5,003 results match your criteria Urticaria Chronic


Assessment of thiol/disulphide homeostasis and ischemia modified albumin and their relationship with disease severity in children with chronic urticaria.

Cutan Ocul Toxicol 2020 Jul 2:1-19. Epub 2020 Jul 2.

Department of Biochemistry, Yildirim Beyazit University Faculty of Medicine, Ankara, Turkey.

The pathogenesis chronic urticaria (CU) hasn't been fully understood. In recent years, it has been shown that thiol-disulphide homeostasis, as an antioxidant system, plays important roles in both healthy individuals and various diseases. In different ischemia-reperfusion states high oxidative stress causes ischemia modified albumin (IMA) generation. Read More

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http://dx.doi.org/10.1080/15569527.2020.1790589DOI Listing

Novel Therapeutic Approaches And Targets For Treatment Of Chronic Urticaria: New Insights And Promising Targets For A Challenging Disease.

Curr Pharm Biotechnol 2020 Jun 30. Epub 2020 Jun 30.

Dermatological Clinic, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona. Italy.

Background: Chronic spontaneous urticaria (CSU) is a disease characterized by the onset of wheals and/or angioedema over 6 weeks. The pathophysiology for CSU is very complex, involving mast cells and basophils with a multitude of inflammatory mediators. For many years the treatment of CSU has been based on the use of antihistamines, steroids and immunosuppressive agents with inconstant and frustrating results. Read More

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http://dx.doi.org/10.2174/1389201021666200630140137DOI Listing

Cyclosporin in Dermatology: A Practical Compendium.

Dermatol Ther 2020 Jun 30:e13934. Epub 2020 Jun 30.

Department of Medicine, The Aga Khan University Hospital, Karachi-Pakistan.

Cyclosporine A belongs to calcineurin inhibitor family, which has the ability to selectively suppress T-cells. Owing to its immune-modulatory effects, it had been in use for graft versus host diseases and organ transplant rejection for many years, but in dermatology, it was first approved for use in 1997 in the treatment of psoriasis. Other off label indications for skin diseases includes atopic dermatitis, chronic spontaneous urticaria, lichen planus, pyoderma gangrenosum, alopecia areata, granuloma annulare and several others. Read More

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http://dx.doi.org/10.1111/dth.13934DOI Listing

Methotrexate combined with omalizumab for difficult to treat urticaria: a further step-up treatment?

Clin Exp Dermatol 2020 Jun 29. Epub 2020 Jun 29.

Department of Dermatology, Ninewells Hospital and Medical School, Dundee, UK.

Classically, chronic urticaria has been treated following a stepwise approach where Omalizumab and other immunosuppressants occupy the last step. Omalizumab and Methotrexate have both been used separately for the treatment of urticaria . We believe combination treatment with both agents is a valuable alternative for refractory chronic urticaria and other related diseases such as urticarial vasculitis. Read More

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http://dx.doi.org/10.1111/ced.14359DOI Listing

Experience with Omalizumab for the Treatment of Chronic Spontaneous Urticaria in a Tertiary Center: Real life experience.

Cutan Ocul Toxicol 2020 Jun 28:1-16. Epub 2020 Jun 28.

Department of Dermatology and Venereology, Ege University Faculty of Medicine, Izmir.

Purpose: Chronic spontaneous urticaria (CSU) is defined as urticaria and/or angioedema that appears spontaneously due to known or unknown causes and lasts for at least 6 weeks. Omalizumab, an anti-IgE antibody that binds circulating free IgE, has recently emerged as a promising treatment for CSU, a condition which impairs patients' quality of life. We aimed to contribute real life data by reporting our experience with omalizumab in the treatment of intractable CSU. Read More

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http://dx.doi.org/10.1080/15569527.2020.1787432DOI Listing

Cholinergic Urticaria: Clinical Presentation and Natural History in a Tropical Country.

Biomed Res Int 2020 24;2020:7301652. Epub 2020 May 24.

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Cholinergic urticaria (CholU) is a subset of chronic inducible urticaria characterized by the recurrent pinpoint-sized wheals that are induced by exercising or increasing core body temperature. Currently, the data of CholU in tropical climate is still limited.

Objective: To investigate the clinical features and natural course of CholU in a tropical country. Read More

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http://dx.doi.org/10.1155/2020/7301652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273400PMC

FACTORS CONTRIBUTING TO CHRONIC URTICARIA/ANGIOEDEMA AND NUMMULAR ECZEMA RESOLUTION - WHICH FINDINGS ARE CRUCIAL?

Acta Clin Croat 2019 Dec;58(4):595-603

1Department of Dermatovenereology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 2School of Dental Medicine, University of Zagreb, Zagreb, Croatia.

When working with dermatology patients, the question sometimes arises which diagnostic tests and tools should be used for workup, particularly in cases of chronic urticaria (CU) and discoid nummular eczema, where the treatment of associated systemic diseases and infections may be crucial for patient outcome. The aim was to investigate retrospectively the influence of associated diseases on skin disease outcomes based on medical records of CU and nummular eczema patients in comparison to controls. We included patients admitted to our Dermatology Department over a 6-year period and analyzed their laboratory findings, related factors and outcomes recorded after two years of workup and treatment. Read More

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http://dx.doi.org/10.20471/acc.2019.58.04.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314308PMC
December 2019

Urticaria and the gut.

Curr Opin Allergy Clin Immunol 2020 Aug;20(4):381-385

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Dermatology and Allergy, Allergy Center Charité, Berlin, Germany.

Purpose Of Review: To review recent evidence on the association of urticaria and the gut diseases, focusing on the roles of chronic inflammation with or without Helicobacter pylori (H. Pylori) infection.

Recent Findings: The connection between the gut and urticaria has been discussed for a long time. Read More

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http://dx.doi.org/10.1097/ACI.0000000000000653DOI Listing

Severe chronic spontaneous urticaria in children - treatment options according to the guidelines and beyond - a 10 years review.

J Dermatolog Treat 2020 Jun 26:1-4. Epub 2020 Jun 26.

Department of Dermatology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

This is a retrospective study of 18 children with chronic spontaneous urticaria (CSU), where standard therapies, including up-dosing of antihistamines and omalizumab, were unable to cure the disease and where alternative strategies with experimental and off-label medication had to be used. Being aware that our questionnaire is validated only for elder children or adults, we utilized the UAS7 to monitor disease control with the help of the parents. The UAS7 score decreased from a mean of 25 to an average of 13 after 8 weeks of therapy in 13 patients. Read More

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http://dx.doi.org/10.1080/09546634.2020.1782326DOI Listing

Down-regulation of Gremlin1 inhibits inflammatory response and vascular permeability in chronic idiopathic urticaria through suppression of TGF-β signaling pathway.

Gene 2020 Jun 21:144916. Epub 2020 Jun 21.

Department of Dermatology, The Second Hospital of Jilin University, Changchun 130041, P.R. China. Electronic address:

Chronic idiopathic urticaria (CIU) is an unfavorable skin condition which could be maintained for six weeks or longer time. Gremlin1 (GREM1) was recently applied in treatments of many diseases. However, the possible regulatory mechanism of GREM1 in CIU remained unclear. Read More

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http://dx.doi.org/10.1016/j.gene.2020.144916DOI Listing

Allergy clinics in times of the SARS-CoV-2 pandemic: an integrated model.

Clin Transl Allergy 2020 18;10:23. Epub 2020 Jun 18.

Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center IRCCS, Via Alessandro Manzoni 56, Rozzano, MI Italy.

Background: Almost the entire World is experiencing the Coronavirus-Disease-2019 (COVID-19) pandemic, responsible, at the end of May 2020, of more than five million people infected worldwide and about 350,000 deaths. In this context, a deep reorganization of allergy clinics, in order to ensure proper diagnosis and care despite of social distancing measures expose, is needed.

Main Text: The reorganization of allergy clinics should include programmed checks for severe and poorly controlled patients, application of digital medicine service for mild-to-moderate disease in well-controlled ones, postponement of non urgent diagnostic work-ups and domiciliation of therapies, whenever possible. Read More

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http://dx.doi.org/10.1186/s13601-020-00333-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299638PMC

Is vitamin D concentration an indicator of the severity of atopic dermatitis and chronic spontaneous urticaria in adults?

Pol Merkur Lekarski 2020 Jun;48(285):166-169

Department of Dermatology, Jagiellonian University Medical College, Krakow, Poland.

Atopic dermatitis (AD) and chronic spontaneous urticaria (CSU) are common chronic and recurrent dermatoses. The role of vitamin D in the immunological processes, including the development of inflammation, has been the subject of numerous studies. The feasible measurement of vitamin D serum concentration and possibly supplementation necessitates the assessment of its impact on the clinical severity of mentioned diseases. Read More

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Prevalence of chronic urticaria refractory to antihistamines in andalucia, spain.

Dermatol Ther 2020 Jun 18:e13866. Epub 2020 Jun 18.

Department of Dermatology, Hospital Universitario San Cecilio, Granada, Spain.

Introduction: Chronic urticaria (CU) has a devastating effect on the quality of life of patients who suffer from it. The objective of this study is to determine the prevalence of severe CSU in adults in 8 health areas in Andalucía.

Material And Methods: A retrospective observational study from January to December 2019 was conducted with the participation of 7 reference hospitals that were analysed, including including a total reference population of 3. Read More

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http://dx.doi.org/10.1111/dth.13866DOI Listing

Chiral Discrimination of P-glycoprotein in Parturient Women: Effect of Fluoxetine on Maternal-Fetal Fexofenadine Pharmacokinetics.

Pharm Res 2020 Jun 17;37(7):131. Epub 2020 Jun 17.

Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.

Background And Objective: Fluoxetine, antidepressant widely-used during pregnancy, is a selective inhibitor for P-glycoprotein (P-gp). Fexofenadine, an in vivo P-gp probe, is an antihistamine drug for seasonal allergic rhinitis and chronic urticaria treatment during pregnancy and it is available as a racemic mixture. This study evaluated the chiral discrimination of P-gp investigating the effect of fluoxetine on maternal-fetal pharmacokinetics of fexofenadine. Read More

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http://dx.doi.org/10.1007/s11095-020-02854-4DOI Listing

Efficacy of Omalizumab in Chronic Spontaneous Urticaria Associated with Chronic Inducible Urticaria.

Ann Allergy Asthma Immunol 2020 Jun 13. Epub 2020 Jun 13.

Serviço de Imunologia, Hospital Universitário Clementino Fraga Filho (HUCFF-UFRJ).

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http://dx.doi.org/10.1016/j.anai.2020.06.011DOI Listing

Recurrent Type III Kounis Syndrome: Will Anti-Immunoglobulin E Drug Be Another Option?

Can J Cardiol 2020 Jun 10;36(6):966.e5-966.e6. Epub 2019 Dec 10.

Division of Cardiology, Tianjin 1st Central Hospital, Tianjin, China. Electronic address:

Kounis syndrome was recognized as the concurrence of acute cardiovascular events with hypersensitivity reactions. We report a case of Kounis syndrome type III (coronary thrombosis) variant in a 48-year-old man who had experienced recurrent acute myocardial infarctions after scallion-induced hypersensitivity reactions. After appropriate antithrombotic, antihistamine, and reperfusion strategies, the patient was found to have elevated levels of immunoglobulin E and chronic urticaria. Read More

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http://dx.doi.org/10.1016/j.cjca.2019.12.007DOI Listing

Cupping therapy for patients with chronic urticaria: A systematic review and meta-analysis.

J Integr Med 2020 May 28. Epub 2020 May 28.

Graduate School, Chengdu University of Traditional Chinese Medicine, Chengdu 610000, Sichuan Province, China. Electronic address:

Background: Chronic urticaria (CU) is a common skin disease, which has a negative effect on quality of life. Current treatments do not fully control the symptoms of urticaria for many CU patients, thus effective and safe treatments for CU are still needed.

Objective: This review aims to evaluate the effectiveness and safety of cupping therapy in patients with CU. Read More

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http://dx.doi.org/10.1016/j.joim.2020.05.004DOI Listing

Clinical predictive factors of unresponsiveness to omalizumab in patients with chronic spontaneous urticaria.

Br J Dermatol 2020 Jun 12. Epub 2020 Jun 12.

Hospices Civils de Lyon, Clinical immunology and Allergology, Pierre-Bénite, France.

Chronic spontaneous urticaria (CSU) is an inflammatory disease which is characterized by spontaneous appearance of wheals (hives), angioedema or both for at least six weeks. Approximately 10% of patients suffering from CSU are unresponsive to second-generation H1-antihistamines. For these severe cases, recommendation is a treatment by omalizumab (OMZ) -a humanized anti-IgE monoclonal antibody. Read More

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http://dx.doi.org/10.1111/bjd.19312DOI Listing

Primary Non-Adherence to Antihistamines-Conclusions From E-Prescription Pilot Data in Poland.

Front Pharmacol 2020 21;11:783. Epub 2020 May 21.

First Department of Family Medicine, Medical University of Lodz, Łódź, Poland.

Background: In allergic conditions such as allergic rhinitis and urticaria, orally administered H-antihistamines belong to first-line therapy and therefore, are widely prescribed. Due to the frequent, and often chronic, course of allergic diseases, adherence is of great importance. In 2018 a novel, nationwide e-prescription system was piloted in Poland, which allowed to analyze primary non-adherence to orally administered H antihistamines. Read More

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http://dx.doi.org/10.3389/fphar.2020.00783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253696PMC

Articular angioedema in patients with chronic spontaneous urticaria is frequently misdiagnosed as arthritis.

J Allergy Clin Immunol Pract 2020 Jun 7. Epub 2020 Jun 7.

The Proteomic and Flow Cytometry Unit, Allergy and Clinical Immunology, Bnai-Zion Medical Center, Faculty of Medicine, Technion, Haifa, Israel. Electronic address:

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http://dx.doi.org/10.1016/j.jaip.2020.05.043DOI Listing

Food allergy? Intolerance? – Examination of adverse reactions to foods in 406 adult patients

Orv Hetil 2020 06;161(25):1042-1049

Általános Orvostudományi Kar, Bőr-, Nemikórtani és Bőronkológiai Klinika,Semmelweis Egyetem Budapest.

Introduction: The prevalence of adverse food reactions is increasing, with 10-20% of the adult population experiencing such complaints. Most symptoms are thought to be indicators of food allergy, although non-immune-mediated food intolerance and other (e.g. Read More

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http://dx.doi.org/10.1556/650.2020.31753DOI Listing

Sensitization against skin resident fungi is associated with atopy in cholinergic urticaria patients.

Clin Transl Allergy 2020 1;10:18. Epub 2020 Jun 1.

Department of Dermatology and Allergy, Allergie-Centrum-Charité/ECARF, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

Background: Cholinergic urticaria (CholU) is a common type of chronic inducible urticaria, characterized by small itchy wheals that appear upon physical exercise or passive warming. , a skin resident fungus, has been identified as an antigen that induces mast cell/basophil degranulation and wheal formation through specific IgE, in Japanese patients with atopic dermatitis and CholU. In this study we aimed in assessing the rate of IgE sensitizations against skin resident fungi in European CholU patients. Read More

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http://dx.doi.org/10.1186/s13601-020-00324-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262772PMC

Acquired angioedema induced by angiotensin-converting enzyme inhibitors - experience of a hospital-based allergy center.

Exp Ther Med 2020 Jul 27;20(1):68-72. Epub 2020 Jan 27.

Dermatology Research Laboratory, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Angiotensin-converting enzyme inhibitors (ACEIs) represent an important group of pharmacological compounds, largely prescribed for more than 30 years. They have been extensively evaluated in clinical trials, demonstrating significant reduction of morbidity and mortality of patients with cardiovascular diseases, mainly high blood pressure, myocardial infarction, heart failure and stroke. Besides their beneficial effects and a general good safety profile, it was proven that ACEIs might also induce adverse effects in some patients, most notably angioedema (AE) and chronic cough. Read More

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http://dx.doi.org/10.3892/etm.2020.8474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271703PMC

Biologics for Allergic Dermatologic Diseases.

Curr Allergy Asthma Rep 2020 Jun 6;20(8):35. Epub 2020 Jun 6.

Northwestern University Feinberg School of Medicine, 363 W. Erie Street, Suite 350, Chicago, IL, 60616, USA.

Purpose Of Review: Atopic dermatitis (AD), chronic spontaneous urticaria (CSU), and allergic contact dermatitis (ACD) represent three important allergic dermatoses with many unmet therapeutic needs. The development of biologic agents has opened the door to both new treatment options and improved understanding of the underlying pathophysiology, both shared and unique for these entities. With several FDA-approved medications available and many more in development, the biologic revolution has begun for allergic dermatoses. Read More

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http://dx.doi.org/10.1007/s11882-020-00923-7DOI Listing

Chronic Urticaria in Children: an Update on Diagnosis and Treatment.

Curr Allergy Asthma Rep 2020 Jun 6;20(8):31. Epub 2020 Jun 6.

Dept. of Pediatrics, Div. of Allergy and Immunology, National Jewish Health, Denver, CO, 80206, USA.

Purpose Of Review: Both adults and children are frequently affected by symptoms of itchy urticarial lesions that cause considerable distress and impact nearly all their daily activities. A comprehensive history is critical to identify the etiology in patients who have chronic spontaneous urticaria (CSU) (those with symptoms for > 6 weeks) and is more important than extensive laboratory serum tests. Unfortunately, most of the current treatment guidelines have been based on data from adult studies since there is rare data on children. Read More

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http://dx.doi.org/10.1007/s11882-020-00929-1DOI Listing

Efficacy of Fexofenadine in the Treatment of Chronic Idiopathic Urticaria.

Mymensingh Med J 2020 Apr;29(2):414-419

Dr Hasna Jahan, Assistant Professor, Army Medical College Bogura, Bogura, Bangladesh; E-mail:

Urticaria is a common clinical condition that gives a major concern for physicians and patients alike. Urticaria is referred to as chronic when wheals occur daily or almost daily for a period of at least six weeks. The primary purpose of this study is to find out the efficacy of fexofenadine in the treatment of chronic idiopathic urticaria patients among the Bangladeshi population. Read More

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Considerations on Biologicals for Patients with allergic disease in times of the COVID-19 pandemic: an EAACI Statement.

Allergy 2020 Jun 5. Epub 2020 Jun 5.

Translational Medicine Program, Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, Toronto, Ontario, Canada.

The outbreak of the SARS-CoV-2-induced Coronavirus Disease 2019 (COVID-19) pandemic re-shaped doctor-patient interaction and challenged capacities of healthcare systems. It created many issues around the optimal and safest way to treat complex patients with severe allergic disease. A significant numberof the patients are on treatment with biologicals and clinicians face the challenge to provide optimal care during the pandemic. Read More

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http://dx.doi.org/10.1111/all.14407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300800PMC

New and Emerging Treatments for Inflammatory Itch.

Ann Allergy Asthma Immunol 2020 Jun 1. Epub 2020 Jun 1.

Division of Dermatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO, 63110; Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO, 63110; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, 63110; Center for the Study of Itch and Sensory Disorders, Washington University School of Medicine, St. Louis, MO, 63110. Electronic address:

Objective: Chronic pruritus, or itch lasting >6 weeks, is a common symptom and has a profoundly negative impact on quality of life. While many primary dermatologic disorders such as atopic dermatitis and chronic urticaria are characterized by pruritus, numerous other allergic, hepatobiliary, lymphoproliferative, neurologic, and renal disorders are associated with chronic pruritus. Itch involves complex interactions orchestrated by a variety of factors released from and acting on the skin, immune system, and the sensory nervous system. Read More

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http://dx.doi.org/10.1016/j.anai.2020.05.028DOI Listing

Omalizumab is effective in patients with chronic spontaneous urticaria plus multiple chronic inducible urticaria.

Eur Ann Allergy Clin Immunol 2020 Jun 4. Epub 2020 Jun 4.

I.M. Sechenov First Moscow State Medical University Sechenov University, Division of Immune mediated skin diseases, Moscow, Russian Federation.

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http://dx.doi.org/10.23822/EurAnnACI.1764-1489.153DOI Listing

The Fcε receptor I pathway is crucial but not exclusive for basophil activation in patients with autoimmune forms of chronic spontaneous urticaria.

J Eur Acad Dermatol Venereol 2020 Jun 3. Epub 2020 Jun 3.

ADR-AC GmbH, Adverse Drug Reactions, Analysis and Consulting, Bern, Switzerland.

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http://dx.doi.org/10.1111/jdv.16703DOI Listing

Associations between vitamin D receptor gene polymorphisms and chronic spontaneous urticaria in Chinese Han population.

Postepy Dermatol Alergol 2020 Apr 6;37(2):250-254. Epub 2020 May 6.

Institute of Dermatology, Chinese Academy of Medical Sciences, Nanjing, China.

Introduction: Previous studies found that vitamin D receptor (VDR) TaqI, BsmI, FokI and ApaI gene polymorphisms are associated with several inflammatory diseases. However, the relationship between VDR gene polymorphisms and chronic spontaneous urticaria (CSU) is not clear.

Aim: The purpose of our study was to explore the relationship between the polymorphism of VDR and the incidence of chronic spontaneous urticaria in the Chinese Han population. Read More

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http://dx.doi.org/10.5114/ada.2020.94843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262806PMC

Evaluation of carotid intima media thickness and hematologic inflammatory markers in patients with chronic spontaneous urticaria.

Postepy Dermatol Alergol 2020 Apr 14;37(2):214-220. Epub 2018 Nov 14.

Department of Radiology, Sakarya Training and Research Hospital, Sakarya, Turkey.

Introduction: Low grade inflammation is associated with chronic spontaneous urticaria (CSU) and atherosclerosis. There are little data on the relationship between urticarial inflammation and atherosclerosis. The neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR) and mean platelet volume (MPV) have recently been studied in many diseases as a biomarker of inflammation. Read More

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http://dx.doi.org/10.5114/ada.2018.79567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262809PMC

Urticaria, Angioedema, and Anaphylaxis.

Pediatr Rev 2020 Jun;41(6):283-292

University of Rochester, Rochester, NY.

Urticaria and, to a lesser extent, angioedema are common occurrences in the pediatric population. There are multiple causes of acute and chronic urticaria and angioedema. Most causes are benign, although they can be worrisome for patients and their parents. Read More

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http://dx.doi.org/10.1542/pir.2019-0056DOI Listing

Symptomatic Dermographism: A Systematic Review of Treatment Options.

J Allergy Clin Immunol Pract 2020 May 27. Epub 2020 May 27.

Dermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany. Electronic address:

Background: Symptomatic dermographism (SD), the most common form of chronic inducible urticaria, presents with transient wheals accompanied by itching in response to scratching. Little is known about available treatment options and their efficacy in SD.

Objective: To systematically review the efficacy of treatment options for patients with SD. Read More

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http://dx.doi.org/10.1016/j.jaip.2020.05.016DOI Listing

Flame Figures in Linear Immunoglobulin A Bullous Dermatosis Secondary to Parvovirus B19 Infection.

Am J Dermatopathol 2020 May 28. Epub 2020 May 28.

Departments of Dermatology, and.

Flame figures represent a characteristic but nondiagnostic histological finding in eosinophilic dermatoses. Some bullous autoimmune diseases with a predominant eosinophilic infiltrate, such as bullous pemphigoid, pemphigoid gestationis, and pemphigus vegetans, may show them. However, it is rare to find them in predominant neutrophilic bullous dermatoses such as linear immunoglobulin A. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001690DOI Listing

[Antihistamines for treating pruritus : The end of an era?]

Authors:
E Weisshaar

Hautarzt 2020 Jul;71(7):525-527

Berufsdermatologie, Hautklinik, Universitätsklinikum Heidelberg, Voßstr. 2, 69115, Heidelberg, Deutschland.

Antihistamines, mostly H1 antihistamines, administered both topically and systemically, are among the most widely used drugs. While systemically applicable antihistamines are usually taken orally or administered intravenously, while local therapy is used on the eye, nose or skin. Systemic antihistamines are most frequently used during the pollen season (hay fever, asthma) or are used all year round, e. Read More

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http://dx.doi.org/10.1007/s00105-020-04617-zDOI Listing

The effect of levocetirizine and montelukast on clinical symptoms, serum level and skin expression of COX-1 and COX-2 enzymes in patients suffering from chronic autoimmune urticaria - a pilot study.

Postepy Dermatol Alergol 2020 Feb 23;37(1):73-80. Epub 2018 Nov 23.

Department of Internal Medicine, Asthma and Allergy, Norbert Barlicki Memorial University Hospital No. 1, Medical University of Lodz, Lodz, Poland.

Introduction: Chronic autoimmune urticaria (CAU) lasts over 6 weeks and is characterized by circulating IgE autoantibodies or IgG against IgE or IgE receptor.

Aim: To assess the clinical, laboratory and histological effects of 4-week levocetirizine and montelukast therapy in patients suffering from CAU.

Material And Methods: Of 296 tested patients with chronic urticaria 40 had a positive ASST test. Read More

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http://dx.doi.org/10.5114/ada.2018.79731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247068PMC
February 2020

Omalizumab treatment in adolescents with chronic spontaneous urticaria: Efficacy and safety.

Allergol Immunopathol (Madr) 2020 Jul - Aug;48(4):368-373. Epub 2020 May 25.

Hacettepe University Faculty of Medicine, Department of Pediatric Allergy, 06100 Ankara, Turkey. Electronic address:

Background: Omalizumab is useful as an add-on treatment in patients unresponsive to high doses of second-generation antihistamines. This study aimed to evaluate the efficacy and safety of omalizumab treatment in adolescents with refractory chronic spontaneous urticaria (CSU).

Methods: CSU patients aged 12-18 years old with the diagnosis of symptomatic CSU and unresponsive to classical treatment were included in the study. Read More

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http://dx.doi.org/10.1016/j.aller.2020.03.011DOI Listing

Natural History and Predictors of recovery in Children with Chronic Spontaneous Urticaria.

Pediatr Allergy Immunol 2020 May 27. Epub 2020 May 27.

Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy.

Background: Limited data are available about the natural history of chronic spontaneous urticaria in children (CSU), and management guidelines are mostly extrapolated from evidence in adults.

Methods: The objective of this study was toevaluate the natural history of CSU in children and to identify predictors for remission. We performed an observational study, including patients aged 0 to 18 years with CSU diagnosed from January 2006 to July 2016. Read More

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http://dx.doi.org/10.1111/pai.13299DOI Listing

Gastrointestinal involvement of primary skin diseases.

J Eur Acad Dermatol Venereol 2020 May 26. Epub 2020 May 26.

Center for Research & Development, Kaohsiung Municipal Siaogang Hospital, Kaohsiung, Taiwan.

Less is known about gastrointestinal (GI) involvement of primary skin diseases due to the difference in embryology, histology, microbiology and physiology between integument and alimentary tract. Oesophagus, following the oropharyngeal mucosa, is the most common GI segment affected by primary skin diseases, especially by eosinophilic oesophagitis, lichen planus and autoimmune bullous dermatoses like pemphigus vulgaris, mucosal membrane pemphigoid and epidermolysis bullosa acquisita. Eosinophilic oesophagitis is an emerging chronic atopic disease with oesophageal dysfunction as the typical presentation, and oesophageal narrowing, rings and stricture as late complications. Read More

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http://dx.doi.org/10.1111/jdv.16676DOI Listing

Anxiety, depression, and stress in Korean patients with chronic urticaria.

Korean J Intern Med 2020 May 27. Epub 2020 May 27.

Department of Internal Medicine, Kosin University College of Medicine, Busan, Korea.

Background/aims: Emotional distress is thought to cause or maintain chronic urticaria (CU). We aimed to investigate the presence of anxiety, depression, and stress in Korean adult CU patients and to explore their potential impact on treatment.

Methods: We enrolled 79 CU patients and a disease control group comprising 39 persistent asthma patients. Read More

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http://dx.doi.org/10.3904/kjim.2019.320DOI Listing

Long-term follow-up effect of omalizumab in chronic spontaneous urticaria and its association with serum C-reactive protein levels.

Dermatol Ther 2020 May 23:e13663. Epub 2020 May 23.

Dermatology Department, Istanbul Sultan 2.Abdulhamid Han Training and Research Hospital, Istanbul, Turkey.

This study aims to determine the efficacy of omalizumab, a humanized monoclonal anti-immunoglobulin E antibody, in patients with chronic spontaneous urticaria (CSU) refractory to conventional therapy, together with the evaluation of serum CRP levels. All the patients with a diagnosis of CSU who were continuously treated with omalizumab (300 mg/mo) for at least 3 months between June 2016 and July 2019 were included in this study. Urticaria activity score (UAS-7) was used for assessment of disease activity. Read More

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http://dx.doi.org/10.1111/dth.13663DOI Listing

IgM and IgA in addition to IgG autoantibodies against FcɛRIα are frequent and associated with disease markers of chronic spontaneous urticaria.

Allergy 2020 May 23. Epub 2020 May 23.

Department of Dermatology and Allergy, Dermatological Allergology, Allergie-Centrum-Charité, Charité-Universitätsmedizin Berlin, Germany.

Background: IgG autoantibodies against the high-affinity IgE receptor, FcɛRIα, contribute the pathogenesis of autoimmune chronic spontaneous urticaria (CSU). However, it is not known whether such patients also exhibit IgM or IgA autoantibodies against FcɛRIα. To address this question we developed an ELISA to assess serum levels of IgG, IgM, and IgA autoantibodies against FcɛRIα and investigated whether their presence is linked to clinical features of CSU including the response to autologous serum skin testing (ASST). Read More

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http://dx.doi.org/10.1111/all.14412DOI Listing

Efficacy and Safety of Omalizumab for Chronic Spontaneous Urticaria: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Am J Ther 2020 May 14. Epub 2020 May 14.

Department of Dermatology, Beijing Chao-Yang Hospital, Beijing, China.

Background: Omalizumab has been proposed as a possible effective treatment of chronic spontaneous urticaria (CSU).

Study Question: We aimed to access the efficacy and safety of omalizumab in the treatment of CSU based on qualified, randomized controlled trials (RCTs).

Data Sources: PubMed, the Cochrane library, and Embase databases. Read More

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http://dx.doi.org/10.1097/MJT.0000000000000912DOI Listing

Does adiponectin play a role in the pathogenesis of chronic spontaneous urticaria?

Cent Eur J Immunol 2020 ;45(1):56-59

Department of Internal Diseases, Allergology and Clinical Immunology, School of Medicine with Division of Dentistry in Zabrze, Medical University of Silesia, Poland.

Introduction: Chronic spontaneous urticaria constitutes an interdisciplinary problem and its pathogenesis is still a subject of debate. Overweight and hyperlipidemia are supposed to be related to chronic spontaneous urticaria. Fatty tissue can be the source of adipokines. Read More

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http://dx.doi.org/10.5114/ceji.2020.94678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226560PMC
January 2020

Omalizumab Updosing in Chronic Spontaneous Urticaria: an Overview of Real-World Evidence.

Clin Rev Allergy Immunol 2020 May 16. Epub 2020 May 16.

Department of Dermatology, Hospital del Mar. IMIM, Universitat Autònoma de Barcelona, Barcelona, Spain.

Chronic spontaneous urticaria (CSU) is defined as the spontaneous development of itchy hives and/or angioedema due to known or unknown causes that last for at least 6 weeks. At any given time, CSU is believed to affect 0.5-1% of the global population. Read More

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http://dx.doi.org/10.1007/s12016-020-08794-6DOI Listing

Interleukin-17 is a potential player and treatment target in severe chronic spontaneous urticaria.

Clin Exp Allergy 2020 Jul;50(7):799-804

The Unit of Proteomics and Flow Cytometry, Division of Allergy and Clinical Immunology, Technion, Haifa, Israel.

Background: Chronic spontaneous urticaria (CSU) is considered an autoimmune disorder in 50% of cases at least, in which T- and mast cell mediators are considered to be the primary cause of symptoms. However, H -antihistamines, cyclosporine A, and omalizumab fail to achieve complete symptom amelioration in up to 70% of patients. This suggests that other inflammatory pathways are involved and that additional and more effective treatments need to be developed. Read More

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http://dx.doi.org/10.1111/cea.13616DOI Listing