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Clin Case Rep 2021 May 9;9(5):e03872. Epub 2021 Apr 9.

Department of Dermatology Mayo Clinic Florida Jacksonville FL USA.

Recognize that delayed hypersensitivity reactions to sulfonamides may present as urticated plaques with hyperpigmentation and purpura for which a diagnosis of urticarial vasculitis should be considered. Read More

Pediatr Ann 2021 May 1;50(5):e191-e197. Epub 2021 May 1.

Urticaria (or hives) is a pruritic and erythematous skin rash. Angioedema commonly occurs with urticaria. The term "chronic urticaria" is used when hives are present for more than 6 weeks. Read More

Zhonghua Yi Xue Za Zhi 2021 Jun;101(20):1458-1462

Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.

Since the discovery of Epstein-Barr (EB) virus from the cultured cells in Burkitt lymphoma tissue in African children in 1964, we have gradually taken in its oncogenicity and the link between this virus and multiple mucocutaneous diseases. This review exhibits the process of EB virus infection and summarizes the clinical manifestations and varied prognosis of EB virus-associated skin diseases. The cases of common skin diseases including psoriasis, dermatomyositis, pemphigus, pemphigoid, parapsoriasis, atopic dermatitis, urticaria, systemic lupus erythematosus, scleroderma, panniculitis,erythema multiforme and vasculitis coinciding with EB virus infection were collected for the analysis of their EB virus-associated complications, treatments and outcomes. Read More

J Eur Acad Dermatol Venereol 2021 May 25. Epub 2021 May 25.

Laboratório Paulista de Dermatologia, São Paulo, Brazil.

Dermatol Ther 2021 May 18:e14984. Epub 2021 May 18.

Rutgers New Jersey Medical School, Newark, New Jersey, USA.

Cutaneous involvement can be an important sign of both COVID-19 and rickettsioses. Rickettsial infections may be first evident as an exanthem with eschars as a key finding. In contrast, eschars and necrotic lesions can be seen in critically ill COVID-19 patients. Read More

BMJ Case Rep 2021 May 10;14(5). Epub 2021 May 10.

Department of Immunology, Canberra Health Services, Garran, Australian Capital Territory, Australia.

Hypocomplementemic urticarial vasculitis syndrome (HUVS) is a rare autoimmune disorder characterised by recurrent urticarial lesions and acquired hypocomplementemia with systemic manifestations. The authors present the case of a 70-year-old man who presented to the ophthalmology clinic with bilateral scleritis and ocular hypertension. He was diagnosed with HUVS after a 6-month period of bilateral scleritis, vestibulitis, significant weight loss, mononeuritis multiplex and recurrent urticarial vasculitis with pronounced persistent hypocomplementemia and the presence of anti-C1q antibodies. Read More

Clin Transl Allergy 2021 Apr;11(2):e12031

Dermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Background: Urticarial vasculitis (UV) is defined by long-lasting urticarial lesions combined with the histopathologic findings of leukocytoclastic vasculitis. As one of the major unmet needs in UV, diagnostic criteria are rather vague and not standardized. Moreover, there seems to be considerable overlap with chronic spontaneous urticaria (CSU), particularly for the normocomplementemic variant of UV. Read More

J Asthma Allergy 2021 23;14:433-437. Epub 2021 Apr 23.

Department of Dermatology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.

Background: Urticarial vasculitis is a small vessel vasculitis characterized by long-lasting wheals. It was suggested omalizumab is well tolerated and effective in patients with hypocomplementaemic urticarial vasculitis.

Objective: To evaluate the clinical response and safety of omalizumab for treating patients with normocomplementaemic urticarial vasculitis (NUV) in real-world setting. Read More

JAAD Case Rep 2021 May 25;11:33-35. Epub 2021 Feb 25.

Department of Dermatology, University of New Mexico, Albuquerque, New Mexico.

Braz J Med Biol Res 2021 19;54(6):e10745. Epub 2021 Apr 19.

Departamento de Medicina, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil.

Episodic angioedema with eosinophilia (EAE) is a rare condition characterized by recurrent attacks of angioedema and urticaria accompanied by a marked elevation of peripheral eosinophil count. We report the case of a young female patient diagnosed with EAE associated with urticarial vasculitis. A 40-year-old female patient was admitted to our institution due to recurrent episodes of cheek and eyelid angioedema in the previous year. Read More

J Allergy Clin Immunol Pract 2021 Jun 20;9(6):2274-2283. Epub 2021 Apr 20.

Dermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. Electronic address:

Background: In chronic spontaneous urticaria (CSU), the guidelines recommend very limited diagnostic procedures during the routine workup, although additional investigations might be indicated in some patients with CSU. For physicians treating patients with CSU, it is often difficult to decide which diagnostic tests are useful.

Objective: To provide recommendations on what diagnostic tests should be performed on which patients with CSU. Read More

Rev Med Interne 2021 Apr 9. Epub 2021 Apr 9.

Service de dermatologie, hôpital Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94000 Créteil, France; UPEC, université Paris Est Créteil EpidermE, Créteil, France. Electronic address:

Introduction: Propylthiouracil (PTU) is a synthetic antithyroid drug that can induce ANCA-associated vasculitis.

Observation: A 27-year-old woman diagnosed with Graves' disease was on PTU for the past 10 years. She developed purpuric lesions of the legs and on the tip of the nose diagnosed as vasculitis. Read More

J Am Acad Dermatol 2021 07 7;85(1):46-55. Epub 2021 Apr 7.

Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Medical Practice Evaluation Center, Mongan Institute, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

Background: Cutaneous reactions after messenger RNA (mRNA)-based COVID-19 vaccines have been reported but are not well characterized.

Objective: To evaluate the morphology and timing of cutaneous reactions after mRNA COVID-19 vaccines.

Methods: A provider-facing registry-based study collected cases of cutaneous manifestations after COVID-19 vaccination. Read More

Cureus 2021 Feb 14;13(2):e13338. Epub 2021 Feb 14.

Internal Medicine, All India Institute of Medical Sciences, Bhubaneswar, IND.

Schnitzler syndrome (SS) is a rare disease of unknown etiology. Literature suggests that only around 300 well-diagnosed cases have only been reported worldwide and rarely from India. This syndrome has a slight male predominance with a mean age of onset of around 50 years. Read More

SAGE Open Med Case Rep 2021 23;9:2050313X21997194. Epub 2021 Feb 23.

Ecology of Pathogenic Agents Deparment, Researcher Division, General Hospital Dr. Manuel Gea González, Ciudad de México, México.

China officially recognized atypical pneumonia outbreak in December 2019; on 11 March 2020, the World Health Organization declared COVID-19 as a pandemic that is produced by a new coronavirus, named SARS-CoV-2, of rapid transmissibility, which can be asymptomatic, with mild to severe respiratory symptoms, and with cardiovascular, neurological, gastrointestinal, and cutaneous complications. Considering that the pandemic prolonged more than initially expected was prognostic, it is essential for the medical community to identify the signs and symptoms of COVID-19. Thus, this work's objectives were to present cases of cutaneous lesions observed in COVID-19 Mexican patients. Read More

Intern Emerg Med 2021 Jun 13;16(4):831-841. Epub 2021 Mar 13.

Dipartimento Di Scienze Cliniche E Molecolari, Clinica Medica, Università Politecnica Delle Marche, Via Tronto 10/A, 60127, Ancona, Italy.

Leukocytoclastic vasculitis (LCV) is a histopathologic description of a common form of small vessel vasculitis (SVV), that can be found in various types of vasculitis affecting the skin and internal organs. The leading clinical presentation of LCV is palpable purpura and the diagnosis relies on histopathological examination, in which the inflammatory infiltrate is composed of neutrophils with fibrinoid necrosis and disintegration of nuclei into fragments ("leukocytoclasia"). Several medications can cause LCV, as well as infections, or malignancy. Read More

Clin Rheumatol 2021 Mar 12. Epub 2021 Mar 12.

Department of Integrated Traditional Chinese and Western Medicine of Rheumatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.

Objective: This study aims to analyze the clinical characteristics of juvenile primary Sjogren's syndrome (pSS) with cutaneous involvement.

Methods: We investigated the clinical and immunological characteristics of 37 children with pSS. All the patients met the 2012 American College of Rheumatology Classification Criteria for Sjogren's syndrome. Read More

BMC Musculoskelet Disord 2021 Mar 8;22(1):257. Epub 2021 Mar 8.

Department of Rheumatology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, Fukushima, 960-1295, Japan.

Background: Schnitzler's syndrome (SchS) is a rare autoinflammatory syndrome with diagnostic challenge and be characterized by chronic urticaria, a monoclonal gammopath, periodic fever and bone pain. In addition to the monoclonal gammopathy, bone abnormalities are often found at the site of bone pain in patients with SchS. The remarkable efficacy of interleukin-1 (IL-1) inhibition was also demonstrated in this syndrome. Read More

Curr Allergy Asthma Rep 2021 02 25;21(2):13. Epub 2021 Feb 25.

Servicio de Dermatología, Hospital Infantil de Mexico Federico Gómez, Mexico City, Mexico.

Purpose Of Review: At the juncture of the COVID-19 pandemic, the world is currently in an early phase of collecting clinical data and reports of its skin manifestations, and its pathophysiology is still highly conjectural. We reviewed cutaneous manifestations associated with COVID-19 in the pediatric age group.

Recent Findings: Children infected by SARS-CoV-2 usually develop milder respiratory symptoms, but cutaneous manifestations seem a little more prevalent than in adults. Read More

Homeopathy 2021 05 22;110(2):132-136. Epub 2021 Feb 22.

Medical Homeopathic Association of São Paulo and Pontifical Catholic University of São Paulo, São Paulo, Brazil.

Thromboinflammation is a still not well-understood phenomenon, which has recently come to the foreground as a function of its relevance in the pathophysiology of coronavirus disease 2019 (COVID-19). The patient described in the present case report exhibited acute fever, giant urticaria, elevated acute phase reactants, and very high d-dimer levels, thus characterizing thromboinflammation. She was diagnosed as a COVID-19 suspect case, which was not confirmed; urticarial vasculitis was ruled out. Read More

J Cutan Pathol 2021 Feb 17. Epub 2021 Feb 17.

Department of Dermatology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Background: Chronic spontaneous urticaria (CSU) may occasionally exhibit long-lasting lesions with bruising, usually considered a hallmark of urticarial vasculitis (UV). Histopathology of these chronic urticarial lesions has not been extensively studied.

Methods: Skin biopsies from patients with anti-H1 resistant CSU were evaluated for several parameters (edema, location, intensity, and cell composition of the inflammatory infiltrate, and abnormalities in the blood vessels). Read More

Indian J Dermatol Venereol Leprol 2021 Jan-Feb;87(1):146

Department of Dermatology, Venereology, and Leprosy, R. G. Kar Medical College, Kolkata, West Bengal, India.

Rheumatology (Oxford) 2021 Feb 12. Epub 2021 Feb 12.

Department of Internal Medicine, Adolphe de Rothschild Foundation Hospital, Paris, France.

Dermatol Online J 2021 Jan 15;27(1). Epub 2021 Jan 15.

Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA.

The severe acute respiratory syndrome coronavirus two (SARS-CoV-2), which causes the 2019 coronavirus disease (COVID-19), has infected patients worldwide. Physicians have increasingly identified cutaneous findings as a significant clinical manifestation of COVID-19. In this review, we describe the clinical presentation, onset, duration, associated symptoms, treatment, and outcome of cutaneous manifestations thus far reported to be related to COVID-19. Read More

Allergol Immunopathol (Madr) 2021 2;49(1):87-94. Epub 2021 Jan 2.

Pediatrics Division, Hospital con Especialidades Juan María Salvatierra, La Paz Baja California Sur, Mexico.

Background: The Mexican Guidelines for the diagnosis and treatment of urticaria have been published. Just before their launch, physicians' knowledge was explored relating to key issues of the guidelines.

Objective: The aim of this study was to investigate the opinion of medical specialists concerning urticaria management. Read More

Front Pediatr 2020 7;8:614386. Epub 2021 Jan 7.

Department of Pediatrics, Kawasaki Disease Center, College of Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University, Kaohsiung, Taiwan.

Kawasaki disease (KD) is an inflammatory disorder with an unknown etiology. It is the leading cause of acquired heart disease, which leads to coronary vasculitis among children. Studies of frequent manifestation of allergic diseases in children with KD have been the subject of mounting clinical interest. Read More

J Nephrol 2021 06 12;34(3):953-957. Epub 2021 Jan 12.

Delray Medical Center, Delray Beach, Florida, USA.

Dermatol Ther 2021 Jan 10;34(1):e14731. Epub 2021 Jan 10.

Department of Dermatology and Venereology, Yıldırım Beyazıt University, Ankara City Hospital, Ankara, Turkey.

The current studies focus on the association between COVID-19 and certain comorbidities. To the best of our knowledge, the association between severe COVID-19 and dermatologic comorbidities has not been reported yet. In this study, we aimed to describe the dermatologic comorbidities of patients with severe COVID-19 and compare it with the control group. Read More

Adv Exp Med Biol 2021 Jan 1. Epub 2021 Jan 1.

Internal medicine, division of Clinical Immunology, Humanitas Clinical and Research Center - IRCCS, Milan, Italy.

Urticaria is characterized by the cutaneous presence of wheals (hives), angioedema or both. Acute and chronic urticaria are distinguished based on a duration of less or more than 6 weeks. Chronic urticaria can be further classified into a spontaneous form and several inducible types triggered by specific external stimuli. Read More

J Am Acad Dermatol 2020 Dec 19. Epub 2020 Dec 19.

Child Health Department, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat Oman.