5,335 results match your criteria Urticaria Chronic


Basophil Activation Test for Allergy Diagnosis.

J Vis Exp 2021 May 31(171). Epub 2021 May 31.

Allergy Unit, Hospital Regional Universitario de Málaga; Allergy Research Group, Instituto de Investigación Biomédica de Málaga-IBIMA; Departamento de Medicina, Universidad de Málaga; Nanostructures for Diagnosing and Treatment of Allergic Diseases Laboratory, Andalusian Center for Nanomedicine and Biotechnology-BIONAND.

The basophil activation test (BAT) is a complementary in vitro diagnostic test that can be used in addition to clinical history, skin test (ST), and specific IgE (sIgE) determination in the evaluation of IgE-mediated allergic reactions to food, insect venom, drugs, as well as some forms of chronic urticaria. However, the role of this technique in the diagnostic algorithms is highly variable and not well determined. BAT is based on the determination of basophil response to allergen/drug cross-linking IgE activation through the measurement of activation markers (such as CD63, CD203c) by flow cytometry. Read More

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Anaphylactic risk related to omalizumab, benralizumab, reslizumab, mepolizumab, and dupilumab.

Clin Transl Allergy 2021 Jun 3;11(4):e12038. Epub 2021 Jun 3.

Department of Pharmacy Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China.

Background: Monoclonal antibodies (mAbs) are novel, effective therapeutics for the treatment of inadequately controlled severe asthma. Knowledge of the anaphylaxis risks related to different mAbs is essential for their appropriate and safe administration. This study aimed to evaluate the associations between different mAbs and anaphylactic reactions by applying statistical approaches to pharmacovigilance data. Read More

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Research on Characteristic of Chronic Spontaneous Urticaria Based on Multiscale Entropy.

Comput Math Methods Med 2021 25;2021:6691356. Epub 2021 May 25.

College of Mathematical Sciences, Harbin Engineering University, Harbin 150001, China.

Chronic spontaneous urticaria (CSU) is a common skin disease which symptom is local pruritus and pain. In medicine, researchers take a certain point that the brain is the control center of CSU, but in previous experiments, the researchers found that cerebellum also had a certain effect on CSU. In order to find out the influence of CSU in the brain and cerebellum, we collected the brain resting-state fMRI data from 40 healthy controls and 32 CSU patients and used DPABI to preprocess. Read More

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In Chronic Spontaneous Urticaria, Comorbid Depression Linked to Higher Disease Activity, and Substance P Levels.

Front Psychiatry 2021 26;12:667978. Epub 2021 May 26.

Department of Dermatology, Koç University School of Medicine, Istanbul, Turkey.

Patients with chronic spontaneous urticaria often exhibit psychiatric comorbidities including depression that contribute to the impairment of their quality of life. How CSU and depression are linked isn't well-understood. Substance P has been shown to be increased in patients with CSU and is held to contribute to the pathogenesis of depression. Read More

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Comparing Antihistamines in Chronic Spontaneous Urticaria: Possible Future Directions.

J Allergy Clin Immunol Pract 2021 Jun;9(6):2272-2273

Médica Sur, Clinical Foundation and Hospital, Mexico City, Mexico; Center of Excellence in Asthma and Allergy, Mexico City, Mexico. Electronic address:

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What's New in the Treatment of Urticaria and Angioedema.

J Allergy Clin Immunol Pract 2021 Jun;9(6):2170-2184

Department for Children and Adolescents, University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, Frankfurt, Germany.

Chronic urticaria and angioedema are diseases often managed by Allergy and Immunology specialists. Recent international guidelines have outlined a stepwise approach to management of patients using dose escalation of second-generation antihistamines followed by use of omalizumab and finally cyclosporine in more refractory cases. In select patients (those with refractory chronic urticaria), nonbiologic alternative medications with anti-inflammatory or immunosuppressant activity may be considered. Read More

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Triggers of Exacerbation in Chronic Urticaria and Recurrent Angioedema-Prevalence and Relevance.

J Allergy Clin Immunol Pract 2021 Jun;9(6):2160-2168

Clinical Faculty, University of Texas Southwestern Medical School, Allergy and Asthma Specialists, Dallas, Texas. Electronic address:

Patients with urticaria and angioedema often have triggers that cause an outbreak or a swelling episode or worsen their chronic condition. Exploring these factors with each patient may result in better understanding and control of their disease. Patients should be advised to avoid known triggers, if feasible, or prepare to prevent or control an exacerbation with appropriate pretreatment if avoidance is not possible. Read More

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How to Measure Disease Activity, Impact, and Control in Patients with Recurrent Wheals, Angioedema, or Both.

J Allergy Clin Immunol Pract 2021 Jun;9(6):2151-2157

Division of Clinical Immunology and Allergy, Department of Medicine, McMaster University, Hamilton, ON, Canada.

Chronic spontaneous urticaria and chronic inducible urticaria are characterized by wheals, angioedema, or both, whereas other conditions such as hereditary angioedema present only with angioedema. The unpredictability of outbreaks, disfigurement, pruritus, and associated sleep and work disturbance can cause a significant impact on quality of life (QoL). Significant breakthroughs in the understanding of these conditions in recent years have led to the development of novel therapies. Read More

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Chronic urticaria in the real-life clinical practice setting in Portugal: 2-years results from the non-interventional multicenter AWARE study.

Acta Med Port 2021 Jun 9. Epub 2021 Jun 9.

Serviço de Imunoalergologia. Centro Hospitalar de Vila Nova de Gaia/Espinho. Vila Nova de Gaia. Portugal.

Introduction: Information regarding chronic urticaria patients in the real-world setting is scarce. This analysis reports the two-year results of Portuguese patients included in the AWARE study.

Material And Methods: Non-interventional cohort study. Read More

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Retrospective Study of Clinico-Aetiological Factors of Chronic Urticaria Among Children Attending a Tertiary Care Paediatric Centre in Eastern Province of Sri Lanka.

Cureus 2021 May 4;13(5):e14848. Epub 2021 May 4.

Paediatrics, Paediatric Professorial Unit, Teaching Hospital, Batticaloa, LKA.

Introduction Chronic urticaria is one of the growing problems worldwide and the prevalence is increasing. Around 2% of children have been shown to be affected with chronic urticaria. Objectives To evaluate demographic, clinical and aetiological factors related to chronic urticaria in children and to assess investigations and treatment. Read More

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Characteristics of patients with chronic spontaneous urticaria showing early and complete responses to omalizumab.

Ann Allergy Asthma Immunol 2021 Jun 5. Epub 2021 Jun 5.

Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

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Knowledge, attitudes, and practices associated with personal health care on urticaria in peripheral health facilities of Yaoundé, Cameroon (Sub-Saharan Africa).

Int J Dermatol 2021 Jun 8. Epub 2021 Jun 8.

Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.

Background: Urticaria is an acute or chronic inflammatory dermatosis that is characterized by erythematous, edematous, itchy, and transient urticarial plaques that cover the skin and mucous membranes. The aim of this study was to evaluate the knowledge of consulting staff on urticaria in Yaoundé, Cameroon, as well as the attitudes and practices resulting from it.

Methods: We conducted a descriptive cross-sectional study. Read More

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Serum level of hemokinin-1 is significantly lower in patients with chronic spontaneous urticaria than in healthy subjects.

Allergol Int 2021 Jun 2. Epub 2021 Jun 2.

Allergy and Immunology Research Project Team, Nihon University School of Medicine, Tokyo, Japan; Center for Medical Education, Nihon University School of Medicine, Tokyo, Japan; Center for Allergy, Nihon University Itabashi Hospital, Tokyo, Japan. Electronic address:

Background: We previously reported upregulation of expression of Mas-related G protein-coupled receptor X2 (MRGPRX2) on mast cells (MCs) in the skin of patients with severe chronic spontaneous urticaria (CSU). Serum levels of substance P (SP) were reportedly significantly elevated, in correlation with the severity of CSU. Hemokinin-1 (HK-1) reportedly induced histamine release from LAD2 cells via MRGPRX2. Read More

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Erratum to "Skin Biopsy in Chronic Urticaria: When and Where and What to Look for?"

Actas Dermosifiliogr 2021 Jun;112(6):570-571

Servicio de Dermatología del Hospital General de Alicante, Alicante, España.

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Effects of Serum Vitamin D Levels and Vitamin D Supplementation on Urticaria: A Systematic Review and Meta-Analysis.

Int J Environ Res Public Health 2021 05 5;18(9). Epub 2021 May 5.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.

(1) Backgrounds: Several studies have shown that the level of 25-hydroxyvitamin D (25(OH)D) could affect urticaria. The association of Vitamin D (VitD) with urticaria has not been well established. (2) Methods: The up-to-date meta-analysis was performed to synthesize the new findings. Read More

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Cold Urticaria. Characterizing the population from an urticaria outpatient clinic.

Actas Dermosifiliogr 2021 May 28. Epub 2021 May 28.

Immunoallergology Department, Hospital de Santa Maria - Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal.

Introduction: Cold Urticaria (ColdU) is a type of chronic inducible urticaria (CIndU) where recurrent pruritic wheals and/or angioedema occur after exposure to cold stimulus. Although it usually only affects exposed areas, systemic reactions can occur in severe cases. In this study, we seek to characterize the ColdU cases within our Centre's population of patients. Read More

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Significant association between Taq1 gene polymorphism in vitamin D receptor and chronic spontaneous urticaria in the Northeast of Iran.

Clin Mol Allergy 2021 May 27;19(1). Epub 2021 May 27.

Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: Chronic spontaneous urticaria (CSU) is defined as urticaria with an unknown etiology which persists for more than 6 weeks. CSU is an uncomfortable cutaneous condition that occurs due to an immune-mediated inflammatory reaction. Many studies have demonstrated that vitamin D deficiency and single-nucleotide polymorphisms in the vitamin D receptor (VDR) impact the immune response. Read More

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Approach to Children with Hives.

Pediatr Ann 2021 May 1;50(5):e191-e197. Epub 2021 May 1.

Urticaria (or hives) is a pruritic and erythematous skin rash. Angioedema commonly occurs with urticaria. The term "chronic urticaria" is used when hives are present for more than 6 weeks. Read More

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What lessons can we learn? Clinical and epidemiological retrospective analysis of 267 patients with urticaria in a Brazilian tertiary center.

An Bras Dermatol 2021 May 21. Epub 2021 May 21.

Department of Dermatology, Centro Universitário Saúde ABC, Santo André, SP, Brazil.

Background: There are few epidemiological studies of urticaria, published in the indexed literature (PubMed/Medline).

Objective: The study aimed to evaluate the epidemiological and clinical data among patients with urticaria/angioedema attending a reference clinic in Brazil.

Methods: Two hundred sixty-seven patients were evaluated retrospectively considering demographic data, time course of the disease, triggering symptoms, the presence of angioedema, complementary laboratory tests including total blood count, reactive-C protein, erythrocyte sedimentation rate, IgE serum levels, and other, as necessary. Read More

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Divergent PGD and leukotriene C metabolite excretion following aspirin therapy: Ten patients with systemic mastocytosis.

Prostaglandins Other Lipid Mediat 2021 Aug 21;155:106563. Epub 2021 May 21.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States.

Aspirin-exacerbated respiratory disease and some cases of chronic idiopathic urticaria are disorders in which increased baseline urinary excretion of leukotriene(LT)E4 further increases following aspirin administration. Increased urinary excretion of the metabolites of prostaglandin D2, 11β-prostaglandin(PG)F2α and (2,3-dinor)-11β-PGF2α, have been documented in systemic mastocytosis (SM) and in mast cell activation syndrome (MCAS). Symptoms due to increased baseline and/or episodic release of PGD2 can be prevented with aspirin, an inhibitor of cyclooxygenase (COX)1 and COX2. Read More

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Remission of a case of multiple Hymenoptera stings-associated chronic urticaria during venom immunotherapy.

Clin Case Rep 2021 May 19;9(5):e04188. Epub 2021 May 19.

General Medicine, Immunology and Allergology Unit IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico Milan Italy.

Hymenoptera stings mostly cause acute urticaria but we describe a case of CU after wasp stings which remitted during venom immunotherapy. IgE-mechanisms have not been fully clarified in CU, except for isolated circumstances. In our case immunotherapy has played a positive role reducing immune cells reactivity and improving urticaria symptoms. Read More

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Effects of pregnancy on chronic urticaria: Results of the PREG-CU UCARE study.

Allergy 2021 May 22. Epub 2021 May 22.

Dermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Urticaria Center of Reference and Excellence (UCARE), Charité - Universitätsmedizin Berlin, Berlin, Germany.

Background: Chronic urticaria (CU) predominantly affects women, and sex hormones can modulate disease activity in female CU patients. As of now, the impact of pregnancy on CU is largely unknown.

Aim: To analyze the course and features of CU during and after pregnancy. Read More

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Effects of a topical treatment with spleen tyrosine kinase inhibitor in healthy subjects and patients with cold urticaria or chronic spontaneous urticaria: Results of a phase 1a/b randomised double-blind placebo-controlled study.

Br J Clin Pharmacol 2021 May 21. Epub 2021 May 21.

Dermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Aims: To explore the safety, tolerability, pharmacokinetics and pharmacodynamics (PD) of GSK2646264 using skin challenge models.

Methods: Healthy volunteers (HV) with a positive allergen skin prick test received GSK2646264 (0.5% or 1% ww) and placebo creams on up to 10% body surface area (BSA). Read More

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Dual biologic therapy in a patient with severe asthma and other allergic disorders.

BMJ Case Rep 2021 May 20;14(5). Epub 2021 May 20.

Section of Allergy/Immunology, Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana, USA

Severe asthma is very difficult to manage in many individuals, and systemic corticosteroids are often used to prevent or manage acute exacerbations. Furthermore, comorbid allergic conditions may render standard therapies inadequate. A 51-year-old man presented with severe eosinophilic asthma requiring nearly constant oral corticosteroid usage despite using high-dose inhaled corticosteroids and secondary asthma controllers. Read More

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Forewarned is Forearmed: chronic spontaneous urticaria as a potential risk to effective SARS-COV-2 vaccine uptake and global public health.

Br J Dermatol 2021 May 20. Epub 2021 May 20.

Department Allergy and Immunology, University Hospitals Birmingham, Birmingham, UK.

Chronic spontaneous urticaria and angioedema (CSU/A) is a common condition with an estimated global point prevalence of 0.7% (95% C.I, 0. Read More

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Effectiveness of Omalizumab in Patients with Chronic Inducible Urticaria: real-life experience from two UCARE centres.

J Eur Acad Dermatol Venereol 2021 May 20. Epub 2021 May 20.

Department of Dermatology, Koç University School of Medicine, Istanbul, Turkey.

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Lower IgA Levels in Chronic Spontaneous Urticaria Are Associated With Lower IgE Levels and Autoimmunity.

Front Immunol 2021 3;12:657211. Epub 2021 May 3.

Dermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Background: The pathogenesis of chronic spontaneous urticaria (CSU) is still insufficiently understood. Recent findings suggest that immunoglobulins, in particular IgE but also IgA, play a role in the development of CSU.

Objective: Our aim was to assess differences in clinical and laboratory markers between CSU patients with and without lower levels of serum IgA and IgE. Read More

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[Medicaments and oral healthcare. Medicaments potentially inducing angioedema and/or urticaria].

Ned Tijdschr Tandheelkd 2021 May;128(5):269-276

Angioedema stems from increased vasodilation and vascular permeability, resulting in extravasation of fluid. Hereditary and acquired types of angioedema can be distinguished, with 3 and 4 subtypes, respectively. Groups of medicaments potentially inducing angioedema are, among others: ACE inhibitors, angiotensin II receptor blockers, dipeptidyl peptidase-4 inhibitors, thrombocyte aggregation inhibitors and immunosuppressive agents. Read More

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The Role of Interleukin 10 and 18 in Chronic Spontaneous Urticaria Pathogenesis in the Context of Angioedema Coexistence.

J Interferon Cytokine Res 2021 May;41(5):172-176

Department of Internal Medicine with Division of Allergology, Institute of Medical Sciences, University of Opole, Opole, Poland.

Chronic spontaneous urticaria (CSU) is defined using clinical symptoms as spontaneous occurrence of itchy wheals and/or angioedema for at least 6 weeks. Angioedema is underdiagnosed in CSU patients, and its presence has significant negative impact on health-related quality of life, daily activities, health care resource utilization, and work. Various cytokines have been found to be involved in pathogenesis of CSU. Read More

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Improvement of patient outcomes following therapeutic optimization of chronic urticaria: two-year data from France as part of the international real-life AWARE study.

Eur J Dermatol 2021 Apr;31(2):217-224

Dermatologie et Dermato-allergologie, CHU de Poitiers, Poitiers, France.

Background: It is important to assess the burden of chronic urticaria (CU) with real-life studies. The AWARE study was performed in 36 countries over two years in CU patients resistant to H1-antihistamines.

Objectives: To correlate patient-reported outcomes and available therapeutic options in CU patients. Read More

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