25,164 results match your criteria Urticaria


Current and Future Approaches in Management of Chronic Spontaneous Urticaria Using Anti-IgE Antibodies.

Medicina (Kaunas) 2022 Jun 17;58(6). Epub 2022 Jun 17.

Dermatology Department, "Elias" University Emergency Hospital, 011461 Bucharest, Romania.

Chronic spontaneous urticaria (CSU) considerably alters patients' quality of life, often for extended periods, due to pruriginous skin lesions, impaired sleep, unexpected development of angioedema, and failure of conventional treatments in properly controlling signs and symptoms. Recent research focused on the development of new therapeutic agents with higher efficacy. Although the production of specific immunoglobulin E (IgE) antibodies against certain allergens is not a characteristic of the disease, treatment with omalizumab, a monoclonal anti-IgE antibody, proved efficient and safe in patients with moderate to severe chronic spontaneous urticaria uncontrolled by H1-antihistamines. Read More

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Immuno-Pathogenesis of Chronic Inflammatory Skin Diseases: Novel Molecular Targets and Biomarkers.

Life (Basel) 2022 Jun 15;12(6). Epub 2022 Jun 15.

Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, SA, Italy.

Chronic inflammation has a crucial pathogenetic role in many diseases, including cutaneous chronic inflammatory disorders, such as psoriasis, atopic dermatitis, hidradenitis suppurativa, and chronic urticaria [... Read More

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Management of allergic reactions and anaphylaxis in the emergency department.

Emerg Med Pract 2022 Jul 1;24(7):1-24. Epub 2022 Jul 1.

Associate Professor of Emergency Medicine, University of Virginia School of Medicine, Charlottesville, VA.

An acute allergic reaction is a rapid-onset, IgE-mediated hypersensitivity reaction. Although it is most commonly caused by food, insect stings, and medications, there are many additional causes. Symptoms can range from mild urticaria and swelling, to abdominal cramping, to respiratory collapse. Read More

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CAN SKIN BE A MARKER FOR INTERNAL MALIGNANCY? EVIDENCE FROM CLINICAL CASES.

Acta Clin Croat 2021 Dec;60(4):711-721

1Department of Dermatovenereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; 2School of Dental Medicine, University of Zagreb, Zagreb, Croatia; 3Unit of Dermatology and Venereology, Zabok General Hospital, Bračak/Zabok, Croatia; 4Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; 5Ljudevit Jurak Department of Pathology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.

Although there are many single case reports on paraneoplastic dermatoses in the literature, there are very rare articles containing multiple cases. A retrospective study was performed to examine paraneoplastic dermatoses and accompanying malignancies based on skin manifestations and appropriate diagnostic evaluations. We recorded outcomes, current conditions, and surgical/oncologic treatments. Read More

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December 2021

Hoagland sign: bilateral upper eyelid oedema.

BMJ Case Rep 2022 Jun 22;15(6). Epub 2022 Jun 22.

Department of General Internal Medicine, Okayama City Hospital, Okayama, Japan.

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Cytisine induced urticaria : a case report during a smoking cessation treatment.

Acta Biomed 2022 Jun 22;93(S1):e2022073. Epub 2022 Jun 22.

Department of Medicine, Addiction Medicine Unit, Verona University Hospital, 37134 Verona, Italy .

Cytisine is considered to be the oldest medication for smoking cessation and has been used for this purpose in some Eastern/Central European and Central Asian countries for over 50 years. Several sources points towards cytisine's efficacy and effectiveness; it's well tolerated when taken at the recommended dose, and adverse events reported in trials are typically non-serious and self-limiting gastrointestinal and sleep disturbances. We report a suspect case of urticaria during treatment for smoking cessation with cytisine in a woman of 48 years treated for smoking at the Unit of Addiction Medicine, Department of Internal Medicine, Hospital Trust of Verona, Italy. Read More

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Urticaria and angioedema in children and adolescents: diagnostic challenge.

Allergol Immunopathol (Madr) 2022 17;50(S Pt 1):17-29. Epub 2022 May 17.

Division of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, McGill University Health Centre, Montreal, Canada.

Urticaria diagnosis may be challenging in children since it can be triggered or related to numerous conditions. In this paper, we reviewed the main aspects regarding the diagnosis of urticaria in the pediatric population. Acute urticaria is often due to viral infections. Read More

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Hereditary angioedema in children and adolescents.

Allergol Immunopathol (Madr) 2022 7;50(S Pt 1):1-6. Epub 2022 Apr 7.

Clinical Immunology, Centro Universitario FMABC, Santo André, Brazil;

Hereditary angioedema is a genetic disease with autosomal dominant inheritance and, in most cases, caused by C1 inhibitor deficiency. Patients present with recurrent edema affecting sub-cutaneous and mucus membranes with variable onset and severity. More than 50% of patients may become symptomatic before 10 years of age. Read More

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Omalizumab is not just an anti-immunoglobulin E.

J Dermatolog Treat 2022 Jun 20:1-4. Epub 2022 Jun 20.

Department of Dermatology, University of Gaziantep Faculty of Medicine, Gaziantep, Turkey.

Introduction And Purpose: The mechanism of omalizumab in urticaria is not literally known. Omalizumab may affect receptors on the mast cell surface in other ways, especially other than Fc epsilon RI.

Materials And Methods: Thirty patients who were treated with omalizumab with the diagnosis of chronic urticaria were included in the study. Read More

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Management of suspected and confirmed COVID-19 (SARS-CoV-2) vaccine hypersensitivity.

Allergy 2022 Jun 20. Epub 2022 Jun 20.

Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Technische Universität München.

Systemic allergic reactions to vaccines are very rare. In this study we assessed the management and outcome of suspected SARS-CoV-2 vaccine hypersensitivity. 334 individuals underwent an allergy work up regarding SARS-CoV-2 vaccination (group A: 115 individuals suspected to be at increased risk for vaccine related reactions before vaccination and group B: 219 patients with reactions after COVID vaccination). Read More

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The course of COVID-19 in patients with chronic spontaneous urticaria receiving omalizumab treatment.

Rev Fr Allergol (2009) 2022 Jun 13. Epub 2022 Jun 13.

University of Health Science, Konya City Hospital, Department of Allergy and Clinical Immunology, Konya, Turkey.

Background And Aim: Although there are case reports and guideline recommendations that states omalizumab can be used in chronic spontaneous urticaria (CSU) patients during SARS-CoV-2 pandemic, there are scarce studies showing the course of Coronavirus disease 2019 (COVID-19) in CSU patients receiving omalizumab.

Materials And Methods: A total of 370 patients with chronic urticaria were included in the study between June 2020 and December 31, 2020.

Results: Sixty patients (16. Read More

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Internalized stigma in chronic urticaria: A case-control study.

Australas J Dermatol 2022 Jun 18. Epub 2022 Jun 18.

Department of Dermatology and Venereology, Faculty of Medicine, Akdeniz University, Antalya, Turkey.

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Cutaneous manifestations following COVID-19 vaccination: A report of 25 cases.

Dermatol Ther 2022 Jun 18:e15651. Epub 2022 Jun 18.

Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Various adverse effects particularly cutaneous manifestations associated with different COVID-19 vaccines have been observed in practice.

Aim: To evaluate all patients who presented to our tertiary center with skin manifestations following COVID-19 vaccines injection from September to December 2021.

Method: All patients with skin manifestation within 30 days or less following COVID-19 vaccination were enrolled in our case-series. Read More

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IgG Autoantibodies Against IgE from Atopic Dermatitis Can Induce the Release of Cytokines and Proinflammatory Mediators from Basophils and Mast Cells.

Front Immunol 2022 31;13:880412. Epub 2022 May 31.

Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy.

IgE-mediated release of proinflammatory mediators and cytokines from basophils and mast cells is a central event in allergic disorders. Several groups of investigators have demonstrated the presence of autoantibodies against IgE and/or FcεRI in patients with chronic spontaneous urticaria. By contrast, the prevalence and functional activity of anti-IgE autoantibodies in atopic dermatitis (AD) are largely unknown. Read More

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The Role of Crosstalk of Immune Cells in Pathogenesis of Chronic Spontaneous Urticaria.

Front Immunol 2022 31;13:879754. Epub 2022 May 31.

Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China.

Chronic spontaneous urticaria (CSU) is defined as recurrent episodes of spontaneous wheal development and/or angioedema for more than six weeks and at least twice a week. The core link in the pathogenesis of CSU is the activation of mast cells, T cells, eosinophils, and other immune cells infiltrating around the small venules of the lesion. Increased vascular permeability, vasodilatation, and recruitment of inflammatory cells directly depend on mast cell mediators' release. Read More

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The symptom experience of hereditary angioedema (HAE) patients beyond HAE attacks: literature review and clinician interviews.

Orphanet J Rare Dis 2022 06 16;17(1):232. Epub 2022 Jun 16.

Evidera, 615 2nd Ave Ste 500, Seattle, WA, 98104, USA.

Background: Hereditary angioedema (HAE) is a genetic disorder characterized by re-occurring swelling episodes called "attacks," usually in the limbs, face, airways, and intestinal tract. New prophylactic therapies have reduced the frequency of these attacks. This study describes results from a literature review and clinician interviews assessing patient HAE symptom experiences and timing, and then evaluates whether existing patient-reported outcome (PRO) tools adequately reflect this experience. Read More

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Combined treatment with omalizumab and secukinumab in a patient with chronic spontaneous urticaria and psoriasis.

Dermatol Ther 2022 Jun 15:e15638. Epub 2022 Jun 15.

Pamukkale University, Department of Dermatology, Denizli, Turkey.

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Artificial intelligence processing electronic health records to identify commonalities and comorbidities cluster at Immuno Center Humanitas.

Clin Transl Allergy 2022 Jun 8;12(6):e12144. Epub 2022 Jun 8.

Department of Biomedical Sciences Humanitas University Milan Italy.

Background: Comorbidities are common in chronic inflammatory conditions, requiring multidisciplinary treatment approach. Understanding the link between a single disease and its comorbidities is important for appropriate treatment and management. We evaluate the ability of an NLP-based process for knowledge discovery to detect information about pathologies, patients' phenotype, doctors' prescriptions and commonalities in electronic medical records, by extracting information from free narrative text written by clinicians during medical visits, resulting in the extraction of valuable information and enriching real world evidence data from a multidisciplinary setting. Read More

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Chronic Urticaria in a Child With Nephrotic Syndrome: A Double Whammy!

Indian Pediatr 2022 Jun;59(6):505-506

Department of Dermatology, Venereology and Leprology, Sardar Patel Medical College, Bikaner, Rajasthan.

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Reporting adverse events of COVID-19 vaccines: The case of Bulgaria.

PLoS One 2022 10;17(6):e0269727. Epub 2022 Jun 10.

Department of Epidemiology and Disaster Medicine, Faculty of Public Health, Medical University of Plovdiv, Plovdiv, Bulgaria.

As a member state of the European Union, where vaccines against COVID-19 are available and affordable, Bulgaria reports the lowest immunization coverage and the most pronounced vaccine distrust. The present study aimed to assess the self-reported adverse reactions following COVID-19 vaccination as a possible tool to increase the trust in vaccines. A cross-sectional survey-based study, covering 761 vaccinated respondents, was conducted in Plovdiv (469 with an mRNA vaccine and 292 with an adenoviral vector vaccine). Read More

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The Burden on Cohabitants of Patients with Chronic Spontaneous Urticaria: A Cross-Sectional Study.

J Clin Med 2022 Jun 6;11(11). Epub 2022 Jun 6.

Dermatology Unit, Hospital Universitario Virgen de las Nieves, IBS Granada, 18002 Granada, Spain.

Chronic Spontaneous Urticaria (CSU) has been associated with patients' poor quality of life. Despite being a chronic disease that could alter the quality of life of the people who live with patients, the potential burden on their cohabitants has not been studied to date. The aim of this study is to analyze the relationship between the patient's quality of life, disease control, disease duration and family quality of life and the cohabitant's mood disturbances, sexual dysfunction, type D personality and sleep quality. Read More

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Rome IV Criteria-Defined Irritable Bowel Syndrome in Atopic Patients and the Effect of Anxiety and Depression: A Case-Control Study.

Turk J Gastroenterol 2022 May;33(5):397-405

Department of Internal Medicine, Gastroenterology Division, Akdeniz University Faculty of Medicine, Antalya, Turkey.

Background: Numerous studies report an increased prevalence of irritable bowel syndrome in patients with atopic diseases such as allergic rhinitis, allergic asthma, and chronic urticaria. Both disease groups have a higher incidence of psychological disorders. In this study, we aimed to examine the relationship of irritable bowel syndrome with the presence and severity of allergic diseases and accom- panying anxiety and depression. Read More

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Corrigendum: Circadian Pharmacological Effects of Paeoniflorin on Mice With Urticaria-like Lesions.

Front Pharmacol 2022 19;13:918401. Epub 2022 May 19.

Chengdu University of Traditional Chinese Medicine, Chengdu, China.

[This corrects the article DOI: 10.3389/fphar.2021. Read More

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Autoimmune chronic spontaneous urticaria.

J Allergy Clin Immunol 2022 Jun;149(6):1819-1831

Institute of Allergology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, and Humboldt-Universität zu Berlin, Berlin, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany. Electronic address:

Chronic spontaneous urticaria (CSU) is a debilitating mast cell-driven disease characterized by recurrent wheals and/or angioedema. Substantial progress has been made in dissecting the 2 main autoimmune mechanisms that drive the pathogenesis of CSU. Type I autoimmune (autoallergic) CSU is associated with IgE antibodies against autoantigens, for example, thyroid peroxidase and IL-24. Read More

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Case of borderline leprosy presenting with urticaria-like eruptions and limbs swelling: A lesson to be learned for dermatologists.

J Dermatol 2022 Jun 6. Epub 2022 Jun 6.

Department of Dermatology, The Second Xiangya Hospital, Central South University, Changsha, China.

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The Potential Role of Basophils in Urticaria.

Front Immunol 2022 17;13:883692. Epub 2022 May 17.

Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Urticaria is a symptom of acute skin allergies that is not clearly understood, but mast cell histamine is hypothesized to cause swelling and itching. Omalizumab, an anti-human IgE antibody that traps IgE and prevents its binding to high-affinity IgE receptors, is effective in treating urticaria. We recently experienced a case of urticaria refractory to antihistamine therapy in which the peripheral-blood basophil count responded to omalizumab therapy and its withdrawal. Read More

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Diversities of allergic pathologies and their modifiers: Report from the second DGAKI-JSA meeting.

Allergol Int 2022 Jun 2. Epub 2022 Jun 2.

Division of Allergy and Immunology, Department of Dermatology, Venereology and Allergology, Charité Universitätsmedizin Berlin, Berlin, Germany.

In October 2021, researchers from the German Society of Allergy and Clinical Immunology (DGAKI) and from the Japanese Society of Allergology (JSA) focused their attention on the pathological conditions and modifiers of various allergic diseases. Topics included 1) the pathophysiology of IgE/mast cell-mediated allergic diseases; 2) the diagnosis and prevention of IgE/mast cell-mediated diseases; 3) the pathophysiology, diagnosis, and treatment of eosinophilic airway diseases; and 4) host-pathogen interaction and allergic diseases. This report summarizes the panel discussions, which highlighted the importance of recognizing the diversity of genetics, immunological mechanisms, and modifying factors underlying allergic diseases. Read More

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Comprehensive Review on Banana Fruit Allergy: Pathogenesis, Diagnosis, Management, and Potential Modification of Allergens through Food Processing.

Plant Foods Hum Nutr 2022 Jun 3;77(2):159-171. Epub 2022 Jun 3.

Department of Food Safety and Quality Testing, National Institute of Food Technology, Entrepreneurship and Management (NIFTEM), Thanjavur, Tamil Nadu, 613005, India.

The pulp of the banana fruit is rich in bioactive compounds like dietary fibers, low glycemic carbohydrates, natural sugars, vitamins, minerals and antioxidants. These beneficial compounds are responsible for the proper functioning of immune system and enhance prevention against various deadly diseases like cancer, diabetes and heart diseases. Despite having, positive effects, the fruit are recognized as an important source for causing allergy to 0. Read More

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