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    Off-label-use of sulfur-hexafluoride in voiding urosonography for diagnosis of vesicoureteral reflux in children: A survey on adverse events.
    World J Clin Pediatr 2017 Feb 8;6(1):52-59. Epub 2017 Feb 8.
    Alexander Sauer, Clemens Wirth, Section of Pediatric Radiology, Department of Diagnostic and Interventional Radiology, University Hospital Wuerzburg, 97080 Wuerzburg, Germany.
    Aim: To evaluate the risk profile of sulfur hexafluoride in voiding urosonography (VUS) based on a large cohort of children.

    Methods: Since 2011 sulfur hexafluoride (SH, SonoVue(®), Bracco, Italy) is the only ultrasound contrast available in the European Union and its use in children has not been approved. Within a 4-year-period, 531 children with suspected or proven vesicoureteral reflux (f/m = 478/53; mean age 4. Read More

    Food Protein-Induced Enterocolitis Syndrome.
    J Investig Allergol Clin Immunol 2017 ;27(1):1-18
    Unidade de Alergia e Imunologia do Instituto da Criança, HC Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
    Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-, cell-mediated food allergy of unknown prevalence and pathophysiology. Onset is typically during the first year of life; seafood-induced FPIES may start in adulthood. Acute FPIES manifests within 1-4 hours after ingestion with repetitive emesis, pallor, and lethargy progressing to dehydration and hypovolemic shock in 15% of cases. Read More

    Aspirin Desensitization in Patients With Coronary Artery Disease: Results of the Multicenter ADAPTED Registry (Aspirin Desensitization in Patients With Coronary Artery Disease).
    Circ Cardiovasc Interv 2017 Feb;10(2)
    From the Dipartimento Cardiovascolare, ASST Papa Giovanni XXIII, Bergamo, Italy (R.R., A.I., G.M., M.S.); Division of Cardiology, A.O.U San Luigi Gonzaga, Orbassano, Torino, Italy (R.P., M.B.); IRCCS Fondazione Policlinico S. Matteo, Pavia, Italy (S.L.); Divisione di Cardiologia, Ospedale Carlo Poma, Mantova, Italy (C.L.); Cardiologia 1 Emodinamica, Dipartimento Cardiovascolare, ASST Niguarda Grande Ospedale Metropolitano, Milano, Italy (I.B., P.C.); U.O. Emodinamica, Ospedale Sandro Pertini, Roma, Italy (S.R.); Università degli Studi di Pavia, Italy (C.D.); Unità operativa di Cardiologia, Humanitas Mater Domini, Castellanza (Varese), Italy (A.A.); Cardio-Thoracic-Vascular Department, Ferrarotto Hospital, University of Catania, Italy (D.C.); and Division of Cardiology, University of Florida College of Medicine, Jacksonville (D.J.A.).
    Background: There are limited data on aspirin (ASA) desensitization for patients with coronary artery disease. The aim of the present study was to assess the safety and efficacy of a standard rapid desensitization protocol in patients with ASA sensitivity undergoing coronary angiography.

    Methods And Results: This is a prospective, multicenter, observational study including 7 Italian centers including patients with a history of ASA sensitivity undergoing coronary angiography with intent to undergo percutaneous coronary intervention. Read More

    Anaphylaxis in a 4-year-old male caused by contact with grasses: a case report.
    World Allergy Organ J 2017 19;10(1). Epub 2017 Jan 19.
    Universidad de Especialidades Espíritu Santo, School of Medicine, Samborondón, Ecuador ; Respiralab, Respiralab Research Group, Guayaquil, Ecuador.
    Background: Acute urticaria is the presence of urticaria for <6 weeks, and it is the most common type of urticaria in children. Sometimes, it may be associated with anaphylaxis, a life-threatening condition. Urticaria must be differentiated from anaphylaxis because the latter may require emergency treatment. Read More

    Acute reactions to polysulfone/polyethersulfone dialysers: literature review and management.
    Neth J Med 2017 Jan;75(1):4-13
    Department of Nephrology, University Medical Center, Utrecht, the Netherlands.
    Acute dialyser reactions in patients treated by haemodialysis are uncommon. We present two cases of such reactions, both in patients using a polysulfone, steam-sterilised dialyser. Patient 1 suffered from recurrent attacks of acute dyspnoea, hypoxia and hypotension that occurred early in dialysis sessions, whereas patient 2 presented with unexplained episodes of severe hypotension and vomiting in the initial phases of dialysis. Read More

    High-dose anti-histamine use and risk factors in children with urticaria.
    Turk Pediatri Ars 2016 Dec 1;51(4):198-203. Epub 2016 Dec 1.
    Division of Pediatric Allergy and Clinical Immunology, Adnan Menderes University School of Medicine, Aydın, Turkey.
    Aim: The drugs of choice in the treatment of urticaria in children are H1-antihistamines. The aim of the study was to evaluate children with urticaria and define risk factors for requirement of high-dose H1-antihistamines in children with urticaria.

    Material And Methods: The medical data of children who were diagnosed as having urticaria admitted to our outpatient clinic between January 2014 and January 2016 were searched. Read More

    Late Onset of Acute Urticaria after Bee Stings.
    Case Rep Dermatol 2016 Sep-Dec;8(3):341-343. Epub 2016 Dec 1.
    Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Japan.
    Here we report the cases of five patients with a late onset of acute urticaria after a bee sting. The ages of the five Japanese patients ranged from 33 to 86 years (median: 61). All patients had no history of an allergic reaction to bee stings. Read More

    IgE-Related Chronic Diseases and Anti-IgE-Based Treatments.
    J Immunol Res 2016 21;2016:8163803. Epub 2016 Dec 21.
    Biochemistry Unit, Biomedicine Department, Faculty of Medicine, University of Barcelona, Casanova 143, 08036 Barcelona, Spain.
    IgE is an immunoglobulin that plays a central role in acute allergic reactions and chronic inflammatory allergic diseases. The development of a drug able to neutralize this antibody represents a breakthrough in the treatment of inflammatory pathologies with a probable allergic basis. This review focuses on IgE-related chronic diseases, such as allergic asthma and chronic urticaria (CU), and on the role of the anti-IgE monoclonal antibody, omalizumab, in their treatment. Read More

    Analysis of primary treatment and prognosis of spontaneous urticaria.
    Allergol Int 2017 Jan 13. Epub 2017 Jan 13.
    Department of Dermatology, Integrated Health Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
    Background: The prognosis of spontaneous urticaria in association with early treatment remains unclear. In this study, we retrospectively studied the prognosis of acute spontaneous urticaria in relation to age and treatments in a local clinic of dermatology.

    Methods: Out of 5000 patients who visited an office dermatology clinic, clinical records of patients with spontaneous urticaria were extracted. Read More

    Cutaneous exposure to vesicant phosgene oxime: Acute effects on the skin and systemic toxicity.
    Toxicol Appl Pharmacol 2017 Feb 11;317:25-32. Epub 2017 Jan 11.
    Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
    Phosgene Oxime (CX), an urticant or nettle agent categorized as a vesicant, is a potential chemical warfare and terrorist weapon. Its exposure can result in widespread and devastating effects including high mortality due to its fast penetration and ability to cause immediate severe cutaneous injury. It is one of the least studied chemical warfare agents with no effective therapy available. Read More

    Current and future therapies for the treatment of histamine-induced angioedema.
    Expert Opin Pharmacother 2017 Feb 25;18(3):253-262. Epub 2017 Jan 25.
    a Department of Internal Medicine, Division of Immunology, Rheumatology, and Allergy , University of Cincinnati College of Medicine , Cincinnati , Ohio , USA.
    Introduction: Angioedema, a sudden, self-limited swelling of localized areas of any part of the body that may or may not be associated with urticaria, is thought to be the result of a mast-cell mediated process versus a bradykinin etiology. Understanding the mechanism is key in determining the proper treatment. Areas Covered: Clinical presentation of varying angioedema types may be similar; however, the appropriate treatment algorithm is dependent upon clinicians' knowledge of the underlying pathophysiology and classification of angioedema. Read More

    Involvement of microRNAs in skin disorders: A literature review.
    Allergy Asthma Proc 2017 Jan;38(1):9-15
    Background: miRNAs are a class of noncoding RNA molecules that modulate gene expression after transcription. It is known that miRNAs are involved in various cellular processes of both normal and diseased skin. Recently, differential expressions of miRNAs have been reported and associated with several immunologic and inflammatory disorders, which indicate a common role in fundamental biologic processes. Read More

    [Acute respiratory viral infections: Topical issues of diagnosis, prevention and treatment in therapeutic practice].
    Ter Arkh 2016 ;88(11):76-82
    Omsk City Clinical Hospital #1, Omsk, Russia.
    Aim: to assess the efficacy and safety of the medication Grippferon with loratadine for the prevention of acute respiratory viral infections (ARVI) and influenza during the epidemics.

    Material And Methods: This study included 103 patients (67 men and 36 women) aged 18 to 52 years (mean age 35.3±3. Read More

    Is this a simple drug eruption to be discharged?
    Turk J Emerg Med 2016 Dec 14;16(4):176-178. Epub 2016 Jun 14.
    Ataturk University Education and Research Hospital, Department of Emergency Medicine, Erzurum, Turkey.
    'Erythema Multiforme associated with Phenytoin And Cranial radiation Therapy' (EMPACT) is a very rare clinic situation and classified in EM-like drug reactions. It can be easily misdiagnosed as acute urticaria or drug eruption in ED. Initial symptoms may resemble a simple skin problem, but diagnosing and early hospitalization of the patients can be lifesaving. Read More

    Antiepilepsy drugs and the immune system.
    Ann Allergy Asthma Immunol 2016 Dec;117(6):634-640
    Allergy/Immunology Section, Louisiana State University Health Sciences Center, Shreveport, Louisiana. Electronic address:
    Objective: To alert physicians about the peculiar adverse effects of antiepilepsy drugs (AEDs) on the immune system.

    Data Sources: PubMed literature during the past 25 years.

    Study Selections: Reports and review articles on the hypersensitivities of AEDs and their effect on immunity. Read More

    First Report on Infant Acute Urticaria after Mother's Parenteral Use of Meglumine Antimoniate (Glucantime): A Case Report.
    Iran J Public Health 2016 Sep;45(9):1217-1219
    Traditional and Complementary Medicine Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
    Pentavalent antimonials are still the first drug of choice for the treatment of cutaneous leishmaniasis (CL). Like other treatments, they can cause adverse reactions including musculoskeletal pain, gastrointestinal disturbances, and mild to moderate headaches. In this paper, we report the first case of an infant who developed acute urticaria after her mother's parenteral use of meglumine antimoniate (glucantime). Read More

    Subcutaneous administration of human C1 inhibitor with recombinant human hyaluronidase in patients with hereditary angioedema.
    Allergy Asthma Proc 2016 Nov;37(6):489-500
    Division of Rheumatology, Allergy and Immunology, US HAEA Angioedema Center, University of CaliforniaSan Diego School of Medicine, La Jolla, California, USA.
    Background: The currently approved method of C1 inhibitor (C1 INH) administration for patients with hereditary angioedema with C1 INH deficiency (HAE) is by intravenous injection. A C1 INH subcutaneous formulation may provide an attractive mode of administration for some patients.

    Objective: To evaluate efficacy and safety of two doses of subcutaneous, plasma-derived C1 INH with the dispersing agent, recombinant human hyaluronidase (rHuPH20) to prevent angioedema attacks in patients with HAE. Read More

    Investigation of thiol-disulphide balance in patients with acute urticaria and chronic spontaneous urticaria.
    Cutan Ocul Toxicol 2017 Jan 18:1-6. Epub 2017 Jan 18.
    c Department of Biochemistry , Ministry of Health Atatürk Training and Research Hospital , Ankara , Turkey.
    Background: Thiol-disulphide balance plays a major role in health and diseases. This balance may be disrupted by various diseases. We aimed to determine status of the effect of thiol-disulphide balance in urticaria. Read More

    Cutaneous Manifestation of Food Allergy.
    Immunol Allergy Clin North Am 2017 Feb 28;37(1):217-231. Epub 2016 Oct 28.
    Division of Clinical Immunology and Allergy, Department of Pediatrics, Children's Hospital Los Angeles, 4650 Sunset Boulevard MS#75, Los Angeles, CA 90027, USA. Electronic address:
    Hypersensitivity reactions to foods can have diverse and highly variable manifestations. Cutaneous reactions, such as acute urticaria and angioedema, are among the most common manifestations of food allergy. However, cutaneous manifestations of food allergy encompass more than just IgE-mediated processes and include atopic dermatitis, contact dermatitis, and even dermatitis herpetiformis. Read More

    Differential Diagnosis of Chronic Urticaria and Angioedema Based on Molecular Biology, Pharmacology, and Proteomics.
    Immunol Allergy Clin North Am 2017 Feb 28;37(1):201-215. Epub 2016 Oct 28.
    Yale School of Medicine, Gesher LLC, Allergy, Asthma and Clinical Immunology, 4 Clifton Avenue, Waterbury CT 06710, USA. Electronic address:
    Differential diagnosis of urticaria and angioedema has been based on the phenotype as either acute or chronic depending on the duration of more than 6 to 8 weeks, respectively. Additional subdivisions include poorly defined terms such as idiopathic, spontaneous, or autoimmune. In this article, the author suggests that an increased understanding of the acquired and innate immune system and data from novel proteomic technology have blurred the lines between these categories of diagnosis. Read More

    Hereditary angioedema (HAE): a cause for recurrent abdominal pain.
    BMJ Case Rep 2016 Nov 14;2016. Epub 2016 Nov 14.
    Department of Cardiology, Maimonides Medical Center, Brooklyn, New York, USA.
    A 44-year-old Hispanic woman presented to the emergency room with a 2-day history of sudden onset of severe cramping left lower quadrant abdominal pain associated with ∼20 episodes diarrhoea. Abdominal CT scan exhibited bowel wall oedema and acute extensive colitis. On the basis of the preliminary diagnosis of acute abdomen, the patient was admitted under the surgical team and treated for acute colitis. Read More

    Urticaria: "You're Probably Just Allergic to Something".
    Pediatr Ann 2016 Nov;45(11):e399-e402
    Urticaria is a common symptom seen in pediatric patients, and it has multiple allergic and nonallergic causes. Unfortunately, it is far too common that when children present acutely for urticaria, they are told that it is an "allergy." This statement often leads to increased anxiety while the patient waits to be evaluated by an allergist/immunologist. Read More

    Vibrational angioedema: considerations for oral health care providers.
    Spec Care Dentist 2016 Nov 26;36(6):335-338. Epub 2016 Apr 26.
    Associate Professor, Department of Oral Medicine, University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania..
    Vibratory angioedema (VA) is a rare, inherited type of physical urticaria characterized by acute onset of mucosal and / or cutaneous edema that is triggered by vibration. We report a case of a 63-year-old woman with VA elicited by use of mechanized (vibratory) dental equipment. To our knowledge, this is the first report of VA induced by mechanical dental equipment. Read More

    Lower serum B12 vitamin concentrations are not accompanied by hyperhomocysteinaemia in chronic spontaneous urticaria.
    Clin Exp Dermatol 2017 Jan 16;42(1):36-40. Epub 2016 Oct 16.
    Medical Center, Zabrze, Poland.
    Background: Lower serum vitamin B12 concentrations have been observed in patients with chronic spontaneous urticaria (CSU). It is known that vitamin B12 deficiency is closely related to hyperhomocysteinaemia, which is associated with a proinflammatory state.

    Aim: To assess the relationship between vitamin B12 status and concentrations of homocysteine (Hcy) with acute phase response in patients with CSU. Read More

    Systemic Allergy to Corticosteroids: Clinical Features and Cross Reactivity.
    Curr Pharm Des 2016 ;22(45):6825-6831
    Dermatology and Allergy Department, rue de la Chine, Paris, F-75020, France.
    Systemic hypersensitivity (HS) to corticosteroids (CS) is paradoxical but does exist. Some patients with a previous contact allergy to topical CS may develop a systemic contact dermatitis (SCD) while receiving CS orally or intravenously. However, a previous contact sensitization is not mandatory for developing a systemic HS to CS. Read More

    Clinical approach on challenge and desensitization procedures with aspirin in patients with ischemic heart disease and nonsteroidal anti-inflammatory drug hypersensitivity.
    Allergy 2017 Mar 28;72(3):498-506. Epub 2016 Nov 28.
    Cardiology Unit, Azienda Sanitaria Romagna, Rimini Hospital, Rimini, Italy.
    Background: Hypersensitivity to acetylsalicylic acid (ASA) constitutes a serious problem for subjects with coronary artery disease. In such subjects, physicians have to choose the more appropriate procedure between challenge and desensitization. As the literature on this issue is sparse, this study aimed to establish in these subjects clinical criteria for eligibility for an ASA challenge and/or desensitization. Read More

    Pathogenesis of Aspirin-Induced Reactions in Aspirin-Exacerbated Respiratory Disease.
    Immunol Allergy Clin North Am 2016 Nov 13;36(4):681-691. Epub 2016 Sep 13.
    Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, 1 Jimmy Fund Way, Smith Building, Room 638, Boston, MA 02115, USA. Electronic address:
    The acute clinical symptoms that develop following the oral ingestion of aspirin, or any other inhibitor of cyclooxygenase-1, are well established in aspirin-exacerbated respiratory disease: nasal congestion, rhinorrhea, and bronchospasm. Less commonly, gastrointestinal distress, rash, angioedema, or urticaria also develops. However, the pathobiology that drives these clinical reactions is poorly understood. Read More

    Clinical practice guideline for diagnosis and management of urticaria.
    Asian Pac J Allergy Immunol 2016 Sep;34(3):190-200
    Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Chulalongkorn University, Bangkok, Thailand.
    Urticaria is a common skin condition that can compromise quality of life and may affect individual performance at work or school. Remission is common in majority of patients with acute spontaneous urticaria (ASU); however, in chronic cases, less than 50% had remission. Angioedema either alone or with urticaria is associated with a much lower remission rate. Read More

    The clinical and laboratory characteristics of acute spontaneous urticaria and its progression to chronic spontaneous urticaria.
    Allergy Asthma Proc 2016 Sep;37(5):394-9
    Leumit Health Services, Ashdod, Israel.
    Background: The natural history of the progression from acute spontaneous urticaria (ASU) to chronic spontaneous urticaria (CSU), CSU remains poorly understood.

    Objective: To identify clinical and laboratory patient attributes that may be predictive of ASU progression to CSU.

    Methods: We prospectively studied consecutive adult patients (age ≥ 18 years) with a diagnosis of urticaria of <6 weeks' duration. Read More

    Skin disease and thyroid autoimmunity in atopic South Italian children.
    World J Clin Pediatr 2016 Aug 8;5(3):288-92. Epub 2016 Aug 8.
    Marcella Pedullà, Vincenzo Fierro, Pierluigi Marzuillo, Francesco Capuano, Emanuele Miraglia del Giudice, Department of Woman, Child and General and Specialized Surgery, Seconda Università degli Studi di Napoli, 80138 Napoli, Italy.
    Aim: To verify the prevalence of thyroid autoimmunity (TA) and the possible association between atopy and TA in children affected by skin disease.

    Methods: Three hundred and twenty-four children consecutively referred due to skin disease symptoms to our Pediatric Department were enrolled. One hundred and eighty-seven were diagnosed with atopic dermatitis (AD), 95 with acute urticaria, 40 with chronic urticaria (CU), and 2 with alopecia areata (AA). Read More

    Itch in Urticaria Management.
    Curr Probl Dermatol 2016 23;50:77-85. Epub 2016 Aug 23.
    Urticaria is a common skin disorder defined by the occurrence of itchy and even painful wheals, angioedema, or both. The lifetime prevalence for its acute and chronic form is 20 and 1%, respectively. The patients' quality of life is impaired because of itch, disfigurement, and high associated comorbidity. Read More

    A nationwide study of acquired C1-inhibitor deficiency in France: Characteristics and treatment responses in 92 patients.
    Medicine (Baltimore) 2016 Aug;95(33):e4363
    aInternal Medicine Department, Saint Antoine Hospital, Assistance Publique-Hôpitaux de Paris, DHU i2B, Paris 6 University, Paris bHematology Department, Pitié Salpétrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris 6 University, Paris cImmunology Laboratory, University Hospital, Grenoble dCentre de Référence et d'Etude des Angioedèmes à Kinine (CREAK) , Grenoble ePublic Health Department, Tenon Hospital, Assistance Publique-Hôpitaux de Paris, Paris 6 University fImmunology Laboratory, Georges Pompidou European Hospital, Assistance Publique-Hôpitaux de Paris, Paris 5 University, Paris gJoint Unit 1036 CNRS-CEA-INSERM, University Grenoble Alpes hInternal Medicine Department, University Hospital, Grenoble iUniversité Joseph Fourier Grenoble, GREPI/AGIM CNRS FRE 3405, Grenoble jInternal Medicine Department, La Conception Hospital, AP-HM, Marseille kInternal Medicine and Clinical Immunology Department, Lille University Hospital lLIRIC, INSERM UMR 995, EA2686, Lille mDermatology Department, L'UNAM Université, University Hospital, Angers, France.
    Acquired angioedema (AAE) due to C1-inhibitor (C1INH) deficiency is rare. Treatment options for acute attacks are variable and used off-label. Successful treatment of the associated lymphoma with rituximab seems to prevent acute attacks in subjects with AAE. Read More

    The high prevalence of Encephalitozoon intestinalis in patients receiving chemotherapy and children with growth retardation and the validity of real-time PCR in its diagnosis.
    Turk J Med Sci 2016 Jun 23;46(4):1050-8. Epub 2016 Jun 23.
    Department of Parasitology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
    Background/aim: The aim of this study was to investigate the presence of Encephalitozoon intestinalis in different patient groups consisting of immunocompromised and immunocompetent individuals.

    Materials And Methods: The stool samples of 100 patients consisting of 25 patients receiving chemotherapy and with acute gastrointestinal complaints, 25 with bone marrow transplant and acute gastrointestinal complaints, 25 with urticaria, and 25 with growth retardation were included in the study. As control groups, 25 subjects without any chronic disease but with acute gastrointestinal complaints and 25 healthy volunteers, making a total of 50 subjects, were included in the study. Read More

    Renal disease in patients infected with hepatitis B virus.
    Trop Gastroenterol 2015 Oct-Dec;36(4):220-8
    Infection with hepatitis B virus (HBV) can result in hepatic diseases which may include an asymptomatic non-replicative carrier state, immunotolerant phase characterized by high DNA levels without significant hepatic injury, immune-reactive phase characterized by occurrence of chronic hepatitis and fibrosis in the liver, or complications like cirrhosis or hepatocellular carcinoma. Extrahepatic manifestations may also accompany HBV infection. These may include serum sickness syndrome, polyarthralgia, polyarthritis, dermatologic manifestations like pitted keratolysis, urticaria, purpura, oral lichen planus or Gianotti-Crosti syndrome-a childhood papular eruption. Read More

    Ex Vivo and In Vivo Mice Models to Study Blastocystis spp. Adhesion, Colonization and Pathology: Closer to Proving Koch's Postulates.
    PLoS One 2016 10;11(8):e0160458. Epub 2016 Aug 10.
    Laboratory of Molecular and Cellular Parasitology, Department of Microbiology and Immunology, National University of Singapore, 5 Science Drive 2, Singapore, 117545.
    Blastocystis spp. are widely prevalent extra cellular, non-motile anerobic protists that inhabit the gastrointestinal tract. Although Blastocystis spp. Read More

    A joint allergist/cardiologist classification for thienopyridines hypersensitivity reactions based on their symptomatic patterns and its impact on the management strategies.
    Int J Cardiol 2016 Nov 16;222:509-14. Epub 2016 Jul 16.
    Department of Cardiology, University of Patras Medical School, Patras, Achaia, Greece.
    The role and importance of thienopyridines such as ticlopidine, clopidogrel, and prasugrel is well-established for several indications, ranging from prevention of acute coronary syndromes to percutaneous coronary interventions, where the dual antiplatelet therapy represents the gold standard to avoid denovo coronary stenosis. However, there is a significant cohort of patients with coronary artery disease who may manifest hypersensitivity reactions to thienopyridines. The examination of the various case reports from medical literature leads to identify mainly four clinical patterns of hypersensitivity to thienopyridines which involves more frequently cutaneous, hematologic, and articular tissues, therefore the kind and predominance of clinical symptoms may determine a different clinical approach to overcome or neutralize thienopyridines hypersensitivity. Read More

    Serum vitamin D levels decrease in children with acute urticaria.
    Allergol Immunopathol (Madr) 2016 Nov - Dec;44(6):512-516. Epub 2016 Jul 28.
    Department of Pediatric Allergy, Baskent University Faculty of Medicine, Ankara, Turkey.
    Background: Acute urticaria is an immune-inflammatory disease, characterised by acute immune activation. There has been increasing evidence showing that vitamin D deficiency is associated with increased incidence and severity of immune-inflammatory disorders.

    Objective: The aim of this study was to evaluate serum vitamin D levels in acute urticaria. Read More

    Application value of laboratory indexes in the differential diagnosis of Henoch-Schoenlein purpura.
    Z Rheumatol 2016 Jul 21. Epub 2016 Jul 21.
    Hangzhou First People's Hospital, 310006, Hangzhou, China.
    Objective: The aim of this study was to explore the value of laboratory indexes in the differential diagnosis of Henoch-Schoenlein purpura (HSP).

    Methods: Patients with HSP hospitalized at the Children's Hospital of Zhejiang University School of Medicine between January 2010 and December 2014 were enrolled in this prospective study. In addition, septic patients with rash and patients with urticaria, simple hematuria, and acute appendicitis hospitalized during the same period were selected at random as differential diagnosis subjects, and healthy children were selected as normal controls. Read More

    Atopic Predilection among Kawasaki Disease Patients: A Cross-Sectional Study of 1,187,757 Teenagers.
    Int Arch Allergy Immunol 2016 21;170(2):92-6. Epub 2016 Jul 21.
    Department of Plastic and Reconstructive Surgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
    Background: Kawasaki disease (KD) is an acute, systemic vasculitis in children, with an etiology that is not completely understood. It is assumed that the development of KD is mediated by an immunologic response. Several reports from East Asia have found a higher prevalence of atopic diseases among patients with KD, but a large-scale study of a non-Asian population regarding this correlation is still lacking. Read More

    Conjunctival allergen provocation test : guidelines for daily practice.
    Allergy 2017 Jan 18;72(1):43-54. Epub 2016 Aug 18.
    Ophthalmology Unit, Department of Neuroscience, University of Padua, Padua, Italy.
    Conjunctival allergen provocation test (CAPT) reproduces the events occurring by instilling an allergen on the ocular surface. This paper is the compilation of a task force focussed on practical aspects of this technique based on the analysis of 131 papers. Main mechanisms involved are reviewed. Read More

    The Humanistic, Societal, and Pharmaco-economic Burden of Angioedema.
    Clin Rev Allergy Immunol 2016 Oct;51(2):230-9
    HAE Centre Denmark, Department of Dermatology and Allergy Centre, Odense University Hospital, 5000, Odense C, Denmark.
    Hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE) is a rare disorder characterized by intermittent and unpredictable episodes of swelling which cause disfigurement, disability, pain, or, in case of laryngeal swelling, risk of death. Historical factors, including the intermittent nature of the disorder, the lack of awareness of this ultra-rare condition amongst medical personnel, lack of specialist centers, and limited treatment options have contributed to under-diagnosis and under-treatment of the condition. Incorrect treatment of attacks has been common, even when medical help is sought. Read More

    H1-Antihistamine Premedication in NSAID-Associated Urticaria.
    J Allergy Clin Immunol Pract 2016 Nov - Dec;4(6):1205-1212. Epub 2016 Jun 30.
    Department of Dermatology and Allergy, University Hospital Würzburg, Würzburg, Germany.
    Background: Therapeutic options for pain management are restricted in patients with nonsteroidal anti-inflammatory drug (NSAID)-induced or NSAID-exacerbated urticaria because strong cyclooxygenase (COX)-I inhibiting NSAID cannot be used. Alternative NSAID such as weak COX-I inhibitors or selective COX-II inhibitors are sometimes not sufficiently effective or have potentially troublesome adverse effects.

    Objective: To date, prophylactic premedication with H1-antihistamines is rarely practiced in patients concurrently suffering from recurrent pain and NSAID-associated urticaria. Read More

    Efficacy and safety of omalizumab in paediatric age: an update of literature data.
    J Biol Regul Homeost Agents 2016 Apr-Jun;30(2):579-84
    General and Acute Paediatric Operative Unit, Policlinico-Vittorio-Emanuele University Hospital, University of Catania, Italy.
    Immunoglobulin E (IgE) was discovered in 1966 and was found responsible for immune defense against helminths, type I hypersensitivity and allergic diseases. IgE mediates allergic responses by binding to Fc receptors (the high affinity Fc-epsilon receptor I and the low affinity Fc-epsilon receptor II or CD23) expressed on tissue mast cells and blood basophils. This binding leads to degranulation and release of pro-inflammatory mediators. Read More

    The efficacy and adverse effects of dicobalt edetate in cyanide poisoning.
    Clin Toxicol (Phila) 2016 Sep 28;54(8):609-14. Epub 2016 Jun 28.
    c Wales College of Medicine, Cardiff University, University Hospital Llandough , Cardiff , UK.
    Introduction: Dicobalt edetate is one of a number of cobalt compounds that have been studied in the treatment of cyanide poisoning, their efficacy being based upon the fact that cyanide combines with cobalt to form relatively non-toxic complexes. Inorganic cobalt salts are quite toxic (cyanide and cobalt antagonise one another's toxicity) and complexes such as dicobalt edetate were studied with the aim of identifying compounds that were less acutely toxic, but which retained the antidotal properties of cobalt salts. The proprietary preparation, Kelocyanor™, contains free cobalt and glucose as well as dicobalt edetate. Read More

    Management of Pregnancy and Delivery in Patients With Hereditary Angioedema Due to C1 Inhibitor Deficiency.
    J Investig Allergol Clin Immunol 2016 ;26(3):161-7
    Allergy Department, Hospital Universitario La Paz, Madrid, Spain.
    Background And Objective: There is little information on pregnancy and delivery in patients with hereditary angioedema due to C1 inhibitor deficiency (C1INH-HAE). The aim of this study was to describe the effect of pregnancy and deliveries on symptoms of C1INH-HAE and review the need for and safety of treatments available during the study period.

    Methods: Retrospective review using a purpose-designed questionnaire of 61 C1INH-HAE patients from 5 hospitals specialized in the management of HAE in Spain. Read More

    Seasonal Exacerbation of Asthma Is Frequently Associated with Recurrent Episodes of Acute Urticaria.
    Int Arch Allergy Immunol 2016 31;169(4):263-6. Epub 2016 May 31.
    Division of Allergy and Clinical Immunology, Bnai Zion Medical Center, Technion, Haifa, Israel.
    Background: Asthma and urticaria are both partially mediated by an increased release of histamine from highly activated mast cells. They are pathophysiologically different, as mast cell degranulation in these 2 disorders results from different mechanisms.

    Objective: To assess the incidence of urticaria in patients with asthma, and of asthma in patients with chronic spontaneous urticaria (CSU). Read More

    Dermatologic emergencies in a tertiary hospital: A descriptive study.
    Actas Dermosifiliogr 2016 Oct 26;107(8):666-73. Epub 2016 May 26.
    Departamento de Dermatología, Hospital Universitario de Salamanca, Salamanca, España; Instituto de Biología Molecular y Celular del Cáncer (IBMCC), Centro de Investigación del Cáncer (CIC), Salamanca, España.
    Background And Objective: Dermatology in-house call is uncommon in the Spanish national health system. The objective of the present study was to define the groups of dermatologic diseases and conditions most frequently seen in the emergency department and to evaluate the need for dermatology in-house call in the training of medical residents.

    Material And Methods: We performed a descriptive study of all patients who attended the emergency department with a skin complaint during a 1-year period (June 2013 to May 2014) and were assessed by 9 dermatology residents. Read More

    Pharmacologic Therapies in Pulmonology and Allergy.
    Med Clin North Am 2016 Jul 20;100(4):851-68. Epub 2016 Apr 20.
    Division of Allergy and Infectious Diseases, University of Washington School of Medicine, Seattle, WA 98195, USA; Center for Allergy and Inflammation, UW Medicine at South Lake Union, 750 Republican Street, Box 358061, Seattle, WA 98109-4725, USA.
    Conditions such as chronic rhinitis, urticaria, angioedema, and asthma are frequently seen in clinics and hospitals, and there are a core group of medications that are often used to treat these conditions. Knowing the indications, optimal dosing, and side-effect profile of these medications can improve outcomes. Chronic rhinitis due to various causes is one of the most common reasons for primary care physician visits. Read More

    Association of atopic diseases and parvovirus B19 with acute lymphoblastic leukemia in childhood and adolescence in the northeast of Brazil.
    Int J Clin Oncol 2016 Oct 25;21(5):989-995. Epub 2016 May 25.
    Research Center for Allergy and Clinical Immunology, Federal University of Pernambuco, Av. Prof. Moraes Rêgo, s/n, University City, Recife, PE, CEP 50670-901, Brazil.
    Background: Several factors related to the immune system, such as a history of allergies and virus infections, may be associated with acute lymphoblastic leukemia (ALL). The purpose of this study was to analyze whether the presence of atopic diseases and previous infection with parvovirus B19 and Epstein-Barr virus (EBV) are associated with the development of ALL.

    Methods: This case-control study was performed in two tertiary hospitals located in northeastern Brazil. Read More

    Acute allergic angioedema of upper lip.
    J Conserv Dent 2016 May-Jun;19(3):285-8
    Department of Conservative Dentistry and Endodontics, Tamil Nadu Government Dental College and Hospital, Chennai, Tamil Nadu, India.
    Mishaps can occur during dental procedures, some owing to inattention to detail and others are totally unpredictable. They usually include anaphylaxis or allergic reactions to materials used for restorative purposes or drugs such as local anesthetics. A patient reported to our department with moderate dental fluorosis, and the treatment was planned with indirect composite veneering. Read More

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