Search our Database of Scientific Publications and Authors

I’m looking for a

    4331 results match your criteria Urticaria Chronic

    1 OF 87

    Chronic spontaneous urticaria and the extrinsic coagulation system.
    Allergol Int 2017 Oct 6. Epub 2017 Oct 6.
    Department of Dermatology, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan. Electronic address:
    Chronic spontaneous urticaria (CSU) is a common skin disorder characterized by daily or almost daily recurring skin edema and flare with itch. Recently, the activation of the blood coagulation cascade has been suggested to be involved in CSU, but the trigger of the coagulation cascade remains unclear. In this article, we review recent understanding of the relationship between the pathogenesis of CSU and extrinsic coagulation reactions. Read More

    Epidemiology and comorbidities of patients with chronic urticaria in Korea: A nationwide population-based study.
    J Dermatol 2017 Oct 6. Epub 2017 Oct 6.
    Department of Dermatology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
    Few population-based studies have focused on the epidemiology and comorbidities of chronic urticaria (CU) or chronic spontaneous urticaria (CSU). The objective of this study was to obtain information on the epidemiology and comorbidities associated with CU and CSU in Korea. We conducted a cross-sectional analysis using a national health insurance database. Read More

    Anti-IgE Treatment for Disorders Other Than Asthma.
    Front Med (Lausanne) 2017 21;4:152. Epub 2017 Sep 21.
    Division of Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Washington University in St. Louis School of Medicine, St. Louis, MO, United States.
    Immunoglobulin E (IgE) plays a key role in the pathogenesis of many allergic diseases. Thus, IgE-mediated immunologic pathways are an attractive target for intervention in allergic diseases. Omalizumab is a recombinant humanized monoclonal antibody that binds IgE and has been used treat allergic asthma for over a decade. Read More

    Subcutaneous Autologous Serum Therapy in Chronic Spontaneous Urticaria.
    Indian J Dermatol 2017 Sep-Oct;62(5):505-507
    Department of Dermatology, D. Y. Patil Hospital, Navi Mumbai, Maharashtra, India.
    Background: There is a felt need for trying newer therapeutic modalities in patients with chronic spontaneous urticaria, especially in the subset of patients classified as non-responders to antihistamines. Autologous serum therapy is an upcoming modality of treatment, and we decided to study its efficacy by subcutaneous route.

    Aims: To evaluate the effectiveness of subcutaneous autologous serum therapy (AST) in CSU. Read More

    Evaluating Comorbidities, Natural History, and Predictors of Early Resolution in a Cohort of Children With Chronic Urticaria.
    JAMA Dermatol 2017 Sep 27. Epub 2017 Sep 27.
    Division of Allergy and Clinical Immunology, Department of Pediatrics, McGill University Health Centre, Montreal, Quebec, Canada.
    Importance: Chronic urticaria (CU) affects 0.1% to 0.3% of children. Read More

    Critical appraisal of the unmet needs in the treatment of chronic spontaneous urticaria with omalizumab: an Italian perspective.
    Curr Opin Allergy Clin Immunol 2017 Sep 28. Epub 2017 Sep 28.
    aAmbulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano bPersonalized Medicine Asthma and Allergy Clinic, Humanitas Research Hospital, Humanitas University, Rozzano, Milan cDepartment of Dermato-Allergology, San Gallicano Dermatological Institute, IRCCS, Rome dDepartment of Medical Sciences, Dermatologic Clinic, University of Turin, Turin eSection of Dermatology and Venereology, Department of Medicine, University of Verona, Verona fUnità Operativa di Dermatologia, Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, IRCCS Fondazione Ca' Granda Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan gDepartment of Allergy and Clinical Immunology, University of Bari, Bari hDermatology Unit, Department of Surgical, Medical, Dental and Morphological Sciences with Interest in Transplant, Oncological and Regenerative Medicine, University of Modena and Reggio Emilia, Modena iUnit of Dermatology, Department of Biomedical, Surgical, and Dental Sciences, IRCCS Galeazzi Hospital, University of Milan, Milan jSOD Immunoallergologia Azienda Ospedaliero Universitaria Careggi, Firenze, Italy.
    Purpose Of Review: The humanized anti-IgE antibody omalizumab has been available for patients with chronic spontaneous urticaria (CSU) in Italy since 2015. This review summarizes the unresolved issues and unmet therapeutic needs associated with omalizumab and discusses practical recommendations for its use in the management of CSU.

    Recent Findings: Although modern second-generation H1-antihistamines are the standard of care for patients with CSU, adjunctive treatments (including omalizumab) may be required for effective control of symptoms in many patients. Read More

    [Giardia duodenalis and its involvement in skin diseases].
    Ann Dermatol Venereol 2017 Sep 28. Epub 2017 Sep 28.
    Fondation Cheikh Khalifa Mohammed VI, Casablanca, Maroc; Faculté de médecine et de pharmacie, université Hassan II, Casablanca, Maroc.
    Backgound: Over the last thirty years, the scientific community has become increasingly interested in the intestinal flora, whether commensal or pathogenic, and its impact on other organs. In dermatology, the correlation between intestinal microbial agents and cutaneous lesions is well established. Giardia duodenalis, an intestinal parasite, has been particularly widely studied. Read More

    Aspirin and Nonsteroidal Antiinflammatory Drugs Hypersensitivity and Management.
    Immunol Allergy Clin North Am 2017 Nov 1;37(4):727-749. Epub 2017 Sep 1.
    Division of Allergy, Asthma and Immunology, Scripps Clinic, 3811 Valley Centre Drive, S99, San Diego, CA 92130, USA.
    Aspirin and nonsteroidal antiinflammatory drugs (NSAIDs) are widely used in the United States and throughout the world for a variety of indications. Several unique hypersensitivity syndromes exist to this class of medications, making them one of the common reasons for consultation to the allergist. The lack of any laboratory-based diagnostic studies to assist in identifying the culprits in these reactions make evaluation of aspirin and NSAID hypersensitivity challenging. Read More

    Emerging Roles for MAS-Related G Protein-Coupled Receptor-X2 in Host Defense Peptide, Opioid, and Neuropeptide-Mediated Inflammatory Reactions.
    Adv Immunol 2017 24;136:123-162. Epub 2017 Jul 24.
    University of Pennsylvania School of Dental Medicine, Philadelphia, PA, United States. Electronic address:
    Mast cells (MCs) are tissue-resident immune cells that contribute to host defense but are best known for their roles in allergic and inflammatory diseases. In humans, MCs are divided into two subtypes based on the protease content of their secretory granules. Thus, human lung MCs contain only tryptase and are known as MCT, whereas skin MCs contain both tryptase and chymase and are known as MCTC. Read More

    Childhood Chronic Prurigo: interest of Patch tests and delayed reading Skin prick tests to environmental allergens.
    J Allergy Clin Immunol 2017 Sep 21. Epub 2017 Sep 21.
    Pediatric Dermatology Unit, Hôpital Pellegrin-enfants, Bordeaux University Hospital, Bordeaux, France.
    Childhood chronic prurigo is rarely studied in particular for allergic components. We propose a clinical classification according to seasonality of prurigo in three groups to help identifying causal agents and guide allergy testing with delayed readings tests. Read More

    Inducible T-cell costimulator (ICOS) and CD28 polymorphisms possibly play a role in the pathogenesis of chronic autoreactive urticaria.
    Clin Exp Dermatol 2017 Sep 20. Epub 2017 Sep 20.
    Department of Internal Diseases and Nephrodiabetology, Medical University of Lodz, Lodz, Poland.
    Background: Clinical experience emphasizes the coexistence of chronic spontaneous urticaria (CSU) and autoimmune disturbances. In chromosome 2q33-34, there is a cluster of homologous genes that are considered promising candidate genes for susceptibility to autoimmune diseases.

    Aim: To examine the possible role of polymorphisms in the genes for CD28 and inducible T-cell costimulator (ICOS) in the background of CSU. Read More

    Cyclosporine for Chronic Spontaneous Urticaria: A Meta-Analysis and Systematic Review.
    J Allergy Clin Immunol Pract 2017 Sep 12. Epub 2017 Sep 12.
    Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
    Background: Despite widely recommended usage of cyclosporine A (CsA) in chronic spontaneous urticaria (CSU), there is no meta-analysis concerning its efficacy and safety.

    Objective: To meta-analyze and review the efficacy and safety of CsA in CSU.

    Methods: Efficacy was assessed by the relative change in urticaria activity score at 4 weeks and response rates at 4, 8, and 12 weeks. Read More

    Chronic Spontaneous Urticaria: Pathogenesis and Treatment Considerations.
    Allergy Asthma Immunol Res 2017 Nov;9(6):477-482
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Allergy and Clinical Immunology, Medical University of South Carolina, Charleston, SC, USA.
    The treatment of chronic spontaneous urticaria begins with antihistamines; however, the dose required typically exceeds that recommended for allergic rhinitis. Second-generation, relatively non-sedating H₁-receptor blockers are typically employed up to 4 times a day. First-generation antihistamines, such as hydroxyzine or diphenhydramine (Atarax or Benadryl), were employed similarly in the past. Read More

    Chronic Urticaria and Irritable Bowel Syndrome: a Cross-Sectional Study of 11,271 Patients.
    Br J Dermatol 2017 Sep 14. Epub 2017 Sep 14.
    Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
    The human body interacts with the environment mainly through three major tissues: the lungs, skin, and gastrointestinal (GI) tract. In each one, an intensive nervous network is present, conjugated with abundant mast cells (MC). While MC-mediated disorders in airways and the skin are extensively discussed, MC-mediated disorders of the GI tract remain relatively uncommon. Read More

    Burden of chronic urticaria relative to psoriasis in five European countries.
    J Eur Acad Dermatol Venereol 2017 Sep 12. Epub 2017 Sep 12.
    Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
    Background: Quantification of burden of chronic spontaneous urticaria (CSU) vs. psoriasis (PsO) is limited.

    Objective: To evaluate the burden associated with CSU vs. Read More

    Recurrence of Chronic Urticaria: Incidence and Associated Factors.
    J Allergy Clin Immunol Pract 2017 Sep 6. Epub 2017 Sep 6.
    Department of Internal Medicine, Division of Allergy & Immunology, University of Texas Southwestern Medical Center, Dallas, Tex. Electronic address:
    Background: Chronic urticaria (CU) is urticaria that has been present continuously or intermittently for at least 6 weeks. Although the prevalence and characteristics of CU are well established, little is known about recurrent CU (RCU).

    Objectives: We sought to establish a definition, determine the frequency, and evaluate risk factors for RCU. Read More

    Hydroxychloroquine in the treatment of anti-histamine refractory chronic spontaneous urticaria, randomized single-blinded placebo-controlled trial and an open label comparison study.
    Eur Ann Allergy Clin Immunol 2017 Sep;49(5):220-224
    Division of Allergy and Clinical Immunology, Department of Medicine, Phramongkutklao Hospital, Bangkok, Thailand.
    Summary: Background. The management of anti-histamine refractory chronic spontaneous urticaria (CSU) has poorly defined therapeutic options. Some patients with CSU respond poorly to a fourfold increase in dosage of H1-anti-histamines treatment. Read More

    The link between chronic spontaneous urticaria and metabolic syndrome.
    Eur Ann Allergy Clin Immunol 2017 Sep;49(5):208-212
    Dermatology and Venereology Private Practice, Bari and Barletta, Italy.
    Summary: Metabolic syndrome (MS) is a cluster of risk factors for cardiovascular disease and is considered a chronic low-level systemic inflammatory condition. Recent preliminary findings have shown an increased prevalence of MS among patients with chronic urticaria (CU) as compared to controls, with a particularly higher prevalence detected in patients with uncontrolled CU. Chronic spontaneous urticaria (CSU) appears to share some pathomechanisms with MS, including a pro-inflammatory state, increased oxidative stress, alterations in adipokine profile and activation of the coagulation system. Read More

    [Up-regulated expression of NK1R in eosinophil-enriched blood cells from patients with chronic spontaneous urticaria].
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2017 Aug;33(8):1108-1112
    Allergy and Clinical Immunology Research Centre, First Affiliated Hospital, Jinzhou Medical University, Jinzhou 121001, China. *Corresponding author, E-mail:
    Objective To investigate the expressions of substance P (SP) and neurokinin-1 receptor (NK1R) in eosinophil-enriched blood cells from patients with chronic spontaneous urticaria (CSU). Methods Peripheral venous blood samples were collected from patients with CSU and healthy controls (HCs), and then stimulated with crude extracts of Artemisia pollen, dust mite, and Platanus pollen (all at concentrations of 0.1 and 1. Read More

    Immunological Mechanisms Implicated in the Pathogenesis of Chronic Urticaria and Hashimoto Thyroiditis.
    Iran J Allergy Asthma Immunol 2017 Aug;16(4):358-366
    Anima Medical Center, Bucharest, Romania.
    Autoimmunity represents the attack of the immune system of an organism against its own cells and tissues. Autoimmune diseases may affect one organ (Hashimoto thyroiditis) or can be systemic (chronic urticaria). Many factors are implicated in the pathogenesis of autoimmunity (white cells, cytokines, chemokines). Read More

    The Histopathology of Urticaria Revisited-Clinical Pathological Study.
    Am J Dermatopathol 2017 Oct;39(10):753-759
    *Department of Dermatology, Sheba Medical Center, Tel-Hashomer, Israel; and †Institute of Pathology, Sheba Medical Center, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Background: The classic histopathological findings of urticaria include dermal edema and a sparse perivascular infiltrate of neutrophils, eosinophils, macrophages, and lymphocytes. However, this pattern is inconsistently described.

    Objective: To describe the histological and immunofluorescence characteristics of urticaria and to identify distinctive patterns. Read More

    Management of chronic spontaneous urticaria (CSU): a treat to target approach using a patient reported outcome.
    Allergy Asthma Clin Immunol 2017 24;13:38. Epub 2017 Aug 24.
    Division of Allergy and Clinical Immunology, St. Michael's Hospital, Toronto, ON Canada.
    Background: Treat-to-target therapy approaches are established for chronic diseases such as diabetes, hypertension, and more recently rheumatoid arthritis, resulting in improved patient outcomes. These approaches do not use patient reported outcomes (PRO) as targets of therapy. Chronic spontaneous urticaria (CSU), also called chronic idiopathic urticaria (CIU), is defined as recurrent urticaria of known and unknown cause, lasting more than 6 weeks. Read More

    Chronic urticaria and the metabolic syndrome: a cross-sectional community-based study of 11 261 patients.
    J Eur Acad Dermatol Venereol 2017 Aug 28. Epub 2017 Aug 28.
    Medical University of Graz, Graz, Austria.
    Background: Emerging evidence suggests that chronic urticaria (CU) is associated with chronic, low-grade, inflammatory process.

    Objective: To evaluate the association between CU and metabolic syndrome and its components in a large community-based medical database.

    Methods: A cross-sectional study of CU patients and matched controls was performed. Read More

    Different expression patterns of plasma Th1-, Th2-, Th17- and Th22-related cytokines correlate with serum autoreactivity and allergen sensitivity in chronic spontaneous urticaria.
    J Eur Acad Dermatol Venereol 2017 Aug 28. Epub 2017 Aug 28.
    Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China.
    Background: Clinical features and basophil activation levels correlate with serum autoreactivity and allergen sensitivity in patients with chronic spontaneous urticaria (CSU).

    Objectives: To explore the relationship of the expression patterns of plasma T-helper cell (Th) 1-, Th2-, Th17- and Th22-related cytokines with the serum autoreactivity and the allergen sensitivity in CSU.

    Method: Twenty related cytokines were measured and analysed in 60 patients with CSU, 15 patients with acute urticaria, 10 patients with atopic dermatitis (AD) and 15 healthy persons, respectively. Read More

    Omalizumab efficacy in cases of chronic spontaneous urticaria is not explained by the inhibition of sera activity in effector cells.
    Sci Rep 2017 Aug 21;7(1):8985. Epub 2017 Aug 21.
    Department of Allergy and Clinical Immunology, Clinica Universidad de Navarra, Pamplona, Spain.
    Omalizumab (OmAb) is a humanized anti-IgE antibody approved for the treatment of chronic spontaneous urticaria (CSU). OmAb's mechanism of action is known to include actions on free IgE and on pre-bound IgE. However, OmAb is equally and rapidly effective against autoimmune and non-autoimmune urticaria where IgE involvement is not clear, suggesting the involvement of additional mechanisms of action. Read More

    Impact of Jumihaidokuto (Shi-Wei-Bai-Du-Tang) on treatment of chronic spontaneous urticaria: A randomized controlled study.
    Chin J Integr Med 2017 Aug 17. Epub 2017 Aug 17.
    Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, 575-0871, Japan.
    Objective: To study the effect of Jumihaidokuto (Shi-Wei-Bai-Du-Tang, ) in the management of chronic spontaneous urticaria.

    Methods: A randomized two-arm, parallel group study was conducted to compare the effect of Jumihaidokuto (6 g daily) with a control for 8 weeks. Concomitant therapy (e. Read More

    Comparison and interpretability of the available urticaria activity scores.
    Allergy 2017 Aug 16. Epub 2017 Aug 16.
    Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité - Universitätsmedizin Berlin, Berlin, Germany.
    The urticaria activity score (UAS) is the gold standard for assessing disease activity in patients with chronic spontaneous urticaria (CSU). Two different versions, the UAS7 and UAS7TD , are currently used in clinical trials and routine care. To compare both versions and to obtain data on their interpretability, 130 CSU patients applied both versions and globally rated their disease activity as none, mild, moderate, or severe. Read More

    Chronic Urticaria Patient Perspective (CUPP): The First Validated Tool for Assessing Quality of Life in Clinical Practice.
    J Allergy Clin Immunol Pract 2017 Aug 9. Epub 2017 Aug 9.
    Personalized Medicine Clinic: Asthma & Allergy-Humanitas Clinical and Research Center, Department of Biomedical Science, Humanitas University, Rozzano, Milan, Italy.
    Background: There is a need for validated tools to assess health-related quality of life (HRQoL) in routine clinical practice.

    Objective: The aim of this study was to validate the Chronic Urticaria Patient Perspective (CUPP) for assessment of patients with chronic urticaria (CU) in clinical practice.

    Methods: A provisional CUPP was developed from candidate items identified by following an iterative process in a retrospective analysis of 249 Chronic Urticaria Quality of Life Questionnaire questionnaires. Read More

    Mast cells are critical for the limitation of thrombin-induced skin inflammation.
    Exp Dermatol 2017 Aug 8. Epub 2017 Aug 8.
    Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité-Universitätsmedizin Berlin, 10117, Berlin, Germany.
    Thrombin, a key player in coagulation, is widely held to induce and promote inflammation. As of now, the features, kinetics, and control of thrombin's proinflammatory effects on the skin remain to be characterized in detail. We, therefore, injected thrombin into the ear skin of mice and observed strong, dose-dependent, and transient ear swelling responses as well as mast cell degranulation. Read More

    Skin diseases of the vulva: eczematous diseases and contact urticaria.
    J Obstet Gynaecol 2017 Aug 7:1-6. Epub 2017 Aug 7.
    a Department of Dermatology , Bispebjerg Hospital , Copenhagen , Denmark.
    Skin diseases in the vulvar area include a variety of disorders many of which have a chronic course with significant morbidity. It is important to be aware of the symptoms, signs and diagnostic tools in order to optimise treatment. Herein, the most common eczematous diseases of the vulvar area, i. Read More

    Histopathological and clinical evaluation of chronic spontaneous urticaria patients with neutrophilic and non-neutrophilic cutaneous infiltrate.
    Allergol Int 2017 Jul 25. Epub 2017 Jul 25.
    Department of Dermatology, Hospital das Clínicas of the University of São Paulo Medical School, São Paulo, Brazil. Electronic address:
    Background: Chronic urticaria has an expressive prevalence in general population, especially in adults, and is defined by the presence of intermittent hives for six weeks or longer. Our study aims to characterize the histological patterns of chronic spontaneous urticaria, based on the inflammatory cell infiltrate, and correlate them to laboratory exams.

    Methods: It was performed a retrospective analysis of laboratory, histopathology and direct immunofluorescence data of 93 patients with chronic urticaria. Read More

    CRP, D-dimer, fibrinogen and ESR as predictive markers of response to standard doses of levocetirizine in patients with chronic spontaneous urticaria.
    Eur Ann Allergy Clin Immunol 2017 Jul;49(4):189-192
    Department of Dermatology and Venereology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
    Summary: According to current guidelines, non-sedative H1-antihistamines (nsAH) are the first-line therapy of chronic spontaneous urticaria (CSU). But even up-dosed antihistamines (to four times the standard dose) produce symptom resolution in less than 50% of patients. Biomarkers that can predict the response to nsAH are still unknown. Read More

    Effects of omalizumab treatment on serum cytokine concentrations of atopic patients with chronic spontaneous urticaria: a preliminary report.
    Eur Ann Allergy Clin Immunol 2017 Jul;49(4):171-175
    Division of Internal Medicine, Allergy and Clinical Immunology, Department of Medical and Surgical Sciences, Second University of Naples School of Medicine, Naples, Italy. Phone: +39 081 5665 028 Fax: +39 081 5665 080 E-mail:
    Summary: Omalizumab has recently obtained indication for chronic spontaneous urticaria both in the US and Europe. However, the mechanism of action of this drug has yet to be fully elucidated. Previous studies have shown elevations in cytokine serum levels in patients with chronic spontaneous urticaria, and it is not known whether omalizumab treatment may affect cytokine serum levels in this condition. Read More

    Histamine release positive test associates with disease remission in chronic spontaneous urticaria: a proof-of-concept study.
    Eur Ann Allergy Clin Immunol 2017 Jul;49(4):154-160
    Department of Allergy and Clinical Immunology, IRCCS San Raffaele Scientific Institute, Milan, Italy. Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milan, Italy.
    Summary: Background. Histamine release (HR) test has previously been shown to predict the presence of endogenous histamine-releasing factors in chronic spontaneous urticaria (CSU). Objectives and methods. Read More

    Justification for IgE as a therapeutic target in chronic spontaneous urticaria.
    Eur Ann Allergy Clin Immunol 2017 Jul;49(4):148-153
    Dermatology Service, Centro Médico de Caracas, Caracas, Venezuela.
    Summary: Monoclonal anti-IgE antibodies (omalizumab) are able to induce clinically significant benefits in patients with severe chronic spontaneous urticaria (CS). Those results led clinicians and investigators to reconsider a possible pathogenic role not previously supported for IgE and its receptors in this disease, and to investigate additional approaches for understanding its pathogenesis. IgE antibodies to unknown environmental allergens able to trigger chronic urticaria are not generally regarded as the etiologic factor for the disease. Read More

    Chronic urticaria: a focus on pathogenesis.
    F1000Res 2017 11;6:1095. Epub 2017 Jul 11.
    Medicina Interna, Dipartimento di Fisiopatologia Medico Chirurgica e dei Trapianti, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.
    Chronic urticaria is a spontaneous or inducible group of diseases characterized by the occurrence of wheals (and, in about half of cases, angioedema) for more than 6 weeks. These are rather frequent conditions that may severely affect patients' quality of life and sometimes represent a challenge for doctors as well. The causes of chronic urticaria are still poorly defined, although there is growing evidence that different biologic systems including immunity, inflammation, and coagulation may take part in the pathomechanism eventually leading to mast cell and basophil degranulation and hence to wheal formation. Read More

    Omalizumab treatment in patients with chronic inducible urticaria: A systematic review of published evidence.
    J Allergy Clin Immunol 2017 Jul 24. Epub 2017 Jul 24.
    Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
    Background: Omalizumab, a recombinant anti-IgE antibody, effectively treats chronic spontaneous urticaria. Evidence is lacking in patients with chronic inducible urticarias (CIndUs), which are frequently H1-antihistamine resistant.

    Objective: From the current published literature, we aimed to determine the strength of evidence for omalizumab efficacy and safety in the treatment of CIndUs. Read More

    The Burden of Chronic Urticaria from Brazilian Patients' Perspective.
    Dermatol Ther (Heidelb) 2017 Jul 26. Epub 2017 Jul 26.
    Federal University of São Paulo, São Paulo, Brazil.
    Introduction: Chronic urticaria (CU), a proxy for chronic spontaneous urticaria, has been associated with a negative impact on health-related quality of life (HRQoL) and costs, but there is limited evidence on the burden of CU in Brazil. The objective of this study was to estimate the prevalence of CU and assess the burden of CU on HRQoL and healthcare resource utilization (HRU) among adults in Brazil.

    Methods: This retrospective, cross-sectional study, pooled data from the 2011, 2012, and 2015 National Health and Wellness Survey in Brazil (n = 36,000). Read More

    Urticaria and Angioedema: an Update on Classification and Pathogenesis.
    Clin Rev Allergy Immunol 2017 Jul 26. Epub 2017 Jul 26.
    Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, 3010, Bern, Switzerland.
    Urticaria is a common, mast cell-driven disease presenting with wheals or angioedema or both. In the last years, urticaria has increasingly attracted notice to clinicians and researchers, last but not least inspired by the approval of omalizumab, an anti-IgE antibody, for urticaria treatment. There is wide consensus on the clinical classification based on duration and elicitation. Read More

    Epidemiology and comorbidities of patients with chronic urticaria in Taiwan‏: A nationwide population-based study.
    J Dermatol Sci 2017 Jul 15. Epub 2017 Jul 15.
    School of Health Care Administration, Taipei Medical University, Taipei, Taiwan. Electronic address:
    Background: Comprehensive data regarding the epidemiology of chronic urticaria (CU) in general populations are scant.

    Objectives: To investigate the prevalence, incidence, and comorbidities of CU in general population.

    Methods: The data were sourced from the National Health Insurance Research Database (NHIRD) for 2009-2012. Read More

    The expanding field of biologics in the management of chronic urticaria.
    J Allergy Clin Immunol Pract 2017 Jul 19. Epub 2017 Jul 19.
    University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address:
    Chronic urticaria (CU) is the occurrence of urticaria with or without angioedema for at least 6 weeks. Management has traditionally involved antihistamines as first-line therapy with various alternative therapies for refractory cases. Largely based on the success of biologics for various diseases, this class of drugs has come to the forefront of medical research. Read More

    [Chronic urticaria - new views on diagnosis and treatment of disease].
    Cas Lek Cesk 2017 ;156(3):123-126
    Interest in chronic urticaria has grown in recent years, largely owing to the advent of new modes treatment especially in the form of the biologic preparation omalizumab. New scientific and clinical findings have not only facilitated a more comprehensive view of the disease but have streamlined the classification and diagnostic approach as well. Diagnostics are no longer burdened by cumbersome and lengthy investigative procedures into the etiology of urticaria, but are much more rapid and targeted bringing about more timely relief of the patient's symptoms. Read More

    Clinical Outcome of Autologous Serum Therapy in Chronic Idiopathic Urticaria.
    J Nepal Health Res Counc 2017 Jan;15(35):71-74
    Department of Dermatology, Dhulikhel Hospital, Kavre, Nepal.
    Background: Quality of life in chronic idiopathic urticaria is hampered as efficacy of H1-antihistamines is limited. Autologous serum containing tolerance-generating anti-idiotype antibodies is a novel and cost-effective therapy. This study was conducted to evaluate the efficacy of autologous serum therapy (AST) among chronic urticaria patients with autologous skin prick test positive and negative status. Read More

    1 OF 87