5,696 results match your criteria Urticaria Chronic


Current and Future Approaches in Management of Chronic Spontaneous Urticaria Using Anti-IgE Antibodies.

Medicina (Kaunas) 2022 Jun 17;58(6). Epub 2022 Jun 17.

Dermatology Department, "Elias" University Emergency Hospital, 011461 Bucharest, Romania.

Chronic spontaneous urticaria (CSU) considerably alters patients' quality of life, often for extended periods, due to pruriginous skin lesions, impaired sleep, unexpected development of angioedema, and failure of conventional treatments in properly controlling signs and symptoms. Recent research focused on the development of new therapeutic agents with higher efficacy. Although the production of specific immunoglobulin E (IgE) antibodies against certain allergens is not a characteristic of the disease, treatment with omalizumab, a monoclonal anti-IgE antibody, proved efficient and safe in patients with moderate to severe chronic spontaneous urticaria uncontrolled by H1-antihistamines. Read More

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Immuno-Pathogenesis of Chronic Inflammatory Skin Diseases: Novel Molecular Targets and Biomarkers.

Life (Basel) 2022 Jun 15;12(6). Epub 2022 Jun 15.

Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, SA, Italy.

Chronic inflammation has a crucial pathogenetic role in many diseases, including cutaneous chronic inflammatory disorders, such as psoriasis, atopic dermatitis, hidradenitis suppurativa, and chronic urticaria [... Read More

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CAN SKIN BE A MARKER FOR INTERNAL MALIGNANCY? EVIDENCE FROM CLINICAL CASES.

Acta Clin Croat 2021 Dec;60(4):711-721

1Department of Dermatovenereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; 2School of Dental Medicine, University of Zagreb, Zagreb, Croatia; 3Unit of Dermatology and Venereology, Zabok General Hospital, Bračak/Zabok, Croatia; 4Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; 5Ljudevit Jurak Department of Pathology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.

Although there are many single case reports on paraneoplastic dermatoses in the literature, there are very rare articles containing multiple cases. A retrospective study was performed to examine paraneoplastic dermatoses and accompanying malignancies based on skin manifestations and appropriate diagnostic evaluations. We recorded outcomes, current conditions, and surgical/oncologic treatments. Read More

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December 2021

Urticaria and angioedema in children and adolescents: diagnostic challenge.

Allergol Immunopathol (Madr) 2022 17;50(S Pt 1):17-29. Epub 2022 May 17.

Division of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, McGill University Health Centre, Montreal, Canada.

Urticaria diagnosis may be challenging in children since it can be triggered or related to numerous conditions. In this paper, we reviewed the main aspects regarding the diagnosis of urticaria in the pediatric population. Acute urticaria is often due to viral infections. Read More

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Omalizumab is not just an anti-immunoglobulin E.

J Dermatolog Treat 2022 Jun 20:1-4. Epub 2022 Jun 20.

Department of Dermatology, University of Gaziantep Faculty of Medicine, Gaziantep, Turkey.

Introduction And Purpose: The mechanism of omalizumab in urticaria is not literally known. Omalizumab may affect receptors on the mast cell surface in other ways, especially other than Fc epsilon RI.

Materials And Methods: Thirty patients who were treated with omalizumab with the diagnosis of chronic urticaria were included in the study. Read More

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The course of COVID-19 in patients with chronic spontaneous urticaria receiving omalizumab treatment.

Rev Fr Allergol (2009) 2022 Jun 13. Epub 2022 Jun 13.

University of Health Science, Konya City Hospital, Department of Allergy and Clinical Immunology, Konya, Turkey.

Background And Aim: Although there are case reports and guideline recommendations that states omalizumab can be used in chronic spontaneous urticaria (CSU) patients during SARS-CoV-2 pandemic, there are scarce studies showing the course of Coronavirus disease 2019 (COVID-19) in CSU patients receiving omalizumab.

Materials And Methods: A total of 370 patients with chronic urticaria were included in the study between June 2020 and December 31, 2020.

Results: Sixty patients (16. Read More

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Internalized stigma in chronic urticaria: A case-control study.

Australas J Dermatol 2022 Jun 18. Epub 2022 Jun 18.

Department of Dermatology and Venereology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.

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IgG Autoantibodies Against IgE from Atopic Dermatitis Can Induce the Release of Cytokines and Proinflammatory Mediators from Basophils and Mast Cells.

Front Immunol 2022 31;13:880412. Epub 2022 May 31.

Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.

IgE-mediated release of proinflammatory mediators and cytokines from basophils and mast cells is a central event in allergic disorders. Several groups of investigators have demonstrated the presence of autoantibodies against IgE and/or FcεRI in patients with chronic spontaneous urticaria. By contrast, the prevalence and functional activity of anti-IgE autoantibodies in atopic dermatitis (AD) are largely unknown. Read More

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The Role of Crosstalk of Immune Cells in Pathogenesis of Chronic Spontaneous Urticaria.

Front Immunol 2022 31;13:879754. Epub 2022 May 31.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.

Chronic spontaneous urticaria (CSU) is defined as recurrent episodes of spontaneous wheal development and/or angioedema for more than six weeks and at least twice a week. The core link in the pathogenesis of CSU is the activation of mast cells, T cells, eosinophils, and other immune cells infiltrating around the small venules of the lesion. Increased vascular permeability, vasodilatation, and recruitment of inflammatory cells directly depend on mast cell mediators' release. Read More

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Combined treatment with omalizumab and secukinumab in a patient with chronic spontaneous urticaria and psoriasis.

Dermatol Ther 2022 Jun 15:e15638. Epub 2022 Jun 15.

Pamukkale University, Department of Dermatology, Denizli, Turkey.

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Artificial intelligence processing electronic health records to identify commonalities and comorbidities cluster at Immuno Center Humanitas.

Clin Transl Allergy 2022 Jun 8;12(6):e12144. Epub 2022 Jun 8.

Department of Biomedical Sciences Humanitas University Milan Italy.

Background: Comorbidities are common in chronic inflammatory conditions, requiring multidisciplinary treatment approach. Understanding the link between a single disease and its comorbidities is important for appropriate treatment and management. We evaluate the ability of an NLP-based process for knowledge discovery to detect information about pathologies, patients' phenotype, doctors' prescriptions and commonalities in electronic medical records, by extracting information from free narrative text written by clinicians during medical visits, resulting in the extraction of valuable information and enriching real world evidence data from a multidisciplinary setting. Read More

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Chronic Urticaria in a Child With Nephrotic Syndrome: A Double Whammy!

Indian Pediatr 2022 Jun;59(6):505-506

Department of Dermatology, Venereology and Leprology, Sardar Patel Medical College, Bikaner, Rajasthan.

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The Burden on Cohabitants of Patients with Chronic Spontaneous Urticaria: A Cross-Sectional Study.

J Clin Med 2022 Jun 6;11(11). Epub 2022 Jun 6.

Dermatology Unit, Hospital Universitario Virgen de las Nieves, IBS Granada, 18002 Granada, Spain.

Chronic Spontaneous Urticaria (CSU) has been associated with patients' poor quality of life. Despite being a chronic disease that could alter the quality of life of the people who live with patients, the potential burden on their cohabitants has not been studied to date. The aim of this study is to analyze the relationship between the patient's quality of life, disease control, disease duration and family quality of life and the cohabitant's mood disturbances, sexual dysfunction, type D personality and sleep quality. Read More

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Rome IV Criteria-Defined Irritable Bowel Syndrome in Atopic Patients and the Effect of Anxiety and Depression: A Case-Control Study.

Turk J Gastroenterol 2022 May;33(5):397-405

Department of Internal Medicine, Gastroenterology Division, Akdeniz University Faculty of Medicine, Antalya, Turkey.

Background: Numerous studies report an increased prevalence of irritable bowel syndrome in patients with atopic diseases such as allergic rhinitis, allergic asthma, and chronic urticaria. Both disease groups have a higher incidence of psychological disorders. In this study, we aimed to examine the relationship of irritable bowel syndrome with the presence and severity of allergic diseases and accom- panying anxiety and depression. Read More

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Autoimmune chronic spontaneous urticaria.

J Allergy Clin Immunol 2022 Jun;149(6):1819-1831

Institute of Allergology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, and Humboldt-Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany. Electronic address:

Chronic spontaneous urticaria (CSU) is a debilitating mast cell-driven disease characterized by recurrent wheals and/or angioedema. Substantial progress has been made in dissecting the 2 main autoimmune mechanisms that drive the pathogenesis of CSU. Type I autoimmune (autoallergic) CSU is associated with IgE antibodies against autoantigens, for example, thyroid peroxidase and IL-24. Read More

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Plasma-derived exosomes in chronic spontaneous urticaria induce the production of mediators by human mast cells.

J Invest Dermatol 2022 Jun 1. Epub 2022 Jun 1.

Department of Dermatovenereology, West China Hospital of Sichuan University. Chengdu, 610041, China. Electronic address:

Mast cell activation and inflammatory mediators play central roles in the pathogenesis of chronic spontaneous urticaria (CSU). The factors that induce mast cell activation in CSU are still largely unknown. Exosomes are extracellular vesicles that activate mast cells. Read More

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Chronic Spontaneous Urticaria: An Etiopathogenic Study.

Indian J Dermatol 2022 Jan-Feb;67(1):92

Department of Biochemistry, Lady Hardinge Medical College, New Delhi, India.

Importance: Exact etiopathogenesis of chronic spontaneous urticaria (CSU) remains elusive. Infections, pseudoallergens, autoimmunity, and contact sensitization are various postulated factors. Few studies are available measuring cytokine levels in CSU. Read More

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Clinical and Genetic Characteristics of Ectodermal Dysplasia in Four Indian Children.

Indian J Dermatol 2022 Jan-Feb;67(1):54-57

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Introduction: Ectodermal dysplasias (EDs) affect structures derived from the ectoderm such as skin, its appendages, nail, and teeth. In this series, we describe four patients presenting with a clinical phenotype of dysplasia of one or more ectodermal structures who underwent next-generation sequencing for mutational analysis.

Case Series: The clinical phenotype of three patients was hypohidrotic ectodermal dysplasia (HED) and one patient was diagnosed with autoimmune polyglandular syndrome (APS) type 1. Read More

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Epidemiology and natural history of childhood-acquired chronic hepatitis C: a single-centre long-term prospective study.

J Pediatr Gastroenterol Nutr 2022 Jun 1. Epub 2022 Jun 1.

Liver Unit, Meyer Children's University Hospital, University of Florence, Florence, Italy.

Objectives: To prospectively describe the epidemiology and long-term outcome of childhood-acquired hepatitis C virus (HCV) infection in a large cohort of children followed at a single centre.

Methods: All children with chronic HCV infection followed at the Liver Unit of our tertiary Hospital in Florence (Italy) from January 1st, 1988, to September 30th, 2021, were included in the analysis.

Results: The final sample consisted of 163 children (median age at enrolment 4 years, interquartile range - IQR - 10; median age at last follow-up 14 years, IQR 7). Read More

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Chlorpheniramine, an Old Drug with New Potential Clinical Applications: A Comprehensive Review of the Literature.

Curr Rev Clin Exp Pharmacol 2022 Jun 1. Epub 2022 Jun 1.

Lake Erie College of Osteopathic Medicine, Bradenton, FL, USA.

Chlorpheniramine Maleate (CPM), also known as chlorphenamine, is a potent alkylamine first-generation H1 antihistamine that has been around since the 1950s. CPM is a widely popular drug commonly used to treat allergic conditions, given its antihistamine properties. Although mainly used in over-the-counter treatment for cough and colds, various studies discuss a wide range of CPM's clinical uses, such as treating asthma, plasma cell gingivitis, chronic urticaria, depression, among others. Read More

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Chronic spontaneous urticaria after COVID-19 primary vaccine series and boosters.

JAAD Case Rep 2022 Jul 26;25:63-66. Epub 2022 May 26.

Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

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Alexithymia and Cutaneous Disease Morbidity: A Systematic Review.

Dermatology 2022 May 30:1-10. Epub 2022 May 30.

Section Cognitive Neuroscience, Department of Biomedical Sciences of Cells & Systems, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Background: Alexithymia is a psychological construct that describes one's difficulty in understanding and describing their own emotions as well as differentiating feelings from bodily signals of arousal. In the general population, alexithymia's prevalence is approximately 10%. Alexithymia may act as a triggering factor for many medical and psychiatric disorders. Read More

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Bruton's Kinase Inhibitors for the Treatment of Immunological Diseases: Current Status and Perspectives.

J Clin Med 2022 May 16;11(10). Epub 2022 May 16.

Department of Hematology, Medical University of Lodz, 93-510 Lodz, Poland.

The use of Bruton's tyrosine kinase (BTK) inhibitors has changed the management of patients with B-cell lymphoid malignancies. BTK is an important molecule that interconnects B-cell antigen receptor (BCR) signaling. BTK inhibitors (BTKis) are classified into three categories, namely covalent irreversible inhibitors, covalent reversible inhibitors, and non-covalent reversible inhibitors. Read More

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Clinical and Socio-Demographic Variables Associated with the Diagnosis of Long COVID Syndrome in Youth: A Population-Based Study.

Int J Environ Res Public Health 2022 05 15;19(10). Epub 2022 May 15.

ADHD Unit, Geha Mental Health Center, Petah Tikva 49100, Israel.

This study examines the demographic, clinical and socioeconomic factors associated with diagnosis of long COVID syndrome (LCS). Data of 20,601 COVID-19-positive children aged 5 to 18 years were collected between 2020 and 2021 in an Israeli database. Logistic regression analysis was used to evaluate the adjusted odds ratio for the characteristics of the COVID-19 infection and pre-COVID-19 morbidities. Read More

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Chronic spontaneous urticaria following COVID-19 vaccination.

JAAD Case Rep 2022 Jul 21;25:35-38. Epub 2022 May 21.

Department of Dermatology, Cliniques universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium.

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Chronic spontaneous urticaria: a low-grade disseminated intravascular coagulation only partially reversed by Omalizumab.

Clin Exp Med 2022 May 25. Epub 2022 May 25.

Department of Medical Sciences and Public Health, and Unit of Internal Medicine, University of Cagliari, Policlinico Universitario - AOU di Cagliari Azienda Ospedaliero Universitaria, SS 554-Bivio Sestu, 09042, Monserrato, CA, Italy.

Chronic spontaneous urticaria (CSU) is a disorder characterized by wheals and/or angioedema. The coagulation cascade and inflammation pathways are closely linked together. The aim of our study was first to investigate the dynamics of clot formation in plasma (Clot Waveform Analysis, CWA) in a group of 47 patients with CSU along with other coagulative parameters dedicated to the study of hypercoagulability, such as D-Dimer, F 1 + 2 peptide, Fibrinogen, Platelet count and Mean Platelet Volume (MPV). Read More

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Delayed Pressure Urticaria: Clinical and Diagnostic Features and Response to Omalizumab.

Int Arch Allergy Immunol 2022 May 24:1-6. Epub 2022 May 24.

Allergy Department, Complexo Hospitalario Universitario A Coruña, A Coruña, Spain.

Background: Delayed pressure urticaria (DPU) is a rare form of chronic inducible urticaria (CIndU) when it manifests alone. Treatment of DPU is disappointing owing to the lack of response to antihistamines, even when up-dosing. In addition, the absence of randomized clinical trials and the low number of patients included in the studies mean that there is little scientific evidence for the validity of omalizumab in DPU. Read More

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The Impact of Bilastine on Symptoms of Allergic Rhinitis and Chronic Urticaria: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Am J Rhinol Allergy 2022 May 20:19458924221097449. Epub 2022 May 20.

68865Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Background: Allergic diseases are immunological exaggerations with symptoms that may interfere with life quality. Bilastine, a novel oral second-generation H-1 antihistamine, is highly selective to H-1 receptors and has anti inflammatory properties. The present evidence regarding the drug efficacy is inconsistent. Read More

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Effectiveness and safety of dupilumab in patients with chronic rhinosinusitis with nasal polyps and associated comorbidities: a multicentric prospective study in real life.

Clin Mol Allergy 2022 May 19;20(1). Epub 2022 May 19.

UO Allergologia e Immunologia Clinica, ASST Mantova, Mantova, Italy.

Background: Biologics are currently one of the main treatment options for a number of diseases. The IgG4 monoclonal antibody dupilumab targets the Interleukin-4 receptor alpha chain, thus preventing the biological effects of the cytokines IL-4 and IL-13, that are essential for the Th2 response. Several controlled trials showed that dupilumab is effective and safe in patients with atopic dermatitis (AD), severe asthma and chronic rhinosinusitis with nasal polyps (CRSwNP), thus resulting in approval by regulatory agencies. Read More

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