311 results match your criteria Urticaria Cholinergic


Cholinergic Urticaria: Clinical Presentation and Natural History in a Tropical Country.

Biomed Res Int 2020 24;2020:7301652. Epub 2020 May 24.

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Cholinergic urticaria (CholU) is a subset of chronic inducible urticaria characterized by the recurrent pinpoint-sized wheals that are induced by exercising or increasing core body temperature. Currently, the data of CholU in tropical climate is still limited.

Objective: To investigate the clinical features and natural course of CholU in a tropical country. Read More

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http://dx.doi.org/10.1155/2020/7301652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273400PMC

Direct and indirect action modes of acetylcholine in cholinergic urticaria.

Authors:
Yoshiki Tokura

Allergol Int 2020 Jun 18. Epub 2020 Jun 18.

Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan. Electronic address:

Cholinergic urticaria (CholU) manifests small, itchy and/or painful wheals occurring upon perspiration and mechanically involving acetylcholine (Ach). Although a considerable number of studies have been conducted, the pathomechanisms underlying perspiration-associated release of histamine remain to be elucidated. We have proposed that CholU can be categorized into two major subtypes: Ach-indirectly induced, sweat allergic type and Ach-directly induced, depressed sweating type. Read More

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http://dx.doi.org/10.1016/j.alit.2020.05.006DOI Listing

Sensitization against skin resident fungi is associated with atopy in cholinergic urticaria patients.

Clin Transl Allergy 2020 1;10:18. Epub 2020 Jun 1.

Department of Dermatology and Allergy, Allergie-Centrum-Charité/ECARF, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

Background: Cholinergic urticaria (CholU) is a common type of chronic inducible urticaria, characterized by small itchy wheals that appear upon physical exercise or passive warming. , a skin resident fungus, has been identified as an antigen that induces mast cell/basophil degranulation and wheal formation through specific IgE, in Japanese patients with atopic dermatitis and CholU. In this study we aimed in assessing the rate of IgE sensitizations against skin resident fungi in European CholU patients. Read More

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http://dx.doi.org/10.1186/s13601-020-00324-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262772PMC

Omalizumab is effective in patients with chronic spontaneous urticaria plus multiple chronic inducible urticaria.

Eur Ann Allergy Clin Immunol 2020 Jun 4. Epub 2020 Jun 4.

I.M. Sechenov First Moscow State Medical University Sechenov University, Division of Immune mediated skin diseases, Moscow, Russian Federation.

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http://dx.doi.org/10.23822/EurAnnACI.1764-1489.153DOI Listing

Regular sweating activities for the treatment of cholinergic urticaria with or without acquired idiopathic generalized anhidrosis.

Dermatol Ther 2020 May 22:e13647. Epub 2020 May 22.

Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan.

Cholinergic urticaria (CholU) decreases affected individuals' quality of life because they must avoid stimuli including exercise and hot bathing. Although case reports have indicated that regular sweating activities are effective for CholU with hypohidrosis, little evidence is available. This retrospective medical record review examined CholU patients who received any form of treatment at our hospital. Read More

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http://dx.doi.org/10.1111/dth.13647DOI Listing

A visual analogue scale for itch and pain in 23 cases of cholinergic urticaria.

J Eur Acad Dermatol Venereol 2020 Apr 3. Epub 2020 Apr 3.

Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Japan.

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http://dx.doi.org/10.1111/jdv.16410DOI Listing

Urticaria: Collegium Internationale Allergologicum (CIA) Update 2020.

Int Arch Allergy Immunol 2020 30;181(5):321-333. Epub 2020 Mar 30.

Dermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

This update on chronic urticaria (CU) focuses on the prevalence and pathogenesis of chronic spontaneous urticaria (CSU), the expanding spectrum of patient-reported outcome measures (PROMs) for assessing CU disease activity, impact, and control, as well as future treatment options for CU. This update is needed, as several recently reported findings have led to significant advances in these areas. Some of these key discoveries were first presented at past meetings of the Collegium Internationale Allergologicum (CIA). Read More

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http://dx.doi.org/10.1159/000507218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265766PMC
March 2020
2.673 Impact Factor

Real-life treatment of patients with cholinergic urticaria in German-speaking countries.

J Dtsch Dermatol Ges 2019 11;17(11):1141-1147

Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Background: Cholinergic urticaria (CholU) is a frequent type of chronic inducible urticaria. Symptomatic treatment with second-generation antihistamines (sgAH) is recommended by current guidelines as first-line therapy, but little is known about how patients with CholU are treated in real life and how they respond to treatment.

Aim: To assess real-life treatment of CholU in German-speaking countries. Read More

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http://dx.doi.org/10.1111/ddg.13979DOI Listing
November 2019
4 Reads

Cholinergic synovitis: Description of four cases.

Reumatol Clin 2019 Nov 7. Epub 2019 Nov 7.

Servicio de Neurología, Hospital Universitario Ramón y Cajal, Madrid, España.

We present the clinical and ultrasound findings of four patients with moderate synovitis and urticarial skin lesions associated with sports activity in warm environments. We include progress after treatment with hydroxycin. We suggest a causal relationship similar to cholinergic urticaria where the neighbouring synovium responds with effusion that self-limits once the triggering process has been halted. Read More

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http://dx.doi.org/10.1016/j.reuma.2019.08.002DOI Listing
November 2019

Dupilumab use in dermatologic conditions beyond atopic dermatitis - a systematic review.

J Dermatolog Treat 2019 Nov 12:1-10. Epub 2019 Nov 12.

Department of Medicine, Division of Dermatology, University of Arizona, Tucson, AZ, USA.

While dupilumab has emerged as an effective treatment for moderate-to-severe atopic dermatitis (AD) since its approval in 2017, interleukin-4 and 13 blockade has also demonstrated efficacy in off-label chronic dermatologic conditions. To identify chronic dermatologic conditions in which dupilumab has demonstrated efficacy. Thirty-three reports of dupilumab use in non-AD dermatologic conditions were identified through systematic literature review. Read More

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http://dx.doi.org/10.1080/09546634.2019.1689227DOI Listing
November 2019
7 Reads

Cholinergic urticaria with hypohidrosis successfully treated with omalizumab.

J Dermatol 2020 Feb 29;47(2):e47-e48. Epub 2019 Oct 29.

Department of Dermatology, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.

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http://dx.doi.org/10.1111/1346-8138.15141DOI Listing
February 2020

Clinical utility of the basophil activation test in the diagnosis of sweat allergy.

Allergol Int 2020 Apr 12;69(2):261-267. Epub 2019 Oct 12.

Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Japan.

Background: Many patients with atopic dermatitis and cholinergic urticaria display an immediate-type allergy to autologous sweat. Although the histamine release test (HRT) using semi-purified sweat antigen (QR) was available for the detection of immediate sweat allergy, the existence of HRT low responders could not be disregarded. Furthermore, it has not been established whether the results of the HRT are consistent with the autologous sweat skin test (ASwST). Read More

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http://dx.doi.org/10.1016/j.alit.2019.09.003DOI Listing
April 2020
1 Read

A case of cold-induced cholinergic urticaria accompanied by cholinergic urticaria showing a positive ice cube test.

Allergol Int 2020 Jan 23;69(1):150-151. Epub 2019 Aug 23.

Department of Dermatology, Course of Integrated Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.

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http://dx.doi.org/10.1016/j.alit.2019.07.010DOI Listing
January 2020
2 Reads

Effects of Desloratadine Citrate Disodium on Serum Immune Function Indices, Inflammatory Factors and Chemokines in Patients with Chronic Urticaria.

J Coll Physicians Surg Pak 2019 Mar;29(3):214-217

Department of Dermatology, Shaanxi Provincial Hospital of Traditional Chinese Medicine, Xi'an, 710003, China.

Objective: To determine the effects of desloratadine citrate disodium on serum immunological function indices (IgE, C3 and C4), inflammatory factors (IL-4, IL-17 and IL-33), and chemokines (MCP-1, RANTES and Eotaxin) in patients with chronic urticaria.

Study Design: An experimental study.

Place And Duration Of Study: Department of Dermatology, Shaanxi Provincial Hospital of Traditional Chinese Medicine, Xi'an, China, from January 2017 to January 2018. Read More

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http://dx.doi.org/10.29271/jcpsp.2019.03.214DOI Listing
March 2019
9 Reads

Exercise-induce anaphylaxis, food-dependent exercise-induce anaphylaxis, cholinergic urticaria and Kounis syndrome.

Neth J Med 2019 Jan;77(1):38-39

Department of Cardiology, University of Patras Medical School, Rion, Patras, Achaia, Greece.

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January 2019
10 Reads

Efficacy and Safety of Omalizumab (Xolair) for Cholinergic Urticaria in Patients Unresponsive to a Double Dose of Antihistamines: A Randomized Mixed Double-Blind and Open-Label Placebo-Controlled Clinical Trial.

J Allergy Clin Immunol Pract 2019 May - Jun;7(5):1599-1609.e1. Epub 2019 Jan 15.

Department of Allergy and Clinical Immunology, Clinica Universidad de Navarra, Pamplona, Spain; Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain; RETIC de Asma, Reacciones adversas y Alérgicas (ARADYAL), Madrid, Spain. Electronic address:

Background: Cholinergic urticaria (UCOL) is a highly disabling inducible urticaria triggered by an increase in core body temperature.

Objective: To explore the safety and efficacy of omalizumab in controlling UCOL.

Methods: We conducted a multicenter randomized mixed double-blind and open-label (first 4 months blinded followed by 8 months open-label) placebo-controlled clinical trial in 22 patients suffering from UCOL who were unresponsive to a double dose of antihistamines. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.12.025DOI Listing
January 2019
16 Reads

Use of antipsychotic drugs in dermatology.

Clin Dermatol 2018 Nov - Dec;36(6):765-773. Epub 2018 Aug 16.

Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Antipsychotic drugs can be beneficial in dermatology because of their both central nervous system and peripheral effects. All antipsychotic drugs have a central postsynaptic dopamine D2 receptor blocking effect, which underlies their antipsychotic action. The antipsychotic drugs have varying degrees of histamine H1-receptor, cholinergic muscarinic receptor, and α1-adrenergic receptor blocking effects, which can affect cutaneous perception and the autonomic reactivity of the skin and can be potentially beneficial in the management of certain histamine or sympathetically mediated dermatologic manifestations (eg, urticaria, pruritus, hyperhidrosis). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0738081X183017
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http://dx.doi.org/10.1016/j.clindermatol.2018.08.006DOI Listing
March 2019
53 Reads

Omalizumab in Chronic Urticaria: An Italian Survey.

Int Arch Allergy Immunol 2019;178(1):45-49. Epub 2018 Nov 5.

Clinical Dermatology, IRCCS Istituto Ortopedico Galeazzi, Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.

Omalizumab is approved for use in chronic spontaneous urticaria (CSU); however, it is not approved for chronic inducible urticaria (CIndU). The aim of the present study was to assess the effectiveness of omalizumab in treating CSU and CIndU in Italy. This is a multicentre prospective observational real-life study involving patients with severe urticaria capable of undergoing omalizumab therapy. Read More

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https://www.karger.com/Article/FullText/492532
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http://dx.doi.org/10.1159/000492532DOI Listing
April 2019
47 Reads

Drug eruption by antihistamine mistaken for chronic urticaria in a child.

Korean J Pediatr 2019 Feb 30;62(2):75-78. Epub 2018 Oct 30.

Department of Pediatrics, Kangwon National University Hospital, chuncheon, Korea.

Although rare, antihistamines can cause adverse effects, including drug-induced eruptions or anaphylaxis. A 4-year-old child visited the pediatric department of a hospital for skin eruptions after administration of antihistamines, (e.g. Read More

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http://kjp.or.kr/journal/view.php?doi=10.3345/kjp.2018.06695
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http://dx.doi.org/10.3345/kjp.2018.06695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382964PMC
February 2019
52 Reads

Angioedema frequently occurs in cholinergic urticaria.

J Allergy Clin Immunol Pract 2019 Apr 25;7(4):1355-1357.e1. Epub 2018 Oct 25.

Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1016/j.jaip.2018.10.013DOI Listing
April 2019
12 Reads

Real-life treatment of cholinergic urticaria with omalizumab.

J Allergy Clin Immunol 2019 02 9;143(2):788-791.e8. Epub 2018 Oct 9.

Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany.

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http://dx.doi.org/10.1016/j.jaci.2018.08.050DOI Listing
February 2019
54 Reads

Clinico-epidemiological features of chronic urticaria in children: A retrospective analysis of 296 children from a tertiary care institute in Northern India.

Indian J Dermatol Venereol Leprol 2020 Jan-Feb;86(1):50-54

Department of Dermatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Background: Urticaria is a common dermatosis affecting approximately 25% of the population. Childhood chronic urticaria is frequently encountered, however, epidemiologic data on pediatric urticaria are limited.

Aim: The objective of this study was to study the clinico-epidemiological profile of children with chronic urticaria. Read More

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http://dx.doi.org/10.4103/ijdvl.IJDVL_573_17DOI Listing
September 2018
11 Reads
1.325 Impact Factor

Primum non nocere: Anticholinergics and dementia.

Authors:
Dirk M Elston

J Am Acad Dermatol 2018 09;79(3):439-440

Department of Dermatology and Dermatologic Surgery Medical University of South Carolina, Charleston, South Carolina. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01909622183046
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http://dx.doi.org/10.1016/j.jaad.2018.03.016DOI Listing
September 2018
22 Reads

Sweat allergy.

Allergol Int 2018 Oct 31;67(4):435-441. Epub 2018 Jul 31.

Department of Dermatology, Graduate School of Biomedical and Health Sciences, Hiroshima University 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan. Electronic address:

Sweat allergy is defined as a type I hypersensitivity against the contents of sweat, and is specifically observed in patients with atopic dermatitis (AD) and cholinergic urticaria (CholU). The allergic reaction is clinically revealed by positive reactions in the intradermal skin test and the basophil histamine release assay by sweat. A major histamine-releasing antigen in sweat, MGL_1304, has been identified. Read More

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http://dx.doi.org/10.1016/j.alit.2018.07.002DOI Listing
October 2018
20 Reads

How to Approach Chronic Inducible Urticaria.

J Allergy Clin Immunol Pract 2018 Jul - Aug;6(4):1119-1130

Division of Allergy and Immunology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Tex.

Chronic inducible urticaria (CIndU) is a group of chronic urticarias characterized by the appearance of recurrent wheals, recurrent angioedema or both, as a response to specific triggers. CIndU includes both physical (symptomatic dermographism, cold and heat urticaria, delayed pressure urticaria, solar urticaria, and vibratory urticaria) and nonphysical urticarias (cholinergic urticaria, contact and aquagenic urticaria). Here, we review the different forms of CIndU with an emphasis on symptomatic dermographism, cold urticaria, cholinergic urticaria, and delayed pressure urticaria. Read More

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http://dx.doi.org/10.1016/j.jaip.2018.03.007DOI Listing
October 2019
91 Reads

Epidemiology of urticaria including physical urticaria and angioedema in Korea.

Korean J Intern Med 2019 Mar 11;34(2):418-425. Epub 2018 May 11.

Department of Internal Medicine, Kangwon National University Hospital, Chuncheon, Korea.

Background/aims: Despite the high burden and frequency of urticaria, its epidemiology is not well known. We investigated the epidemiology of various type of urticaria in Korea and changes in its annual prevalence over 5 years.

Methods: We used data from the 2010 to 2014 Health Insurance Review and Assessment database, which covers the claims of 97. Read More

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http://dx.doi.org/10.3904/kjim.2017.203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406086PMC
March 2019
14 Reads

Chronic inducible urticaria: A systematic review of treatment options.

J Allergy Clin Immunol 2018 05 10;141(5):1726-1734. Epub 2018 Feb 10.

Department of Dermatology, Venerology and Allergy, Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. Electronic address:

Background: Chronic inducible urticaria (CindU) is a condition characterized by the appearance of recurrent wheals, angioedema, or both as a response to specific and reproducible triggers.

Objective: We sought to systematically assess evidence on the efficacy and safety of treatment options for CindU. Results were used to inform the 2017 update of "The EAACI/GALEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00916749183022
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http://dx.doi.org/10.1016/j.jaci.2018.01.031DOI Listing
May 2018
67 Reads

Development and validation of the Cholinergic Urticaria Quality-of-Life Questionnaire (CholU-QoL).

Clin Exp Allergy 2018 04 28;48(4):433-444. Epub 2018 Feb 28.

Department of Dermatology and Allergy, Urticaria Center of Reference and Excellence (UCARE), Charité-Universitätsmedizin Berlin, Berlin, Germany.

Background: Cholinergic urticaria (CholU), a common form of chronic inducible urticaria, is characterized by itchy weals that occur in response to physical exercise or passive warming. CholU patients frequently exhibit a high burden of disease. As of yet, no specific instrument is available to assess their disease-related quality-of-life (QoL) impairment. Read More

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http://dx.doi.org/10.1111/cea.13102DOI Listing
April 2018
14 Reads

Aquagenic Urticaria: A Perplexing Physical Phenomenon.

Acta Dermatovenerol Croat 2017 Oct;25(3):234-237

Professor Robert A Schwartz MD, MPH, DSc (Hon), FRCP Edin Dermatology Rutgers New Jersey Medical School, 185 South Orange Avenue H-576, Newark, New Jersey 07103;

Aquagenic urticaria (AQ) is a rare physical urticaria induced by contact with water. It may be distinctive clinically, evident as 1-2 mm folliculopapular urticaria, a pattern also characteristic of cholinergic urticaria. AQ has a truncal and upper extremity distribution within 20-30 minutes after contact with water, regardless of its temperature or source. Read More

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October 2017
33 Reads

Authors:

Arerugi 2017;66(9):1185-1186

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http://dx.doi.org/10.15036/arerugi.66.1185DOI Listing
June 2018
17 Reads

Successful treatment of refractory cholinergic urticaria with omalizumab.

Int J Dermatol 2018 01 23;57(1):114. Epub 2017 Oct 23.

Dermatology Department, Royal Free London NHS Foundation Trust, London, UK.

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http://doi.wiley.com/10.1111/ijd.13808
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http://dx.doi.org/10.1111/ijd.13808DOI Listing
January 2018
15 Reads

Cholinergic urticaria patients of different age groups have distinct features.

Clin Exp Allergy 2017 Dec 10;47(12):1609-1614. Epub 2017 Oct 10.

Department of Dermatology and Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Background: Cholinergic urticaria (CholU) is a common skin disease characterized by the development of pinpoint-sized weals and severe itch upon physical exercise. Little is known about the epidemiology of CholU. CholU can occur at any age and has the highest prevalence among young adults. Read More

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http://dx.doi.org/10.1111/cea.13023DOI Listing
December 2017
21 Reads

Omalizumab treatment in patients with chronic inducible urticaria: A systematic review of published evidence.

J Allergy Clin Immunol 2018 02 24;141(2):638-649. Epub 2017 Jul 24.

Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Background: Omalizumab, a recombinant anti-IgE antibody, effectively treats chronic spontaneous urticaria. Evidence is lacking in patients with chronic inducible urticarias (CIndUs), which are frequently H-antihistamine resistant.

Objective: From the current published literature, we aimed to determine the strength of evidence for omalizumab efficacy and safety in the treatment of CIndUs. Read More

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http://dx.doi.org/10.1016/j.jaci.2017.06.032DOI Listing
February 2018
53 Reads

Cholinergic urticaria: Clinicoepidemiological paradigms from a tertiary care center in North India.

Indian J Dermatol Venereol Leprol 2017 Sep-Oct;83(5):599-601

Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_735_16DOI Listing
November 2018
31 Reads

Case of cholinergic urticaria accompanied by anaphylaxis.

J Dermatol 2017 Nov 30;44(11):1291-1294. Epub 2017 Jun 30.

Department of Dermatology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Cholinergic urticaria occasionally occurs in combination with anaphylactic symptoms. However, this has not been widely reported. Herein, we report the case of a 14-year-old Japanese male who was diagnosed with cholinergic urticaria accompanied by anaphylaxis. Read More

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http://dx.doi.org/10.1111/1346-8138.13951DOI Listing
November 2017
53 Reads

Sweat allergy: Extrinsic or intrinsic?

J Dermatol Sci 2017 Jul 9;87(1):3-9. Epub 2017 Mar 9.

Department of Dermatology, Integrated Health Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.

Sweat is an exacerbation factor in atopic dermatitis (AD) in all age groups. A body core temperature elevation with sweating triggers cholinergic urticaria (CholU). We recently reported that AD symptoms are improved by tannic acid-containing spray, which suppresses the basophil histamine release induced by semi-purified sweat antigen in vitro, and by showering, which removes antigens in sweat from the skin surface. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2017.03.002DOI Listing
July 2017
14 Reads

Cholinergic urticaria: epidemiology, physiopathology, new categorization, and management.

Clin Auton Res 2018 02 5;28(1):103-113. Epub 2017 Apr 5.

Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.

Purpose: The aim of this study was to review the evidence on the epidemiology, physiopathology, categorization, and management of cholinergic urticaria. We specifically focused on several subtypes of cholinergic urticaria and investigated the relationship between cholinergic urticaria and idiopathic anhidrosis.

Methods: Using an integrative approach, we reviewed publications addressing the epidemiology, clinical features, diagnostic approach, physiopathology, subtype classification, and therapeutic approach to cholinergic urticaria. Read More

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http://dx.doi.org/10.1007/s10286-017-0418-6DOI Listing
February 2018
36 Reads

Evaluation of the correlation between severity of acquired idiopathic generalized anhidrosis and quality of life scores.

J Dermatol 2017 Jul 22;44(7):747-752. Epub 2017 Mar 22.

Department of Dermatology, Tokyo Medical and Dental University, Tokyo, Japan.

Symptoms of acquired idiopathic generalized anhidrosis (AIGA) include heat retention and/or heat stroke due to the effects of the disorder on the perspiration ability of the whole body under thermal environmental changes or exercise. Additionally, cholinergic urticaria can also occur in these patients. AIGA has a major impact on everyday life. Read More

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http://dx.doi.org/10.1111/1346-8138.13785DOI Listing
July 2017
27 Reads

Serum carcinoembryonic antigen specifically increases among various serum markers of adenocarcinoma in hypohidrosis or conditions related to hypohidrosis.

J Dermatol 2017 Aug 11;44(8):903-908. Epub 2017 Mar 11.

Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan.

Anhidrosis/hypohidrosis are conditions presenting various level of sweating dysfunction. Among them, acquired idiopathic generalized anhidrosis (AIGA) presents inadequate decrease or loss of sweating without apparent neurological and dermatological symptoms except cholinergic urticaria. Recently, serum level of carcinoembryonic antigen (CEA), one of the most well-known tumor markers, has been proposed as a clinical marker reflecting activity of AIGA. Read More

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http://dx.doi.org/10.1111/1346-8138.13828DOI Listing
August 2017
43 Reads

A case of cholinergic urticaria with localized hypohidrosis showing sweat gland eosinophilic infiltration.

Allergol Int 2017 Jul 18;66(3):495-496. Epub 2017 Jan 18.

Department of Dermatology, Tokyo Medical University, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.alit.2016.11.007DOI Listing
July 2017
44 Reads

Cross-reactive LTP sensitization in food-dependent exercise-induced urticaria/anaphylaxis: a pilot study of a component-resolved and in vitro depletion approach.

Clin Transl Allergy 2016 22;6:46. Epub 2016 Dec 22.

Serviço de Imunoalergologia, Centro Hospitalar São João, Porto, Portugal ; Laboratory of Immunology, Basic and Clinical Immunology Unit, Faculty of Medicine, Porto University, Porto, Portugal ; Unidade de Imunoalergologia, Unidade Local de Saúde do Alto Minho, Viana Do Castelo, Portugal ; Department of Clinical Pathology, Centro Hospitalar São João, Porto, Portugal ; CINTESIS and Biostatistics and Medical Informatics, Faculty of Medicine, University of Porto, Porto, Portugal.

Background: Challenge tests for food-dependent exercise-induced anaphylaxis (FDEIA) carry some risk and have a high rate of false negatives. Our aim was to explore the usefulness of an in vitro immunodepletion assay and an allergen microarray test in the identification of IgE-mediated cross-reactive food allergens in patients with suspected FDEIA or food-dependent exercise-induced urticaria and panallergen sensitization.

Methods: Three patients with a history of food dependent exercise induced urticaria/anaphylaxis and food panallergen sensitization in whom a food-exercise challenge was not feasible were selected: a 25-year-old man with cholinergic urticaria who experienced generalized urticaria and angioedema during a soccer match after drinking a peach-based soft drink; a 19-year-old woman with allergic rhinitis and controlled asthma who experienced anaphylactic shock while playing soccer, having eaten walnuts in the previous 90 min; and a 57-year-old man with baker's asthma who experienced four episodes of anaphylaxis during exercise after ingesting wheat-containing food. Read More

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http://dx.doi.org/10.1186/s13601-016-0136-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5180400PMC
December 2016
90 Reads

Pure Cold-Induced Cholinergic Urticaria in a Pediatric Patient.

Case Reports Immunol 2016 29;2016:7425601. Epub 2016 Nov 29.

Allergy/Immunology Associates, Inc., Mayfield Heights, OH, USA.

Cold urticaria and cholinergic urticaria are two distinct entities. The presentation of exclusive cold-induced cholinergic urticaria is very rare. The patient described herein had experienced urticaria in the exclusive setting of exercising in a cold environment. Read More

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http://dx.doi.org/10.1155/2016/7425601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153475PMC
November 2016
34 Reads

Clinical and etiologic evaluation of the children with chronic urticaria.

Allergy Asthma Proc 2016 11;37(6):450-457

Pediatric Allergy and Immunology, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey.

Background: Chronic urticaria (CU) is a skin disorder defined as daily or almost daily exhibition of pruritic and transient wheals that last for 6 weeks. CU is divided into two subtypes: chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU).

Objectives: To evaluate the clinical features, possible causes, associated findings, and laboratory results of different subtypes of CU in children according to a new classification. Read More

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http://dx.doi.org/10.2500/aap.2016.37.4010DOI Listing
November 2016
46 Reads

Clinical characteristics in cholinergic urticaria with palpebral angioedema: Report of 15 cases.

J Dermatol Sci 2017 Feb 11;85(2):135-137. Epub 2016 Nov 11.

Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.

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http://dx.doi.org/10.1016/j.jdermsci.2016.11.001DOI Listing
February 2017
47 Reads

Omalizumab in the Treatment of Chronic Inducible Urticaria.

Actas Dermosifiliogr 2017 Jun 5;108(5):423-431. Epub 2016 Oct 5.

Servicio de Dermatología, Hospital Universitario de La Princesa, Madrid, España.

Omalizumab is a recombinant humanized monoclonal antibody that inhibits immunoglobulin E. It has been approved for the treatment of severe asthma and chronic spontaneous urticaria refractory to other treatments. Its use in the management of chronic inducible urticaria (a type triggered by certain stimuli) is still considered off-label, although this use has been discussed in some consensus papers. Read More

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http://dx.doi.org/10.1016/j.ad.2016.07.018DOI Listing
June 2017
42 Reads

Inducible urticaria: Case series and literature review.

Biomedica 2016 Mar 3;36(1):10-21. Epub 2016 Mar 3.

Grupo de Alergología Clínica y Experimental (GACE), IPS Universitaria, Universidad de Antioquia, Medellín, Colombia.

Inducible urticaria is a heterogeneous group of skin disorders characterized by the appearance of wheals, pruritus and/or angioedema, sometimes accompanied by systemic symptoms caused by innocuous stimuli (cold, heat, pressure, etc.). This group of disorders compromises people's quality of life and most of the literature in this regard comes from case reports and case series since its epidemiology has been poorly studied and some cases are very rare. Read More

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http://dx.doi.org/10.7705/biomedica.v36i1.2678DOI Listing
March 2016
31 Reads

Diagnostic utility of challenge procedures for physical urticaria/angioedema syndromes: a systematic review.

Curr Opin Allergy Clin Immunol 2016 10;16(5):511-5

aDepartment of Internal MedicinebDepartment of Allergy and Clinical Immunology, Respiratory Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Purpose Of Review: Physical urticaria/angioedema syndromes (PUAs) are commonly encountered. They are identified by a history of physical factors provoking cutaneous symptoms, and confirmed by provocation testing. Recent guidelines have recommended use of challenge procedures for diagnosis; however, their positive/negative likelihood ratios have not been established. Read More

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http://dx.doi.org/10.1097/ACI.0000000000000298DOI Listing
October 2016
43 Reads

Sweat Allergy.

Curr Probl Dermatol 2016 30;51:101-8. Epub 2016 Aug 30.

For many years, sweat has been recognized as an exacerbation factor in all age groups of atopic dermatitis (AD) and a trigger of cholinergic urticaria (CholU). Recently, we reported the improvement of AD symptoms by spray with tannic acid, which suppresses basophil histamine release by semipurified sweat antigens in vitro, and showering that removes antigens in sweat from the skin surface. We finally identified MGL_1304 secreted by Malassezia globosa as a major histamine-releasing antigen in human sweat. Read More

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http://dx.doi.org/10.1159/000446788DOI Listing
April 2017
36 Reads

New Etiology of Cholinergic Urticaria.

Authors:
Yoshiki Tokura

Curr Probl Dermatol 2016 30;51:94-100. Epub 2016 Aug 30.

Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Cholinergic urticaria (CholU) is characterized by pinpoint-sized, highly pruritic wheals occurring upon sweating. Both direct and indirect theories in the interaction of acetylcholine (ACh) with mast cells have been put forward in the sweating-associated histamine release from mast cells. In the mechanism of indirect involvement of ACh, patients are hypersensitive to sweat antigen(s) and develop wheals in response to sweat substances leaking from the syringeal ducts to the dermis, possibly by obstruction of the ducts. Read More

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http://dx.doi.org/10.1159/000446787DOI Listing
April 2017
30 Reads