297 results match your criteria Urticaria Cholinergic


Exercise-induce anaphylaxis, food-dependent exercise-induce anaphylaxis, cholinergic urticaria and Kounis syndrome.

Neth J Med 2019 Jan;77(1):38-39

Department of Cardiology, University of Patras Medical School, Rion, Patras, Achaia, Greece.

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January 2019
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Efficacy and Safety of Omalizumab (Xolair) for Cholinergic Urticaria in Patients Unresponsive to a Double Dose of Antihistamines: A Randomized Mixed Double-Blind and Open-Label Placebo-Controlled Clinical Trial.

J Allergy Clin Immunol Pract 2019 Jan 15. Epub 2019 Jan 15.

Department of Allergy and Clinical Immunology, Clinica Universidad de Navarra, Pamplona, Spain; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain; RETIC de Asma, Reacciones adversas y Alérgicas (ARADYAL), Madrid, Spain. Electronic address:

Background: Cholinergic urticaria (UCOL) is a highly disabling inducible urticaria triggered by an increase in core body temperature.

Objective: To explore the safety and efficacy of omalizumab in controlling UCOL.

Methods: We conducted a multicenter randomized mixed double-blind and open-label (first 4 months blinded followed by 8 months open-label) placebo-controlled clinical trial in 22 patients suffering from UCOL who were unresponsive to a double dose of antihistamines. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.12.025DOI Listing
January 2019
6 Reads

Use of antipsychotic drugs in dermatology.

Clin Dermatol 2018 Nov - Dec;36(6):765-773. Epub 2018 Aug 16.

Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Antipsychotic drugs can be beneficial in dermatology because of their both central nervous system and peripheral effects. All antipsychotic drugs have a central postsynaptic dopamine D2 receptor blocking effect, which underlies their antipsychotic action. The antipsychotic drugs have varying degrees of histamine H1-receptor, cholinergic muscarinic receptor, and α1-adrenergic receptor blocking effects, which can affect cutaneous perception and the autonomic reactivity of the skin and can be potentially beneficial in the management of certain histamine or sympathetically mediated dermatologic manifestations (eg, urticaria, pruritus, hyperhidrosis). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0738081X183017
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http://dx.doi.org/10.1016/j.clindermatol.2018.08.006DOI Listing
March 2019
26 Reads

Omalizumab in Chronic Urticaria: An Italian Survey.

Int Arch Allergy Immunol 2019;178(1):45-49. Epub 2018 Nov 5.

Clinical Dermatology, IRCCS Istituto Ortopedico Galeazzi, Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.

Omalizumab is approved for use in chronic spontaneous urticaria (CSU); however, it is not approved for chronic inducible urticaria (CIndU). The aim of the present study was to assess the effectiveness of omalizumab in treating CSU and CIndU in Italy. This is a multicentre prospective observational real-life study involving patients with severe urticaria capable of undergoing omalizumab therapy. Read More

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https://www.karger.com/Article/FullText/492532
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http://dx.doi.org/10.1159/000492532DOI Listing
April 2019
24 Reads

Drug eruption by antihistamine mistaken for chronic urticaria in a child.

Korean J Pediatr 2019 Feb 30;62(2):75-78. Epub 2018 Oct 30.

Department of Pediatrics, Kangwon National University Hospital, chuncheon, Korea.

Although rare, antihistamines can cause adverse effects, including drug-induced eruptions or anaphylaxis. A 4-year-old child visited the pediatric department of a hospital for skin eruptions after administration of antihistamines, (e.g. Read More

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http://kjp.or.kr/journal/view.php?doi=10.3345/kjp.2018.06695
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http://dx.doi.org/10.3345/kjp.2018.06695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382964PMC
February 2019
26 Reads

Angioedema frequently occurs in cholinergic urticaria.

J Allergy Clin Immunol Pract 2019 Apr 25;7(4):1355-1357.e1. Epub 2018 Oct 25.

Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1016/j.jaip.2018.10.013DOI Listing
April 2019
4 Reads

Real-life treatment of cholinergic urticaria with omalizumab.

J Allergy Clin Immunol 2019 Feb 9;143(2):788-791.e8. Epub 2018 Oct 9.

Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1016/j.jaci.2018.08.050DOI Listing
February 2019
19 Reads

Clinico-epidemiological features of chronic urticaria in children: A retrospective analysis of 296 children from a tertiary care institute in Northern India.

Indian J Dermatol Venereol Leprol 2018 Sep 25. Epub 2018 Sep 25.

Department of Dermatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Background: Urticaria is a common dermatosis affecting approximately 25% of the population. Childhood chronic urticaria is frequently encountered, however, epidemiologic data on pediatric urticaria are limited.

Aim: The objective of this study was to study the clinico-epidemiological profile of children with chronic urticaria. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_573_17DOI Listing
September 2018
3 Reads
1.325 Impact Factor

Primum non nocere: Anticholinergics and dementia.

Authors:
Dirk M Elston

J Am Acad Dermatol 2018 09;79(3):439-440

Department of Dermatology and Dermatologic Surgery Medical University of South Carolina, Charleston, South Carolina. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183046
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http://dx.doi.org/10.1016/j.jaad.2018.03.016DOI Listing
September 2018
8 Reads

Sweat allergy.

Allergol Int 2018 Oct 31;67(4):435-441. Epub 2018 Jul 31.

Department of Dermatology, Graduate School of Biomedical and Health Sciences, Hiroshima University 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan. Electronic address:

Sweat allergy is defined as a type I hypersensitivity against the contents of sweat, and is specifically observed in patients with atopic dermatitis (AD) and cholinergic urticaria (CholU). The allergic reaction is clinically revealed by positive reactions in the intradermal skin test and the basophil histamine release assay by sweat. A major histamine-releasing antigen in sweat, MGL_1304, has been identified. Read More

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http://dx.doi.org/10.1016/j.alit.2018.07.002DOI Listing
October 2018
8 Reads

How to Approach Chronic Inducible Urticaria.

J Allergy Clin Immunol Pract 2018 Jul - Aug;6(4):1119-1130

Division of Allergy and Immunology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Tex.

Chronic inducible urticaria (CIndU) is a group of chronic urticarias characterized by the appearance of recurrent wheals, recurrent angioedema or both, as a response to specific triggers. CIndU includes both physical (symptomatic dermographism, cold and heat urticaria, delayed pressure urticaria, solar urticaria, and vibratory urticaria) and nonphysical urticarias (cholinergic urticaria, contact and aquagenic urticaria). Here, we review the different forms of CIndU with an emphasis on symptomatic dermographism, cold urticaria, cholinergic urticaria, and delayed pressure urticaria. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.03.007DOI Listing
March 2018
59 Reads

Epidemiology of urticaria including physical urticaria and angioedema in Korea.

Korean J Intern Med 2019 Mar 11;34(2):418-425. Epub 2018 May 11.

Department of Internal Medicine, Kangwon National University Hospital, Chuncheon, Korea.

Background/aims: Despite the high burden and frequency of urticaria, its epidemiology is not well known. We investigated the epidemiology of various type of urticaria in Korea and changes in its annual prevalence over 5 years.

Methods: We used data from the 2010 to 2014 Health Insurance Review and Assessment database, which covers the claims of 97. Read More

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http://dx.doi.org/10.3904/kjim.2017.203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406086PMC
March 2019
4 Reads

Chronic inducible urticaria: A systematic review of treatment options.

J Allergy Clin Immunol 2018 May 10;141(5):1726-1734. Epub 2018 Feb 10.

Department of Dermatology, Venerology and Allergy, Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. Electronic address:

Background: Chronic inducible urticaria (CindU) is a condition characterized by the appearance of recurrent wheals, angioedema, or both as a response to specific and reproducible triggers.

Objective: We sought to systematically assess evidence on the efficacy and safety of treatment options for CindU. Results were used to inform the 2017 update of "The EAACI/GALEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183022
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http://dx.doi.org/10.1016/j.jaci.2018.01.031DOI Listing
May 2018
39 Reads

Development and validation of the Cholinergic Urticaria Quality-of-Life Questionnaire (CholU-QoL).

Clin Exp Allergy 2018 Apr 28;48(4):433-444. Epub 2018 Feb 28.

Department of Dermatology and Allergy, Urticaria Center of Reference and Excellence (UCARE), Charité-Universitätsmedizin Berlin, Berlin, Germany.

Background: Cholinergic urticaria (CholU), a common form of chronic inducible urticaria, is characterized by itchy weals that occur in response to physical exercise or passive warming. CholU patients frequently exhibit a high burden of disease. As of yet, no specific instrument is available to assess their disease-related quality-of-life (QoL) impairment. Read More

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http://dx.doi.org/10.1111/cea.13102DOI Listing
April 2018
8 Reads

Aquagenic Urticaria: A Perplexing Physical Phenomenon.

Acta Dermatovenerol Croat 2017 Oct;25(3):234-237

Professor Robert A Schwartz MD, MPH, DSc (Hon), FRCP Edin Dermatology Rutgers New Jersey Medical School, 185 South Orange Avenue H-576, Newark, New Jersey 07103;

Aquagenic urticaria (AQ) is a rare physical urticaria induced by contact with water. It may be distinctive clinically, evident as 1-2 mm folliculopapular urticaria, a pattern also characteristic of cholinergic urticaria. AQ has a truncal and upper extremity distribution within 20-30 minutes after contact with water, regardless of its temperature or source. Read More

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October 2017
21 Reads

Authors:

Arerugi 2017;66(9):1185-1186

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http://dx.doi.org/10.15036/arerugi.66.1185DOI Listing
June 2018
7 Reads

Successful treatment of refractory cholinergic urticaria with omalizumab.

Int J Dermatol 2018 01 23;57(1):114. Epub 2017 Oct 23.

Dermatology Department, Royal Free London NHS Foundation Trust, London, UK.

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http://doi.wiley.com/10.1111/ijd.13808
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http://dx.doi.org/10.1111/ijd.13808DOI Listing
January 2018
8 Reads

Cholinergic urticaria patients of different age groups have distinct features.

Clin Exp Allergy 2017 Dec 10;47(12):1609-1614. Epub 2017 Oct 10.

Department of Dermatology and Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Background: Cholinergic urticaria (CholU) is a common skin disease characterized by the development of pinpoint-sized weals and severe itch upon physical exercise. Little is known about the epidemiology of CholU. CholU can occur at any age and has the highest prevalence among young adults. Read More

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http://dx.doi.org/10.1111/cea.13023DOI Listing
December 2017
9 Reads

Omalizumab treatment in patients with chronic inducible urticaria: A systematic review of published evidence.

J Allergy Clin Immunol 2018 Feb 24;141(2):638-649. Epub 2017 Jul 24.

Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Background: Omalizumab, a recombinant anti-IgE antibody, effectively treats chronic spontaneous urticaria. Evidence is lacking in patients with chronic inducible urticarias (CIndUs), which are frequently H-antihistamine resistant.

Objective: From the current published literature, we aimed to determine the strength of evidence for omalizumab efficacy and safety in the treatment of CIndUs. Read More

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http://dx.doi.org/10.1016/j.jaci.2017.06.032DOI Listing
February 2018
31 Reads

Cholinergic urticaria: Clinicoepidemiological paradigms from a tertiary care center in North India.

Indian J Dermatol Venereol Leprol 2017 Sep-Oct;83(5):599-601

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_735_16DOI Listing
November 2018
7 Reads

Case of cholinergic urticaria accompanied by anaphylaxis.

J Dermatol 2017 Nov 30;44(11):1291-1294. Epub 2017 Jun 30.

Department of Dermatology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Cholinergic urticaria occasionally occurs in combination with anaphylactic symptoms. However, this has not been widely reported. Herein, we report the case of a 14-year-old Japanese male who was diagnosed with cholinergic urticaria accompanied by anaphylaxis. Read More

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http://dx.doi.org/10.1111/1346-8138.13951DOI Listing
November 2017
26 Reads

Sweat allergy: Extrinsic or intrinsic?

J Dermatol Sci 2017 Jul 9;87(1):3-9. Epub 2017 Mar 9.

Department of Dermatology, Integrated Health Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.

Sweat is an exacerbation factor in atopic dermatitis (AD) in all age groups. A body core temperature elevation with sweating triggers cholinergic urticaria (CholU). We recently reported that AD symptoms are improved by tannic acid-containing spray, which suppresses the basophil histamine release induced by semi-purified sweat antigen in vitro, and by showering, which removes antigens in sweat from the skin surface. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2017.03.002DOI Listing
July 2017
7 Reads

Cholinergic urticaria: epidemiology, physiopathology, new categorization, and management.

Clin Auton Res 2018 02 5;28(1):103-113. Epub 2017 Apr 5.

Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.

Purpose: The aim of this study was to review the evidence on the epidemiology, physiopathology, categorization, and management of cholinergic urticaria. We specifically focused on several subtypes of cholinergic urticaria and investigated the relationship between cholinergic urticaria and idiopathic anhidrosis.

Methods: Using an integrative approach, we reviewed publications addressing the epidemiology, clinical features, diagnostic approach, physiopathology, subtype classification, and therapeutic approach to cholinergic urticaria. Read More

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http://dx.doi.org/10.1007/s10286-017-0418-6DOI Listing
February 2018
20 Reads

Evaluation of the correlation between severity of acquired idiopathic generalized anhidrosis and quality of life scores.

J Dermatol 2017 Jul 22;44(7):747-752. Epub 2017 Mar 22.

Department of Dermatology, Tokyo Medical and Dental University, Tokyo, Japan.

Symptoms of acquired idiopathic generalized anhidrosis (AIGA) include heat retention and/or heat stroke due to the effects of the disorder on the perspiration ability of the whole body under thermal environmental changes or exercise. Additionally, cholinergic urticaria can also occur in these patients. AIGA has a major impact on everyday life. Read More

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http://dx.doi.org/10.1111/1346-8138.13785DOI Listing
July 2017
15 Reads

Serum carcinoembryonic antigen specifically increases among various serum markers of adenocarcinoma in hypohidrosis or conditions related to hypohidrosis.

J Dermatol 2017 Aug 11;44(8):903-908. Epub 2017 Mar 11.

Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan.

Anhidrosis/hypohidrosis are conditions presenting various level of sweating dysfunction. Among them, acquired idiopathic generalized anhidrosis (AIGA) presents inadequate decrease or loss of sweating without apparent neurological and dermatological symptoms except cholinergic urticaria. Recently, serum level of carcinoembryonic antigen (CEA), one of the most well-known tumor markers, has been proposed as a clinical marker reflecting activity of AIGA. Read More

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http://dx.doi.org/10.1111/1346-8138.13828DOI Listing
August 2017
29 Reads

A case of cholinergic urticaria with localized hypohidrosis showing sweat gland eosinophilic infiltration.

Allergol Int 2017 Jul 18;66(3):495-496. Epub 2017 Jan 18.

Department of Dermatology, Tokyo Medical University, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.alit.2016.11.007DOI Listing
July 2017
17 Reads

Cross-reactive LTP sensitization in food-dependent exercise-induced urticaria/anaphylaxis: a pilot study of a component-resolved and in vitro depletion approach.

Clin Transl Allergy 2016 22;6:46. Epub 2016 Dec 22.

Serviço de Imunoalergologia, Centro Hospitalar São João, Porto, Portugal ; Laboratory of Immunology, Basic and Clinical Immunology Unit, Faculty of Medicine, Porto University, Porto, Portugal ; Unidade de Imunoalergologia, Unidade Local de Saúde do Alto Minho, Viana Do Castelo, Portugal ; Department of Clinical Pathology, Centro Hospitalar São João, Porto, Portugal ; CINTESIS and Biostatistics and Medical Informatics, Faculty of Medicine, University of Porto, Porto, Portugal.

Background: Challenge tests for food-dependent exercise-induced anaphylaxis (FDEIA) carry some risk and have a high rate of false negatives. Our aim was to explore the usefulness of an in vitro immunodepletion assay and an allergen microarray test in the identification of IgE-mediated cross-reactive food allergens in patients with suspected FDEIA or food-dependent exercise-induced urticaria and panallergen sensitization.

Methods: Three patients with a history of food dependent exercise induced urticaria/anaphylaxis and food panallergen sensitization in whom a food-exercise challenge was not feasible were selected: a 25-year-old man with cholinergic urticaria who experienced generalized urticaria and angioedema during a soccer match after drinking a peach-based soft drink; a 19-year-old woman with allergic rhinitis and controlled asthma who experienced anaphylactic shock while playing soccer, having eaten walnuts in the previous 90 min; and a 57-year-old man with baker's asthma who experienced four episodes of anaphylaxis during exercise after ingesting wheat-containing food. Read More

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http://dx.doi.org/10.1186/s13601-016-0136-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5180400PMC
December 2016
50 Reads

Pure Cold-Induced Cholinergic Urticaria in a Pediatric Patient.

Case Reports Immunol 2016 29;2016:7425601. Epub 2016 Nov 29.

Allergy/Immunology Associates, Inc., Mayfield Heights, OH, USA.

Cold urticaria and cholinergic urticaria are two distinct entities. The presentation of exclusive cold-induced cholinergic urticaria is very rare. The patient described herein had experienced urticaria in the exclusive setting of exercising in a cold environment. Read More

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http://dx.doi.org/10.1155/2016/7425601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153475PMC
November 2016
16 Reads

Clinical and etiologic evaluation of the children with chronic urticaria.

Allergy Asthma Proc 2016 11;37(6):450-457

Pediatric Allergy and Immunology, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey.

Background: Chronic urticaria (CU) is a skin disorder defined as daily or almost daily exhibition of pruritic and transient wheals that last for 6 weeks. CU is divided into two subtypes: chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU).

Objectives: To evaluate the clinical features, possible causes, associated findings, and laboratory results of different subtypes of CU in children according to a new classification. Read More

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November 2016
20 Reads

Clinical characteristics in cholinergic urticaria with palpebral angioedema: Report of 15 cases.

J Dermatol Sci 2017 Feb 11;85(2):135-137. Epub 2016 Nov 11.

Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.

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http://dx.doi.org/10.1016/j.jdermsci.2016.11.001DOI Listing
February 2017
15 Reads

Omalizumab in the Treatment of Chronic Inducible Urticaria.

Actas Dermosifiliogr 2017 Jun 5;108(5):423-431. Epub 2016 Oct 5.

Servicio de Dermatología, Hospital Universitario de La Princesa, Madrid, España.

Omalizumab is a recombinant humanized monoclonal antibody that inhibits immunoglobulin E. It has been approved for the treatment of severe asthma and chronic spontaneous urticaria refractory to other treatments. Its use in the management of chronic inducible urticaria (a type triggered by certain stimuli) is still considered off-label, although this use has been discussed in some consensus papers. Read More

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http://dx.doi.org/10.1016/j.ad.2016.07.018DOI Listing
June 2017
18 Reads

Inducible urticaria: Case series and literature review.

Biomedica 2016 Mar 3;36(1):10-21. Epub 2016 Mar 3.

Grupo de Alergología Clínica y Experimental (GACE), IPS Universitaria, Universidad de Antioquia, Medellín, Colombia.

Inducible urticaria is a heterogeneous group of skin disorders characterized by the appearance of wheals, pruritus and/or angioedema, sometimes accompanied by systemic symptoms caused by innocuous stimuli (cold, heat, pressure, etc.). This group of disorders compromises people's quality of life and most of the literature in this regard comes from case reports and case series since its epidemiology has been poorly studied and some cases are very rare. Read More

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http://dx.doi.org/10.7705/biomedica.v36i1.2678DOI Listing
March 2016
12 Reads

Diagnostic utility of challenge procedures for physical urticaria/angioedema syndromes: a systematic review.

Curr Opin Allergy Clin Immunol 2016 10;16(5):511-5

aDepartment of Internal MedicinebDepartment of Allergy and Clinical Immunology, Respiratory Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Purpose Of Review: Physical urticaria/angioedema syndromes (PUAs) are commonly encountered. They are identified by a history of physical factors provoking cutaneous symptoms, and confirmed by provocation testing. Recent guidelines have recommended use of challenge procedures for diagnosis; however, their positive/negative likelihood ratios have not been established. Read More

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http://dx.doi.org/10.1097/ACI.0000000000000298DOI Listing
October 2016
15 Reads

Sweat Allergy.

Curr Probl Dermatol 2016 30;51:101-8. Epub 2016 Aug 30.

For many years, sweat has been recognized as an exacerbation factor in all age groups of atopic dermatitis (AD) and a trigger of cholinergic urticaria (CholU). Recently, we reported the improvement of AD symptoms by spray with tannic acid, which suppresses basophil histamine release by semipurified sweat antigens in vitro, and showering that removes antigens in sweat from the skin surface. We finally identified MGL_1304 secreted by Malassezia globosa as a major histamine-releasing antigen in human sweat. Read More

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http://dx.doi.org/10.1159/000446788DOI Listing
April 2017
12 Reads

New Etiology of Cholinergic Urticaria.

Authors:
Yoshiki Tokura

Curr Probl Dermatol 2016 30;51:94-100. Epub 2016 Aug 30.

Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Cholinergic urticaria (CholU) is characterized by pinpoint-sized, highly pruritic wheals occurring upon sweating. Both direct and indirect theories in the interaction of acetylcholine (ACh) with mast cells have been put forward in the sweating-associated histamine release from mast cells. In the mechanism of indirect involvement of ACh, patients are hypersensitive to sweat antigen(s) and develop wheals in response to sweat substances leaking from the syringeal ducts to the dermis, possibly by obstruction of the ducts. Read More

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http://dx.doi.org/10.1159/000446787DOI Listing
April 2017
11 Reads

Clinical Analysis and Management of Acquired Idiopathic Generalized Anhidrosis.

Authors:
Takahiro Satoh

Curr Probl Dermatol 2016 30;51:75-9. Epub 2016 Aug 30.

Department of Dermatology, National Defense Medical College, Tokorozawa, Japan.

Acquired idiopathic generalized anhidrosis (AIGA) is a sweating disorder characterized by inadequate sweating in response to heat stimuli such as high temperature, humidity, and physical exercise. Patients exhibit widespread nonsegmental hypohidrosis/anhidrosis without any apparent cause, but the palms, soles, and axillae are rarely affected. Heat stroke readily develops due to increased body temperature. Read More

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http://dx.doi.org/10.1159/000446781DOI Listing
April 2017
14 Reads

Antihistamine updosing reduces disease activity in patients with difficult-to-treat cholinergic urticaria.

J Allergy Clin Immunol 2016 11 29;138(5):1483-1485.e9. Epub 2016 Jun 29.

Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S00916749163053
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http://dx.doi.org/10.1016/j.jaci.2016.05.026DOI Listing
November 2016
17 Reads

Atopic predisposition in cholinergic urticaria patients and its implications.

J Eur Acad Dermatol Venereol 2016 Dec 21;30(12):2060-2065. Epub 2016 Jun 21.

Department of Dermatology and Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Background: Cholinergic urticaria (CholU) is a frequent chronic urticaria disorder with itchy weal and flare-type skin reactions in response to physical exercise or passive warming. A higher frequency of atopy among CholU patients has been reported, but the significance of this observation is unclear.

Objective: To assess the prevalence and relevance of atopy in CholU patients. Read More

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http://dx.doi.org/10.1111/jdv.13765DOI Listing
December 2016
9 Reads

Pharmacologic Therapies in Pulmonology and Allergy.

Med Clin North Am 2016 Jul 20;100(4):851-68. Epub 2016 Apr 20.

Division of Allergy and Infectious Diseases, University of Washington School of Medicine, Seattle, WA 98195, USA; Center for Allergy and Inflammation, UW Medicine at South Lake Union, 750 Republican Street, Box 358061, Seattle, WA 98109-4725, USA.

Conditions such as chronic rhinitis, urticaria, angioedema, and asthma are frequently seen in clinics and hospitals, and there are a core group of medications that are often used to treat these conditions. Knowing the indications, optimal dosing, and side-effect profile of these medications can improve outcomes. Chronic rhinitis due to various causes is one of the most common reasons for primary care physician visits. Read More

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http://dx.doi.org/10.1016/j.mcna.2016.03.010DOI Listing
July 2016
12 Reads

Cholinergic urticaria: More than a simple inducible urticaria.

Australas J Dermatol 2017 Nov 13;58(4):e193-e198. Epub 2016 May 13.

Department of Dermatology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Background: Cholinergic urticaria (ChU) is characterized by small wheals induced by an elevated core temperature. Its pathomechanism and various aspects of its clinical manifestations are still poorly understood. This study aimed to evaluate the spectrum of symptoms and signs of ChU in Korean patients. Read More

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http://dx.doi.org/10.1111/ajd.12496DOI Listing
November 2017
7 Reads

Exercise-induced urticaria, cholinergic urticaria, and Kounis syndrome.

J Pharmacol Pharmacother 2016 Jan-Mar;7(1):48-50

Department of Cardiology, Saint Andrew's State General Hospital, Patras, Greece.

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http://dx.doi.org/10.4103/0976-500X.179355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831493PMC
April 2016
7 Reads

The definition, diagnostic testing, and management of chronic inducible urticarias - The EAACI/GA(2) LEN/EDF/UNEV consensus recommendations 2016 update and revision.

Allergy 2016 06 6;71(6):780-802. Epub 2016 Apr 6.

Department of Dermatology and Allergy, Allergie-Centrum-Charité, Charité - Universitätsmedizin Berlin, Berlin, Germany.

These recommendations for the definition, diagnosis and management of chronic inducible urticaria (CIndU) extend, revise and update our previous consensus report on physical urticarias and cholinergic urticaria (Allergy, 2009). The aim of these recommendations is to improve the diagnosis and management of patients with CIndU. Our recommendations acknowledge the latest changes in our understanding of CIndU, and the available therapeutic options, as well as the development of novel diagnostic tools. Read More

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http://dx.doi.org/10.1111/all.12884DOI Listing
June 2016
36 Reads

Heat urticaria: a revision of published cases with an update on classification and management.

Br J Dermatol 2016 Sep 30;175(3):473-8. Epub 2016 Jun 30.

Department of Medicine, Section of Dermatology, University of Verona, Verona, Italy.

Heat urticaria (HU) is a rare type of physical inducible urticaria, characterized by itchy erythema and well-demarcated weals appearing soon after heat exposure. Most cases occur in female patients aged 20-45 years. Both localized and generalized forms exist, depending on the limitation of the reaction to the skin area directly exposed to the physical stimulus or the involvement of distant sites, respectively. Read More

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http://dx.doi.org/10.1111/bjd.14543DOI Listing
September 2016
9 Reads

Advances in Understanding and Managing Chronic Urticaria.

F1000Res 2016 16;5. Epub 2016 Feb 16.

Division of Clinical Immunology and Allergy, University of Toronto, Toronto, OH, Canada; Gordon Sussman Clinical Research Inc, GSCR, Toronto, ON, Canada.

There have been recent advances in the classification and management of chronic urticaria. The new term chronic spontaneous urticaria (CSU) has replaced chronic idiopathic urticaria and chronic autoimmune urticaria. In addition, chronic inducible urticaria (CINDU) has replaced physical urticaria and includes other forms of inducible urticaria, such as cholinergic and aquagenic urticaria. Read More

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http://dx.doi.org/10.12688/f1000research.7246.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756797PMC
March 2016
17 Reads

Addition of lafutidine can improve disease activity and lead to better quality of life in refractory cholinergic urticaria unresponsive to histamine H1 antagonists.

J Dermatol Sci 2016 May 8;82(2):137-9. Epub 2016 Feb 8.

Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan; Department of Dermatology, Nishi-Kobe Medical Center, 5-7-1 Kojidai, Nishi-ku, Kobe 651-2273, Japan; Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.

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http://dx.doi.org/10.1016/j.jdermsci.2016.02.001DOI Listing
May 2016
10 Reads

Unique case of postural cholinergic urticaria induced by a standing position.

Clin Exp Dermatol 2016 Jun 23;41(4):439-40. Epub 2016 Jan 23.

Department of Dermatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

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http://dx.doi.org/10.1111/ced.12796DOI Listing
June 2016
12 Reads

Cholinergic Urticaria with Anaphylaxis: An Underrecognized Clinical Entity.

J Allergy Clin Immunol Pract 2016 Mar-Apr;4(2):284-91. Epub 2015 Nov 24.

Division of Allergy and Clinical Immunology, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.

Background: Cholinergic urticaria is a form of physical urticaria triggered by high ambient temperature, strenuous physical activity, and strong emotion. These same triggers may cause multisystem reactions that can be life-threatening. A study of patients with cholinergic urticaria with anaphylaxis was undertaken to describe the demographic and clinical features of this form of anaphylaxis. Read More

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http://dx.doi.org/10.1016/j.jaip.2015.09.021DOI Listing
December 2016
8 Reads

A human monoclonal IgE antibody that binds to MGL_1304, a major allergen in human sweat, without activation of mast cells and basophils.

Biochem Biophys Res Commun 2015 Dec 4-11;468(1-2):99-104. Epub 2015 Nov 2.

Department of Dermatology, Institute of Biochemical and Health Sciences, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734-8851, Japan. Electronic address:

MGL_1304, a major allergen in human sweat for patients with atopic dermatitis and/or cholinergic urticaria, is secreted from Malassezia globosa on human skin. The amounts of MGL_1304 and IgE against MGL_1304 are evaluated by the histamine release test using basophils or mast cells sensitized with serum containing IgE against MGL_1304, and enzyme linked sorbent assay (ELISA) using MGL_1304 and anti-MGL_1304 antibodies. Here, we identified a human monoclonal IgE (ABS-IgE) that binds to the high affinity IgE receptor (FcεRI) and MGL_1304 with high affinity (KD = 1. Read More

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http://dx.doi.org/10.1016/j.bbrc.2015.10.154DOI Listing
March 2016
22 Reads

Serum carcinoembryonic antigen (CEA) as a clinical marker in acquired idiopathic generalized anhidrosis: a close correlation between serum CEA level and disease activity.

J Eur Acad Dermatol Venereol 2016 Aug 7;30(8):1379-83. Epub 2015 Oct 7.

Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan.

Background: Hypohidrosis/anhidrosis are congenital or acquired sweating impairments. Among them, acquired idiopathic generalized anhidrosis/hypohidrosis (AIGA) is the most common, and characterized by favourable response to systemic corticosteroid, however, no clinical markers for disease severity or activity have been developed.

Objective: Our aim was to verify the usefulness of serum carcinoembryonic antigen (CEA) level monitoring as a clinical marker for disease activity of AIGA. Read More

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http://dx.doi.org/10.1111/jdv.13390DOI Listing
August 2016
11 Reads