23,102 results match your criteria Urticaria


Evaluation of Dermatology Consultations in a Tertiary Care Centre Emergency Service.

Sisli Etfal Hastan Tip Bul 2020 18;54(2):197-200. Epub 2020 May 18.

Department of Dermatology, Sisli Etfal Training and Research Hospital, Istanbul, Turkey.

Objectives: The primary objective of our study was to investigate the profile of patients visiting our hospital's emergency department and underwent dermatology consultation.

Methods: In this study, we reviewed electronic medical records of 444 consultations from the emergency department over a period from 01.05. Read More

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http://dx.doi.org/10.14744/SEMB.2018.72473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326684PMC

Assessment of thiol/disulphide homeostasis and ischemia modified albumin and their relationship with disease severity in children with chronic urticaria.

Cutan Ocul Toxicol 2020 Jul 2:1-19. Epub 2020 Jul 2.

Department of Biochemistry, Yildirim Beyazit University Faculty of Medicine, Ankara, Turkey.

The pathogenesis chronic urticaria (CU) hasn't been fully understood. In recent years, it has been shown that thiol-disulphide homeostasis, as an antioxidant system, plays important roles in both healthy individuals and various diseases. In different ischemia-reperfusion states high oxidative stress causes ischemia modified albumin (IMA) generation. Read More

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http://dx.doi.org/10.1080/15569527.2020.1790589DOI Listing

Pearls and pitfalls: Cold-induced urticaria.

Allergy Asthma Proc 2020 Jul;41(4):301-304

Division of Allergy and Immunology, Naval Medical Center Portsmouth, Portsmouth, Virginia.

Cold-induced urticaria can take place either due to direct cold exposure, cryoglobulinemia, or genetic component (such as cryopyrin-associated periodic syndrome), which leads to the rapid onset of urticaria and/or angioedema. It is more common in younger patients and more likely to affect females compared with males. To increase awareness of such systemic reactions of anaphylaxis and provide a focused review of the differential diagnosis, underlying mechanisms, broad workup, and management of this disease process for allergy/immunology fellows, residents, general physicians, and general practitioners. Read More

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http://dx.doi.org/10.2500/aap.2020.41.200033DOI Listing

Necrobiosis Lipoidica in a Patient with β-Thalassemia Major: A Case Report and Review of the Literature.

Hemoglobin 2020 Jul 1:1-3. Epub 2020 Jul 1.

Adult Thalassemia Unit, Second Department of Internal Medicine, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Necrobiosis lipoidica (NL) is a rare granulomatous disease that predominantly affects middle-aged women and is often associated with diabetes mellitus (DM), rheumatoid arthritis (RA) and other metabolic disorders. Thalassemias are the most common hereditary hemoglobin (Hb) disorders worldwide. A few studies investigated dermatologic problems that coexist with β-thalassemia major (β-TM). Read More

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http://dx.doi.org/10.1080/03630269.2020.1783287DOI Listing

Follicular traction urticaria induced by electric epilation.

Cutis 2020 May;105(5):E23-E24

Pontificia Universidad Católica de Chile, Santiago, Chile.

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Novel Therapeutic Approaches And Targets For Treatment Of Chronic Urticaria: New Insights And Promising Targets For A Challenging Disease.

Curr Pharm Biotechnol 2020 Jun 30. Epub 2020 Jun 30.

Dermatological Clinic, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona. Italy.

Background: Chronic spontaneous urticaria (CSU) is a disease characterized by the onset of wheals and/or angioedema over 6 weeks. The pathophysiology for CSU is very complex, involving mast cells and basophils with a multitude of inflammatory mediators. For many years the treatment of CSU has been based on the use of antihistamines, steroids and immunosuppressive agents with inconstant and frustrating results. Read More

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http://dx.doi.org/10.2174/1389201021666200630140137DOI Listing

Cyclosporin in Dermatology: A Practical Compendium.

Dermatol Ther 2020 Jun 30:e13934. Epub 2020 Jun 30.

Department of Medicine, The Aga Khan University Hospital, Karachi-Pakistan.

Cyclosporine A belongs to calcineurin inhibitor family, which has the ability to selectively suppress T-cells. Owing to its immune-modulatory effects, it had been in use for graft versus host diseases and organ transplant rejection for many years, but in dermatology, it was first approved for use in 1997 in the treatment of psoriasis. Other off label indications for skin diseases includes atopic dermatitis, chronic spontaneous urticaria, lichen planus, pyoderma gangrenosum, alopecia areata, granuloma annulare and several others. Read More

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http://dx.doi.org/10.1111/dth.13934DOI Listing

COVID-19 and dermatology.

Authors:
Ülker GÜl

Turk J Med Sci 2020 Jun 30. Epub 2020 Jun 30.

Sars-CoV-2 virus infection (COVID-19) was observed in China in the last months of 2019. In the following period, this infection spread all over the world. In March 2020, the World Health Organization announced the existence of a pandemic. Read More

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http://dx.doi.org/10.3906/sag-2005-182DOI Listing

The first case of tegoprazan-induced urticaria.

J Clin Pharm Ther 2020 Jun 29. Epub 2020 Jun 29.

Division of Allergy, Asthma, and Clinical Immunology, Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.

What Is Known And Objective: Tegoprazan induces adverse drug reactions during clinical trials; however, tegoprazan-induced urticaria has not been reported. Here, we describe the first case of this.

Case Description: A 55-year-old woman presented with acute urticaria with pruritus after taking the gastro-oesophageal reflux disease medication, tegoprazan. Read More

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http://dx.doi.org/10.1111/jcpt.13150DOI Listing

Methotrexate combined with omalizumab for difficult to treat urticaria: a further step-up treatment?

Clin Exp Dermatol 2020 Jun 29. Epub 2020 Jun 29.

Department of Dermatology, Ninewells Hospital and Medical School, Dundee, UK.

Classically, chronic urticaria has been treated following a stepwise approach where Omalizumab and other immunosuppressants occupy the last step. Omalizumab and Methotrexate have both been used separately for the treatment of urticaria . We believe combination treatment with both agents is a valuable alternative for refractory chronic urticaria and other related diseases such as urticarial vasculitis. Read More

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http://dx.doi.org/10.1111/ced.14359DOI Listing

Experience with Omalizumab for the Treatment of Chronic Spontaneous Urticaria in a Tertiary Center: Real life experience.

Cutan Ocul Toxicol 2020 Jun 28:1-16. Epub 2020 Jun 28.

Department of Dermatology and Venereology, Ege University Faculty of Medicine, Izmir.

Purpose: Chronic spontaneous urticaria (CSU) is defined as urticaria and/or angioedema that appears spontaneously due to known or unknown causes and lasts for at least 6 weeks. Omalizumab, an anti-IgE antibody that binds circulating free IgE, has recently emerged as a promising treatment for CSU, a condition which impairs patients' quality of life. We aimed to contribute real life data by reporting our experience with omalizumab in the treatment of intractable CSU. Read More

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http://dx.doi.org/10.1080/15569527.2020.1787432DOI Listing

Cholinergic Urticaria: Clinical Presentation and Natural History in a Tropical Country.

Biomed Res Int 2020 24;2020:7301652. Epub 2020 May 24.

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Cholinergic urticaria (CholU) is a subset of chronic inducible urticaria characterized by the recurrent pinpoint-sized wheals that are induced by exercising or increasing core body temperature. Currently, the data of CholU in tropical climate is still limited.

Objective: To investigate the clinical features and natural course of CholU in a tropical country. Read More

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http://dx.doi.org/10.1155/2020/7301652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273400PMC

FACTORS CONTRIBUTING TO CHRONIC URTICARIA/ANGIOEDEMA AND NUMMULAR ECZEMA RESOLUTION - WHICH FINDINGS ARE CRUCIAL?

Acta Clin Croat 2019 Dec;58(4):595-603

1Department of Dermatovenereology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 2School of Dental Medicine, University of Zagreb, Zagreb, Croatia.

When working with dermatology patients, the question sometimes arises which diagnostic tests and tools should be used for workup, particularly in cases of chronic urticaria (CU) and discoid nummular eczema, where the treatment of associated systemic diseases and infections may be crucial for patient outcome. The aim was to investigate retrospectively the influence of associated diseases on skin disease outcomes based on medical records of CU and nummular eczema patients in comparison to controls. We included patients admitted to our Dermatology Department over a 6-year period and analyzed their laboratory findings, related factors and outcomes recorded after two years of workup and treatment. Read More

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http://dx.doi.org/10.20471/acc.2019.58.04.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314308PMC
December 2019

Dermatoses of the world: Burden of skin disease and associated socioeconomic status in the world.

J Am Acad Dermatol 2020 Jun 25. Epub 2020 Jun 25.

Apex Dermatology and Skin Surgery Center, Mayfield Heights, OH; Lake Erie College of Osteopathic Medicine, Erie, PA.

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http://dx.doi.org/10.1016/j.jaad.2020.05.157DOI Listing

Occupational Airborne Contact Urticaria, Anaphylaxis and Asthma in Farmers and Agronomists Due to Bruchus Pisorum.

Contact Dermatitis 2020 Jun 26. Epub 2020 Jun 26.

Laboratorios DIATER. Madrid., Spain.

Background: Occupational contact urticaria due to inhalation of legume pest allergens has rarely been described.

Objective: To determine the cause of an outbreak of airborne contact urticaria, asthma and anaphylaxis in farmers and agronomists studying the disinsectization of dried peas. Peas were treated with aluminum phosphide (EPA). Read More

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http://dx.doi.org/10.1111/cod.13644DOI Listing

Characteristics and risk factors of children with sleep-disordered breathing in Wuxi, China.

BMC Pediatr 2020 Jun 26;20(1):310. Epub 2020 Jun 26.

Department of Pediatric Respiratory, Wuxi Children's Hospital, Wuxi Clinical Medical College Affiliated to Nanjing Medical University, No.299-1 at Qingyang Road, Liangxi District, 214023, Wuxi, Jiangsu Province, People's Republic of China.

Background: Sleep-disordered breathing (SDB) is a common syndrome in children, related to their immune responses, cardiovascular function, and neurocognitive function. This study aimed to determine the prevalence of SDB among children in Wuxi, China, and to evaluate the protective and risk factors of SDB in children.

Methods: A cross-sectional study was conducted on children attending different schools across Wuxi, China, aged 3-14 years old. Read More

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http://dx.doi.org/10.1186/s12887-020-02207-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318769PMC

Urticaria and the gut.

Curr Opin Allergy Clin Immunol 2020 Aug;20(4):381-385

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Dermatology and Allergy, Allergy Center Charité, Berlin, Germany.

Purpose Of Review: To review recent evidence on the association of urticaria and the gut diseases, focusing on the roles of chronic inflammation with or without Helicobacter pylori (H. Pylori) infection.

Recent Findings: The connection between the gut and urticaria has been discussed for a long time. Read More

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http://dx.doi.org/10.1097/ACI.0000000000000653DOI Listing

The role of IL-17, IL-23 and IL-31, IL-33 in allergic skin diseases.

Curr Opin Allergy Clin Immunol 2020 Aug;20(4):367-373

Department of Dermatology, Venereology and Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Purpose Of Review: Allergic skin diseases such as urticaria, atopic dermatitis and allergic contact dermatitis are among the most common skin diseases with severe socioeconomic consequences. The pathogenesis of allergic skin diseases is complex. This review provides an overview of cytocines IL-17, IL-23, IL-31 and IL-33. Read More

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http://dx.doi.org/10.1097/ACI.0000000000000658DOI Listing

Severe chronic spontaneous urticaria in children - treatment options according to the guidelines and beyond - a 10 years review.

J Dermatolog Treat 2020 Jun 26:1-4. Epub 2020 Jun 26.

Department of Dermatology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

This is a retrospective study of 18 children with chronic spontaneous urticaria (CSU), where standard therapies, including up-dosing of antihistamines and omalizumab, were unable to cure the disease and where alternative strategies with experimental and off-label medication had to be used. Being aware that our questionnaire is validated only for elder children or adults, we utilized the UAS7 to monitor disease control with the help of the parents. The UAS7 score decreased from a mean of 25 to an average of 13 after 8 weeks of therapy in 13 patients. Read More

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http://dx.doi.org/10.1080/09546634.2020.1782326DOI Listing

Relapsing symmetric livedo reticularis in a patient with COVID-19 infection.

J Eur Acad Dermatol Venereol 2020 Jun 25. Epub 2020 Jun 25.

Department of Internal Medicine, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel (VUB), Laarbeeklaan 101, 1090, Jette, Brussels, Belgium.

During the Coronavirus 2019 (COVID-19) pandemic, several associated skin conditions were reported in infected patients, including; urticaria [1], exanthema [1], erythema multiforme [2], chickenpox-like vesicles [1], pityriasis rosea [3], herpes simplex reactivation [4], erythema nodosum like Sweet's syndrome [5], Symmetrical Drug-Related Intertriginous and Flexural Exanthema [6], petechial rash [7], vasculitic purpura [7], acro-ischemia/necrosis [8], Kawasaki disease [2] and chilblain lesions [9]. Read More

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http://dx.doi.org/10.1111/jdv.16773DOI Listing

Occupational allergic contact dermatitis and contact urticaria caused by indoor plants in plant keepers.

Contact Dermatitis 2020 Jun 25. Epub 2020 Jun 25.

Occupational Health Unit, Finnish Institute of Occupational Health, Helsinki, Finland.

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http://dx.doi.org/10.1111/cod.13647DOI Listing

Down-regulation of Gremlin1 inhibits inflammatory response and vascular permeability in chronic idiopathic urticaria through suppression of TGF-β signaling pathway.

Gene 2020 Jun 21:144916. Epub 2020 Jun 21.

Department of Dermatology, The Second Hospital of Jilin University, Changchun 130041, P.R. China. Electronic address:

Chronic idiopathic urticaria (CIU) is an unfavorable skin condition which could be maintained for six weeks or longer time. Gremlin1 (GREM1) was recently applied in treatments of many diseases. However, the possible regulatory mechanism of GREM1 in CIU remained unclear. Read More

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http://dx.doi.org/10.1016/j.gene.2020.144916DOI Listing

The Mast Cell-SCF-CB1 Interaction Is a Key Player in Seborrheic Keratosis.

J Histochem Cytochem 2020 Jun 24:22155420938031. Epub 2020 Jun 24.

Department of Dermatology, Graduate School of Medicine, Osaka City University, Osaka, Japan (MY-T, KS, RS, DT).

Mast cell (MC) is an important player in the development of skin diseases, including atopic dermatitis, psoriasis, and urticaria. It is reported that MC infiltration and activation are observed around various types of tumors and speculated that MCs play key roles in their pathogenesis. As MCs in human seborrheic keratosis (SK) have not been well investigated, here we focused on the MCs in SK. Read More

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http://dx.doi.org/10.1369/0022155420938031DOI Listing

Inpatient Dermatology Consultations during Covid 19 Pandemic in a Tertiary Referral Center.

Dermatol Ther 2020 Jun 23. Epub 2020 Jun 23.

Istanbul University Cerrahpasa Medical Faculty Department of Dermatology.

Since the COVID-19 infection first appeared in December 2019, patient profile of outpatient and inpatient clinics have changed. Various cutaneous findings associated with COVID-19 have been reported in the literature. The main objective of this study was to describe and analyze the profile of the consultations requested from dermatology department during the COVID pandemic. Read More

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http://dx.doi.org/10.1111/dth.13883DOI Listing

Cold urticaria comorbid with heat urticaria: A case report.

J Dermatol 2020 Jun 23. Epub 2020 Jun 23.

Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan.

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http://dx.doi.org/10.1111/1346-8138.15463DOI Listing

Histopathological Study of a Broad Spectrum of Skin Dermatoses in Patients Affected or Highly Suspected of Infection by COVID-19 in the Northern Part of Italy: Analysis of the Many Faces of the Viral-Induced Skin Diseases in Previous and New Reported Cases.

Am J Dermatopathol 2020 Jun 10. Epub 2020 Jun 10.

Division of Pathology, Università degli Studi di Milano, Foundation IRCCS, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.

Skin manifestations of COVID-19 infections are diverse and are new to the dermatology community. We had the opportunity to examine the clinical and histopathological features of several patients who were divided into 3 groups. The first group included 8 COVID-19-positive patients who were hospitalized and quarantined at home. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001707DOI Listing

Cutaneous side effects of hydroxychloroquine in health care workers in a COVID referral hospital - implications for clinical practice.

J Dermatolog Treat 2020 Jun 22:1-3. Epub 2020 Jun 22.

Department of Dermatology and STDs, Dr RML Hospital and PGIMER, New Delhi, India.

The utility of hydroxychloroquine for the prophylaxis and treatment of alarmingly rising COVID-19 infection has been widely explored in several studies. However, its cutaneous adverse effects among health care workers and COVID patients taking prophylactic doses has not been reported. We report cases of palmoplantar among health care workers who were on prophylactic doses of hydroxychloroquine and their management with cetirizine and methylprednisolone. Read More

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http://dx.doi.org/10.1080/09546634.2020.1781041DOI Listing

A New Digital Method for Counting Mast Cells in Cutaneous Specific Lesions of Mastocytosis: A Series of Adult Cases of Mastocytosis With Clinical-Pathological Correlations.

Am J Dermatopathol 2020 Jun 17. Epub 2020 Jun 17.

Service d'Anatomie et Cytologie Pathologiques, Hôpital Necker-Enfants Malades, APHP, Paris, France.

Cutaneous mastocytosis is characterized by the abnormal accumulation of mast cells in the skin. However, mast cell counting is not always easy and reproducible with classical methods. This work aims to demonstrate the reliability, usability, and virtues of a new software used on digital tablets for counting mast cells in cutaneous specific lesions of mastocytosis, to assess differences in mast cell counts between clinical subtypes of mastocytosis in the skin, and to consider the feasibility of applying a diagnostic mast cell count cutoff to urticaria pigmentosa, which is the most frequent form of cutaneous mastocytosis. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001705DOI Listing

Allergy clinics in times of the SARS-CoV-2 pandemic: an integrated model.

Clin Transl Allergy 2020 18;10:23. Epub 2020 Jun 18.

Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center IRCCS, Via Alessandro Manzoni 56, Rozzano, MI Italy.

Background: Almost the entire World is experiencing the Coronavirus-Disease-2019 (COVID-19) pandemic, responsible, at the end of May 2020, of more than five million people infected worldwide and about 350,000 deaths. In this context, a deep reorganization of allergy clinics, in order to ensure proper diagnosis and care despite of social distancing measures expose, is needed.

Main Text: The reorganization of allergy clinics should include programmed checks for severe and poorly controlled patients, application of digital medicine service for mild-to-moderate disease in well-controlled ones, postponement of non urgent diagnostic work-ups and domiciliation of therapies, whenever possible. Read More

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http://dx.doi.org/10.1186/s13601-020-00333-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299638PMC

A rare case of anaphylaxis to Indian jujube ().

Allergy Asthma Clin Immunol 2020 17;16:48. Epub 2020 Jun 17.

Division of Allergy & Immunology, Department of Medicine, Queen's University, Hotel Dieu Hospital, 166 Brock Street, Kingston, ON K7L 5G2 Canada.

Background: Indian jujube () is a sweet fruit from a tree native to tropical and subtropical regions of Asia and India. A few case reports have implicated Indian jujube to cause latex-fruit syndrome. We present the first case of an anaphylactic reaction to this fruit in a patient with no latex allergy. Read More

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http://dx.doi.org/10.1186/s13223-020-00444-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302346PMC

Normocomplementemic Urticarial Vasculitis: An Unusual Presentation.

Indian J Dermatol 2020 May-Jun;65(3):208-210

Department of Internal Medicine, Baby Memorial Hospital, Kozhikode, Kerala, India.

Urticarial vasculitis (UV) is a form of cutaneous vasculitis which lasts for >24 h. Clinically, the patients present with erythema and wheals. The level of complement decides the type of UV. Read More

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http://dx.doi.org/10.4103/ijd.IJD_227_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292463PMC

Comparative safety of high-dose versus standard-dose influenza vaccination in patients with end-stage renal disease.

Vaccine 2020 Jul 19;38(33):5178-5186. Epub 2020 Jun 19.

Division of Infectious Diseases, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA; Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA. Electronic address:

Background: High-dose influenza vaccine (HDV) is an alternative vaccination strategy in patients with end-stage renal disease (ESRD), though the safety of HDV has not been evaluated in this population. The objective of this study was to estimate the relative occurrence of adverse vaccine reactions in patients with ESRD following vaccination with HDV compared with standard-dose influenza vaccine (SDV).

Methods: Using data from the United States Renal Data System, we identified patients with ESRD aged ≥ 65 years at influenza vaccination during yearly influenza seasons from 2010 through 2016. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332402PMC

Direct and indirect action modes of acetylcholine in cholinergic urticaria.

Authors:
Yoshiki Tokura

Allergol Int 2020 Jun 18. Epub 2020 Jun 18.

Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan. Electronic address:

Cholinergic urticaria (CholU) manifests small, itchy and/or painful wheals occurring upon perspiration and mechanically involving acetylcholine (Ach). Although a considerable number of studies have been conducted, the pathomechanisms underlying perspiration-associated release of histamine remain to be elucidated. We have proposed that CholU can be categorized into two major subtypes: Ach-indirectly induced, sweat allergic type and Ach-directly induced, depressed sweating type. Read More

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http://dx.doi.org/10.1016/j.alit.2020.05.006DOI Listing

Metamizole-induced reactions as a paradigm of drug hypersensitivity: Non-allergic reactions, anaphylaxis, and delayed-type allergy.

Clin Exp Allergy 2020 Jun 21. Epub 2020 Jun 21.

Department of Dermatology and Allergy, University Hospital Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1111/cea.13689DOI Listing

Is vitamin D concentration an indicator of the severity of atopic dermatitis and chronic spontaneous urticaria in adults?

Pol Merkur Lekarski 2020 Jun;48(285):166-169

Department of Dermatology, Jagiellonian University Medical College, Krakow, Poland.

Atopic dermatitis (AD) and chronic spontaneous urticaria (CSU) are common chronic and recurrent dermatoses. The role of vitamin D in the immunological processes, including the development of inflammation, has been the subject of numerous studies. The feasible measurement of vitamin D serum concentration and possibly supplementation necessitates the assessment of its impact on the clinical severity of mentioned diseases. Read More

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Live-interactive teledermatology program in Taiwan: One-year experience serving a district hospital in rural Taitung County.

J Formos Med Assoc 2020 Jun 17. Epub 2020 Jun 17.

Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address:

Background/purpose: Population aging and unequal accessibility of health care are increasingly important in developed countries. One strategy to overcome these issues is utilizing telemedicine, which is recently made possible technologically by the advancement of internet speed, high speed zooming cameras, and the information storages. In Taiwan, the telemedicine is granted legally by the amendment for Taiwan's Physician Act in 2018. Read More

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http://dx.doi.org/10.1016/j.jfma.2020.06.007DOI Listing

Review of monoclonal antibody therapies in asthma and allergic diseases - a new paradigm for precision medicine.

Asian Pac J Allergy Immunol 2020 Jun;38(2):78-90

Faculty of Life Sciences & Medicine, School of Immunology & Microbial Sciences, Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, London, UK.

Background: Elucidation of the critical immune pathways involved in allergic inflammation has identified, apart from IgE, therapeutic targets in the cytokine network suitable for intervention by biological therapies.

Objective: The drugs that target the cytokine networks pertinent to asthma and allergic diseases are reviewed and some illustrative case histories presented. The overview proposes a framework to use when deciding which monoclonal antibody (mAb) to select for treatment of severe asthma based on total IgE concentration, peripheral blood eosinophil count, induced sputum analysis and measurement of fractional exhaled nitric oxide (FENO). Read More

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http://dx.doi.org/10.12932/AP-020220-0752DOI Listing

Oral mucosa lesions in COVID-19.

Oral Dis 2020 Jun 19. Epub 2020 Jun 19.

Department of Periodontology, Faculty of Dentistry, Iuliu Haţieganu" University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca, Romania.

SARS-CoV-2 marks a new era in the medical field. The literature has outlined several signs and symptoms of COVID-19 (Lake, 2020), but there are some manifestations not yet confirmed or not entirely described. There have been reported several dermatological conditions associated with COVID-19: rash, urticaria and chickenpox-like vesicles (Recalcati, 2020) and studies on cutaneous manifestations of COVID-19 have been announced (Fernandez-Nieto et al. Read More

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http://dx.doi.org/10.1111/odi.13499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323044PMC

Prevalence of chronic urticaria refractory to antihistamines in andalucia, spain.

Dermatol Ther 2020 Jun 18:e13866. Epub 2020 Jun 18.

Department of Dermatology, Hospital Universitario San Cecilio, Granada, Spain.

Introduction: Chronic urticaria (CU) has a devastating effect on the quality of life of patients who suffer from it. The objective of this study is to determine the prevalence of severe CSU in adults in 8 health areas in Andalucía.

Material And Methods: A retrospective observational study from January to December 2019 was conducted with the participation of 7 reference hospitals that were analysed, including including a total reference population of 3. Read More

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http://dx.doi.org/10.1111/dth.13866DOI Listing

Gleich syndrome: a systematic review.

Int J Dermatol 2020 Jun 18. Epub 2020 Jun 18.

Dermatology Department, Faculty of Medicine, Balamand University, Saint Georges Hospital UMC, Beirut, Lebanon.

Characterized chiefly by hypereosinophilia and angioedema, Gleich syndrome is a rare disorder with unclear clinical and therapeutic findings. Other symptoms include increased IgM levels, weight gain, fever, and urticaria. Herein we review Gleich syndrome and assess clinical features, epidemiology, and treatment options. Read More

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http://dx.doi.org/10.1111/ijd.14963DOI Listing

Chiral Discrimination of P-glycoprotein in Parturient Women: Effect of Fluoxetine on Maternal-Fetal Fexofenadine Pharmacokinetics.

Pharm Res 2020 Jun 17;37(7):131. Epub 2020 Jun 17.

Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brazil.

Background And Objective: Fluoxetine, antidepressant widely-used during pregnancy, is a selective inhibitor for P-glycoprotein (P-gp). Fexofenadine, an in vivo P-gp probe, is an antihistamine drug for seasonal allergic rhinitis and chronic urticaria treatment during pregnancy and it is available as a racemic mixture. This study evaluated the chiral discrimination of P-gp investigating the effect of fluoxetine on maternal-fetal pharmacokinetics of fexofenadine. Read More

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http://dx.doi.org/10.1007/s11095-020-02854-4DOI Listing

Hereditary Alpha-Tryptasemia: UK Prevalence and variability in disease expression.

J Allergy Clin Immunol Pract 2020 Jun 15. Epub 2020 Jun 15.

Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity & Respiratory Medicine, School of Biological Sciences, University of Manchester, UK. Electronic address:

Background: Hereditary Alpha-Tryptasemia (HAT) is a genetic trait caused by an increased alpha-tryptase TPSAB1 gene copy number. Basal serum mast cell tryptase is typically ≥8.0ng/ml. Read More

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http://dx.doi.org/10.1016/j.jaip.2020.05.057DOI Listing

Hypersensitivity reactions to biologics (part I): allergy as an important differential diagnosis in complex immune-derived adverse events.

Allergo J 2020 24;29(4):32-61. Epub 2020 Jun 24.

Klinische und Molekulare Allergologie - Forschungszentrum Borstel, Parkallee 35, 23845 Borstel, Germany.

Biotechnological substances (BSs) are strongly relied upon to prevent rejection of transplanted organs, and to treat oncological, allergological, and other inflammatory diseases. Allergic reactions to partly foreign biologics can occur due to their potential immunogenicity. The severity of an immune response to a biological drug may range from no clinical significance to a severe, life-threatening anaphylactic reaction. Read More

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http://dx.doi.org/10.1007/s15007-020-2550-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289641PMC

Efficacy of Omalizumab in Chronic Spontaneous Urticaria Associated with Chronic Inducible Urticaria.

Ann Allergy Asthma Immunol 2020 Jun 13. Epub 2020 Jun 13.

Serviço de Imunologia, Hospital Universitário Clementino Fraga Filho (HUCFF-UFRJ).

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http://dx.doi.org/10.1016/j.anai.2020.06.011DOI Listing

Heater-Associated Erythema Ab Igne: Case Report and Review of Thermal-Related Skin Conditions.

Cureus 2020 May 11;12(5):e8057. Epub 2020 May 11.

Dermatology, San Diego Family Dermatology, National City, USA.

Erythema ab igne is a thermal-associated skin condition that can occur secondary to persistent direct or indirect contact with heat. Historically, erythema ab igne has been linked to fireplace and stove exposures; more recently, it has been associated with heaters, hot water bottles, and laptops. A 48-year-old woman presented for the evaluation of hyperpigmented, reticulated macular lesions on her distal legs. Read More

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http://dx.doi.org/10.7759/cureus.8057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7286585PMC

Novel Gene Deletion in NLRC4 Expanding the Familial Cold Inflammatory Syndrome Phenotype.

Allergy Rhinol (Providence) 2020 Jan-Dec;11:2152656720928062. Epub 2020 Jun 2.

Allergy and Immunology Associates Inc., Mayfield Heights, Ohio.

Familial cold inflammatory syndrome (FCAS) is a rare, inherited inflammatory disease characterized by episodes of fever, rash, and arthralgias after exposure to cold stimuli. Previous literature has established FCAS linked to autosomal dominant mutations in the NLRP3 (CIAS1) and NLRP12 genes. Moreover, there has been recent evidence of NLRC4-inflammasomopathies. Read More

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http://dx.doi.org/10.1177/2152656720928062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268108PMC

Recurrent Type III Kounis Syndrome: Will Anti-Immunoglobulin E Drug Be Another Option?

Can J Cardiol 2020 Jun 10;36(6):966.e5-966.e6. Epub 2019 Dec 10.

Division of Cardiology, Tianjin 1st Central Hospital, Tianjin, China. Electronic address:

Kounis syndrome was recognized as the concurrence of acute cardiovascular events with hypersensitivity reactions. We report a case of Kounis syndrome type III (coronary thrombosis) variant in a 48-year-old man who had experienced recurrent acute myocardial infarctions after scallion-induced hypersensitivity reactions. After appropriate antithrombotic, antihistamine, and reperfusion strategies, the patient was found to have elevated levels of immunoglobulin E and chronic urticaria. Read More

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http://dx.doi.org/10.1016/j.cjca.2019.12.007DOI Listing