Int J Dermatol 2017 Nov 19;56(11):1130-1138. Epub 2017 Sep 19.

First Department of Pediatrics, University of Athens, Aghia Sofia Children's Hospital, Athens, Greece.

Background: Existing studies of children with vasculitis are limited. The aim of this study was to assess the epidemiology, clinical manifestations, laboratory findings, course, and outcome of Greek children presenting with vasculitic rash.

Methods: The relevant data included in the study were collected retrospectively using a standardized form from children who were admitted into our department between 2003 and 2013, with the provisional diagnosis of vasculitis of the skin. Read More

Autoimmun Rev 2017 Sep 14. Epub 2017 Sep 14.

Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France; Faculté de Médecine, Université Paris Descartes, Sorbonne Paris Cité, Paris, France. Electronic address:

Objectives: Cutaneous manifestations (CM) in ANCA-associated vasculitides (AAV) are frequent, but data on clinical significance and clinical-pathological correlations are lacking.

Methods: We conducted a multicenter, retrospective study including 1553 AAV patients. Clinical, biological and pathological features have been analyzed, and tissue samples from 46 biopsies were reviewed in a blind manner. Read More

J Allergy Clin Immunol Pract 2017 Sep 6. Epub 2017 Sep 6.

Department of Internal Medicine, Division of Allergy & Immunology, University of Texas Southwestern Medical Center, Dallas, Tex. Electronic address:

Background: Chronic urticaria (CU) is urticaria that has been present continuously or intermittently for at least 6 weeks. Although the prevalence and characteristics of CU are well established, little is known about recurrent CU (RCU).

Objectives: We sought to establish a definition, determine the frequency, and evaluate risk factors for RCU. Read More

Am J Dermatopathol 2017 Oct;39(10):753-759

*Department of Dermatology, Sheba Medical Center, Tel-Hashomer, Israel; and †Institute of Pathology, Sheba Medical Center, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: The classic histopathological findings of urticaria include dermal edema and a sparse perivascular infiltrate of neutrophils, eosinophils, macrophages, and lymphocytes. However, this pattern is inconsistently described.

Objective: To describe the histological and immunofluorescence characteristics of urticaria and to identify distinctive patterns. Read More

Clin Rev Allergy Immunol 2017 Aug 24. Epub 2017 Aug 24.

Pediatric Department of Southern Switzerland, San Giovanni Hospital, 6500, Bellinzona, Switzerland.

In childhood, cutaneous small-vessel vasculitides include Henoch-Schönlein syndrome, a systemic vasculitis, and Finkelstein-Seidlmayer syndrome, a skin-limited vasculitis. Both Henoch-Schönlein and Finkelstein-Seidlmayer syndromes are seen more frequently in white or Asian compared with black children and occur especially in winter and spring with a male-to-female ratio of approximately 2:1. In everyday clinical practice, both conditions are diagnosed on clinical grounds without histological confirmation. Read More

Clin Case Rep 2017 Aug 21;5(8):1255-1257. Epub 2017 Jun 21.

Department of DermatologyHospital Universitario Severo OchoaAvenida de Orellana28911LeganésMadridSpain.

Annular urticarial lesions in a child must establish a main differential diagnosis with urticaria multiforme, common urticaria, acute hemorrhagic edema of infancy, erythema marginatum, erythema annulare centrifugum, annular erythema in childhood, erythema multiforme, Sweet's syndrome, Schönlein-Henoch purpura, erythematosus lupus, several systemic vasculitis, and serum sickness. Read More

Reumatismo 2017 Aug 3;69(2):88-91. Epub 2017 Aug 3.

Rheumatology Unit, San Giovanni di Dio Hospital, Florence.

Jaccoud's arthropathy (JA) is a chronic, non erosive, rheumatoid-like deformity associated with rheumatic fever (RF) and systemic lupus erythematosus and with other diseases such as psoriatic arthritis, connective tissue diseases, hypocomplementemic urticarial vasculitis, infections, sarcoidosis and neoplasia. We described a case of JA in a patient with cutaneous psoriasis but with a particular disease evolution associated with idiopathic retropritoneal fibrosis (IRF), evaluated with computed tomography, magnetic resonance and 18F-FDG PET/ CT. The patient, following failure with steroids, methotrexate and etanercept, was treated with tocilizumab (8 mg/kg) once every 4 weeks for 6 months. Read More

Saudi J Kidney Dis Transpl 2017 Jul-Aug;28(4):929-933

Department of Pediatrics, Salmaniya Medical Complex, Manama, Kingdom of Bahrain.

Hypocomplementic urticarial vasculitis syndrome (HUVS) is an autoimmune disease characterized by recurrent urticaria, arthritis, and glomerulonephritis (GN). Anti-C1q antibody is the marker of HUVS together with low levels of classical pathway complements which are C2, C3, C4, and C1q. We report a case of a 6-year-old boy who presented with episodes of rashes, injected conjunctiva, abdominal pain, and arthritis, diagnosed as HUVS. Read More

J Hand Surg Am 2017 Sep 12;42(9):737-746. Epub 2017 Jul 12.

Department of Orthopedic Surgery, Division of Hand Surgery, Mayo Clinic, Rochester, MN. Electronic address:

All metals implanted into a biological system undergo some degree of corrosion depending upon its composition. The electrochemical process of corrosion produces free metal ions, which may activate the host's immune system through a variety of mechanisms. Whereas dermal metal hypersensitivity is common, affecting 10% to 15% of the population, the immune reaction from implanted metals is much less common (< 0. Read More

J Biol Regul Homeost Agents 2017 APR-JUN;31(2 Suppl. 2):57-77

Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.

Helicobacter pylori is a gram-negative, flagellate, microaerophilic bacterium identified for the first time about 30 years ago, as a pathogenic factor of gastritis and peptic ulcer. Soon after, it was linked to several gastrointestinal and extra-gastrointestinal diseases (hematological, cardiovascular, neurological, pulmonary and ocular diseases, obesity, diabetes mellitus, growth retardation and extragastric MALT lymphoma). Association and possible cause-effect correlation with H. Read More

Case Rep Dermatol 2017 May-Aug;9(2):40-43. Epub 2017 Jun 14.

Department of Dermatology, Tokyo Medical University, Tokyo, Japan.

The etiology of purpura in Sjögren syndrome (SS) includes cryoglobulinemia, hypergammaglobulinemia, and leukocytoclastic vasculitis (LCV). The clinical symptoms of LCV associated with SS comprise palpable or nonpalpable purpura and urticarial vasculitis. Here, we report a case of LCV presenting as erythema gyratum repens (EGR)-like purpura in a 62-year-old woman with rheumatoid arthritis and SS. Read More

NPJ Parkinsons Dis 2017 23;3:10. Epub 2017 Mar 23.

Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE USA.

A potential therapeutic role for immune transformation in Parkinson's disease evolves from more than a decade of animal investigations demonstrating regulatory T cell (Treg) nigrostriatal neuroprotection. To bridge these results to human disease, we conducted a randomized, placebo-controlled double-blind phase 1 trial with a well-studied immune modulator, sargramostim (granulocyte-macrophage colony-stimulating factor). We enrolled 17 age-matched non-Parkinsonian subjects as non-treated controls and 20 Parkinson's disease patients. Read More

Presse Med 2017 May 10;46(5):547-550. Epub 2017 May 10.

CHU de Grenoble, service de médecine interne, BP 2017, 38043 Grenoble cedex 09, France.

Rev Med Interne 2017 Apr 27. Epub 2017 Apr 27.

Service de médecine interne, faculté de médecine, centre de référence national pour les maladies auto-immunes et systémiques rares, en particulier les vascularites systémiques, hôpital Cochin, université Paris-Descartes, Assistance publique-Hôpitaux de Paris, 75014 Paris, France. Electronic address:

Hypocomplementemic urticarial vasculitis (HUV), called anti-C1q vasculitis in the 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides, is a rare systemic vasculitis of unknown etiology, affecting small vessels. HUV is characterized by urticarial lesions, hypocomplementemia and systemic manifestations, mostly musculoskeletal and ocular, but also gastrointestinal, pulmonary and kidney involvement. Anti-C1q antibodies are detected in only half of the patients, and low C1q seems to represent a more sensitive marker. Read More

Cutis 2017 Mar;99(3):189-192

Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, USA.

Imatinib mesylate (imatinib) is a tyrosine kinase inhibitor initially approved by the US Food and Drug Administration in 2001 for chronic myeloid leukemia (CML). Since then, the number of indicated uses for imatinib has substantially increased. It is increasingly important that dermatologists recognize adverse cutaneous manifestations of imatinib and are aware of their management and outcomes to avoid unnecessarily discontinuing a potentially lifesaving medication. Read More

Ann Allergy Asthma Immunol 2017 Apr;118(4):394-398

Department of Medicine, Wake Forest School of Medicine and the Wake Baptist Hospital, Winston Salem, North Carolina; W.G. (Bill) Hefner Veterans Affairs Medical Center, Salisbury, North Carolina; Kernersville Health Care Center, Kernersville, North Carolina. Electronic address:

Medicine (Baltimore) 2017 Mar;96(12):e6376

aDepartment of Dermatology b2nd Department of Medicine, Jagiellonian University Medical College, Cracow, Poland.

Leukocytoclastic vasculitis (LCV) is a heterogenous group of disorders that may manifest as a mild disease isolated to the skin or be a part of life-threatening systemic vasculitis. According to the 2012 Chapel Hill Consensus Conference nomenclature, patients presenting symptoms of LCV confined only to the skin should be defined as suffering from a single-organ cutaneous small vessel vasculitis (SoCSVV). SoCSVV is a benign disease with a good clinical outcome but with a significant risk of relapse and skin ulcer formation. Read More

J Eur Acad Dermatol Venereol 2017 Sep 29;31(9):e395-e397. Epub 2017 Mar 29.

Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Leipzig, 04103, Leipzig, Germany.

Clin Exp Dermatol 2017 Mar 1. Epub 2017 Mar 1.

Department of Dermatology, Hospital Clinico Universitario San Carlos, Madrid, Spain.

Urticarial vasculitis (UV) is a mainly leucocytoclastic vasculitis with urticarial plaques. Treating these patients is challenging as the available treatments have poor efficacy. Oral corticosteroids are considered the first-line treatment, but H1 antihistamines, dapsone, colchicine, antimalarials, ciclosporin and antileucotrienes have all been tried also. Read More

FP Essent 2017 Feb;453:18-25

University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.

Cutaneous adverse drug reactions are among the most common noninfectious rashes of childhood. Cutaneous adverse drug reactions are classified as morbilliform, urticarial, bullous, pustular, or psoriasiform. Atopic dermatitis is one of the most common inflammatory cutaneous eruptions, and is characterized by pruritus and flexural distribution. Read More

Pan Afr Med J 2016 28;24:285. Epub 2016 Jul 28.

Service de Pneumologie, Hôpital Militaire Mohamed V, Rabat, Maroc.

Pulmonary involvement in hypocomplementemic urticarial vasculitis (HUV) or Mac Duffie syndrome is extremely rare with a poor prognosis. We report the case of a 55-year-old female patient treated for HUV over a period of 20 years. The diagnosis was confirmed on the basis of urticarial lesions, ocular inflammation, positive C1q-p test by immunodiffusion, with low rate of C1q. Read More

Semin Diagn Pathol 2017 May 14;34(3):273-284. Epub 2016 Dec 14.

Section of Dermatopathology, Division of Surgical Pathology & Cytopathology, University of Virginia Medical Center, Room 3020 University of Virginia Hospital, 1215 Lee Street, Charlottesville, VA 22908-0214, USA. Electronic address:

Some cutaneous inflammatory disorders are typified by a predominant or exclusive localization in the dermis. They can be further subdivided by the principal cell types into lymphocytic, neutrophilic, and eosinophilic infiltrates, and mixtures of them are also seen in a proportion of cases. This review considers such conditions. Read More

Allergol Immunopathol (Madr) 2017 Mar - Apr;45(2):134-144. Epub 2016 Oct 28.

Pneumology and Allergy Service, Hospital Clinic (ICT), University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) [August Pi i Sunyer Biomedical Research Institute], Barcelona, Spain.

Background: Chronic spontaneous urticaria (CSU) is a frequent clinical entity that often presents a diagnostic and therapeutic challenge.

Objective: To explore the degree of agreement that exists among the experts caring for patients with CSU diagnosis, evaluation, and management.

Methods: An online survey was conducted to explore the opinions of experts in CSU, address controversial issues, and provide recommendations regarding its definition, natural history, diagnosis, and treatment. Read More

Clin Dermatol 2017 Jan - Feb;35(1):68-80. Epub 2016 Sep 10.

Department of Dermatology and Venereology, Tokuda Hospital Sofia, Sofia, Bulgaria.

Purpuric lesions appear in acral distribution in a variety of conditions and often provide clues to the clinical diagnosis. Purpuric means "hemorrhagic"-that is, the lesions do not blanch from pressure. This review focuses on dermatoses that produce hemorrhagic lesions in acral distribution from the large groups of the vasculitic diseases and their mimics. Read More

Rheumatol Int 2017 May 5;37(5):837-840. Epub 2016 Dec 5.

Department of Woman, Child and of General and Specialized Surgery, Università della Campania "Luigi Vanvitelli", Via Luigi De Crecchio 2, 80138, Naples, Italy.

A 17-year-old female patient affected by systemic lupus erythematosus (SLE) (who had been taking 300 mg/die of hydroxychloroquine for 3 years), Graves' disease (treated with 10 mg/die of tapazole), and celiac disease came to our attention for urticarial vasculitis. She had been taking prednisone (25 mg/die) for 3 days, and her blood tests showed high levels of Mycoplasma pneumoniae IgM and IgG antibodies. The association between urticaria and M. Read More

Reumatol Clin 2016 Dec 1. Epub 2016 Dec 1.

Servicio de Anatomía Patológica, Hospital General Universitario Gregorio Marañón, Madrid, España.

Intern Med 2016;55(22):3235-3237. Epub 2016 Nov 15.

Kubota Thyroid Clinic, Japan.

Objective When patients with Graves' disease show severe allergic cutaneous reactions, physicians often suggest that they undergo radioiodine therapy instead of receiving propylthiouracil (PTU), another antithyroid drug, because anti-neutrophil cytoplasmic antibody (ANCA) -related vasculitis can occur with PTU, especially with long-term use. However, some patients refuse radioiodine therapy and chose PTU. Sometimes PTU treatment may be prolonged. Read More

Eur Ann Allergy Clin Immunol 2016 Nov;48(6):247-250

Facultade de Medicina do ABC (FMABC), Santo André (SP), Brazil.

We report a first case of hypocomplementemic urticarial vasculitis of C2 fraction in a child, with cutaneous manifestation only, with no reports in scientific literature. Read More

Lupus 2017 Jun 12;26(7):768-772. Epub 2016 Nov 12.

1 Division of Rheumatology, Institute of Rheumatology, Catholic University School of Medicine, Rome, Italy.

We describe the third family in the world, after Arabian and Turkish ones, displaying an autosomal recessive autoimmune disease (AID), mimicking systemic lupus erythematosus (SLE), with unusual manifestations due to a homozygous frame-shift variant in DNASE1L3. SLE is a complex AID characterized by multiple organ involvement. Genetic risk variants identified account for only 15% of SLE heritability. Read More

Case Rep Pediatr 2016 13;2016:1691290. Epub 2016 Oct 13.

Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Grattan Street, Parkville, VIC, Australia.

Urticaria is common in children. Urticarial vasculitis (UV) is a potentially more serious, rare variant. The youngest reported case was 12 months of age. Read More

J Dermatolog Treat 2017 Jun 7;28(4):332-337. Epub 2016 Nov 7.

a Division of Dermatology, Department of Medicine , University of Calgary , Calgary , Alberta , Canada.

Purpose: Omalizumab is a recombinant humanized monoclonal antibody that inhibits the binding of immunoglobulin E (IgE) to the high-affinity IgE receptor (FceRI) on the surface of mast cells and basophils. Omalizumab has been approved for use in asthma, and new reports show promise in a variety of dermatologic diseases. Herein, we review the literature on omalizumab in dermatology and discuss the safety, efficacy and mechanisms of action for this emerging therapy. Read More

Semin Arthritis Rheum 2016 Dec 20;46(3):367-371. Epub 2016 Jul 20.

Rheumatology Unit, Bnai-Zion Medical Center, 47 Eliyahu Golomb St, Haifa, 33048 Israel.

Autoinflammatory diseases are characterized by recurrent episodes of fever and localized or systemic inflammation and are caused by monogenic defects of innate immunity. The skin is commonly involved with various manifestations including erysipelas like rash and urticaria. Although vasculitis has been described in many autoinflammatory diseases, it has not been recognized as a characteristic feature of these diseases and autoinflammatory diseases are not listed as an etiology for vasculitis associated with a systemic disease in the 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Read More

J Eur Acad Dermatol Venereol 2017 Mar 19;31(3):544-549. Epub 2016 Sep 19.

Department of Dermatology, Mayo Clinic, Rochester, MN, USA.

Background: Leukocytoclastic vasculitis (LCV) in children is a complex group of conditions.

Objectives: This study presents the demographics, clinical features, direct immunofluorescence (DIF) results and suspected aetiologies of 56 biopsy-confirmed cases of leukocytoclastic vasculitis in children.

Methods: Retrospective review of 56 children seen at Mayo Clinic in Rochester, Minnesota, from 1993 to 2013 with clinical features and cutaneous biopsy consistent with LCV. Read More

Intern Med 2016 1;55(15):2077-80. Epub 2016 Aug 1.

Department of General Internal Medicine, Kobe City Medical Center General Hospital, Japan.

The detection of abnormalities of the cranial arteries on magnetic resonance imaging (MRI) is useful for the diagnosis of giant cell arteritis (GCA). However, reports on the veins of GCA patients are rare. We report the case of an elderly woman with GCA who presented with facial edema. Read More

Rev Med Interne 2016 Dec 19;37(12):857-858. Epub 2016 Jul 19.

Service de rhumatologie, CHU Lamine Debaghine, boulevard Saïd Taouti, Bab El Oued, 16000 Alger, Algérie.

Int Arch Allergy Immunol 2016 21;170(2):92-6. Epub 2016 Jul 21.

Department of Plastic and Reconstructive Surgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Background: Kawasaki disease (KD) is an acute, systemic vasculitis in children, with an etiology that is not completely understood. It is assumed that the development of KD is mediated by an immunologic response. Several reports from East Asia have found a higher prevalence of atopic diseases among patients with KD, but a large-scale study of a non-Asian population regarding this correlation is still lacking. Read More

J Cutan Med Surg 2016 Nov 29;20(6):575-578. Epub 2016 Jun 29.

Division of Dermatology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.

Background: Schnitzler syndrome (SS) is a rare autoinflammatory disorder characterized by a recurrent urticarial rash and a monoclonal immunoglobulin M gammopathy, as well as 2 of the following minor criteria: recurrent fever (>38°C), objective signs of abnormal bone remodeling, elevated C-reactive protein level or leukocytosis, and a neutrophilic infiltrate on skin biopsy. Alternatively, a monoclonal immunoglobulin G gammopathy may be present along with 3 minor criteria for diagnosis.

Objective: To report a rare case of SS without monoclonal gammopathy and inform physicians of this possible clinical presentation so that treatment is not delayed. Read More

Indian J Dermatol Venereol Leprol 2016 Nov-Dec;82(6):626-640

Department of Dermatology, Venereology and Leprosy, Shri B. M. Patil Medical College, Hospital and Research Center, BLDE University, Vijayapur, Karnataka, India.

Anticoagulants are the cornerstone of treatment of venous thromboembolism associated with various medical conditions and surgical procedures. They act on different steps of the coagulation pathway and are broadly categorized into heparins, vitamin K antagonists, and inhibitors of thrombin and factor Xa. The classification is evolving as newer and better oral and parenteral anticoagulants are being added. Read More

JAAD Case Rep 2016 Mar 16;2(2):153-5. Epub 2016 Apr 16.

Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.

Case Rep Gastrointest Med 2016 17;2016:8603679. Epub 2016 Apr 17.

Division of Gastroenterology and Hepatology, Veterans Affairs Maryland Health Care System, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Urticarial vasculitis (UV) is a rare small vessel vasculitis. UV is often idiopathic but can also present in the context of autoimmune disorders such as systemic lupus erythematosus, drug reactions, infections, or a paraneoplastic syndrome. Extracutaneous complications include intestinal ischemic injuries, in UV patients with nonspecific gastrointestinal symptoms such as abdominal pain and nausea. Read More

Curr Rheumatol Rep 2016 Jun;18(6):36

Research Center of Systemic Autoinflammatory Diseases and Behçet's Disease Clinic, Department of Medical Sciences, Surgery and Neurosciences, University of Siena, Siena, Italy.

Inflammation mediated by cells of the immune system and necrosis are the most striking features observed at the histologic level in patients with vasculitides, clinical entities classified according to pathologic findings involving different organs, to etiology, or to size of vessels involved. Small vessel vasculitides (SVV) are a peculiar group of systemic disorders electively involving small intraparenchymal arteries, arterioles, capillaries, or venules and leading to different levels of vascular obstruction, tissue ischemia and risk of infarction; they can be divided into anti-neutrophil cytoplasmic antibody-associated vasculitides and immune complex vasculitides. Despite the significant advances in understanding the whole disease process and pathophysiology of SVV, strong efforts are still needed to draft, share and spread guidelines in the therapeutic management of these protean disorders. Read More

S Afr Med J 2016 Mar 17;106(4):48-50. Epub 2016 Mar 17.

Anatomy and Histopathology, Medical Biosciences Department, University of the Western Cape, Cape Town; Mbeya Referral Hospital, Ministry of Health and Social Welfare, Mbeya, Tanzania.

Autoimmune progesterone dermatitis (APD) is a rare autoimmune response to raised endogenous progesterone levels that occur during the luteal phase of the menstrual cycle. Cutaneous, mucosal lesions and other systemic manifestations develop cyclically during the luteal phase of the menstrual cycle when progesterone levels are elevated. APD symptoms usually start 3 - 10 days before menstruation and resolve 1 - 2 days after menstruation ceases. Read More

Postepy Dermatol Alergol 2016 Feb 29;33(1):13-7. Epub 2016 Feb 29.

Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland.

Introduction: Lupus erythematosus (LE) shows a wide variety of clinical manifestations, skin involvement being one of the most important.

Aim: To analyze the clinical presentation of cutaneous variants of lupus erythematosus in terms of skin lesion spectrum and extracutaneous involvement.

Material And Methods: A total of 64 patients with cutaneous LE (CLE) were included. Read More

Reumatizam 2015 ;62(2):6-10

The aim of our study was to analyze clinical features, laboratory findings, treatment, course and outcome of different types of vasculitis in children. All children aged up to 18 years that have been diagnosed with a vasculitis disorder from 2002. to 2012. Read More

Cent Eur J Immunol 2015 15;40(4):489-92. Epub 2016 Jan 15.

Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland.

Mycoplasma pneumoniae is one of the most common causes of respiratory tract infections in children. Extrapulmonary manifestations are seen in up to 25% of infected patients. Extrapulmonary complications are associated with the central nervous system, gastrointestinal tract, skin changes, myocarditis, pericarditis, hemolytic anemia, thrombocytopenia and thrombosis. Read More

Dermatol Res Pract 2015 29;2015:182609. Epub 2015 Dec 29.

Faculty of Medicine, Clinical Pathology Department, Tanta University Hospitals, El Geish Street, Tanta, Gharbia Governorate 31111, Egypt.

Background. Hepatitis C is a global major health problem with extremely variable extrahepatic manifestations. Mixed cryoglobulinaemia (MC) shows a striking association with hepatitis C virus (HCV) infection, and it is sometimes asymptomatic. Read More

Am J Dermatopathol 2016 Feb;38(2):e22-6

Department of Pathology, Albany Medical College, Albany, NY.

Neutrophilic dermatosis (ND) confined to postmastectomy lymphedema, localized Sweet syndrome, is a newly recognized disease. In this study, the authors describe a 44-year-old obese woman with chronic myelogenous leukemia in molecular remission on dasatinib therapy, who presented with a painful urticarial eruption limited to lipo-lymphedematous skin and accompanied by malaise, episodic fever, diarrhea, neutrophilia, and leukocytosis. Initially transient and migratory, the rash became fixed, papular, and vesicular and showed minimal response to corticosteroids. Read More

Am J Emerg Med 2016 May 25;34(5):936.e3-6. Epub 2015 Sep 25.

Department of Emergency Medicine, Division of Pediatric Emergency Medicine, Mayo Clinic, Rochester, MN 55905.

Acute hemorrhagic edema of infancy (AHEI) is a rare acute benign cutaneous leukocytoclastic vasculitis affecting children younger than 24 months of age. Its presentation can be confused with those of urticaria, erythema multiforme, Henoch-Schönlein purpura, idiopathic thrombocytopenia,meningococcemia, Kawasaki disease, and drug rash. We present 2 cases of acute hemorrhagic edema of infancy, discuss the characteristics of AHEI, and compare and contrast AHEI with similar dermatologic presentations. Read More

Int J Dermatol 2016 Apr 29;55(4):e198-203. Epub 2015 Dec 29.

Department of Dermatology, Federal University of São Paulo, São Paulo, Brazil.

Background: Adverse cutaneous drug reactions are frequent in hospital settings and are responsible for increased morbidity, mortality, and socioeconomic costs. The objective of this study was to identify high risk factors in hospitalized patients with adverse cutaneous drug reactions.

Methods: This descriptive and retrospective study was performed with data from 117 patients admitted to a quaternary hospital over 44 months. Read More

Eur J Intern Med 2016 Mar 7;28:17-24. Epub 2015 Dec 7.

Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Unità Operativa di Medicina Interna, IRCCS Fondazione Ca' Granda, Ospedale Maggiore Policlinico, Milano, Italy. Electronic address:

Cutaneous adverse drug reactions are frequent, affecting 2-3% of hospitalized patients and in one twentieth of them are potentially life-threatening. Almost any pharmacologic agent can induce skin reactions, and certain drug classes, such as non-steroidal anti-inflammatory drugs, antibiotics and antiepileptics, have drug eruption rates ranging from 1% to 5%. Cutaneous drug reactions recognize several different pathomechanisms: some skin manifestations are immune-mediated like allergic reactions while others are the result of non immunological causes such as cumulative toxicity, photosensitivity, interaction with other drugs or different metabolic pathways. Read More