2,371 results match your criteria Urticaria Acute


The first case of tegoprazan-induced urticaria.

J Clin Pharm Ther 2020 Jun 29. Epub 2020 Jun 29.

Division of Allergy, Asthma, and Clinical Immunology, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.

What Is Known And Objective: Tegoprazan induces adverse drug reactions during clinical trials; however, tegoprazan-induced urticaria has not been reported. Here, we describe the first case of this.

Case Description: A 55-year-old woman presented with acute urticaria with pruritus after taking the gastro-oesophageal reflux disease medication, tegoprazan. Read More

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http://dx.doi.org/10.1111/jcpt.13150DOI Listing

Recurrent Type III Kounis Syndrome: Will Anti-Immunoglobulin E Drug Be Another Option?

Can J Cardiol 2020 Jun 10;36(6):966.e5-966.e6. Epub 2019 Dec 10.

Division of Cardiology, Tianjin 1st Central Hospital, Tianjin, China. Electronic address:

Kounis syndrome was recognized as the concurrence of acute cardiovascular events with hypersensitivity reactions. We report a case of Kounis syndrome type III (coronary thrombosis) variant in a 48-year-old man who had experienced recurrent acute myocardial infarctions after scallion-induced hypersensitivity reactions. After appropriate antithrombotic, antihistamine, and reperfusion strategies, the patient was found to have elevated levels of immunoglobulin E and chronic urticaria. Read More

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http://dx.doi.org/10.1016/j.cjca.2019.12.007DOI Listing

Considerations on Biologicals for Patients with allergic disease in times of the COVID-19 pandemic: an EAACI Statement.

Allergy 2020 Jun 5. Epub 2020 Jun 5.

Translational Medicine Program, Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, Toronto, Ontario, Canada.

The outbreak of the SARS-CoV-2-induced Coronavirus Disease 2019 (COVID-19) pandemic re-shaped doctor-patient interaction and challenged capacities of healthcare systems. It created many issues around the optimal and safest way to treat complex patients with severe allergic disease. A significant numberof the patients are on treatment with biologicals and clinicians face the challenge to provide optimal care during the pandemic. Read More

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http://dx.doi.org/10.1111/all.14407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300800PMC

Urticaria, Angioedema, and Anaphylaxis.

Pediatr Rev 2020 Jun;41(6):283-292

University of Rochester, Rochester, NY.

Urticaria and, to a lesser extent, angioedema are common occurrences in the pediatric population. There are multiple causes of acute and chronic urticaria and angioedema. Most causes are benign, although they can be worrisome for patients and their parents. Read More

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http://dx.doi.org/10.1542/pir.2019-0056DOI Listing

Flame Figures in Linear Immunoglobulin A Bullous Dermatosis Secondary to Parvovirus B19 Infection.

Am J Dermatopathol 2020 May 28. Epub 2020 May 28.

Departments of Dermatology, and.

Flame figures represent a characteristic but nondiagnostic histological finding in eosinophilic dermatoses. Some bullous autoimmune diseases with a predominant eosinophilic infiltrate, such as bullous pemphigoid, pemphigoid gestationis, and pemphigus vegetans, may show them. However, it is rare to find them in predominant neutrophilic bullous dermatoses such as linear immunoglobulin A. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001690DOI Listing

Gastrointestinal involvement of primary skin diseases.

J Eur Acad Dermatol Venereol 2020 May 26. Epub 2020 May 26.

Center for Research & Development, Kaohsiung Municipal Siaogang Hospital, Kaohsiung, Taiwan.

Less is known about gastrointestinal (GI) involvement of primary skin diseases due to the difference in embryology, histology, microbiology and physiology between integument and alimentary tract. Oesophagus, following the oropharyngeal mucosa, is the most common GI segment affected by primary skin diseases, especially by eosinophilic oesophagitis, lichen planus and autoimmune bullous dermatoses like pemphigus vulgaris, mucosal membrane pemphigoid and epidermolysis bullosa acquisita. Eosinophilic oesophagitis is an emerging chronic atopic disease with oesophageal dysfunction as the typical presentation, and oesophageal narrowing, rings and stricture as late complications. Read More

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http://dx.doi.org/10.1111/jdv.16676DOI Listing

A Phased Approach to Resuming Suspended Allergy/Immunology Clinical Services.

J Allergy Clin Immunol Pract 2020 May 22. Epub 2020 May 22.

Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colo. Electronic address:

In early 2020, the first US and Canadian cases of the novel severe acute respiratory syndrome coronavirus 2 infection were detected. In the ensuing months, there has been rapid spread of the infection. In March 2020, in response to the virus, state/provincial and local governments instituted shelter-in-place orders, and nonessential ambulatory care was significantly curtailed, including allergy/immunology services. Read More

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http://dx.doi.org/10.1016/j.jaip.2020.05.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242939PMC

SARS-Coronavirus-2 and acute urticaria.

Int J Dermatol 2020 Jul 22;59(7):867-868. Epub 2020 May 22.

Hospital Universitario 12 de Octubre, Madrid, Spain.

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http://dx.doi.org/10.1111/ijd.14950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280648PMC

Follow-up of skin lesions during the evolution of COVID-19: a case report.

Arch Dermatol Res 2020 May 14. Epub 2020 May 14.

Medical Faculty of Recife, Centro de Ciências Médicas, Federal University of Pernambuco, Av. da Engenharia, 531-611 - Cidade Universitária, Recife, 50730-120, PE, Brazil.

The disease caused by the new coronavirus (COVID-19) has many systemic manifestations affecting the upper airways, lungs, gastrointestinal tract and inducing hematological repercussions. With the evolution of the pandemic, skin lesions were observed. However, there is little information about the evolution of the lesions at this moment. Read More

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http://dx.doi.org/10.1007/s00403-020-02091-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221337PMC

A case of COVID-19 pneumonia presenting with acute urticaria.

Dermatol Ther 2020 May 13. Epub 2020 May 13.

University of Health Sciences Atatürk Chest Diseases and Chest Surgery Education and Research Hospital, Division of Immunology and Allergy, Department of Chest Diseases, Ankara, Turkey.

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http://dx.doi.org/10.1111/dth.13575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272955PMC

An Atypical Presentation of Epstein-Barr Virus Associated Infectious Mononucleosis Mistaken for Pyelonephritis.

Cureus 2020 Apr 7;12(4):e7583. Epub 2020 Apr 7.

Nephrology, Raymond G. Murphy Veterans Affairs Medical Center, Albuquerque, USA.

Infectious mononucleosis, a syndrome characterized by the triad of pharyngitis, fever, and lymphadenopathy, is caused in the majority of cases by Epstein-Barr virus and usually presents in adolescents and young adults. The disease is for the most part self-limited with full recovery; however, life-threatening complications can occur. Manifestations of Epstein-Barr virus associated infectious mononucleosis can be variable and at times atypical, leading to a delay in diagnosis and consequently unnecessary tests and treatment. Read More

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http://dx.doi.org/10.7759/cureus.7583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212761PMC

Urticaria: recommendations from the Italian Society of Allergology, Asthma and Clinical Immunology and the Italian Society of Allergological, Occupational and Environmental Dermatology.

Clin Mol Allergy 2020 6;18. Epub 2020 May 6.

5Section of Dermatology, Department of Medicine, University of Perugia, Perugia, Italy.

Background: Urticaria is a disorder affecting skin and mucosal tissues characterized by the occurrence of wheals, angioedema or both, the latter defining the urticaria-angioedema syndrome. It is estimated that 12-22% of the general population has suffered at least one subtype of urticaria during life, but only a small percentage (estimated at 7.6-16%) has acute urticaria, because it is usually self-limited and resolves spontaneously without requiring medical attention. Read More

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http://dx.doi.org/10.1186/s12948-020-00123-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201804PMC

Cutaneous signs in COVID-19 patients: A review.

Dermatol Ther 2020 May 10:e13549. Epub 2020 May 10.

Department of Dermatology and Venereology, University of Rome G. Marconi, Rome, Italy.

Coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) primarily affects the epithelium of the airways. With the increasing involvement of dermatologist in management of this crisis, cutaneous symptoms gained more and more attention. In this review, we will describe cutaneous symptoms of patients of all ages in association with COVID-19. Read More

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http://dx.doi.org/10.1111/dth.13549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273098PMC

Acute urticaria with angioedema in the setting of coronavirus disease 2019.

J Allergy Clin Immunol Pract 2020 May 5. Epub 2020 May 5.

Allergology Department, Quironsalud Hospital, Barcelona, Spain.

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http://dx.doi.org/10.1016/j.jaip.2020.04.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199726PMC

Cutaneous manifestations of COVID-19: Report of three cases and a review of literature.

J Dermatol Sci 2020 May 29;98(2):75-81. Epub 2020 Apr 29.

Dermatology Department, Emek Medical Center, Israel; Bruce Rappaport Faculty of Medicine, Technion - Institute of Technology, Israel; Department of Medicine, University of Toronto, Toronto, Ontario, Canada. Electronic address:

Background: Various cutaneous manifestations have been observed in patients with COVID-19 infection. However, overall similarities in the clinical presentation of these dermatological manifestations have not yet been summarized.

Objective: This review aims to provide an overview of various cutaneous manifestations in patients with COVID-19 through three case reports and a literature review. Read More

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http://dx.doi.org/10.1016/j.jdermsci.2020.04.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189855PMC
May 2020
3.419 Impact Factor

Pediatric urticaria in the Emergency Department: epidemiological characteristics and predictive factors for its persistence in children.

Eur Ann Allergy Clin Immunol 2020 05 6. Epub 2020 May 6.

Department of Pediatrics, Pugliese-Ciaccio Hospital of Catanzaro, Italy.

Summary: Acute urticaria (AU) in children is a common clinical manifestation responsible for admission to the emergency department (ED). We aimed to analyze the epidemiological characteristics of AU in children and to identify predictors of both severity and progression. We evaluated 314 children admitted to the ED with a diagnosis of AU. Read More

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http://dx.doi.org/10.23822/EurAnnACI.1764-1489.148DOI Listing

Caplacizumab for treatment of thrombotic thrombocytopenic purpura in a patient with anaphylaxis to fresh-frozen plasma.

Transfusion 2020 May 1. Epub 2020 May 1.

Diagnostic Laboratories, Versiti Blood Center of Wisconsin, Milwaukee, Wisconsin, USA.

Background: Plasma exchange with plasma replacement has been the mainstay for the treatment of thrombotic thrombocytopenic purpura (TTP) for several decades. Recently an anti-von Willebrand factor (VWF) medication, caplacizumab, has been approved for treatment of TTP when used with plasma exchange. We report a patient with immune-mediated TTP that had an anaphylactic reaction to plasma who was then given caplacizumab daily for 1 week without further plasma exchange therapy with a good clinical and laboratory response. Read More

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http://dx.doi.org/10.1111/trf.15823DOI Listing

[Urticaria in children].

Rev Fr Allergol (2009) 2020 Apr 27. Epub 2020 Apr 27.

Unité de dermatologie pédiatrique, hôpital Pellegrin-Enfants, place Amélie-Raba-Léon, 33076 Bordeaux, France.

The cumulative incidence of urticaria in children is close to 10%. Two forms are described: the superficial form and the deep form, or angioedema. In young children aged under 3 years, urticaria is commonly annular and ecchymotic, and is mistaken for erythema multiforme or acute hemorrhagic edema. Read More

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http://dx.doi.org/10.1016/j.reval.2020.02.239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185918PMC

Cutaneous manifestations in COVID-19: Lessons learned from current evidence.

J Am Acad Dermatol 2020 Jul 24;83(1):e57-e60. Epub 2020 Apr 24.

Division of Dermatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

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http://dx.doi.org/10.1016/j.jaad.2020.04.094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194618PMC

Vascular skin symptoms in COVID-19: a french observational study.

J Eur Acad Dermatol Venereol 2020 Apr 27. Epub 2020 Apr 27.

Dermatology Department, Paris University, Saint-Louis Hospital, Paris, France.

Coronavirus 19 (COVID-19) was declared as a pandemic viral infection by the World Health organization on March 11 2020. Usual clinical manifestations of COVID-19 infection include fever, fatigue, myalgia, headache, diarrhea, dry cough, dyspnea that may lead to acute respiratory distress syndrome and death (1). Skin symptoms of COVID-19 have been poorly described but may include erythematous rash, urticaria and chicken pox like lesions (2-7). Read More

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http://dx.doi.org/10.1111/jdv.16544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267662PMC

Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome.

Elife 2020 04 27;9. Epub 2020 Apr 27.

Intensive Care, Radboudumc Center for Infectious Diseases (RCI), Radboudumc, Nijmegen, Netherlands.

COVID-19 patients can present with pulmonary edema early in disease. We propose that this is due to a local vascular problem because of activation of bradykinin 1 receptor (B1R) and B2R on endothelial cells in the lungs. SARS-CoV-2 enters the cell via ACE2 that next to its role in RAAS is needed to inactivate des-Arg9 bradykinin, the potent ligand of the B1R. Read More

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http://dx.doi.org/10.7554/eLife.57555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213974PMC

Acute urticaria with pyrexia as the first manifestations of a COVID-19 infection.

J Eur Acad Dermatol Venereol 2020 Apr 24. Epub 2020 Apr 24.

Dermatology Department, Ambroise Paré University Hospital Center, Mons, Belgium.

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http://dx.doi.org/10.1111/jdv.16523DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264566PMC

Intravenous Cetirizine (Quzyttir) for Acute Urticaria.

Authors:

Med Lett Drugs Ther 2020 Apr;62(1595):55-56

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Clinical Manifestations and Causes of Anaphylaxis. Analysis of 382 Cases from the Anaphylaxis Registry in West Pomerania Province in Poland.

Int J Environ Res Public Health 2020 Apr 17;17(8). Epub 2020 Apr 17.

Clinical Allergology Department, Pomeranian Medical University (PMU) in Szczecin, Powstańców Wlkp 72, 70-111 Szczecin, Poland.

Anaphylaxis is most commonly defined as an acute, severe, potentially life-threatening systemic hypersensitivity reaction. Current expert consensus has defined anaphylaxis as a serious reaction that is rapid in onset and can be fatal, and is a severe, potentially life-threatening systemic hypersensitivity reaction that is still rarely diagnosed. For safety reasons, patients should visit an allergologist to identify potential causes of this reaction. Read More

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http://dx.doi.org/10.3390/ijerph17082787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215547PMC

Hypothyroidism-associated angioedema.

Proc (Bayl Univ Med Cent) 2020 Apr 12;33(2):254-255. Epub 2020 Feb 12.

Department of Internal Medicine, Oklahoma State University Center for Health SciencesTulsaOklahoma.

We present a 41-year-old woman with hypothyroidism who presented to the emergency department with acute onset of angioedema and profound hypothyroidism. She required complex airway management and medical treatment before being discharged home 10 days later. This may be the first case of hypothyroidism-induced angioedema that was not associated with chronic urticaria or hives. Read More

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http://dx.doi.org/10.1080/08998280.2020.1724847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7156002PMC

Urticaria and Angioedema Across the Ages.

J Allergy Clin Immunol Pract 2020 Jun 13;8(6):1866-1874. Epub 2020 Apr 13.

Dermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Berlin, Germany. Electronic address:

Chronic urticaria (CU) and angioedema can occur at any age. Although most CU with or without angioedema occurs in adults, it can also present in children or the elderly and can complicate pregnancy and breast-feeding. The presentations of CU and angioedema are different in children, middle-aged adults, and older patients as are the differential diagnoses. Read More

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http://dx.doi.org/10.1016/j.jaip.2020.03.030DOI Listing

Urticarial eruption in COVID-19 infection.

J Eur Acad Dermatol Venereol 2020 Jun;34(6):e244-e245

Department of Dermatology, CHR Orléans, Orléans, France.

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http://dx.doi.org/10.1111/jdv.16472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262133PMC

Stress-induced Interaction of Skin Immune Cells, Hormones, and Neurotransmitters.

Clin Ther 2020 May 7;42(5):757-770. Epub 2020 Apr 7.

Department of Dermatovenereology, University Hospital Center Sestre Milosrdnice, Zagreb, Croatia. Electronic address:

Purpose: Although scientific articles mention the impact of psychological stress on skin diseases, few review the latest research on factors involved in this correlation. The skin actively responds to psychological stress, with involvement of skin immune cells, hormones, neurotransmitters. Skin immune cells actively regulate tissue inflammation with their proinflammatory and anti-inflammatory effects. Read More

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http://dx.doi.org/10.1016/j.clinthera.2020.03.008DOI Listing

Generalized pustular figurate erythema: A newly delineated severe cutaneous drug reaction linked with hydroxychloroquine.

Dermatol Ther 2020 05 16;33(3):e13380. Epub 2020 Apr 16.

Rutgers New Jersey Medical School, Newark, New Jersey, USA.

A severe cutaneous drug reaction resembling acute generalized exanthematous pustulosis resulting from ingestion of hydroxychloroquine has been documented. It is distinguishable by its longer incubation period, more varied morphology with initially urticarial and later targetoid and arcuate plaques, recalcitrance to therapy and longer duration. Given the anticipated surge in the use of hydroxychloroquine due to its reported benefits in those with coronavirus disease 2019, specific recognition of this entity is pivotal. Read More

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http://dx.doi.org/10.1111/dth.13380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235477PMC

Urticaria and silent parasitism by Ascaridoidea: Component-resolved diagnosis reinforces the significance of this association.

PLoS Negl Trop Dis 2020 04 3;14(4):e0008177. Epub 2020 Apr 3.

Laboratory of Parasitology and Allergy, Research Center Lascaray, Department of Immunology, Microbiology and Parasitology, University of the Basque Country, Faculty of Pharmacy, Paseo de la Universidad, Vitoria, Spain.

Urticaria remains a major problem in terms of aetiology, investigation, and management, and although parasitic diseases are considered potential causes, the absence of a consistent link between parasitic infections and skin allergy symptoms leads to the need for a deeper study of parameters that support this association. The objectives of this study were to analyse a possible relationship between parasitism by Ascarididae (Toxocara canis and Anisakis simplex) and the clinical expression of urticaria and to identify possible parasitic molecular markers for improving the diagnosis of unknown urticaria aetiology. The prevalence of Toxocara and Anisakis infestations was evaluated by measuring the levels of specific IgG (sIgG) and IgE (sIgE) antibodies against crude extracts and isolated components from whole larvae of Anisakis simplex (Ani s 1, Ani s 3 and Ani s 7) and Toxocara canis (TES-120, TES-70, TES-32 and TES-26) using immunologic and molecular diagnostic methods. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170265PMC

Skin and Mucous Membrane Eruptions Associated with Chlamydophila Pneumoniae Respiratory Infections: Literature Review.

Dermatology 2020 Mar 27:1-6. Epub 2020 Mar 27.

Pediatric Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Background: Mycoplasma pneumoniae pneumonia is sometimes associated with skin or mucous membrane eruptions. Available reviews do not address the association of Chlamydophila pneumoniae pneumonia with skin eruptions. We therefore conducted a systematic review of the literature addressing this issue. Read More

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http://dx.doi.org/10.1159/000506460DOI Listing

The rash that presents as a red swollen face.

Clin Dermatol 2020 Jan - Feb;38(1):63-78. Epub 2019 Oct 23.

Dermatology Department, Coimbra University Hospital, Coimbra, Portugal; Clinic of Dermatology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal. Electronic address:

A red swollen face can be a skin sign of a potentially life-threatening condition. We present in detail the main clinical presentations, diagnostic tests, and management of some of the most severe conditions that can frequently present as a red and swollen face: acute or recurrent angioedema, mast cell-driven or bradykinin-mediated angioedema, nonhereditary and hereditary angioedema, allergic or photoallergic facial contact dermatitis, contact urticaria, severe adverse drug reactions (particularly drug reaction with eosinophilia and systemic symptoms [DRESS]), skin infections (erysipelas, cellulitis, necrotizing fasciitis), and autoimmune diseases (dermatomyositis). There are many other conditions that also have to be considered in the differential diagnosis of a red swollen face. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2019.10.017DOI Listing
October 2019

Aleukemia cutis: Clinicopathological and molecular investigation of two cases.

J Cutan Pathol 2020 Mar 20. Epub 2020 Mar 20.

Department of Pathology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.

We describe two cases of acute myeloid leukemia (AML) who presented with cutaneous manifestations. Leukemia cutis (LC) is the cutaneous presentation of any type of leukemia and occurs in 10% to 15% of patients with AML, but cutaneous infiltration of AML rarely precedes the involvement of the bone marrow or peripheral blood and is called as "aleukemia cutis." Our first case presented with facial skin thickening, a manifestation which is known as lionization and his initial clinical diagnosis was nonspecific allergic reaction. Read More

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http://dx.doi.org/10.1111/cup.13690DOI Listing
March 2020
1.560 Impact Factor

Oral mite anaphylaxis after ingestion of Korean pancake.

Respir Med Case Rep 2020 4;30:101026. Epub 2020 Mar 4.

Department of Respiratory Medicine, Tokyo Medical University Ibaraki Medical Center, 3-20-1 Chuou, Ami, Inashiki, Ibaraki, 300-0395, Japan.

Background: Oral mite anaphylaxis (OMA) is a syndrome characterized by severe allergic manifestations occurring in atopic patients shortly after the intake of foods made with mite-contaminated wheat flour. A history of atopic disease has been identified as one of risk factors for the development of OMA. This is the report that OMA was induced by the ingestion of Korean pancake prepared with commercial mixed wheat flour contaminated with mites. Read More

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http://dx.doi.org/10.1016/j.rmcr.2020.101026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068120PMC

Chronic urticaria and thyroid pathology.

World Allergy Organ J 2020 Mar 6;13(3):100101. Epub 2020 Mar 6.

Centro Regional de Alergia e Inmunología Clinica, Hospital Universitario "Dr. José Eleuterio González", Ave. Gonzalitos y Madero, s/n, Colonia Mitras Centro, CP. 64460, Monterrey, Nuevo Leon, Mexico.

Urticaria is defined as the sudden appearance of erythematous, itchy wheals of variable size, with or without angioedema (AE) (swelling of the deeper layers of the skin). Its classification depends on time course of symptoms and the presence of eliciting factors. When it lasts less than 6 weeks it is classified as acute urticaria (AU), and if the symptoms persist for more than 6 weeks, it is classified as chronic urticaria (CU). Read More

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http://dx.doi.org/10.1016/j.waojou.2020.100101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063156PMC

An Unusual Case of Acquired Angioedema and Monoclonal Gammopathy of Renal Significance in a Middle-Aged Caucasian Female.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620912096

Lynchburg Nephrology Physicians, Lynchburg, VA, USA.

Acquired angioedema due to deficiency of C1 esterase inhibitor is also called acquired angioedema and is abbreviated as C1INH-AAE. It is a rare syndrome of recurrent episodes of angioedema, without urticaria, and in some patients, it is associated with B-cell lymphoproliferative disorders. Kidney involvement is rare in this condition. Read More

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http://dx.doi.org/10.1177/2324709620912096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074490PMC

A randomized controlled trial of adding intravenous corticosteroids to H1 antihistamines in patients with acute urticaria.

Am J Emerg Med 2020 Feb 19. Epub 2020 Feb 19.

Immunology Unit, Department of Microbiology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok 10330, Thailand. Electronic address:

Background: Acute urticaria is a common dermatological condition in emergency departments (EDs). The main therapy involves controlling pruritus with antihistamines. Although guidelines have promoted the use of corticosteroids in addition to H1 antihistamines, well-designed clinical trials evaluating this approach are scarce. Read More

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http://dx.doi.org/10.1016/j.ajem.2020.02.025DOI Listing
February 2020

Hypersensitivity reactions to proton-pump inhibitors: Clinical presentation, diagnosis, and management.

Allergy Asthma Proc 2020 03;41(2):e37-e44

Division of Allergy and Immunology, Department of Chest Diseases, Ankara University School of Medicine, Ankara, Turkey.

Proton-pump inhibitors (PPI) are one of the most commonly prescribed drugs, and they are generally well tolerated. However, several immediate and delayed hypersensitivity reactions due to PPIs have been reported. To review the clinical characteristics and management of immune-mediated immediate and delayed hypersensitivity reactions to PPIs. Read More

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http://dx.doi.org/10.2500/aap.2020.41.190033DOI Listing

Update on bradykinin-mediated angioedema in 2020.

Therapie 2020 Apr 13;75(2):195-205. Epub 2020 Feb 13.

Centre de référence national des angioedèmes (CREAK), centre hospitalier universitaire Grenoble-Alpes, 38000 Grenoble, France.

Bradykinin-mediated angioedema is a rare disease, due to vasodilation and increased vascular permeability resulting from bradykinin. This kind of angioedema affects abdominal and/or upper airways. It differs clinically from histamine-mediated angioedema by the absence of urticaria or skin rash. Read More

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http://dx.doi.org/10.1016/j.therap.2020.02.011DOI Listing

Prevalence of allergen sensitization among 1,091 patients with urticaria.

Exp Ther Med 2020 Mar 23;19(3):1908-1914. Epub 2019 Dec 23.

Clinical Laboratory, Key Clinical Laboratory of Henan Province, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.

The etiology of urticaria is heterogeneous and allergic responses may be involved in it. The aim of the present study was to investigate the prevalence and distribution of sensitivity to inhaled and food allergens among patients with urticaria in Henan province (China). The levels of specific immunoglobulin E (sIgE) were detected using the AllergyScreen test and a total of 524/1,091 cases (48. Read More

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http://dx.doi.org/10.3892/etm.2019.8367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027159PMC

Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China.

Allergy 2020 Feb 19. Epub 2020 Feb 19.

Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Background: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been widely spread. We aim to investigate the clinical characteristic and allergy status of patients infected with SARS-CoV-2.

Methods: Electronic medical records including demographics, clinical manifestation, comorbidities, laboratory data, and radiological materials of 140 hospitalized COVID-19 patients, with confirmed result of SARS-CoV-2 viral infection, were extracted and analyzed. Read More

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http://dx.doi.org/10.1111/all.14238DOI Listing
February 2020

Combinatorial Assessment of Serum Inflammation Reactants in Patients with Acute Urticaria Accompanied by Systemic Symptoms.

Indian J Dermatol 2020 Jan-Feb;65(1):67-68

Department of Dermatology, The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China.

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http://dx.doi.org/10.4103/ijd.IJD_286_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986129PMC
February 2020

Rationale for the autologous serum skin test in acute versus chronic urticaria.

Postepy Dermatol Alergol 2019 Dec 30;36(6):703-706. Epub 2019 Dec 30.

Department of Pulmonary Diseases, Division of Immunology and Allergy, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey.

Introduction: Autologous serum skin test (ASST) is a rapid, clinical test to detect functional autoantibodies in patients with chronic spontaneous urticaria (CSU), but the rationale for its use in acute urticaria (AU) is unknown.

Aim: To evaluate the efficacy of ASST among patients with AU or CSU.

Material And Methods: Treatment-naïve adult (age ≥ 18 years) patients with a diagnosis of AU (< 6 weeks' duration) and CSU were enrolled prospectively in a cross-sectional study. Read More

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http://dx.doi.org/10.5114/ada.2019.91421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986284PMC
December 2019

Acute urticaria in the pediatric emergency department: Management and possible triggers.

Ann Allergy Asthma Immunol 2020 04 22;124(4):396-397. Epub 2020 Jan 22.

Department of Allergy, Hospital Universitario La Paz, Madrid, Spain; Department of Allergy, Hospital La Paz Institute for Health Research (IDIPAZ), Madrid, Spain.

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http://dx.doi.org/10.1016/j.anai.2020.01.007DOI Listing

[Nephropathy associated with hypocomplementemic urticarial vasculitis: A case report and literature review].

Nephrol Ther 2020 Mar 9;16(2):124-135. Epub 2020 Jan 9.

Centre universitaire des maladies rénales, CHU de Caen, avenue de la côte de Nacre, 14033 Caen cedex 9, France; Unicaen, UFR de médecine, Normandie Université, 2, rue des Rochambelles, 14032 Caen cedex, France. Electronic address:

Hypocomplementemic urticarial vasculitis is a rare systemic vasculitis, affecting small vessels, characterised by chronicle urticaria, hypocomplementemia, and systemic manifestations. Renal involvement, whose prevalence varies between 9% and 60%, is mainly glomerular. We here report the case of a 59 years old woman presenting kidney failure, associated with chronicle urticaria and arthralgias. Read More

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http://dx.doi.org/10.1016/j.nephro.2019.09.004DOI Listing

Evidence for bradykinin release in chronic spontaneous urticaria.

Clin Exp Allergy 2020 Mar 21;50(3):343-351. Epub 2020 Jan 21.

Laboratory of Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Background: Chronic spontaneous urticaria (CSU) is characterized by recurrent itchy weals and/or angioedema and is believed to be driven by mast cell activation. It was shown that excessive mast cell activation during anaphylaxis initiates contact activation, resulting in bradykinin release. Evidence for bradykinin release was never demonstrated in CSU. Read More

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http://dx.doi.org/10.1111/cea.13558DOI Listing

Level of interleukin-18 binding protein is significantly different in patients with anaphylaxis than urticaria.

Asian Pac J Allergy Immunol 2019 Dec 14. Epub 2019 Dec 14.

Department of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Background: Acute urticaria is a common cutaneous disease encountered in children, while anaphylaxis can show cutaneous symptoms as well as systemic symptoms. One study found that urticaria tends to precede anaphylaxis, but studies on the different role of eosinophils and related cytokines in anaphylaxis and urticaria are lacking.

Objective: The aim of this study was to compare the clinical features, total eosinophil count, serum levels of interleukin (IL)-18, IL-18 binding protein (BP), IL-1 receptor-like (RL) 1, and IL-33 and compare with tryptase to examine if any differences could be found between patients who experienced anaphylaxis and urticaria. Read More

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http://dx.doi.org/10.12932/AP-270619-0588DOI Listing
December 2019

Anaphylaxis for Internists: Definition, Evaluation, and Management, with a Focus on Commonly Encountered Problems.

Med Clin North Am 2020 Jan;104(1):25-44

Department of Medicine, McMaster University, 1200 Main Street West, HSC-3V49, Hamilton, Ontario L8N 3Z5, Canada. Electronic address:

Anaphylaxis is an acute systemic allergic reaction that can be life threatening. In adults, the most common causes of anaphylaxis are foods, drugs, and insect stings. This article reviews the definition, classification, evaluation, differential diagnosis, prognosis, complications, and management of anaphylaxis. Read More

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http://dx.doi.org/10.1016/j.mcna.2019.08.007DOI Listing
January 2020

Approach to the Patient with Hives.

Med Clin North Am 2020 Jan 28;104(1):15-24. Epub 2019 Oct 28.

University of Cincinnati Department of Internal Medicine, Division of Immunology, Allergy Section, University of Cincinnati, 231 Albert Sabin Way, ML#563, Cincinnati, OH 45267, USA; Bernstein Allergy Group, 8444 Winton Road, Cincinnati, OH 45231, USA. Electronic address:

Urticaria is a common presenting problem to the primary care provider. Acute urticaria lasting less than 6 weeks may be associated with a drug or food allergens. Chronic urticaria lasting more than 6 weeks is often associated without a known underlying cause. Read More

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http://dx.doi.org/10.1016/j.mcna.2019.08.010DOI Listing
January 2020