurate quantification of copy numbers of noncoding RNA has recently emerged as an urgent problem, with impact on fields such as RNA modification research, tissue differentiation, and others. Here we present a hybridization-based approach that uses microscale thermophoresis (MST) as a very fast and highly precise readout to quantify e.g. Read More

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http://dx.doi.org/10.1002/anie.201814377DOI Listing

[Electronic health records in high complexity hospitals: a report on the implementation process from the telehealth perspective].

Cien Saude Colet 2019 Mar;24(3):1133-1142

Instituto de Estudos em Saúde Coletiva, Universidade Federal do Rio de Janeiro. Rio de Janeiro RJ Brasil.

The implementation of electronic records in healthcare establishments has led to isolated solutions, which contribute to the fragmentation of the Brazilian Unified Health System (SUS). This research uses a strategic planning tool in order to monitor the trajectory of implementation of the records in medium and high complexity hospitals, which are a benchmark for the health of women and children. The scope was to outline possible contributions for the computerization of health facilities in general. Read More

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http://dx.doi.org/10.1590/1413-81232018243.05982017DOI Listing

Visible-light promoted aerobic difunctionalization of alkenes with sulfonyl hydrazides for the synthesis of β-keto/hydroxyl sulfones.

Org Biomol Chem 2019 Mar 20. Epub 2019 Mar 20.

School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, PR China. and State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen 361005, P.R. China.

A practical method has been developed for the conversion of alkenes to β-keto/hydroxyl sulfones by their reaction with sulfonyl hydrazides under metal-free conditions. This reaction proceeds through the oxidative addition of alkenes by sulfonyl radicals that are generated by visible-light induced oxidation of sulfonyl hydrazides. Notaly the reaction uses O2 as the terminal oxidant, instead of metal catalysts or oxidants like TBHP, leading to H2O and N2 as the clean by-products. Read More

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http://dx.doi.org/10.1039/c9ob00278bDOI Listing

Enhancing Sketch-Based Image Retrieval by CNN Semantic Re-ranking.

IEEE Trans Cybern 2019 Mar 15. Epub 2019 Mar 15.

This paper introduces a convolutional neural network (CNN) semantic re-ranking system to enhance the performance of sketch-based image retrieval (SBIR). Distinguished from the existing approaches, the proposed system can leverage category information brought by CNNs to support effective similarity measurement between the images. To achieve effective classification of query sketches and high-quality initial retrieval results, one CNN model is trained for classification of sketches, another for that of natural images. Read More

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http://dx.doi.org/10.1109/TCYB.2019.2894498DOI Listing

Multiple Instance Learning for Multiple Diverse Hyperspectral Target Characterizations.

IEEE Trans Neural Netw Learn Syst 2019 Mar 18. Epub 2019 Mar 18.

A practical hyperspectral target characterization task estimates a target signature from imprecisely labeled training data. The imprecisions arise from the characteristics of the real-world tasks. First, accurate pixel-level labels on training data are often unavailable. Read More

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http://dx.doi.org/10.1109/TNNLS.2019.2900465DOI Listing

Scalable Digital Neuromorphic Architecture for Large-Scale Biophysically Meaningful Neural Network With Multi-Compartment Neurons.

IEEE Trans Neural Netw Learn Syst 2019 Mar 18. Epub 2019 Mar 18.

Multicompartment emulation is an essential step to enhance the biological realism of neuromorphic systems and to further understand the computational power of neurons. In this paper, we present a hardware efficient, scalable, and real-time computing strategy for the implementation of large-scale biologically meaningful neural networks with one million multi-compartment neurons (CMNs). The hardware platform uses four Altera Stratix III field-programmable gate arrays, and both the cellular and the network levels are considered, which provides an efficient implementation of a large-scale spiking neural network with biophysically plausible dynamics. Read More

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http://dx.doi.org/10.1109/TNNLS.2019.2899936DOI Listing

Self-Tuning Neural Predictive Control Scheme for Ultrabattery to Emulate a Virtual Synchronous Machine in Autonomous Power Systems.

IEEE Trans Neural Netw Learn Syst 2019 Mar 18. Epub 2019 Mar 18.

An adaptive neural predictive controller (ANPC) is proposed for an ultrabattery energy storage system (UBESS) to enable its operation as a virtual synchronous machine (VSM) in an autonomous wind-diesel power system. The proposed VSM emulates the inertial response and oscillation damping capability of a typical synchronous machine (employed in conventional power plants) by adaptively controlling the power electronic interface of the UBESS. The control objective is to support the network frequency while ensuring efficient/economic use of the UBESS energy. Read More

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http://dx.doi.org/10.1109/TNNLS.2019.2899904DOI Listing

Implementing a concept network model.

Behav Res Methods 2019 Mar 19. Epub 2019 Mar 19.

Department of Psychology, University of Pennsylvania, Philadelphia, PA, USA.

The same concept can mean different things or be instantiated in different forms, depending on context, suggesting a degree of flexibility within the conceptual system. We propose that a feature-based network model can be used to capture and predict this flexibility. We modeled individual concepts (e. Read More

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http://dx.doi.org/10.3758/s13428-019-01217-1DOI Listing

Microbial Ecology of the Western Gull (Larus occidentalis).

Microb Ecol 2019 Mar 20. Epub 2019 Mar 20.

Department of Biological Sciences, San José State University, One Washington Square, San Jose, CA, 95192-0100, USA.

Avian species host diverse communities of microorganisms which have important roles in the life of birds, including increased metabolism, protection from disease, and immune system development. Along with high human populations and a diversity of human uses of coastal zones, anthropogenic food sources are becoming increasingly available to some species, including gulls. Anthropogenic associations increase the likelihood of encountering foreign or pathogenic bacteria. Read More

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http://link.springer.com/10.1007/s00248-019-01352-4
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http://dx.doi.org/10.1007/s00248-019-01352-4DOI Listing
March 2019
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Disability-based disparity in outpatient health system responsiveness among the older adults in low- to upper-middle-income countries.

Health Policy Plan 2019 Mar 19. Epub 2019 Mar 19.

Indian Institute of Science Education and Research Thiruvananthapuram, Vithura, Thiruvananthapuram, India.

Health system responsiveness (HSR) has been identified as one of the intrinsic goals of health systems for improvement in health and well-being of population. The HSR deals with the non-medical, legitimate expectations of a population in its interaction with the health system. It becomes essential in case of vulnerable groups like older adults with disability, who are more sensitive and risk-prone to the adversities of healthcare challenges. Read More

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http://dx.doi.org/10.1093/heapol/czz013DOI Listing

Robust segmentation of retinal layers in optical coherence tomography images based on a multistage active contour model.

Heliyon 2019 Feb 28;5(2):e01271. Epub 2019 Feb 28.

Department of Computing, University of A Coruña, 15071, A Coruña, Spain.

Optical Coherence Tomography (OCT) constitutes an imaging technique that is increasing its popularity in the ophthalmology field, since it offers a more complete set of information about the main retinal structures. Hence, it offers detailed information about the eye fundus morphology, allowing the identification of many intraretinal pathological signs. For that reason, over the recent years, Computer-Aided Diagnosis (CAD) systems have spread to work with this image modality and analyze its information. Read More

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http://dx.doi.org/10.1016/j.heliyon.2019.e01271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401526PMC
February 2019

Computationally effective 2D and 3D fast phase unwrapping algorithms and their applications to Doppler optical coherence tomography.

Biomed Opt Express 2019 Mar 21;10(3):1365-1382. Epub 2019 Feb 21.

Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University in Torun, Grudziadzka 5, 87-100 Torun, Poland.

We propose a simplification for a robust and easy to implement fast phase unwrapping (FPU) algorithm that is used to solve the phase wrapping problem encountered in various fields of optical imaging and metrology. We show that the number of necessary computations using the algorithm can be reduced compared to its original version. FPU can be easily extended from two to three spatial dimensions. Read More

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http://dx.doi.org/10.1364/BOE.10.001365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420292PMC

One-step deconvolution for multi-angle TIRF microscopy with enhanced resolution.

Biomed Opt Express 2019 Mar 5;10(3):1097-1110. Epub 2019 Feb 5.

Key Laboratory of Image Processing and Intelligent Control of Ministry of Education of China, School of Automation, Huazhong University of Science and Technology, Wuhan 430074, China.

Total internal reflection fluorescence microscopy (TIRF microscopy) uses a rapid decay of evanescent waves to excite fluorophores within several hundred nanometers () beneath the plasma membrane, which can effectively suppress excitation of fluorescence signals in the deep layers. From image stacks obtained with a plurality of different incident angles, a three-dimensional spatial structure of the observed sample can be reconstructed by a Multi-Angle-TIRF (MA-TIRF) algorithm that provides an axial resolution of ~50 . Taking into account the point spread function (PSF) of the TIRF microscopes, we further increase its lateral resolution by introducing a fast deconvolution algorithm into the reconstruction of MA-TIRF data (DMA-TIRF), which is approached in just one step of minimizing the reconstruction function. Read More

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http://dx.doi.org/10.1364/BOE.10.001097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420288PMC