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Cureus 2020 May 26;12(5):e8305. Epub 2020 May 26.

Dermatology, Largo Medical Center, Largo, USA.

Tumid lupus erythematosus (TLE) is a rare form of chronic cutaneous lupus that has triggered much debate regarding its clinical and histopathological features. It has been classically defined as annular erythematous, succulent, plaques involving the face and trunk that typically are devoid of any papulosquamous features such as scale and follicular plugging. These lesions are a clinical mimicker of other urticarial lesions such as urticarial vasculitis and lymphocytic infiltrate of Jessner. Read More

Hemoglobin 2020 Jul 1:1-3. Epub 2020 Jul 1.

Adult Thalassemia Unit, Second Department of Internal Medicine, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Necrobiosis lipoidica (NL) is a rare granulomatous disease that predominantly affects middle-aged women and is often associated with diabetes mellitus (DM), rheumatoid arthritis (RA) and other metabolic disorders. Thalassemias are the most common hereditary hemoglobin (Hb) disorders worldwide. A few studies investigated dermatologic problems that coexist with β-thalassemia major (β-TM). Read More

Clin Exp Dermatol 2020 Jun 29. Epub 2020 Jun 29.

Department of Dermatology, Ninewells Hospital and Medical School, Dundee, UK.

Classically, chronic urticaria has been treated following a stepwise approach where Omalizumab and other immunosuppressants occupy the last step. Omalizumab and Methotrexate have both been used separately for the treatment of urticaria . We believe combination treatment with both agents is a valuable alternative for refractory chronic urticaria and other related diseases such as urticarial vasculitis. Read More

J Investig Allergol Clin Immunol 2020 Jun;30(3):211-212

Hospital Universitario Fundación Alcorcón, Alcorcón (Madrid), Spain.

Indian J Dermatol 2020 May-Jun;65(3):208-210

Department of Internal Medicine, Baby Memorial Hospital, Kozhikode, Kerala, India.

Urticarial vasculitis (UV) is a form of cutaneous vasculitis which lasts for >24 h. Clinically, the patients present with erythema and wheals. The level of complement decides the type of UV. Read More

Acta Derm Venereol 2020 Jun 15. Epub 2020 Jun 15.

Department of Dermatology, Kyoto University Graduate School of Medicine, 606-8507 Kyoto, Japan.

J Eur Acad Dermatol Venereol 2020 Jun 8. Epub 2020 Jun 8.

Department of Dermatology, Hospital Universitario Ramon y Cajal, Madrid, Spain.

J Allergy Clin Immunol Pract 2020 Jun 3. Epub 2020 Jun 3.

Department of Internal Medicine, Cochin Hospital, Paris, France; National Referral Centre for Systemic and Autoimmune Diseases, Cochin Hospital, Paris, France; Paris Descartes University, Université de Paris, Paris, France. Electronic address:

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620929478

Lynchburg Nephrology Physicians, Lynchburg, VA, USA.

We sincerely thank Dr Andrew Whyte, who keenly reviewed our case report and came up with critical reasoning to justify his thoughts and critique with regard to our published article, "An Unusual Case of Acquired Angioedema and Monoclonal Gammopathy of Renal Significance in a Middle-Aged Caucasian Female." We agree with the author that hypocomplementemic urticarial vasculitis can be a reasonable contender as a diagnosis in this case. There are indeed some features in this case that do not entirely fit either classic presentation of acquired angioedema or hypocomplementemic urticarial vasculitis. Read More

Inflamm Res 2020 Aug 2;69(8):745-756. Epub 2020 Jun 2.

Department of Dermatology, Faculdade de Medicina do ABC, Príncipe de Gales, Avenida Príncipe de Gales, 821, Santo André, SP, 09060-650, Brazil.

Background: SARS-Cov-2 is a single-stranded RNA virus, a Betacoronavirus, composed of 16 non-structural proteins, with specific roles in replication of coronaviruses. The pathogenesis of COVID-19 is not yet fully understood. The virus and host factors interplay among distinct outcomes of infected patients. Read More

Arthritis Rheumatol 2020 May 18. Epub 2020 May 18.

Division of Rheumatology, Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, USA.

Objective: Cutaneous manifestations of anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV), including granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA), are poorly characterized. This study describes the dermatologic features of AAV and their association with systemic manifestations of vasculitis.

Methods: A cross-sectional study describing and comparing the cutaneous manifestations of AAV was performed using data from a large, international, collaborative effort to collect comprehensive clinical data on patients with vasculitis. Read More

Clin Rev Allergy Immunol 2020 May 6. Epub 2020 May 6.

Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP-HP, 27, rue du Faubourg Saint-Jacques, 75679, Paris Cedex 14, France.

Cutaneous vasculitis is an inflammatory disease affecting the dermal blood vessel walls. The skin is a privileged organ in the setting of vasculitis since it is easily accessible for physical examination and safe biopsy, allowing an accurate characterization of inflammatory lesions. The skin is often involved. Read More

Pediatr Dermatol 2020 May 5. Epub 2020 May 5.

Child Health Department, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman.

Background/objectives: To determine the prevalence of urticarial vasculitis (UV) in a pediatric systemic lupus erythematosus (pSLE) cohort of Arab ethnicity from Oman and to describe their demographic, clinical, and laboratory features.

Methods: We conducted a retrospective multicenter study among pediatric rheumatology centers in Oman over a 10-year period from 2008 to 2018. Analyses were performed using univariate statistics. Read More

J Eur Acad Dermatol Venereol 2020 Apr 27. Epub 2020 Apr 27.

Dermatology Department, Paris University, Saint-Louis Hospital, Paris, France.

Coronavirus 19 (COVID-19) was declared as a pandemic viral infection by the World Health organization on March 11 2020. Usual clinical manifestations of COVID-19 infection include fever, fatigue, myalgia, headache, diarrhea, dry cough, dyspnea that may lead to acute respiratory distress syndrome and death (1). Skin symptoms of COVID-19 have been poorly described but may include erythematous rash, urticaria and chicken pox like lesions (2-7). Read More

Clin Exp Rheumatol 2020 Apr 17. Epub 2020 Apr 17.

Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease, Rheumatology Unit of the Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Italy.

Objectives: To evaluate the efficacy of tumour necrosis factor (TNF)-α inhibitors in refractory non-infectious scleritis.

Methods: We carried out a retrospective study assessing the efficacy of TNF-α inhibitors in the treatment of scleritis, scleritis relapses, glucocorticoid (GC)-sparing effect, impact on best-corrected visual acuity (BCVA) and safety profile.

Results: Nineteen patients (28 eyes) were eligible for analysis. Read More

Sci Rep 2020 Apr 8;10(1):6092. Epub 2020 Apr 8.

Department of Dermatology, Central University Hospital of Asturias, Oviedo, Spain.

The clinical criteria for the diagnosis of urticarial vasculitis lack accuracy, according to previous studies. The aim of the study was to assess the accuracy of a clinical and a clinical-dermoscopic model for the differential diagnosis of chronic spontaneous urticaria (CSU) and urticarial vasculitis (UV). Dermoscopic images of lesions with histopathologically confirmed diagnosis of CSU and UV were evaluated for the presence of selected criteria (purpuric patches/globules (PG) and red linear vessels). Read More

Dermatology 2020 Mar 27:1-6. Epub 2020 Mar 27.

Pediatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Background: Mycoplasma pneumoniae pneumonia is sometimes associated with skin or mucous membrane eruptions. Available reviews do not address the association of Chlamydophila pneumoniae pneumonia with skin eruptions. We therefore conducted a systematic review of the literature addressing this issue. Read More

J Cutan Pathol 2020 Mar 20. Epub 2020 Mar 20.

Department of Pathology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.

We describe two cases of acute myeloid leukemia (AML) who presented with cutaneous manifestations. Leukemia cutis (LC) is the cutaneous presentation of any type of leukemia and occurs in 10% to 15% of patients with AML, but cutaneous infiltration of AML rarely precedes the involvement of the bone marrow or peripheral blood and is called as "aleukemia cutis." Our first case presented with facial skin thickening, a manifestation which is known as lionization and his initial clinical diagnosis was nonspecific allergic reaction. Read More

World Allergy Organ J 2020 Mar 5;13(3):100107. Epub 2020 Mar 5.

Dermatological Allergology, UCARE Charité, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.

Background: Urticarial vasculitis (UV) is a rare type of leukocytoclastic vasculitis characterized by long lasting urticarial skin lesions and poor response to treatment. As of yet, no clinical guidelines, diagnostic criteria, or treatment algorithms exist, and the approaches to the diagnostic workup and treatment of UV patients may differ globally. We conducted an online survey to examine how UV patients are diagnosed and treated by international specialists and to reveal the greatest challenges in managing UV patients worldwide. Read More

Clin Exp Dermatol 2020 Jul 22;45(5):630-632. Epub 2020 Apr 22.

Dermatology Department, Althaia, Xarxa Assistencial Universitària de Manresa, Manresa, Spain.

J Allergy Clin Immunol Pract 2020 Jun 5;8(6):2114-2117.e2. Epub 2020 Mar 5.

Dermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany. Electronic address:

J Drugs Dermatol 2020 Feb;19(2):145-154

Introduction: Allergic conditions frequently require treatment with antihistamines. First-generation antihistamines can potentially interfere with restful sleep, cause “morning after” effects, impair learning and memory, and reduce work efficiency. Second-generation antihistamines, such as bilastine, have been demonstrated to decrease allergy symptoms effectively without causing night-time sleep disturbances and related adverse events. Read More

Dermatol Ther 2020 Mar 17;33(2):e13237. Epub 2020 Feb 17.

Unidad de Gestión Clínica de Dermatología Médico-Quirúrgica y Venereología, Hospital Universitario Puerta del Mar, Cádiz, Spain.

Acta Derm Venereol 2020 02 5;100(4):adv00052. Epub 2020 Feb 5.

Department of Dermatology and Venereology, Herlev and Gentofte Hospital, University of Copenhagen, DK-2900 Hellerup, Denmark.

J Clin Pharm Ther 2020 Jan 28. Epub 2020 Jan 28.

Division of Advanced Preventive Medical Sciences, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

What Is Known And Objective: Tumour necrosis factor-α-blocking agents potentially cause vasculitis. However, no study has reported on the association between hypocomplementemic urticarial vasculitis (HUV) and certolizumab pegol (CZP) usage.

Case Description: We present the first case of HUV development during CZP treatment for rheumatoid arthritis. Read More

Nephrol Ther 2020 Mar 9;16(2):124-135. Epub 2020 Jan 9.

Centre universitaire des maladies rénales, CHU de Caen, avenue de la côte de Nacre, 14033 Caen cedex 9, France; Unicaen, UFR de médecine, Normandie Université, 2, rue des Rochambelles, 14032 Caen cedex, France. Electronic address:

Hypocomplementemic urticarial vasculitis is a rare systemic vasculitis, affecting small vessels, characterised by chronicle urticaria, hypocomplementemia, and systemic manifestations. Renal involvement, whose prevalence varies between 9% and 60%, is mainly glomerular. We here report the case of a 59 years old woman presenting kidney failure, associated with chronicle urticaria and arthralgias. Read More

Endocrinol Diabetes Metab Case Rep 2020 Jan 8;2020. Epub 2020 Jan 8.

Department of Endocrinology and Diabetes, Beaumont Hospital Dublin, Dublin, Ireland.

Summary: This case is the first to describe a patient who experienced concomitant agranulocytosis and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis as an adverse effect of propylthiouracil treatment for Graves' disease. A 42-year-old female with Graves' disease presented to the emergency department (ED) with a 2-week history of fevers, night sweats, transient lower limb rash, arthralgia, myalgia and fatigue. She had been taking propylthiouracil for 18 months prior to presentation. Read More

Allergy Asthma Clin Immunol 2020 3;16. Epub 2020 Jan 3.

1Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022 China.

Background: Cutis laxa is a connective tissue disease characterized by loose, wrinkled, and redundant skin. It is either inherited or acquired. In most cases, acquired cutis laxa is associated with neoplasms, drugs, and autoimmune diseases. Read More

JAAD Case Rep 2020 Jan 24;6(1):30-32. Epub 2019 Dec 24.

Apex Dermatology and Skin Surgery Center, Mayfield Heights, Ohio.

Pulm Pharmacol Ther 2020 02 11;60:101875. Epub 2019 Dec 11.

School and Unit of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy. Electronic address:

Montelukast the leukotriene receptor antagonist is an anti-inflammatory drug that causes bronchodilation and for this reason it is used to improve inflammatory states in asthma and allergic rhinitis. Montelukast is generally considered a safe drug with the occurrence of a few adverse drug reactions (ADRs) and anti-leucotrienes are usually well-tolerated by adults and young patients. Starting from these premises the purpose of this review is so give un up-to-date scenario about skin adverse reactions due to Montelukast administration. Read More

Indian Dermatol Online J 2019 Nov-Dec;10(6):650-656. Epub 2019 Nov 1.

Department of Dermatology, Christian Medical College, Vellore, Tamil Nadu, India.

Background: Skin problems are commonly encountered in the pediatric emergency department (PED). Although there are a few studies on the prevalence and spectrum of skin conditions in children attending the PED, only limited information is available on the outcome of the children with skin-related ailments requiring hospitalization.

Aim: To study the clinical profile of skin manifestations in children presenting to the PED over a period of one year and assess the impact of skin lesions on the clinical outcome. Read More

G Ital Dermatol Venereol 2019 Dec 4. Epub 2019 Dec 4.

DISSAL, Department of Dermatology, Ospedale Policlinico San Martino, Genoa, Italy.

Hepatotropic viral infections are a relevant global health problem and present multiple extrahepatic manifestations in addition to hepatic disease. Along with generic cutaneous symptoms correlated to the cholestatic liver disease that may arise during the infection, some cutaneous manifestations of hepatotropic viral infections are characteristic, enabling to suspect the underlying infection. This review will present the principal cutaneous manifestations of hepatotropic virus infection. Read More

Lakartidningen 2019 Nov 29;116. Epub 2019 Nov 29.

Institutionen för Kliniska vetenskaper, Reumatologi, Lunds universitet och Reumatologkliniken, Skånes universitetssjukhus - Lund, Sweden Institutionen för Kliniska vetenskaper, Reumatologi, Lunds universitet och Reumatologkliniken, Skånes universitetssjukhus - Lund, Sweden.

Although more than 45 years have passed since hypocomplementemic urticarial vasculitis (HUVS) was first described by McDuffie and colleagues at the Mayo clinic, data on epidemiology, disease outcomes, prognosis and clinical features are scarce. Recently, we published the first epidemiological study of HUVS including data on incidence, prevalence, disease outcomes, prognosis and clinical features using data from two separate Swedish regions during a period of 16 years. The estimation of incidence and prevalence rates indicates that HUVS is rare but not always benign. Read More

An Bras Dermatol 2019 Sep - Oct;94(5):594-602. Epub 2019 Oct 2.

Laboratory of Applied Research in Dermatology and Bartonella Infection, School of Medical Sciences, Universidade Estadual de Campinas, Campinas, SP, Brazil; Discipline of Dermatology, Department of Clinical Medicine, School of Medical Sciences, Universidade Estadual de Campinas, Campinas, SP, Brazil. Electronic address:

Bartonellosis are diseases caused by any kind of Bartonella species. The infection manifests as asymptomatic bacteremia to potentially fatal disorders. Many species are pathogenic to humans, but three are responsible for most clinical symptoms: Bartonella bacilliformis, Bartonella quintana, and Bartonella henselae. Read More

J Clin Rheumatol 2019 Nov 15. Epub 2019 Nov 15.

Rheumatology Division Internal Medicine Department School of Medicine The University of Jordan Amman, Jordan Nephrology Division Internal Medicine Department School of Medicine The University of Jordan Amman, Jordan

Front Immunol 2019 29;10:2448. Epub 2019 Oct 29.

Clinical Unit of Autoinflammatory Diseases and Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain.

Autoinflammatory diseases include disorders with a monogenic cause and also complex conditions associated to polygenic or multifactorial factors. An increased number of both monogenic and polygenic autoinflammatory conditions have been identified during the last years. Although skin manifestations are often predominant in monogenic autoinflammatory diseases, clinical and histopathological information regarding their dermatological involvement is still scarce. Read More

Pan Afr Med J 2019 12;33:191. Epub 2019 Jul 12.

Hôpital Civil Tétouan, Tétouan, Maroc.

In infants less than 2 years of age, acute hemorrhagic edema of infancy (AHEI) is characterized by the rapid onset of annular purpuric lesions associated with initially localized edemas affecting the extremities. This disorder is usually benign, without visceral involvement. Diagnosis is based on clinical examination, no specific laboratory findings exist and the histological examination of the lesions (which is unnecessary in the majority of cases) is most often nonspecific (sometimes patients have nonspecific leukocytoclastic vasculitis). Read More

Pan Afr Med J 2019 29;33:267. Epub 2019 Jul 29.

Centre Hospitalier Régional Tétouan, Tétouan, Maroc.

In infants less than 2 years of age, acute hemorrhagic edema of infancy (AHEI) is characterized by the rapid onset of purpuric annular lesions associated with initially local edemas of the extremities. In most cases, this disorder is benign, without visceral involvement and diagnosis is based on clinical examination. There are no specific laboratory data and the histological analysis of these lesions (which is unnecessary in the majority of cases) is usually unspecific (the patient sometimes has an unspecified leucocytoclasic vasculitis). Read More

Acta Derm Venereol 2019 10 30. Epub 2019 Oct 30.

Department of Dermatology, American University of Beirut, PO Box 11-0236, Riad El Solh, Beirut, Lebanon.

Formation of neutrophil extracellular traps has been implicated in autoimmunity. However, the presence and clinical relevance of neutrophil extracellular traps in immune-complex-mediated cutaneous small and medium vessel vasculitides has not been investigated. This study retrospectively analysed 72 patients with histology-proven hypersensitivity vasculitis (n = 21), IgA vasculitis (n = 22), urticarial vasculitis (n = 22), erythema elevatum diutinum (n = 3) and polyarteritis nodosa (n = 4). Read More

Ann Rheum Dis 2020 01 25;79(1):163-164. Epub 2019 Oct 25.

Department of Immunology, SA Pathology (Flinders Medical Centre), Bedford Park, SA, Australia

Dermatol Ther 2019 11 24;32(6):e13115. Epub 2019 Oct 24.

Dermatology Unit, Hospital Universitario San Cecilio, Granada, Spain.

A 42-year-old female with a personal history of Grade II infiltrating ductal breast carcinoma, treated under surgical procedure in 2018, whose hormonal profile included estrogen, progesteronic and HER-2 positive receptors, and a Ki67 proliferative index (20-25%), was referred to our dermatological outpatient clinic complaining worsening of her chronic spontaneous urticaria. The patient was under treatment with etuximide, exemestane, anastrozole, and trastuzumab. Our patient reported intermittent episodes of hives of 8 years of evolution with good control with second-generation antihistamines. Read More

CEN Case Rep 2020 Feb 4;9(1):30-35. Epub 2019 Oct 4.

Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka, 812-8582, Japan.

Hypocomplementemic urticarial vasculitis syndrome (HUVS) is a small vessel vasculitis characterized by hypocomplementemia and urticaria-like exanthema. Some cases also display abdominal pain and membranoproliferative glomerulonephritis (MPGN) with immune complex deposits. We treated a case of HUVS with biopsy-proven gastrointestinal vasculitis and atypical histological findings in a kidney biopsy. Read More

Best Pract Res Clin Rheumatol 2019 08 1;33(4):101440. Epub 2019 Oct 1.

Clinic of Dermatology, University Hospital of Coimbra, Portugal; Faculty of Medicine, University of Coimbra, Coimbra, Portugal. Electronic address:

Skin lesions occur, often at very early stages, in many of the most frequent inflammatory rheumatic diseases such as in systemic lupus erythematosus (SLE), dermatomyositis (DM), systemic sclerosis (SSc), Sjögren's syndrome, rheumatoid arthritis (RA), and psoriatic arthritis. It is important to recognize the different specific cutaneous lesions in SLE (e.g. Read More

J Eur Acad Dermatol Venereol 2020 Apr 28;34(4):685-690. Epub 2019 Oct 28.

Faculté de Médecine, Université de Strasbourg, and Clinique Dermatologique, Hôpitaux Universitaires, Strasbourg, France.

Neutrophilic urticarial dermatosis (NUD) has been described in 2009. Clinically, it is an eruption of rose or red macules or slightly elevated plaques, vanishing within 24 h. It occurs mostly on the trunk and the limbs. Read More

Antibodies (Basel) 2019 May 1;8(2). Epub 2019 May 1.

Department of Internal Medicine, Rheumatology and Immunology, Vasculitis-Center Tübingen-Kirchheim, Medius Klinik Kirchheim, University of Tübingen, 73230 Kirchheim-Teck, Germany.

Considerable progress has been made in understanding the role of autoantibodies in systemic vasculitides (SV), and consequently testing for anti-neutrophil cytoplasmic antibodies (ANCA), anti-glomerular basement membrane antibodies (anti-GBM), and anti-C1q antibodies is helpful and necessary in the diagnosis, prognosis, and monitoring of small-vessel vasculitis. ANCA-directed proteinase 3 (PR3-) or myeloperoxidase (MPO-) are sensitive and specific serologic markers for ANCA-associated vasculitides (AAV), anti-GBM antibodies are highly specific for the patients with anti-GBM antibody disease (formerly Goodpasture's syndrome), and autoantibodies to C1q are characteristic of hypocomlementemic urticarial vasculitis syndrome (HUVS; anti-C1q vasculitis). The results of a current EUVAS study have led to changes in the established strategy for the ANCA testing in small-vessel vasculitis. Read More

Dermatol Online J 2019 Jul 15;25(7). Epub 2019 Jul 15.

Division of Dermatology, Department of Medicine, University of Washington, Seattle, WA.

Angioimmunoblastic T-cell lymphoma (AITL) is a rare form of non-Hodgkin lymphoma often accompanied by autoimmune and paraneoplastic phenomena. Up to 50% of patients with AITL present with skin manifestations. This case series highlights two cases of AITL presenting with unusual cutaneous findings: one with a medium-vessel vasculitis and another with a chronic urticarial eruption. Read More

J Vet Emerg Crit Care (San Antonio) 2019 Sep 26;29(5):558-563. Epub 2019 Aug 26.

Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, 80523.

Objective: To describe a case of documented serum sickness in a dog following administration of a single dose of a novel antivenin crotalidae polyvalent.

Case Summary: A 4-year-old female neutered mixed breed dog developed recurrent signs of hypersensitivity (swelling, edema, urticaria/hives, gastrointestinal signs, vasculitis) at 1 and 2 weeks following administration of a single unit of a novel antivenin crotalidae polyvalent plasma product. Both episodes were treated with antihistamines and glucocorticoids and signs improved rapidly, with a prolonged course of glucocorticoids and antihistamines administered following the second occurrence. Read More

Am J Dermatopathol 2020 Jun;42(6):399-406

Department of Dermatology, Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands.

Urticarial vasculitis (UV) is a clinicopathologic entity characterized by persistent urticarial lesions with biopsy features of vasculitis. Currently, only certain clinical features such as arthralgia and serum complement concentrations are used to identify UV patients at risk for an underlying systemic disease. Hypocomplementemic urticarial vasculitis (HUV) is in contrast to normocomplementemic urticarial vasculitis (NUV), strongly associated with underlying systemic disease, especially systemic lupus erythematosus (SLE). Read More

Clin Exp Ophthalmol 2019 Nov 6;47(8):1097-1101. Epub 2019 Sep 6.

Gold Coast University Hospital, Southport, Queensland, Australia.

Medicine (Baltimore) 2019 Jul;98(28):e16382

Hematology Department.

Rationale: Type I monoclonal cryoglobulinemia is usually associated with lymphoproliferative disorders, such as monoclonal gammopathy of undetermined significance (MGUS), myeloma, chronic lymphocytic leukemia (CLL) and lymphoplasmocytic lymphoma (LPL). Clinical symptoms related to Type I cryoglobulin (CG) isotype often include skin, neurological and renal manifestations.

Patient Concerns: A 42-year-old woman who initially presented urticaria, palpable purpura in both her upper extremities and legs, eosinophilia and Raynaud phenomenon. Read More