523 results match your criteria Urticaria Pressure


COVID-19 and dermatology.

Authors:
Ülker GÜl

Turk J Med Sci 2020 Jun 30. Epub 2020 Jun 30.

Sars-CoV-2 virus infection (COVID-19) was observed in China in the last months of 2019. In the following period, this infection spread all over the world. In March 2020, the World Health Organization announced the existence of a pandemic. Read More

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http://dx.doi.org/10.3906/sag-2005-182DOI Listing

Acquired angioedema induced by angiotensin-converting enzyme inhibitors - experience of a hospital-based allergy center.

Exp Ther Med 2020 Jul 27;20(1):68-72. Epub 2020 Jan 27.

Dermatology Research Laboratory, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Angiotensin-converting enzyme inhibitors (ACEIs) represent an important group of pharmacological compounds, largely prescribed for more than 30 years. They have been extensively evaluated in clinical trials, demonstrating significant reduction of morbidity and mortality of patients with cardiovascular diseases, mainly high blood pressure, myocardial infarction, heart failure and stroke. Besides their beneficial effects and a general good safety profile, it was proven that ACEIs might also induce adverse effects in some patients, most notably angioedema (AE) and chronic cough. Read More

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http://dx.doi.org/10.3892/etm.2020.8474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271703PMC

Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome.

Elife 2020 04 27;9. Epub 2020 Apr 27.

Intensive Care, Radboudumc Center for Infectious Diseases (RCI), Radboudumc, Nijmegen, Netherlands.

COVID-19 patients can present with pulmonary edema early in disease. We propose that this is due to a local vascular problem because of activation of bradykinin 1 receptor (B1R) and B2R on endothelial cells in the lungs. SARS-CoV-2 enters the cell via ACE2 that next to its role in RAAS is needed to inactivate des-Arg9 bradykinin, the potent ligand of the B1R. Read More

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http://dx.doi.org/10.7554/eLife.57555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213974PMC

Delayed Pressure Urticaria: A Systematic Review of Treatment Options.

J Allergy Clin Immunol Pract 2020 Jun 13;8(6):2035-2049.e5. Epub 2020 Mar 13.

Dermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany. Electronic address:

Background: Delayed pressure urticaria (DPU) is characterized by recurrent erythematous and often painful swelling after the skin is exposed to sustained pressure. Treatment is challenging. Antihistamines, the first-line and only approved treatment, are often not effective. Read More

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http://dx.doi.org/10.1016/j.jaip.2020.03.004DOI Listing

An Urticarial Primer.

S D Med 2019 Dec;72(12):556-560

Dakota Asthma and Allergy, Sioux Falls, South Dakota.

This primer focuses on the diagnosis and treatment of urticaria. All forms have in common the release of histamine with resultant pruritis. Causes include allergies, medications, infections, cold, heat, and pressure with many being defined as idiopathic. Read More

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December 2019

Recalcitrant, delayed pressure urticaria treated with long-term intravenous immunoglobulin.

JAAD Case Rep 2020 Mar 18;6(3):176-177. Epub 2020 Feb 18.

Department of Dermatology, Henry Ford Hospital, Detroit, Michigan.

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http://dx.doi.org/10.1016/j.jdcr.2019.01.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7029339PMC

Genetic susceptibility to angiotensin-converting enzyme-inhibitor induced angioedema: A systematic review and evaluation of methodological approaches.

PLoS One 2019 11;14(11):e0224858. Epub 2019 Nov 11.

Department of Oto-Rhino-Laryngology-Head and Neck Surgery and Audiology, Denmark.

Angiotensin-converting enzyme (ACE) converts angiotensin I to angiotensin II which causes vasoconstriction. ACE inhibitors reduce blood pressure by inhibiting ACE. A well-known adverse drug reaction to ACE inhibitors is ACE inhibitor-induced angioedema (ACEi-AE). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0224858PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6844479PMC

Urticaria and angioedema.

Allergy Asthma Proc 2019 11;40(6):437-440

Urticaria, also known as hives, may affect up to 20% of the population at some time. Urticaria is described as pruritic erythematous, raised, circumscribed lesions with central pallor that blanch with pressure. Urticaria is closely associated with angioedema in 40% of individuals; approximately 10% of patients experience angioedema without urticaria. Read More

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http://dx.doi.org/10.2500/aap.2019.40.4266DOI Listing
November 2019
1 Read

Orolingual Angioedema After Tissue Plasminogen Activator Administration in Patients Taking Angiotensin-Converting Enzyme Inhibitors.

Adv Emerg Nurs J 2019 Jul/Sep;41(3):204-214

Department of Pharmacy, University of Louisville Hospital, Kentucky.

Orolingual angioedema is a rare adverse effect (1%-5%) of tissue plasminogen activator (tPA) that can lead to significant morbidity in patients with acute ischemic stroke. It is thought that increased levels of bradykinin and histamine resulting from tPA administration can result in angioedema. Angiotensin-converting enzyme (ACE) inhibitors can also lead to increased levels of bradykinin and appear to be a risk factor for tPA-associated angioedema. Read More

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http://Insights.ovid.com/crossref?an=01261775-201907000-0000
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http://dx.doi.org/10.1097/TME.0000000000000250DOI Listing
January 2020
2 Reads

Treatment of urticaria: a clinical and mechanistic approach.

Authors:
Allen P Kaplan

Curr Opin Allergy Clin Immunol 2019 08;19(4):387-392

Department Medicine, The Medical University of South Carolina, Charleston, South Carolina, USA.

Purpose Of Review: This manuscript describes the recommended therapy of chronic spontaneous urticaria based on our understanding of the pathogenesis of hive formation. Thus, the mechanism of action of each medication is elaborated in addition to a discussion of clinical utility.

Recent Findings: The main drugs are antihistamines, omalizumab, and cyclosporine with a success rate of 40-55, 65-80, and 70-80%, respectively. Read More

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http://dx.doi.org/10.1097/ACI.0000000000000538DOI Listing
August 2019
12 Reads

Flow-mediated dilation shows impaired endothelial function in patients with mastocytosis.

J Allergy Clin Immunol 2019 10 15;144(4):1106-1111. Epub 2019 Jun 15.

Division of Allergy and Clinical Immunology, Department of Medicine, University of Salerno, Salerno, Italy. Electronic address:

Background: Mastocytosis is a rare disease characterized by clonal proliferation of mast cells (MCs) in different organs. Clinical manifestations of mastocytosis are mostly due to release of mediators from MCs and, in many cases, such as urticaria, flushing, angioedema, and anaphylaxis, are an expression of the biological effects of mediators on endothelial cells. Chronic secretion of mediators in patients with mastocytosis can lead to alteration of endothelial function. Read More

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http://dx.doi.org/10.1016/j.jaci.2019.05.037DOI Listing
October 2019
12 Reads

Angioedema in Stroke Patients With Thrombolysis.

Stroke 2019 07 11;50(7):1682-1687. Epub 2019 Jun 11.

From the Department of Neurology (K.F., K.M., S.T.G., T.B., M.J.H., S.S., F.S., B.K., K.W.), University Hospital Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Germany.

Background and Purpose- Oral angioedema (OA) is a rare but life-threatening complication in patients with ischemic stroke receiving intravenous thrombolysis with r-tPA (recombinant tissue-type plasminogen activator). This study intended to determine associations between thrombolysis-related OA and ischemic stroke lesion sites using a voxel-wise lesion analysis. Methods- Prospective registry data were used to identify ischemic stroke patients with thrombolysis-related OA between 2002 and 2018. Read More

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http://dx.doi.org/10.1161/STROKEAHA.119.025260DOI Listing
July 2019
3 Reads

An unexpected challenging airway: Urticaria factitia caused difficult mask ventilation and tracheal intubation.

J Clin Anesth 2019 Nov 10;57:116. Epub 2019 Apr 10.

Duzce University Faculty of Medicine, Neurosurgery Department, Duzce, Turkey.

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http://dx.doi.org/10.1016/j.jclinane.2019.04.002DOI Listing
November 2019
2 Reads

[Anaphylactic shock secondary to the use of macrogol 4000 as a bowel cleanser:a case report].

Nihon Shokakibyo Gakkai Zasshi 2019 ;116(4):330-335

Department of Gastroenterology and Hepatology, Itami City Hospital.

A 44-year-old man was administered Niflec containing macrogol 4000 as a bowel cleanser for colonoscopic examination. Immediately after ingestion, he experienced oral cavity discomfort and nasal congestion, followed by acute urticaria and presyncope. His systolic blood pressure and peripheral capillary oxygen saturation dropped to 66mmHg and 89%, respectively. Read More

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http://dx.doi.org/10.11405/nisshoshi.116.330DOI Listing
July 2019
10 Reads

Sexual intercourse as a trigger of inducible urticaria.

Authors:
Mario Geller

Ann Allergy Asthma Immunol 2019 06 20;122(6):659-660. Epub 2019 Mar 20.

Geller Allergy and Immunology Clinic, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2019.03.012DOI Listing
June 2019
2 Reads

Opioid Free Anesthesia for Laparotomic Hemicolectomy: A Case Report.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Dec;39(2-3):121-126

University Clinic for Thoracic and Vascular Surgery, Medical Faculty, University "Ss. Cyril and Methodius" Skopje, Republic of Macedonia.

Opioid free anesthesia (OFA) is deffined as anaesthesiological technique where opioids are not used in the intraoperative period (systemic, neuroaxial or intracavitary). Anaphylaxis caused by opioids (fentanyl) is very rare, and the reaction is presented with hypotension and urticaria. When we have proven allergy to fentanyl, patients' refusal of placing epidural catheter and refusal of receiving bilateral ultrasound guided transversus abdominis plane block (USG TAPB), we must think of using multimodal nonopioide analgesia. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0050DOI Listing
December 2018
12 Reads

Omalizumab in Chronic Urticaria: An Italian Survey.

Int Arch Allergy Immunol 2019;178(1):45-49. Epub 2018 Nov 5.

Clinical Dermatology, IRCCS Istituto Ortopedico Galeazzi, Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.

Omalizumab is approved for use in chronic spontaneous urticaria (CSU); however, it is not approved for chronic inducible urticaria (CIndU). The aim of the present study was to assess the effectiveness of omalizumab in treating CSU and CIndU in Italy. This is a multicentre prospective observational real-life study involving patients with severe urticaria capable of undergoing omalizumab therapy. Read More

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https://www.karger.com/Article/FullText/492532
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http://dx.doi.org/10.1159/000492532DOI Listing
April 2019
47 Reads

Novel, efficient, facile, and comprehensive protocol for post-column amino acid analysis of icatibant acetate containing natural and unnatural amino acids using the QbD approach.

Amino Acids 2019 Feb 16;51(2):295-309. Epub 2018 Oct 16.

Jawaharlal Nehru Technological University, Kukatpally, Hyderabad, 500085, India.

Qualitative and quantitative determination of amino acid composition using amino acid analysis (AAA) is an important quality attribute and considered an identity of therapeutic peptide drugs by the regulatory agencies. Although huge literature is available on pre- and post- column derivatization AAA methods, arriving at an appropriate hydrolysis protocol coupled with adequate separation of the derivatized/underivatized amino acids is always challenging. Towards achieving a facile and comprehensive protocol for AAA, the present work is geared towards developing a deeper understanding of the extent of hydrolysis of peptide, and the nature and stability of amino acids present in the peptide backbone. Read More

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http://link.springer.com/10.1007/s00726-018-2665-9
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http://dx.doi.org/10.1007/s00726-018-2665-9DOI Listing
February 2019
167 Reads

Delayed bullous pressure urticaria: the puzzling role of eosinophils.

J Dtsch Dermatol Ges 2018 Oct;16(10):1253-1255

Klinikum rechts der Isar, Technical University of Munich (TUM), Department of Dermatology and Allergy Biederstein, Munich, Germany.

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http://dx.doi.org/10.1111/ddg.13644DOI Listing
October 2018
11 Reads

Delayed pressure urticaria due to non-invasive blood pressure monitoring in a previously non-atopic man.

BMJ Case Rep 2018 Sep 15;2018. Epub 2018 Sep 15.

Department of Urology, King George's Medical University, Lucknow, Uttar Pradesh, India.

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http://dx.doi.org/10.1136/bcr-2018-227267DOI Listing
September 2018
38 Reads

How to Approach Chronic Inducible Urticaria.

J Allergy Clin Immunol Pract 2018 Jul - Aug;6(4):1119-1130

Division of Allergy and Immunology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Tex.

Chronic inducible urticaria (CIndU) is a group of chronic urticarias characterized by the appearance of recurrent wheals, recurrent angioedema or both, as a response to specific triggers. CIndU includes both physical (symptomatic dermographism, cold and heat urticaria, delayed pressure urticaria, solar urticaria, and vibratory urticaria) and nonphysical urticarias (cholinergic urticaria, contact and aquagenic urticaria). Here, we review the different forms of CIndU with an emphasis on symptomatic dermographism, cold urticaria, cholinergic urticaria, and delayed pressure urticaria. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.03.007DOI Listing
October 2019
91 Reads

Diagnosis, pathogenesis, and treatment of chronic spontaneous urticaria.

Authors:
Allen P Kaplan

Allergy Asthma Proc 2018 May;39(3):184-190

Background: Chronic Spontaneous Urticaria (CSU) is an endogenous disorder that is strongly associated with autoimmunity, particularly with immunoglobulin G (IgG) antibody to the alpha subunit of the IgE receptor seen in 35-40% of patients. Basophils and cutaneous mast cells can be activated and lead to a late-phase-like perivascular infiltration about small venules and hive formation.

Methods: Review of current literature. Read More

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http://dx.doi.org/10.2500/aap.2018.39.4121DOI Listing
May 2018
14 Reads

Management of anaphylaxis in Spain: pediatric emergency care providers' knowledge.

Eur J Emerg Med 2019 Jun;26(3):163-167

Department of Pediatric Emergency, Cruces University Hospital - Basque Country University.

Background: Acute care providers must diagnose and treat patients with anaphylaxis. The objective was to analyze Spanish pediatric emergency departments' (ED) providers' knowledge of the international recommendations for the management of anaphylaxis.

Methods: A web-based survey including providers (both attending and residents) from seven Spanish pediatric EDs was conducted. Read More

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http://dx.doi.org/10.1097/MEJ.0000000000000515DOI Listing
June 2019
37 Reads

Angiotensin-Converting Enzyme Inhibitors in Hypertension: To Use or Not to Use?

J Am Coll Cardiol 2018 04;71(13):1474-1482

Department of Cardiology and Clinical Research, University Hospital, Bern, Switzerland.

Most guidelines for the management of patients with cardiovascular disease recommend angiotensin-converting enzyme (ACE) inhibitors as first-choice therapy, whereas angiotensin receptor blockers (ARBs) are merely considered an alternative for ACE inhibitor-intolerant patients. The aim of this review was to compare outcomes and adverse events between ACE inhibitors and ARBs in patients. In patients with hypertension and hypertension with compelling indications, we found no difference in efficacy between ARBs and ACE inhibitors with regard to the surrogate endpoint of blood pressure and outcomes of all-cause mortality, cardiovascular mortality, myocardial infarction, heart failure, stroke, and end-stage renal disease. Read More

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http://dx.doi.org/10.1016/j.jacc.2018.01.058DOI Listing
April 2018
15 Reads

Chronic inducible urticaria: A systematic review of treatment options.

J Allergy Clin Immunol 2018 05 10;141(5):1726-1734. Epub 2018 Feb 10.

Department of Dermatology, Venerology and Allergy, Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. Electronic address:

Background: Chronic inducible urticaria (CindU) is a condition characterized by the appearance of recurrent wheals, angioedema, or both as a response to specific and reproducible triggers.

Objective: We sought to systematically assess evidence on the efficacy and safety of treatment options for CindU. Results were used to inform the 2017 update of "The EAACI/GALEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183022
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http://dx.doi.org/10.1016/j.jaci.2018.01.031DOI Listing
May 2018
67 Reads

A Case of Intraoperative Anaphylaxis Caused by Bovine-Derived Thrombin.

Allergy Asthma Immunol Res 2018 Mar;10(2):184-186

Division of Allergy and Immunology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Intraoperative bovine-derived topical thrombin is still widely used for hemostasis during surgery. A 38-year-old woman with chronic spontaneous urticaria was referred to the orthopedic surgery department for herniated disk and myelopathy. During the first stage of operation, bovine-derived thrombin powder soaked in Gelfoam was used as a hemostatic aid. Read More

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http://dx.doi.org/10.4168/aair.2018.10.2.184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809769PMC
March 2018
13 Reads

Cause and Clinical Presentation of Anaphylaxis in Singapore: From Infancy to Old Age.

Int Arch Allergy Immunol 2018 5;175(1-2):91-98. Epub 2018 Jan 5.

Department of Allergy and Immunology, KK Women's and Children's Hospital, Singapore, Singapore.

Background: The study objective was to compare age-related differences in the cause and clinical presentation of anaphylaxis.

Methods: We conducted a prospective study of patients visiting the emergency department for anaphylaxis. Data were collected from 3 emergency departments from 1 April 2014 to 31 December 2015. Read More

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http://dx.doi.org/10.1159/000485127DOI Listing
April 2018
84 Reads

Rational ideation and empiric validation of an innovative digital dermographic tester.

Clin Exp Dermatol 2018 Apr 22;43(3):268-273. Epub 2017 Dec 22.

Department of Medicine, Surgery and Odontology Scuola Medica Salernitana, University of Salerno, Salerno, Italy.

Background: Dermographism is a condition characterized by a weal response to a combination of pressure and traction on skin surface, and its diagnosis is based on medical history, clinical criteria and provocation test. The Dermographic Tester , a pen-sized tool containing a spring-loaded blunt tip, is the most widely used instrument for the provocation test, and it exerts increasing pressures on the skin surface according to an arbitrary units (AU) scale. Analysing the mechanism of function and trying to convert the AUs to SI units (g/mm ), we found that this instrument had some defects and limits that would compromise a true and repeatable quantification of the weal response threshold. Read More

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http://dx.doi.org/10.1111/ced.13314DOI Listing
April 2018
21 Reads

Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone.

Int J Dermatol 2018 Jan 12;57(1):104-109. Epub 2017 Dec 12.

Epworth Hospital, East Melbourne, Vic., Australia.

Background: Minoxidil and spironolactone are oral antihypertensives known to stimulate hair growth.

Objective: To report on a case series of women with pattern hair loss (PHL) treated with once daily minoxidil 0.25 mg and spironolactone 25 mg. Read More

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http://doi.wiley.com/10.1111/ijd.13838
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http://dx.doi.org/10.1111/ijd.13838DOI Listing
January 2018
23 Reads

Hereditary angioedema: Assessing the hypothesis for underlying autonomic dysfunction.

PLoS One 2017 6;12(11):e0187110. Epub 2017 Nov 6.

Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.

Background: Attacks of Hereditary Angioedema due to C1-inhibitor deficiency (C1-INH-HAE)are often triggered by stressful events/hormonal changes.

Objective: Our study evaluates the relationship between autonomic nervous system (ANS) and contact/complement system activation.

Methods: Twenty-three HAE patients (6 males, mean age 47. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187110PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5673184PMC
November 2017
36 Reads

The Risks and Benefits of Cannabis in the Dermatology Clinic.

J Cutan Med Surg 2018 Mar/Apr;22(2):194-199. Epub 2017 Oct 23.

2 Division of Dermatology, Department of Medicine, Queen's University, Kingston, ON, Canada.

Cannabis ( Cannabis sativa/indica), also known as marijuana, has been used for medicinal and recreational purposes for millennia. There has been a recent trend to legalize the use of cannabis, as illustrated by the recent legalization votes in numerous states in the United States and legislation in Canada to allow recreational cannabis use. With this increasing consumption of cannabis, dermatologists will see increased pressure to prescribe cannabis and will see the side effects of cannabis use with greater frequency. Read More

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http://dx.doi.org/10.1177/1203475417738971DOI Listing
September 2018
27 Reads

Chronic Spontaneous Urticaria: Pathogenesis and Treatment Considerations.

Authors:
Allen P Kaplan

Allergy Asthma Immunol Res 2017 Nov;9(6):477-482

Department of Medicine, Division of Pulmonary and Critical Care Medicine, Allergy and Clinical Immunology, Medical University of South Carolina, Charleston, SC, USA.

The treatment of chronic spontaneous urticaria begins with antihistamines; however, the dose required typically exceeds that recommended for allergic rhinitis. Second-generation, relatively non-sedating H₁-receptor blockers are typically employed up to 4 times a day. First-generation antihistamines, such as hydroxyzine or diphenhydramine (Atarax or Benadryl), were employed similarly in the past. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.4168/aair.2017.9
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http://dx.doi.org/10.4168/aair.2017.9.6.477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603475PMC
November 2017
20 Reads

Omalizumab treatment in patients with chronic inducible urticaria: A systematic review of published evidence.

J Allergy Clin Immunol 2018 02 24;141(2):638-649. Epub 2017 Jul 24.

Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Background: Omalizumab, a recombinant anti-IgE antibody, effectively treats chronic spontaneous urticaria. Evidence is lacking in patients with chronic inducible urticarias (CIndUs), which are frequently H-antihistamine resistant.

Objective: From the current published literature, we aimed to determine the strength of evidence for omalizumab efficacy and safety in the treatment of CIndUs. Read More

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http://dx.doi.org/10.1016/j.jaci.2017.06.032DOI Listing
February 2018
53 Reads

Management of persistent lingual angioedema: a team approach.

Authors:
Ralph H Saunders

Gen Dent 2017 Jul-Aug;65(4):60-62

A 70-year-old African American man suffered anoxic encephalopathy following a choking episode. He had a history of hypertension, which was being treated with lisinopril, an angiotensin-converting enzyme inhibitor (ACEI). Soon after the patient's admission to an intensive care unit, his tongue began to swell until it reached more than twice its normal size and extended almost 2 inches outside his mouth. Read More

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May 2018
7 Reads

Pharmacokinetic, pharmacodynamic, and antihypertensive effects of the neprilysin inhibitor LCZ-696: sacubitril/valsartan.

J Am Soc Hypertens 2017 Jul 25;11(7):461-468. Epub 2017 May 25.

Department of Cardiology, University of Oklahoma College of Medicine, Oklahoma City, OK, USA. Electronic address:

LCZ-696, sacubitril/valsartan, is a dual-acting molecule consisting of the angiotensin II (Ang II) receptor blocker valsartan and the neprilysin (neutral endopeptidase) inhibitor AHU-377 with significant beneficial effects in patients with hypertension and heart failure (HF). Several recent studies have demonstrated a higher effectiveness of LCZ-696 compared to valsartan in the treatment of hypertension and HF. The rationale for the development and the Food and Drug Administration approval of LCZ-696 was based on the concept of an additive effect of the Ang II receptor blocker valsartan and the neutral endopeptidase (neprilysin) inhibitor AHU-377 for the treatment of hypertension and HF. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19331711173014
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http://dx.doi.org/10.1016/j.jash.2017.04.012DOI Listing
July 2017
15 Reads

Long-term management of chronic spontaneous urticaria with omalizumab.

Clin Exp Dermatol 2017 Oct 25;42(7):735-742. Epub 2017 Jun 25.

Dermatology Department, Coimbra University Hospital Centre, Coimbra, Portugal.

Background: Clinical trials have shown the efficacy of omalizumabs efficacy in refractory chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU), but real-life management strategies are lacking.

Aim: To assess the long-term efficacy and safety of omalizumab, and to identify predictive factors and optimum dosage regimens.

Methods: This was a prospective study of 13 patients (11 women, 2 men) with severe CSU [weekly urticaria activity score (UAS7) > 28] resistant to anti-H1 antihistamines. Read More

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http://dx.doi.org/10.1111/ced.13173DOI Listing
October 2017
47 Reads

Review of Physical Urticarias and Testing Methods.

Curr Allergy Asthma Rep 2017 Aug;17(8):51

Allergy and Clinical Immunology Department, Centro Médico Docente La Trinidad, Caracas, Venezuela.

Purpose Of Review: This review aims to update the information available on the prevalence, clinical picture, diagnostic methods, and treatment of urticarias induced by external physical stimuli.

Recent Findings: Physical urticarias are present in up to 5% of the general population, and in 10 to 50% of patients with chronic urticaria. Recent investigations have provided evidence that the presence of physical urticaria alone or when comorbid with chronic spontaneous urticaria is associated with a worse prognosis and duration. Read More

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http://dx.doi.org/10.1007/s11882-017-0722-1DOI Listing
August 2017
21 Reads

Diagnostic properties of provocation tests for cold, heat, and delayed-pressure urticaria.

Eur J Dermatol 2017 08;27(4):406-408

Department of Dermato-Venereology, Bispebjerg Hospital, University of Copenhagen, Denmark, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

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http://dx.doi.org/10.1684/ejd.2017.3014DOI Listing
August 2017
32 Reads

Anaphylaxis following intralesional triamcinolone acetonide (Kenacort) injection.

Asia Pac Allergy 2017 Apr 6;7(2):115-118. Epub 2017 Apr 6.

Division of Allergy, Immunology and Rheumatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.

Intralesional triamcinolone acetonide injection is indicated for multiple skin conditions such as keloid scars, alopecia areata, and hypertrophic lichen planus. Immediate hypersensitivity reaction remains uncommon. We report on a 24-year-old woman who had received multiple intralesional injections with triamcinolone acetonide (Kenacort) plus lidocaine for keloid scar treatment without any reaction for the previous 10 years. Read More

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http://dx.doi.org/10.5415/apallergy.2017.7.2.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410410PMC
April 2017
68 Reads

[Anesthetic management of late pressure angioedema].

Rev Bras Anestesiol 2017 Jul - Aug;67(4):422-425. Epub 2017 Apr 22.

Hospital Garcia de Orta, Departamento de Anestesiologia, Almada, Portugal.

Background And Objectives: Late pressure angioedema is a rare form of angioedema in which light pressure stimulus can lead to edema after 1-12h. This uncommon and unreported entity is especially important in patients who undergo general anesthesia, for whom the usual harmless supine position, intravenous catheter insertion, standard monitoring, airway management and ventilation can lead to life threatening consequences as the trigger is a physical stimulus.

Case Report: In this report, we describe a successful perioperative anesthetic management of a 30 year old patient, proposed for intra-ocular lens insertion, with a severe form of the disease with peri-oral, tongue and limb edema presentation. Read More

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http://dx.doi.org/10.1016/j.bjan.2017.03.005DOI Listing
May 2019
14 Reads

Follicular traction urticaria.

An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):64-65

Okmeydani Training and Research Hospital - Istanbul, Turkey.

Inducible urticaria is a heterogeneous subgroup of chronic urticarias caused by a wide variety of environmental stimuli, such as exercise, cold, heat, pressure, sunlight, vibration, and water. A new term, follicular traction urticaria, was suggested as an unusual form of inducible urticarias. We report a patient who was diagnosed with follicular traction urticaria. Read More

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
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http://dx.doi.org/10.1590/abd1806-4841.20164654DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324996PMC
July 2017
62 Reads

Delayed effort-induced swelling with myofasciitis and systemic manifestations: A so far unrecognized type of pressure-induced urticaria.

Medicine (Baltimore) 2017 Feb;96(7):e6112

Department of Dermatology, University Hospital of Strasbourg, Strasbourg, France.

Diseases characterized by recurrent symptoms with prolonged intervals without any clinical manifestations can pose diagnostic difficulties. Some diagnoses will be obvious but other situations can be very challenging.To nosologically delineate a new entity characterized by recurrent flares of induration of the forearms and legs with swelling of the extremities accompanied by intense fatigue and variable other symptoms. Read More

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http://dx.doi.org/10.1097/MD.0000000000006112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319520PMC
February 2017
36 Reads

Cutaneous exposure to vesicant phosgene oxime: Acute effects on the skin and systemic toxicity.

Toxicol Appl Pharmacol 2017 02 11;317:25-32. Epub 2017 Jan 11.

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

Phosgene Oxime (CX), an urticant or nettle agent categorized as a vesicant, is a potential chemical warfare and terrorist weapon. Its exposure can result in widespread and devastating effects including high mortality due to its fast penetration and ability to cause immediate severe cutaneous injury. It is one of the least studied chemical warfare agents with no effective therapy available. Read More

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http://dx.doi.org/10.1016/j.taap.2017.01.003DOI Listing
February 2017
25 Reads
3.705 Impact Factor

Re-exposure to low osmolar iodinated contrast media in patients with prior moderate-to-severe hypersensitivity reactions: A multicentre retrospective cohort study.

Eur Radiol 2017 Jul 14;27(7):2886-2893. Epub 2016 Dec 14.

Division of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Objectives: To evaluate the outcomes of re-exposure to low-osmolar iodinated contrast medium (LOCM) in patients with a history of moderate-to-severe hypersensitivity reaction (HSR).

Methods: We retrospectively evaluated a cohort comprising all subjects satisfying the following conditions at 11 centres: (1) experienced a moderate-to-severe HSR to LOCM by December 2014, and (2) underwent contrast-enhanced computed tomography after the initial HSR between January 2014 and December 2014.

Results: A total of 150 patients with 328 instances of re-exposure were included; the recurrence rate of HSR was 19. Read More

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http://dx.doi.org/10.1007/s00330-016-4682-yDOI Listing
July 2017
53 Reads
4.010 Impact Factor

Acrally distributed dermatoses: Vascular dermatoses (purpura and vasculitis).

Clin Dermatol 2017 Jan - Feb;35(1):68-80. Epub 2016 Sep 10.

Department of Dermatology and Venereology, Tokuda Hospital Sofia, Sofia, Bulgaria.

Purpuric lesions appear in acral distribution in a variety of conditions and often provide clues to the clinical diagnosis. Purpuric means "hemorrhagic"-that is, the lesions do not blanch from pressure. This review focuses on dermatoses that produce hemorrhagic lesions in acral distribution from the large groups of the vasculitic diseases and their mimics. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2016.09.013DOI Listing
June 2017
55 Reads

Prevalence of Inducible Urticaria in Patients with Chronic Spontaneous Urticaria: Associated Risk Factors.

J Allergy Clin Immunol Pract 2017 Mar - Apr;5(2):464-470. Epub 2016 Nov 9.

Group of Experimental and Clinical Allergy, IPS Universitaria, University of Antioquia, Medellín, Colombia.

Background: Information on the prevalence of inducible urticaria (IU) in patients with chronic spontaneous urticaria (CSU) and the factors affecting this prevalence is scarce in the literature.

Objectives: To estimate the frequency of IU in patients with CSU and to explore possible factors associated with CSU.

Methods: Patients older than 12 years diagnosed with CSU and a control group with no history of urticaria were recruited from 2 different cities. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22132198163047
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http://dx.doi.org/10.1016/j.jaip.2016.09.029DOI Listing
November 2017
29 Reads

Hereditary angioedema with F12 mutation: Clinical features and enzyme polymorphisms in 9 Southwestern Spanish families.

Ann Allergy Asthma Immunol 2016 11 24;117(5):520-526. Epub 2016 Oct 24.

Immunology Department, Virgen del Rocío University Hospital, Seville, Spain.

Background: Information on F12 mutation hereditary angioedema (HAE) is still limited, but Spain is now recognized as having one of the highest concentrations of cases in Western Europe.

Objective: To describe unique features of HAE in Spanish carriers of the F12 mutation and investigate a potential role for angiotensin-converting enzyme (ACE) and aminopeptidase-P polymorphisms in disease expression.

Methods: This was a prospective observational cohort study of 35 individuals (80% females) from 9 unrelated families carrying the p. Read More

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http://dx.doi.org/10.1016/j.anai.2016.09.001DOI Listing
November 2016
19 Reads

Comprehensive technical and patient-care optimization in the management of pediatric apheresis for peripheral blood stem cell harvesting.

Transfus Apher Sci 2016 Dec 30;55(3):338-343. Epub 2016 Sep 30.

Department of Pediatric Oncology, Fukushima Medical University, Fukushima, Japan.

Background: Pediatric apheresis for peripheral blood stem cell transplantation should be carried out with due concern for low corporeal blood volume and vulnerability to hypocalcemia-related complications, hypovolemic shock, and hypervolemic cardiac overload.

Study Design And Methods: We retrospectively investigated a total of 267 apheresis procedures from 1990 to 2013 on 93 children between 0 and 10 years old, including 89 patients and 4 healthy donors, with body weights of 6.3 to 44. Read More

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http://dx.doi.org/10.1016/j.transci.2016.09.014DOI Listing
December 2016
59 Reads