Search our Database of Scientific Publications and Authors

I’m looking for a

    2154 results match your criteria Urticaria Acute

    1 OF 44

    [Urticaria multiforme: difficult to distinguish from other skin conditions].
    Ned Tijdschr Geneeskd 2018 ;162(0):D2251
    Westfriesgasthuis, afd. Kindergeneeskunde en Neonatologie, Hoorn.
    Background: Urticaria multiforme is a rare clinical variant of urticaria that occurs specifically in children.

    Case Description: A boy aged 11 months was presented at the Emergency Department with acute onset of itching urticarial skin weals and acral oedema. This picture is consistent with the diagnosis of urticaria multiforme. Read More

    Twenty years' experience with anaphylaxis-like reactions to local anesthetics: genuine allergy is rare.
    J Allergy Clin Immunol Pract 2018 Apr 12. Epub 2018 Apr 12.
    Department of Dermatology, Venereology and Allergy, University Hospital Würzburg, Germany.
    Background: Anaphylaxis-like reactions occur within minutes after application of local anesthetics (LA), most commonly during dental interventions. Impressive symptoms including respiratory distress or loss of consciousness frequently give rise to a suspicion of allergy and may prompt patients and treating physicians to refuse future LA injections.

    Objective: Non-allergic mechanisms are responsible for the majority of LA-induced immediate-type reactions. Read More

    Identification of pyruvate kinase as a novel allergen in whiteleg shrimp (Litopenaeus vannamei) by specific-IgE present in patients with shrimp allergy.
    Food Chem 2018 Aug 21;258:359-365. Epub 2018 Mar 21.
    Department of Food Science, National Pingtung University of Science and Technology, Pingtung 912, Taiwan. Electronic address:
    Food allergy is one of the most important health issues worldwide. In Taiwan, current literature suggests shrimps and crabs are the most common causes of food allergy, and are frequently associated with acute allergic reactions such as urticaria, atopic dermatitis, and asthma. However, knowledge regarding the shrimp allergens remains limited. Read More

    Management of anaphylaxis in Spain: pediatric emergency care providers' knowledge.
    Eur J Emerg Med 2018 Apr 4. Epub 2018 Apr 4.
    Department of Pediatric Emergency, Cruces University Hospital - Basque Country University.
    Background: Acute care providers must diagnose and treat patients with anaphylaxis. The objective was to analyze Spanish pediatric emergency departments' (ED) providers' knowledge of the international recommendations for the management of anaphylaxis.

    Methods: A web-based survey including providers (both attending and residents) from seven Spanish pediatric EDs was conducted. Read More

    Epidemiology of urticaria in Poland - nationally representative survey results.
    Postepy Dermatol Alergol 2018 Feb 20;35(1):67-73. Epub 2018 Feb 20.
    Department of Prevention of Environmental Hazards and Allergology, Medical University of Warsaw, Warsaw, Poland.
    Introduction: The prevalence of urticaria is 15-20%. Women are twice as likely to be affected.

    Aim: To present the epidemiology of urticaria and angioedema in Poland. Read More

    Analysis of related factors of orolingual angioedema after rt-PA intravenous thrombolytic therapy.
    Eur Rev Med Pharmacol Sci 2018 Mar;22(5):1478-1484
    Department of Internal Neurology, Tianjin Huanhu Hospital, Tianjin, China.
    Objective: Orolingual angioedema (OA) is a rare clinical complication with a potentially fatal risk that occurs after the intravenous application of alteplase (rt-PA) in patients with acute ischemic stroke. The purpose of this work is to investigate the related factors of OA in patients with acute ischemic stroke after the administration of intravenous thrombolytic therapy, to improve the predictive ability of OA during intravenous thrombolytic therapy, and to reduce the prevalence of complications.

    Patients And Methods: We recruited 1223 cases of patients with acute ischemic stroke that were treated in the Department of Neurology No. Read More

    Refractory Abdominal Pain in a Patient with Chronic Lymphocytic Leukemia: Be Wary of Acquired Angioedema due to C1 Esterase Inhibitor Deficiency.
    Case Rep Hematol 2018 10;2018:7809535. Epub 2018 Jan 10.
    Department of Medicine, Reading Hospital, West Reading, PA, USA.
    Acquired angioedema due to C1 inhibitor deficiency (C1INH-AAE) is a rare and potentially fatal syndrome of bradykinin-mediated angioedema characterized by episodes of angioedema without urticaria. It typically manifests with nonpitting edema of the skin and edema in the gastrointestinal (GI) tract mucosa or upper airway. Edema of the upper airway and tongue may lead to life-threatening asphyxiation. Read More

    Contact dermatitis and patch testing for the allergist.
    Ann Allergy Asthma Immunol 2018 Mar 6. Epub 2018 Mar 6.
    Allergy and Immunology Fellow, NYU Winthrop Hospital, Mineola, New York.
    Objective: Contact dermatitis (CD) is a common disease seen by allergists. Although underutilized, patch testing (PT) remains the gold standard in the diagnosis of allergic CD. It is not difficult to perform, however, the interpretation of the PT, proper classification of the results and determination of their relevance, need an appropriate level of expertise. Read More

    Clinical profile of dermatological emergencies and intensive care unit admissions in a tertiary care center - an Indian perspective.
    Int J Dermatol 2018 May 26;57(5):575-579. Epub 2018 Feb 26.
    Father Muller Medical College, Mangalore, Karnataka, India.
    Background: Although dermatology is largely considered as an outpatient specialty, dermatological conditions comprise 5-8% of cases presenting to the emergency department. The need for a dermatological intensive care unit is widely acknowledged due to the increasing incidence of acute skin failure. Very few studies have been done to characterize the common conditions seen in the emergency department and intensive care units. Read More

    Anaphylactoid Reactions to Intravenous N-Acetylcysteine during Treatment for Acetaminophen Poisoning.
    J Med Toxicol 2018 Feb 8. Epub 2018 Feb 8.
    Department of Pediatrics, University of Colorado School of Medicine, Denver, CO, USA.
    Background: Anaphylactoid reactions to intravenous (IV) N-acetylcysteine (NAC) are well-recognized adverse events during treatment for acetaminophen (APAP) poisoning. Uncertainty exists regarding their incidence, severity, risk factors, and management. We sought to determine the incidence, risk factors, and treatment of anaphylactoid reactions to IV NAC in a large, national cohort of patients admitted to hospital for acetaminophen overdose. Read More

    Vaccine-associated hypersensitivity.
    J Allergy Clin Immunol 2018 Feb;141(2):463-472
    Immunization Safety Office, Centers for Disease Control and Prevention, Atlanta, Ga.
    Vaccine-associated hypersensitivity reactions are not infrequent; however, serious acute-onset, presumably IgE-mediated or IgG and complement-mediated anaphylactic or serious delayed-onset T cell-mediated systemic reactions are considered extremely rare. Hypersensitivity can occur because of either the active vaccine component (antigen) or one of the other components. Postvaccination acute-onset hypersensitivity reactions include self-limited localized adverse events and, rarely, systemic reactions ranging from urticaria/angioedema to full-blown anaphylaxis with multisystem involvement. Read More

    Hypocomplementemic Urticarial Vasculitis Syndrome With Crescentic Glomerulonephritis.
    Am J Med Sci 2018 Feb 8;355(2):195-200. Epub 2017 Apr 8.
    Department of Internal Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
    Hypocomplementemic urticarial vasculitis syndrome (HUVS) is a rare autoimmune disease characterized by multiple organ system involvement, including renal disease, with low complement levels. We report the case of a 31-year-old woman who presented with nonspecific symptoms including fatigue, diarrhea, macular rash and abdominal pain with acute renal failure leading to end-stage kidney disease. Laboratory results showed hematuria, nephrotic range proteinuria, worsening creatinine and low C1q levels. Read More

    Establishing a Safe Administration of ASA in Cardiovascular Patients with Nonsteroidal Anti-Inflammatory Drug Hypersensitivity with Skin and/or Respiratory Involvement.
    Int Arch Allergy Immunol 2018 26;175(4):237-245. Epub 2018 Jan 26.
    Sabah Al Ahmed Cardiac Center, Ministry of Health, Kuwait City, Kuwait.
    Background: A history of nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity with cross-intolerance to several drugs is common in some patients with coronary artery disease. We present a series of patients with acute coronary syndrome undergoing ASA desensitization prior to a possible stent to evaluate the short- and long-term efficacy and safety. The aim was to evaluate the outcomes of an ASA desensitization protocol developed by our center based on the guidelines proposed by the EAACI drug allergy expert recommendations. Read More

    Anaphylaxis in a food allergy outpatient department: one-year review.
    Eur Ann Allergy Clin Immunol 2018 Mar 30;50(2):81-88. Epub 2017 Nov 30.
    Allergy and Clinical Immunology Department, Coimbra University Center, Coimbra, Portugal.
    Summary: Anaphylaxis is an acute, potentially fatal, multi-organ allergic reac-tion. Our aim was to characterize the population with food induced anaphylaxis followed over a one-year period. Retrospective analysis of clinical files of patients with food anaphylaxis observed in our food allergy consultation during 2016. Read More

    Resolution of unilateral sensorineural hearing loss in a pediatric patient with a severe phenotype of Muckle-Wells syndrome treated with Anakinra: a case report and review of the literature.
    J Otolaryngol Head Neck Surg 2018 Jan 30;47(1). Epub 2018 Jan 30.
    Department of Pediatric Otolaryngology Head and Neck Surgery, McGill University Health Center, Montreal Children's Hospital, 1001, boul. Décarie - Local A02.3017, Montreal, QC, H4A 3J1, Canada.
    Background: Muckle-Wells syndrome (MWS) is a rare auto-inflammatory disease characterized by the presence of recurrent urticaria, deafness and amyloidosis. Progressive sensorineural hearing loss (SNHL) is reported to occur in up to 85% of patients occurring in the second and third decades and as early as the first decade in patients with a more severe phenotype, thus potentially having a significant impact on a child's development. IL-1 inhibitors, such as Anakinra, have been described to improve systemic inflammation, and stabilize or improve hearing status as well. Read More

    The EAACI/GA²LEN/EDF/WAO Guideline for the Definition, Classification, Diagnosis and Management of Urticaria. The 2017 Revision and Update.
    Allergy 2018 Jan 15. Epub 2018 Jan 15.
    Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Dermatology and Allergy, Allergy-Centre-Charité.
    This evidence and consensus-based guideline was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. The conference was held on December 1st, 2016. It is a joint initiative of the Dermatology Section of the European Academy of Allergology and Clinical Immunology (EAACI), the EU-founded network of excellence, the Global Allergy and Asthma European Network (GA²LEN), the European Dermatology Forum (EDF), and the World Allergy Organization (WAO) with the participation of 48 delegates of 42 national and international societies. Read More

    Evaluation of Patients Visiting the Dermatology Emergency Unit of a University Dermatology Hospital in Tehran, Iran.
    Acta Med Iran 2017 Nov;55(11):705-711
    Department of Dermatology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. AND Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran.
    Published studies on dermatological emergencies are limited in the literature. To our knowledge, no study has previously explored this subject in Iran. Our aim was to ascertain the characteristics of patients visiting the dermatologic emergency (DE) unit of a university skin hospital in Tehran, Iran. Read More

    Cause and Clinical Presentation of Anaphylaxis in Singapore: From Infancy to Old Age.
    Int Arch Allergy Immunol 2018 5;175(1-2):91-98. Epub 2018 Jan 5.
    Department of Allergy and Immunology, KK Women's and Children's Hospital, Singapore, Singapore.
    Background: The study objective was to compare age-related differences in the cause and clinical presentation of anaphylaxis.

    Methods: We conducted a prospective study of patients visiting the emergency department for anaphylaxis. Data were collected from 3 emergency departments from 1 April 2014 to 31 December 2015. Read More

    Gene mutations and clinical phenotypes in 15 Chinese children with cryopyrin-associated periodic syndrome (CAPS).
    Sci China Life Sci 2017 Dec 2;60(12):1436-1444. Epub 2017 Dec 2.
    Department of Rheumatology and Immunology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China.
    The aim of our study is to explore the features of clinical manifestations and genetic mutations in Chinese CAPS patients. Fifteen confirmed patients with CAPS were enrolled. The onset time ranges from 2 days after birth to 6 years and 1 month. Read More

    Elevated circulating heat shock protein 70 and its antibody concentrations in chronic spontaneous urticaria.
    Int J Immunopathol Pharmacol 2018 Jan-Dec;31:394632017750440. Epub 2017 Dec 22.
    1 Department of Internal Diseases, Dermatology and Allergology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland.
    Heat shock proteins (Hsp) play a complex role in cytoprotection, inflammation, and function of the immune system. They may be involved in pathogenesis of various diseases. Our aim was to determine circulating Hsp70 and anti-Hsp70 antibodies concentrations in patients with chronic spontaneous urticaria (CSU). Read More

    Elevated plasma il-8 concentration is related to severity of systemic inflammation in chronic spontaneous urticaria.
    J Biol Regul Homeost Agents 2017 Oct-Dec;31(4):957-961
    Department of Internal Diseases, Dermatology and Allergology in Zabrze, SMDZ in Zabrze, Medical University of Silesia in Katowice, Poland.
    Chronic spontaneous urticaria (CSU) is associated with activation of acute phase response. Questions arise regarding its association with other inflammatory mediators. To determine plasma IL-8 concentration in CSU patients and its association with C-reactive protein (CRP) concentration, a nonspecific inflammatory marker of the disease activity, concentrations of plasma IL-8 and serum CRP were measured in CSU patients and compared with healthy controls. Read More

    Nicolau's syndrome: A rare but preventable iatrogenic disease.
    Acta Dermatovenerol Croat 2017 Oct;25(3):251-253
    Assist. Prof. Tasleem Arif, MD, Postgraduate Department of Dermatology, STDs and Leprosy, Jawaharlal Nehru Medical College (JNMC), Aligarh Muslim University, Aligarh, India;
    Dear Editor, Nicolau's syndrome, also called embolia cutis medicamentosa or livedoid dermatitis, is a rare injection site reaction characterized by immediate intense pain at the injection site followed by erythema and a hemorrhagic patch with a livedoid reticular pattern after injections of non-steroidal anti-inflammatory drugs (NSAIDS), antiepileptics, antibiotics, antihistaminics, corticosteroids, etc. (1). To the best of our knowledge, only one case of Nicolau's syndrome has been reported after the use of triamcinolone acetonide. Read More

    Investigational drugs in phase I and phase II clinical trials for hereditary angioedema.
    Expert Opin Investig Drugs 2018 Jan 15;27(1):87-103. Epub 2017 Dec 15.
    a Hungarian Angioedema Center, 3rd Department of Internal Medicine , Semmelweis University , Budapest , Hungary.
    Introduction: Hereditary angioedema (HAE) with C1-inhibitor deficiency (C1-INH-HAE) is a rare bradykinin-mediated disease characterized by recurrent subcutaneous and/or submucosal angioedematous attacks (HAE attacks), which occur unpredictably. The recurrent HAE attacks do not respond to conventional treatments, and may evolve into a life-threatening condition; therefore, special therapy is required. Areas covered: The agents used so far for the acute management of HAE attacks act by blocking the release of bradykinin, or its binding to its receptor. Read More

    Phosgene oxime: Injury and associated mechanisms compared to vesicating agents sulfur mustard and lewisite.
    Toxicol Lett 2017 Nov 12. Epub 2017 Nov 12.
    Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA. Electronic address:
    Phosgene Oxime (CX, ClCNOH), a halogenated oxime, is a potent chemical weapon that causes immediate acute injury and systemic effects. CX, grouped together with vesicating agents, is an urticant or nettle agent with highly volatile, reactive, corrosive, and irritating vapor, and has considerably different chemical properties and toxicity compared to other vesicants. CX is absorbed quickly through clothing with faster cutaneous penetration compared to other vesicating agents causing instantaneous and severe damage. Read More

    [Acute hemorrhagic edema of infancy: alarming lesions of a benign condition. Case report].
    Arch Argent Pediatr 2017 12;115(6):e432-e435
    Salud total EPS, Urbanización El Bosque.
    We report a case of acute hemorrhagic edema of infancy in an 18-month-old boy after an episode of otitis media. The clinical presentation begins with skin erythematous macules on the thighs, followed by purpuric lesions in arms, legs, and ankle edema. It was initially interpreted as urticaria, whereby steroids were indicated. Read More

    Analysis of pediatric dermatology inpatient consultations in a pediatric teaching hospital.
    Arch Argent Pediatr 2017 12;115(6):e377-e384
    Ataturk Research and Training Hospital, Department of Dermatology, Izmir, Turkey.
    Introduction: Although skin diseases are associated with low rate of hospitalization, dermatological manifestations are frequent in hospitalized patients. The aim of the study was to describe the inpatient dermatological consultations in a pediatric teaching hospital.

    Population And Methods: Recorded data from inpatient pediatric dermatology consultation requests on a total of 539 consecutive inpatients (aged 0-18 years) from January 2004 to April 2010 were analyzed for consult diagnosis, dermatological disease group, primary diagnosis, requesting department, diagnostic pattern, treatment modality and referral to another department. Read More

    Severe forms of food allergy.
    J Pediatr (Rio J) 2017 Nov - Dec;93 Suppl 1:53-59. Epub 2017 Sep 21.
    Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil; Universidade Federal de Pernambuco (UFPE), Programa de Residência Médica em Gastropediatria, Recife, PE, Brazil.
    Objectives: To guide the diagnostic and therapeutic management of severe forms of food allergy.

    Data Sources: Search in the Medline database using the terms "severe food allergy," "anaphylaxis and food allergy," "generalized urticaria and food allergy," and "food protein-induced enterocolitis syndrome" in the last ten years, searching in the title, abstract, or keyword fields.

    Summary Of Data: Food allergy can be serious and life-threatening. Read More

    Angioedema without urticaria caused by oral acitretin.
    Acta Dermatovenerol Alp Pannonica Adriat 2017 09;26(3):67-68
    Department of Dermatology, University of Patras, Rio-Patras,Greece.
    The efficacy of oral acitretin in the systemic treatment of severe and recalcitrant dermatoses has been established in a large number of clinical trials. Its mucocutaneous and ocular adverse reactions are common or relatively common, whereas systemic side effects are either uncommon or rare and include teratogenesis, hyperlipidemia, hepatotoxicity, intracranial hypertension, myopathy, and peripheral neuropathy. Angioedema is a term used to describe an acute, solitary or multiple, circumscribed, and non-pitting mucocutaneous swelling that affects the dermis and the subcutaneous tissue, lasts 24 to 72 hours, and may become potentially life-threatening when the pharynx and/or the larynx are involved. Read More

    [Acute skin infections and their imitators in children : A photo quiz].
    Hautarzt 2017 Oct;68(10):774-783
    Abteilung pädiatrische Dermatologie, Universitäts-Kinderspital Zürich, Steinwiesstrasse 75, 8032, Zürich, Schweiz.
    Background: Skin infections account for 40% of emergency visits in pediatric dermatology. It is important to promptly recognize skin infections with potential complications and initiate treatment. However some characteristic skin findings may imitate skin infections and are often misdiagnosed. Read More

    The Histopathology of Urticaria Revisited-Clinical Pathological Study.
    Am J Dermatopathol 2017 Oct;39(10):753-759
    *Department of Dermatology, Sheba Medical Center, Tel-Hashomer, Israel; and †Institute of Pathology, Sheba Medical Center, Tel Hashomer, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
    Background: The classic histopathological findings of urticaria include dermal edema and a sparse perivascular infiltrate of neutrophils, eosinophils, macrophages, and lymphocytes. However, this pattern is inconsistently described.

    Objective: To describe the histological and immunofluorescence characteristics of urticaria and to identify distinctive patterns. Read More

    In Vitro Anti-Inflammatory Activity of Ilex cornuta Extract Mediated by Inhibition of Extracellular Signal-Regulated Kinase Phosphorylation.
    J Med Food 2017 Oct 30;20(10):981-988. Epub 2017 Aug 30.
    College of Pharmacy, Chung-Ang University , Seoul, Korea.
    Ilex cornuta, commonly known as Chinese holly, is an evergreen shrub from the family Aquifoliaceae, and it is widely distributed in Korea and China. In folk medicine, the leaves of I. cornuta are used for treatment of several disorders, including weakness of the waist and knees, arthrodynia, headache, acute conjunctivitis, toothache, urticaria, rheumatic arthralgia, and cardiovascular diseases. Read More

    Different expression patterns of plasma Th1-, Th2-, Th17- and Th22-related cytokines correlate with serum autoreactivity and allergen sensitivity in chronic spontaneous urticaria.
    J Eur Acad Dermatol Venereol 2018 Mar 14;32(3):441-448. Epub 2017 Sep 14.
    Department of Dermatology, Southwest Hospital, Third Military Medical University, Chongqing, China.
    Background: Clinical features and basophil activation levels correlate with serum autoreactivity and allergen sensitivity in patients with chronic spontaneous urticaria (CSU).

    Objectives: To explore the relationship of the expression patterns of plasma T-helper cell (Th) 1-, Th2-, Th17- and Th22-related cytokines with the serum autoreactivity and the allergen sensitivity in CSU.

    Method: Twenty related cytokines were measured and analysed in 60 patients with CSU, 15 patients with acute urticaria, 10 patients with atopic dermatitis (AD) and 15 healthy persons, respectively. Read More

    Allergy-like immediate reactions with herbal medicines in children: A retrospective study using data from VigiBase.
    Pediatr Allergy Immunol 2017 Nov 3;28(7):668-674. Epub 2017 Oct 3.
    Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy, Charles University in Prague, Hradec Kralove, Czech Republic.
    Background: The use of herbal medicines in children and the general population is continually on the rise with an overall herbal lifetime and current use ranging between 0.8%-85.5% and 2. Read More

    Dtsch Arztebl Int 2017 Jul;114(29-30):489-496
    Department of Otorhinolaryngology, Ulm University Hospital; Department of Anaesthesiology, Ulm University Hospital.
    Background: Acute angioedema of the upper airways can be life-threatening. An important distinction is drawn between mast-cell-mediated angioedema and bradykinin-mediated angioedema; the treatment of these two entities is fundamentally different.

    Methods: This review is based on pertinent articles retrieved by a selective search in PubMed and on guidelines concerning the treatment of angioedema. Read More

    Urticaria vasculitis in a child: a case report and literature review.
    Clin Case Rep 2017 Aug 21;5(8):1255-1257. Epub 2017 Jun 21.
    Department of DermatologyHospital Universitario Severo OchoaAvenida de Orellana28911LeganésMadridSpain.
    Annular urticarial lesions in a child must establish a main differential diagnosis with urticaria multiforme, common urticaria, acute hemorrhagic edema of infancy, erythema marginatum, erythema annulare centrifugum, annular erythema in childhood, erythema multiforme, Sweet's syndrome, Schönlein-Henoch purpura, erythematosus lupus, several systemic vasculitis, and serum sickness. Read More

    Urticaria and Angioedema: an Update on Classification and Pathogenesis.
    Clin Rev Allergy Immunol 2018 Feb;54(1):88-101
    Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, 3010, Bern, Switzerland.
    Urticaria is a common, mast cell-driven disease presenting with wheals or angioedema or both. In the last years, urticaria has increasingly attracted notice to clinicians and researchers, last but not least inspired by the approval of omalizumab, an anti-IgE antibody, for urticaria treatment. There is wide consensus on the clinical classification based on duration and elicitation. Read More

    [Clinical characteristics of urticaria in children versus adults].
    Zhongguo Dang Dai Er Ke Za Zhi 2017 Jul;19(7):790-795
    Department of Dermatology, Xiangya Hospital, Central South University, Changsha 410008, China.
    Objective: To study the clinical characteristics of urticaria in children versus adults, and to provide reference for the etiological analysis, disease evaluation, and treatment of urticaria in children.

    Methods: The clinical data of 2 411 patients with urticaria who visited the Department of Dermatology at Xiangya Hospital of Central South University from January 2013 to May 2017 were collected to study their socio-demographic characteristics. The clinical characteristics of urticaria were compared between the 68 children and 672 adults of the 740 patients with complete follow-up data. Read More

    Emerging Therapies in Hereditary Angioedema.
    Immunol Allergy Clin North Am 2017 08;37(3):585-595
    Division of Rheumatology, Department of Medicine, Allergy & Immunology, University of California San Diego, 8899 University City Lane, Suite 230, San Diego, CA 92122, USA.
    Remarkable progress has been made in the treatment of bradykinin-mediated angioedema with the advent of multiple new therapies. Patients now have effective medications available for prophylaxis and treatment of acute attacks. However, hereditary angioedema is a burdensome disease that can lead to debilitating and dangerous angioedema episodes associated with significant costs for individuals and society. Read More

    Acute Management of Hereditary Angioedema Attacks.
    Immunol Allergy Clin North Am 2017 08 23;37(3):541-556. Epub 2017 May 23.
    Immunology and Allergy Unit, Department of Medicine, Campbelltown Hospital, Therry Road, Campbelltown, Sydney, New South Wales 2560, Australia. Electronic address:
    Several treatment modalities have become available for management of acute hereditary angioedema (HAE) attacks in the last 15 years. Most are now available to patients in North America, Europe, United Kingdom, and Australia, but few options exist in developing countries. Preferred contemporary use of the treatments to be discussed is "on demand," because control remains with the patient and delays in treatment access avoided. Read More

    Laboratory Approaches for Assessing Contact System Activation.
    Immunol Allergy Clin North Am 2017 08;37(3):527-539
    Department of Medicine, University of California, 9500 Gilman Drive, Mailcode 0732, La Jolla, CA 92093, USA; San Diego Veterans Administration Healthcare System, Medicine Service, 3350 La Jolla Village Drive, San Diego, CA 92161, USA. Electronic address:
    Hereditary angioedema (HAE) is a rare autosomal dominant disease clinically characterized by recurrent, often unpredictable attacks of subcutaneous and mucosal swelling. Acute episodes are debilitating, painful, disfiguring, and potentially fatal. HAE type I and type II result from a deficiency in the plasma level of functional C1 inhibitor. Read More

    Pathogenesis of Hereditary Angioedema: The Role of the Bradykinin-Forming Cascade.
    Immunol Allergy Clin North Am 2017 08;37(3):513-525
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA.
    Hereditary angioedema (HAE) is an autosomal-dominant disorder owing to mutations in the C1 inhibitor gene. Type I is characterized by a low C1 inhibitor protein level and diminished functional activity, whereas type II has a normal (or elevated) protein level but diminished function. When functional levels drop beyond 40% of normal, attacks of swelling are likely to occur due to overproduction of bradykinin. Read More

    Histaminergic Angioedema.
    Immunol Allergy Clin North Am 2017 08 13;37(3):467-481. Epub 2017 May 13.
    Division of Allergy and Clinical Immunology, Icahn School of Medicine at Mount Sinai, 1425 Madison Avenue, New York, NY 10029-6574, USA.
    Angioedema is frequently categorized into histamine- or bradykinin-mediated disease. It is critical to determine the underlying mediator of symptoms as it directs treatment. Histaminergic angioedema is the most frequent cause of angioedema. Read More

    Decreased plasma kallikrein 5 concentrations in patients with chronic spontaneous urticaria.
    J Biol Regul Homeost Agents 2017 Apr-Jun;31(2):407-411
    Department of Internal Diseases, Dermatology and Allergology in Zabrze, SMDZ in Zabrze, Medical University of Silesia in Katowice, Poland.
    Little is known about the role of the kallikrein-kinin system in chronic spontaneous urticaria (CSU). Kallikrein 5 (KLK5), a trypsin-like enzyme, is the most abundant in the skin and plays a role in itching and inflammatory reaction. In this study, we determined plasma KLK5 concentration, and its associations with acute phase response in CSU patients. Read More

    Acute and Chronic Urticaria: Evaluation and Treatment.
    Am Fam Physician 2017 Jun;95(11):717-724
    University of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
    Urticaria commonly presents with intensely pruritic wheals, sometimes with edema of the subcutaneous or interstitial tissue. It has a lifetime prevalence of about 20%. Although often self-limited and benign, it can cause significant discomfort, continue for months to years, and uncommonly represent a serious systemic disease or life-threatening allergic reaction. Read More

    Patient satisfaction and experience with intravenously administered C1-inhibitor concentrates in the United States.
    Ann Allergy Asthma Immunol 2017 07;119(1):59-64
    CSL Behring, King of Prussia, Pennsylvania.
    Background: Hereditary angioedema (HAE) is a rare genetic disorder with substantial morbidity and mortality. Despite expanded choices for effective acute treatment, prophylactic options are more limited. Intravenous C1 esterase inhibitor (C1-INH[IV]) is licensed and used to prevent HAE symptoms. Read More

    Preventing Hereditary Angioedema Attacks in Children Using Cinryze®: Interim Efficacy and Safety Phase 3 Findings.
    Int Arch Allergy Immunol 2017 30;173(2):114-119. Epub 2017 Jun 30.
    Department for Children and Adolescents, Angioedema Centre, University Hospital Frankfurt, Goethe University, Frankfurt, Germany.
    Background: Hereditary angioedema (HAE) is a rare genetic disease causing unpredictable and potentially life-threatening subcutaneous and submucosal edematous attacks. Cinryze® (Shire ViroPharma Inc., Lexington, MA, USA), a nanofiltered C1 inhibitor (C1-INH), is approved in Europe for the treatment, preprocedure prevention, and routine prophylaxis of HAE attacks, and for the routine prophylaxis of attacks in the USA. Read More

    1 OF 44