2,636 results match your criteria Urticaria Acute

Management of allergic reactions and anaphylaxis in the emergency department.

Emerg Med Pract 2022 Jul 1;24(7):1-24. Epub 2022 Jul 1.

Associate Professor of Emergency Medicine, University of Virginia School of Medicine, Charlottesville, VA.

An acute allergic reaction is a rapid-onset, IgE-mediated hypersensitivity reaction. Although it is most commonly caused by food, insect stings, and medications, there are many additional causes. Symptoms can range from mild urticaria and swelling, to abdominal cramping, to respiratory collapse. Read More

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Urticaria and angioedema in children and adolescents: diagnostic challenge.

Allergol Immunopathol (Madr) 2022 17;50(S Pt 1):17-29. Epub 2022 May 17.

Division of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, McGill University Health Centre, Montreal, Canada.

Urticaria diagnosis may be challenging in children since it can be triggered or related to numerous conditions. In this paper, we reviewed the main aspects regarding the diagnosis of urticaria in the pediatric population. Acute urticaria is often due to viral infections. Read More

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The Potential Role of Basophils in Urticaria.

Front Immunol 2022 17;13:883692. Epub 2022 May 17.

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Urticaria is a symptom of acute skin allergies that is not clearly understood, but mast cell histamine is hypothesized to cause swelling and itching. Omalizumab, an anti-human IgE antibody that traps IgE and prevents its binding to high-affinity IgE receptors, is effective in treating urticaria. We recently experienced a case of urticaria refractory to antihistamine therapy in which the peripheral-blood basophil count responded to omalizumab therapy and its withdrawal. Read More

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Chlorpheniramine, an Old Drug with New Potential Clinical Applications: A Comprehensive Review of the Literature.

Curr Rev Clin Exp Pharmacol 2022 Jun 1. Epub 2022 Jun 1.

Lake Erie College of Osteopathic Medicine, Bradenton, FL, USA.

Chlorpheniramine Maleate (CPM), also known as chlorphenamine, is a potent alkylamine first-generation H1 antihistamine that has been around since the 1950s. CPM is a widely popular drug commonly used to treat allergic conditions, given its antihistamine properties. Although mainly used in over-the-counter treatment for cough and colds, various studies discuss a wide range of CPM's clinical uses, such as treating asthma, plasma cell gingivitis, chronic urticaria, depression, among others. Read More

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Cutaneous Manifestations of Coronavirus Disease 2019: Skin Narratives and Dialogues.

J Clin Aesthet Dermatol 2022 May;15(5):E77-E81

Drs. Mohammed and Atef are with the Department of Dermatology and Venereology, Faculty of Medicine at the Suez Canal University in Ismailia, Egypt.

Background: Although the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is primarily responsible for respiratory symptoms, an increasing number of cutaneous manifestations have been reported. Cutaneous manifestations are reported by patients following disease recovery.

Objective: We sought to document various skin lesions relating to COVID-19 symptoms either before, during, or after infection with severe acute respiratory syndrome coronavirus 2. Read More

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Clinical and Socio-Demographic Variables Associated with the Diagnosis of Long COVID Syndrome in Youth: A Population-Based Study.

Int J Environ Res Public Health 2022 05 15;19(10). Epub 2022 May 15.

ADHD Unit, Geha Mental Health Center, Petah Tikva 49100, Israel.

This study examines the demographic, clinical and socioeconomic factors associated with diagnosis of long COVID syndrome (LCS). Data of 20,601 COVID-19-positive children aged 5 to 18 years were collected between 2020 and 2021 in an Israeli database. Logistic regression analysis was used to evaluate the adjusted odds ratio for the characteristics of the COVID-19 infection and pre-COVID-19 morbidities. Read More

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Benefits and Harms of Treatment and Preventive Interventions for Hereditary Angioedema: Protocol for a Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.

Genes (Basel) 2022 May 22;13(5). Epub 2022 May 22.

Pharmacoepidemiology and Statistics Research Center (PESRC), Chiang Mai University, Chiang Mai 50200, Thailand.

Background: Hereditary angioedema (HAE) is a rare genetic disease that can lead to potentially life-threatening airway attacks. Although novel therapies for HAE treatment have become available over the past decades, a comparison of all available treatments has not yet been conducted. As such, we will perform a systematic review and network meta-analysis to identify the best evidence-based treatments for the management of acute attacks and prophylaxis of HAE. Read More

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Facial Angioedema after the first dose of Covishield (adenovirus-vectored severe acute respiratory syndrome coronavirus 2 vaccine): follow-up after the second and third booster doses.

Rev Soc Bras Med Trop 2022 20;55:e00632022. Epub 2022 May 20.

Universidade Federal do Estado do Rio de Janeiro, Hospital Universitário Gaffrée e Guinle, Rio de Janeiro, RJ, Brasil.

Mass vaccination campaigns are essential to control the ongoing novel severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) pandemic. The Covishield vaccine consists of the replication-deficient simian adenovirus vector ChAdOx1, which contains the full-length structural spike protein of SARS-CoV-2. Occasionally, it can lead to cutaneous reactions that contribute to fear of vaccination, hesitancy, and incomplete vaccination schedules. Read More

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Cutaneous Allergic reactions to pine processionary caterpillar (Thaumetopoea Pityocampa): a complicated cutaneous reaction in an infant and review of the literature.

Turk J Pediatr 2022 ;64(2):389-393

Division of Pediatric Allergy & Immunology, Near East University, Faculty of Medicine, Nicosia, North Cyprus.

Background: Thaumetopoea Pityocampa (TP) are frequent in the Mediterranean region especially affecting forest workers in pinewood areas. The common symptoms include swelling, rash or burns like any form of dermatitis. The reactions can be triggered by mechanical, chemical or allergic factors and the `allergic` reaction is caused by sensitization to a hair protein named `thaumetopoein`. Read More

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Anaphylaxis in Chinese Children with Pollen Sensitization: Triggers, Clinical Presentation, and Acute Management.

J Asthma Allergy 2022 16;15:633-643. Epub 2022 May 16.

Department of Allergy, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health; Key Laboratory of Major Diseases in Children, Ministry of Education; National Clinical Research Center for Respiratory Diseases, Beijing, People's Republic of China.

Purpose: Pollen sensitization is increasing in children. However, there is little evidence regarding the characteristics of anaphylaxis in individuals with pollen sensitization.

Patients And Methods: We conducted a retrospective study of patients with anaphylaxis combined with pollen sensitization who attended an allergy department in a tertiary children's hospital from 2014 to 2021. Read More

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Outpatient administration of naxitamab in combination with granulocyte-macrophage colony-stimulating factor in patients with refractory and/or relapsed high-risk neuroblastoma: Management of adverse events.

Cancer Rep (Hoboken) 2022 May 17:e1627. Epub 2022 May 17.

Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Background: Naxitamab is a humanized GD2-binding monoclonal antibody that received accelerated approval from the U.S. Food and Drug Administration for refractory or relapsed high-risk neuroblastoma limited to bone or bone marrow. Read More

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Insights into urticaria in pediatric and adult populations and its management with fexofenadine hydrochloride.

Allergy Asthma Clin Immunol 2022 May 13;18(1):41. Epub 2022 May 13.

Allergy and Clinical Immunology Department, Centro Médico Docente La Trinidad, Caracas, Venezuela.

Objective: The present narrative review provides a comprehensive update of the current knowledge on urticaria, both in adult and pediatric populations, and on the safety and efficacy of fexofenadine hydrochloride (HCl) as a treatment option.

Data Source: A literature search was conducted on Embase and Medline.

Study Selection: Clinical studies published in English and published between 1999 and 2020 were selected. Read More

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Cutaneous manifestations of coronavirus disease 2019 patients in Japan.

J Dermatol 2022 May 10. Epub 2022 May 10.

Department of Dermatology, Toyonaka Municipal Hospital, Toyonaka, Japan.

Some patients with coronavirus disease 2019 (COVID-19) develop skin manifestations. There may be regional and racial differences in the frequency and type of COVID-19-associated skin manifestations. There are, however, few reports on skin manifestations in COVID-19 patients in Asia, including Japan. Read More

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[Delayed acute urticaria after the third vaccine against SARS-CoV-2].

Semergen 2022 Mar 22. Epub 2022 Mar 22.

Medicina Familiar y Comunitaria, Centro de Salud Olaguíbel, Vitoria-Gasteiz, España.

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Fish Roe-Induced Anaphylaxis in Italy: A Pediatric Case Report.

Pediatr Rep 2022 Apr 8;14(2):170-174. Epub 2022 Apr 8.

Pediatrics and Neonatology Unit, Department of Maternal and Child Health, Guglielmo da Saliceto Hospital, Azienda USL di Piacenza, 29121 Piacenza, Italy.

Fish roe are not yet described as triggers of allergic reactions in Italy, especially during the pediatric age; they are more frequently involved in anaphylaxis in Eastern countries, such as Japan. For this report, we reported a case of anaphylaxis in a 2-year-old boy admitted to our Hospital Pediatric Emergency Room with a suspected allergic reaction. 15 min after the meal, he presented generalized urticaria, angioedema, wheezing, sneezing, and two vomiting episodes. Read More

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Evaluation of association with subtypes and alleles of Blastocystis with chronic spontaneous urticaria.

Acta Trop 2022 Jul 9;231:106455. Epub 2022 Apr 9.

Department of Parasitology, Faculty of Medicine, Ege University, Izmir, Turkey.

Blastocystis is a single-celled parasite commonly found in humans and its pathogenic role is still controversial. In recent years, some studies have suggested that Blastocystis may be a possible agent of gastrointestinal and dermatological symptoms such as acute or chronic urticaria, angioedema, rash, itch, palmoplantar, and diffuse pruritus. We aimed to investigate whether there is a relationship between Blastocystis subtypes and alleles in patients with chronic spontaneous urticaria (CSU) as a case-control study. Read More

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Urticarial vasculitis: Clinical and laboratory findings with a particular emphasis on differential diagnosis.

J Allergy Clin Immunol 2022 Apr;149(4):1137-1149

Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy; Internal Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Electronic address:

Urticarial vasculitis (UV) is a rare cutaneous vasculitis of small vessels characterized by recurrent episodes of wheal-like lesions that tend to last more than 24 hours, healing with a residual ecchymotic postinflammatory hyperpigmentation. The histopathologic pattern of UV is that of leukocytoclastic vasculitis, consisting of fibrinoid necrosis of dermal vessels' walls and neutrophil-rich perivascular inflammatory infiltrates. Although its etiopahogenesis remains still undefined, UV is now regarded as an immune complex-driven disease with activation of the complement cascade, leading to exaggerated production of anaphylatoxins that are responsible for neutrophil recruitment and activation. Read More

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Hereditary angio-oedema with C1 inhibitor deficiency type I, an unusual stroke mimic.

BMJ Case Rep 2022 Apr 7;15(4). Epub 2022 Apr 7.

Neurology, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain.

Hereditary angio-oedema with C1 inhibitor deficiency (C1-INH-HAE) type I is a rare immune disorder characterised by a deficit of functional C1 esterase inhibitor (C1-INH). Recurrent C1-INH-HAE attacks typically present as generalised skin swelling and abdominal pain. Neurological involvement is very unusual, with a few reports of cephalea and recurrent dizziness. Read More

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Pruritus, Allergy and Autoimmunity: Paving the Way for an Integrated Understanding of Psychodermatological Diseases?

Front Allergy 2021 17;2:688999. Epub 2021 Sep 17.

Laboratoire Interactions Epitheliums Neurones, University of Brest, Brest, France.

Pruritus is a key symptom in allergology and dermatology, contributing to the global and huge impact on quality of life related to skin disorders, both those which are not related to a primary dermatosis (illness) and those which are linked with primary skin lesions (disease). This is particularly evident within psychophysiological dermatoses, a group of psychodermatological diseases where there is a primary dermatosis, where psychological stress plays a role, and where pruritus may represent a major and shared symptom. The etiopathogenesis of pruritus in those disorders sheds light on the link among psychopathological features, psychological stress and the subtle interface between allergic and autoimmune mechanisms, where mast cells play a pivotal role. Read More

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September 2021

The Role of Bloodletting and Cupping in Severe Acute Urticaria and Angioedema as Skin Emergencies in Persian Medicine.

J Pharmacopuncture 2022 Mar;25(1):7-14

Department of Persian Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran.

Objectives: Some dermatological diseases can be life-threatening. Urticaria and angioedema are common reasons for patients to seek treatment at an emergency department. Severe, generalized urticaria and angioedema can endanger patients' lives by involving the airways and causing anaphylactic shock. Read More

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Acute urticaria in children: course of the disease, features of skin microbiome.

Postepy Dermatol Alergol 2022 Feb 28;39(1):164-170. Epub 2022 Feb 28.

Department of Dermatology and Venereology, I. M. Sechenov First Moscow State Medical University, Sechenov University, Moscow, Russia.

Introduction: Quantitative and qualitative changes in the microbiome of the skin affect the emergence and course of allergic diseases, in particular, of acute urticaria.

Aim: To investigate the taxonomic composition of the skin microbiota in children with acute urticaria and to study its effect on the course of the disease.

Material And Methods: In total, 75 children with diagnosed acute urticaria at the age of 7--14 years were examined. Read More

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February 2022

Bradykinin-induced angioedema in the emergency department.

Int J Emerg Med 2022 Mar 26;15(1):15. Epub 2022 Mar 26.

McGill University, Montréal, Canada.

Background: Acute airway angioedema commonly occurs through two distinct mechanisms: histamine- and bradykinin-dependent. Although they respond to distinct treatments, these two potentially life-threatening states present similarly. Poor recognition of the bradykinin-dependent pathway leads to treatment errors in the emergency department (ED), despite the availability of multiple pharmacologic options for hereditary angioedema (HAE) and other forms of bradykinin-induced angioedema. Read More

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Practical Management of New-Onset Urticaria and Angioedema Presenting in Primary Care, Urgent Care, and the Emergency Department.

Eric Macy

Perm J 2021 11 22;25. Epub 2021 Nov 22.

Allergy Department, Southern California Permanente Medical Group, Kaiser Permanente Southern California, San Diego, CA.

A new episode of urticaria and/or angioedema can be an anxiety-inducing event for both the patient and the physician(s) seeing them in primary care, urgent care, or the emergency department. These events are commonly mistaken for "allergic" reactions and often mistreated. The most common causes of new onset urticaria in older children and adults, with or without angioedema, and normal vital signs or hypertension, are post-infection or acute idiopathic urticaria. Read More

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November 2021

Thiol-Disulfide Homeostasis in Skin Diseases.

J Clin Med 2022 Mar 9;11(6). Epub 2022 Mar 9.

Department of Dermatology, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.

Oxidative stress represents the imbalance between oxidants and antioxidants and has been associated with a wide range of diseases. Thiols are the most important compounds in antioxidant defense. There is an equilibrium between thiols and their oxidized forms, disulfides, known as dynamic thiol-disulfide homeostasis (TDH). Read More

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A systematic review on mucocutaneous presentations after COVID-19 vaccination and expert recommendations about vaccination of important immune-mediated dermatologic disorders.

Dermatol Ther 2022 Jun 11;35(6):e15461. Epub 2022 Apr 11.

Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

With dermatologic side effects being fairly prevalent following vaccination against COVID-19, and the multitude of studies aiming to report and analyze these adverse events, the need for an extensive investigation on previous studies seemed urgent, in order to provide a thorough body of information about these post-COVID-19 immunization mucocutaneous reactions. To achieve this goal, a comprehensive electronic search was performed through the international databases including Medline (PubMed), Scopus, Cochrane, Web of science, and Google scholar on July 12, 2021, and all articles regarding mucocutaneous manifestations and considerations after COVID-19 vaccine administration were retrieved using the following keywords: COVID-19 vaccine, dermatology considerations and mucocutaneous manifestations. A total of 917 records were retrieved and a final number of 180 articles were included in data extraction. Read More

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Toxic Epidermal Necrolysis associated with COVID-19 infection: A case report.

Clin Case Rep 2022 Mar 13;10(3):e05565. Epub 2022 Mar 13.

Department of Pediatrics Hamad Medical Corporation Doha Qatar.

Toxic Epidermal Necrolysis/Steven-Johnson Syndrome (TEN/SJS) is one of the most serious dermatological adverse reactions triggered mainly by drugs and less likely by infections. COVID-19 disease is caused by Sever Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) with a wide range of clinical manifestations. Skin involvement is common in COVID-19 patients including urticaria, purpura, and vasculitis. Read More

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Dermatological Manifestations of COVID-19 in Children.

Indian Pediatr 2022 05 10;59(5):393-399. Epub 2022 Mar 10.

Department of Dermatology, Amaltas Institute of Medical Sciences, Dewas, Madhya Pradesh.

Context: The clinical picture of pediatric severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection differs from adults as do the cutaneous manifestations. In this review, we summarize the varied morphological manifestations of SARS-CoV-2 infection in the pediatric population.

Evidence Acquisition: A comprehensive literature search was conducted (23 September, 2021) across multiple databases (PubMed, EMBASE, MEDLINE and Cochrane) with the relevant keywords. Read More

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Contribution of cyclooxygenase-1-dependent prostacyclin synthesis to bradykinin-induced dermal extravasation.

Biomed Pharmacother 2022 Apr 5;148:112786. Epub 2022 Mar 5.

Institute of Pharmacology and Clinical Pharmacology, Heinrich Heine University, Düsseldorf, Germany. Electronic address:

Background: Non-allergic angioedema is a potentially life-threatening condition caused by accumulation of bradykinin and subsequent activation of bradykinin type 2 receptors (B2). Since COX activity plays a pivotal role in B2 signaling, the aim of this study was to determine which prostaglandins are the key mediators and which COX, COX-1 or COX-2, is predominantly involved.

Methods: We used Miles assays to assess the effects of inhibitors of COX, 5-lipoxygenase, epoxyeicosatrienoic acid generation, cytosolic phospholipase Aα and a variety of prostaglandin receptor antagonists on bradykinin-induced dermal extravasation in C57BL/6 and COX-1-deficient mice (COX-1). Read More

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Repeated anaphylactic reaction after walking following an intraarticular injection of diclofenac etalhyaluronate sodium during a 3-day period.

Acute Med Surg 2022 Jan-Dec;9(1):e729. Epub 2022 Feb 16.

Department of Orthopedics, Shizuoka Hospital Juntendo University Izunokuni City Shizuoka Japan.

Background: There has been no English report of repeated anaphylactic reaction after exercise-induced anaphylaxis due to a single intraarticular injection of diclofenac etalhyaluronate sodium.

Case Presentation: A 60-year-old woman felt dyspnea, generalized itching, and urticaria following hypotension a few minutes after receiving an intraarticular injection of diclofenac etalhyaluronate sodium for the first time. She immediately received intramuscular adrenaline administration and her symptoms subsided. Read More

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February 2022

Drug-induced bowel complications and toxicities: imaging findings and pearls.

Abdom Radiol (NY) 2022 04 23;47(4):1298-1310. Epub 2022 Feb 23.

Department of Internal Medicine, Pratumtani Hospital, 7 Ladlumkaew Muang district, Pratumtani, 12000, Thailand.

The use of diverse types of drugs can result in a variety of acute and chronic complications that affect almost any organ. The bowel is one of the organs impacted by the side effects of medications. Imaging frequently plays a crucial role in the detection and characterization of complications occurring in the bowel. Read More

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