22,039 results match your criteria Urticaria


Rostrum: Itching as a systemic disease.

J Allergy Clin Immunol 2019 Apr 17. Epub 2019 Apr 17.

Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery and Miami Itch Center Miller School of Medicine University of Miami, Miami, FL. Electronic address:

Pruritus is a sensation that emanates from the skin and is transferred via peripheral nerve fibers to the central nervous system. It is easily understood that primary skin disorders such as atopic eczema, skin dryness, psoriasis, and urticaria can elicit pruritus. However certain systemic diseases can cause chronic pruritus that have significant impact on patients' quality of life. Read More

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http://dx.doi.org/10.1016/j.jaci.2019.04.005DOI Listing

Food Allergen Sensitisation Patterns in Omani Patients with Allergic Manifestations.

Sultan Qaboos Univ Med J 2018 Nov 28;18(4):e483-e488. Epub 2019 Mar 28.

Department of Microbiology, Sultan Qaboos University Hospital, Muscat, Oman.

Objectives: This study aimed to evaluate the relationship between food allergen sensitisation patterns and allergic manifestations in Omani patients and highlight the importance of specific immunoglobulin E (IgE) testing.

Methods: This retrospective study included all patients referred due to allergic manifestations to the Sultan Qaboos University Hospital (SQUH), Muscat, Oman, from November 2012 to November 2016. Specific IgE blood testing was performed to determine sensitisation to common foods known to cause allergic reactions. Read More

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https://journals.squ.edu.om/index.php/squmj/article/view/299
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http://dx.doi.org/10.18295/squmj.2018.18.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443266PMC
November 2018
2 Reads

An Observational Study to Describe the Clinical Pattern of Dermatological Emergencies from Emergency Department and Intensive Care Unit: Our Experience from a Tertiary Care Hospital in Northern India.

Indian Dermatol Online J 2019 Mar-Apr;10(2):144-148

Department of Dermatology, MLN Medical College, Allahabad, Uttar Pradesh, India.

Background: A large number of skin diseases have the potential to culminate into potentially fatal "acute skin failure." The concept of dermatological intensive care unit (ICU) has largely evolved as a result of increased number of emergencies encountered by dermatologists these days. Dermatological emergencies comprise 8-20% of cases presenting to the emergency department. Read More

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http://dx.doi.org/10.4103/idoj.IDOJ_318_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434742PMC
April 2019
2 Reads

Autoimmune Theories of Chronic Spontaneous Urticaria.

Front Immunol 2019 29;10:627. Epub 2019 Mar 29.

Department of Immunology, Duke University Medical Center, Durham, NC, United States.

Urticaria (hives) is a highly prevalent skin disorder that can occur with or without associated angioedema. Chronic spontaneous urticaria (CSU) is a condition which persists for more than 6 weeks in duration and occurs in the absence of an identifiable provoking factor. CSU results from pathogenic activation of mast cells and basophils, which gives rise to the release of proinflammatory mediators that support the generation of urticaria. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450064PMC
March 2019
2 Reads

Awareness of Family Physicians Towards Antihistamines.

Indian J Dermatol 2019 Mar-Apr;64(2):112-114

Department of Dermatology, Dr. D.Y. Patil School of Medicine, Mumbai, Maharashtra, India.

Background: Antihistamines are one of the commonly prescribed groups of drugs for allergic disorders and pruritus. They are broadly grouped into two generations, the second-generation ones being more effective and with less side effects. The family physicians frequently use antihistamines as patients contact them initially for their problem. Read More

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http://dx.doi.org/10.4103/ijd.IJD_325_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440187PMC
April 2019
1 Read

An unexpected challenging airway: Urticaria factitia caused difficult mask ventilation and tracheal intubation.

J Clin Anesth 2019 Apr 10;57:116. Epub 2019 Apr 10.

Duzce University Faculty of Medicine, Neurosurgery Department, Duzce, Turkey.

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http://dx.doi.org/10.1016/j.jclinane.2019.04.002DOI Listing
April 2019
1 Read

Serum levels of brain-derived neurotrophic factor in patients with acne vulgaris.

J Cosmet Dermatol 2019 Apr 13. Epub 2019 Apr 13.

Department of Dermatology and Andrology, Faculty of Medicine, Benha University, Benha, Egypt.

Background: Many dermatological diseases have a great impact on the psychological state of patients, like urticaria, psoriasis, atopic dermatitis, and acne vulgaris. Finding a "gold standard" biomarker for chronic stress in acne patients is challenging because of the complex etiology of the chronic stress and its variable manifestations.

Aims: The aim of this study was to evaluate the correlation between serum levels of BDNF and the presence and severity of acne vulgaris and to assess the relationship of this biomarker to both the degree of psychological stress and the quality of patients' lives (QoL). Read More

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http://dx.doi.org/10.1111/jocd.12940DOI Listing
April 2019
5 Reads

Exceptional association of hypocomplementemic urticarial vasculitis syndrome (HUVS) and symptomatic pulmonary histoplasmosis: a case-based literature review.

Clin Rheumatol 2019 Apr 13. Epub 2019 Apr 13.

Departments of Medicine and Rheumatology, MetroHealth Medical Center, Cleveland, OH, USA.

Hypocomplementemic urticarial vasculitis syndrome (HUVS) is a rare type III hypersensitivity disorder characterized by urticarial vasculitis and prolonged hypocomplementemia. Individuals with HUVS may also have joint involvement, pulmonary manifestations, ocular disease, kidney inflammation, or any other form of organ involvement. Hypocomplementemia, the presence of C1q antibody in the serum, and urticarial vasculitis are the keys to the diagnosis of HUVS. Read More

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http://dx.doi.org/10.1007/s10067-019-04548-8DOI Listing
April 2019
1 Read

Ebastine in the treatment of allergic rhinitis and urticaria: 30 years of clinical studies and real-world experience.

Authors:
J Sastre

J Investig Allergol Clin Immunol 2019 Apr 12. Epub 2019 Apr 12.

Department of Allergy, Fundación Jimenez Diaz, Madrid. CIBERES, Instituto Carlos III. Department of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.

Histamine, acting predominantly via the H1-receptor, is an important mediator of the symptoms of allergy, and H1-antihistamines, which stabilise the receptor in its inactive form, are the treatment of choice for some chronic allergic conditions. Ebastine is a well-established oral second-generation H1-antihistamine. It is administered once daily at a dose of 10-20 mg and is available as a standard tablet and also as a fast-dissolving tablet that disintegrates in the mouth. Read More

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http://dx.doi.org/10.18176/jiaci.0401DOI Listing
April 2019
1 Read

[Anaphylactic shock secondary to the use of macrogol 4000 as a bowel cleanser:a case report].

Nihon Shokakibyo Gakkai Zasshi 2019 ;116(4):330-335

Department of Gastroenterology and Hepatology, Itami City Hospital.

A 44-year-old man was administered Niflec containing macrogol 4000 as a bowel cleanser for colonoscopic examination. Immediately after ingestion, he experienced oral cavity discomfort and nasal congestion, followed by acute urticaria and presyncope. His systolic blood pressure and peripheral capillary oxygen saturation dropped to 66mmHg and 89%, respectively. Read More

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http://dx.doi.org/10.11405/nisshoshi.116.330DOI Listing
January 2019
1 Read

Skin and Systemic Inflammation in Schnitzler's Syndrome Are Associated With Neutrophil Extracellular Trap Formation.

Front Immunol 2019 22;10:546. Epub 2019 Mar 22.

Department of Dermatology and Allergy, Allergie-Centrum-Charité, Berlin Institute of Health, Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.

Schnitzler's syndrome is a rare autoinflammatory disorder characterized by interleukin-1ß-mediated and neutrophil-dominated inflammation. Neutrophil extracellular traps (NETs) are web-like structures of decondensed chromatin, histones, and antimicrobial peptides released by neutrophils. NETs were initially described in the context of pathogen defense but are also involved in autoimmune-mediated skin diseases. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438918PMC
March 2019
1 Read

Use of the Patient Benefit Index to monitor treatment of chronic spontaneous urticaria with omalizumab.

Dermatol Ther 2019 Apr 9:e12902. Epub 2019 Apr 9.

Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark.

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http://dx.doi.org/10.1111/dth.12902DOI Listing
April 2019
2 Reads

Morbidity Associated with Chronic Infection: A Systematic Review and Meta-Analysis.

Am J Trop Med Hyg 2019 Apr 8. Epub 2019 Apr 8.

IRCCS Sacro Cuore Don Calabria Hospital, Verona, Italy.

, a worldwide-distributed soil-transmitted helminth, causes chronic infection which may be life threatening. Limitations of diagnostic tests and nonspecificity of symptoms have hampered the estimation of the global morbidity due to strongyloidiasis. This work aimed at assessing -associated morbidity through a systematic review and meta-analysis of the available literature. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0895DOI Listing
April 2019
2 Reads

Cold-induced urticaria in a child with familial Mediterranean fever.

J Allergy Clin Immunol Pract 2019 Apr;7(4):1376

Division of Allergy and Clinical Immunology, Department of Pediatrics, University of Health Sciences, Ankara Health Research and Application Center, Ankara, Turkey.

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https://linkinghub.elsevier.com/retrieve/pii/S22132198193007
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http://dx.doi.org/10.1016/j.jaip.2019.01.019DOI Listing
April 2019
4 Reads

A step beyond the hygiene hypothesis-immune-mediated classes determined in a population-based study.

BMC Med 2019 Apr 9;17(1):75. Epub 2019 Apr 9.

Department of Psychiatry, Center for Research in Psychiatric Epidemiology and Psychopathology, Lausanne University Hospital, Prilly, Switzerland.

Background: Comorbidity patterns of childhood infections, atopic diseases, and adverse childhood experiences (ACE) are related to immune system programming conditions. The aim of this study was to make a step beyond the hygiene hypothesis and to comprehensively classify these patterns with latent class analysis (LCA). A second aim was to characterize the classes by associations with immunological, clinical, and sociodemographic variables. Read More

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http://dx.doi.org/10.1186/s12916-019-1311-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454751PMC
April 2019
1 Read
7.249 Impact Factor

The use of omalizumab for treatment-refractory chronic spontaneous urticaria in a West Australian outpatient cohort.

Intern Med J 2019 Apr;49(4):526-528

Immunology Department, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.

There is a lack of real-world data on the use of omalizumab in treatment-refractory chronic spontaneous urticaria (CSU). A single-centre retrospective cohort study was performed to assess the efficacy and safety of omalizumab for treatment-refractory CSU. The overall response rate of 67% is comparable with that reported in the literature. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/imj.14245
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http://dx.doi.org/10.1111/imj.14245DOI Listing
April 2019
1 Read

Triggering atrial fibrillation after omalizumab injection in a patient with chronic spontaneous urticarial. A case report.

Authors:
Songul Cildag

Med Pharm Rep 2019 Jan 15;92(1):91-93. Epub 2019 Jan 15.

Immunology-Allergy Department, Adnan Menderes University, Turkey.

Introduction: Omalizumab is recommended as a third-line treatment in the treatment of chronic spontaneous urticaria. During omalizumab use, which has high efficacy and safety, the side effects observed are usually moderate and temporary. Here we discuss the triggering of atrial fibrillation following omalizumab injection. Read More

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http://dx.doi.org/10.15386/cjmed-1082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448490PMC
January 2019
1 Read

Hypersensitivity reactions to antiepileptic drugs in children.

Pediatr Allergy Immunol 2019 Apr 5. Epub 2019 Apr 5.

University of Belgrade-Faculty of Medicine, Belgrade, Serbia.

Background: Antiepileptic drugs (AEDs) can cause hypersensitivity reactions in children. These reactions are mainly cutaneous, self-limiting and benign but life-threatening severe cutaneous adverse reactions can occur. Infections can lead to skin eruptions and mimic drug hypersensitivity reactions, if a drug is taken at the same time. Read More

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http://dx.doi.org/10.1111/pai.13055DOI Listing
April 2019
2 Reads

The incidence of lidocaine allergy in dentists: an evaluation of 100 general dental practitioners.

Int J Occup Med Environ Health 2019 Apr 2. Epub 2019 Apr 2.

Medical University of Lodz, Łódź, Poland (Department of Oral Surgery).

Objectives: Local anesthetics are some of the most common drugs used in dentistry and about 6 million people daily around the world are subjected to their effect in procedures performed by a similar number of dentists who, in turn, are usually not aware of the fact of being allergic to this group of medications. Assuming that dentists are also patients, and that in their daily practice the contact with the allergen is very frequent, it is essential to assess the incidence of allergy to lidocaine in general dental practitioners.

Material And Methods: The authors evaluated a group of 100 general dental practitioners in whom adverse reactions similar to anaphylaxis occurred after local anesthesia. Read More

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http://www.journalssystem.com/ijomeh/Incidence-of-lidocaine-
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http://dx.doi.org/10.13075/ijomeh.1896.01235DOI Listing
April 2019
3 Reads

Investigation into the α-Gal syndrome: Characteristics of 261 children and adults reporting red meat allergy.

J Allergy Clin Immunol Pract 2019 Mar 30. Epub 2019 Mar 30.

Division of Allergy & Clinical Immunology, University of Virginia, Charlottesville, VA. Electronic address:

Background: Red meat allergy has historically been understood as a rare disease of atopic children but the discovery of the 'α-Gal syndrome', which relates to IgE to the oligosaccharide galactose-α-1,3-galactose (α-Gal), has challenged that notion.

Objective: To describe the clinical and immunologic characteristics of a large group of subjects with self-reported allergy to mammalian meat.

Methods: This was an observational study of 261 children and adults (range 5-82 years) who presented for evaluation for allergic reactions to mammalian meat. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.03.031DOI Listing
March 2019
3 Reads

Wheat allergy in patients with recurrent urticaria.

World Allergy Organ J 2019 8;12(2):100013. Epub 2019 Mar 8.

Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, China.

Background: Clinical observation revealed that most of wheat-induced anaphylaxis (WIA)/wheat-dependent exercise-induced anaphylaxis (WDEIA) patients showed a history of recurrent urticaria. We aim to determine the association between recurrent urticaria and anaphylaxis in wheat allergy.

Methods: Population-based cohort study involved patients with WIA (n = 193, including WDEIA n = 104), recurrent urticaria (n = 177), non-wheat-related anaphylaxis (n = 584), atopic disease (excluding anaphylaxis, n = 221) and healthy control (n = 95) from 2009 to 2016. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19394551193010
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http://dx.doi.org/10.1016/j.waojou.2019.100013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439404PMC
March 2019
7 Reads

Learnings from real-life experience of using omalizumab for chronic urticaria in Latin America.

World Allergy Organ J 2019 23;12(2):100011. Epub 2019 Feb 23.

Respiralab, Respiralab Research Group, Guayaquil, Ecuador.

Background: Updated urticaria guidelines recommend that patients should be assessed for disease activity, severity, control, and quality of life at baseline and follow up. Regarding treatment, guidelines consider second generation antihistamines as the cornerstone in therapy for chronic urticaria (CU), while other drugs, such as omalizumab, are conceived as second-line alternatives. In regards to omalizumab, despite advances in the management of CU, there are still open questions about timing, dosing, and objective measures for clinical response. Read More

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http://dx.doi.org/10.1016/j.waojou.2019.100011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439401PMC
February 2019
4 Reads

Validation of the Turkish version of the Urticaria Control Test: Correlation with other tools and comparison between spontaneous and inducible chronic urticaria.

World Allergy Organ J 2019 26;12(1):100009. Epub 2019 Jan 26.

Dermatological Allergology, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Germany.

Background: The urticaria control test (UCT) is a questionnaire designed to determine if chronic urticaria (CU) is controlled or not and to aid therapeutic decision-making. It collects retrospective information about the symptoms and quality of life impairment over the last 4 weeks. The current study aimed to investigate the validity, reliability and sensitivity to change of the Turkish version of the UCT. Read More

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http://dx.doi.org/10.1016/j.waojou.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439411PMC
January 2019
2 Reads

European S2k Guideline on Chronic Pruritus.

Acta Derm Venereol 2019 Apr;99(5):469-506

Occupational Dermatology, Department of Dermatology, Ruprecht-Karls University Heidelberg, Voßstr. 2, DE-69115 Heidelberg, Germany. E-mail:

Pruritus is a frequent symptom in medicine. Population-based studies show that every 5th person in the general population has suffered from chronic pruritus at least once in the lifetime with a 12-month incidence of 7%. In patient populations its frequency is much higher depending on the underlying cause, ranging from around 25% in haemodialysis patients to 100% in skin diseases such as urticaria and atopic dermatitis (AD). Read More

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http://dx.doi.org/10.2340/00015555-3164DOI Listing
April 2019
2 Reads

Bias in the use of a SSC/CCR3 gate to capture basophils in chronic urticaria?

Immunobiology 2019 Mar 23. Epub 2019 Mar 23.

Azienda Ospedaliera Universitaria Integrata (AOUI), Section Immunology, Verona, Italy.

A comment on D'Auria E., De Amici M., Licari A. Read More

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http://dx.doi.org/10.1016/j.imbio.2019.03.003DOI Listing
March 2019
2 Reads
3.044 Impact Factor

Disease burden in patients with asthma before initiating biologics: A retrospective cohort database study.

Allergy Asthma Proc 2019 Mar 29. Epub 2019 Mar 29.

Background: Real-world data on the characteristics and burden of disease among patients with asthma before receiving asthma-specific biologics would improve the understanding of the use of these therapies in a clinical setting. Currently, limited data are available on the use of mepolizumab and omalizumab for the treatment of asthma.

Objective: To determine the characteristics and disease burden among patients with asthma before initiating treatment withmepolizumab or omalizumab. Read More

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http://dx.doi.org/10.2500/aap.2019.40.4220DOI Listing
March 2019
1 Read

Evaluation of nine patients with solar urticaria during summer.

G Ital Dermatol Venereol 2019 Mar 29. Epub 2019 Mar 29.

Allergological and Occupational Dermatology Unit, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy.

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http://dx.doi.org/10.23736/S0392-0488.19.06176-5DOI Listing
March 2019
1 Read

Chronic Urticaria: An Overview of Treatment and Recent Patents.

Recent Pat Inflamm Allergy Drug Discov 2019 Mar 28. Epub 2019 Mar 28.

The Institute of Integrative Medicine, The Chinese University of Hong Kong, Shatin. Hong Kong.

Background: Up to 1% of the general population in the USA and Europe have chronic urticaria (CU) at some point in their lifetime. CU has an adverse effect on quality of life.

Objective: To provide an update on the epidemiology, pathogenesis, clinical manifestations, diagnosis, aggravating factors, complications, treatment and prognosis of CU. Read More

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http://dx.doi.org/10.2174/1872213X13666190328164931DOI Listing
March 2019
1 Read

Drug reaction with eosinophilia and systemic symptoms in a cohort of Asian children.

Pediatr Dermatol 2019 Mar 28. Epub 2019 Mar 28.

Dermatology Service, KK Women's and Children's Hospital, Singapore, Singapore.

Background/objectives: Drug reaction with eosinophilia and systemic symptoms (DRESS) is rare but potentially fatal in children. Fever and rash, which are salient features of DRESS, may mimic other commonly encountered pediatric conditions. We profiled the DRESS cases in a tertiary children's hospital in Singapore. Read More

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http://dx.doi.org/10.1111/pde.13812DOI Listing
March 2019
1 Read

Anaesthetic management of patients with pre-existing allergic conditions: a narrative review.

Br J Anaesth 2019 Mar 12. Epub 2019 Mar 12.

Department of Anaesthesia and Peri-operative Medicine, Auckland City Hospital, Auckland, New Zealand.

This narrative review seeks to distinguish the clinical patterns of pre-existing allergic conditions from other confounding non-allergic clinical entities, and to identify the potential related risks and facilitate their perioperative management. Follow-up investigation should be performed after a perioperative immediate hypersensitivity to establish a diagnosis and provide advice for subsequent anaesthetics, the main risk factor for perioperative immunoglobulin E (IgE)-mediated anaphylaxis being a previous uninvestigated perioperative immediate hypersensitivity reaction. The concept of cross-reactivity between drugs used in the perioperative setting and food is often quoted, but usually not supported by evidence. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00070912193006
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http://dx.doi.org/10.1016/j.bja.2019.01.020DOI Listing
March 2019
7 Reads

Allergic Reaction to Intravenous Atropine in a Patient with Organophosphate Poisoning.

J Res Pharm Pract 2019 Jan-Mar;8(1):33-34

Department of Clinical Toxicology, Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Atropine is a drug of choice for muscarinic effects in organophosphate (OP) poisoning. Allergic reaction to atropine is rare. Here, we report a case of a 17-year-old male who was admitted with clinical manifestations of acute OP poisoning. Read More

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http://dx.doi.org/10.4103/jrpp.JRPP_18_83DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400035PMC
March 2019
1 Read

Spontaneous cutaneous adverse drug reaction reports-An analysis of a 10-year dataset in Singapore.

Pharmacol Res Perspect 2019 04 13;7(2):e00469. Epub 2019 Mar 13.

Department of Pharmacy Faculty of Science National University of Singapore Singapore Singapore.

We analyzed the spontaneous adverse event database in Singapore to determine the types of cutaneous adverse drug reactions (CADRs) and causative drugs reported. We selected 10 CADRs-of-interest, and identified the suspected drugs and the characteristics of the at-risk population. ADR reports received from 2006 to 2015 of the system organ class "Skin and Appendages Disorders" were analyzed based on patient demographics, the types of CADRs, suspected drugs, outcome, and latency period. Read More

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http://dx.doi.org/10.1002/prp2.469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415979PMC
April 2019
2 Reads

Tumor necrosis factor-alpha and Fas/Fas ligand signaling pathways in chronic spontaneous urticaria.

Allergy Asthma Clin Immunol 2019 14;15:15. Epub 2019 Mar 14.

1Clinical Department of Internal Diseases, Dermatology and Allergology, SMDZ in Zabrze, Medical University of Silesia in Katowice, ul. M. Curie-Skłodowskiej 10, 41-800 Zabrze, Poland.

Background: There is increasing evidence pointing to the important role of tumor necrosis factor-alpha (TNF-α), a key inflammatory and apoptotic mediator in urticarial inflammation. However, the role of the TNF-α system and Fas/Fas ligand (FasL) in the apoptosis-inducing pathways in chronic spontaneous urticaria (CSU), remain unclear.

Aim: To determine circulating concentrations of TNF-α, soluble TNF-α receptor type 1 and type 2 (sTNF-R1 and sTNF-R2, respectively) as well as soluble Fas (sFas) and FasL (sFasL) in CSU subjects. Read More

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https://aacijournal.biomedcentral.com/articles/10.1186/s1322
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http://dx.doi.org/10.1186/s13223-019-0332-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417283PMC
March 2019
5 Reads

Eosinophils mediate basophil-dependent allergic skin inflammation in mice.

J Invest Dermatol 2019 Mar 22. Epub 2019 Mar 22.

Department of Infection Biology, University Hospital Erlangen and Friedrich-Alexander University Erlangen-Nuremberg (FAU), 91054 Erlangen, Germany. Electronic address:

The mechanisms leading to allergic skin inflammation such as atopic dermatitis or urticaria are poorly defined. Here, we used a mouse model for IgE-dependent chronic allergic inflammation (IgE-CAI) to study the role of basophils and eosinophils for induction of pathology. FcεRI expression in basophils was required for the ear swelling response and basophils promoted the expression of eosinophil recruiting chemokines in the ear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0022202X193133
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http://dx.doi.org/10.1016/j.jid.2019.03.1129DOI Listing
March 2019
3 Reads

[What is neutrophilic urticaria?]

Ann Dermatol Venereol 2019 Mar 23. Epub 2019 Mar 23.

Service de dermatologie et d'allergologie, HUEP, Sorbonne Universités, hôpital Tenon, AP-HP, 4, rue de la Chine, 75020 Paris, France; Inserm U1135, centre d'immunologie et des maladies infectieuses - Paris (Cimi-Paris), 75013 Paris, France.

Some debate continues to surround the existence of neutrophilic urticaria (NU) as a nosological entity. Certain authors consider NU as a banal form of urticaria since an infiltrate predominantly made up of polynuclear neutrophils (PNN) is seen in certain cases of chronic and acute urticaria. Moreover, it has been stated that the histological appearance of chronic urticaria varies according to the time between appearance of the plaque and the performance of biopsy: the presence of PNN may occur later. Read More

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http://dx.doi.org/10.1016/j.annder.2019.01.019DOI Listing
March 2019
2 Reads

Association of positive and negative autologous serum skin test responses with clinical features of chronic spontaneous urticaria in Asian patients: A systematic review and meta-analysis.

Exp Ther Med 2019 Apr 13;17(4):2603-2613. Epub 2019 Feb 13.

Department of Dermatology, No. 1 Hospital of China Medical University and Key Laboratory of Immunodermatology, Ministry of Health and Ministry of Education, Shenyang, Liaoning 110001, P.R. China.

Previous studies on the correlation between positive autologous serum skin test (ASST) responses and the clinical features of patients with chronic spontaneous urticaria (CSU) have provided conflicting results. To evaluate the significance of ASST responses in CSU, a variety of databases were searched from inception to March 2018 to identify relevant studies on CSU. Data were analyzed with use of the Cochrane Collaboration's Review Manager 5. Read More

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http://dx.doi.org/10.3892/etm.2019.7266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425266PMC
April 2019
1 Read

[Chronic superficial urticaria associated with solid cancers: Case report and literature review].

Ann Dermatol Venereol 2019 Mar 21. Epub 2019 Mar 21.

Service de médecine interne et maladies vasculaires, CHU, 49000 Angers, France. Electronic address:

Background: Chronic urticaria is common and is generally idiopathic ("spontaneous"). Links between solid cancer and chronic urticaria have been mentioned in the literature.

Patients And Methods: We report the case of a 63-year-old man presenting with superficial chronic urticaria associated with adenocarcinoma of the ethmoid sinus. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01519638193005
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http://dx.doi.org/10.1016/j.annder.2019.01.016DOI Listing
March 2019
7 Reads

Cellular and Humoral Responses to Cte f 2, a Cat Flea Allergen, in Children with Papular Urticaria.

Int Arch Allergy Immunol 2019 Mar 22:1-13. Epub 2019 Mar 22.

Allergy Section, Fundación Santa Fe de Bogotá, Faculty of Medicine, Universidad de los Andes, Bogotá, Colombia,

Background: Papular urticaria (PU) is a common insect bite skin hypersensitivity in tropical countries. In order to gain insight into its causal allergens, we aimed to evaluate cellular and humoral immune responses to the recombinant salivary antigen Cte f 2 from the cat flea Ctenocephalides felis.

Method: Sixty patients with PU and 27 healthy controls were included in this study. Read More

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http://dx.doi.org/10.1159/000496743DOI Listing
March 2019
3 Reads

Sexual intercourse as a trigger of inducible urticaria.

Authors:
Mario Geller

Ann Allergy Asthma Immunol 2019 Mar 20. Epub 2019 Mar 20.

Geller Allergy and Immunology Clinic, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2019.03.012DOI Listing
March 2019
2 Reads

Predictive factors for progression to chronicity or recurrence after the first attack of acute urticaria in preschool-age children.

Allergol Immunopathol (Madr) 2019 Mar 20. Epub 2019 Mar 20.

Introduction And Objectives: Preschool-aged group is frequently affected by urticaria, and infections are the most frequently documented factors that cause acute urticaria in children. This prospective study was designed to investigate the underlying factors of acute urticaria in under five-year-old children and to describe predictive factors for progression to chronicity or recurrence after the first attack.

Patients And Methods: Children younger than five years of age with acute urticaria were recruited between July 2015 and July 2016. Read More

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http://dx.doi.org/10.1016/j.aller.2018.12.010DOI Listing
March 2019
3 Reads

Rare presentation of anaphylaxis: pancake syndrome.

BMJ Case Rep 2019 Mar 21;12(3). Epub 2019 Mar 21.

Department of Adult Allergy, Guy's and St Thomas' NHS Foundation Trust, London, UK.

A 43-year-old woman presented with oral discomfort, sneezing, urticaria, eyelid angioedema, abdominal pain, diarrhoea, dyspnoea and wheeze soon after eating a Japanese flour pancake (okonomiyaki, containing wheat, egg, yam, pork, prawn and squid). Subsequent analysis of the flour used in the pancake revealed the presence of (4500 mites/g). The patient tested positive for specific IgE to (15. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22885
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http://dx.doi.org/10.1136/bcr-2018-228854DOI Listing
March 2019
7 Reads

Patient experiences of using Chinese herbal medicine for psoriasis vulgaris and chronic urticaria: A qualitative study.

J Dermatolog Treat 2019 Mar 21:1-28. Epub 2019 Mar 21.

a China-Australia International Research Centre for Chinese Medicine, & School of Health and Biomedical Sciences, RMIT University , PO Box 71, Bundoora Campus , Melbourne , VIC 3083 , Australia.

Background: Psoriasis vulgaris and chronic urticaria are common skin conditions with a significant health burden. Achieving long-term control remains a challenge, and some patients choose Chinese herbal medicine (CHM) to meet this need. Little is known about the motivators and experiences of using CHM for these skin conditions. Read More

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http://dx.doi.org/10.1080/09546634.2019.1591580DOI Listing
March 2019
1 Read

Chronic Urticaria in the Real-Life Clinical Practice Setting in Portugal: Baseline Results from the Non-Interventional Multicentre AWARE Study.

Acta Med Port 2019 Feb 28;32(2):133-140. Epub 2019 Feb 28.

Novartis Farma - Produtos Farmacêuticos, S.A. Porto Salvo. Portugal.

Introduction: There is a paucity of information regarding chronic urticaria patients' care in a real-world setting. The objective of this study was to report and evaluate the baseline characteristics of Portuguese chronic urticaria patients refractory to H1-antihistamines included in the AWARE study.

Material And Methods: This is a non-interventional cohort study. Read More

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http://dx.doi.org/10.20344/amp.9496DOI Listing
February 2019
3 Reads

Allergy to food additives.

Curr Opin Allergy Clin Immunol 2019 Mar 15. Epub 2019 Mar 15.

Division of Allergy, University Department of Pediatrics, Pediatric Hospital Bambino Gesù, Rome, Vatican City, Italy.

Purpose Of Review: To provide an update of the studies concerning the diagnosis and management of food additives allergy.

Recent Findings: Additives improve specific characteristics of food products, but they may induce allergic even life-threatening reactions. Physical examination and medical history are basic to assess specific in-vivo and in-vitro tests. Read More

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http://dx.doi.org/10.1097/ACI.0000000000000528DOI Listing
March 2019
1 Read

Safety profile of iron polymaltose infusions.

Hosp Pract (1995) 2019 Apr 18;47(2):96-98. Epub 2019 Mar 18.

d Department of Pharmacy , Western Hospital , Melbourne , Australia.

Objectives: Iron polymaltose infusions are one type of iron infusate used to treat iron deficiency used in countries such as Australia. We looked at the safety profile of this infusion at one metropolitan hospital in Melbourne, Australia and the associated demographics of those who had reactions.

Methods: A retrospective review of the medical records all adult patients who had an iron polymaltose infusion at Western Hospital over 12 months was performed. Read More

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http://dx.doi.org/10.1080/21548331.2019.1593006DOI Listing
April 2019
4 Reads

infection as a reversible cause of chronic urticaria.

J Asthma Allergy 2019 26;12:67-69. Epub 2019 Feb 26.

Department of Allergy, Immunology and Respiratory Medicine, Alfred Health, Melbourne, VIC, Australia,

Recurrent urticaria is a frequent presenting complaint in the Allergy Clinic, despite the fact that chronic urticaria is not an IgE-mediated (atopic) condition in most cases. We present four cases assessed over 5 years in our allergy service who were found to have evidence of strongyloidiasis and whose clinical features resolved with standard anti-helminth treatment. Read More

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http://dx.doi.org/10.2147/JAA.S167292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396652PMC
February 2019
1 Read

A Sea Change in the Treatment of Chronic Urticaria.

Actas Dermosifiliogr 2019 Mar 14. Epub 2019 Mar 14.

Servicio de Dermatología, Hospital del Mar, Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Universitat Autònoma de Barcelona, Barcelona, España. Electronic address:

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http://dx.doi.org/10.1016/j.ad.2018.11.003DOI Listing
March 2019
1 Read

Effects of an Oral CRTh2 Antagonist (AZD1981) on Eosinophil Activity and Symptoms in Chronic Spontaneous Urticaria.

Int Arch Allergy Immunol 2019 Mar 15:1-10. Epub 2019 Mar 15.

Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Background: Approximately 50% of patients with chronic spontaneous urticaria (CSU) experience symptoms that are not fully controlled by antihistamines, indicating an unmet clinical need.

Objective: To evaluate the effects of the selective CRTh2 antagonist AZD1981 on symptoms and targeted leukocytes in adults with persistent CSU despite treatment with H1-antihistamines.

Methods: We performed a single-center, randomized, placebo-controlled study involving adult CSU subjects with symptoms despite daily antihistamines. Read More

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http://dx.doi.org/10.1159/000496162DOI Listing
March 2019
1 Read

Common Annular Lesions in the Pediatric Population: Part 2.

Pediatr Ann 2019 Mar;48(3):e135-e138

Rash is a common chief complaint for patients presenting to their physician, especially within the pediatric field. The ability to distinguish characteristics of a rash, including morphology, distribution, and configuration, is critical to forming the differential diagnosis. This is the second article of a 2-part review that discusses the common rashes that present in an annular configuration. Read More

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http://dx.doi.org/10.3928/19382359-20190222-01DOI Listing
March 2019
3 Reads

Effective treatment of different H1-antihistamine-refractory chronic urticaria phenotypes with omalizumab.

Turk Pediatri Ars 2018 Dec 1;53(4):250-254. Epub 2018 Dec 1.

Department of Pediatrics, Division of Pediatric Allergy and Immunology, Adnan Menderes University School of Medicine, Aydın, Turkey.

Omalizumab is a recombinant humanized monoclonal anti-IgE antibody. Until now, the efficiency of omalizumab in chronic spontaneous urticaria has been demonstrated in several studies. However in the literature, data showing the efficiency of omalizumab in different phenotypes of H1-antihistamine-refractory chronic urticaria are limited. Read More

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http://dx.doi.org/10.5152/TurkPediatriArs.2016.4042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408194PMC
December 2018
1 Read