4,792 results match your criteria Urticaria Chronic


Rostrum: Itching as a systemic disease.

J Allergy Clin Immunol 2019 Apr 17. Epub 2019 Apr 17.

Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery and Miami Itch Center Miller School of Medicine University of Miami, Miami, FL. Electronic address:

Pruritus is a sensation that emanates from the skin and is transferred via peripheral nerve fibers to the central nervous system. It is easily understood that primary skin disorders such as atopic eczema, skin dryness, psoriasis, and urticaria can elicit pruritus. However certain systemic diseases can cause chronic pruritus that have significant impact on patients' quality of life. Read More

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http://dx.doi.org/10.1016/j.jaci.2019.04.005DOI Listing

Autoimmune Theories of Chronic Spontaneous Urticaria.

Front Immunol 2019 29;10:627. Epub 2019 Mar 29.

Department of Immunology, Duke University Medical Center, Durham, NC, United States.

Urticaria (hives) is a highly prevalent skin disorder that can occur with or without associated angioedema. Chronic spontaneous urticaria (CSU) is a condition which persists for more than 6 weeks in duration and occurs in the absence of an identifiable provoking factor. CSU results from pathogenic activation of mast cells and basophils, which gives rise to the release of proinflammatory mediators that support the generation of urticaria. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450064PMC
March 2019
2 Reads

Serum levels of brain-derived neurotrophic factor in patients with acne vulgaris.

J Cosmet Dermatol 2019 Apr 13. Epub 2019 Apr 13.

Department of Dermatology and Andrology, Faculty of Medicine, Benha University, Benha, Egypt.

Background: Many dermatological diseases have a great impact on the psychological state of patients, like urticaria, psoriasis, atopic dermatitis, and acne vulgaris. Finding a "gold standard" biomarker for chronic stress in acne patients is challenging because of the complex etiology of the chronic stress and its variable manifestations.

Aims: The aim of this study was to evaluate the correlation between serum levels of BDNF and the presence and severity of acne vulgaris and to assess the relationship of this biomarker to both the degree of psychological stress and the quality of patients' lives (QoL). Read More

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http://dx.doi.org/10.1111/jocd.12940DOI Listing
April 2019
5 Reads

Ebastine in the treatment of allergic rhinitis and urticaria: 30 years of clinical studies and real-world experience.

Authors:
J Sastre

J Investig Allergol Clin Immunol 2019 Apr 12. Epub 2019 Apr 12.

Department of Allergy, Fundación Jimenez Diaz, Madrid. CIBERES, Instituto Carlos III. Department of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.

Histamine, acting predominantly via the H1-receptor, is an important mediator of the symptoms of allergy, and H1-antihistamines, which stabilise the receptor in its inactive form, are the treatment of choice for some chronic allergic conditions. Ebastine is a well-established oral second-generation H1-antihistamine. It is administered once daily at a dose of 10-20 mg and is available as a standard tablet and also as a fast-dissolving tablet that disintegrates in the mouth. Read More

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http://dx.doi.org/10.18176/jiaci.0401DOI Listing
April 2019
1 Read

Skin and Systemic Inflammation in Schnitzler's Syndrome Are Associated With Neutrophil Extracellular Trap Formation.

Front Immunol 2019 22;10:546. Epub 2019 Mar 22.

Department of Dermatology and Allergy, Allergie-Centrum-Charité, Berlin Institute of Health, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

Schnitzler's syndrome is a rare autoinflammatory disorder characterized by interleukin-1ß-mediated and neutrophil-dominated inflammation. Neutrophil extracellular traps (NETs) are web-like structures of decondensed chromatin, histones, and antimicrobial peptides released by neutrophils. NETs were initially described in the context of pathogen defense but are also involved in autoimmune-mediated skin diseases. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438918PMC
March 2019
1 Read

Use of the Patient Benefit Index to monitor treatment of chronic spontaneous urticaria with omalizumab.

Dermatol Ther 2019 Apr 9:e12902. Epub 2019 Apr 9.

Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.1111/dth.12902DOI Listing
April 2019
2 Reads

Morbidity Associated with Chronic Infection: A Systematic Review and Meta-Analysis.

Am J Trop Med Hyg 2019 Apr 8. Epub 2019 Apr 8.

IRCCS Sacro Cuore Don Calabria Hospital, Verona, Italy.

, a worldwide-distributed soil-transmitted helminth, causes chronic infection which may be life threatening. Limitations of diagnostic tests and nonspecificity of symptoms have hampered the estimation of the global morbidity due to strongyloidiasis. This work aimed at assessing -associated morbidity through a systematic review and meta-analysis of the available literature. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0895DOI Listing
April 2019
2 Reads

A step beyond the hygiene hypothesis-immune-mediated classes determined in a population-based study.

BMC Med 2019 Apr 9;17(1):75. Epub 2019 Apr 9.

Department of Psychiatry, Center for Research in Psychiatric Epidemiology and Psychopathology, Lausanne University Hospital, Prilly, Switzerland.

Background: Comorbidity patterns of childhood infections, atopic diseases, and adverse childhood experiences (ACE) are related to immune system programming conditions. The aim of this study was to make a step beyond the hygiene hypothesis and to comprehensively classify these patterns with latent class analysis (LCA). A second aim was to characterize the classes by associations with immunological, clinical, and sociodemographic variables. Read More

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http://dx.doi.org/10.1186/s12916-019-1311-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454751PMC
April 2019
1 Read
7.249 Impact Factor

The use of omalizumab for treatment-refractory chronic spontaneous urticaria in a West Australian outpatient cohort.

Intern Med J 2019 Apr;49(4):526-528

Immunology Department, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.

There is a lack of real-world data on the use of omalizumab in treatment-refractory chronic spontaneous urticaria (CSU). A single-centre retrospective cohort study was performed to assess the efficacy and safety of omalizumab for treatment-refractory CSU. The overall response rate of 67% is comparable with that reported in the literature. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/imj.14245
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http://dx.doi.org/10.1111/imj.14245DOI Listing
April 2019
1 Read

Triggering atrial fibrillation after omalizumab injection in a patient with chronic spontaneous urticarial. A case report.

Authors:
Songul Cildag

Med Pharm Rep 2019 Jan 15;92(1):91-93. Epub 2019 Jan 15.

Immunology-Allergy Department, Adnan Menderes University, Turkey.

Introduction: Omalizumab is recommended as a third-line treatment in the treatment of chronic spontaneous urticaria. During omalizumab use, which has high efficacy and safety, the side effects observed are usually moderate and temporary. Here we discuss the triggering of atrial fibrillation following omalizumab injection. Read More

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http://dx.doi.org/10.15386/cjmed-1082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448490PMC
January 2019
1 Read

Learnings from real-life experience of using omalizumab for chronic urticaria in Latin America.

World Allergy Organ J 2019 23;12(2):100011. Epub 2019 Feb 23.

Respiralab, Respiralab Research Group, Guayaquil, Ecuador.

Background: Updated urticaria guidelines recommend that patients should be assessed for disease activity, severity, control, and quality of life at baseline and follow up. Regarding treatment, guidelines consider second generation antihistamines as the cornerstone in therapy for chronic urticaria (CU), while other drugs, such as omalizumab, are conceived as second-line alternatives. In regards to omalizumab, despite advances in the management of CU, there are still open questions about timing, dosing, and objective measures for clinical response. Read More

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http://dx.doi.org/10.1016/j.waojou.2019.100011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439401PMC
February 2019
4 Reads

Validation of the Turkish version of the Urticaria Control Test: Correlation with other tools and comparison between spontaneous and inducible chronic urticaria.

World Allergy Organ J 2019 26;12(1):100009. Epub 2019 Jan 26.

Dermatological Allergology, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Germany.

Background: The urticaria control test (UCT) is a questionnaire designed to determine if chronic urticaria (CU) is controlled or not and to aid therapeutic decision-making. It collects retrospective information about the symptoms and quality of life impairment over the last 4 weeks. The current study aimed to investigate the validity, reliability and sensitivity to change of the Turkish version of the UCT. Read More

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http://dx.doi.org/10.1016/j.waojou.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439411PMC
January 2019
2 Reads

European S2k Guideline on Chronic Pruritus.

Acta Derm Venereol 2019 Apr;99(5):469-506

Occupational Dermatology, Department of Dermatology, Ruprecht-Karls University Heidelberg, Voßstr. 2, DE-69115 Heidelberg, Germany. E-mail:

Pruritus is a frequent symptom in medicine. Population-based studies show that every 5th person in the general population has suffered from chronic pruritus at least once in the lifetime with a 12-month incidence of 7%. In patient populations its frequency is much higher depending on the underlying cause, ranging from around 25% in haemodialysis patients to 100% in skin diseases such as urticaria and atopic dermatitis (AD). Read More

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http://dx.doi.org/10.2340/00015555-3164DOI Listing
April 2019
2 Reads

Bias in the use of a SSC/CCR3 gate to capture basophils in chronic urticaria?

Immunobiology 2019 Mar 23. Epub 2019 Mar 23.

Azienda Ospedaliera Universitaria Integrata (AOUI), Section Immunology, Verona, Italy.

A comment on D'Auria E., De Amici M., Licari A. Read More

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http://dx.doi.org/10.1016/j.imbio.2019.03.003DOI Listing
March 2019
2 Reads
3.044 Impact Factor

Chronic Urticaria: An Overview of Treatment and Recent Patents.

Recent Pat Inflamm Allergy Drug Discov 2019 Mar 28. Epub 2019 Mar 28.

The Institute of Integrative Medicine, The Chinese University of Hong Kong, Shatin. Hong Kong.

Background: Up to 1% of the general population in the USA and Europe have chronic urticaria (CU) at some point in their lifetime. CU has an adverse effect on quality of life.

Objective: To provide an update on the epidemiology, pathogenesis, clinical manifestations, diagnosis, aggravating factors, complications, treatment and prognosis of CU. Read More

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http://dx.doi.org/10.2174/1872213X13666190328164931DOI Listing
March 2019
1 Read

Drug reaction with eosinophilia and systemic symptoms in a cohort of Asian children.

Pediatr Dermatol 2019 Mar 28. Epub 2019 Mar 28.

Dermatology Service, KK Women's and Children's Hospital, Singapore, Singapore.

Background/objectives: Drug reaction with eosinophilia and systemic symptoms (DRESS) is rare but potentially fatal in children. Fever and rash, which are salient features of DRESS, may mimic other commonly encountered pediatric conditions. We profiled the DRESS cases in a tertiary children's hospital in Singapore. Read More

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http://dx.doi.org/10.1111/pde.13812DOI Listing
March 2019
1 Read

Anaesthetic management of patients with pre-existing allergic conditions: a narrative review.

Br J Anaesth 2019 Mar 12. Epub 2019 Mar 12.

Department of Anaesthesia and Peri-operative Medicine, Auckland City Hospital, Auckland, New Zealand.

This narrative review seeks to distinguish the clinical patterns of pre-existing allergic conditions from other confounding non-allergic clinical entities, and to identify the potential related risks and facilitate their perioperative management. Follow-up investigation should be performed after a perioperative immediate hypersensitivity to establish a diagnosis and provide advice for subsequent anaesthetics, the main risk factor for perioperative immunoglobulin E (IgE)-mediated anaphylaxis being a previous uninvestigated perioperative immediate hypersensitivity reaction. The concept of cross-reactivity between drugs used in the perioperative setting and food is often quoted, but usually not supported by evidence. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00070912193006
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http://dx.doi.org/10.1016/j.bja.2019.01.020DOI Listing
March 2019
7 Reads

Tumor necrosis factor-alpha and Fas/Fas ligand signaling pathways in chronic spontaneous urticaria.

Allergy Asthma Clin Immunol 2019 14;15:15. Epub 2019 Mar 14.

1Clinical Department of Internal Diseases, Dermatology and Allergology, SMDZ in Zabrze, Medical University of Silesia in Katowice, ul. M. Curie-Skłodowskiej 10, 41-800 Zabrze, Poland.

Background: There is increasing evidence pointing to the important role of tumor necrosis factor-alpha (TNF-α), a key inflammatory and apoptotic mediator in urticarial inflammation. However, the role of the TNF-α system and Fas/Fas ligand (FasL) in the apoptosis-inducing pathways in chronic spontaneous urticaria (CSU), remain unclear.

Aim: To determine circulating concentrations of TNF-α, soluble TNF-α receptor type 1 and type 2 (sTNF-R1 and sTNF-R2, respectively) as well as soluble Fas (sFas) and FasL (sFasL) in CSU subjects. Read More

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https://aacijournal.biomedcentral.com/articles/10.1186/s1322
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http://dx.doi.org/10.1186/s13223-019-0332-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417283PMC
March 2019
5 Reads

Eosinophils mediate basophil-dependent allergic skin inflammation in mice.

J Invest Dermatol 2019 Mar 22. Epub 2019 Mar 22.

Department of Infection Biology, University Hospital Erlangen and Friedrich-Alexander University Erlangen-Nuremberg (FAU), 91054 Erlangen, Germany. Electronic address:

The mechanisms leading to allergic skin inflammation such as atopic dermatitis or urticaria are poorly defined. Here, we used a mouse model for IgE-dependent chronic allergic inflammation (IgE-CAI) to study the role of basophils and eosinophils for induction of pathology. FcεRI expression in basophils was required for the ear swelling response and basophils promoted the expression of eosinophil recruiting chemokines in the ear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X193133
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http://dx.doi.org/10.1016/j.jid.2019.03.1129DOI Listing
March 2019
3 Reads

[What is neutrophilic urticaria?]

Ann Dermatol Venereol 2019 Mar 23. Epub 2019 Mar 23.

Service de dermatologie et d'allergologie, HUEP, Sorbonne Universités, hôpital Tenon, AP-HP, 4, rue de la Chine, 75020 Paris, France; Inserm U1135, centre d'immunologie et des maladies infectieuses - Paris (Cimi-Paris), 75013 Paris, France.

Some debate continues to surround the existence of neutrophilic urticaria (NU) as a nosological entity. Certain authors consider NU as a banal form of urticaria since an infiltrate predominantly made up of polynuclear neutrophils (PNN) is seen in certain cases of chronic and acute urticaria. Moreover, it has been stated that the histological appearance of chronic urticaria varies according to the time between appearance of the plaque and the performance of biopsy: the presence of PNN may occur later. Read More

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http://dx.doi.org/10.1016/j.annder.2019.01.019DOI Listing
March 2019
2 Reads

Association of positive and negative autologous serum skin test responses with clinical features of chronic spontaneous urticaria in Asian patients: A systematic review and meta-analysis.

Exp Ther Med 2019 Apr 13;17(4):2603-2613. Epub 2019 Feb 13.

Department of Dermatology, No. 1 Hospital of China Medical University and Key Laboratory of Immunodermatology, Ministry of Health and Ministry of Education, Shenyang, Liaoning 110001, P.R. China.

Previous studies on the correlation between positive autologous serum skin test (ASST) responses and the clinical features of patients with chronic spontaneous urticaria (CSU) have provided conflicting results. To evaluate the significance of ASST responses in CSU, a variety of databases were searched from inception to March 2018 to identify relevant studies on CSU. Data were analyzed with use of the Cochrane Collaboration's Review Manager 5. Read More

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http://dx.doi.org/10.3892/etm.2019.7266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425266PMC
April 2019
1 Read

[Chronic superficial urticaria associated with solid cancers: Case report and literature review].

Ann Dermatol Venereol 2019 Mar 21. Epub 2019 Mar 21.

Service de médecine interne et maladies vasculaires, CHU, 49000 Angers, France. Electronic address:

Background: Chronic urticaria is common and is generally idiopathic ("spontaneous"). Links between solid cancer and chronic urticaria have been mentioned in the literature.

Patients And Methods: We report the case of a 63-year-old man presenting with superficial chronic urticaria associated with adenocarcinoma of the ethmoid sinus. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01519638193005
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http://dx.doi.org/10.1016/j.annder.2019.01.016DOI Listing
March 2019
7 Reads

Patient experiences of using Chinese herbal medicine for psoriasis vulgaris and chronic urticaria: A qualitative study.

J Dermatolog Treat 2019 Mar 21:1-28. Epub 2019 Mar 21.

a China-Australia International Research Centre for Chinese Medicine, & School of Health and Biomedical Sciences, RMIT University , PO Box 71, Bundoora Campus , Melbourne , VIC 3083 , Australia.

Background: Psoriasis vulgaris and chronic urticaria are common skin conditions with a significant health burden. Achieving long-term control remains a challenge, and some patients choose Chinese herbal medicine (CHM) to meet this need. Little is known about the motivators and experiences of using CHM for these skin conditions. Read More

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http://dx.doi.org/10.1080/09546634.2019.1591580DOI Listing
March 2019
1 Read

Chronic Urticaria in the Real-Life Clinical Practice Setting in Portugal: Baseline Results from the Non-Interventional Multicentre AWARE Study.

Acta Med Port 2019 Feb 28;32(2):133-140. Epub 2019 Feb 28.

Novartis Farma - Produtos Farmacêuticos, S.A. Porto Salvo. Portugal.

Introduction: There is a paucity of information regarding chronic urticaria patients' care in a real-world setting. The objective of this study was to report and evaluate the baseline characteristics of Portuguese chronic urticaria patients refractory to H1-antihistamines included in the AWARE study.

Material And Methods: This is a non-interventional cohort study. Read More

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http://dx.doi.org/10.20344/amp.9496DOI Listing
February 2019
3 Reads

Allergy to food additives.

Curr Opin Allergy Clin Immunol 2019 Mar 15. Epub 2019 Mar 15.

Division of Allergy, University Department of Pediatrics, Pediatric Hospital Bambino Gesù, Rome, Vatican City, Italy.

Purpose Of Review: To provide an update of the studies concerning the diagnosis and management of food additives allergy.

Recent Findings: Additives improve specific characteristics of food products, but they may induce allergic even life-threatening reactions. Physical examination and medical history are basic to assess specific in-vivo and in-vitro tests. Read More

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http://dx.doi.org/10.1097/ACI.0000000000000528DOI Listing
March 2019
1 Read

infection as a reversible cause of chronic urticaria.

J Asthma Allergy 2019 26;12:67-69. Epub 2019 Feb 26.

Department of Allergy, Immunology and Respiratory Medicine, Alfred Health, Melbourne, VIC, Australia,

Recurrent urticaria is a frequent presenting complaint in the Allergy Clinic, despite the fact that chronic urticaria is not an IgE-mediated (atopic) condition in most cases. We present four cases assessed over 5 years in our allergy service who were found to have evidence of strongyloidiasis and whose clinical features resolved with standard anti-helminth treatment. Read More

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http://dx.doi.org/10.2147/JAA.S167292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396652PMC
February 2019
1 Read

A Sea Change in the Treatment of Chronic Urticaria.

Actas Dermosifiliogr 2019 Mar 14. Epub 2019 Mar 14.

Servicio de Dermatología, Hospital del Mar, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Universitat Autònoma de Barcelona, Barcelona, España. Electronic address:

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http://dx.doi.org/10.1016/j.ad.2018.11.003DOI Listing
March 2019
1 Read

Effects of an Oral CRTh2 Antagonist (AZD1981) on Eosinophil Activity and Symptoms in Chronic Spontaneous Urticaria.

Int Arch Allergy Immunol 2019 Mar 15:1-10. Epub 2019 Mar 15.

Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Background: Approximately 50% of patients with chronic spontaneous urticaria (CSU) experience symptoms that are not fully controlled by antihistamines, indicating an unmet clinical need.

Objective: To evaluate the effects of the selective CRTh2 antagonist AZD1981 on symptoms and targeted leukocytes in adults with persistent CSU despite treatment with H1-antihistamines.

Methods: We performed a single-center, randomized, placebo-controlled study involving adult CSU subjects with symptoms despite daily antihistamines. Read More

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http://dx.doi.org/10.1159/000496162DOI Listing
March 2019
1 Read

Effective treatment of different H1-antihistamine-refractory chronic urticaria phenotypes with omalizumab.

Turk Pediatri Ars 2018 Dec 1;53(4):250-254. Epub 2018 Dec 1.

Department of Pediatrics, Division of Pediatric Allergy and Immunology, Adnan Menderes University School of Medicine, Aydın, Turkey.

Omalizumab is a recombinant humanized monoclonal anti-IgE antibody. Until now, the efficiency of omalizumab in chronic spontaneous urticaria has been demonstrated in several studies. However in the literature, data showing the efficiency of omalizumab in different phenotypes of H1-antihistamine-refractory chronic urticaria are limited. Read More

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http://dx.doi.org/10.5152/TurkPediatriArs.2016.4042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408194PMC
December 2018
1 Read

Prevalence Estimates For Chronic Urticaria in the United States: a gender and age adjusted population analysis.

J Am Acad Dermatol 2019 Mar 11. Epub 2019 Mar 11.

Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra / Northwell, New Hyde Park, NY. Electronic address:

Background: Disease burden in chronic urticaria (CU) is poorly understood.

Objective: To estimate standardized overall and gender-, age-, and race-specific prevalence estimates for CU among adults in the United States.

Methods: Cross-sectional analysis using electronic health records data for a demographically heterogeneous population-based sample of over 55 million patients across all four census regions. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.02.064DOI Listing

Does omalizumab treatment affect serum dehydroepiandrosterone sulphate levels in chronic idiopathic urticaria?

Postepy Dermatol Alergol 2019 Feb 22;36(1):92-97. Epub 2019 Feb 22.

Department of Dermatology and Venereology, University of Health Science, Kayseri Health Training and Research Hospital, Kayseri, Turkey.

Introduction: It is known that serum dehydroepiandrosterone sulphate (DHEA-S) levels are low in patients with chronic idiopathic urticaria.

Aim: In the study, the effect of the drug on the DHEA-S serum levels and its correlation with the remission and relapse times of the disease was investigated.

Material And Methods: Fifty-seven patients with chronic idiopathic urticaria who were referred to our hospital and 20 healthy volunteers were included in the study. Read More

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http://dx.doi.org/10.5114/ada.2018.75328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409887PMC
February 2019
1 Read

Efficacy and safety of bilastine in reducing pruritus in patients with chronic spontaneous urticaria and other skin diseases: an exploratory study.

J Dermatolog Treat 2019 Mar 5:1-9. Epub 2019 Mar 5.

f Medical Department , FAES FARMA S. A. , Bizkaia , Spain.

Purpose: To evaluate the efficacy/safety of bilastine in pruritus relief in patients with chronic spontaneous urticaria (CSU) or other pruritic skin diseases.

Methods: In this multicenter, open-label, exploratory study (EudraCT No.: 2016-001505-17), 115 adults with CSU (n = 34), eczema/dermatitis (n = 30), prurigo (n = 25) or cutaneous pruritus (n = 26), received bilastine 20 mg once daily for 8 weeks, or in non-responder patients (<30% improvement in pruritus score at week 2), 40 mg/day from week 2. Read More

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https://www.tandfonline.com/doi/full/10.1080/09546634.2019.1
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http://dx.doi.org/10.1080/09546634.2019.1590522DOI Listing
March 2019
6 Reads

Eosinophilic oesophagitis (in nickel-allergic patient) regressed after nickel oral desensitization: A case report.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738419827771

3 Endoscopic Digestive Surgery, IRCCS Fondazione Policlinico Universitario Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy.

The eosinophilic oesophagitis (EoE) is a chronic immune/antigen disorder of the oesophagus clinically characterized by dysphagia and pathologically by mucosa eosinophilic infiltration. Th2-type allergic reactions are considered having important roles in the aetiopathogenesis of EoE. Avoidance of food allergens, administration of steroidal anti-inflammatory medications and dilation of the oesophagus are the most important treatments. Read More

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http://dx.doi.org/10.1177/2058738419827771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407324PMC
March 2019
8 Reads

Chronic spontaneous urticaria and angioedema requiring treatment with omalizumab in a patient with hereditary angioedema.

Ann Allergy Asthma Immunol 2019 Mar 1. Epub 2019 Mar 1.

Immunology Department, St Helier Hospital, Surrey, United Kingdom.

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http://dx.doi.org/10.1016/j.anai.2019.02.019DOI Listing
March 2019
2 Reads

Hypersensitivity reactions to food and drug additives: problem or myth?

Acta Biomed 2019 Jan 29;90(3-S):80-90. Epub 2019 Jan 29.

Pediatric Unit, Department of Medical and Surgical Sciences, University of Bologna, S. Orsola-Malpighi Hospital.

Background And Aim Of The Work: The possibility of an allergic reaction or an intolerance to additives is frequently suspected by parents, especially for chronic illness with frequent exacerbations such as atopic dermatitis or chronic urticaria. For more than 50 years, potential adverse reactions to additives have been suggested, but to date data are conflicting. The purpose of this article is to provide the clinicians with general information about additives and adverse reactions to them and to suggest a practical approach to children suspected to have reactions to food additives. Read More

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http://dx.doi.org/10.23750/abm.v90i3-S.8168DOI Listing
January 2019
4 Reads

Chronic urticaria and drug hypersensitivity in children.

Acta Biomed 2019 Jan 29;90(3-S):61-65. Epub 2019 Jan 29.

Clinica Pediatrica, Dipartimento di Medicina e Chirurgia, Azienda Ospedaliero-Universitaria, Università di Parma, Italy.

The cause of chronic urticaria remains often elusive. The association between chronic urticaria and intake of medications have been reported in children. However, the causative role of drugs has been rarely ascertained by onset of symptoms on drug provocation test. Read More

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http://dx.doi.org/10.23750/abm.v90i3-S.8166DOI Listing
January 2019
3 Reads

The burden of chronic urticaria: French baseline data from the international real-life AWARE study.

Eur J Dermatol 2019 Feb;29(1):49-54

Dermatology Department, Larrey Hospital, CHU Toulouse, Toulouse, France.

Background: The AWARE study is an ongoing international study of patients with chronic urticaria refractory to H1-antihistamines. The aim of this study is to evaluate the burden of disease and the use of healthcare resources in real-life conditions.

Objectives: To analyse the baseline data of French patients included in the AWARE study. Read More

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http://dx.doi.org/10.1684/ejd.2018.3495DOI Listing
February 2019
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Biologics for chronic inflammatory skin diseases: an update for the clinician.

J Dermatolog Treat 2019 Mar 2:1-23. Epub 2019 Mar 2.

a Department of Dermato-Venereology and Wound Healing Centre , Bispebjerg Hospital , Copenhagen , Denmark.

The introduction and continuous development in biological drugs has greatly improved the therapeutic quality for patients with chronic inflammatory skin conditions. Current approaches to the biologic treatment of psoriasis, atopic dermatitis, chronic spontaneous urticaria, and hidradenitis suppurativa include licensed use of traditional antitumor necrosis factor agents, selective interleukin antagonists (IL-4, IL-12/23, IL-17), and the IgE inhibitor omalizumab, and as the knowledge on the pathogenesis of these diseases expands, off-label uses of the currently available biologics are becoming increasingly attractive, and the number of investigational drugs is growing progressively plentiful. In recent years, small molecule inhibitors, many of which are used in cancer therapy, have emerged as valuable future prospects in the treatment of inflammatory diseases. Read More

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http://dx.doi.org/10.1080/09546634.2019.1589643DOI Listing
March 2019
4 Reads

Effects of Desloratadine Citrate Disodium on Serum Immune Function Indices, Inflammatory Factors and Chemokines in Patients with Chronic Urticaria.

J Coll Physicians Surg Pak 2019 Mar;29(3):214-217

Department of Dermatology, Shaanxi Provincial Hospital of Traditional Chinese Medicine, Xi'an, 710003, China.

Objective: To determine the effects of desloratadine citrate disodium on serum immunological function indices (IgE, C3 and C4), inflammatory factors (IL-4, IL-17 and IL-33), and chemokines (MCP-1, RANTES and Eotaxin) in patients with chronic urticaria.

Study Design: An experimental study.

Place And Duration Of Study: Department of Dermatology, Shaanxi Provincial Hospital of Traditional Chinese Medicine, Xi'an, China, from January 2017 to January 2018. Read More

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http://dx.doi.org/10.29271/jcpsp.2019.03.214DOI Listing
March 2019
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Real-life data on the effectiveness and safety of omalizumab in monotherapy or combined for chronic spontaneous urticaria: a retrospective cohort study.

J Dermatolog Treat 2019 Mar 1:1-6. Epub 2019 Mar 1.

b Department of Dermatology , Hospital del Mar, IMIM, Universitat Autònoma , Barcelona , Spain.

Background: The real-life data on the effectiveness and safety of omalizumab in chronic spontaneous urticaria (CSU) with validated methods are scarce. There is also a lack of information on the use of combination treatments.

Methods: A retrospective cohort study was done to evaluate the effectiveness and safety of omalizumab in real-life conditions. Read More

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http://dx.doi.org/10.1080/09546634.2019.1589639DOI Listing
March 2019
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Serum miR-125a-5p and CCL17 Upregulated in Chronic Spontaneous Urticaria and Correlated with Treatment Response.

Acta Derm Venereol 2019 02 27. Epub 2019 Feb 27.

Department of Dermatology, No. 1 Hospital of China Medical University, 155 North Nanjing Street, Shenyang 110001, China.

Chronic spontaneous urticaria (CSU) is a common skin disorder associated with autoimmunity. MicroRNAs (miRNAs) are endogenous noncoding RNA molecules reported to be potential biomarkers for some autoimmune diseases. In this study, we investigated the association of miRNAs with CSU. Read More

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http://dx.doi.org/10.2340/00015555-3149DOI Listing
February 2019
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On the Lipophilic Nature of Autoreactive IgE in Chronic Spontaneous Urticaria.

Theranostics 2019 25;9(3):829-836. Epub 2019 Jan 25.

Dept. of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Germany.

Chronic spontaneous urticaria (CSU) is a skin disease related to autoreactive IgE in at least a subgroup of patients. However, the nature of this autoreactive IgE remains poorly characterized. This investigation had three objectives: first, to quantity CSU autoreactive IgE; second, to recognize the patterns of CSU autoreactive IgE compared with healthy control IgE; and third, to investigate the physiochemical nature of CSU autoreactive IgE. Read More

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http://dx.doi.org/10.7150/thno.29902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376472PMC
January 2019
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Differentiation between control subjects and patients with chronic spontaneous urticaria based on the ability of anti-IgE autoantibodies (AAbs) to induce FcεRI crosslinking, as compared to anti-FcεRIα AAbs.

Allergol Int 2019 Feb 22. Epub 2019 Feb 22.

Allergy and Immunology Research Project Team, Nihon University School of Medicine, Tokyo, Japan; Center for Institutional Research and Medical Education, Nihon University School of Medicine, Tokyo, Japan. Electronic address:

Background: The reported prevalences of IgG autoantibodies (AAbs) to FcεRIα and IgE in sera from patients with chronic spontaneous urticaria (CSU) have varied, and these AAbs are also often observed in healthy control subjects. Regarding the histamine release activity of purified IgG from patients with CSU, the number of examined patients has been small. Thus, we sought to determine the prevalence and FcεRI crosslinking ability of these AAbs in a large number of patients with CSU and non-atopic control (NC) subjects. Read More

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http://dx.doi.org/10.1016/j.alit.2019.01.003DOI Listing
February 2019
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Total IgE and atopic status in patients with severe chronic spontaneous urticaria unresponsive to omalizumab treatment.

Allergy 2019 Feb 23. Epub 2019 Feb 23.

Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milan, Italy.

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http://dx.doi.org/10.1111/all.13754DOI Listing
February 2019

Characterization of chronic urticaria and associated conditions in a large population of adolescents.

J Am Acad Dermatol 2019 Feb 21. Epub 2019 Feb 21.

Allergy and Clinical Immunology Unit, Meir General Hospital, Kfar-Saba, Israel; Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Background: Although chronic spontaneous urticaria (CSU) affects all age groups, data regarding CSU in adolescents is scarce.

Objective: To characterize the epidemiology, demographics and co-morbidities associated with CSU in a large cross-sectional, nationwide, population of adolescents.

Methods: Medical records of 16-year-old candidate conscripts to the Israeli Defense Forces were reviewed. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.02.034DOI Listing
February 2019
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Exploring the real-world profile of refractory and non-refractory chronic idiopathic urticaria in the USA: clinical burden and healthcare resource use.

Curr Med Res Opin 2019 Feb 22:1-9. Epub 2019 Feb 22.

b Health Economics and Outcomes Research , Novartis Pharmaceuticals Corporation , East Hanover , NJ , USA.

Introduction: Chronic idiopathic/spontaneous urticaria (CIU/CSU) is a debilitating skin condition that is burdensome for patients and healthcare providers. We aimed to describe clinical characteristics, consultation patterns and healthcare resource utilization in real-world US patients with refractory and non-refractory CIU/CSU.

Methods: Data was collected from the Adelphi Real World 2015 Urticaria Disease Specific Programme. Read More

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http://dx.doi.org/10.1080/03007995.2019.1586222DOI Listing
February 2019
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Dissociating polysensitization and multimorbidity in children and adults from a Polish general population cohort.

Clin Transl Allergy 2019 11;9. Epub 2019 Feb 11.

1Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, Poland.

Background: Links between multimorbidity of allergic diseases and allergen sensitization are still under debate, especially in adults. This study aimed to establish a relationship between polysensitization and allergic multimorbidity in children and adults and the allergens involved in multimorbidity.

Material And Method: A cross-sectional multicentre study enrolled children aged 6-7 and 13-14 years and adults aged 20-44 years from a Polish national cohort. Read More

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http://dx.doi.org/10.1186/s13601-019-0246-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369558PMC
February 2019
5 Reads

Current Strategies to Inhibit High Affinity FcεRI-Mediated Signaling for the Treatment of Allergic Disease.

Authors:
Gregorio Gomez

Front Immunol 2019 7;10:175. Epub 2019 Feb 7.

Department of Pathology, Microbiology and Immunology, University of South Carolina School of Medicine, Columbia, SC, United States.

Allergies and asthma are a major cause of chronic disease whose prevalence has been on the rise. Allergic disease including seasonal rhinitis, atopic dermatitis, urticaria, anaphylaxis, and asthma, are associated with activation of tissue-resident mast cells and circulating basophils. Although these cells can be activated in different ways, allergic reactions are normally associated with the crosslinking of the high affinity Fc receptor for Immunoglobulin E, FcεRI, with multivalent antigen. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374298PMC
February 2019
2 Reads

Basophil count is a sensitive marker for clinical progression in a chronic spontaneous urticaria patient treated with omalizumab.

Allergol Int 2019 Feb 18. Epub 2019 Feb 18.

Department of Dermatology, Kansai Medical University, Hirakata, Japan.

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http://dx.doi.org/10.1016/j.alit.2019.02.002DOI Listing
February 2019
1 Read