24,055 results match your criteria Urticaria


Pharmacokinetics and Safety of a Bilastine Once-Daily, Preservative-Free, Ophthalmic Formulation.

Adv Ther 2021 Jun 12. Epub 2021 Jun 12.

Department of Research, Development, and Innovation, FAES FARMA, Av. Autonomía 10, 48940, Leioa, Spain.

Introduction: Bilastine is a second-generation H antihistamine indicated for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria. On the basis of the demonstrated efficacy and safety of the oral formulation, a new ophthalmic formulation of bilastine was recently developed. Previous preclinical studies had indicated that bilastine is mainly absorbed by the conjunctiva and shows low plasma concentration. Read More

View Article and Full-Text PDF

Basophil Activation Test for Allergy Diagnosis.

J Vis Exp 2021 May 31(171). Epub 2021 May 31.

Allergy Unit, Hospital Regional Universitario de Málaga; Allergy Research Group, Instituto de Investigación Biomédica de Málaga-IBIMA; Departamento de Medicina, Universidad de Málaga; Nanostructures for Diagnosing and Treatment of Allergic Diseases Laboratory, Andalusian Center for Nanomedicine and Biotechnology-BIONAND.

The basophil activation test (BAT) is a complementary in vitro diagnostic test that can be used in addition to clinical history, skin test (ST), and specific IgE (sIgE) determination in the evaluation of IgE-mediated allergic reactions to food, insect venom, drugs, as well as some forms of chronic urticaria. However, the role of this technique in the diagnostic algorithms is highly variable and not well determined. BAT is based on the determination of basophil response to allergen/drug cross-linking IgE activation through the measurement of activation markers (such as CD63, CD203c) by flow cytometry. Read More

View Article and Full-Text PDF

Anaphylactic risk related to omalizumab, benralizumab, reslizumab, mepolizumab, and dupilumab.

Clin Transl Allergy 2021 Jun 3;11(4):e12038. Epub 2021 Jun 3.

Department of Pharmacy Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China.

Background: Monoclonal antibodies (mAbs) are novel, effective therapeutics for the treatment of inadequately controlled severe asthma. Knowledge of the anaphylaxis risks related to different mAbs is essential for their appropriate and safe administration. This study aimed to evaluate the associations between different mAbs and anaphylactic reactions by applying statistical approaches to pharmacovigilance data. Read More

View Article and Full-Text PDF

Research on Characteristic of Chronic Spontaneous Urticaria Based on Multiscale Entropy.

Comput Math Methods Med 2021 25;2021:6691356. Epub 2021 May 25.

College of Mathematical Sciences, Harbin Engineering University, Harbin 150001, China.

Chronic spontaneous urticaria (CSU) is a common skin disease which symptom is local pruritus and pain. In medicine, researchers take a certain point that the brain is the control center of CSU, but in previous experiments, the researchers found that cerebellum also had a certain effect on CSU. In order to find out the influence of CSU in the brain and cerebellum, we collected the brain resting-state fMRI data from 40 healthy controls and 32 CSU patients and used DPABI to preprocess. Read More

View Article and Full-Text PDF

In Chronic Spontaneous Urticaria, Comorbid Depression Linked to Higher Disease Activity, and Substance P Levels.

Front Psychiatry 2021 26;12:667978. Epub 2021 May 26.

Department of Dermatology, Koç University School of Medicine, Istanbul, Turkey.

Patients with chronic spontaneous urticaria often exhibit psychiatric comorbidities including depression that contribute to the impairment of their quality of life. How CSU and depression are linked isn't well-understood. Substance P has been shown to be increased in patients with CSU and is held to contribute to the pathogenesis of depression. Read More

View Article and Full-Text PDF

On the binding reaction of loratadine with human serum acute phase protein alpha 1-acid glycoprotein.

J Biomol Struct Dyn 2021 Jun 14:1-8. Epub 2021 Jun 14.

Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India.

Loratadine is an important anti-allergic drug. It is a second generation antihistamine drug used to treat allergic rhinitis, hay fever and urticaria. Human serum alpha 1-acid glycoprotein (AG) is an important acute phase protein and its serum concentration is found to increase in inflammation and acute response. Read More

View Article and Full-Text PDF

Bullous eosinophilic annular erythema.

Dermatol Online J 2021 May 15;27(5). Epub 2021 May 15.

National Skin Centre.

Eosinophilic annular erythema is an idiopathic acute eosinophilic dermatosis. It is a rare condition, with approximately 30 cases reported in the English literature. It features annular, figurate urticarial edematous plaques primarily affecting the trunk and proximal limbs. Read More

View Article and Full-Text PDF

Lipid transfer protein syndrome due to wild grape juice and various vegetables: A life-threatening food allergen.

J Dermatol 2021 Jun 11. Epub 2021 Jun 11.

Department of Dermatology, Iwate Medical University School of Medicine, Shiwa-gun, Japan.

We report a 16-year-old Japanese male with mugwort pollinosis in whom ingestion of wild grape juice and various vegetables caused recurrent general urticaria, abdominal pain, dyspnea, and loss of consciousness. A skin prick test demonstrated positive reactions to a wide variety of both non-heated and heated vegetables and fruits such as wild grape, bell pepper, onion, Chinese cabbage, tomato, eggplant, and broccoli. The serum immunoglobulin E levels (ImmunoCAP ISAC ) for Art v 3, Pla a 3, Pru p 3, and Jug r 3, which are lipid transfer protein (LTP) homologs, were positive but those for Bet v 1 and Bet v 2 were negative. Read More

View Article and Full-Text PDF

Cryoglobulins, Cryofibrinogens, and Cold Agglutinins in Cold Urticaria: Literature Review, Retrospective Patient Analysis, and Observational Study in 49 Patients.

Front Immunol 2021 25;12:675451. Epub 2021 May 25.

Department of Dermatology and Allergy, Dermatological Allergology, Allergie-Centrum-Charité, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.

Introduction: Cryoproteins, such as cryoglobulins, cryofibrinogens and cold agglutinins, precipitate at low temperatures or agglutinate erythrocytes and dissolve again when warmed. Their pathogenetic and diagnostic importance in cold urticaria (ColdU) is unclear. In this study, we aimed to characterize the prevalence of cryoproteins in patients with ColdU. Read More

View Article and Full-Text PDF

Reply to "Proposal for a new classification of vibratory urticaria/angioedema".

J Allergy Clin Immunol Pract 2021 Jun;9(6):2543-2544

Dermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Berlin, Germany (corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany. Electronic address:

View Article and Full-Text PDF

Proposal for a new classification of vibratory urticaria/angioedema.

J Allergy Clin Immunol Pract 2021 Jun;9(6):2542-2543

Dermatology Department, Hospital del Mar IMIM, Universitat Autònoma, Barcelona, Spain.

View Article and Full-Text PDF

Comparing Antihistamines in Chronic Spontaneous Urticaria: Possible Future Directions.

J Allergy Clin Immunol Pract 2021 Jun;9(6):2272-2273

Médica Sur, Clinical Foundation and Hospital, Mexico City, Mexico; Center of Excellence in Asthma and Allergy, Mexico City, Mexico. Electronic address:

View Article and Full-Text PDF

The Road to Better Urticaria and Angioedema Management.

J Allergy Clin Immunol Pract 2021 Jun;9(6):2243-2244

Dermatological Allergology, Allergie-Centrum-Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. Electronic address:

View Article and Full-Text PDF

What's New in the Treatment of Urticaria and Angioedema.

J Allergy Clin Immunol Pract 2021 Jun;9(6):2170-2184

Department for Children and Adolescents, University Hospital Frankfurt, Goethe University, Theodor-Stern-Kai 7, Frankfurt, Germany.

Chronic urticaria and angioedema are diseases often managed by Allergy and Immunology specialists. Recent international guidelines have outlined a stepwise approach to management of patients using dose escalation of second-generation antihistamines followed by use of omalizumab and finally cyclosporine in more refractory cases. In select patients (those with refractory chronic urticaria), nonbiologic alternative medications with anti-inflammatory or immunosuppressant activity may be considered. Read More

View Article and Full-Text PDF

Triggers of Exacerbation in Chronic Urticaria and Recurrent Angioedema-Prevalence and Relevance.

J Allergy Clin Immunol Pract 2021 Jun;9(6):2160-2168

Clinical Faculty, University of Texas Southwestern Medical School, Allergy and Asthma Specialists, Dallas, Texas. Electronic address:

Patients with urticaria and angioedema often have triggers that cause an outbreak or a swelling episode or worsen their chronic condition. Exploring these factors with each patient may result in better understanding and control of their disease. Patients should be advised to avoid known triggers, if feasible, or prepare to prevent or control an exacerbation with appropriate pretreatment if avoidance is not possible. Read More

View Article and Full-Text PDF

How to Measure Disease Activity, Impact, and Control in Patients with Recurrent Wheals, Angioedema, or Both.

J Allergy Clin Immunol Pract 2021 Jun;9(6):2151-2157

Division of Clinical Immunology and Allergy, Department of Medicine, McMaster University, Hamilton, ON, Canada.

Chronic spontaneous urticaria and chronic inducible urticaria are characterized by wheals, angioedema, or both, whereas other conditions such as hereditary angioedema present only with angioedema. The unpredictability of outbreaks, disfigurement, pruritus, and associated sleep and work disturbance can cause a significant impact on quality of life (QoL). Significant breakthroughs in the understanding of these conditions in recent years have led to the development of novel therapies. Read More

View Article and Full-Text PDF

Results of two Phase 1, Randomized, Double-blind, Placebo-controlled, Studies (Ascending Single-Dose and Multiple-Dose Studies) to Determine the Safety, Tolerability, and Pharmacokinetics of Orally Administered LX9211 in Healthy Participants.

Clin Ther 2021 Jun 6. Epub 2021 Jun 6.

Lexicon Pharmaceuticals Inc, The Woodlands, Texas. Electronic address:

Purpose: For neuropathic pain, current therapies do not provide relief for most patients; less than half achieve a 50% pain reduction. Current analgesics have adverse effects. We present 2 Phase I studies of LX9211, a new small-molecule AP2-associated kinase 1 inhibitor with preclinical effectiveness in pain relief. Read More

View Article and Full-Text PDF

Chronic urticaria in the real-life clinical practice setting in Portugal: 2-years results from the non-interventional multicenter AWARE study.

Acta Med Port 2021 Jun 9. Epub 2021 Jun 9.

Serviço de Imunoalergologia. Centro Hospitalar de Vila Nova de Gaia/Espinho. Vila Nova de Gaia. Portugal.

Introduction: Information regarding chronic urticaria patients in the real-world setting is scarce. This analysis reports the two-year results of Portuguese patients included in the AWARE study.

Material And Methods: Non-interventional cohort study. Read More

View Article and Full-Text PDF

Retrospective Study of Clinico-Aetiological Factors of Chronic Urticaria Among Children Attending a Tertiary Care Paediatric Centre in Eastern Province of Sri Lanka.

Cureus 2021 May 4;13(5):e14848. Epub 2021 May 4.

Paediatrics, Paediatric Professorial Unit, Teaching Hospital, Batticaloa, LKA.

Introduction Chronic urticaria is one of the growing problems worldwide and the prevalence is increasing. Around 2% of children have been shown to be affected with chronic urticaria. Objectives To evaluate demographic, clinical and aetiological factors related to chronic urticaria in children and to assess investigations and treatment. Read More

View Article and Full-Text PDF

Characteristics of patients with chronic spontaneous urticaria showing early and complete responses to omalizumab.

Ann Allergy Asthma Immunol 2021 Jun 5. Epub 2021 Jun 5.

Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

View Article and Full-Text PDF

Knowledge, attitudes, and practices associated with personal health care on urticaria in peripheral health facilities of Yaoundé, Cameroon (Sub-Saharan Africa).

Int J Dermatol 2021 Jun 8. Epub 2021 Jun 8.

Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.

Background: Urticaria is an acute or chronic inflammatory dermatosis that is characterized by erythematous, edematous, itchy, and transient urticarial plaques that cover the skin and mucous membranes. The aim of this study was to evaluate the knowledge of consulting staff on urticaria in Yaoundé, Cameroon, as well as the attitudes and practices resulting from it.

Methods: We conducted a descriptive cross-sectional study. Read More

View Article and Full-Text PDF

Anaphylaxis after consumption of pumpkin seeds in a 2-y-old child tolerant to its pulp: A case study.

Nutrition 2021 Apr 20;89:111272. Epub 2021 Apr 20.

Department of Pediatrics, Allergology and Gastroenterology, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Poland.

Objectives: Pumpkin and its seeds are increasingly consumed by children for their potential health benefits. Each day, approximately 30% of teenagers consume nuts and seeds, including pumpkin seeds. However, there is some evidence that pumpkin seeds may exert allergenic effects and induce severe life-threatening anaphylaxis. Read More

View Article and Full-Text PDF

Serum level of hemokinin-1 is significantly lower in patients with chronic spontaneous urticaria than in healthy subjects.

Allergol Int 2021 Jun 2. Epub 2021 Jun 2.

Allergy and Immunology Research Project Team, Nihon University School of Medicine, Tokyo, Japan; Center for Medical Education, Nihon University School of Medicine, Tokyo, Japan; Center for Allergy, Nihon University Itabashi Hospital, Tokyo, Japan. Electronic address:

Background: We previously reported upregulation of expression of Mas-related G protein-coupled receptor X2 (MRGPRX2) on mast cells (MCs) in the skin of patients with severe chronic spontaneous urticaria (CSU). Serum levels of substance P (SP) were reportedly significantly elevated, in correlation with the severity of CSU. Hemokinin-1 (HK-1) reportedly induced histamine release from LAD2 cells via MRGPRX2. Read More

View Article and Full-Text PDF

Study of Minimal Erythema Dose in a Series of Solar Urticaria.

Actas Dermosifiliogr 2021 Jun 1;112(6):546-550. Epub 2021 Feb 1.

Departamento de Dermatología, Hospital Universitario de La Princesa, Madrid, Spain.

Background: Reduced minimal erythema dose (MED) is an abnormal erythematous reaction to light according to the skin phototype, which is determined by phototest. MED is reduced or abnormal in some photodermatoses. However, we have not found information about reduced MED in patients with solar urticarial (SU), a condition which causes hives after sun exposure. Read More

View Article and Full-Text PDF

Erratum to "Skin Biopsy in Chronic Urticaria: When and Where and What to Look for?"

Actas Dermosifiliogr 2021 Jun;112(6):570-571

Servicio de Dermatología del Hospital General de Alicante, Alicante, España.

View Article and Full-Text PDF

Urticarial vasculitis: A Complication of SMZ-TMP therapy.

Clin Case Rep 2021 May 9;9(5):e03872. Epub 2021 Apr 9.

Department of Dermatology Mayo Clinic Florida Jacksonville FL USA.

Recognize that delayed hypersensitivity reactions to sulfonamides may present as urticated plaques with hyperpigmentation and purpura for which a diagnosis of urticarial vasculitis should be considered. Read More

View Article and Full-Text PDF

Urticaria as a manifestation of hyperthyroidism.

Clin Case Rep 2021 May 5;9(5):e03620. Epub 2021 May 5.

Tameside and Glossop Integrated Care NHS Foundation Trust Ashton-Under-Lyne UK.

In clinically euthyroid patients presenting with urticaria, a trial period of withholding antithyroid medications can be exercised. In clinically hyperthyroid patients, antithyroid medications may be stopped with close observation of response. Read More

View Article and Full-Text PDF

Uncommon urticaria.

Arch Dis Child Educ Pract Ed 2021 Jun 3. Epub 2021 Jun 3.

Pediatric Department, Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy.

View Article and Full-Text PDF

Passive immune basophil activation test for the identification of allergic episodes from various adverse events elicited by haematopoietic cell transplantation: A pilot study.

Vox Sang 2021 Jun 3. Epub 2021 Jun 3.

Research and Development, Japanese Red Cross Kinki Block Blood Center, Ibaraki, Japan.

Background And Objectives: Haematopoietic cell transplantation (HCT) therapy tends to be associated with various complications including engraftment failure, regimen-related toxicities, and infectious diseases. In addition, HC infusion itself occasionally elicits adverse events (AEs), one of the most common AEs is an allergic reaction. As appropriate laboratory tests have not yet been established to distinguish allergy-mediated AEs from other complications, clinical responses for HCT-related AEs can only be nonspecific. Read More

View Article and Full-Text PDF