2,499 results match your criteria Urticaria Acute

On the binding reaction of loratadine with human serum acute phase protein alpha 1-acid glycoprotein.

J Biomol Struct Dyn 2021 Jun 14:1-8. Epub 2021 Jun 14.

Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India.

Loratadine is an important anti-allergic drug. It is a second generation antihistamine drug used to treat allergic rhinitis, hay fever and urticaria. Human serum alpha 1-acid glycoprotein (AG) is an important acute phase protein and its serum concentration is found to increase in inflammation and acute response. Read More

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Bullous eosinophilic annular erythema.

Dermatol Online J 2021 May 15;27(5). Epub 2021 May 15.

National Skin Centre.

Eosinophilic annular erythema is an idiopathic acute eosinophilic dermatosis. It is a rare condition, with approximately 30 cases reported in the English literature. It features annular, figurate urticarial edematous plaques primarily affecting the trunk and proximal limbs. Read More

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What's New in the Treatment of Urticaria and Angioedema.

J Allergy Clin Immunol Pract 2021 Jun;9(6):2170-2184

Department for Children and Adolescents, University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, Frankfurt, Germany.

Chronic urticaria and angioedema are diseases often managed by Allergy and Immunology specialists. Recent international guidelines have outlined a stepwise approach to management of patients using dose escalation of second-generation antihistamines followed by use of omalizumab and finally cyclosporine in more refractory cases. In select patients (those with refractory chronic urticaria), nonbiologic alternative medications with anti-inflammatory or immunosuppressant activity may be considered. Read More

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Knowledge, attitudes, and practices associated with personal health care on urticaria in peripheral health facilities of Yaoundé, Cameroon (Sub-Saharan Africa).

Int J Dermatol 2021 Jun 8. Epub 2021 Jun 8.

Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.

Background: Urticaria is an acute or chronic inflammatory dermatosis that is characterized by erythematous, edematous, itchy, and transient urticarial plaques that cover the skin and mucous membranes. The aim of this study was to evaluate the knowledge of consulting staff on urticaria in Yaoundé, Cameroon, as well as the attitudes and practices resulting from it.

Methods: We conducted a descriptive cross-sectional study. Read More

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Approach to Children with Hives.

Pediatr Ann 2021 May 1;50(5):e191-e197. Epub 2021 May 1.

Urticaria (or hives) is a pruritic and erythematous skin rash. Angioedema commonly occurs with urticaria. The term "chronic urticaria" is used when hives are present for more than 6 weeks. Read More

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Do Pediatric Emergency Physicians Comply With Guideline Recommendations in Management of Patients With Acute Urticaria?

Pediatr Emerg Care 2021 Jan 6. Epub 2021 Jan 6.

From the *Department of Pediatrics †Department of Pediatric Allergy and Immunology ‡Department of Pediatric Emergency, Istanbul Medeniyet University, Faculty of Medicine, Istanbul, Turkey.

Objectives: To determine the level of knowledge and practical preferences of pediatricians regarding acute urticaria (AU) management and to assess the effects of training provided in accordance with the current urticaria guideline recommendations on pediatricians who work in the pediatric emergency department (PED).

Methods: A theoretical training was provided to pediatricians regarding the diagnosis and treatment of AU in line with current urticaria guideline recommendations. Before the training, pediatricians completed a 10-item questionnaire. Read More

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January 2021

Remission of a case of multiple Hymenoptera stings-associated chronic urticaria during venom immunotherapy.

Clin Case Rep 2021 May 19;9(5):e04188. Epub 2021 May 19.

General Medicine, Immunology and Allergology Unit IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico Milan Italy.

Hymenoptera stings mostly cause acute urticaria but we describe a case of CU after wasp stings which remitted during venom immunotherapy. IgE-mechanisms have not been fully clarified in CU, except for isolated circumstances. In our case immunotherapy has played a positive role reducing immune cells reactivity and improving urticaria symptoms. Read More

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Dual biologic therapy in a patient with severe asthma and other allergic disorders.

BMJ Case Rep 2021 May 20;14(5). Epub 2021 May 20.

Section of Allergy/Immunology, Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana, USA

Severe asthma is very difficult to manage in many individuals, and systemic corticosteroids are often used to prevent or manage acute exacerbations. Furthermore, comorbid allergic conditions may render standard therapies inadequate. A 51-year-old man presented with severe eosinophilic asthma requiring nearly constant oral corticosteroid usage despite using high-dose inhaled corticosteroids and secondary asthma controllers. Read More

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Cutaneous Manifestations in the Context of SARS-CoV-2 Infection (COVID-19).

Actas Dermosifiliogr 2020 Nov 15;111(9):734-742. Epub 2020 Oct 15.

Servicio de Dermatología, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Barcelona, Spain.

The coronavirus 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has had enormous health, economic, and social consequences. The clinical spectrum of cutaneous manifestations observed in patients with COVID-19 is both heterogeneous and complex. To date, reports have identified 5 main categories: acral lesions, vesicular rashes, urticarial rashes, maculopapular rashes, and livedoid and necrotic lesions. Read More

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November 2020

[Medicaments and oral healthcare. Medicaments potentially inducing angioedema and/or urticaria].

Ned Tijdschr Tandheelkd 2021 May;128(5):269-276

Angioedema stems from increased vasodilation and vascular permeability, resulting in extravasation of fluid. Hereditary and acquired types of angioedema can be distinguished, with 3 and 4 subtypes, respectively. Groups of medicaments potentially inducing angioedema are, among others: ACE inhibitors, angiotensin II receptor blockers, dipeptidyl peptidase-4 inhibitors, thrombocyte aggregation inhibitors and immunosuppressive agents. Read More

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Genetic Variants in Cytosolic Phospholipase A2 Associated With Nonsteroidal Anti-Inflammatory Drug-Induced Acute Urticaria/Angioedema.

Front Pharmacol 2021 30;12:667824. Epub 2021 Apr 30.

Allergy Research Group, Instituto De Investigación Biomédica De Málaga-IBIMA, Malaga, Spain.

Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the main triggers of drug hypersensitivity reactions, probably due to their high consumption worldwide. The most frequent type of NSAID hypersensitivity is NSAID cross-hypersensitivity, in which patients react to NSAIDs from different chemical groups in the absence of a specific immunological response. The underlying mechanism of NSAID cross-hypersensitivity has been linked to cyclooxygenase (COX)-1 inhibition causing an imbalance in the arachidonic acid pathway. Read More

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Dermatological opinions are imperative in ambulatory and acute care settings for pediatric skin disorders - HL-SkinPed.

Arch Pediatr 2021 Jul 14;28(5):417-421. Epub 2021 May 14.

Department of Dermatology, Regional University Hospital (CHRU), 5, rue du Morvan, 54500 Vandoeuvre-lès-Nancy, France. Electronic address:

Background: Children with skin disorders usually receive care from a pediatrician, despite their limited training in this discipline. The advice of a dermatologist is frequently requested.

Objectives: To estimate the degree of concordance in the diagnosis, treatment, advice, and recommended follow-up of skin disorders between pediatricians (in private practice or a pediatric emergency department [PED]) and a dermatologist. Read More

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Gemfibrozil-Induced Polyuria.

Eur J Case Rep Intern Med 2021 27;8(4):002546. Epub 2021 Apr 27.

Patient First Medical Center affiliated with Beaumont Hospital, Dearborn, Michigan USA.

Gemfibrozil is a lipid-regulating agent used mainly to treat patients with hypertriglyceridaemia, especially those at risk for acute pancreatitis. Like any other pharmacological agent, gemfibrozil has known adverse effects, mainly gastrointestinal, such as cholelithiasis, gallstones, elevated transaminase, and other non-specific symptoms including dyspepsia, nausea and vomiting. Other reported adverse reactions are dizziness and vertigo, myopathy and rhabdomyolysis, angioedema, urticaria and rash. Read More

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Clinical effects and factors associated with adverse clinical outcomes of hymenopteran stings treated in a Thai Poison Centre: a retrospective cross-sectional study.

Clin Toxicol (Phila) 2021 May 7:1-7. Epub 2021 May 7.

Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Objective: To describe clinical effects and outcomes of hymenopteran stings and to explore the non-laboratory factors associated with adverse clinical outcomes, a composite outcome including death, respiratory failure requiring intubation, acute kidney injury (AKI) requiring dialysis and hypotension requiring vasopressor use.

Methods: A retrospective cross-sectional study was performed at the Ramathibodi Poison Center, a poison centre of a tertiary care hospital in Thailand. All cases of hymenopteran sting consultations from January 2015 to June 2019 were consecutively enrolled, and charts were reviewed. Read More

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Polymorphisms in eicosanoid-related biosynthesis enzymes associated with acute urticaria/angioedema induced by nonsteroidal anti-inflammatory drug hypersensitivity.

Br J Dermatol 2021 May 6. Epub 2021 May 6.

Allergy Research Group, Instituto de Investigación Biomédica de Málaga-IBIMA, ARADyAL, Malaga, Spain.

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs), probably the most consumed medicines, are the main triggers of drug hypersensitivity, being NSAID-induced acute urticaria/angioedema (NIUA) the most frequent phenotype. NSAID-hypersensitivity is bred by cyclooxygenase (COX)-1 inhibition, which leads to an imbalance in prostaglandin (PG) and cysteinyl-leukotriene (CysLT) synthesis. As only susceptible individuals develop NSAID-hypersensitivity, genetic factors are believed to participate; however, no study has assessed the overall genetic variability of key enzymes in PG and CysLT synthesis in NSAID-hypersensitivity. Read More

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A Unique Set of Symptoms in the Background of SARS-CoV-2 Infection.

Cureus 2021 Apr 1;13(4):e14244. Epub 2021 Apr 1.

Internal Medicine, National University of Medical Sciences, Rawalpindi, PAK.

Coronavirus disease 2019 (COVID-19) is a respiratory disease that has been reported to have a wide array of extrapulmonary manifestations. Our knowledge regarding this virus is constantly evolving, and new literature is being published every day. Children usually have a mild severity of COVID-19 infection. Read More

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Acute urticaria in children: from pediatric emergency department to allergology consultation at a central hospital.

Eur Ann Allergy Clin Immunol 2021 May 4. Epub 2021 May 4.

Medical doctor, Allergy Department, Centro Hospitalar Vila Nova de Gaia/Espinho, EPE, Vila Nova de Gaia, Portugal.

Summary: Acute urticaria is a common condition in the pediatric emergency department (ED) and no data is available in Portugal. We aimed to characterize the prevalence, etiology and management of acute urticaria in children presenting at an ED of a portuguese central hospital and report the follow-up investigation when drug or food allergy was suspected. Retrospective study of clinical records from children admitted to the ED with acute urticaria during one year period. Read More

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Pleomorphicskin eruptions in a COVID-19 affected patient: Case report and review of the literature.

Immun Inflamm Dis 2021 May 4. Epub 2021 May 4.

Covid Unit, Istituto Dermopatico dell'Immacolata-IRCCS, FLMM, Rome, Italy.

The coronavirus disease (COVID-19), during its course, may involve several organs, including the skin with a petechial skin rash, urticaria and erythematous rash, or varicella-like eruption, representing an additional effect of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, as commonly observed in other viral diseases. Considering that symptomatic patients with COVID-19 generally undergo multidrug treatments, the occurrence of a possible adverse drug reaction presenting with cutaneous manifestations should be contemplated. Pleomorphic skin eruptions occurred in a 59-year-old Caucasian woman, affected by a stable form of chronic lymphocytic leukemia, and symptomatic SARS-CoV-2 infection, treated with a combination of hydroxychloroquine sulfate, darunavir, ritonavir, sarilumb, omeprazole, ceftriaxone, high-flow oxygen therapy devices, filgrastim (Zarzio®) as a single injection, and enoxaparin. Read More

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Risk Factors for Acute Urticaria in Central California.

Int J Environ Res Public Health 2021 04 2;18(7). Epub 2021 Apr 2.

Department of Public Health and Central Valley Health Policy Institute, College of Health and Human Services, California State University, Fresno, CA 93740, USA.

At least 15-20% of the population in the world suffers from urticaria. Allergy triggers contribute to the development of urticaria. Not much is known about the demographic and environmental risk factors that contribute to the occurrence of acute urticaria. Read More

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Advanced Biomarkers: Therapeutic and Diagnostic Targets in Urticaria.

Int Arch Allergy Immunol 2021 Apr 29:1-15. Epub 2021 Apr 29.

Department of Dermatology, The Third Xiangya Hospital, Central South University, Changsha, China.

Urticaria is a type of skin disease characterized by rapid onset of hives (superficial dermis edema, erythema, pruritus, or burning sensation). According to whether the natural course exceeds 6 weeks, urticaria can be divided into acute and chronic urticaria (CU). At present, the evaluation of CU activity mainly depends on the Urticaria Activity Score (UAS), but the evaluation indicators are relatively single, and we need more reliable experimental data for evaluation. Read More

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Cutaneous Manifestations of COVID-19.

Cutis 2021 Feb;107(2):90-94

Ms. Schwartzberg is from the New York Institute of Technology College of Osteopathic Medicine, Old Westbury. Dr. Lin is from the Department of Dermatology, St. John's Episcopal Hospital, Far Rockaway, New York. Dr. Jorizzo is from the Department of Dermatology, Wake Forest Baptist Health, Winston-Salem, North Carolina, and Weill Cornell Medicine Dermatology, New York, New York.

Patients with coronavirus disease 2019 (COVID-19) present with multisystem signs and symptoms, including dermatologic manifestations. The recent literature has revealed that dermatologic manifestations of COVID-19 often are early onset and provide helpful cues to a timely diagnosis. We compiled the relevant emerging literature regarding the dermatologic manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) so that physicians can be aware of the various clinical cutaneous presentations in this time of high incidence of COVID-19. Read More

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February 2021

What's Eating You? Black Butterfly (Hylesia nigricans).

Cutis 2021 Feb;107(2):68-70

Dr. González is from the Dermatology Service, Kennedy Hospital, Bogotá, Colombia. Dr. Sandoval is from the Dermatology Program, El Bosque University, Bogotá. Drs. Motta and Rolón are from Simón Bolívar Hospital, Bogotá. Dr. Motta is from the Dermatology Service, and Dr. Rolón is from the Dermatopathology Service.

Lepidopterism refers to the adverse medical effects of contact with insects of the order Lepidoptera, which includes both moths and butterflies. These effects typically result from contact with an insect during the caterpillar (larval) stage. Lepidopterism involves multiple pathologic mechanisms, including direct toxicity of venom and mechanical irritant effects. Read More

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February 2021

The Use of Bruton's Tyrosine Kinase Inhibitors to Treat Allergic Disorders.

Curr Treat Options Allergy 2021 Apr 16:1-13. Epub 2021 Apr 16.

Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD USA.

Purpose Of Review: Studies show that inhibitors of Bruton's tyrosine kinase (BTKis), currently FDA-approved for the treatment of B cell malignancies, can prevent IgE-mediated reactions through broad inhibition of the FcεRI signaling pathway in human mast cells and basophils. This review will summarize recent data supporting the use of these drugs as novel therapies in various allergic disorders.

Recent Findings: Recent studies have shown that BTKis can prevent IgE-mediated degranulation and cytokine production in primary human mast cells and basophils. Read More

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COVID-19 vaccination of patients with allergies and type-2 inflammation with concurrent antibody therapy (biologicals) - A Position Paper of the German Society of Allergology and Clinical Immunology (DGAKI) and the German Society for Applied Allergology (AeDA).

Allergol Select 2021 1;5:140-147. Epub 2021 Apr 1.

Allergology and Immunology, Department of Dermatotology, Venereology and Allergology, Charité Universitätsmedizin Berlin, Germany.

Background: After the beginning and during the worldwide pandemic caused by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2), patients with allergic and atopic diseases have felt and still feel insecure. Currently, four vaccines against SARS-CoV-2 have been approved by the Paul Ehrlich Institute in Germany, and vaccination campaigns have been started nationwide. In this respect, it is of utmost importance to give recommendations on possible immunological interactions and potential risks of immunomodulatory substances (monoclonal antibodies, biologicals) during concurrent vaccination with the approved vaccines. Read More

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Viral Infections and Cutaneous Drug-Related Eruptions.

Front Pharmacol 2020 10;11:586407. Epub 2021 Mar 10.

Pediatric Allergy Unit, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland.

In the general population, up to 10% of children treated by antibiotics have cutaneous adverse drug reaction, but allergy is confirmed in less than 20% of patients. Most of the non-allergic reactions are probably due to virus, such as enterovirus acute infection or Ebstein-Barr Virus (EBV) acute infection or reactivation. Especially in children, viruses have the propensity to induce skin lesions (maculopapular rash, urticaria) due to their skin infiltration or immunologic response. Read More

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Metamizole-Induced Type I Kounis Syndrome.

Eur J Case Rep Intern Med 2021 8;8(3):002249. Epub 2021 Feb 8.

Department of Internal Medicine, Hospital Professor Doutor Fernando Fonseca EPE, Amadora, Portugal.

Kounis syndrome (KS) is defined as acute coronary syndrome (ACS) triggered by mast cell and platelet activation in the setting of allergic or anaphylactic insults. KS is a unique and complex cause of ACS and many cases may be missed due to its highly variable clinical manifestations. In this report, we present a case of KS type I triggered by metamizole in the absence of a previous history of allergy to this drug. Read More

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February 2021

Unnecessary Abdominal Surgeries in Attacks of Hereditary Angioedema with Normal C1 Inhibitor.

Clin Rev Allergy Immunol 2021 Mar 23. Epub 2021 Mar 23.

Faculdade de Medicina, Centro Universitario Saude ABC, Santo Andre, Sao Paulo, SP, Brazil.

Hereditary angioedema (HAE) is an autosomal dominant disease mostly due to the deficiency of C1 inhibitor (C1-INH). HAE with normal C1-INH was first described in 2000 and associated with mutations in the coagulation factor XII in 2006. Both diseases are associated with high bradykinin production, resulting in increased vascular permeability. Read More

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[Recommendations for the diagnosis and treatment of urticaria in children].


Arch Argent Pediatr 2021 04;119(2):S54-S66

Urticaria is one of the most common skin disorders in children. We define acute urticaria when it persists for less than 6 weeks, and chronic urticaria (CU), when it persists longer. Urticaria affects 25 % of the population; in most cases, it is acute urticaria. Read More

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Acute urticaria as the initial presentation of COVID-19 in a pediatric patient.

JAAD Case Rep 2021 May 16;11:137-138. Epub 2021 Mar 16.

Division of Allergy and Immunology, Children's National Hospital, Washington, District of Columbia.

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