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    726 results match your criteria Use of Cardiac Markers in the Emergency Department

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    Head injury serum markers for assessing response to trauma: Design of the HeadSMART study.
    Brain Inj 2017 Jan 31:1-9. Epub 2017 Jan 31.
    e University of Michigan Health System, Ann Arbor , MI , USA.
    Background: Accurate diagnosis and risk stratification of traumatic brain injury (TBI) at time of presentation remains a clinical challenge. The Head Injury Serum Markers for Assessing Response to Trauma study (HeadSMART) aims to examine blood-based biomarkers for diagnosing and determining prognosis in TBI.

    Methods: HeadSMART is a 6-month prospective cohort study comparing emergency department patients evaluated for TBI (exposure group) to (1) emergency department patients evaluated for traumatic injury without head trauma and (2) healthy persons. Read More

    Suspected ACS Patients Presenting With Myocardial Damage or a Type 2 Myocardial Infarction Have a Similar Late Mortality to Patients With a Type 1 Myocardial Infarction: A Report from the Australian and New Zealand 2012 SNAPSHOT ACS Study.
    Heart Lung Circ 2016 Dec 31. Epub 2016 Dec 31.
    Department of Cardiology, Liverpool Hospital, Sydney, NSW, Australia; South Western Sydney Clinical School, the University of New South Wales, Sydney, NSW, Australia. Electronic address:
    Background: Cardiac troponin (T and I) are considered the standard markers for detection of myocardial damage and the diagnosis of acute coronary syndrome (ACS) among patients who present to an emergency department with chest pain. However, these markers can be released in other situations and may be associated with short- and long-term clinical outcomes. In this study, we examine late mortality rates among patients presenting with a suspected ACS due to an unstable coronary plaque and those patients having a non-ACS. Read More

    Subclinical atherosclerosis risk markers in patients with chronic obstructive pulmonary disease: A systematic review and meta-analysis.
    Respir Med 2017 Feb 8;123:18-27. Epub 2016 Dec 8.
    Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China. Electronic address:
    Background And Aims: Chronic obstructive pulmonary disease (COPD) is associated with increased cardiovascular morbidity and mortality. Identifying early changes of cardiovascular system before the occurrence of fatal clinical event is critical for the management of COPD. We performed a meta-analysis to investigate the associations between COPD and subclinical markers of cardiovascular risk. Read More

    Interpretation of positive troponin results among patients with and without myocardial infarction.
    Proc (Bayl Univ Med Cent) 2017 Jan;30(1):11-15
    Baylor Heart and Vascular Institute, Dallas, Texas (Tecson, McCullough); Baylor Scott & White Research Institute, Dallas, Texas (Tecson); Texas A&M Health Science Center College of Medicine, Dallas, Texas (Tecson, Schussler, McCullough); Department of Clinical Affairs, Alere Inc., San Diego, California (Arnold); Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee (Barrett); New York Methodist Hospital, Brooklyn, New York (Birkhahn); Division of Cardiovascular Medicine, University of California San Diego Health, La Jolla, California (Daniels); Inova Heart and Vascular Institute, Falls Church, Virginia (DeFilippi); Medical University of South Carolina, Charleston, South Carolina (Headden); Baylor University Ben Taub Hospital, Houston, Texas (Peacock); International Heart Institute of Montana, Missoula, Montana (Reed); Department of Emergency Medicine, Stony Brook University Hospital, Stony Brook, New York (Singer); Division of Cardiology, Baylor University Medical Center, Dallas, Texas (Schussler, McCullough); Baylor Jack and Jane Hamilton Heart and Vascular Hospital, Dallas, Texas (Schussler, McCullough); Hennepin County Medical Center Emergency Department, Minneapolis, Minnesota (Smith); Emergency Department, Christchurch Hospital, and University of Otago, Christchurch, New Zealand (Than); and The Heart Hospital Baylor Plano, Plano, Texas (McCullough).
    Measuring cardiac troponins is integral to diagnosing acute myocardial infarction (AMI); however, troponins may be elevated without AMI, and the use of multiple different assays confounds comparisons. We considered characteristics and serial troponin values in emergency department chest pain patients with and without AMI to interpret troponin excursions. We compared serial troponin in 124 AMI and non-AMI patients from the observational Performance of Triage Cardiac Markers in the Clinical Setting (PEARL) study who presented with chest pain and had at least one troponin value exceeding the 99th percentile of normal. Read More

    Characterization of mitochondrial injury after cardiac arrest (COMICA).
    Resuscitation 2017 Jan 23;113:56-62. Epub 2017 Jan 23.
    University of Pittsburgh School of Medicine, Pittsburgh, United States.
    Introduction: Mitochondrial injury post-cardiac arrest has been described in pre-clinical settings but the extent to which this injury occurs in humans remains largely unknown. We hypothesized that increased levels of mitochondrial biomarkers would be associated with mortality and neurological morbidity in post-cardiac arrest subjects.

    Methods: We performed a prospective multicenter study of post-cardiac arrest subjects. Read More

    Long-term mortality in older patients discharged after acute decompensated heart failure: a prospective cohort study.
    BMC Geriatr 2017 Jan 26;17(1):34. Epub 2017 Jan 26.
    Université Paris Est (UPEC), A-TVB DHU, IMRB, EA7376, CEpiA Clinical Epidemiology and Ageing unit, Créteil, France.
    Background: Data are available on short- and intermediate-term mortality rates after discharge for acutely decompensated heart failure (ADHF). However, few studies specifically addressed ADHF outcomes in patients aged 75 years or over, who contribute more than half of all ADHF admissions. Our objectives here were to estimate the long-term mortality of patients aged 75 years or over who were discharged after admission for ADHF and to identify factors, especially geriatric findings, independently associated with 2-year mortality. Read More

    The evaluation of a new marker of transmyocardial repolarization parameters in ischemic stroke patients; T peak-T end (T p-e), T p-e/QTc.
    Acta Neurol Belg 2017 Jan 21. Epub 2017 Jan 21.
    Department of Emergency Medicine, Keçiören Training and Research Hospital, Pınarbaşı, Sanatoryum Caddesi, Ardahan Sokak, No: 25, 06280, Keçiören, Ankara, Turkey.
    The cardiovascular manifestations of acute ischemic stroke have been well known. Several electrocardiography (ECG) abnormalities have been reported in patients following acute stroke, including QT interval prolongation, ST segment deviation and T-wave changes. This study aimed to investigate the changes in transmyocardial repolarization parameters, in ischemic stroke patients. Read More

    Predictive capacity of a multimarker strategy to determine short-term mortality in patients attending a hospital emergency Department for acute heart failure. BIO-EAHFE study.
    Clin Chim Acta 2017 Mar 6;466:22-30. Epub 2017 Jan 6.
    Área de Urgencias, Hospital Clinic, Barcelona, Grupo de Investigación "Urgencias: procesos y patologías", IDIBAPS, Barcelona, Spain.
    Objective: A multimarker strategy may help determine the prognosis of patients with acute heart failure (AHF). The aim of this study was to evaluate the capacity of mid-regional pro-adrenomedullin (MRproADM), copeptin and interleukin-6 (IL-6) combined with conventional clinical and biochemical markers to predict the 30-day mortality of patients with AHF.

    Methods: We performed an observational, multicenter, prospective study of patients attended in the emergency department (ED) for AHF. Read More

    Rule-In and Rule-Out of Myocardial Infarction Using Cardiac Troponin and Glycemic Biomarkers in Patients with Symptoms Suggestive of Acute Coronary Syndrome.
    Clin Chem 2017 Jan 10;63(1):403-414. Epub 2016 Nov 10.
    Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada;
    Background: Early rule-in/rule-out of myocardial infarction (MI) in patients presenting to the emergency department (ED) is important for patient care and resource allocation. Given that dysglycemia is a strong risk factor for MI, we sought to explore and compare different combinations of cardiac troponin (cTn) cutoffs with glycemic markers for the early rule-in/rule-out of MI.

    Methods: We included ED patients (n = 1137) with symptoms suggestive of acute coronary syndrome (ACS) who had cTnI, high-sensitivity cTnI (hs-cTnI), hs-cTnT, glucose, and hemoglobin A1c (Hb A1c) measurements. Read More

    Early Administration of Glutamine Protects Cardiomyocytes from Post-Cardiac Arrest Acidosis.
    Biomed Res Int 2016 12;2016:2106342. Epub 2016 Dec 12.
    Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan.
    Postcardiac arrest acidosis can decrease survival. Effective medications without adverse side effects are still not well characterized. We aimed to analyze whether early administration of glutamine could improve survival and protect cardiomyocytes from postcardiac arrest acidosis using animal and cell models. Read More

    Preoperative Renal Resistive Index Predicts Risk of Acute Kidney Injury in Patients Undergoing Cardiac Surgery.
    J Cardiothorac Vasc Anesth 2016 Oct 11. Epub 2016 Oct 11.
    Department of Medicine, Karolinska Institutet, Solna, Sweden; Department of Emergency Medicine, Karolinska University Hospital, Stockholm, Sweden.
    Objective: To investigate whether an elevated preoperative renal resistive index (RRI) predicts acute kidney injury (AKI) in patients undergoing cardiac surgery.

    Design: Prospective cohort study.

    Setting: University hospital. Read More

    Decreased high-density lipoprotein cholesterol level is an early prognostic marker for organ dysfunction and death in patients with suspected sepsis.
    J Crit Care 2016 Dec 7;38:289-294. Epub 2016 Dec 7.
    Centre for Heart Lung Innovation, University of British Columbia, Vancouver, British Columbia, Canada.
    Purpose: We sought to determine whether an early high-density lipoprotein cholesterol (HDL-C) measurement at emergency department (ED) admission is prognostic of multiorgan dysfunction syndrome (MODS) and death in a suspected sepsis cohort.

    Materials And Methods: Two hundred patients with clinically suspected sepsis were recruited at admission to our tertiary care hospital's ED. Lipids were measured at the time of first ED blood draw. Read More

    Prophylactic versus selective blood transfusion for sickle cell disease in pregnancy.
    Cochrane Database Syst Rev 2016 12 22;12:CD010378. Epub 2016 Dec 22.
    UNDP/UNFPA/UNICEF/WHO/World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Department of Reproductive Health and Research, World Health Organization, Avenue Appia 20, Geneva, Switzerland, CH-1211.
    Background: Pregnant women with sickle cell disease (HbSS, HbSC and HbSβThal) may require blood transfusion to prevent severe anaemia or to manage potential medical complications. Preventive blood transfusion in the absence of complications starting from the early weeks of pregnancy or blood transfusion only for medical or obstetric indications have been used as management policies. There is currently no consensus on the blood transfusion policy that guarantees optimal clinical benefits with minimal risks for such women and their babies. Read More

    Biophysical, Molecular, and Pharmacological Characterization of Voltage-Dependent Sodium Channels From Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
    Can J Cardiol 2017 Feb 11;33(2):269-278. Epub 2016 Oct 11.
    Centre de recherche de l'Institut universitaire en santé mentale de Québec, Québec City, Québec, Canada; Department of Medicine, Université Laval, Quebec City, Quebec, Canada. Electronic address:
    Background: The ability to differentiate patient-specific human induced pluripotent stem cells in cardiac myocytes (hiPSC-CM) offers novel perspectives for cardiovascular research. A number of studies, that reported mainly on current-voltage curves used hiPSC-CM to model voltage-gated Na(+) channel (Nav) dysfunction. However, the expression patterns and precise biophysical and pharmacological properties of Nav channels from hiPSC-CM remain unknown. Read More

    Association of brain metabolites with blood lactate and glucose levels with respect to neurological outcomes after out-of-hospital cardiac arrest: a preliminary microdialysis study.
    Resuscitation 2016 Oct 27. Epub 2016 Oct 27.
    Emergency Medical Center, Kagawa University Hospital, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan.
    Aim: Out-of-hospital cardiac arrest (OHCA) is associated with poor prognosis. Cerebral microdialysis (CMD) is an efficient sampling technique to detect neurochemical changes in brain interstitial tissue. In this retrospective study, we hypothesised that there are different CMD levels between patients with favourable and unfavourable neurological outcomes. Read More

    Association of brain metabolites with blood lactate and glucose levels with respect to neurological outcomes after out-of-hospital cardiac arrest: A preliminary microdialysis study.
    Resuscitation 2017 Jan 27;110:26-31. Epub 2016 Oct 27.
    Emergency Medical Center, Kagawa University Hospital, 1750-1 Ikenobe, Kita, Miki, Kagawa 761-0793, Japan.
    Aim: Out-of-hospital cardiac arrest (OHCA) is associated with poor prognosis. Cerebral microdialysis (CMD) is an efficient sampling technique to detect neurochemical changes in brain interstitial tissue. In this retrospective study, we hypothesised that there are different CMD levels between patients with favourable and unfavourable neurological outcomes. Read More

    Biological and psychological predictors of posttraumatic stress disorder onset and chronicity. A one-year prospective study.
    Neurobiol Stress 2016 Jun 4;3:61-67. Epub 2016 Feb 4.
    Inserm, U1061, Montpellier, F-34093, France; Université Montpellier, Montpellier, F-34000, France.
    Background: Few studies have prospectively examined risk factors for posttraumatic stress disorder (PTSD) in the aftermath of a traumatic exposure. The aim of this study is to identify the concurrent influence of psychological and biological diatheses on PTSD onset and maintenance, taking into account socio-demographic factors and psychiatric antecedents.

    Methods: A total of 123 civilians (61. Read More

    Association between neutrophilic granulocyte percentage and depression in hospitalized patients with heart failure.
    BMC Psychiatry 2016 Dec 13;16(1):446. Epub 2016 Dec 13.
    First Department of Cardiology, People's Hospital of Shaanxi Province, Xi'an, 710068, Shaanxi, People's Republic of China.
    Background: Previous researches reveal that depression is associated with increased inflammatory markers. As a simple and cheap inflammatory marker, we hypothesize that neutrophilic granulocyte percentage is associated with depression in hospitalized heart failure patients, whose prevalence of depression is at a very high level.

    Methods: Three hundred sixty-six cases of hospitalized heart failure patients with left ventricular ejection fraction (LVEF) ≤45% and New York Heart Association (NYHA) class II-IV were enrolled. Read More

    Heart-type Fatty Acid Binding Protein in the Assessment of Acute Pulmonary Embolism.
    Am J Med Sci 2016 Dec 30;352(6):557-562. Epub 2016 Aug 30.
    15th Ward, Department of Cardiology, Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Capital Medical University, Beijing, PR China.
    Objective: To explore the predictive value of heart-type fatty acid binding protein (H-FABP) in the stratification and prognosis of patients with acute pulmonary embolism (APE).

    Methods: According to risk stratification, 69 patients with APE admitted into the emergency department within 24 hours after onset were divided into the following 3 groups: high-risk group, moderate-risk group and low-risk group. H-FABP- and cardiac troponin I (cTNI)-positive rates of all groups were analyzed and compared, and the correlation between major adverse events (death, endotracheal intubation and cardiopulmonary resuscitation) and the cardiac markers (heart rate, arterial partial pressure of oxygen, right ventricular dimension, pulmonary arterial pressure, etc. Read More

    Cardiac complications associated with the influenza viruses A subtype H7N9 or pandemic H1N1 in critically ill patients under intensive care.
    Braz J Infect Dis 2017 Jan - Feb;21(1):12-18. Epub 2016 Nov 29.
    The First Affiliated Hospital of Soochow University, Department of Medicine, Respiratory, Emergency and Critical Care Medicine, Suzhou, China. Electronic address:
    Background And Objective: The clinical presentations and disease courses of patients hospitalized with either influenza A virus subtype H7N9 (H7N9) or 2009 pandemic H1N1 influenza virus were compared in a recent report, but associated cardiac complications remain unclear. The present retrospective study investigated whether cardiac complications in critically ill patients with H7N9 infections differed from those infected with the pandemic H1N1 influenza virus strain.

    Methods: Suspect cases were confirmed by reverse transcription polymerase chain reaction assays with specific confirmation of the pandemic H1N1 strain at the Centers for Disease Control and Prevention. Read More

    A case of primary intracardiac yolk sac tumour with extracardiac extension.
    J Surg Case Rep 2016 Nov 24;2016(11). Epub 2016 Nov 24.
    Department of Pathology, Lakeshore Hospital and Research Centre, Kochi, India.
    Primary cardiac tumour is a rare entity as secondaries in the heart are more common. A 2-year-old child was having repeated respiratory tract infection with poor oral intake and poor activity for 3 months. His symptoms progressed from New York Heart Association (NYHA) Class II to IV. Read More

    Biomarkers of cardiovascular injury and stress are associated with increased frequency of ventricular ectopy: a population-based study.
    BMC Cardiovasc Disord 2016 Nov 22;16(1):233. Epub 2016 Nov 22.
    Division of Medicine, Akershus University Hospital, Lørenskog, Norway.
    Background: Asymptomatic ventricular arrhythmias are common and associated with increased risk of cardiovascular mortality. Cardiac troponins, natriuretic peptides and C-reactive protein (CRP) are also predictive of adverse cardiovascular events in the general population, but limited information is available on the relationship between these biomarkers and ventricular ectopy in a community-based population. The objectives were to evaluate the associations between ventricular ectopic activity and N-terminal pro-B-type natriuretic peptide (NT-proBNP), high sensitivity-troponin I (hs-TnI) and hs-CRP in a community-based setting. Read More

    Clinical Outcomes of Vasospastic Angina Patients Presenting With Acute Coronary Syndrome.
    J Am Heart Assoc 2016 Nov 16;5(11). Epub 2016 Nov 16.
    Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
    Background: Coronary vasospasm is an important pathogenesis of acute coronary syndrome (ACS). However, the clinical features and prognosis of vasospastic angina (VA) patients presenting with ACS (VAACS) are still unclear. We aimed to evaluate the clinical characteristics and long-term outcomes of VAACS patients without significant coronary artery stenosis. Read More

    Neuro-psychological pattern in patients suffering from Primitive Dilated Cardiomyopathy with Impairment in Executive Function.
    Curr Neurovasc Res 2016 Nov 6. Epub 2016 Nov 6.
    Emergency and Organ Transplant Department, Cardiology Unit, University of Bari, Bari, Italy.
    According to the American Heart Association (AHA) , primitive dilated cardiomyopathy (PDCM) is a "progressive dilation of the left or both ventricles and a depressed contractility in absence of abnormal load conditions ". It evolves in progressive heart-failure. The term "cardiogenic dementia" expresses the intimate connection between heart diseases and cognitive functions. Read More

    Role of alpha- and beta-adrenergic receptors in cardiomyocyte differentiation from murine-induced pluripotent stem cells.
    Cell Prolif 2017 Feb 27;50(1). Epub 2016 Oct 27.
    Department of Cardiology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, China.
    Objectives: Induced pluripotent stem cell (iPSC)-derived cardiomyocytes are a promising source of cells for regenerative heart disease therapies, but progress towards their use has been limited by their low differentiation efficiency and high cellular heterogeneity. Previous studies have demonstrated expression of adrenergic receptors (ARs) in stem cells after differentiation; however, roles of ARs in fate specification of stem cells, particularly in cardiomyocyte differentiation and development, have not been characterized.

    Materials And Methods: Murine-induced pluripotent stem cells (miPSCs) were cultured in hanging drops to form embryoid bodies, cells of which were then differentiated into cardiomyocytes. Read More

    Acute Right Heart Failure in a Patient with Right Heart Thrombus and Pulmonary Thromboembolism.
    J Clin Diagn Res 2016 Sep 1;10(9):OD03-OD04. Epub 2016 Sep 1.
    Associate Professor, Department of Cardiology, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences , Tehran, Iran .
    Right Heart Thrombus (RiHT) management is really controversial, and appropriate guidelines are not present for the management. In patients referring with RiHT and Pulmonary Embolism (PE), there are three ways of managing these patients. Out of the three, one is thrombectomy, which is with high risk taking in mind the comorbidities these patients have. Read More

    Observed long-term mortality after 18,000 person-years among survivors in a large regional drowning registry.
    Resuscitation 2017 Jan 24;110:18-25. Epub 2016 Oct 24.
    Division of Pediatric Emergency Medicine, Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, United States.
    Aim: Long-term outcomes beyond one year after non-fatal drowning are uncharacterized. We estimated long-term mortality and identified prognostic factors in a large, population-based cohort.

    Methods: Population-based prospective cohort study (1974-1996) of Western Washington Drowning Registry (WWDR) subjects surviving the index drowning through hospital discharge. Read More

    Prevalence of Incomplete Functional and Symptomatic Recovery among Patients with Head Injury but Brain Injury Debatable.
    J Neurotrauma 2016 Dec 20. Epub 2016 Dec 20.
    9 Department of Physical Medicine & Rehabilitation, The Johns Hopkins University School of Medicine , Baltimore, Maryland.
    Head injury patients not meeting the American Congress of Rehabilitation Medicine (ACRM)'s criteria for mild traumatic brain injury (mTBI), referred to hereafter as HIBRID (Head Injury BRain Injury Debatable), are often excluded from studies. The prognostic importance of HIBRID is unclear. We investigated the differences in functional and symptomatic recovery at 1 month post-injury among TBI patients classified as: HIBRID, ACRM+ cranial computed tomography (CT)-, and cranial CT+; and trauma and healthy controls. Read More

    FACTORS ASSOCIATED WITH DEPRESSIVE EPISODE IN PATIENTS HOSPITALIZED WITH ACUTE CORONARY EVENTS.
    Georgian Med News 2016 Sep(258):23-27
    Department of Internal Medicine №3,Tbilisi State Medical University, Emergency Cardiology Center, Tbilisi Georgia.
    Severe infarction or its consequences are considered as triggering factors of incidental depression. The aim of our study was to reveal factors associated with depressive episode in patients hospitalized with acute coronary syndrome (acute myocardial infarction, unstable angina). The Beck Depression inventory (BDI) was used for assessment of depressive symptoms in patients with coronary disease in Emergency Cardiology Clinic Tbilisi, Georgia. Read More

    Prognostic Value of Right Ventricular Dysfunction Markers for Serious Adverse Events in Acute Normotensive Pulmonary Embolism.
    J Emerg Med 2017 Feb 15;52(2):137-150. Epub 2016 Oct 15.
    Carolinas Medical Center, Charlotte, North Carolina.
    Background: Right ventricular dysfunction (RVD) in pulmonary embolism (PE) has been associated with increased morbidity. Tools for RVD identification are not well defined. The prognostic value of RVD markers to predict serious adverse events (SAE) during hospitalization is unclear. Read More

    Noninvasive Testing in Emergency Department Patients with Low-Risk Chest Pain: Does the Evidence Support Current Guidelines?
    Cardiol Rev 2016 Nov/Dec;24(6):268-272
    From the *Division of Cardiology, Heart and Vascular Institute, †Department of Public Health Sciences, Hershey, PA, and ‡Department of Medicine, Penn State Hershey Medical Center, Hershey, PA.
    Patients who present to the emergency department with chest pain but no evidence of ischemia on the electrocardiogram and negative cardiac markers are at very low risk. The newest American Heart Association/American College of Cardiology guidelines give noninvasive cardiac testing a IIa recommendation in this patient population. Here, we will review the existing literature that was cited in the American Heart Association/American College of Cardiology document, as well as several large, contemporary, comparative observational studies which were not included to address the following question: Do the benefits of noninvasive cardiac testing in this patient population outweigh the risks? Read More

    A Plaque Disruption Index Identifies Patients with Non-STE-Type 1 Myocardial Infarction within 24 Hours of Troponin Positivity.
    PLoS One 2016 6;11(10):e0164315. Epub 2016 Oct 6.
    Department of Medicine, Division of Cardiology, St. Paul's Hospital and the University of British Columbia, Vancouver, BC, Canada.
    Background: Markers of plaque destabilization and disruption may have a role in identifying non-STE- type 1 Myocardial Infarction in patients presenting with troponin elevation. We hypothesized that a plaque disruption index (PDI) derived from multiple biomarkers and measured within 24 hours from the first detectable troponin in patients with acute non-STE- type 1 MI (NSTEMI-A) will confirm the diagnosis and identify these patients with higher specificity when compared to individual markers and coronary angiography.

    Methods: We examined 4 biomarkers of plaque destabilization and disruption: myeloperoxidase (MPO), high-sensitivity interleukin-6, myeloid-related protein 8/14 (MRP8/14) and pregnancy-associated plasma protein-A (PAPP-A) in 83 consecutive patients in 4 groups: stable non-obstructive coronary artery disease (CAD), stable obstructive CAD, NSTEMI-A (enrolled within 24 hours of troponin positivity), and NSTEMI-L (Late presentation NSTEMI, enrolled beyond the 24 hour limit). Read More

    Endothelial to mesenchymal transition contributes to arsenic-trioxide-induced cardiac fibrosis.
    Sci Rep 2016 Sep 27;6:33787. Epub 2016 Sep 27.
    Department of Pharmacology (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, 150081, China.
    Emerging evidence has suggested the critical role of endothelial to mesenchymal transition (EndMT) in fibrotic diseases. The present study was designed to examine whether EndMT is involved in arsenic trioxide (As2O3)-induced cardiac fibrosis and to explore the underlying mechanisms. Cardiac dysfunction was observed in rats after exposure to As2O3 for 15 days using echocardiography, and the deposition of collagen was detected by Masson's trichrome staining and electron microscope. Read More

    [Clinical significance of natriuretic peptides in the differential diagnosis of dyspnea].
    Vnitr Lek 2016 ;62(7-8):640-5
    Acute dyspnea is one of the most common emergency department symptoms. But early diagnosis and treatment could be e challenging because of multiple potential causes. The gold standard biomarkers in cardiac dyspnea are B-type natriuretic peptide (BNP) and N-terminal pro-B-type (natriuretic peptide NT-pro BNP), which play an important role in the diagnosis, prognosis, and management of acute decompensated heart failure. Read More

    12-lead electrocardiogram features of arrhythmic risk: A focus on early repolarization.
    World J Cardiol 2016 Aug;8(8):447-55
    Caterina Rizzo, Francesco Monitillo, School of Cardiology, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy.
    The 12-lead electrocardiogram (ECG) is still the most used tool in cardiology clinical practice. Considering its easy accessibility, low cost and the information that it provides, it remains the starting point for diagnosis and prognosis. More specifically, its ability to detect prognostic markers for sudden cardiac death due to arrhythmias by identifying specific patterns that express electrical disturbances of the heart muscle, which may predispose to malignant arrhythmias, is universally recognized. Read More

    Decreased a disintegrin-like and metalloprotease with thrombospondin type 1 motif 13 activity and neurologic outcome in patients with successful resuscitation of out-of-hospital cardiac arrest: A prospective observational study.
    J Crit Care 2017 Feb 13;37:13-18. Epub 2016 Aug 13.
    Department of Emergency and Critical Care Medicine/Emergency Center, Tohoku University Hospital, Sendai, Japan; Division of Emergency and Critical Care Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan. Electronic address:
    Purpose: The purpose of this study is to investigate the association between a disintegrin-like and metalloprotease with thrombospondin type 1 motif 13 (ADAMTS13) and neurologic outcome in patients with resuscitation of out-of-hospital cardiac arrest (R-OHCA).

    Materials And Methods: A prospective observational study of adult patients with R-OHCA was conducted. Plasma activity of ADAMTS13 and inflammatory markers, an immunologic marker, and a marker of endothelial damage were measured on admission and day 2. Read More

    The effect of sepsis and its inflammatory response on mechanical clot characteristics: a prospective observational study.
    Intensive Care Med 2016 Dec 3;42(12):1990-1998. Epub 2016 Sep 3.
    Haemostasis Biomedical Research Unit (HBRU), Morriston Hospital, Swansea, UK.
    Purpose: Sepsis and its progression are known to have a major influence on the coagulation system. Current coagulation tests are of limited use when assessing coagulation in sepsis patients. This study aims to assess the potential for a new functional biomarker of clot microstructure, fractal dimension, to identify changes in the mechanical properties of clot microstructure across the sepsis spectrum (sepsis, severe sepsis and septic shock). Read More

    Development and Validation of a Risk Stratification Score for Children With Congenital Heart Disease Undergoing Noncardiac Surgery.
    Anesth Analg 2016 Oct;123(4):824-30
    From the Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.
    Background: Children with major and severe congenital heart disease (CHD) undergoing noncardiac surgery are at increased risk of mortality. The objective of this study was to identify the predictors for in-hospital mortality, and to develop a risk stratification score that could be used to help decision making and the development of perioperative management guidelines.

    Methods: We included all children with major (eg, tetralogy of Fallot with wide open pulmonary insufficiency, hypoplastic left heart syndrome including stage 1 repair) or severe CHD (eg, children with uncorrected CHD, children with documented pulmonary hypertension, children with ventricular dysfunction requiring medications, or children listed for heart transplant) recorded in the 2012 and 2013 American College of Surgeons National Surgical Quality Improvement Program Pediatric databases in a derivation cohort, and those recorded in the 2014 database in a validation cohort. Read More

    Novel Therapeutic Role for Dipeptidyl Peptidase III in the Treatment of Hypertension.
    Hypertension 2016 Sep 25;68(3):630-41. Epub 2016 Jul 25.
    From the Division of Molecular Medical Biochemistry, Department of Biochemistry and Molecular Biology (X.P., A.S., S.Kurita, D.P.Z., K.T., H.O.), Division of Diabetology, Endocrinology, Nephrology, and Neurology, Department of Medicine, Shiga University of Medical Science, Otsu, Japan (M.Y-Y., S.Kume); Chemistry Division, Department of Chemistry, Biology and Marine Science, Faculty of Science, University of the Ryukyus, Nishihara-cho, Japan (T.I.); and Department of Emergency, The Fourth Affiliated Hospital of China Medical University, Shenyang, China (X.P.).
    Dipeptidyl peptidase III (DPP III) cleaves dipeptide residues from the N terminus of polypeptides ranging from 3 to 10 amino acids in length and is implicated in pathophysiological processes through the breakdown of certain oligopeptides or their fragments. In this study, we newly identified the biochemical properties of DPP III for angiotensin II (Ang II), which consists of 8 amino acids. DPP III quickly and effectively digested Ang II with Km = 3. Read More

    Procalcitonin is a strong predictor of urine culture results in patients with obstructing ureteral stones: A prospective, pilot study.
    Urol Ann 2016 Jul-Sep;8(3):277-80
    Department of Urology, Rush University Medical Center, Chicago, IL, USA.
    Purpose: The appropriate management of infected obstructing ureteral calculi is prompt genitourinary decompression. Urine cultures are the gold standard for confirming infection but often take 24-48 h to result. Although white blood cell (WBC) count is an important diagnostic laboratory test, it is a nonspecific inflammatory marker. Read More

    Circulating microRNAs and sudden cardiac arrest outcomes.
    Resuscitation 2016 Sep 14;106:96-101. Epub 2016 Jul 14.
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA; Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA, USA.
    Aim: MicroRNAs (miRNAs) have regulatory functions in organs critical in resuscitation from sudden cardiac arrest due to ventricular fibrillation (VF-SCA); therefore, circulating miRNAs may be markers of VF-SCA outcome.

    Methods: We measured candidate miRNAs (N=45) in plasma using qRT-PCR among participants of a population-based VF-SCA study. Participants were randomly selected cases who died in the field (DF, n=15), died in hospital (DH, n=15), or survived to discharge (DC, n=15), and, age-, sex-, and race-matched controls (n=15). Read More

    Echocardiographic left ventricular systolic dysfunction early after resuscitation from cardiac arrest does not predict mortality or vasopressor requirements.
    Resuscitation 2016 Sep 1;106:58-64. Epub 2016 Jul 1.
    Department of Emergency Medicine, University of Pittsburgh, 3600 Forbes Avenue, Suite 400A, Pittsburgh, PA 15261, United States. Electronic address:
    Background/aims: Echocardiographic abnormalities are common after resuscitation from cardiac arrest. The association between echocardiographic findings with vasopressor requirements and mortality are not well described. We sought to determine the associations between echocardiographic abnormalities and mortality, vasopressor requirements and organ failure after cardiac arrest. Read More

    N-acetylcysteine reduces the renal oxidative stress and apoptosis induced by hemorrhagic shock.
    J Surg Res 2016 Jun 2;203(1):113-20. Epub 2016 Mar 2.
    Department of Surgery, Federal University of São Paulo, São Paulo, São Paulo, Brazil.
    Background: Renal ischemia/reperfusion injury induced by hemorrhagic shock (HS) and subsequent fluid resuscitation is a common cause of acute renal failure. The objective of this study was to evaluate the effect of combining N-acetylcysteine (NAC) with fluid resuscitation on renal injury in rats that underwent HS.

    Materials And Methods: Two groups of male Wistar rats were induced to controlled HS at 35 mm Hg mean arterial pressure for 60 min. Read More

    Relative impact of amyloid-β, lacunes, and downstream imaging markers on cognitive trajectories.
    Brain 2016 Sep 21;139(Pt 9):2516-27. Epub 2016 Jun 21.
    1 Departments of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea 2 Neuroscience Center, Samsung Medical Center, Seoul, Korea 16 Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, Seoul, Korea
    SEE COHEN DOI101093/AWW183 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Amyloid-β and cerebral small vessel disease are the two major causes of cognitive impairment in the elderly. However, the underlying mechanisms responsible for precisely how amyloid-β and cerebral small vessel disease affect cognitive impairment remain unclear. We investigated the effects of amyloid-β and lacunes on downstream imaging markers including structural network and cortical thickness, further analysing their relative impact on cognitive trajectories. Read More

    Cardiopulmonary laboratory biomarkers in the evaluation of acute dyspnea.
    Open Access Emerg Med 2016 17;8:35-45. Epub 2016 May 17.
    Cardiovascular Division, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
    Dyspnea is a common chief complaint in the emergency department, with over 4 million visits annually in the US. Establishing the correct diagnosis can be challenging, because the subjective sensation of dyspnea can result from a wide array of underlying pathology, including pulmonary, cardiac, neurologic, psychiatric, toxic, and metabolic disorders. Further, the presence of dyspnea is linked with increased mortality in a variety of conditions, and misdiagnosis of the cause of dyspnea leads to poor patient-level outcomes. Read More

    Transgenic sickle cell trait mice do not exhibit abnormal thermoregulatory and stress responses to heat shock exposure.
    Blood Cells Mol Dis 2016 Jul 7;59:124-8. Epub 2016 May 7.
    Department of Military and Emergency Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.
    There remains controversy over whether individuals with sickle cell trait (SCT) are vulnerable to health risks during physical activity in high temperatures. We examined thermoregulatory and stress-related responses to heat exposure in SCT and wild-type (WT) mice. No significant differences in core temperature (Tc) were observed between SCT and WT mice during heat exposure. Read More

    Prediction of extravasation in pelvic fracture using coagulation biomarkers.
    Injury 2016 Aug 10;47(8):1702-6. Epub 2016 May 10.
    Department of Emergency Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan; Emergency and General Medical Center, Gunma University Hospital, Maebashi, Japan.
    Purpose: To evaluate the usefulness of coagulation biomarkers, which are easy and quick to analyze in emergency settings, for prediction of arterial extravasation due to pelvic fracture.

    Patients And Methods: The medical records of pelvic fracture patients transferred to the emergency department of Gunma University Hospital between December 2009 and May 2015 were reviewed. Patients were divided into two groups, those with (Extra(+)) and without (Extra(-)) arterial extravasation on enhanced CT or angiography. Read More

    REACTED - Reducing Acute Chest pain Time in the ED: A prospective pre-/post-interventional cohort study, stratifying risk using early cardiac multi-markers, probably increases discharges safely.
    Emerg Med Australas 2016 Aug 1;28(4):383-90. Epub 2016 Jun 1.
    School of Population Health, University of Western Australia, Perth, Western Australia, Australia.
    Objective: ED chest pain assessments can be challenging, lengthy and contribute to overcrowding. Rapid accurate risk stratification strategies should improve ED length of stay (EDLOS). Emergency, Biochemistry and Cardiology implemented new guidelines using paired (<3 h) multiple cardiac markers to stratify patients. Read More

    Chronic anabolic androgenic steroid usage associated with acute coronary syndrome in bodybuilder.
    Turk J Emerg Med 2016 Mar 10;16(1):35-7. Epub 2016 Mar 10.
    Department of Emergency Medicine, Bezmialem Vakif University Medical School, Istanbul, Turkey.
    Introduction: It has been argued in current studies that anabolic androgenic steroids (AAS) are misused by a great number of bodybuilders and athletes. However, there is diverse and often conflicting scientific data on the cardiac and metabolic complications caused by the misuse of AAS. There may be various reasons for myocardial infarction (MI) with normal coronary arteries. Read More

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