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    752 results match your criteria Use of Cardiac Markers in the Emergency Department

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    Early gestational age at preeclampsia onset is associated with subclinical atherosclerosis 12 years after delivery.
    Acta Obstet Gynecol Scand 2017 May 23. Epub 2017 May 23.
    Institute of Clinical Medicine, Aarhus University, Aarhus.
    Introduction: Women with a history of preeclampsia have increased risk of cardiovascular disease later in life. However, it is unclear if early gestational age at preeclampsia onset is associated with higher cardiovascular disease risk. This study aimed to test the association between gestational age at preeclampsia onset (including the early-onset/late-onset preeclampsia distinction) and subclinical atherosclerosis and arterial stiffness in age-matched women 12 years after index pregnancy MATERIAL AND METHODS: Eligible participants were identified in two Danish registries. Read More

    Effect of high-dose sodium selenite in cardiac surgery patients: A randomized controlled bi-center trial.
    Clin Nutr 2017 May 2. Epub 2017 May 2.
    Department for Anesthesia, Intensive Care Medicine and Rescue Medicine, Lucerne Cantonal Hospital, Lucerne, Switzerland; Department of Anesthesiology and Intensive Care Medicine, Hirslanden Clinic, Zürich, Switzerland. Electronic address:
    Background & Aims: Cardiac surgery is accompanied by oxidative stress and systemic inflammatory response, which may be associated with organ dysfunction and increased mortality. Selenium and selenoenzymes are important constituents of anti-oxidative defense. We hypothesized that high-dose sodium selenite supplementation can attenuate the postoperative inflammation and might, therefore, improve clinical outcome. Read More

    Novel biomarkers for cardiovascular risk prediction.
    J Geriatr Cardiol 2017 Feb;14(2):135-150
    Department of Cardiology Internal Medicine, Nanlou Branch of Chinese PLA General Hospital, Beijing, China.
    Cardiovascular disease (CVD) is the leading cause of death and disability worldwide. The primary prevention of CVD is dependent upon the ability to identify high-risk individuals long before the development of overt events. This highlights the need for accurate risk stratification. Read More

    Markers of diuretic resistance in emergency department patients with acute heart failure.
    Int J Emerg Med 2017 Dec 8;10(1):17. Epub 2017 May 8.
    Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
    Background: Loop diuretics are common therapy for emergency department (ED) patients with acute heart failure (AHF). Diuretic resistance (DR) is a term used to describe blunted natriuretic response to loop diuretics. It would be important to detect DR prior to it becoming clinically apparent, so early interventions can be initiated. Read More

    Disseminated intravascular coagulation is associated with the neurologic outcome of cardiac arrest survivors.
    Am J Emerg Med 2017 May 1. Epub 2017 May 1.
    Department of Emergency Medicine, Chonnam National University Hospital, 42 Jebong-ro, Donggu, Gwangju, Republic of Korea.
    Purpose: We aimed to examine the serial changes in coagulofibrinolytic markers that occurred after the restoration of spontaneous circulation (ROSC) in cardiac arrest patients, who were treated with targeted temperature management (TTM). We also evaluated the association between the disseminated intravascular coagulation (DIC) score and clinical outcomes.

    Methods: This was a single-centre, retrospective observational study that included cardiac arrest patients who were treated with TTM from May 2012 to December 2015. Read More

    Lp-PLA2 activity and mass for prediction of incident abdominal aortic aneurysms: A prospective longitudinal cohort study.
    Atherosclerosis 2017 Apr 21;262:14-18. Epub 2017 Apr 21.
    Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden; Department of Heart Failure and Valvular Disease, Skåne University Hospital, Lund, Sweden.
    Background And Aims: The pathogenesis of abdominal aortic aneurysm (AAA) shares several common pathways with atherosclerosis. Prospective clinical plasma biomarker studies in AAA have been hampered by the need for very large cohorts and long follow-up time.

    Methods: We analyzed a prospective longitudinal cohort of middle-aged individuals from the cardiovascular cohort of the Malmö Diet and Cancer study (n = 5551; 1991-94). Read More

    Utilization Criteria for Prehospital Ultrasound in a Canadian Critical Care Helicopter Emergency Medical Service: Determining Who Might Benefit.
    Prehosp Disaster Med 2017 May 3:1-5. Epub 2017 May 3.
    2Shock Trauma Air Rescue Society,Edmonton,Alberta,Canada.
    Introduction Prehospital ultrasound (PHUS) assessments by physicians and non-physicians are performed on medical and trauma patients with increasing frequency. Prehospital ultrasound has been shown to be of benefit by supporting interventions. Problem Which patients may benefit from PHUS has not been clearly identified. Read More

    Clinical course and prognostic factors of patients in severe accidental hypothermia with circulatory instability rewarmed with veno-arterial ECMO - an observational case series study.
    Scand J Trauma Resusc Emerg Med 2017 May 2;25(1):46. Epub 2017 May 2.
    Department of Anesthesiology and Intensive Care, the John Paul II Hospital, Medical College of Jagiellonian University, Cracow, Poland.
    Background: Recently, veno-arterial extracorporeal membrane oxygenation (VA-ECMO) has become the rewarming treatment of choice in hypothermic cardiac arrest. The detailed indications for extracorporeal rewarming in non-arrested, severely hypothermic patients with circulatory instability have not been established yet. The primary purpose of the study was a preliminary analysis of all aspects of the treatment process, as well as initial identification of mortality risk factors within the group of severely hypothermic patients, treated with arteriovenous extracorporeal membrane oxygenation (VA-ECMO). Read More

    Acute stress in residents during emergency care: a study of personal and situational factors.
    Stress 2017 May 19:1-8. Epub 2017 May 19.
    b Emergency Department , Hospital das Clínicas, University of São Paulo Medical School , São Paulo , Brazil.
    Providing care for simulated emergency patients may induce considerable acute stress in physicians. However, the acute stress provoked in a real-life emergency room (ER) is not well known. Our aim was to assess acute stress responses in residents during real emergency care and investigate the related personal and situational factors. Read More

    Chest compliance is altered by static compression and decompression as revealed by changes in anteroposterior chest height during CPR using the ResQPUMP in a human cadaver model.
    Resuscitation 2017 Apr 28;116:56-59. Epub 2017 Apr 28.
    Department of Emergency Medicine, University of Minnesota, Minneapolis, MN, United States; ZOLL Medical, Minneapolis, MN, United States. Electronic address:
    Introduction: Chest compliance plays a fundamental role in the generation of circulation during cardiopulmonary resuscitation (CPR). To study potential changes in chest compliance over time, anterior posterior (AP) chest height measurements were performed on newly deceased (never frozen) human cadavers during CPR before and after 5min of automated CPR. We tested the hypothesis that after 5min of CPR chest compliance would be significantly increased. Read More

    E2/ER β Enhances Calcineurin Protein Degradation and PI3K/Akt/MDM2 Signal Transduction to Inhibit ISO-Induced Myocardial Cell Apoptosis.
    Int J Mol Sci 2017 Apr 24;18(4). Epub 2017 Apr 24.
    Graduate Institute of Basic Medical Science, China Medical University, Taichung 40402, Taiwan.
    Secretion of multifunctional estrogen and its receptor has been widely considered as the reason for markedly higher frequency of heart disease in men than in women. 17β-Estradiol (E2), for instance, has been reported to prevent development of cardiac apoptosis via activation of estrogen receptors (ERs). In addition, protein phosphatase such as protein phosphatase 1 (PP1) and calcineurin (PP2B) are also involved in cardiac hypertrophy and cell apoptosis signaling. Read More

    Proteomics in Hypothermia as Adjunctive Therapy in Patients with ST-Segment Elevation Myocardial Infarction: A CHILL-MI Substudy.
    Ther Hypothermia Temp Manag 2017 Mar 2. Epub 2017 Mar 2.
    1 Department of Cardiology and Clinical Sciences, Skåne University Hospital, Lund University , Lund, Sweden .
    Cardiovascular and inflammatory biomarkers in therapeutic hypothermia have been studied in cardiac arrest, but data on patients with ST-segment elevation myocardial infarction (STEMI) treated with therapeutic hypothermia are currently unavailable. A multiplex proximity extension assay allowed us to measure 157 cardiovascular disease (CVD) and inflammatory disease-related biomarkers in patients from the international, multicenter, and randomized trial; CHILL-myocardial infarction (MI) and to explore the associations of cardiovascular and inflammatory biomarkers. Blood samples were obtained from 119 patients with STEMI, randomized to hypothermia as adjunctive therapy to percutaneous coronary intervention (PCI) or standard care with PCI only. Read More

    Diagnostic value of copeptin in acute myocardial infarction.
    Eur Rev Med Pharmacol Sci 2017 Apr;21(7):1576-1582
    Department of Emergency Medicine, Hitit University, Corum Training and Research Hospital, Corum, Turkey.
    Objective: The aim of this study was to investigate the effectiveness of copeptin in the early diagnosis of acute myocardial infarction (AMI), and to compare the diagnostic efficacy of copeptin with other cardiac markers.

    Patients And Methods: A total of 160 cases were enrolled in the study. All were over 18 years of age, and consisted of 54 non-ST elevation MI (NSTEMI), 54 ST segment elevation MI (STEMI), and 52 healthy subjects (controls). Read More

    Pheochromocytoma of the Organ Zuckerkandl.
    J La State Med Soc 2017 Mar-Apr;169(2):53. Epub 2017 Apr 15.
    Department of Internal Medicine, LSU Health Sciences Center, New Orleans, LA.
    Introduction: Pheochromocytomas (PCCs);, or intra-adrenal paragangliomas (PGLs);, are neuroendocrine tumors arising within the adrenal medulla. Extra-adrenal paragangliomas may arise in the sympathetic or parasympathetic paraganglia and more rarely in other organs. One of the most common extra-adrenal sites is in the organ of Zuckerkandl, a collection of chromaffin cells near the origin of the inferior mesenteric artery or near the aortic bifurcation. Read More

    Protective effects of tanshinone IIA sodium sulfonate on ischemia-reperfusion-induced myocardial injury in rats.
    Iran J Basic Med Sci 2017 Mar;20(3):308-315
    Department of Physiology, Medical College of Soochow University, 199 Ren-Ai Road, Dushu Lake Campus, Suzhou Industrial Park, Suzhou 215123, P.R. China.
    Objectives: This study investigated the protective effect of tanshinone IIA sodium sulfonate (TSS) on ischemia-reperfusion (I/R) induced cardiac injury, and the underlying mechanism of action.

    Materials And Methods: Male Sprague-Dawley rats were subjected to a 30-min coronary arterial occlusion followed by 24 hours' reperfusion. Half an hour before the left coronary artery ligation, rats were pretreated with TSS in three different dosages (15, 30, 70 mg/kg, IP). Read More

    Emergency Department Vital Signs and Outcomes after Discharge.
    Acad Emerg Med 2017 Apr 4. Epub 2017 Apr 4.
    Department of Medicine, University of California, Los Angeles, California.
    Objective: Vital signs are critical markers of illness severity in the Emergency Department (ED). Providers need to understand the abnormal vital signs in older adults that are problematic. We hypothesized that in patients age > 65 years discharged from the ED, there are abnormal vital signs that are associated with an admission to an inpatient bed within 7 days of discharge. Read More

    Assessment of macro- and micro-oxygenation parameters during fractional fluid infusion: A pilot study.
    J Crit Care 2017 Mar 27;40:91-98. Epub 2017 Mar 27.
    Pôle Réanimations Anesthésie SAMU/SMUR, CHU de Caen, Avenue de la Côte de Nacre, CS 30001, F-14 000 Caen, France; EA 4650, Université de Caen Normandie, Esplanade de la Paix, CS 14 032, F-14 000 Caen, France. Electronic address:
    Purpose: The main goal of this study was to assess whether maximal fluid infusion improves both oxygen delivery (DO2) and micro-circulatory parameters during hemodilution. The secondary objective was to assess the ability of baseline micro-circulatory parameters to predict oxygen consumption (VO2) response following fluid infusion.

    Materials And Methods: In a postoperative cardiac ICU, patients received repeated fluid infusion until stroke volume (SV) was maximized. Read More

    Association between bystander cardiopulmonary resuscitation and redeemed prescriptions for antidepressants and anxiolytics in out-of-hospital cardiac arrest survivors.
    Resuscitation 2017 Jun 29;115:32-38. Epub 2017 Mar 29.
    Department of Anesthesiology and Intensive Care Medicine, Aalborg University Hospital, Denmark; Department of Clinical Medicine, Aalborg University, Denmark.
    Aim: This study aimed to examine rates of redeemed prescriptions of antidepressants and anxiolytics, used as markers for cerebral dysfunction in out-of-hospital cardiac arrest (OHCA) survivors, and examine the association between bystander CPR and these psychoactive drugs.

    Methods: We included all 30-day survivors of OHCA in Denmark between 2001 and 2011, who had not redeemed prescriptions for antidepressants or anxiolytics in the last six months prior to OHCA. Main outcome measures were redeemed prescriptions of antidepressants and anxiolytics within one year after OHCA. Read More

    Basophils, high-affinity IgE receptors, and CCL2 in human anaphylaxis.
    J Allergy Clin Immunol 2017 Mar 22. Epub 2017 Mar 22.
    University Hospital of Respiratory and Allergic Diseases, Golnik, Slovenia.
    Background: The role of basophils in anaphylaxis is unclear.

    Objective: We sought to investigate whether basophils have an important role in human anaphylaxis.

    Methods: In an emergency department study we recruited 31 patients with acute anaphylaxis, predominantly to Hymenoptera venom. Read More

    Paediatric high-flow nasal cannula therapy in children with bronchiolitis: A retrospective safety and efficacy study in a non-tertiary environment.
    Emerg Med Australas 2017 Apr;29(2):198-203
    Department of Emergency Medicine and Children's Service, The Prince Charles Hospital, Brisbane, Queensland, Australia.
    Objective: The objective was to examine the safety and efficacy of high-flow nasal cannula (HFNC) therapy for children with bronchiolitis in a non-tertiary paediatric setting.

    Methods: This was a single-centre retrospective study conducted over 26 months (March 2013-April 2015) on children aged 1-23 months with suspected bronchiolitis, who commenced on HFNC therapy in either the ED or the ward. Changes with respect to baseline data were analysed for effect on work of breathing (WOB), heart rate (HR) and respiratory rate (RR). Read More

    Review of Prospects of Biological Fluid Biomarkers in Osteoarthritis.
    Int J Mol Sci 2017 Mar 12;18(3). Epub 2017 Mar 12.
    Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon 24252, Korea.
    Osteoarthritis (OA) is a degenerative disease of the joints and is one of the leading causes of disability in adults. However, there are no key therapeutics for OA and medical treatment is based on managing the symptoms and slowing down progression of the disease. Diagnostics based on clinical examination and radiography have provided little information about metabolic changes in joint tissues, disease onset and progression. Read More

    Inflammatory and metalloproteinases profiles predict three-month poor outcomes in ischemic stroke treated with thrombolysis.
    J Cereb Blood Flow Metab 2017 Jan 1:271678X17695572. Epub 2017 Jan 1.
    3 Stroke Unit, Careggi University Hospital, Florence, Italy.
    Inflammatory mediators and metalloproteinases are altered in acute ischemic stroke (AIS) and play a detrimental effect on clinical severity and hemorrhagic transformation of the ischemic brain lesion. Using data from the Italian multicenter observational MAGIC (MArker bioloGici nell'Ictus Cerebrale) Study, we evaluated the effect of inflammatory and metalloproteinases profiles on three-month functional outcome, hemorrhagic transformation and mortality in 327 patients with AIS treated with intravenous thrombolys in according to SITS-MOST (Safe Implementation of Thrombolysis in Stroke-MOnitoring STudy) criteria. Circulating biomarkers were assessed at baseline and 24 h after thrombolysis. Read More

    Can we rely on out-of-hospital blood samples? A prospective interventional study on the pre-analytical stability of blood samples under prehospital emergency medicine conditions.
    Scand J Trauma Resusc Emerg Med 2017 Mar 4;25(1):24. Epub 2017 Mar 4.
    Department of Anaesthesiology, Erlangen University Hospital, Krankenhausstrasse 12, 91054, Erlangen, Germany.
    Background: Prehospital intravenous access provides the opportunity to sample blood from an emergency patient at the earliest possible moment in the course of acute illness and in a state prior to therapeutic interventions. Our study investigates the pre-analytical stability of biomarkers in prehospital emergency medicine and will answer the question whether an approach of blood sampling out in the field will deliver valid laboratory results.

    Methods: We prepared pairs of blood samples from healthy volunteers and volunteering patients post cardio-thoracic surgery. Read More

    Sex Differences in Inflammatory Markers and Health Status Among Young Adults With Acute Myocardial Infarction: Results From the VIRGO (Variation in Recovery: Role of Gender on Outcomes of Young Acute Myocardial Infarction Patients) Study.
    Circ Cardiovasc Qual Outcomes 2017 Feb 22;10(2):e003470. Epub 2017 Feb 22.
    From the Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, CT (Y.L., S.Z., R.P.D., E.S.S., H.M.K.); Section of Cardiovascular Medicine, Department of Internal Medicine (Y.L., S.Z., R.P.D., E.S.S., H.M.K.), Section of General Internal Medicine, Department of Internal Medicine (M.G., N.P.L.), Robert Wood Johnson Foundation Clinical Scholars Program, Department of Internal Medicine (H.M.K.), and Department of Emergency Medicine (R.P.D., G.D.), Yale School of Medicine, New Haven, CT; Department of Chronic Disease Epidemiology (J.H.L.) and Department of Health Policy and Management (H.M.K.), Yale School of Public Health, New Haven, CT; University of Missouri-Kansas City (J.A.S.); Saint Luke's Mid America Heart Institute, Kansas City, MO (J.A.S.); and Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (P.M.R.).
    Background: Young women (≤55 years of age) with acute myocardial infarction (AMI) have higher mortality risk than similarly aged men. Elevated inflammatory markers are associated with an increased risk of cardiovascular outcomes after AMI, but little is known about whether young women have higher inflammatory levels after AMI compared with young men.

    Methods And Results: We assessed sex differences in post-AMI inflammatory markers and whether such differences account for sex differences in 12-month health status, using data from 2219 adults with AMI, 18 to 55 years of age, in the United States. Read More

    Automated variable aortic control versus complete aortic occlusion in a swine model of hemorrhage.
    J Trauma Acute Care Surg 2017 Apr;82(4):694-703
    From the Clinical Investigation Facility (T.K.W., L.P.N., N.F.C., J.K.G.) and Heart, Lung and Vascular Center (T.K.W.), David Grant USAF Medical Center, Travis Air Force Base, California; Departments of Emergency Medicine (M.A.J.) and Surgery (R.M.R., A.J.D.), UC Davis Medical Center, Sacramento, California; Department of Surgery (S.-A.F.), Wright State University, Dayton, Ohio; and US Combat Casualty Care Research Program (T.E.R.), US Army Medical Research and Materiel Command, Fort Detrick, Maryland.
    Background: Future endovascular hemorrhage control devices will require features that mitigate the adverse effects of vessel occlusion. Permissive regional hypoperfusion (PRH) with variable aortic control (VAC) is a novel strategy to minimize hemorrhage and reduce the ischemic burden of complete aortic occlusion (AO). The objective of this study was to compare PRH with VAC to AO in a lethal model of hemorrhage. Read More

    Head injury serum markers for assessing response to trauma: Design of the HeadSMART study.
    Brain Inj 2017 31;31(3):370-378. Epub 2017 Jan 31.
    e University of Michigan Health System , Ann Arbor , MI , USA.
    Background: Accurate diagnosis and risk stratification of traumatic brain injury (TBI) at time of presentation remains a clinical challenge. The Head Injury Serum Markers for Assessing Response to Trauma study (HeadSMART) aims to examine blood-based biomarkers for diagnosing and determining prognosis in TBI.

    Methods: HeadSMART is a 6-month prospective cohort study comparing emergency department patients evaluated for TBI (exposure group) to (1) emergency department patients evaluated for traumatic injury without head trauma and (2) healthy persons. Read More

    Suspected ACS Patients Presenting With Myocardial Damage or a Type 2 Myocardial Infarction Have a Similar Late Mortality to Patients With a Type 1 Myocardial Infarction: A Report from the Australian and New Zealand 2012 SNAPSHOT ACS Study.
    Heart Lung Circ 2016 Dec 31. Epub 2016 Dec 31.
    Department of Cardiology, Liverpool Hospital, Sydney, NSW, Australia; South Western Sydney Clinical School, the University of New South Wales, Sydney, NSW, Australia. Electronic address:
    Background: Cardiac troponin (T and I) are considered the standard markers for detection of myocardial damage and the diagnosis of acute coronary syndrome (ACS) among patients who present to an emergency department with chest pain. However, these markers can be released in other situations and may be associated with short- and long-term clinical outcomes. In this study, we examine late mortality rates among patients presenting with a suspected ACS due to an unstable coronary plaque and those patients having a non-ACS. Read More

    Subclinical atherosclerosis risk markers in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis.
    Respir Med 2017 Feb 8;123:18-27. Epub 2016 Dec 8.
    Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. Electronic address:
    Background And Aims: Chronic obstructive pulmonary disease (COPD) is associated with increased cardiovascular morbidity and mortality. Identifying early changes of cardiovascular system before the occurrence of fatal clinical event is critical for the management of COPD. We performed a meta-analysis to investigate the associations between COPD and subclinical markers of cardiovascular risk. Read More

    Interpretation of positive troponin results among patients with and without myocardial infarction.
    Proc (Bayl Univ Med Cent) 2017 Jan;30(1):11-15
    Baylor Heart and Vascular Institute, Dallas, Texas (Tecson, McCullough); Baylor Scott & White Research Institute, Dallas, Texas (Tecson); Texas A&M Health Science Center College of Medicine, Dallas, Texas (Tecson, Schussler, McCullough); Department of Clinical Affairs, Alere Inc., San Diego, California (Arnold); Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee (Barrett); New York Methodist Hospital, Brooklyn, New York (Birkhahn); Division of Cardiovascular Medicine, University of California San Diego Health, La Jolla, California (Daniels); Inova Heart and Vascular Institute, Falls Church, Virginia (DeFilippi); Medical University of South Carolina, Charleston, South Carolina (Headden); Baylor University Ben Taub Hospital, Houston, Texas (Peacock); International Heart Institute of Montana, Missoula, Montana (Reed); Department of Emergency Medicine, Stony Brook University Hospital, Stony Brook, New York (Singer); Division of Cardiology, Baylor University Medical Center, Dallas, Texas (Schussler, McCullough); Baylor Jack and Jane Hamilton Heart and Vascular Hospital, Dallas, Texas (Schussler, McCullough); Hennepin County Medical Center Emergency Department, Minneapolis, Minnesota (Smith); Emergency Department, Christchurch Hospital, and University of Otago, Christchurch, New Zealand (Than); and The Heart Hospital Baylor Plano, Plano, Texas (McCullough).
    Measuring cardiac troponins is integral to diagnosing acute myocardial infarction (AMI); however, troponins may be elevated without AMI, and the use of multiple different assays confounds comparisons. We considered characteristics and serial troponin values in emergency department chest pain patients with and without AMI to interpret troponin excursions. We compared serial troponin in 124 AMI and non-AMI patients from the observational Performance of Triage Cardiac Markers in the Clinical Setting (PEARL) study who presented with chest pain and had at least one troponin value exceeding the 99th percentile of normal. Read More

    Characterization of mitochondrial injury after cardiac arrest (COMICA).
    Resuscitation 2017 Apr 23;113:56-62. Epub 2017 Jan 23.
    University of Pittsburgh School of Medicine, Pittsburgh, United States.
    Introduction: Mitochondrial injury post-cardiac arrest has been described in pre-clinical settings but the extent to which this injury occurs in humans remains largely unknown. We hypothesized that increased levels of mitochondrial biomarkers would be associated with mortality and neurological morbidity in post-cardiac arrest subjects.

    Methods: We performed a prospective multicenter study of post-cardiac arrest subjects. Read More

    Long-term mortality in older patients discharged after acute decompensated heart failure: a prospective cohort study.
    BMC Geriatr 2017 Jan 26;17(1):34. Epub 2017 Jan 26.
    Université Paris Est (UPEC), A-TVB DHU, IMRB, EA7376, CEpiA Clinical Epidemiology and Ageing unit, Créteil, France.
    Background: Data are available on short- and intermediate-term mortality rates after discharge for acutely decompensated heart failure (ADHF). However, few studies specifically addressed ADHF outcomes in patients aged 75 years or over, who contribute more than half of all ADHF admissions. Our objectives here were to estimate the long-term mortality of patients aged 75 years or over who were discharged after admission for ADHF and to identify factors, especially geriatric findings, independently associated with 2-year mortality. Read More

    The evaluation of a new marker of transmyocardial repolarization parameters in ischemic stroke patients; T peak-T end (T p-e), T p-e/QTc.
    Acta Neurol Belg 2017 Jun 21;117(2):461-467. Epub 2017 Jan 21.
    Department of Emergency Medicine, Keçiören Training and Research Hospital, Pınarbaşı, Sanatoryum Caddesi, Ardahan Sokak, No: 25, 06280, Keçiören, Ankara, Turkey.
    The cardiovascular manifestations of acute ischemic stroke have been well known. Several electrocardiography (ECG) abnormalities have been reported in patients following acute stroke, including QT interval prolongation, ST segment deviation and T-wave changes. This study aimed to investigate the changes in transmyocardial repolarization parameters, in ischemic stroke patients. Read More

    Predictive capacity of a multimarker strategy to determine short-term mortality in patients attending a hospital emergency Department for acute heart failure. BIO-EAHFE study.
    Clin Chim Acta 2017 Mar 6;466:22-30. Epub 2017 Jan 6.
    Área de Urgencias, Hospital Clinic, Barcelona, Grupo de Investigación "Urgencias: procesos y patologías", IDIBAPS, Barcelona, Spain.
    Objective: A multimarker strategy may help determine the prognosis of patients with acute heart failure (AHF). The aim of this study was to evaluate the capacity of mid-regional pro-adrenomedullin (MRproADM), copeptin and interleukin-6 (IL-6) combined with conventional clinical and biochemical markers to predict the 30-day mortality of patients with AHF.

    Methods: We performed an observational, multicenter, prospective study of patients attended in the emergency department (ED) for AHF. Read More

    Rule-In and Rule-Out of Myocardial Infarction Using Cardiac Troponin and Glycemic Biomarkers in Patients with Symptoms Suggestive of Acute Coronary Syndrome.
    Clin Chem 2017 Jan 10;63(1):403-414. Epub 2016 Nov 10.
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada;
    Background: Early rule-in/rule-out of myocardial infarction (MI) in patients presenting to the emergency department (ED) is important for patient care and resource allocation. Given that dysglycemia is a strong risk factor for MI, we sought to explore and compare different combinations of cardiac troponin (cTn) cutoffs with glycemic markers for the early rule-in/rule-out of MI.

    Methods: We included ED patients (n = 1137) with symptoms suggestive of acute coronary syndrome (ACS) who had cTnI, high-sensitivity cTnI (hs-cTnI), hs-cTnT, glucose, and hemoglobin A1c (Hb A1c) measurements. Read More

    Early Administration of Glutamine Protects Cardiomyocytes from Post-Cardiac Arrest Acidosis.
    Biomed Res Int 2016 12;2016:2106342. Epub 2016 Dec 12.
    Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan.
    Postcardiac arrest acidosis can decrease survival. Effective medications without adverse side effects are still not well characterized. We aimed to analyze whether early administration of glutamine could improve survival and protect cardiomyocytes from postcardiac arrest acidosis using animal and cell models. Read More

    Preoperative Renal Resistive Index Predicts Risk of Acute Kidney Injury in Patients Undergoing Cardiac Surgery.
    J Cardiothorac Vasc Anesth 2016 Oct 11. Epub 2016 Oct 11.
    Department of Medicine, Karolinska Institutet, Solna, Sweden; Department of Emergency Medicine, Karolinska University Hospital, Stockholm, Sweden.
    Objective: To investigate whether an elevated preoperative renal resistive index (RRI) predicts acute kidney injury (AKI) in patients undergoing cardiac surgery.

    Design: Prospective cohort study.

    Setting: University hospital. Read More

    Decreased high-density lipoprotein cholesterol level is an early prognostic marker for organ dysfunction and death in patients with suspected sepsis.
    J Crit Care 2017 Apr 7;38:289-294. Epub 2016 Dec 7.
    Centre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada.
    Purpose: We sought to determine whether an early high-density lipoprotein cholesterol (HDL-C) measurement at emergency department (ED) admission is prognostic of multiorgan dysfunction syndrome (MODS) and death in a suspected sepsis cohort.

    Materials And Methods: Two hundred patients with clinically suspected sepsis were recruited at admission to our tertiary care hospital's ED. Lipids were measured at the time of first ED blood draw. Read More

    Prophylactic versus selective blood transfusion for sickle cell disease in pregnancy.
    Cochrane Database Syst Rev 2016 12 22;12:CD010378. Epub 2016 Dec 22.
    UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Department of Reproductive Health and Research, World Health Organization, Avenue Appia 20, Geneva, Switzerland, CH-1211.
    Background: Pregnant women with sickle cell disease (HbSS, HbSC and HbSβThal) may require blood transfusion to prevent severe anaemia or to manage potential medical complications. Preventive blood transfusion in the absence of complications starting from the early weeks of pregnancy or blood transfusion only for medical or obstetric indications have been used as management policies. There is currently no consensus on the blood transfusion policy that guarantees optimal clinical benefits with minimal risks for such women and their babies. Read More

    Biophysical, Molecular, and Pharmacological Characterization of Voltage-Dependent Sodium Channels From Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
    Can J Cardiol 2017 Feb 11;33(2):269-278. Epub 2016 Oct 11.
    Centre de recherche de l'Institut universitaire en santé mentale de Québec, Québec City, Québec, Canada; Department of Medicine, Université Laval, Quebec City, Quebec, Canada. Electronic address:
    Background: The ability to differentiate patient-specific human induced pluripotent stem cells in cardiac myocytes (hiPSC-CM) offers novel perspectives for cardiovascular research. A number of studies, that reported mainly on current-voltage curves used hiPSC-CM to model voltage-gated Na(+) channel (Nav) dysfunction. However, the expression patterns and precise biophysical and pharmacological properties of Nav channels from hiPSC-CM remain unknown. Read More

    Association of brain metabolites with blood lactate and glucose levels with respect to neurological outcomes after out-of-hospital cardiac arrest: a preliminary microdialysis study.
    Resuscitation 2016 Oct 27. Epub 2016 Oct 27.
    Emergency Medical Center, Kagawa University Hospital, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan.
    Aim: Out-of-hospital cardiac arrest (OHCA) is associated with poor prognosis. Cerebral microdialysis (CMD) is an efficient sampling technique to detect neurochemical changes in brain interstitial tissue. In this retrospective study, we hypothesised that there are different CMD levels between patients with favourable and unfavourable neurological outcomes. Read More

    Association of brain metabolites with blood lactate and glucose levels with respect to neurological outcomes after out-of-hospital cardiac arrest: A preliminary microdialysis study.
    Resuscitation 2017 Jan 27;110:26-31. Epub 2016 Oct 27.
    Emergency Medical Center, Kagawa University Hospital, 1750-1 Ikenobe, Kita, Miki, Kagawa 761-0793, Japan.
    Aim: Out-of-hospital cardiac arrest (OHCA) is associated with poor prognosis. Cerebral microdialysis (CMD) is an efficient sampling technique to detect neurochemical changes in brain interstitial tissue. In this retrospective study, we hypothesised that there are different CMD levels between patients with favourable and unfavourable neurological outcomes. Read More

    Biological and psychological predictors of posttraumatic stress disorder onset and chronicity. A one-year prospective study.
    Neurobiol Stress 2016 Jun 4;3:61-67. Epub 2016 Feb 4.
    Inserm, U1061, Montpellier, F-34093, France; Université Montpellier, Montpellier, F-34000, France.
    Background: Few studies have prospectively examined risk factors for posttraumatic stress disorder (PTSD) in the aftermath of a traumatic exposure. The aim of this study is to identify the concurrent influence of psychological and biological diatheses on PTSD onset and maintenance, taking into account socio-demographic factors and psychiatric antecedents.

    Methods: A total of 123 civilians (61. Read More

    Association between neutrophilic granulocyte percentage and depression in hospitalized patients with heart failure.
    BMC Psychiatry 2016 Dec 13;16(1):446. Epub 2016 Dec 13.
    First Department of Cardiology, People's Hospital of Shaanxi Province, Xi'an, 710068, Shaanxi, People's Republic of China.
    Background: Previous researches reveal that depression is associated with increased inflammatory markers. As a simple and cheap inflammatory marker, we hypothesize that neutrophilic granulocyte percentage is associated with depression in hospitalized heart failure patients, whose prevalence of depression is at a very high level.

    Methods: Three hundred sixty-six cases of hospitalized heart failure patients with left ventricular ejection fraction (LVEF) ≤45% and New York Heart Association (NYHA) class II-IV were enrolled. Read More

    Heart-type Fatty Acid Binding Protein in the Assessment of Acute Pulmonary Embolism.
    Am J Med Sci 2016 Dec 30;352(6):557-562. Epub 2016 Aug 30.
    15th Ward, Department of Cardiology, Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Capital Medical University, Beijing, PR China.
    Objective: To explore the predictive value of heart-type fatty acid binding protein (H-FABP) in the stratification and prognosis of patients with acute pulmonary embolism (APE).

    Methods: According to risk stratification, 69 patients with APE admitted into the emergency department within 24 hours after onset were divided into the following 3 groups: high-risk group, moderate-risk group and low-risk group. H-FABP- and cardiac troponin I (cTNI)-positive rates of all groups were analyzed and compared, and the correlation between major adverse events (death, endotracheal intubation and cardiopulmonary resuscitation) and the cardiac markers (heart rate, arterial partial pressure of oxygen, right ventricular dimension, pulmonary arterial pressure, etc. Read More

    Cardiac complications associated with the influenza viruses A subtype H7N9 or pandemic H1N1 in critically ill patients under intensive care.
    Braz J Infect Dis 2017 Jan - Feb;21(1):12-18. Epub 2016 Nov 29.
    The First Affiliated Hospital of Soochow University, Department of Medicine, Respiratory, Emergency and Critical Care Medicine, Suzhou, China. Electronic address:
    Background And Objective: The clinical presentations and disease courses of patients hospitalized with either influenza A virus subtype H7N9 (H7N9) or 2009 pandemic H1N1 influenza virus were compared in a recent report, but associated cardiac complications remain unclear. The present retrospective study investigated whether cardiac complications in critically ill patients with H7N9 infections differed from those infected with the pandemic H1N1 influenza virus strain.

    Methods: Suspect cases were confirmed by reverse transcription polymerase chain reaction assays with specific confirmation of the pandemic H1N1 strain at the Centers for Disease Control and Prevention. Read More

    A case of primary intracardiac yolk sac tumour with extracardiac extension.
    J Surg Case Rep 2016 Nov 24;2016(11). Epub 2016 Nov 24.
    Department of Pathology, Lakeshore Hospital and Research Centre, Kochi, India.
    Primary cardiac tumour is a rare entity as secondaries in the heart are more common. A 2-year-old child was having repeated respiratory tract infection with poor oral intake and poor activity for 3 months. His symptoms progressed from New York Heart Association (NYHA) Class II to IV. Read More

    Biomarkers of cardiovascular injury and stress are associated with increased frequency of ventricular ectopy: a population-based study.
    BMC Cardiovasc Disord 2016 Nov 22;16(1):233. Epub 2016 Nov 22.
    Division of Medicine, Akershus University Hospital, Lørenskog, Norway.
    Background: Asymptomatic ventricular arrhythmias are common and associated with increased risk of cardiovascular mortality. Cardiac troponins, natriuretic peptides and C-reactive protein (CRP) are also predictive of adverse cardiovascular events in the general population, but limited information is available on the relationship between these biomarkers and ventricular ectopy in a community-based population. The objectives were to evaluate the associations between ventricular ectopic activity and N-terminal pro-B-type natriuretic peptide (NT-proBNP), high sensitivity-troponin I (hs-TnI) and hs-CRP in a community-based setting. Read More

    Clinical Outcomes of Vasospastic Angina Patients Presenting With Acute Coronary Syndrome.
    J Am Heart Assoc 2016 Nov 16;5(11). Epub 2016 Nov 16.
    Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Background: Coronary vasospasm is an important pathogenesis of acute coronary syndrome (ACS). However, the clinical features and prognosis of vasospastic angina (VA) patients presenting with ACS (VAACS) are still unclear. We aimed to evaluate the clinical characteristics and long-term outcomes of VAACS patients without significant coronary artery stenosis. Read More

    Neuro-Psychological Pattern in Patients Suffering from Primitive Dilated Cardiomyopathy with Impairment in Executive Function.
    Curr Neurovasc Res 2017 ;14(1):39-45
    Emergency and Organ Transplant Department, Cardiology Unit, University of Bari, Piazza Giulio Cesare, 11; 70124, Bari, Italy.
    According to the American Heart Association (AHA), primitive dilated cardiomyopathy (PDCM) is a "progressive dilation of the left or both ventricles and a depressed contractility in the absence of abnormal load conditions". It evolves in progressive heart-failure. The term "cardiogenic dementia" expresses the intimate connection between heart diseases and cognitive functions. Read More

    Role of alpha- and beta-adrenergic receptors in cardiomyocyte differentiation from murine-induced pluripotent stem cells.
    Cell Prolif 2017 Feb 27;50(1). Epub 2016 Oct 27.
    Department of Cardiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China.
    Objectives: Induced pluripotent stem cell (iPSC)-derived cardiomyocytes are a promising source of cells for regenerative heart disease therapies, but progress towards their use has been limited by their low differentiation efficiency and high cellular heterogeneity. Previous studies have demonstrated expression of adrenergic receptors (ARs) in stem cells after differentiation; however, roles of ARs in fate specification of stem cells, particularly in cardiomyocyte differentiation and development, have not been characterized.

    Materials And Methods: Murine-induced pluripotent stem cells (miPSCs) were cultured in hanging drops to form embryoid bodies, cells of which were then differentiated into cardiomyocytes. Read More

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