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Front Med (Lausanne) 2022 29;9:796109. Epub 2022 Apr 29.

Department of Infectology, Central Hospital of Southern Pest National Institute of Haematology and Infectious Diseases, Budapest, Hungary.

Background: Dysregulation of complement system is thought to be a major player in development of multi-organ damage and adverse outcomes in patients with coronavirus disease 2019 (COVID-19). This study aimed to examine associations between complement system activity and development of severe acute kidney injury (AKI) among hospitalized COVID-19 patients.

Materials And Methods: In this multicenter, international study, complement as well as inflammatory and thrombotic parameters were analyzed in COVID-19 patients requiring hospitalization at one US and two Hungarian centers. Read More

Front Med (Lausanne) 2022 29;9:866494. Epub 2022 Apr 29.

Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.

Background: The clinical features and outcomes of viral respiratory tract infections (RTIs) in adults have not been thoroughly studied, especially the respiratory syncytial virus (RSV) disease burden. It has become apparent that outbreaks of RSV in the elderly are associated with increased hospitalization rates. However, little data exists on the severity of such viral RTIs in adults, particularly the need for hospitalization, respiratory support and intensive care. Read More

J Am Coll Emerg Physicians Open 2022 Jun 5;3(3):e12739. Epub 2022 May 5.

Division of Cardiology Columbia University Irving Medical Center New York City New York USA.

Study Objective: To evaluate whether the introduction of a 1-hour high-sensitivity cardiac troponin-T (hs-TnT) pathway for patients who present to the emergency department (ED) with suspected acute coronary syndrome (ACS) improves ED patient flow without changing the rate of "missed" major adverse cardiac events (MACE), compared to use of conventional cardiac troponin with an associated 3-hour pathway.

Methods: This was a prospective, uncontrolled observational study conducted before and after implementation of a 1-hour hs-TnT pathway at a high-volume urban ED. Patients undergoing evaluation for ACS in the ED were enrolled during their initial visit and clinical outcomes were assessed at 30 and 90 days. Read More

Clin Ther 2022 May 12. Epub 2022 May 12.

Department of Cardiac Surgery, Medstar Health, Washington, DC.

Background: Cardiac rehabilitation (CR) improves major adverse cardiac outcomes in patients recovering from myocardial infarction. CR influences outcomes through attenuation of cardiac risk factors, lifestyle changes, and biological effects on endothelial function. The clinical profile and sex-specific outcomes with CR after coronary artery bypass grafting (CABG) is less well defined. Read More

Heart Fail Rev 2022 May 10. Epub 2022 May 10.

Fondazione Toscana Gabriele Monasterio, Pisa, Italy.

Cardiac magnetic resonance (CMR) has become an essential tool for the evaluation of patients affected or at risk of developing cardiomyopathies (CMPs). In fact, CMR not only provides precise data on cardiac volumes, wall thickness, mass and systolic function but it also a non-invasive characterization of myocardial tissue, thus helping the early diagnosis and the precise phenotyping of the different CMPs, which is essential for early and individualized treatment of patients. Furthermore, several CMR characteristics, such as the presence of extensive LGE or abnormal mapping values, are emerging as prognostic markers, therefore helping to define patients' risk. Read More

Appl Bionics Biomech 2022 29;2022:6077429. Epub 2022 Apr 29.

Department of Emergency, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan 030032, China.

Objective: LCZ696 (sacubitril/valsartan) is an angiotensin II (Ang II) type 1 receptor-neprilysin inhibitor, with effects of immunosuppression, anti-inflammation, antiapoptosis, and antioxidation. The present study was aimed at determining whether LCZ696 has a protective effect against isoproterenol-induced acute heart failure (AHF) in rats.

Methods: SD rats were randomly divided into four groups: control group, HF group, LCZ696 group, and enalapril group. Read More

Exp Ther Med 2022 Jun 5;23(6):371. Epub 2022 Apr 5.

Department of Emergency, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233030, P.R. China.

The present study aimed to investigate the cardioprotective role of berberine in sepsis-induced cardiac dysfunction and consider the underlying mechanisms. C57BL/6J mice were randomized into four groups, namely, Control, lipopolysaccharide (LPS), LPS + berberine and LPS + N-nitro-L-arginine methyl ester (L-NAME) + berberine. A single dose (10 mg/kg body weight) of LPS was intraperitoneally administered to mice to induce cardiac dysfunction, whereas the Control group was administered with an equivalent volume of saline. Read More

Ulus Travma Acil Cerrahi Derg 2022 May;28(5):599-606

Department of Biostatistics, Eskişehir Osmangazi University Faculty of Medicine, Eskişehir-Turkey.

Background: Lactate and base deficit (BD) values are parameters evaluated as indicators of tissue perfusion and have been used as markers of severity of injury and mortality.

Objectives: The aim of the study was to determine the relationship between combined score (CS) and blood transfusion need within 24 h and comparison of the variables between transfusion and non-transfusion group, correlation lactate with BD and with physiological, laboratory parameters, and determining the major risk factors of patients for the need for blood transfusion.

Methods: The study included a total of 359 patients (245 males, median age: 40, min-max: 18-95) with blunt multi-trauma. Read More

J Clin Med 2022 Apr 16;11(8). Epub 2022 Apr 16.

Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.

The neutrophil-to-lymphocyte ratio (NLR) is an inflammatory marker predicting the prognosis of several diseases. We aimed to assess its role as a predictor of mortality or admission to the intensive care unit in COVID-19 patients. We retrospectively evaluated a cohort of 411 patients with COVID-19 infection. Read More

J Clin Med 2022 Apr 7;11(8). Epub 2022 Apr 7.

Department of Interventional Cardiology, Institute of Cardiology, Jagiellonian University Medical College, Prądnicka 80 Str., 31-202 Krakow, Poland.

Background: The resistive (RI) and pulsatile (PI) indices are markers of vascular stiffness (VS) which are associated with outcomes in patients with cardiovascular disease. We aimed to assess whether VS might predict incidence of cardiovascular death (CVD) and heart failure (HF) episodes following intervention on degenerative aortic valve stenosis (DAS).

Methods: The distribution of increased VS (RI ≥ 0. Read More

Diagnostics (Basel) 2022 Mar 27;12(4). Epub 2022 Mar 27.

Department of Obstetrics and Gynecology, "Victor Babes" University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania.

COVID-19 has been associated with cardiovascular consequences, including myocardial infarction, thromboembolic events, arrhythmia, and heart failure. Numerous overlapping mechanisms, such as the IL-6 dependent cytokine storm and unopposed angiotensin II stimulation, could be responsible for these consequences. Cardiac damage is hypothesized to be a consequence of the direct viral infection of cardiomyocytes, resulting in increased metabolic demand, immunological activation, and microvascular dysfunction. Read More

JACC Clin Electrophysiol 2022 Apr 30;8(4):411-423. Epub 2022 Mar 30.

Department of Emergency Medicine, Oregon Health and Science University, Portland, Oregon, USA.

Objectives: This study aimed to develop a novel clinical prediction algorithm for avertable sudden cardiac death.

Background: Sudden cardiac death manifests as ventricular fibrillation (VF)/ ventricular tachycardia (VT) potentially treatable with defibrillation, or nonshockable rhythms (pulseless electrical activity/asystole) with low likelihood of survival. There are no available clinical risk scores for targeted prediction of VF/VT. Read More

Pol Merkur Lekarski 2022 Apr;50(296):73-77

Department of Anesthetics, Intensive Care and Emergency Medicine, Collegium Medicum, University of Zielona Gora, Poland.

Chronic heart failure is a complex clinical syndrome with increasing significance in the ageing societies of developed countries. Recent advances in both medical and instrumental therapy improve the prognosis of heart failure patients which, nevertheless, remains poor. Patients suffer from progressive pump failure reflected in increasing incidence of hospital admissions as well as sudden death due to electrical imbalance of diseased myocardium. Read More

J Am Coll Emerg Physicians Open 2022 Apr 9;3(2):e12695. Epub 2022 Apr 9.

Department of Emergency Medicine Wayne State University Detroit Michigan USA.

Background: Prior data has demonstrated increased mortality in hospitalized patients with acute heart failure (AHF) and troponin elevation. No data has specifically examined the prognostic significance of troponin elevation in patients with AHF discharged after emergency department (ED) management.

Objective: Evaluate the relationship between troponin elevation and outcomes in patients with AHF who are treated and released from the ED. Read More

Dis Markers 2022 1;2022:9309444. Epub 2022 Feb 1.

Emergency Department, Guizhou Province, The Affiliated Hospital of Guizhou Medical University, No. 28, Guiyijie Road, Liuguangmen, Guiyang City 550004, China.

Purpose: Cardiac complications are common in patients with spontaneous intracerebral hemorrhage (ICH). The present study is aimed at observing the incidence of cardiac complications after ICH, so as at improving the understanding of the relationship between cardiac complications and ICH.

Methods: This is a retrospective study on analyzing electrocardiogram (ECG) and serum myocardial enzyme of 208 patients with ICH admitted to a tertiary hospital from 2018 to 2019. Read More

Peptides 2022 Apr 12;153:170800. Epub 2022 Apr 12.

Department of Cardiovascular Medicine, East Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address:

Midkine levels are related to various diseases, including cardiovascular disease, renal disease and autoimmune disease. The research aimed to investigate the mitigation influence of downregulation of intermediate factors on myocardial hypertrophy induced by angiotensin Ⅱ (Ang), and whether downregulation of midkine could attenuate oxidative stress and autophagy. Induced myocardial hypertrophy of the mice model and treated HL-1 cells with Ang Ⅱ in vitro. Read More

Inflammation 2022 Apr 11. Epub 2022 Apr 11.

Emergency Medicine Department, Medical School, University of São Paulo, Av. Dr. Arnaldo, 455 - Cerqueira César, São Paulo, São Paulo, CEP, 01246-903, Brazil.

Cardiomyopathy is a well-known complication of sepsis that may deteriorate when accompanied by obesity. To test this hypothesis we fed C57black/6 male mice for 6 week with a high fat diet (60% energy) and submitted them to endotoxemic shock using E. coli LPS (10 mg/kg). Read More

Open Heart 2022 Apr;9(1)

Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Medicine, Gothemburg, Sweden.

Background: Body iron stores (BISs) have been proposed to be related to the development of cardiovascular diseases. However, results from epidemiological studies are conflicting. Knowledge on the long-term impact of BIS on cardiovascular outcomes in the general population is lacking. Read More

Curr Cardiol Rev 2022 Apr 11. Epub 2022 Apr 11.

University of Peradeniya, Sri Lanka.

Acute coronary syndrome is the main cause of mortality and morbidity worldwide and early diagnosis is a challenge for clinicians. Though cardiac Troponin, the most commonly used biomarker is the gold standard for myocardial necrosis, it is blind for ischemia without necrosis. Therefore, ideal biomarkers are essential in the care of patients presenting with symptoms suggestive of cardiac ischemia. Read More

Cureus 2022 Mar 7;14(3):e22926. Epub 2022 Mar 7.

Department of Cardiology, University Hospitals Cleveland Medical Center, Cleveland, USA.

Recently, coronavirus disease 2019 (COVID-19, caused by SARS-CoV-2) has posed a challenge for clinicians, particularly extrapulmonary manifestations. These manifestations are often rare and difficult to recognize as research is still underway for the myriad presentations of the disease. A 19-year-old man presented with viral upper respiratory infection (URI) symptoms and received a positive result for SARS-CoV-2 real-time reverse transcription polymerase chain testing. Read More

Cureus 2022 Feb 28;14(2):e22703. Epub 2022 Feb 28.

Cardiology, Al Jufairi Diagnosis And Treatment, Doha, QAT.

The definition of myocardial infarction was updated in 2000 to include an elevation of cardiac troponin T or I (cTnT or xTnI) alongside clinical evidence of myocardial infarction. The redefinition was jointly done by the American College of Cardiology Committee and the European Society of Cardiology. Since then, cardiac troponin T and I have assumed the position as the primary biochemical markers for diagnosing myocardial infarction. Read More

BMJ Open 2022 Apr 5;12(4):e056798. Epub 2022 Apr 5.

Department of Intensive Care, University Hospital, Basel, Switzerland

Objectives: Guidelines recommend family presence to be offered during cardiopulmonary resuscitation (CPR). Data on the effects of family presence on the quality of CPR and rescuers' workload and stress levels are sparse and conflicting. This randomised trial investigated the effects of family presence on quality of CPR, and rescuers' perceived stress. Read More

Pediatr Emerg Care 2022 May 22;38(5):e1237-e1244. Epub 2021 Nov 22.

From the Division of Emergency Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL.

Objectives: This study aimed to evaluate trends in pediatric emergency department (ED) 72-hour return visits and factors associated with return visits.

Methods: We performed a cross-sectional study from 2002 to 2018 using the National Hospital Ambulatory Medical Care Survey, a complex survey of nonfederal US ED encounters. Patients 18 years or older were excluded. Read More

Dis Markers 2022 28;2022:9713326. Epub 2022 Mar 28.

County Emergency Hospital Cluj-Napoca, Medical Clinic No. 1, Interventional Cardiology Department, Romania.

The use of high-sensitivity cardiac troponin (hs-cTn) assays has become part of the daily practice in most of the laboratories worldwide in the initial evaluation of the typical chest pain. Due to their early surge, the use of hs-cTn may reduce the time needed to recognise myocardial infarctions (MI), which is vital for the patients presenting in the emergency departments for chest pain. The latest European Society of Cardiology Guidelines did not only recognise their central role in the diagnosis algorithm but also recommended their use for rapid rule-in/rule-out of MI. Read More

J Healthc Eng 2022 19;2022:4008966. Epub 2022 Mar 19.

Department of Hypertension, Jinan Municipal Hospital of Traditional Chinese Medicine, Jinan 250012, China.

Objective: To investigate the efficacy of the application of Buqi Huoxue Decoction combined with cardiac rehabilitation nursing for patients with acute ST-segment elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI) and its influence on the prognosis.

Methods: 120 STEMI patients undergoing PCI were randomly divided into control group, cardiac care group, traditional Chinese medicine and western medicine group (TCM + WM group), and comprehensive treatment group. The control group was treated with a conventional antiplatelet therapy. Read More

Resuscitation 2022 May 21;174:42-46. Epub 2022 Mar 21.

Departments of Emergency Medicine, Critical Care Medicine, and Neurology, University of Pittsburgh, Pittsburgh, PA, USA.

Introduction: Metformin is a first-line diabetic therapy that improves survival in a wide number of ischemic pathologies. We tested the association of metformin with markers of cardiac and renal injury in diabetic post-arrest patients.

Methods: We performed a retrospective analysis of clinical outcomes in diabetic cardiac arrest patients with and without metformin therapy at a single academic medical center. Read More

J Cardiovasc Dev Dis 2022 Feb 24;9(3). Epub 2022 Feb 24.

Cardiology Section, Hospital "F. Perinei", 70022 Bari, Italy.

The impact of sex on the assessment of congestion in acute heart failure (AHF) is still a matter of debate. The objective of this analysis was to evaluate sex differences in the evaluation of congestion at admission in patients hospitalized for AHF. We consecutively enrolled 494 AHF patients (252 female). Read More

Pediatr Res 2022 Mar 23. Epub 2022 Mar 23.

Grupo Investigación GC12 Clinical and Epidemiological Research in Primary Care, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), 14071, Córdoba, Spain.

Background: Elevated body mass index (BMI) has been associated with cardiac changes, such as higher epicardial adipose tissue (EAT) thickness. This fat has been identified as a predictive factor of cardiovascular diseases during adulthood. However, few studies have tested the association of multiple cardiovascular risk factors (high weight or blood pressure) with EAT in adolescents and children. Read More

Front Pediatr 2022 7;10:832391. Epub 2022 Mar 7.

Institute for Maternal and Child Health Istituto di Ricerca e Cura a Carattere Scientifico (IRCCS) "Burlo Garofolo", Trieste, Italy.

Introduction: Multisystem inflammatory syndrome in children (MIS-C) is a new clinical entity characterized by a systemic hyperinflammation triggered by SARS-CoV-2 infection in children and adolescents. This condition could potentially involve all organs with main complications concerning cardiovascular system. Despite up to 90% of patients complain gastrointestinal symptoms (nausea, vomit, and diarrhea), a presentation mimicking acute appendicitis has rarely been reported, and can be the presenting feature of the disease, potentially leading to misdiagnosis and delayed treatment. Read More

Pediatr Cardiol 2022 Mar 22. Epub 2022 Mar 22.

Pediatric Emergency Unit, Scientific Institute for Research and Healthcare (IRCCS), Sant'Orsola University Hospital, Via Massarenti, 11, Bologna, Italy.

Psoriasis is a skin disorder which mostly affects adults, beginning in childhood in almost one-third of patients. In adults it is associated with increased risk for cardiovascular diseases (CVD), while this association is still debated at younger age. Our aim was to evaluate the association between psoriasis and metabolic markers and cardiovascular findings in this age group. Read More