585 results match your criteria Urothelial Tumors of the Renal Pelvis and Ureters


Renal metastases from esophageal cancer and retroperitoneal lymphoma detected via chromosome duplications identified by fluorescence in situ hybridization in urine exfoliated cells: First 2 case reports.

Medicine (Baltimore) 2021 Mar;100(10):e24010

Department of Urology, Tongji Hospital Affiliated Tongji Medical College of Huazhong University of Science and Technology (HUST), 1095 Jiefang Avenue, Wuhan, China.

Rationale: Renal-occupying lesions positive for urine fluorescence in situ hybridization (FISH) are usually considered urothelial carcinomas. Here, we describe 2 cases of renal metastases with chromosome duplications in urine exfoliated cells.

Patient Symptoms: Patient 1, a 56-year-old male with a history of esophageal cancer, was admitted to our hospital on May 2017 after presenting with right back pain with microscopic hematuria for 1 month. Read More

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Large distal ureteric stone with high burden urothelial cancer of the entire ureter and renal pelvis: a dual pathology.

Ann R Coll Surg Engl 2021 Apr 5;103(4):e136-e139. Epub 2021 Mar 5.

Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Upper-tract urothelial cancer comprises only 3% of all urothelial cancers. Risk factors include tobacco smoking, recurrent urinary infection, urolithiasis and analgesic abuse. Urolithiasis-induced chronic inflammation leads to urothelial proliferation and eventual malignant transformation. Read More

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Genetic Differences Between Bladder and Upper Urinary Tract Carcinoma: Implications for Therapy.

Eur Urol Oncol 2021 Apr 30;4(2):170-179. Epub 2020 Dec 30.

Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, CA, USA.

Context: Bladder urothelial carcinoma (BUC) and upper tract urothelial carcinoma (UTUC) have genetic differences, which may influence therapy.

Objective: The aim of the current review was to summarize the current genetic understanding of upper tract and BUC.

Evidence Acquisition: PubMed, Cochrane, and Web of Science online databases were searched systematically up to February 2020, using the following keywords: urothelial carcinomas, upper urinary tract, renal pelvis, ureter, bladder cancer, and genetics. Read More

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Upper Urinary Tract Tumors: Variant Histology Versus Urothelial Carcinoma.

Clin Genitourin Cancer 2020 Dec 2. Epub 2020 Dec 2.

Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, Québec, Canada.

Purpose: To evaluate stage at presentation and cancer-specific mortality (CSM) in upper urinary tract tumors according to histologic subtype.

Methods: Within the Surveillance, Epidemiology, and End Results registry (SEER, 2004-2016), we identified patients with upper urinary tract tumors with pure variant histology (UTVH) and pure upper urinary tract urothelial carcinoma (UTUC). Cumulative incidence plots, after propensity score matching for tumor and patient characteristics, addressed CSM. Read More

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December 2020

The cytologic and histologic diagnosis of ureteral fibroepithelial polyp in a dog.

Vet Clin Pathol 2020 Dec 17;49(4):646-651. Epub 2020 Dec 17.

Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA.

A 6-year-old, intact male, brindled, 30-Lb English Bulldog presented to the Purdue University Veterinary Teaching Hospital with a recurrent history of hematuria, periuria, and lethargy that responded temporarily to antibiotic therapy. The work-up included a complete blood count, serum biochemical profile, complete urinalysis, diagnostic imaging (abdominal radiographs and ultrasound with contrast urography), and exploratory laparotomy. The diagnostic imaging findings and subsequent exploratory revealed a unilateral, intraluminal, right-sided, 3-cm ureteral mass extending from the proximal ureter into the renal pelvis. Read More

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December 2020

Complete retroperitoneal laparoscopic nephroureterectomy with bladder cuff excision for upper tract urothelial carcinoma without patient repositioning: a single-center experience.

J Int Med Res 2020 Nov;48(11):300060520973915

Department of Urology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China.

Objective: This study was performed to evaluate the outcome of complete retroperitoneal laparoscopic nephroureterectomy with bladder cuff excision (RLNU-BCE), which is performed to treat urothelial carcinomas in the renal pelvis or in the ureter higher than the crossing of the common iliac artery without patient repositioning.

Methods: We retrospectively analyzed the clinical data of 48 patients with upper tract urothelial carcinoma who underwent complete RLNU-BCE in our institution from May 2017 to September 2019.

Results: RLNU-BCE was successfully performed in all 48 patients. Read More

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November 2020

Stage Migration for Upper Tract Urothelial Cell Carcinoma.

Clin Genitourin Cancer 2020 Oct 13. Epub 2020 Oct 13.

Division of Urology, Department of Surgery, Saint Louis University, St Louis, MO. Electronic address:

Introduction: Upper tract urothelial carcinomas (UTUCs) account for 5% to 10% of urothelial cancers. The phenomenon of stage migration in tumors has been evident with increased use and higher resolution of cross-sectional imaging. Using the National Cancer Database, we analyzed trends in stage at presentation and overall survival for UTUCs. Read More

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October 2020

Clinical Impact of Tumor-Infiltrating Lymphocytes and PD-L1-Positive Cells as Prognostic and Predictive Biomarkers in Urological Malignancies and Retroperitoneal Sarcoma.

Cancers (Basel) 2020 Oct 27;12(11). Epub 2020 Oct 27.

Department of Urology, Nara Medical University, Nara 634-8522, Japan.

Over the past decade, an "immunotherapy tsunami", more specifically that involving immune checkpoint inhibitors (ICIs), has overtaken the oncological field. The interaction and cross-talk among tumor cells and several immune cells in the tumor microenvironment are dynamic and complex processes. As immune contexture can vary widely across different types of primary tumors and tumor microenvironments, there is still a significant lack of clinically available definitive biomarkers to predict patient response to ICIs, especially in urogenital malignancies. Read More

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October 2020

The influence of post-diuretic late phase imaging in visual and quantitative evaluation of urothelial tumors by F-18 fluorodeoxyglucose positron emission tomography/computed tomography.

Turk J Urol 2019 Dec 1;45(Supp. 1):S56-S62. Epub 2019 Dec 1.

Department of Oncology, Mersin University School of Medicine, Mersin, Turkey.

Objective: Although F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is a valuable imaging method in most of the malignant tumors, it is considered to have limited diagnostic ability in urothelial tumors due to high physiologic urine activity. The aim of the present study was to evaluate the effect of post-diuretic late phase imaging to the visual and quantitative evaluation of urothelial tumors in the staging and restaging of the patients.

Material And Methods: Two patients with ureter and 40 patients with bladder tumors (6 females and 36 males, mean age: 67. Read More

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December 2019

High-grade urothelial carcinoma in urine cytology: different spaces - different faces, highlighting morphologic variance.

J Am Soc Cytopathol 2021 Jan-Feb;10(1):36-40. Epub 2020 Aug 7.

New York-Presbyterian Hospital/Weill Cornell Medicine, Department of Pathology and Laboratory Medicine, New York, New York.

Introduction: The Paris System for Reporting Urinary Cytology (TPS) was first published in 2016 to standardize reporting and placed a specific emphasis on high-grade urothelial carcinoma (HGUC). The urinary tract is anatomically divided into the upper tract (UT) and the lower tract (LT). A major morphologic criterion in TPS for HGUC defines the nuclear-to-cytoplasmic (N/C) ratio as ≥ 0. Read More

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Nephroureterectomy vs. segmental ureterectomy of clinically localized, high-grade, urothelial carcinoma of the ureter: Practice patterns and outcomes.

Urol Oncol 2020 11 26;38(11):851.e1-851.e10. Epub 2020 Aug 26.

Main Line Health, Department of Urology, Wynnewood, PA.

Background: Nephroureterectomy (NU) remains the gold-standard for upper-tract urothelial carcinoma (UTUC). However, nephron-sparing management (NSM), specifically segmental ureterectomy (SU) for urothelial tumors distal to the renal pelvis may offer decreased risk of renal insufficiency and equivalent cancer control.

Objectives: To identify patient-specific and facility-related factors that are associated with the selection of SU vs. Read More

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November 2020

Ureteral location is associated with survival outcomes in upper tract urothelial carcinoma: A population-based analysis.

Int J Urol 2020 Nov 9;27(11):966-972. Epub 2020 Aug 9.

Division of Urology, Department of Surgery, VCU Health System, Richmond, Virginia, USA.

Objectives: To evaluate the prognostic value of tumor location in patients with upper tract urothelial carcinoma.

Methods: Within the Surveillance, Epidemiology and End Results Incidence Database, 6619 upper tract urothelial carcinoma cases were identified, including 3719 confined to the renal pelvis and 2971 to the ureter. Predictors of surgical technique (kidney sparing surgery versus radical nephroureterectomy), as well as 2- and 5-year cancer-specific survival and overall survival were evaluated. Read More

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November 2020

Endoscopy: Minimal-Invasive Treatment Approach of Bilateral Upper Tract Urothelial Carcinoma Associated with Lynch Syndrome-A Case Report.

J Endourol Case Rep 2019 30;5(3):110-112. Epub 2019 Aug 30.

Department of Urology, Medical University of Innsbruck, Innsbruck, Austria.

Upper tract urothelial carcinomas (UTUCs) are infrequent neoplasms occurring in the pelvis renalis or the ureter with an incidence between 5% and 10% of all urothelial carcinomas. In addition, a synchronous bilateral appearance is extremely rare with a quantity of only 1.6% of all UTUCs. Read More

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Long-term ureteroscopic management of upper tract urothelial carcinoma: 28-year single-centre experience.

Jpn J Clin Oncol 2021 Jan;51(1):130-137

Innovation Center Okayama for Nanobio-Targeted Therapy, Okayama University, 2-5-1, Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.

Background: Long-term survival outcomes of patients who undergo endoscopic management of non-invasive upper tract urothelial carcinoma remain uncertain. The longest mean follow-up period in previous studies was 6.1 years. Read More

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January 2021

[Lipid cell variant urothelial carcinoma of the renal pelvis. A case report and literature review].

Rev Esp Patol 2020 Jul - Sep;53(3):197-199. Epub 2019 Apr 5.

Sección de Patología, Fundació Puigvert, Universitat Autónoma de Barcelona, Barcelona, España.

There are many variants of urothelial carcinoma. One of the most infrequent is formed by cells with a lipid content and an adipose tissue appearance. Only 43 cases have been reported in the bladder, 2 in the renal pelvis and 1 case in the ureter. Read More

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European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2020 Update.

Eur Urol 2021 01 24;79(1):62-79. Epub 2020 Jun 24.

Department of Urology, Hospital Motol, Second Faculty of Medicine, Charles University, Prague, Czech Republic; Department of Urology Comprehensive Cancer Centre, Medical University of Vienna, Vienna, Austria; Department of Urology, Weill Cornell Medical College, New York, NY, USA; Department of Urology, University of Texas Southwestern, Dallas, TX, USA; Institute for Urology and Reproductive Health, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.

Context: The European Association of Urology (EAU) Guidelines Panel on Upper Urinary Tract Urothelial Carcinoma (UTUC) has prepared updated guidelines to aid clinicians in the current evidence-based management of UTUC and to incorporate recommendations into clinical practice.

Objective: To provide an overview of the EAU guidelines on UTUC as an aid to clinicians.

Evidence Acquisition: The recommendations provided in the current guidelines are based on a thorough review of available UTUC guidelines and articles identified following a systematic search of Medline. Read More

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January 2021

The effectiveness of chemotherapy for patients with pT3N0M0 renal pelvic urothelial carcinomas: An inverse probability of treatment weighting comparison using Surveillance, Epidemiology, and End Results data.

Cancer Med 2020 08 25;9(16):5756-5766. Epub 2020 Jun 25.

Department of Urology, Cancer Center, Sun Yat-sen University, Guangzhou, China.

Introduction: Unlike the established evidence to use chemotherapy for urothelial carcinoma of the bladder, presently there are insufficient data to inform a recommendation on upper urinary tract urothelial carcinoma treatment. The prognosis for patients with stage T4 and positive lymph nodes is poor; however, primary tumors in the renal pelvis are associated with favorable prognoses compared to those located in the ureter. Our study aimed at investigating the effectiveness of chemotherapy in patients with pT3N0M0 renal pelvic urothelial carcinomas (RPUC) who have relative favorable prognosis. Read More

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A prognostic nomogram for the cancer-specific survival of patients with upper-tract urothelial carcinoma based on the Surveillance, Epidemiology, and End Results Database.

BMC Cancer 2020 Jun 8;20(1):534. Epub 2020 Jun 8.

Department of Clinical Research, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.

Background: The aim of this study was to establish a comprehensive nomogram for the cancer-specific survival (CSS) of patients with upper-tract urothelial carcinoma (UTUC) and compare it with the traditional American Joint Committee on Cancer (AJCC) staging system in order to determine its reliability.

Methods: This study analyzed 9505 patients with UTUC in the Surveillance, Epidemiology, and End Results (SEER) database. R software was used to randomly divided the patients in a 7-to-3 ratio to form a training cohort (n = 6653) and a validation cohort (n = 2852). Read More

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Pattern and risk factors of local recurrence after nephroureterectomy for upper tract urothelial carcinoma.

World J Surg Oncol 2020 May 30;18(1):114. Epub 2020 May 30.

Department of Radiation Oncology, Rush University Medical Center , Chicago, USA.

Purpose: This study aims to identify predictive local recurrence risk factors and site-specific local recurrence pattern of upper tract urothelial carcinoma (UTUC) with different primary tumor locations.

Methods: Three hundred and eighty-nine UTUC patients with radical nephroureterectomy were included in this study. Univariate and multivariate Cox proportional hazards regressions were performed to measure the risk of local recurrence. Read More

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Initial experience of complete laparoscopic radical nephroureterectomy combined with transvesical laparoscopic excision of distal ureter in patients with upper urinary tract cancer.

World J Surg Oncol 2020 May 25;18(1):104. Epub 2020 May 25.

Department of Urology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.

Background: Selecting the treatment procedure for cancer patients is a challenging task. We report our initial experience of complete laparoscopic radical nephroureterectomy (RNU) for patients with upper urinary tract urothelial cancer (UTUC).

Methods: A total of four patients with UTUC underwent complete laparoscopic RNU combined with transvesical laparoscopic excision of the distal ureter using three 5-mm ports. Read More

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Text mining in a literature review of urothelial cancer using topic model.

BMC Cancer 2020 May 24;20(1):462. Epub 2020 May 24.

Division of Nephrology, Asia University Hospital, Taichung, Taiwan.

Background: Urothelial cancer (UC) includes carcinomas of the bladder, ureters, and renal pelvis. New treatments and biomarkers of UC emerged in this decade. To identify the key information in a vast amount of literature can be challenging. Read More

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Characteristics of bladder recurrence after radical nephroureterectomy in upper urinary tract cancer

Orv Hetil 2020 05;161(21):881-888

Általános Orvostudományi Kar, Urológiai Klinika,Semmelweis Egyetem Budapest, Üllői út 26., 1085.

Introduction: Urothelial cancer can develop in the renal pelvis, ureters, bladder and the proximal urethra as urothelial tissue can be found in these organs. Upper tract urothelial carcinoma is rare but better understanding of the natural history of the disease is important because bladder recurrence often occurs after radical nephroureterectomy.

Aim And Method: Our retrospective study aims to describe the general characteristics of patients treated with radical nephroureterectomy at the Department of Urology, Semmelweis University, between January 1st, 2005 and December 31st, 2016. Read More

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Inverted urothelial papilloma of the upper urinary tract: description of two cases with systematic literature review.

Diagn Pathol 2020 Apr 22;15(1):40. Epub 2020 Apr 22.

Pathology Section, Department of Health Sciences, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy.

Background: Inverted urothelial papilloma (IUP) of the upper urinary tract is an uncommon benign tumour that occasionally presents as a polypoid mass causing urinary obstruction. Histologically, IUP is characterised by a proliferating urothelium arranged in cords and trabeculae, in continuity with overlying intact epithelium, and extending into the lamina propria in a non-invasive, endophytic manner. Cytological atypia is minimal or absent. Read More

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Development and external validation of a preoperative nomogram for predicting pathological locally advanced disease of clinically localized upper urinary tract carcinoma.

Cancer Med 2020 06 6;9(11):3733-3741. Epub 2020 Apr 6.

Department of Urology and Andrology, Kansai Medical University, Osaka, Japan.

Objective: To develop and validate a preoperative nomogram to predict pathological locally advanced disease (pLAD) of clinically localized upper urinary tract urothelial carcinoma (UTUC) treated with extirpative surgery.

Methods: In total, 1101 patients with cN0M0 UTUC (development cohort, n = 604; validation cohort, n = 497) from 2 independent academic databases were retrospectively analyzed. pLAD was defined as pT3/4 and/or pN+. Read More

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High prevalence of airway obstruction and pulmonary emphysema in urothelial (renal pelvis, ureter, and bladder) cancer patients.

Respir Investig 2020 Jul 20;58(4):239-245. Epub 2020 Feb 20.

Department of Respiratory Medicine, Ijinkai Takeda General Hospital, 28-1, Ishida Moriminami-cho, Fushimi-ku, Kyoto-city, Kyoto, Japan. Electronic address:

Background: Cigarette smoking is a major cause of COPD, with patients also presenting complications that stem from other smoking-related diseases, including urothelial cancer. However, the prevalence of COPD or airflow obstruction in urothelial cancer patients has not been well studied.

Methods: We investigated the prevalence of airflow obstruction (FEV1/FVC < 70%) in newly diagnosed urothelial cancer patients and identified the risk factors for airflow obstruction in existing urothelial cancer patients. Read More

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HER2 Status in Molecular Subtypes of Urothelial Carcinoma of the Renal Pelvis and Ureter.

Clin Genitourin Cancer 2020 08 13;18(4):e443-e449. Epub 2019 Dec 13.

Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan. Electronic address:

Introduction: Erb-b2 receptor tyrosine kinase 2 (ERBB2, also known as HER2) gene amplification or protein overexpression occurs in certain types of urothelial carcinomas. Molecular pathologic classification of urinary bladder cancer using immunohistochemistry has identified basal and luminal subtypes with differing prognoses, but the HER2 status of these subtypes has not been investigated. In addition, research on urothelial carcinoma of the renal pelvis and ureter (UCRPU) has not progressed because of its rarity, though its prognosis is worse than that of bladder cancer. Read More

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Clinicopathologic analysis of upper urinary tract carcinoma with variant histology.

Virchows Arch 2020 Jul 16;477(1):111-120. Epub 2020 Jan 16.

Department of Surgery and Pathology, Faculty of Medicine, Cordoba University, Cordoba, Spain.

We report on the clinicopathologic features of 115 cases of high-grade urothelial carcinoma of the upper urinary tract with variant histology present in 39 (34%). Variant histology was typically seen in high pathological stage (pT2-pT4) (82%, 32 cases) patients with lower survival rate (70%, 27 cases, median survival 31 months) and consisted in urothelial with one (23%), two (3%), and three or more variants (3%); 4% of cases presented with pure variant histology. Squamous divergent differentiation was the most common variant (7%) followed by sarcomatoid (6%) and glandular (4%), followed by 3% each of micropapillary, diffuse-plasmacytoid, inverted growth, clear cell glycogenic, or lipid-rich. Read More

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Urothelial Carcinoma of the Renal Pelvis and Ureter: Does Location Make a Difference?

Clin Genitourin Cancer 2020 02 6;18(1):45-49.e1. Epub 2019 Nov 6.

Department of Urology, University of Arizona, Tucson, AZ. Electronic address:

Background: There is a paucity of data on outcomes of upper tract urothelial carcinoma (UTUC) arising from the renal pelvis (RPUC) versus UTUC arising from the ureter (UUC). The published literature is conflicting, and there is no consensus on patient prognosis based on disease location. The aim of this study is to compare clinical and survival outcomes based on location of primary tumor using a large national registry. Read More

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February 2020

Renal Pelvis Urothelial Carcinoma With Bowel Metastases.

Clin Nucl Med 2019 Dec;44(12):983-984

Oncology, Penang Adventist Hospital, George Town, Penang, Malaysia.

Urothelial carcinoma is the fourth most common genitourinary tumor with the majority of the tumor involving the urinary bladder. Only 5% involves the renal pelvis and ureter. Metastatic urothelial carcinoma of the renal pelvis frequently involves the lymph nodes, lung, liver, bone, and peritoneum. Read More

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December 2019