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Adv Exp Med Biol 2022 ;1367:369-381

Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, Tainan, Taiwan.

Photodermatosis is an abnormal skin inflammatory reaction to light. The major classifications of photodermatoses are idiopathic photodermatoses, photodermatoses due to exogenous or endogenous agents, photo-exacerbated dermatoses, and photosensitive genodermatoses. In this chapter, we focus on idiopathic photodermatoses and drug-related photodermatoses and emphasize on the epidemiology and immunogenetic backgrounds. Read More

Arerugi 2021;70(10):1363-1370

Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine.

Exp Dermatol 2022 04 12;31(4):586-593. Epub 2021 Nov 12.

St. John's Institute of Dermatology, Guy's Hospital, London, UK.

Solar urticaria is a rare, immunologically mediated photodermatosis in which activation of cutaneous mast cells is triggered by specific wavelengths of solar electromagnetic radiation. This manifests clinically as the rapid development of cutaneous itch, erythema and wheal formation after several minutes of sun exposure. Disease mechanisms in solar urticaria remain incompletely elucidated and there have been few recent investigations of its pathobiology. Read More

Rev Alerg Mex 2021 Jul-Sep;68(3):214-217

Universidad de Antioquia, Facultad de Medicina, Grupo de Alergología Clínica y Experimental, Medellín, Colombia.

Introduction: In December 2019, a new coronavirus was identified as the causal agent of the 2019 coronavirus disease (COVID-19) with a wide clinical spectrum that goes from asymptomatic cases to critical and fatal cases. Its usual manifestations are fever, cough, and fatigue; although some cases present skin lesions.

Cases Report: The first case was a 30-year-old woman with a history of controlled solar urticaria who presented erythematous and pruritic wheals in malar and cervical regions and extremities; associated with general malaise, headaches, and nausea, in whom the presence of COVID-19 was confirmed; her condition improved with a quadruple dose of antihistamines. Read More

Ital J Pediatr 2021 Sep 28;47(1):195. Epub 2021 Sep 28.

Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", Allergy Unit, University of Messina, Via Consolare Valeria 1, 98124, Messina, ME, Italy.

Background: Solar urticaria represents an uncomfortable form of chronic inducible urticaria. First and second-line treatments are ineffective in some patients, leading to an impairment in their quality of life. Omalizumab represents a safe therapeutic option in case of refractory solar urticaria. Read More

Cureus 2021 Aug 6;13(8):e16950. Epub 2021 Aug 6.

Dermatology, San Diego Family Dermatology, National City, USA.

Urticaria is a common group of dermatologic disorders characterized by hives. Solar urticaria and heat urticaria are two rare types of chronic inducible urticarias. Solar urticaria is triggered by exposure to sunlight or ultraviolet radiation. Read More

Photodermatol Photoimmunol Photomed 2022 Mar 5;38(2):99-103. Epub 2021 Aug 5.

Dermatology, allergology and photobiology Department, Grenoble-Alpes University Hospital, Grenoble, France.

Background: Photodermatoses are sun-related inflammatory skin diseases. They usually require phototesting in diagnosis. However, fewer and fewer medical centers in France are equipped with photobiological equipment. Read More

J Clin Aesthet Dermatol 2021 Feb 1;14(2):50-60. Epub 2021 Feb 1.

Dr. Segars is with the Nova Southeastern University: College of Osteopathic Medicine and Largo Medical Center Department of Dermatology in Largo, Florida.

(PL) is a natural extract from tropical fern leaves with antioxidant and anti-inflammatory properties. It has been implicated as a potential treatment agent in multiple dermatologic conditions. Here, we review the mechanism of action and current dermatologic applications of PL and extrapolate potential future dermatologic applications of PL. Read More

Photodermatol Photoimmunol Photomed 2021 Sep 27;37(5):431-438. Epub 2021 Mar 27.

Photodermatosis Service, Division of Dermatology, Rabin Medical Center, Petah Tikva, Israel.

Solar urticaria is a well-recognized photodermatosis, sometimes accompanied by angioedema. However, isolated solar angioedema (ISA) is a rare and unrecognized entity. The purpose of our work was to systematically review the available data on ISA. Read More

J Drugs Dermatol 2021 03;20(3):290-294

Afamelanotide (SCENESSE®) is a synthetic analogue of α-melanocyte-stimulating hormone that is FDA-approved to increase pain-free sunlight exposure in adult patients with erythropoietic protoporphyria. Its dual photoprotective and anti-inflammatory effects also make it a promising therapy for other photosensitive dermatologic diseases that are resistant to treatment. The PubMed/MEDLINE and ClinicalTrials. Read More

J Dermatol 2021 Mar 2;48(3):385-388. Epub 2020 Dec 2.

Dermatology Hospital, Southern Medical University, Guangzhou, China.

Chronic actinic dermatitis (CAD) is a common debilitating photodermatosis. Patients often have to completely avoid outdoor activities, which severely impacts their quality of life. Phototherapy is effective for CAD and seems to increase patients' tolerance towards sunlight and consequently decrease the extent of disease. Read More

J Dtsch Dermatol Ges 2020 Nov;18(11):1261-1269

Zentrums für Dermatologie, HELIOS Universitätsklinikum Wuppertal, Universität Witten-Herdecke, Wuppertal.

Background And Objectives: Solar urticaria is a rare photodermatosis, yet lacking standardization in diagnosis and therapy. The aim of this research was to use innovative radiation sources for diagnostics with defines and reproducible emission spectrum and doses. A uniform therapy step scheme was to be created. Read More

Indian Dermatol Online J 2020 Sep-Oct;11(5):833-834. Epub 2020 Sep 19.

Department of Dermatology, All India Institute of Medical Sciences, Nagpur, Maharashtra, India.

J Dtsch Dermatol Ges 2020 Nov 16;18(11):1261-1268. Epub 2020 Nov 16.

Department of Dermatology, HELIOS University Hospital Wuppertal, University of Witten-Herdecke, Wuppertal, Germany.

Background And Objectives: Solar urticaria is a rare photodermatosis, the diagnosis and therapy of which have not yet been standardized. The aim of this research was to use innovative radiation sources for diagnostics with defined and reproducible emission spectra and doses. A uniform therapy step scheme was to be created. Read More

Acta Dermatovenerol Alp Pannonica Adriat 2020 Sep;29(3):141-148

Clinical Department of Dermatovenereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.

Chronic inducible urticaria (CIndU) is a common inflammatory skin condition characterized by the recurrence of itchy wheals and/or angioedema that lasts more than 6 weeks and is induced by specific physical or environmental stimuli (cold, heat, exercise, pressure, sunlight, vibration, water, etc.). According to the current international classification, it includes physical urticarias (dermographism, delayed-pressure urticaria, exercise-induced urticaria, cold urticaria, heat urticaria, solar urticaria, and vibratory urticaria) and non-physical urticarias caused by exposure to specific stimuli (cholinergic urticaria, contact urticaria, and aquagenic urticaria). Read More

Ned Tijdschr Tandheelkd 2020 Apr;127(4):237-243

The medicament afamelanotide is an analogue of endogenous ?-melanocyte-stimulating hormone. It promotes cutaneous pigmentation, providing protection from sunlight. In dermatology, afamelanotide seems to establish therapeutic results for polymorphic light eruption, solar urticaria, erythropoietic protoporphyria, Hailey-Hailey disease, vitiligo and acne vulgaris. Read More

Photodermatol Photoimmunol Photomed 2020 Sep 1;36(5):408-411. Epub 2020 Jun 1.

Dermatology Unit, University of Rome Tor Vergata, Rome, Italy.

J Allergy Clin Immunol Pract 2020 09 26;8(8):2817-2819.e1. Epub 2020 Apr 26.

Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kusunoki-cho, Chuo-ku, Kobe, Japan.

Isr Med Assoc J 2020 Apr;22(4):227-231

Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background: Solar urticaria (SU) is a rare and disabling photodermatosis. SU typically manifests as urticarial wheals and erythema appearing shortly after sun exposure. SU is often initially diagnosed clinically with subsequent confirmation through photoprovocation tests. Read More

Photodermatol Photoimmunol Photomed 2020 Sep 27;36(5):378-383. Epub 2020 Apr 27.

Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology Medicine and Health, Centre for Dermatology Research, School of Biological Sciences, University of Manchester, Manchester Academic Health Science Centre and Salford Royal NHS Foundation Trust, Manchester, UK.

Background: Cutaneous exposure to sunlight is a major source of vitamin D. Individuals with photosensitivity disorders have symptoms provoked by sunlight and may not achieve the brief sunlight exposures that convey vitamin D acquisition.

Objective: To explore knowledge, behaviour and attitudes towards vitamin D and its acquisition in patients with photosensitivity. Read More

Photodermatol Photoimmunol Photomed 2020 07 21;36(4):316-317. Epub 2020 Mar 21.

Department of Dermatology, Henry Ford Hospital, Detroit, Michigan.

Photodermatol Photoimmunol Photomed 2020 May 12;36(3):233-240. Epub 2020 Mar 12.

Department of Dermatology, Henry Ford Hospital, Detroit, Michigan.

Background: Previous studies at single academic institutions have identified variations in the prevalence of photodermatoses among racial groups. The purpose of the study was to compare the distribution of photodermatoses between Whites and Blacks at four academic medical centers in the USA.

Methods: A retrospective chart review was performed at four institutions' general dermatology clinics using diagnoses consistent with the International Classification of Disease (ICD), Ninth and Tenth Revisions, codes related to photodermatoses between August 2006 and August 2016. Read More

J Dermatol 2020 Apr 21;47(4):369-377. Epub 2020 Jan 21.

Department of Dermatology, Kansai Medical University, Osaka, Japan.

Solar urticaria has unique spectra, such as inhibition and augmentation. The clinical significance of these spectra, especially augmentation, is not well understood. Reported cases of solar urticaria with augmentation spectra are extremely rare in the published English-language work. Read More

Dermatol Clin 2020 Jan 18;38(1):71-77. Epub 2019 Oct 18.

Department of Dermatology, Henry Ford Health System, 3031 West Grand Boulevard, Suite 800, Detroit, MI 48202, USA. Electronic address:

Ultraviolet light (UV) and visible light are important components in the diagnosis of photodermatoses, and UV has the unique ability to also be used to manage photodermatoses. Phototesting, provocative light testing, and photopatch testing can provide important information in diagnosing patients with photodermatoses; phototesting can be used to determine the starting dose for phototherapy in these patients. Once photosensitivity is established, narrowband UVB and UVA1 therapy have helped to improve the quality of life of photosensitive patients, such as those with polymorphous light eruption, chronic actinic dermatitis, and solar urticaria. Read More

Cutis 2019 Jul;104(1):E4-E5

Allergy and Immunology Service, Tripler Army Medical Center, Honolulu, Hawaii, USA.

An Bras Dermatol 2019 07 29;94(3):331-333. Epub 2019 Jul 29.

Dermatology Department, Centro Hospitalar de Leiria, Leiria, Portugal.

Solar urticaria is a rare form of physical urticaria mediated by immunoglobulin E. The lesions appear immediately after the sun exposure, interfering with the patient's normal daily life. Omalizumab, a monoclonal anti-IgE antibody, has been recently approved for the treatment of chronic spontaneous urticaria, and the latest reports support its role also in the treatment of solar urticaria. Read More

Open Med (Wars) 2019 7;14:403-406. Epub 2019 Jun 7.

Department of Life, Health and Environmental Sciences, University of L'Aquila, Italy Allergy an Clinical Immunology Unit, AUSL 04 Teramo, Italy.

Solar urticaria is a rare type of photodermatosis that significantly reduces the quality of life of the subjects affected, with a risk of anaphylaxis should the entire body be exposed to the sun. Patients are forced to modify and limit their normal activities, and since the symptoms are triggered by exposure to sun, which is difficult if not impossible to avoid in everyday life, a safe and effective therapy appears to be essential. Unfortunately, traditional therapies in a discrete number of patients are unable to provide adequate and safe answers. Read More

J Am Acad Dermatol 2019 May 28. Epub 2019 May 28.

Dermatology Department, Photobiology Unit, Hospital Clínic de Barcelona, Universitat de Barcelona, Spain. Electronic address:

G Ital Dermatol Venereol 2020 Dec 29;155(6):800-802. Epub 2019 Mar 29.

Unit of Allergological and Occupational Dermatology, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.

Clin Exp Dermatol 2019 Jul 13;44(5):e164-e170. Epub 2019 Apr 13.

Photodermatosis Service, Department of Dermatology, Rabin Medical Center - Beilinson Hospital, Petach Tikva, Israel.

Background: Solar urticaria (SU) is a rare photodermatosis causing a significant impact on patients' quality of life (QoL), and treatment is often challenging.

Aim: To analyse clinical experience with a tailored stepwise therapeutic approach.

Methods: A retrospective cohort design was used. Read More