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    [Diagnostic and Therapeutic Approach of Chronic Spontaneous Urticaria: Recommendations in Portugal].
    Acta Med Port 2016 Nov 30;29(11):763-781. Epub 2016 Nov 30.
    Serviço de Dermatologia. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal; Clínica de Dermatologia. Faculdade de Medicina. Universidade de Coimbra. Coimbra. Portugal.
    Chronic spontaneous urticaria is a complex disorder, of unclear etiology, easily diagnosed although often difficult to treat. It has a significant impact on the patients' quality of life and results in high direct and indirect costs. The diagnosis of chronic spontaneous urticaria is mainly clinical and a limited number of tests is recommended for differential diagnosis and/or for the investigation/exclusion of possible causes. Read More

    Omalizumab for the Treatment of Chronic Idiopathic Urticaria: Systematic Review of the Literature.
    Pharmacotherapy 2017 Feb 22. Epub 2017 Feb 22.
    Institute of Applied Sciences and Intelligent Systems "Eduardo Caianiello" (ISASI), National Research Council of Italy (CNR), via Torre Bianca, Mortelle, 98164, Messina, Italy.
    Omalizumab is recombinant humanized monoclonal antibody to immunoglobulin E. Guidelines for the treatment of chronic idiopathic urticaria (also known as chronic spontaneous urticaria) recommend the use of omalizumab as third-line therapy in addition to high doses of histamine receptor type 1 (H1 ) antihistamines when they are unsuccessful as first- and second-line therapy. We performed a systematic review of the literature to identify studies that evaluated the efficacy of omalizumab for the treatment of chronic idiopathic urticaria, both in controlled and real-world settings, to assess its potential role as a preferred therapy. Read More

    Management of Chronic Spontaneous Urticaria in Routine Clinical Practice Following the EAACI/GA(2)LEN/EDF/WAO Guidelines.
    Actas Dermosifiliogr 2017 Feb 17. Epub 2017 Feb 17.
    Servicio de Dermatología, Hospital General Universitario de Alicante, Alicante, España.
    Introduction: Chronic spontaneous urticaria is a prevalent and difficult-to-treat condition that has a very negative impact on patient quality of life.

    Objective: To describe the epidemiological and clinical characteristics of patients presenting with chronic spontaneous urticaria and the response to treatment administered according to the EAACI/GA(2)LEN/EDF/WAO consensus guideline.

    Material And Method: Descriptive cross-sectional study of all the patients with chronic spontaneous urticaria who consulted a skin allergy unit in the dermatology department of a tertiary hospital in Spain between July 2011 and July 2015. Read More

    D-Dimer Plasma Levels Parallel the Clinical Response to Omalizumab in Patients with Severe Chronic Spontaneous Urticaria.
    Int Arch Allergy Immunol 2017 Feb 21;172(1):40-44. Epub 2017 Feb 21.
    Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Italy.
    Omalizumab is very effective in the majority of patients with severe chronic spontaneous urticaria (CSU), but its mechanism of action is still unclear. In CSU the coagulation cascade is activated with an intensity that parallels the disease severity, and elevated plasma D-dimer levels are associated with a poor response to both antihistamines and cyclosporin. We measured D-dimer plasma levels before and after the first administration of omalizumab in 32 patients with severe CSU. Read More

    Synergistic Actions of Histamine-Releasing Factor and Histamine Releasing Factor-Reactive IgE in Chronic Urticaria.
    Int Arch Allergy Immunol 2017 Feb 21;172(1):27-32. Epub 2017 Feb 21.
    The etiology of chronic urticaria (CU) remains elusive. Histamine-releasing factor (HRF) is reported to have a proinflammatory role in asthma and immediate hypersensitivity of the skin. The aim of this study was to examine the role of HRF in the pathogenesis of CU. Read More

    Elevated Nitrosative Stress in Children with Chronic Spontaneous Urticaria.
    Int Arch Allergy Immunol 2017 Feb 21;172(1):33-39. Epub 2017 Feb 21.
    Departments of Pediatric Allergy and Immunology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
    Background: Chronic spontaneous urticaria (CSU) is an idiopathic condition that seriously affects quality of life. It is well known that oxidative stress and nitrosative stress (NS) are generally involved in many chronic inflammatory diseases. This study aimed to evaluate the possible role of NS in the pathogenesis of CSU. Read More

    Food Protein-Induced Enterocolitis Syndrome.
    J Investig Allergol Clin Immunol 2017 ;27(1):1-18
    Unidade de Alergia e Imunologia do Instituto da Criança, HC Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
    Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-, cell-mediated food allergy of unknown prevalence and pathophysiology. Onset is typically during the first year of life; seafood-induced FPIES may start in adulthood. Acute FPIES manifests within 1-4 hours after ingestion with repetitive emesis, pallor, and lethargy progressing to dehydration and hypovolemic shock in 15% of cases. Read More

    Aspirin Desensitization in Patients With Coronary Artery Disease: Results of the Multicenter ADAPTED Registry (Aspirin Desensitization in Patients With Coronary Artery Disease).
    Circ Cardiovasc Interv 2017 Feb;10(2)
    From the Dipartimento Cardiovascolare, ASST Papa Giovanni XXIII, Bergamo, Italy (R.R., A.I., G.M., M.S.); Division of Cardiology, A.O.U San Luigi Gonzaga, Orbassano, Torino, Italy (R.P., M.B.); IRCCS Fondazione Policlinico S. Matteo, Pavia, Italy (S.L.); Divisione di Cardiologia, Ospedale Carlo Poma, Mantova, Italy (C.L.); Cardiologia 1 Emodinamica, Dipartimento Cardiovascolare, ASST Niguarda Grande Ospedale Metropolitano, Milano, Italy (I.B., P.C.); U.O. Emodinamica, Ospedale Sandro Pertini, Roma, Italy (S.R.); Università degli Studi di Pavia, Italy (C.D.); Unità operativa di Cardiologia, Humanitas Mater Domini, Castellanza (Varese), Italy (A.A.); Cardio-Thoracic-Vascular Department, Ferrarotto Hospital, University of Catania, Italy (D.C.); and Division of Cardiology, University of Florida College of Medicine, Jacksonville (D.J.A.).
    Background: There are limited data on aspirin (ASA) desensitization for patients with coronary artery disease. The aim of the present study was to assess the safety and efficacy of a standard rapid desensitization protocol in patients with ASA sensitivity undergoing coronary angiography.

    Methods And Results: This is a prospective, multicenter, observational study including 7 Italian centers including patients with a history of ASA sensitivity undergoing coronary angiography with intent to undergo percutaneous coronary intervention. Read More

    ACE inhibitors may interfere with omalizumab in chronic spontaneous urticaria.
    J Eur Acad Dermatol Venereol 2017 Feb 9. Epub 2017 Feb 9.
    Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano (MI), Italy.
    The extrinsic pathway of coagulation cascade is activated in chronic spontaneous urticaria (CSU), and such activation parallels disease severity (1). D-dimer levels are elevated in cases resistant to antihistamines (2) and/or cyclosporine (3). Omalizumab is highly effective in most patients with severe, antihistamine-resistant CSU. Read More

    Thyrotropin receptor gene expression in the association between chronic spontaneous urticaria and Hashimoto's thyroiditis.
    Int J Dermatol 2017 Feb 8. Epub 2017 Feb 8.
    Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University - Unesp, Botucatu, Sao Paulo, Brazil.
    Background: Chronic spontaneous urticaria (CSU) may be associated with autoimmune thyroid diseases, and the Autologous Serum Skin Test (ASST) is an autoreactivity marker. The thyrotropin (TSH) and TSH receptor (TSHR) could play a role in the pathogenesis of CSU. The aim of this study was to evaluate ASST positivity and TSHR gene expression in healthy skin and ASST wheals in euthyroid women with CSU, with (14 patients) and without (15 patients) Hashimoto's thyroiditis (HT). Read More

    Allergic diseases in the elderly: biological characteristics and main immunological and non-immunological mechanisms.
    Clin Mol Allergy 2017 3;15. Epub 2017 Feb 3.
    0000 0001 2151 3065grid.5606.5Allergy and Respiratory Diseases, IRCCS San Martino-IST-University of Genoa, Genoa, Italy.
    Life expectancy and the number of elderly people are progressively increasing around the world. Together with other pathologies, allergic diseases also show an increasing incidence in geriatric age. This is partly due to the growing emphasis on a more accurate and careful diagnosis of the molecular mechanisms that do not allow to ignore the real pathogenesis of many symptoms until now unknown, and partly to the fact that the allergic people from 20 years ago represent the elderly population now. Read More

    Pathogenic mechanisms of IgE-mediated inflammation in self-destructive autoimmune responses.
    Autoimmunity 2017 Feb;50(1):25-36
    a Department of Respiratory , Inflammation & Autoimmunity, MedImmune LLC , Gaithersburg , MD , USA.
    Autoantibodies of the IgG subclass are pathogenic in a number of autoimmune disorders such as systemic lupus erythomatosus. The presence of circulating IgE autoantibodies in autoimmune patients has also been known for almost 40 years. Despite their role in allergies, IgE autoantibodies are not associated with a higher rate of atopy in these patients. Read More

    H1-antihistamine-refractory chronic spontaneous urticaria: It's worse than we thought - first results of the multicenter real-life AWARE study.
    Clin Exp Allergy 2017 Feb 4. Epub 2017 Feb 4.
    Novartis Pharma GmbH, Nürnberg, Germany.
    Background: Most data on chronic spontaneous urticaria (CSU) originate from highly selected patient populations treated at specialized centers. Little is known about CSU patient characteristics and the burden of CSU in routine clinical practice. AWARE (A World-wide Antihistamine-Refractory chronic urticaria patient Evaluation) is an ongoing global study designed to assess chronic urticaria in the real-life setting. Read More

    Single nucleotide polymorphisms of IL-2, but not IL-12 and IFN-γ, are associated with increased susceptibility to chronic spontaneous urticaria.
    Allergol Immunopathol (Madr) 2017 Feb 1. Epub 2017 Feb 1.
    Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Boston, MA, USA. Electronic address:
    Background: A clear picture of interaction of Th1/Th2 cytokines in pathogenesis of chronic spontaneous urticaria (CSU), remains elusive. Impaired IFN-γ production and decreased levels of IL-2 have been reported. The aim of this study was to evaluate the association of Th1 cytokines; IL-2, IL-12 and IFN-γ polymorphisms with CSU. Read More

    Chronic Urticaria and Atopic Disorders: a Cross-sectional Study of 11,271 Patients.
    Br J Dermatol 2017 Jan 27. Epub 2017 Jan 27.
    Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
    Chronic urticaria (CU) and atopic disorders such as atopic dermatitis (AD), allergic rhinoconjunctivitis (AR), and asthma are related to aberrant immune function. The relationship between atopic disorders and CU is controversial, mostly since epidemiological data are lacking. The aim of our study was to investigate the association between CU and asthma, AD, and AR using a database of Clalit Health Services (CHS) - the largest healthcare provider organization in Israel. Read More

    Omalizumab for treating chronic spontaneous urticaria: an expert review on efficacy and safety.
    Expert Opin Biol Ther 2017 Mar 9;17(3):375-385. Epub 2017 Feb 9.
    a Dermatology Department, Hospital del Mar IMIM , Universitat Autònoma and Universitat Pompeu Fabra , Barcelona , Spain.
    Introduction: Chronic spontaneous urticaria (CSU) is characterized by the recurrence of itchy hives and/or angioedema for greater than six weeks, with no known external trigger. Omalizumab, a humanized, recombinant, monoclonal anti-IgE antibody, is the only approved add-on therapy for H1-antihistamine refractory CSU patients. Areas covered: The objective of this article is to discuss the mechanism of action, pharmacokinetics and pharmacodynamics of omalizumab for the treatment of CSU. Read More

    High-dose anti-histamine use and risk factors in children with urticaria.
    Turk Pediatri Ars 2016 Dec 1;51(4):198-203. Epub 2016 Dec 1.
    Division of Pediatric Allergy and Clinical Immunology, Adnan Menderes University School of Medicine, Aydın, Turkey.
    Aim: The drugs of choice in the treatment of urticaria in children are H1-antihistamines. The aim of the study was to evaluate children with urticaria and define risk factors for requirement of high-dose H1-antihistamines in children with urticaria.

    Material And Methods: The medical data of children who were diagnosed as having urticaria admitted to our outpatient clinic between January 2014 and January 2016 were searched. Read More

    Correlation between the histopathology of chronic urticaria and its clinical picture.
    An Bras Dermatol 2016 Nov-Dec;91(6):760-763
    Faculdade de Medicina do ABC (FMABC) - Santo André (SP), Brazil.
    Background:: Chronic urticaria is characterized by transient, pruritic lesions of varying sizes, with central pallor and well-defined edges, with disease duration longer than six weeks. Its cellular infiltrate consists of neutrophils, lymphocytes and eosinophils. There is a subgroup of patients with eosinophilic or neutrophilic urticaria, resistant to the treatment with antihistamines, but that respond to a combination of antihistamine with other drugs. Read More

    Impact of chronic urticaria on the quality of life of patients followed up at a university hospital.
    An Bras Dermatol 2016 Nov-Dec;91(6):754-759
    University of Genoa - Genoa, Italy.
    Background:: Chronic urticaria is a debilitating disease that considerably affects health-related quality of life, and the Chronic Urticaria Quality of Life Questionnaire is the only questionnaire specifically designed for its evaluation.

    Objective:: To evaluate the quality of life of patients with chronic urticaria, using the Brazilian Portuguese version of the Chronic Urticaria Quality of Life Questionnaire.

    Methods:: The Chronic Urticaria Quality of Life Questionnaire was self-administered in 112 chronic urticaria patients and disease activity was assessed through the Urticaria Activity Score. Read More

    IgE-Related Chronic Diseases and Anti-IgE-Based Treatments.
    J Immunol Res 2016 21;2016:8163803. Epub 2016 Dec 21.
    Biochemistry Unit, Biomedicine Department, Faculty of Medicine, University of Barcelona, Casanova 143, 08036 Barcelona, Spain.
    IgE is an immunoglobulin that plays a central role in acute allergic reactions and chronic inflammatory allergic diseases. The development of a drug able to neutralize this antibody represents a breakthrough in the treatment of inflammatory pathologies with a probable allergic basis. This review focuses on IgE-related chronic diseases, such as allergic asthma and chronic urticaria (CU), and on the role of the anti-IgE monoclonal antibody, omalizumab, in their treatment. Read More

    Disorders characterized by predominant or exclusive dermal inflammation.
    Semin Diagn Pathol 2016 Dec 14. Epub 2016 Dec 14.
    Section of Dermatopathology, Division of Surgical Pathology & Cytopathology, University of Virginia Medical Center, Room 3020 University of Virginia Hospital, 1215 Lee Street, Charlottesville, VA 22908-0214, USA. Electronic address:
    Some cutaneous inflammatory disorders are typified by a predominant or exclusive localization in the dermis. They can be further subdivided by the principal cell types into lymphocytic, neutrophilic, and eosinophilic infiltrates, and mixtures of them are also seen in a proportion of cases. This review considers such conditions. Read More

    Cutaneous exposure to vesicant phosgene oxime: Acute effects on the skin and systemic toxicity.
    Toxicol Appl Pharmacol 2017 Feb 11;317:25-32. Epub 2017 Jan 11.
    Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
    Phosgene Oxime (CX), an urticant or nettle agent categorized as a vesicant, is a potential chemical warfare and terrorist weapon. Its exposure can result in widespread and devastating effects including high mortality due to its fast penetration and ability to cause immediate severe cutaneous injury. It is one of the least studied chemical warfare agents with no effective therapy available. Read More

    Current and future therapies for the treatment of histamine-induced angioedema.
    Expert Opin Pharmacother 2017 Feb 25;18(3):253-262. Epub 2017 Jan 25.
    a Department of Internal Medicine, Division of Immunology, Rheumatology, and Allergy , University of Cincinnati College of Medicine , Cincinnati , Ohio , USA.
    Introduction: Angioedema, a sudden, self-limited swelling of localized areas of any part of the body that may or may not be associated with urticaria, is thought to be the result of a mast-cell mediated process versus a bradykinin etiology. Understanding the mechanism is key in determining the proper treatment. Areas Covered: Clinical presentation of varying angioedema types may be similar; however, the appropriate treatment algorithm is dependent upon clinicians' knowledge of the underlying pathophysiology and classification of angioedema. Read More

    Looking forward to new targeted treatments for chronic spontaneous urticaria.
    Clin Transl Allergy 2017 10;7. Epub 2017 Jan 10.
    St John's Institute of Dermatology, Guy's Hospital, London, UK.
    The introduction of omalizumab to the management of chronic spontaneous urticaria (CSU) has markedly improved the therapeutic possibilities for both, patients and physicians dealing with this disabling disease. But there is still a hard core of patients who do not tolerate or benefit from existing therapies and who require effective treatment. Novel approaches include the use of currently available drugs off-licence, investigational drugs currently undergoing clinical trials and exploring the potential for therapies directed at pathophysiological targets in CSU. Read More

    Prevalence of dermatologic diseases among patients with selective immunoglobulin A deficiency.
    Allergy Asthma Proc 2017 Jan;38(1):70-77
    Background: There are no published large-scale epidemiologic studies regarding the prevalence of skin diseases in patients with selective immunoglobulin A (IgA) deficiency (sIgAD). The purpose of this study was to investigate the prevalence of dermatological diseases in patients with sIgAD.

    Methods: This retrospective matched case-control study was based on data from the Leumit Healthcare Services data base (approximately 725,000 residents of Israel), which was searched for all subjects aged ≥12 years who had undergone serum total IgA measurements during 2004-14 for any reason. Read More

    Involvement of microRNAs in skin disorders: A literature review.
    Allergy Asthma Proc 2017 Jan;38(1):9-15
    Background: miRNAs are a class of noncoding RNA molecules that modulate gene expression after transcription. It is known that miRNAs are involved in various cellular processes of both normal and diseased skin. Recently, differential expressions of miRNAs have been reported and associated with several immunologic and inflammatory disorders, which indicate a common role in fundamental biologic processes. Read More

    The role and choice criteria of antihistamines in allergy management - expert opinion.
    Postepy Dermatol Alergol 2016 Dec 2;33(6):397-410. Epub 2016 Dec 2.
    Department of Lung Diseases and Rheumatology, 2 Faculty of Medicine, Medical University of Lublin, Lublin, Poland.
    Allergic diseases are the most common chronic conditions lasting throughout the patient's life. They not only cause significant deterioration in the quality of life of patients but also lead to significant absenteeism and reduced productivity, resulting in very high costs for society. Effective and safe treatment of allergic diseases is therefore one of the main challenges for public health and should be carried out by all the specialists in family medicine, internists and paediatricians in collaboration with allergists, otorhinolaryngologists and dermatologists. Read More

    Management of chronic spontaneous urticaria in routine clinical practice: A Delphi-method questionnaire among specialists to test agreement with current European guidelines statements.
    Allergol Immunopathol (Madr) 2016 Oct 28. Epub 2016 Oct 28.
    Pneumology and Allergy Service, Hospital Clinic (ICT), University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) [August Pi i Sunyer Biomedical Research Institute], Barcelona, Spain.
    Background: Chronic spontaneous urticaria (CSU) is a frequent clinical entity that often presents a diagnostic and therapeutic challenge.

    Objective: To explore the degree of agreement that exists among the experts caring for patients with CSU diagnosis, evaluation, and management.

    Methods: An online survey was conducted to explore the opinions of experts in CSU, address controversial issues, and provide recommendations regarding its definition, natural history, diagnosis, and treatment. Read More

    Human basophils are a soucre of - and are differentially activated by - IL-31.
    Clin Exp Allergy 2016 Dec 21. Epub 2016 Dec 21.
    Medway School of Pharmacy, University of Kent, Chatham Maritime, UK.
    Background: Basophils are important effector cells involved in the pathogenesis of inflammatory skin diseases including chronic urticaria which is associated by increased IL-31 serum levels. So far the effects of IL-31 on human basophils are unknown.

    Objective: To analyse the functional role of IL-31 in basophil biology. Read More

    [Partial response of solar urticaria to omalizumab therapy].
    Hautarzt 2016 Dec 19. Epub 2016 Dec 19.
    Klinik für Hautkrankheiten und Allergologie, HELIOS Vogtland-Klinikum Plauen GmbH, 100153, 08505, Plauen, Deutschland.
    The treatment of solar urticaria is regarded as difficult. In some cases good responses to the anti-IgE antibody omalizumab (Xolair®), approved for treatment of chronic spontaneous urticaria, have been reported. We report on a 50-year-old Caucasian woman who for the last 5 years has developed localized itching and stinging erythemas following exposure to sunlight accompanied sometimes by anaphylactic reactions. Read More

    Papular urticaria: A review of causal agents in Colombia.
    Biomedica 2016 Dec 1;36(4):632-645. Epub 2016 Dec 1.
    Instituto de Investigaciones Inmunológicas, Universidad de Cartagena, Cartagena, Colombia.
    Papular urticaria is a chronic allergic reaction induced by insect bites, which is common in the tropics. The objective of this review was to deepen on epidemiological and immunological aspects of this disease, focused on data published in Latin American countries.We conducted a non-systematic review of the literature through electronic search on the epidemiology of papular urticaria, the entomological characteristics of the causative agents and associated immunological mechanisms. Read More

    Direct Medical Costs of Chronic Urticaria in a Private Health Organization of Buenos Aires, Argentina.
    Value Health Reg Issues 2016 Dec 21;11:57-59. Epub 2016 Oct 21.
    Allergy division, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
    Background: Scarce studies address the issue of resource consumption and direct health care costs of patients diagnosed with adult-onset chronic urticaria (CU).

    Objectives: To estimate medical resource consumption and direct health care costs of affected patients in a private health maintenance organization in Buenos Aires, Argentina.

    Methods: Patients diagnosed with adult-onset CU (International Classification of Diseases, Ninth Revision, Clinical Modification code 708. Read More

    Basophil Activation Test identifies the patients with Chronic Spontaneous Urticaria suffering the most active disease.
    Immun Inflamm Dis 2016 Dec 4;4(4):441-445. Epub 2016 Oct 4.
    Department of Dermatology Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Universitat Autònoma Barcelona Spain.
    Introduction: The basophil activation test showing CD63 up regulation could be a specific and sensitive in vitro complementary text to the in vivo autologous serum skin test for the activity assessment of the patients suffering autoimmune chronic spontaneous urticaria. The aim of this study is to define the basophil activation test as a useful tool in clinical practice in order to identify those patients with more active disease.

    Methods: We screened 139 patients (96 women) diagnosed of chronic spontaneous urticaria using simultaneously autologous serum skin test and basophil activation test and their relationship with disease activity. Read More

    Re-exposure to low osmolar iodinated contrast media in patients with prior moderate-to-severe hypersensitivity reactions: A multicentre retrospective cohort study.
    Eur Radiol 2016 Dec 14. Epub 2016 Dec 14.
    Division of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
    Objectives: To evaluate the outcomes of re-exposure to low-osmolar iodinated contrast medium (LOCM) in patients with a history of moderate-to-severe hypersensitivity reaction (HSR).

    Methods: We retrospectively evaluated a cohort comprising all subjects satisfying the following conditions at 11 centres: (1) experienced a moderate-to-severe HSR to LOCM by December 2014, and (2) underwent contrast-enhanced computed tomography after the initial HSR between January 2014 and December 2014.

    Results: A total of 150 patients with 328 instances of re-exposure were included; the recurrence rate of HSR was 19. Read More

    Immunogenicity of a peptide-based anti-IgE conjugate vaccine in non-human primates.
    Immun Inflamm Dis 2016 Jun 1;4(2):135-147. Epub 2016 Apr 1.
    Pfizer Vaccine Immunotherapeutics Ottawa Laboratories Ottawa Ontario Canada.
    The anti-human immunoglobulin E (IgE) monoclonal antibody, omalizumab (Xolair®, Genentech, South San Fransisco, CA), is effective in the treatment of poorly controlled moderate to severe allergic asthma and chronic idiopathic urticaria. It acts by specifically binding to the constant domain (Cϵ3) of free human IgE in the blood and interstitial fluid. Although efficacious, use of omalizumab is limited due to restrictions on patient weight and pre-existing IgE levels, and frequent dosing (q2-4 weeks). Read More

    Omalizumab for chronic urticaria in Latin America.
    World Allergy Organ J 2016 23;9(1):36. Epub 2016 Nov 23.
    Universidad de Especialidades Espíritu Santo, School of Medicine, Samborondón, Guayas 09150 Ecuador ; Respiralab Research Group, Guayaquil, Ecuador.
    Background: Chronic urticaria (CU) is defined as the spontaneous appearance of wheals, with or without angioedema, persisting for ≥6 weeks. Chronic Spontaneous Urticaria (CSU) is a type of CU which affects 0.5-1 % of the global population, but it represents a high burden to patients. Read More

    Acrally distributed dermatoses: Vascular dermatoses (purpura and vasculitis).
    Clin Dermatol 2017 Jan - Feb;35(1):68-80. Epub 2016 Sep 10.
    Department of Dermatology and Venereology, Tokuda Hospital Sofia, Sofia, Bulgaria.
    Purpuric lesions appear in acral distribution in a variety of conditions and often provide clues to the clinical diagnosis. Purpuric means "hemorrhagic"-that is, the lesions do not blanch from pressure. This review focuses on dermatoses that produce hemorrhagic lesions in acral distribution from the large groups of the vasculitic diseases and their mimics. Read More

    Corticosteroid-related toxicity in patients with chronic idiopathic urticariachronic spontaneous urticaria.
    Allergy Asthma Proc 2016 Nov;37(6):458-465
    Division of Allergy and Immunology, Morsani College of Medicine, University of South Florida and the James A. Haley Veterans Hospital, Tampa, Florida, USA.
    Background: Treatments for patients with chronic idiopathic urticaria (CIU)chronic spontaneous urticaria (CSU) who were unresponsive to antihistamines include oral corticosteroids (OCS). Risks of OCS-related side effects in these patients have not been described quantitatively.

    Objective: To investigate the relationship between OCS use and the risk of developing side effects possibly attributable to OCS and associated health care costs in privately insured patients with CIU/CSU. Read More

    Clinical and etiologic evaluation of the children with chronic urticaria.
    Allergy Asthma Proc 2016 Nov;37(6):450-457
    Pediatric Allergy and Immunology, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey.
    Background: Chronic urticaria (CU) is a skin disorder defined as daily or almost daily exhibition of pruritic and transient wheals that last for 6 weeks. CU is divided into two subtypes: chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU).

    Objectives: To evaluate the clinical features, possible causes, associated findings, and laboratory results of different subtypes of CU in children according to a new classification. Read More

    Investigation of thiol-disulphide balance in patients with acute urticaria and chronic spontaneous urticaria.
    Cutan Ocul Toxicol 2017 Jan 18:1-6. Epub 2017 Jan 18.
    c Department of Biochemistry , Ministry of Health Atatürk Training and Research Hospital , Ankara , Turkey.
    Background: Thiol-disulphide balance plays a major role in health and diseases. This balance may be disrupted by various diseases. We aimed to determine status of the effect of thiol-disulphide balance in urticaria. Read More

    Potential blood biomarkers in chronic spontaneous urticaria.
    Clin Exp Allergy 2017 Jan;47(1):19-36
    Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany.
    Chronic spontaneous urticaria (CSU) is a mast cell-driven disease that is defined as the recurrence of weals, angioedema or both for > 6 weeks due to known or unknown causes. As of yet, disease diagnosis is purely clinical. Objective tools are needed to monitor the activity of CSU and the efficacy of treatment. Read More

    The Effect of Autologous Serum Therapy on Disease Severity in Patients with Chronic Urticaria.
    Iran J Allergy Asthma Immunol 2016 Aug;15(4):328-333
    Allergy Research Center, Division of Immunology and Allergy, Nemazee Teaching Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
    Limited evidence has been obtained concerning the beneficial effects of autologous serum therapy in treatment of skin disorders particularly chronic urticaria. In the present study, we have assessed the effect of this treatment method in patients with chronic urticaria (CU). This randomized single-blind controlled trial was performed on fifty consecutive patients with chronic urticaria. Read More

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