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    Diagnosis, pathogenesis, and treatment of chronic spontaneous urticaria.
    Allergy Asthma Proc 2018 May;39(3):184-190
    Background: Chronic Spontaneous Urticaria (CSU) is an endogenous disorder that is strongly associated with autoimmunity, particularly with immunoglobulin G (IgG) antibody to the alpha subunit of the IgE receptor seen in 35-40% of patients. Basophils and cutaneous mast cells can be activated and lead to a late-phase-like perivascular infiltration about small venules and hive formation.

    Methods: Review of current literature. Read More

    Management of anaphylaxis in Spain: pediatric emergency care providers' knowledge.
    Eur J Emerg Med 2018 Apr 4. Epub 2018 Apr 4.
    Department of Pediatric Emergency, Cruces University Hospital - Basque Country University.
    Background: Acute care providers must diagnose and treat patients with anaphylaxis. The objective was to analyze Spanish pediatric emergency departments' (ED) providers' knowledge of the international recommendations for the management of anaphylaxis.

    Methods: A web-based survey including providers (both attending and residents) from seven Spanish pediatric EDs was conducted. Read More

    Chronic inducible urticaria: A systematic review of treatment options.
    J Allergy Clin Immunol 2018 Feb 10. Epub 2018 Feb 10.
    Department of Dermatology, Venerology and Allergy, Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. Electronic address:
    Background: Chronic inducible urticaria (CindU) is a condition characterized by the appearance of recurrent wheals, angioedema, or both as a response to specific and reproducible triggers.

    Objective: We sought to systematically assess evidence on the efficacy and safety of treatment options for CindU. Results were used to inform the 2017 update of "The EAACI/GALEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria. Read More

    A Case of Intraoperative Anaphylaxis Caused by Bovine-Derived Thrombin.
    Allergy Asthma Immunol Res 2018 Mar;10(2):184-186
    Division of Allergy and Immunology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
    Intraoperative bovine-derived topical thrombin is still widely used for hemostasis during surgery. A 38-year-old woman with chronic spontaneous urticaria was referred to the orthopedic surgery department for herniated disk and myelopathy. During the first stage of operation, bovine-derived thrombin powder soaked in Gelfoam was used as a hemostatic aid. Read More

    Cause and Clinical Presentation of Anaphylaxis in Singapore: From Infancy to Old Age.
    Int Arch Allergy Immunol 2018 5;175(1-2):91-98. Epub 2018 Jan 5.
    Department of Allergy and Immunology, KK Women's and Children's Hospital, Singapore, Singapore.
    Background: The study objective was to compare age-related differences in the cause and clinical presentation of anaphylaxis.

    Methods: We conducted a prospective study of patients visiting the emergency department for anaphylaxis. Data were collected from 3 emergency departments from 1 April 2014 to 31 December 2015. Read More

    Rational ideation and empiric validation of an innovative digital dermographic tester.
    Clin Exp Dermatol 2018 Apr 22;43(3):268-273. Epub 2017 Dec 22.
    Department of Medicine, Surgery and Odontology Scuola Medica Salernitana, University of Salerno, Salerno, Italy.
    Background: Dermographism is a condition characterized by a weal response to a combination of pressure and traction on skin surface, and its diagnosis is based on medical history, clinical criteria and provocation test. The Dermographic Tester , a pen-sized tool containing a spring-loaded blunt tip, is the most widely used instrument for the provocation test, and it exerts increasing pressures on the skin surface according to an arbitrary units (AU) scale. Analysing the mechanism of function and trying to convert the AUs to SI units (g/mm ), we found that this instrument had some defects and limits that would compromise a true and repeatable quantification of the weal response threshold. Read More

    Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone.
    Int J Dermatol 2018 Jan 12;57(1):104-109. Epub 2017 Dec 12.
    Epworth Hospital, East Melbourne, Vic., Australia.
    Background: Minoxidil and spironolactone are oral antihypertensives known to stimulate hair growth.

    Objective: To report on a case series of women with pattern hair loss (PHL) treated with once daily minoxidil 0.25 mg and spironolactone 25 mg. Read More

    Hereditary angioedema: Assessing the hypothesis for underlying autonomic dysfunction.
    PLoS One 2017 6;12(11):e0187110. Epub 2017 Nov 6.
    Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.
    Background: Attacks of Hereditary Angioedema due to C1-inhibitor deficiency (C1-INH-HAE)are often triggered by stressful events/hormonal changes.

    Objective: Our study evaluates the relationship between autonomic nervous system (ANS) and contact/complement system activation.

    Methods: Twenty-three HAE patients (6 males, mean age 47. Read More

    The Risks and Benefits of Cannabis in the Dermatology Clinic.
    J Cutan Med Surg 2018 Mar/Apr;22(2):194-199. Epub 2017 Oct 23.
    2 Division of Dermatology, Department of Medicine, Queen's University, Kingston, ON, Canada.
    Cannabis ( Cannabis sativa/indica), also known as marijuana, has been used for medicinal and recreational purposes for millennia. There has been a recent trend to legalize the use of cannabis, as illustrated by the recent legalization votes in numerous states in the United States and legislation in Canada to allow recreational cannabis use. With this increasing consumption of cannabis, dermatologists will see increased pressure to prescribe cannabis and will see the side effects of cannabis use with greater frequency. Read More

    Chronic Spontaneous Urticaria: Pathogenesis and Treatment Considerations.
    Allergy Asthma Immunol Res 2017 Nov;9(6):477-482
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Allergy and Clinical Immunology, Medical University of South Carolina, Charleston, SC, USA.
    The treatment of chronic spontaneous urticaria begins with antihistamines; however, the dose required typically exceeds that recommended for allergic rhinitis. Second-generation, relatively non-sedating H₁-receptor blockers are typically employed up to 4 times a day. First-generation antihistamines, such as hydroxyzine or diphenhydramine (Atarax or Benadryl), were employed similarly in the past. Read More

    Omalizumab treatment in patients with chronic inducible urticaria: A systematic review of published evidence.
    J Allergy Clin Immunol 2018 Feb 24;141(2):638-649. Epub 2017 Jul 24.
    Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
    Background: Omalizumab, a recombinant anti-IgE antibody, effectively treats chronic spontaneous urticaria. Evidence is lacking in patients with chronic inducible urticarias (CIndUs), which are frequently H-antihistamine resistant.

    Objective: From the current published literature, we aimed to determine the strength of evidence for omalizumab efficacy and safety in the treatment of CIndUs. Read More

    Long-term management of chronic spontaneous urticaria with omalizumab.
    Clin Exp Dermatol 2017 Oct 25;42(7):735-742. Epub 2017 Jun 25.
    Dermatology Department, Coimbra University Hospital Centre, Coimbra, Portugal.
    Background: Clinical trials have shown the efficacy of omalizumabs efficacy in refractory chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU), but real-life management strategies are lacking.

    Aim: To assess the long-term efficacy and safety of omalizumab, and to identify predictive factors and optimum dosage regimens.

    Methods: This was a prospective study of 13 patients (11 women, 2 men) with severe CSU [weekly urticaria activity score (UAS7) > 28] resistant to anti-H1 antihistamines. Read More

    Review of Physical Urticarias and Testing Methods.
    Curr Allergy Asthma Rep 2017 Aug;17(8):51
    Allergy and Clinical Immunology Department, Centro Médico Docente La Trinidad, Caracas, Venezuela.
    Purpose Of Review: This review aims to update the information available on the prevalence, clinical picture, diagnostic methods, and treatment of urticarias induced by external physical stimuli.

    Recent Findings: Physical urticarias are present in up to 5% of the general population, and in 10 to 50% of patients with chronic urticaria. Recent investigations have provided evidence that the presence of physical urticaria alone or when comorbid with chronic spontaneous urticaria is associated with a worse prognosis and duration. Read More

    Anaphylaxis following intralesional triamcinolone acetonide (Kenacort) injection.
    Asia Pac Allergy 2017 Apr 6;7(2):115-118. Epub 2017 Apr 6.
    Division of Allergy, Immunology and Rheumatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
    Intralesional triamcinolone acetonide injection is indicated for multiple skin conditions such as keloid scars, alopecia areata, and hypertrophic lichen planus. Immediate hypersensitivity reaction remains uncommon. We report on a 24-year-old woman who had received multiple intralesional injections with triamcinolone acetonide (Kenacort) plus lidocaine for keloid scar treatment without any reaction for the previous 10 years. Read More

    Follicular traction urticaria.
    An Bras Dermatol 2016 Sep-Oct;91(5 suppl 1):64-65
    Okmeydani Training and Research Hospital - Istanbul, Turkey.
    Inducible urticaria is a heterogeneous subgroup of chronic urticarias caused by a wide variety of environmental stimuli, such as exercise, cold, heat, pressure, sunlight, vibration, and water. A new term, follicular traction urticaria, was suggested as an unusual form of inducible urticarias. We report a patient who was diagnosed with follicular traction urticaria. Read More

    Delayed effort-induced swelling with myofasciitis and systemic manifestations: A so far unrecognized type of pressure-induced urticaria.
    Medicine (Baltimore) 2017 Feb;96(7):e6112
    Department of Dermatology, University Hospital of Strasbourg, Strasbourg, France.
    Diseases characterized by recurrent symptoms with prolonged intervals without any clinical manifestations can pose diagnostic difficulties. Some diagnoses will be obvious but other situations can be very challenging.To nosologically delineate a new entity characterized by recurrent flares of induration of the forearms and legs with swelling of the extremities accompanied by intense fatigue and variable other symptoms. Read More

    Cutaneous exposure to vesicant phosgene oxime: Acute effects on the skin and systemic toxicity.
    Toxicol Appl Pharmacol 2017 02 11;317:25-32. Epub 2017 Jan 11.
    Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
    Phosgene Oxime (CX), an urticant or nettle agent categorized as a vesicant, is a potential chemical warfare and terrorist weapon. Its exposure can result in widespread and devastating effects including high mortality due to its fast penetration and ability to cause immediate severe cutaneous injury. It is one of the least studied chemical warfare agents with no effective therapy available. Read More

    Re-exposure to low osmolar iodinated contrast media in patients with prior moderate-to-severe hypersensitivity reactions: A multicentre retrospective cohort study.
    Eur Radiol 2017 Jul 14;27(7):2886-2893. Epub 2016 Dec 14.
    Division of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
    Objectives: To evaluate the outcomes of re-exposure to low-osmolar iodinated contrast medium (LOCM) in patients with a history of moderate-to-severe hypersensitivity reaction (HSR).

    Methods: We retrospectively evaluated a cohort comprising all subjects satisfying the following conditions at 11 centres: (1) experienced a moderate-to-severe HSR to LOCM by December 2014, and (2) underwent contrast-enhanced computed tomography after the initial HSR between January 2014 and December 2014.

    Results: A total of 150 patients with 328 instances of re-exposure were included; the recurrence rate of HSR was 19. Read More

    Acrally distributed dermatoses: Vascular dermatoses (purpura and vasculitis).
    Clin Dermatol 2017 Jan - Feb;35(1):68-80. Epub 2016 Sep 10.
    Department of Dermatology and Venereology, Tokuda Hospital Sofia, Sofia, Bulgaria.
    Purpuric lesions appear in acral distribution in a variety of conditions and often provide clues to the clinical diagnosis. Purpuric means "hemorrhagic"-that is, the lesions do not blanch from pressure. This review focuses on dermatoses that produce hemorrhagic lesions in acral distribution from the large groups of the vasculitic diseases and their mimics. Read More

    Prevalence of Inducible Urticaria in Patients with Chronic Spontaneous Urticaria: Associated Risk Factors.
    J Allergy Clin Immunol Pract 2017 Mar - Apr;5(2):464-470. Epub 2016 Nov 9.
    Group of Experimental and Clinical Allergy, IPS Universitaria, University of Antioquia, Medellín, Colombia.
    Background: Information on the prevalence of inducible urticaria (IU) in patients with chronic spontaneous urticaria (CSU) and the factors affecting this prevalence is scarce in the literature.

    Objectives: To estimate the frequency of IU in patients with CSU and to explore possible factors associated with CSU.

    Methods: Patients older than 12 years diagnosed with CSU and a control group with no history of urticaria were recruited from 2 different cities. Read More

    Hereditary angioedema with F12 mutation: Clinical features and enzyme polymorphisms in 9 Southwestern Spanish families.
    Ann Allergy Asthma Immunol 2016 11 24;117(5):520-526. Epub 2016 Oct 24.
    Immunology Department, Virgen del Rocío University Hospital, Seville, Spain.
    Background: Information on F12 mutation hereditary angioedema (HAE) is still limited, but Spain is now recognized as having one of the highest concentrations of cases in Western Europe.

    Objective: To describe unique features of HAE in Spanish carriers of the F12 mutation and investigate a potential role for angiotensin-converting enzyme (ACE) and aminopeptidase-P polymorphisms in disease expression.

    Methods: This was a prospective observational cohort study of 35 individuals (80% females) from 9 unrelated families carrying the p. Read More

    Comprehensive technical and patient-care optimization in the management of pediatric apheresis for peripheral blood stem cell harvesting.
    Transfus Apher Sci 2016 Dec 30;55(3):338-343. Epub 2016 Sep 30.
    Department of Pediatric Oncology, Fukushima Medical University, Fukushima, Japan.
    Background: Pediatric apheresis for peripheral blood stem cell transplantation should be carried out with due concern for low corporeal blood volume and vulnerability to hypocalcemia-related complications, hypovolemic shock, and hypervolemic cardiac overload.

    Study Design And Methods: We retrospectively investigated a total of 267 apheresis procedures from 1990 to 2013 on 93 children between 0 and 10 years old, including 89 patients and 4 healthy donors, with body weights of 6.3 to 44. Read More

    Omalizumab in the Treatment of Chronic Inducible Urticaria.
    Actas Dermosifiliogr 2017 Jun 5;108(5):423-431. Epub 2016 Oct 5.
    Servicio de Dermatología, Hospital Universitario de La Princesa, Madrid, España.
    Omalizumab is a recombinant humanized monoclonal antibody that inhibits immunoglobulin E. It has been approved for the treatment of severe asthma and chronic spontaneous urticaria refractory to other treatments. Its use in the management of chronic inducible urticaria (a type triggered by certain stimuli) is still considered off-label, although this use has been discussed in some consensus papers. Read More

    Inducible urticaria: Case series and literature review.
    Biomedica 2016 Mar 3;36(1):10-21. Epub 2016 Mar 3.
    Grupo de Alergología Clínica y Experimental (GACE), IPS Universitaria, Universidad de Antioquia, Medellín, Colombia.
    Inducible urticaria is a heterogeneous group of skin disorders characterized by the appearance of wheals, pruritus and/or angioedema, sometimes accompanied by systemic symptoms caused by innocuous stimuli (cold, heat, pressure, etc.). This group of disorders compromises people's quality of life and most of the literature in this regard comes from case reports and case series since its epidemiology has been poorly studied and some cases are very rare. Read More

    Diagnostic utility of challenge procedures for physical urticaria/angioedema syndromes: a systematic review.
    Curr Opin Allergy Clin Immunol 2016 Oct;16(5):511-5
    aDepartment of Internal MedicinebDepartment of Allergy and Clinical Immunology, Respiratory Institute, Cleveland Clinic, Cleveland, Ohio, USA.
    Purpose Of Review: Physical urticaria/angioedema syndromes (PUAs) are commonly encountered. They are identified by a history of physical factors provoking cutaneous symptoms, and confirmed by provocation testing. Recent guidelines have recommended use of challenge procedures for diagnosis; however, their positive/negative likelihood ratios have not been established. Read More

    Autoreactive IgE in Chronic Spontaneous/Idiopathic Urticaria and Basophil/Mastocyte Priming Phenomenon, as a Feature of Autoimmune Nature of the Syndrome.
    Arch Immunol Ther Exp (Warsz) 2017 Apr 31;65(2):137-143. Epub 2016 Aug 31.
    Department of Internal Medicine and Allergy, Wroclaw Medical University, Curie-Skłodowskiej 66, 50-367, Wrocław, Poland.
    Recent years of research have shed a new light on the role of IgE in immune reactions. It seems to be more than just a contribution to immediate type of allergic response. It appears that monomeric IgE may enhance mast cell activity without cross-linking of FcεRI by IgE specific allergen or autoreactive IgG anti-IgE antibodies. Read More

    A regional approach to unmet needs in anaphylaxis.
    Eur Ann Allergy Clin Immunol 2016 May;48(3):88-93
    Emergency Department, Saint Paul Hospital, Savona, Italy.
    Allergic diseases are under-diagnosed and undertreated despite their wide prevalence, and particularly anaphylaxis is often under-estimated. Evidence-based anaphylaxis guidelines developed by principal allergy organizations agree on increased prevalence of anaphylaxis, especially in patients younger than 18 years (18-27,30): this trend highlights the need for actions on anaphylaxis management and prevention (3,4). Lack of prompt connection between emergency department and allergy unit after discharge, and of a dedicated ICD-9th identification code (18-26), can delay diagnosis and treatment of anaphylaxis (28,29). Read More

    Delayed pressure urticaria treated with the selective serotonin reuptake inhibitor escitalopram.
    Clin Exp Dermatol 2016 Jul 2;41(5):526-8. Epub 2016 Apr 2.
    Department of Psychiatry, Lovisenberg Diakonale Hospital, Oslo, Norway.
    There is increasing evidence of platelet activation and systemic inflammation in chronic spontaneous urticaria and delayed pressure urticaria (DPU). Inflammation may be central to understanding the high comorbidity of depression and anxiety in patients with chronic urticaria (CU). We report a case of DPU and depression in a patient, which responded favourably to treatment with the selective serotonin reuptake inhibitor (SSRI) escitalopram. Read More

    Combined Angiotensin Receptor Antagonism and Neprilysin Inhibition.
    Circulation 2016 Mar;133(11):1115-24
    From Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
    Heart failure affects ≈5.7 million people in the United States alone. Angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, β-blockers, and aldosterone antagonists have improved mortality in patients with heart failure and reduced ejection fraction, but mortality remains high. Read More

    Effective treatment of different phenotypes of chronic urticaria with omalizumab: Case reports and review of literature.
    Int J Immunopathol Pharmacol 2016 Jun 4;29(2):320-8. Epub 2016 Jan 4.
    Department of Internal Diseases, Dermatology and Allergology in Zabrze, SMDZ in Zabrze, Medical University of Silesia in Katowice, Poland.
    Despite the excellent efficacy and safety profile of omalizumab in chronic spontaneous urticaria (CSU), there are scarce data concerning its role in the treatment of refractory cases with different phenotypes of urticaria. We describe our experience with the therapy of nine patients with CSU co-existing with delayed pressure urticaria (DPU) or angioedema or both and refractory to treatment with high-dose antihistamines. The first patient, with severe CSU and recurrent angioedema, did not respond well to cyclosporine A or corticosteroids and suffered from numerous side effects of long-term corticosteroid therapy. Read More

    Cetirizine Quantification by High-Performance Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS).
    Methods Mol Biol 2016 ;1383:115-20
    Department of Pathology and Laboratory Medicine, Children's Mercy Hospitals and Clinics, 2401 Gillham Road, Kansas City, MO, 64108, USA.
    A multiple reaction monitoring (MRM), positive ion electrospray ionization, LC/MS/MS method is described for the quantification of cetirizine. The compound was isolated from human plasma by protein precipitation using acetonitrile. Cetirizine d4 was used as an internal standard. Read More

    An Unusual Allergic Response to Orthodontic Treatment.
    Dent Update 2015 Jul-Aug;42(6):580-2
    This paper describes a case of a 13-year-old patient with a systemic hypersensitivity reaction to orthodontic treatment. Her allergy was investigated resulting in a provisional diagnosis of pressure urticaria. The aetiology, diagnosis and clinical management of allergic reactions to dental procedures are discussed. Read More

    The effects of the El Niño Southern Oscillation on skin and skin-related diseases: a message from the International Society of Dermatology Climate Change Task Force.
    Int J Dermatol 2015 Dec 15;54(12):1343-51. Epub 2015 Oct 15.
    Division of Clinical Dermatology, Mayo Clinic, Rochester, MN, USA.
    The El Niño Southern Oscillation (ENSO) is a complex climate phenomenon occurring in the Pacific Ocean at intervals of 2-7 years. The term refers to fluctuations in ocean temperatures in the tropical eastern Pacific Ocean (El Niño [the warm phase of ENSO] and La Niña [the cool phase of ENSO]) and in atmospheric pressure across the Pacific basin (Southern Oscillation). This weather pattern is attributed with causing climate change in certain parts of the world and is associated with disease outbreaks. Read More

    Snoring-Induced Vibratory Angioedema.
    Am J Case Rep 2015 Oct 1;16:700-2. Epub 2015 Oct 1.
    Department of Internal Medicine, MidMichigan Medical Center, University of Michigan Health System, Midland, MI, USA.
    Background: Vibratory angioedema (VA) is a rare physical urticaria, with symptoms of itching and swelling of the skin or mucosa when it is exposed to vibration. Avoidance of vibration is the best way to manage this condition. This case report will assist physicians to diagnose this rare condition. Read More

    Neutrophilic Epitheliotropism is a Histopathological Clue to Neutrophilic Urticarial Dermatosis.
    Am J Dermatopathol 2016 Jan;38(1):39-49
    *Department of Dermatology, University of Münster, Münster, Germany; †Dermatopathology Laboratory, Dermatologikum, Hamburg, Germany; ‡Department of Dermatology, University of Zürich, Zürich, Switzerland; and §Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany.
    Background: Neutrophilic urticarial dermatosis (NUD) comprises a particular autoinflammatory condition within the spectrum of aseptic neutrophilic dermatoses characterized by a distinct urticarial eruption clinically and a neutrophilic dermatosis histopathologically.

    Objective: In this study, we reviewed skin biopsies of lesional skin of patients seen in our outpatient clinic for autoimmune dermatoses and in allergy department from 1982 to 2014 that fulfilled these criteria.

    Methods: A total of 77 biopsies from 50 patients were analyzed histopathologically. Read More

    Deep Hypothermic Circulatory Arrest in a Patient With Cold-Induced Urticaria.
    Ann Thorac Surg 2015 Aug;100(2):722-3
    Department of Pathology, Clinical Immunology Laboratory, Massachusetts General Hospital, Boston, Massachusetts.
    Acquired cold urticaria is a condition characterized by the onset of pruritic hives, swelling, and occasional severe systemic reactions, during the rewarming phase, after cold exposure. Pulmonary thromboendarterectomy (PTE) is a cardiac surgical procedure where organized thrombus is excised from the pulmonary vasculature in order to improve pulmonary blood flow and relieve pressure on the right ventricle. A PTE requires institution of deep hypothermic circulatory arrest (DHCA) in order to reduce blood flow from collateral vessels during thrombus excision. Read More

    Delayed pressure urticaria: response to treatment with sulfasalazine in a case series of seventeen patients.
    Dermatol Ther 2015 Sep-Oct;28(5):318-22. Epub 2015 Jul 2.
    Dayanand Medical College and Hospital, Tagore Nagar, Civil Lines.
    We retrospectively identified 17 patients with delayed pressure urticaria (DPU), diagnosed by history and confirmed with provocative pressure testing. The average age in the cohort was 42.6 years with 10 women and seven men. Read More

    Management and treatment of chronic urticaria (CU).
    J Eur Acad Dermatol Venereol 2015 Jun;29 Suppl 3:16-32
    Allergy and Clinical Immunology Department, Centro Médico-Docente La Trinidad, Caracas, Venezuela.
    Developments increasing our understanding of chronic urticaria have resulted in the simplification and improvement of available treatments. Currently, many treatments target mast cell mediators, but we can now disrupt mast cell activation with the anti-IgE antibody omalizumab, which has markedly advanced the treatment landscape for patients with difficult-to-treat urticaria. Current guidelines provide a framework for the management and treatment of patients with CU but, as each patient is different, knowledge and experience of specialist dermatologists and allergists are key to effective pharmacotherapy. Read More

    Mast-cell interleukin-1β, neutrophil interleukin-17 and epidermal antimicrobial proteins in the neutrophilic urticarial dermatosis in Schnitzler's syndrome.
    Br J Dermatol 2015 Aug 20;173(2):448-56. Epub 2015 Jul 20.
    Department of Dermatology, Radboud University Medical Center, 6500 HB, Nijmegen, the Netherlands.
    Background: Schnitzler's syndrome (SchS) is an autoinflammatory disease characterized by a chronic urticarial rash, a monoclonal component and signs of systemic inflammation. Interleukin (IL)-1β is pivotal in the pathophysiology.

    Objectives: Here we investigated the cellular source of proinflammatory mediators in the skin of patients with SchS. Read More

    Analysis of circulating vascular endothelial growth factor and its soluble receptors in patients with different forms of chronic urticaria.
    Biomed Res Int 2015 10;2015:578383. Epub 2015 Feb 10.
    Chair and Clinical Department of Internal Diseases, Dermatology and Allergology, Ulica M. Curie-Skłodowskiej 10, Medical University of Silesia in Katowice, 41-800 Zabrze, Poland.
    Background: Vascular endothelial growth factor (VEGF) is a powerful enhancer of vascular permeability and inflammatory response; however its significance in chronic urticaria is poorly recognised.

    Aim: To compare free circulating levels of VEGF and its soluble receptors (sVEGFR1 and VEGFR2) in patients with different forms of chronic urticaria.

    Methods: The concentrations of VEGF and its receptors in plateletpoor plasma (PPP)/plasma were measured using enzyme-linked immunosorbent assay in chronic urticaria: (1) chronic spontaneous urticaria (CSU) with positive autologous serum skin test (ASST), (2) CSU with negative response to ASST, (3) CSU with concomitant euthyroid Hashimoto's thyroiditis (CSU/Hashimoto), (4) delayed pressure urticaria (DPU), and the healthy subjects. Read More

    [Unilateral periocular angioedema after application of contrast agent].
    Ophthalmologe 2015 Oct;112(10):854-6
    Klinik für Augenheilkunde, Universitätsklinikum Freiburg, Killianstr. 5, 79106, Freiburg, Deutschland.
    This article presents a case report of unilateral, periocular angioedema after intravenous application of a contrast agent with a temporary increase of intraocular pressure in an eye in which trabeculectomy had been carried out 5 weeks previously. Read More

    [An uncommon cause of delayed walking: idiopathic palmoplantar hidradenitis].
    Arch Pediatr 2015 Mar 27;22(3):306-8. Epub 2015 Jan 27.
    Service de pédiatrie, CHU Mohamed VI, Marrakech, Maroc.
    Introduction: Idiopathic palmoplantar hidradenitis is an uncommon neutrophilic dermatosis, occurring in children and young adults. Its pathogenesis is incompletely understood. It is characterized by spontaneous resolution, but it can relapse in 50% of cases. Read More

    [Angioedema and urticaria].
    Ann Dermatol Venereol 2014 Nov;141 Suppl 3:S586-95
    Centre national de référence des angioedèmes (CREAK), CHU de Grenoble, Hôpital Nord, Boulevard de la Chantourne, 38700 La Tronche, France; Clinique universitaire de médecine interne, Pôle pluridisciplinaire de médecine, CHU de Grenoble - Hôpital Albert Michallon, BP 217, Boulevard de la Chantourne, 38043 Grenoble cedex 9, France.
    Angiœdema (AE) is the clinical expression of urticaria (U) which occurs when urticaria is located within the subcutis. It is a syndrome characterized by a sudden and limited subcutaneous and/or submucous swelling. The updated classification of urticaria distinguishes acute and chronic urticaria. Read More

    Validation of a simplified provocation instrument for diagnosis and threshold testing of symptomatic dermographism.
    Clin Exp Dermatol 2015 Jun 18;40(4):399-403. Epub 2014 Dec 18.
    Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité-Universitätsmedizin Berlin, Berlin, Germany.
    Background: Symptomatic dermographism is a common urticarial condition, which requires determination of provocation thresholds to confirm diagnosis and allow physicians to individualize management and therapy for optimal control of symptoms. To determine provocation thresholds, we have developed a provocation test device, the FricTest(®) 4.0. Read More

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