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    1 OF 90

    Prevalence and Clinical Characteristics of Chronic Spontaneous Urticaria in Pediatric Patients.
    Pediatr Allergy Immunol 2018 Apr 21. Epub 2018 Apr 21.
    Charité - Universitätsmedizin Berlin, Department of Dermatology and Allergy, Berlin, Germany.
    Background: Data on the prevalence and disease management of chronic urticaria (CU) and chronic spontaneous urticaria (CSU) in the pediatric population are scarce. The present study assessed the prevalence of CU and CSU, and disease management among pediatric patients (0-17 years).

    Methods: A physician-based online survey was conducted in 5 European countries (United Kingdom, Germany, Italy, France, and Spain) assessing the annual diagnosed prevalence, disease characteristics and treatment patterns in the target population. Read More

    The basophil proteome in chronic spontaneous urticaria distinguishes responders to omalizumab from non-responders.
    Clin Exp Allergy 2018 Apr 19. Epub 2018 Apr 19.
    Division of Allergy and Clinical Immunology Departments of Medicine and Immunology, University of Colorado Denver School of Medicine, Aurora, CO.
    Chronic spontaneous urticaria (CSU) is a disease of unknown etiology in which urticarial lesions are present for 6 weeks or more, without an apparent trigger. Although the pathophysiology of the condition is unclear, there is a documented association between disease activity and blood basophil number and function. CSU patients are basopenic, and those with the most severe symptoms have the lowest number of basophils. Read More

    Diagnosis, pathogenesis, and treatment of chronic spontaneous urticaria.
    Allergy Asthma Proc 2018 May;39(3):184-190
    Background: Chronic Spontaneous Urticaria (CSU) is an endogenous disorder that is strongly associated with autoimmunity, particularly with immunoglobulin G (IgG) antibody to the alpha subunit of the IgE receptor seen in 35-40% of patients. Basophils and cutaneous mast cells can be activated and lead to a late-phase-like perivascular infiltration about small venules and hive formation.

    Methods: Review of current literature. Read More

    Associations of chronic urticaria with atopic and autoimmune comorbidities: a nationwide population-based study.
    Int J Dermatol 2018 Apr 16. Epub 2018 Apr 16.
    Department of Health Services Administration, China Medical University, Taichung, Taiwan.
    Background: Most cases of chronic urticaria (CU) are idiopathic. Circumstantial evidence suggests that some CU cases have an autoimmune pathogenesis. Previous research indicates that a substantial percentage of patients with CU have an atopic background. Read More

    Predicting Chronic Spontaneous Urticaria Symptom Return after Omalizumab Treatment Discontinuation: Exploratory Analysis.
    J Allergy Clin Immunol Pract 2018 Apr 12. Epub 2018 Apr 12.
    Novartis Pharma AG, Basel, Switzerland.
    Background: Omalizumab is highly effective in controlling chronic spontaneous urticaria (CSU) symptoms; however, patients can experience symptom return upon treatment discontinuation. Pivotal clinical trials have identified two categories of patients who experience symptom return: rapid and slow.

    Objective: To identify potential predictors of the speed of symptom return after stopping omalizumab treatment. Read More

    The protective effect of Lactobacillus and Bifidobacterium as the gut microbiota members against chronic urticaria.
    Int Immunopharmacol 2018 Apr 11;59:168-173. Epub 2018 Apr 11.
    Department of Microbiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran. Electronic address:
    Background: Chronic Urticaria is a common disorder which is defined by recurrent occurrence of wheals and sometimes angioedema. It has a notable influence on the patients' quality of life. Regulation of the immune system is one of the important roles of the gut microbiota. Read More

    A case of atopic dermatitis caused by infection.
    Clin Mol Allergy 2018 10;16:10. Epub 2018 Apr 10.
    3School and Operative Unit of Allergy and Clinical Immunology Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
    Background: Parasite infections stimulate total and specific IgE production that, in the case of infection, corresponds to chronic allergic symptoms. There may also be other infections which have similar symptoms, such as infection. is a large nematode that causes abdominal pain, nausea, vomiting, bloating, anorexia and intermittent diarrhoea. Read More

    High-dose antihistamines for chronic spontaneous urticaria in adults.
    • Authors:
    Drug Ther Bull 2018 Apr;56(4):45-48
    Chronic spontaneous urticaria (CSU) is a common skin disease characterised by intermittent weals (hives), angioedema or both lasting for at least 6 weeks.1-3 Second-generation antihistamines are widely used to manage symptoms but are not completely effective in many patients at licensed doses.4 Some guidelines recommend off-label use of high-dose antihistamines as the next therapeutic step. Read More

    Rituximab in Refractory Chronic Spontaneous Urticaria: An Encouraging Therapeutic Approach.
    Skin Pharmacol Physiol 2018 Apr 12;31(4):184-187. Epub 2018 Apr 12.
    Dermatology Unit, Hospital Clinic de Barcelona, Barcelona, Spain.
    Background: Chronic spontaneous urticaria (CSU) is a frequent mast cell-driven disease that affects approximately 0.5-1% of the population. Antihistamines are currently the drugs of choice in patients with CSU. Read More

    Clinical Features of Chronic Spontaneous Urticaria that Predict Disease Prognosis and Refractoriness to Standard Treatment.
    Acta Derm Venereol 2018 Apr 12. Epub 2018 Apr 12.
    Department of Dermatology, Hospital del Mar, Parc de Salut Mar, Passeig Marítim 25-29, ES-08003 Barcelona, Spain.
    Chronic spontaneous urticaria (CSU) is characterized by heterogeneous activity, evolution, associated comorbidities and response to treatment. The aim of this study was to identify prognostic factors in patients with CSU that predict disease course and response to standard treatments. An observational retrospective study was conducted in a cohort of 549 patients with CSU, comparing patients with isolated CSU and those with CSU with concomitant inducible urticaria (CSU-CIndU). Read More

    Chronic urticaria in a health maintenance organization of Buenos Aires, Argentina - new data that increase global knowledge of this disease.
    An Bras Dermatol 2018 Jan-Feb;93(1):76-79
    Department of Dermatology. Hospital del Mar. Institut Mar d'Investigacions mèdiques. Universitat Autònoma - Barcelona, Spain.
    Background: In spite of the frequency of chronic urticaria, there are no epidemiological studies on its prevalence in Argentina.

    Objective: The objective of this study was to define the prevalence and epidemiological characteristics of chronic urticaria patients in Buenos Aires.

    Methods: The population studied were the members of the Italian Hospital Medical Care Program, a prepaid health maintenance organization located in the urban areas around the Autonomous City of Buenos Aires, Argentina. Read More

    New biologics for allergic diseases.
    Expert Rev Clin Immunol 2018 Apr 10;14(4):285-296. Epub 2018 Apr 10.
    b The Cohen Family Asthma Institute, Division of Pulmonary, Critical Care, and Sleep Medicine , National Jewish Health , Denver , CO , USA.
    Introduction: Allergic conditions such as asthma and atopic dermatitis have a high prevalence but represent a heterogeneous group of diseases despite similar clinical presentation and underlying pathophysiology. A better understanding of the phenotypes and endotypes of these diseases has driven rapid development of biologic medications targeting many steps of the inflammatory pathways. Areas covered: There are 2 major inflammatory pathways that drive allergic diseases: Type-2 (Th-2) inflammation and non-type 2 inflammation. Read More

    A Histamine-Free Diet Is Helpful for Treatment of Adult Patients with Chronic Spontaneous Urticaria.
    Ann Dermatol 2018 Apr 21;30(2):164-172. Epub 2018 Feb 21.
    Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
    Background: In adult patients with chronic urticaria (CU), the prevalence of food allergy is low compared to childhood patients. However, there are many patients who report food-related aggravation of CU, and some of them may have histamine intolerance.

    Objective: The aim of this study was to evaluate the role of ingested histamine and to investigate the effect of a histamine-free diet in adult patients with CU. Read More

    Epidemiology of urticaria in Poland - nationally representative survey results.
    Postepy Dermatol Alergol 2018 Feb 20;35(1):67-73. Epub 2018 Feb 20.
    Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, Poland.
    Introduction: The prevalence of urticaria is 15-20%. Women are twice as likely to be affected.

    Aim: To present the epidemiology of urticaria and angioedema in Poland. Read More

    An ELISA Assay for Quantifying Monomeric C-Reactive Protein in Plasma.
    Front Immunol 2018 12;9:511. Epub 2018 Mar 12.
    MOE Key Laboratory of Environment and Genes Related to Diseases, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China.
    Native C-reactive protein (nCRP) is a non-specific marker of inflammation being claimed as a bystander in several chronic disorders. Accumulating evidence indicates that nCRP dissociates to and acts primarily as the monomeric conformation (mCRP) at inflammatory loci. This suggests that mCRP may be a superior disease marker with improved specificity and clear causality to the underlying pathogenesis. Read More

    IgE and D-dimer baseline levels are higher in responders than non-responders to omalizumab in chronic spontaneous urticaria.
    Br J Dermatol 2018 Mar 27. Epub 2018 Mar 27.
    Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, UOC Dermatologia, IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico, Milano, Italy.
    Recently, it has been demonstrated that IgE levels may predict the clinical response to omalizumab treatment in chronic spontaneous urticaria (CSU) patients . The authors showed that baseline total IgE levels and notably the ratio between their levels at week 4 of treatment and baseline are predictors of response to omalizumab in CSU . In another recent study, IgE levels before treatment have been shown to be inversely proportional to CSU relapse time after omalizumab discontinuation . Read More

    Benefit of mepolizumab treatment in a patient with chronic spontaneous urticaria.
    J Dtsch Dermatol Ges 2018 Apr 26;16(4):477-478. Epub 2018 Mar 26.
    Allergie-Centrum-Charité, Urticaria Center of Reference and Excellence (UCARE), Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin.

    The Dysfunction of the Cerebellum and Its Cerebellum-Reward-Sensorimotor Loops in Chronic Spontaneous Urticaria.
    Cerebellum 2018 Mar 24. Epub 2018 Mar 24.
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
    Chronic spontaneous urticaria (CSU) is a common itchy skin disease. Despite its prevalence, the neuropathology of CSU is uncertain. In this study, we explored resting state functional connectivity (rs-FC) changes in CSU, as well as how the symptom changes following intervention can modulate rs-FC. Read More

    Validity and responsiveness of the urticaria activity and impact measure (U-AIM), a new patient-reported tool.
    Ann Allergy Asthma Immunol 2018 Mar 19. Epub 2018 Mar 19.
    Genentech, Inc., South San Francisco, CA.
    Background: Chronic spontaneous urticaria (CSU), also known as chronic idiopathic urticaria (CIU), may produce hives, itch, and angioedema. The Urticaria Activity and Impact Measure (U-AIM) is a newly developed 9-item patient-reported measure designed for use in routine clinical practice to assess CSU activity and impact over the previous 7 days.

    Objective: To evaluate validity, responsiveness, and clinically meaningful change of the U-AIM. Read More

    Gastritis Can Cause and Trigger Chronic Spontaneous Urticaria Independent of the Presence of Helicobacter pylori.
    Int Arch Allergy Immunol 2018 22;175(4):246-251. Epub 2018 Mar 22.
    Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Dermatology and Allergy, Allergy Center Charité, Berlin, Germany.
    Background/aim: In chronic spontaneous urticaria (CSU), Helicobacter pylori (HP) has been discussed as a cause, but it is unknown whether the bacterium itself or concomitant inflammation is causing the urticaria. Our aim was to investigate HP and upper gastrointestinal lesions as signs of inflammation independently of each other in the pathogenesis of CSU.

    Methods: A total of 36 prospectively enrolled CSU patients from Moscow were investigated by gastroscopy and screened for the presence of HP and/or upper gastrointestinal lesions. Read More

    Management of Pediatric Urticaria with Review of the Literature on Chronic Spontaneous Urticaria in Children.
    J Allergy Clin Immunol Pract 2018 Mar 14. Epub 2018 Mar 14.
    St John's Institute of Dermatology, Guy's Hospital, London, United Kingdom.
    There are substantial knowledge gaps related to diagnosis and management of pediatric cases of chronic urticaria, and in particular chronic spontaneous urticaria (CSU). In this article we aimed to review the diagnosis and management of chronic urticaria in children and CSU in particular. We conducted a systematic review of articles published in English and French on pediatric CSU management in the last 10 years. Read More

    Refractory Abdominal Pain in a Patient with Chronic Lymphocytic Leukemia: Be Wary of Acquired Angioedema due to C1 Esterase Inhibitor Deficiency.
    Case Rep Hematol 2018 10;2018:7809535. Epub 2018 Jan 10.
    Department of Medicine, Reading Hospital, West Reading, PA, USA.
    Acquired angioedema due to C1 inhibitor deficiency (C1INH-AAE) is a rare and potentially fatal syndrome of bradykinin-mediated angioedema characterized by episodes of angioedema without urticaria. It typically manifests with nonpitting edema of the skin and edema in the gastrointestinal (GI) tract mucosa or upper airway. Edema of the upper airway and tongue may lead to life-threatening asphyxiation. Read More

    Solar urticaria in 145 patients: Assessment of action spectra and impact on quality of life in adults and children.
    Photodermatol Photoimmunol Photomed 2018 Mar 13. Epub 2018 Mar 13.
    Centre for Dermatology Research, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester and Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
    Background: Solar urticaria (SU) is a rare chronic inducible urticaria triggered via uncharacterized chromophores. We detail responses of a large patient series to monochromator phototesting and broadband ultraviolet radiation (UVR); relationship to life quality is explored.

    Methods: Retrospective review of all SU patients undergoing standardized diagnostic photoinvestigation at a specialist centre during 2000-2016. Read More

    Histamine-release test in angioedema patients without urticaria - a retrospective co-hort study of 404 patients.
    Eur Ann Allergy Clin Immunol 2018 Feb 19. Epub 2018 Feb 19.
    Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Den-mark.
    Summary: A subset of patients with angioedema (AE) and urticaria has histamine releasing autoanti-boies. The histamine release test (HR-test) has been used as a tool in chronic urticaria to de-fine the autoimmune subgroup and may possibly guide the clinician to a more personalized therapy, like omalizumab and cyclosporine. The prevalence and value of positive histamine releasing autoantibodies in monosymptomatic AE is sparsely described in the literature. Read More

    The Effect of Autologous Serum Therapy in Chronic Spontaneous Urticaria Depends on Autologous Serum Skin Test Positivity.
    Egypt J Immunol 2017 Jun;24(2):165-172
    Department of Medical Microbiology & Immunology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
    Chronic spontaneous urticaria (CSU) is a common distressing disease caused mainly by autoreactive mechanisms. Autologous serum therapy (AST) has been tried for treatment of many autoimmune diseases including chronic urticaria. We assessed the effect of AST in autologous serum skin test (ASST)-positive and ASST-negative CSU patients. Read More

    Omalizumab for Management of Refractory Urticaria: Experience of a Tertiary Care Centre in Eastern India.
    Indian J Dermatol 2018 Jan-Feb;63(1):66-69
    Department of Dermatology, INHS Asvini, Mumbai, Maharashtra, India.
    Aim: To study the effects of omalizumab in chronic spontaneous urticaria in Indian patients.

    Setting And Design: The study was conducted in a tertiary care centre and it was retrospective and descriptive in nature.

    Material And Methods: We analysed the data of patients who were administered omalizumab between June 2014 and June 2015 for the management of refractory chronic spontaneous urticaria at our centre. Read More

    Consensus Statement for the Diagnosis and Treatment of Urticaria: A 2017 Update.
    Indian J Dermatol 2018 Jan-Feb;63(1):2-15
    Department of Dermatology, Krupa Shankar Skin Care Center, Mallige Hospital, Bengaluru, Karnataka, India.
    This article is developed by the Skin Allergy Research Society of India for an updated evidence-based consensus statement for the management of urticaria, with a special reference to the Indian context. This guideline includes updated definition, causes, classification, and management of urticaria. Urticaria has a profound impact on the quality of life and causes immense distress to patients, necessitating effective treatment. Read More

    Contact dermatitis and patch testing for the allergist.
    Ann Allergy Asthma Immunol 2018 Mar 6. Epub 2018 Mar 6.
    Allergy and Immunology Fellow, NYU Winthrop Hospital, Mineola, New York.
    Objective: Contact dermatitis (CD) is a common disease seen by allergists. Although underutilized, patch testing (PT) remains the gold standard in the diagnosis of allergic CD. It is not difficult to perform, however, the interpretation of the PT, proper classification of the results and determination of their relevance, need an appropriate level of expertise. Read More

    Chronic urticaria can be caused by cancer and resolves with its cure.
    Allergy 2018 Mar 8. Epub 2018 Mar 8.
    Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Germany.
    We present 26 cases (ours and 25 from an extended literature review) in which chronic spontaneous urticaria (CSU) seems to be caused by a malignancy (mostly carcinoma or hematologic malignancy): the CSU precedes the neoplasia diagnosis by some months (2-8mo in 80%) and resolved days after chemotherapy/ surgical resection of the malignancy. In three patients, the urticaria flare-up alerted the treating physician of neoplasia recurrence. There could be publication bias, but the narrow time-span between cancer remission and urticaria resolution and especially the recurrence of urticaria that led to detection of cancer relapse in some of our cases are arguments in favor of a causal relationship. Read More

    Health care burden and treatment patterns in commercially insured children with chronic idiopathic/spontaneous urticaria: A real-world study in the United States.
    Allergy Asthma Proc 2018 May 7;39(3):201-211. Epub 2018 Mar 7.
    Herbert Wertheim School of Medicine, Florida International University, Miami, Florida.
    Background: Chronic idiopathic urticaria (CIU)/spontaneous urticaria (CSU) is defined by the presence of wheals, angioedema, or both for ≥6 weeks, with or without an identifiable trigger. Real-world health care data among children with CIU/CSU remain scarce.

    Objectives: To describe treatment patterns, health care resource utilization (HRU), and costs in pediatric patients with CIU/CSU (<12 years old) and to compare these with pediatric patients without CIU/CSU. Read More

    Omalizumab in elderly patients with chronic spontaneous urticaria: An Italian real-life experience.
    Ann Allergy Asthma Immunol 2018 Mar;120(3):318-323
    Department of Internal Medicine and Clinical Pathology, Azienda Ospedaliera Universitaria Federico II, Naples, Italy. Electronic address:
    Background: Omalizumab therapy is effective and safe in patients with chronic spontaneous urticaria (CSU) resistant to nonsedating histamine (H) antihistamines (nsAHs).

    Objective: To evaluate the efficacy and safety of omalizumab in elderly (aged ≥65 years) patients with nonsedating H-antihistamine-refractory CSU in a real-life setting.

    Methods: Patients with nonsedating H-antihistamine-refractory CSU (n = 322) treated with omalizumab administered every 4 weeks in doses of 300 mg for 24 weeks were divided into 2 groups according to age at omalizumab treatment onset: 15 to 64 years and 65 years or older. Read More

    Involvement of new oxidative stress markers in chronic spontaneous urticaria.
    Postepy Dermatol Alergol 2017 Oct 31;34(5):448-452. Epub 2017 Oct 31.
    School and Division of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, "G. Martino" University Hospital, Messina, Italy.
    Introduction: Oxidative stress is a result of an imbalance between endogenous production of free reactive oxygen species and reduced effectiveness of antioxidant defence mechanisms. Advanced glycation end products (AGEs) and advanced oxidation protein products (AOPPs) are compounds formed by transformation of macromolecules, including proteins which can serve as markers of oxidative stress and inflammation in several diseases.

    Aim: To investigate the role of AGEs and AOPPs as new markers of oxidative stress and inflammation in patients with chronic spontaneous urticaria (CSU). Read More

    [NLRC4 associated autoinflammatory diseases: A systematic review of the current literature].
    Rev Med Interne 2018 Apr 26;39(4):279-286. Epub 2018 Feb 26.
    Service de médecine interne, hôpital Tenon, université Paris 6, Pierre-et-Marie-Curie (UPMC), Assistance publique-hôpitaux de Paris (AP-HP), 4, rue de la Chine, 75020 Paris, France; Centre de référence des maladies auto-inflammatoires et de l'amylose inflammatoire (CEREMAIA), hôpital Tenon, 75020 Paris, France; Inserm UMRS_933, hôpital Trousseau, université Pierre-et-Marie-Curie (UPMC) - Paris 6, Assistance publique-hôpitaux de Paris, 26, avenue du Dr Arnold Netter, 75012 Paris, France. Electronic address:
    The auto-inflammatory diseases linked to NLRC4 mutations are recently described entities. Transmission is autosomal dominant in 80 % of cases; cases of somatic mutation have already been reported. The disease may display two very different clinical phenotypes: the phenotype 1 (30 %), severe, is dominated by a multisystemic inflammation starting in the first year of life with symptoms of chronic inflammatory bowel disease (IBD), macrophagic actication syndrome (MAS), or even a presentation suggesting a cryopyrinopathy in its CINCA form; the mortality of this phenotype is high (25 %). Read More

    Chronic urticaria and thyroid autoimmunity: a perplexing association.
    Oxf Med Case Reports 2018 Feb 22;2018(2):omx099. Epub 2018 Feb 22.
    Imperial College London, London SW7 2AZ, UK.
    Chronic urticaria has long been thought to be associated with autoimmune conditions, in particular autoimmune thyroid disease (AITD). We detail an unusual case of a 49-year-old patient presenting with urticaria distributed on both shins and hands, with no known associated triggers, and subsequently diagnosed with AITD. The urticaria resolved upon treatment of the AITD. Read More

    Association of alopecia areata with atopic dermatitis and chronic spontaneous urticaria.
    Allergy Asthma Proc 2018 Mar;39(2):96-102
    From the Leumit Health Services, Tel-Aviv, Israel.
    Background: Epidemiologic studies report that alopecia areata (AA) is related to various atopic and autoimmune diseases. The purpose of this study was to identify clinical characteristics and the prevalence of comorbid conditions in Israeli patients with AA.

    Methods: This retrospective, matched, case-control study was based on data from an electronic patient record data base. Read More

    Association between urticaria and nematode infections.
    Allergy Asthma Proc 2018 Mar;39(2):86-95
    From the School and Division of Allergy and Clinical Immunology, Department of Clinical and Experimental Medicine, University Hospital "G. Martino," Messina, Italy.
    Background: The association between parasites and urticaria was first suggested in the last century. A wide range, 0-75.4%, of the prevalence of parasitic infection has been reported with chronic urticaria (CU). Read More

    Omalizumab in chronic spontaneous and inducible urticaria: a 9 year retrospective study in Portugal.
    Eur Ann Allergy Clin Immunol 2018 Jan 16. Epub 2018 Jan 16.
    Immunoallergology Department, Santa Maria Hospital, Centro Hospitalar Lisboa Norte, Lisbon, Portugal.
    Summary: Describe the safety and long-term use of omalizumab in chronic urticaria (CU), both spontaneous (CSU) and inducible (CIndU). Retrospective chart-review (2006-15) of CU patients treated with omalizumab for ≥ 6 months. Statistical analyses: descriptive statistics, Mann-Whitney, generalized linear models. Read More

    Cost-effectiveness of omalizumab for the treatment of Chronic Spontaneous Urticaria.
    Br J Dermatol 2018 Feb 24. Epub 2018 Feb 24.
    Institute for Medical Technology Assessment, Erasmus University Rotterdam, PO Box 1738, 3000 DR, Rotterdam, the Netherlands.
    Background: Chronic spontaneous urticaria (CSU) is a skin disease, with itchy hives and / or angioedema that last for at least 6 weeks without an obvious external trigger.

    Objectives: The objective of this study was to determine the cost-effectiveness of omalizumab relative to standard of care (SoC; up to 4 times the daily dose of H1-antihistaminics) for the Netherlands from a societal perspective.

    Methods: The Markov model used consisted of five health states based on Urticaria Activity Score over seven days (UAS7). Read More

    Schnitzler syndrome in a patient with a family history of monoclonal gammopathy.
    Dermatol Online J 2018 Jan 15;24(1). Epub 2018 Jan 15.
    University of Texas Health Science Center, McGovern Medical School, Houston, Texas Department of Dermatology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
    Schnitzler syndrome is a rare disease characterized by chronic urticaria and a monoclonal gammopathy, most commonly IgM with light chains of the kappa type. There are currently no known risk factorsassociated with development of the disease. We report a case of Schnitzler syndrome in a 48-year-old man with a family history of monoclonal gammopathies. Read More

    Bilastine safety in drivers who need antihistamines: new evidence from high-speed simulator driving test on allergic patients.
    Eur Rev Med Pharmacol Sci 2018 Feb;22(3):820-828
    Department of Surgical, Medical, Dental and Morphological Sciences with Interest in Transplant, Oncological and Regenerative Medicine; Dermatology Unit; University of Modena and Reggio Emilia, Modena, Italy.
    Objective: Bilastine is a highly selective, non-sedating antihistamine, indicated for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria. Available data suggest that bilastine interferes neither with driving ability nor with flying-related performance. However, no data are available on the effect of bilastine on the driving ability in extreme conditions. Read More

    Angioedema in Chronic Spontaneous Urticaria Is Underdiagnosed and Has a Substantial Impact: Analyses From ASSURE-CSU.
    Allergy 2018 Feb 20. Epub 2018 Feb 20.
    Novartis Pharma AG, Basel, Switzerland.
    Background: ASSURE-CSU revealed differences in physician and patient reporting of angioedema. This post-hoc analysis was conducted to evaluate the actual rate of angioedema in the study population and explore differences between patients with and without angioedema.

    Methods: This international observational study assessed 673 patients with inadequately controlled chronic spontaneous urticaria (CSU). Read More

    Real-world use of omalizumab in patients with chronic idiopathic/spontaneous urticaria in the United States.
    Allergy Asthma Proc 2018 May 19;39(3):191-200. Epub 2018 Feb 19.
    Bernstein Clinical Research Center, Cincinnati, Ohio.
    Background: Omalizumab was approved for the treatment of chronic idiopathic urticaria (CIU)/chronic spontaneous urticaria (CSU) in the United States in March 2014.

    Objective: This study sought to describe real-world omalizumab use, in the United States, in a large cohort of patients with CIU/CSU.

    Methods: Patients with CIU/CSU (ages ≥12 years) initiated on omalizumab (index date) with ≥12 months of pre- and postindex data were identified in the an insurance claims data base (January 1, 2013, to July 31, 2016). Read More

    Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development.
    J Med Chem 2018 Mar 23;61(6):2227-2245. Epub 2018 Feb 23.
    Genentech, Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
    Bruton's tyrosine kinase (Btk) is a nonreceptor cytoplasmic tyrosine kinase involved in B-cell and myeloid cell activation, downstream of B-cell and Fcγ receptors, respectively. Preclinical studies have indicated that inhibition of Btk activity might offer a potential therapy in autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. Here we disclose the discovery and preclinical characterization of a potent, selective, and noncovalent Btk inhibitor currently in clinical development. Read More

    Chronic inducible urticaria: A systematic review of treatment options.
    J Allergy Clin Immunol 2018 Feb 10. Epub 2018 Feb 10.
    Department of Dermatology, Venerology and Allergy, Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. Electronic address:
    Background: Chronic inducible urticaria (CindU) is a condition characterized by the appearance of recurrent wheals, angioedema, or both as a response to specific and reproducible triggers.

    Objective: We sought to systematically assess evidence on the efficacy and safety of treatment options for CindU. Results were used to inform the 2017 update of "The EAACI/GALEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria. Read More

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