528 results match your criteria Urothelial Tumors of the Renal Pelvis and Ureters


Multifocal Synchronous Upper Urinary Tract Carcinosarcoma (Sarcomatoid Carcinoma) With Rhabdomyoblastic Differentiation.

Int J Surg Pathol 2019 Feb 15:1066896919828111. Epub 2019 Feb 15.

1 Department of Urology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.

Carcinosarcoma of the upper urinary tract is very rare. In this article, we report a case of upper urinary tract carcinosarcoma with rhabdomyoblastic differentiation showing distinct transition between the epithelial and mesenchymal components confirmed by morphology and immunohistochemistry. An 81-year-old female underwent radical nephroureterectomy under the diagnosis of left ureteral urothelial carcinoma (UC). Read More

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http://dx.doi.org/10.1177/1066896919828111DOI Listing
February 2019
1 Read

Contemporary best practice in the management of urothelial carcinomas of the renal pelvis and ureter.

Ther Adv Urol 2019 Jan-Dec;11:1756287218815372. Epub 2019 Jan 8.

Section of Pathological Anatomy, Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Via Conca 71, Ancona, Marche, I-60126, Italy.

Upper tract urothelial carcinoma (UTUC) accounts for 5% of urothelial carcinomas (UCs), the estimated annual incidence being 1-2 cases per 100,000 inhabitants. Similarly to bladder UC, divergent differentiations and histologic variants confer an adverse risk factor in comparison with pure UTUC. Molecular and genomic characterization studies on UTUC have shown changes occurring at differing frequencies from bladder cancer, with unique molecular and clinical subtypes, potentially with different responses to treatment. Read More

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http://dx.doi.org/10.1177/1756287218815372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329040PMC
January 2019
8 Reads

[Value of imaging in upper urinary tract tumors].

Urologe A 2019 Jan;58(1):5-13

Klinik und Poliklinik für Radiologie, Klinikum der Universität München, Campus Großhadern, München, Deutschland.

Background: Staging of bladder cancer, hematuria as well as the evaluation of unclear findings of the kidneys and ureters are the most frequent indications for imaging of the upper urinary tract (UUT). Endourological assessment of the UUT is much more invasive compared to imaging of the bladder, raising the question of the optimal imaging technique. Several technical improvements regarding computed tomography (CT) as well as magnetic resonance imaging (MRI) were implemented in recent years. Read More

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http://dx.doi.org/10.1007/s00120-018-0828-7DOI Listing
January 2019
1 Read

High Serum CA19-9 Concentration Indicates High Chemosensitivity and Better Survival in Advanced Urothelial Carcinoma.

Anticancer Res 2019 Jan;39(1):375-380

Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.

Background: The present study was conducted to investigate whether baseline serum carbohydrate antigen (CA) 19-9 predicts prognosis or treatment effect in patients with advanced urothelial carcinoma (UC).

Materials And Methods: We retrospectively analyzed data of patients diagnosed with locally advanced or metastatic or recurrent UC between April 2008 and November 2014. CA19-9 was determined using enzyme-linked immunosorbent assay (ELISA) and the relationship between CA19-9 and prognosis were analyzed. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13122DOI Listing
January 2019
9 Reads

Preoperative multiplex nomogram for prediction of high-risk nonorgan-confined upper-tract urothelial carcinoma.

Urol Oncol 2018 Dec 22. Epub 2018 Dec 22.

Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

Background: Accurate risk stratification prior to radical nephroureterectomy remains a challenge with upper-tract urothelial carcinoma (UTUC). Herein, we generated an optimized preoperative tool predicting high-risk nonorgan-confined (NOC)-UTUC.

Materials And Methods: Retrospective evaluation of 699 patients undergoing radical nephroureterectomy at 3 academic centers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10781439183049
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http://dx.doi.org/10.1016/j.urolonc.2018.12.002DOI Listing
December 2018
2 Reads

Rates of lymph node invasion and their impact on cancer specific mortality in upper urinary tract urothelial carcinoma.

Eur J Surg Oncol 2018 Dec 11. Epub 2018 Dec 11.

Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada; Centre de recherche du Centre Hospitalier de l'Université de Montréal (CR-CHUM) and Institut du cancer de Montréal, Montréal, Québec, Canada.

Purpose: To analyze lymph node invasion (LNI) rates according to tumor characteristics and to test the impact of LNI and its extent on cancer specific mortality (CSM) in surgically-treated non metastatic urothelial upper urinary tract carcinoma (UTUC) patients.

Materials And Methods: Within the SEER database (2004-2014), we identified 2098 patients with histologically confirmed non-metastatic urothelial carcinoma of renal pelvis or ureter who underwent NU with LND. LNI rates stratified according to tumor location and stage were described. Read More

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http://dx.doi.org/10.1016/j.ejso.2018.12.004DOI Listing
December 2018
1 Read

Tumors of Renal Collecting Systems, Renal Pelvis, and Ureters: Role of MR Imaging and MR Urography Versus Computed Tomography Urography.

Magn Reson Imaging Clin N Am 2019 Feb;27(1):15-32

Abdominal Imaging Division, UT Southwestern University Hospitals, 5323 Harry Hines Boulevard, Dallas, TX 75390-8827, USA.

Hematuria evaluation remains a common problem, particularly in patients who smoke and are at risk for urothelial tumors. Lifetime surveillance of the urothelium is often required once urothelial cancer is diagnosed. Computed tomography urography (CTU) has exquisite sensitivity and specificity for identification of renal and urothelial lesions. Read More

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http://dx.doi.org/10.1016/j.mric.2018.09.002DOI Listing
February 2019
8 Reads

Recent advances in upper tract urothelial carcinomas: From bench to clinics.

Int J Urol 2019 02 29;26(2):148-159. Epub 2018 Oct 29.

Division of Urology, Department of Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Urothelial carcinoma in the upper tract is rare and often discussed separately. Many established risk factors were identified for the disease, including genetic and external risk factors. Radiographic survey, endoscopic examination and urine cytology remained the most important diagnostic modalities. Read More

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http://doi.wiley.com/10.1111/iju.13826
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http://dx.doi.org/10.1111/iju.13826DOI Listing
February 2019
7 Reads

[French ccAFU guidelines - Update 2018-2020: Upper tract urothelial carcinoma].

Prog Urol 2018 Nov 11;28(12S):S32-S45. Epub 2018 Oct 11.

Comité de cancérologie de l'Association française d'urologie, groupe vessie, Maison de l'Urologie, 11, rue Viète, 75017 Paris, France; Service d'urologie, hôpital Européen-Georges-Pompidou, université Paris Descartes, AP-HP, 75015 Paris, France.

Introduction: To propose an update of the French guidelines from the national committee ccAFU on upper tract urothelial carcinomas (UTUC).

Methods: A systematic Medline search was performed between 2016 and 2018, with regards to the diagnosis, the options of treatment and the follow-up of UTUC, to evaluate the different studies with levels of evidence.

Results: The diagnosis of this rare disease is based on CT-scan acquisition during excretion and ureteroscopy with histological biopsies. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S11667087183046
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http://dx.doi.org/10.1016/j.purol.2018.07.284DOI Listing
November 2018
11 Reads

Evaluation of upper tract urothelial carcinomas by contrast-enhanced ultrasound.

Radiologia 2018 Nov - Dec;60(6):496-503. Epub 2018 Sep 25.

Servicio de Radiodiagnóstico, Hospital Universitario Doctor Peset, Valencia, España.

Aim: To describe the findings and behaviour of contrast-enhanced ultrasound in the study of upper tract urothelial tumours and to assess its usefulness for diagnosis.

Material And Methods: We reviewed our hospital's database over a period of 45 months to identify patients diagnosed with upper tract urothelial carcinomas. We reviewed the findings on mode B-ultrasound, contrast-enhanced ultrasound (location and qualitative assessment of intensity and washout of enhancement), and made a comparison with other techniques (computed tomography or magnetic resonance), and with the surgical specimen. Read More

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http://dx.doi.org/10.1016/j.rx.2018.07.005DOI Listing
September 2018
10 Reads

Fibroblast growth factor receptor 3 (FGFR3) aberrations in muscle-invasive urothelial carcinoma.

BMC Urol 2018 Jul 31;18(1):68. Epub 2018 Jul 31.

Division of Hematology-Oncology, Department of Medicine, Sungkyunkwan University Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.

Background: Recent studies suggest that FGFR3 is a potential therapeutic target in urothelial carcinoma (UC). The purpose of this study was to evaluate the rates and types of FGFR3 aberrations in patients with muscle-invasive UC who received radical resection.

Methods: We analyzed surgical tumor samples from 74 UC patients who had received radical cystectomy (n = 40) or ureteronephrectomy (n = 34). Read More

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http://dx.doi.org/10.1186/s12894-018-0380-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069868PMC
July 2018
1 Read

Risk Factors for Bladder Cancer Recurrence Survival in Patients with Upper-Tract Urothelial Carcinoma.

Tumori 2017 Dec 1:tj5000705. Epub 2017 Dec 1.

Departments of Urology, First Affiliated Hospital of Fujian Medical University, Fuzhou - PR China.

Purpose The aim of this work was to investigate the predictive factors for bladder cancer recurrence survival (BCRS) in patients with upper-tract urothelial carcinoma (UTUC). Methods We selected patients with UTUC who underwent segmental ureterectomy (Su) or nephroureterectomy (Nu) from 2004 to 2013 from the Surveillance, Epidemiology, and End Results (SEER) database. Patients with a history of intravesical therapy for bladder cancer and bladder cancer prior to the diagnosis of UTUC were excluded. Read More

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http://dx.doi.org/10.5301/tj.5000705DOI Listing
December 2017
14 Reads

Coincidental Bladder Cuff Transitional Cell Carcinoma in Nephroureterectomy Specimens: Risk Factors, Prognosis and Clinical Implementation.

Urol J 2018 Sep 26;15(5):256-260. Epub 2018 Sep 26.

Mafraq Hospital, United Arab Emirates.

Purpose: There is a lack of reporting of the bladder cuff pathology in the literature and ongoing debate regarding the role of bladder cuff excision (BCE) in the prognosis in patients with upper tract urothelial carcinoma (UTUC). We aimed to know the risk factors, the survival, and the clinical course of such pathology.

Materials And Methods: The study was retrospective, from 1983-2013 on 305 patients who had diagnosed with UTUC. Read More

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http://dx.doi.org/10.22037/uj.v0i0.4069DOI Listing
September 2018
10 Reads

Comparison of clinicopathologic characteristics, epigenetic biomarkers and prognosis between renal pelvic and ureteral tumors in upper tract urothelial carcinoma.

BMC Urol 2018 Mar 27;18(1):22. Epub 2018 Mar 27.

Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Centre, No. 8 Xishiku St, Xicheng District, Beijing, 100034, China.

Background: There's no consensus about the difference between renal pelvic and ureteral tumors in terms of clinical features, pathological outcomes, epigenetic biomarkers and prognosis.

Methods: The data of 341 patients with renal pelvic tumors and 271 patients with ureteral tumors who underwent radical nephroureterectomy between 1999 and 2011 were retrospectively reviewed. The clinicopathologic features, gene promoters methylation status and oncologic outcomes were compared. Read More

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http://dx.doi.org/10.1186/s12894-018-0334-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870733PMC
March 2018
3 Reads

Ki-67 as a Prognostic Marker in Upper Urinary Tract Urothelial Carcinoma: A Systematic Review and Meta-Analysis.

Clin Genitourin Cancer 2018 08 24;16(4):e831-e841. Epub 2018 Feb 24.

Department of Urology, Seoul National University Hospital, Seoul, Korea. Electronic address:

Background: We systematically evaluated the prognostic significance of Ki-67 on survival outcomes in patients with upper urinary tract urothelial carcinoma (UTUC) treated with radical nephroureterectomy (RNU).

Materials And Methods: We searched the Embase, Scopus, and PubMed databases for all articles published up to February 2017 by following the Preferred Reporting Items for Systematic Review and Meta-analyses guidelines. The outcomes of interest included intravesical recurrence (IVR)-free survival, disease-free survival (DFS), cancer-specific survival (CSS), and overall survival (OS). Read More

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http://dx.doi.org/10.1016/j.clgc.2018.02.010DOI Listing
August 2018
5 Reads

study in nephroureterectomy specimens defining the role of 3-D upper urinary tract visualization using optical coherence tomography and endoluminal ultrasound.

J Med Imaging (Bellingham) 2018 Jan 12;5(1):017001. Epub 2018 Feb 12.

University of Amsterdam, Academic Medical Center, Department of Biomedical Engineering and Physics, Amsterdam, The Netherlands.

Minimal invasive endoscopic treatment for upper urinary tract urothelial carcinoma (UUT-UC) is advocated in patients with low-risk disease and limited tumor volume. Diagnostic ureterorenoscopy combined with biopsy is the diagnostic standard. This study aims to evaluate two alternative diagnostic techniques for UUT-UC: optical coherence tomography (OCT) and endoluminal ultrasound (ELUS). Read More

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http://dx.doi.org/10.1117/1.JMI.5.1.017001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808355PMC
January 2018
16 Reads

Comparison of Pathological Stage in Patients Treated with and without Neoadjuvant Chemotherapy for High Risk Upper Tract Urothelial Carcinoma.

J Urol 2018 07 4;200(1):68-73. Epub 2018 Jan 4.

Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland; The Greenberg Bladder Cancer Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland.

Purpose: High risk upper tract urothelial carcinoma has been associated with poor survival outcomes. Limited retrospective data support neoadjuvant chemotherapy prior to radical nephroureterectomy. To validate prior findings we evaluated differences in the pathological stage distribution in patients with high risk upper tract urothelial carcinoma based on the administration of neoadjuvant chemotherapy before radical nephroureterectomy. Read More

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http://dx.doi.org/10.1016/j.juro.2017.12.054DOI Listing
July 2018
3 Reads

Standardized and Simplified Retroperitoneal Lymph Node Dissection During Retroperitoneal Laparoscopic Radical Nephroureterectomy for Urothelial Carcinoma of the Upper Ureter or Renal Pelvis: En Bloc Resection Technique.

Urology 2018 Feb 20;112:85-91. Epub 2017 Nov 20.

Department of Urology, Ijinkai Takeda General Hospital, Kyoto, Japan.

Objective: To describe our en bloc technique of retroperitoneal lymph node dissection (RPLND) during retroperitoneal laparoscopic radical nephroureterectomy for upper urinary tract urothelial carcinoma and evaluate perioperative outcomes.

Methods: From 2002 to 2015, 114 patients with urinary tract urothelial carcinoma located at the pelvis or upper or middle ureter underwent retroperitoneal laparoscopic radical nephroureterectomy at 2 institutions. Performance of RPLND began in February 2009. Read More

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http://dx.doi.org/10.1016/j.urology.2017.11.001DOI Listing
February 2018
17 Reads

Potential Benefit of Lymph Node Dissection During Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: A Systematic Review by the European Association of Urology Guidelines Panel on Non-muscle-invasive Bladder Cancer.

Eur Urol Focus 2017 Nov 17. Epub 2017 Nov 17.

Academic Department of Urology, La Pitié-Salpétrière Hospital, Assistance-Publique Hôpitaux de Paris, Paris, France.

Context: The oncological efficacy of routine lymphadenectomy (lymph node dissection [LND]) at the time of radical nephroureterectomy (RNU) remains controversial.

Objective: To systematically review the available literature assessing the impact of LND in upper tract urothelial carcinoma (UTUC) patients.

Evidence Acquisition: Embase, Medline, and Cochrane databases were searched for all studies comparing outcomes of patients undergoing RNU without LND versus any form of LND. Read More

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http://dx.doi.org/10.1016/j.euf.2017.09.015DOI Listing
November 2017
55 Reads

Life-threatening GI bleeding secondary to multiple gastric metastases from urothelial carcinoma of the renal pelvis.

Gastrointest Endosc 2018 May 2;87(5):1362-1363. Epub 2017 Nov 2.

Department of Gastroenterology, A. Murri Hospital, Polytechnic University of Marche, Fermo, Italy.

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http://dx.doi.org/10.1016/j.gie.2017.10.013DOI Listing
May 2018
1 Read

Impact of surgical waiting time on survival in patients with upper tract urothelial carcinoma: A national cancer database study.

Urol Oncol 2018 01 12;36(1):10.e15-10.e22. Epub 2017 Oct 12.

Division of Urology, Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. Electronic address:

Purpose: To evaluate the impact of surgical waiting time (SWT) on the survival outcome in patients with upper tract urothelial carcinoma (UTUC).

Materials And Methods: We identified patients with nonmetastatic UTUC who underwent radical nephroureterectomy (RNU) between 2004 and 2013 in the National Cancer Database. The association between SWT and overall survival (OS) was evaluated using Cox proportional hazards regression. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10781439173047
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http://dx.doi.org/10.1016/j.urolonc.2017.09.013DOI Listing
January 2018
5 Reads

Metastasectomy in older adults with urothelial carcinoma: Population-based analysis of use and outcomes.

Urol Oncol 2018 01 5;36(1):9.e11-9.e17. Epub 2017 Oct 5.

Division of Hematology and Medical Oncology, Weill-Cornell Medicine, New York, NY; Department of Urology, Weill-Cornell Medicine, New York, NY. Electronic address:

Background: Metastatic urothelial carcinoma of the bladder, ureter, or renal pelvis is a highly aggressive disease with poor outcomes. Even with platinum-based chemotherapy, the median overall survival is 15 months and the 5-year survival is only 15%. The role of metastasectomy in urothelial carcinoma is currently undefined. Read More

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http://dx.doi.org/10.1016/j.urolonc.2017.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793883PMC
January 2018
7 Reads

Comprehensive Genomic Sequencing of Urothelial Tumors Identifies Rare SMARCB1 (INI-1)-Deficient Carcinomas of the Urinary System.

Clin Genitourin Cancer 2018 04 7;16(2):e373-e382. Epub 2017 Sep 7.

Foundation Medicine Inc, Cambridge, MA.

Purpose: Tumor genomic profiling helps direct therapy for advanced urothelial carcinoma (UC). In the course of clinical care, we encountered a patient with a complete loss of SMARCB1 (switch/sucrose nonfermentable-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1), which encodes INI-1 (integrase interactor 1), as the sole detected driver of their urinary tract tumor. Our objective was the identification and genomic characterization of urinary tract neoplasia with complete SMARCB1 loss. Read More

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http://dx.doi.org/10.1016/j.clgc.2017.09.001DOI Listing
April 2018
30 Reads

Transitional cell carcinoma involving graft kidney in a kidney transplant recipient: a case report.

BMC Nephrol 2017 Sep 21;18(1):299. Epub 2017 Sep 21.

Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Daejeon St. Mary's Hospital 64, Daeheung-ro, Jung-gu, Daejeon, 34943, Republic of Korea.

Background: Kidney transplantation (KT) is the treatment option for patients with end stage renal disease (ESRD) to prolong survival and improve quality of life. Although the use of potent immunosuppressive agents increases graft survival in kidney transplantation recipients (KTRs), it may lead to the development of malignancy, including transitional cell carcinoma (TCC). TCC developing in the pelvis of graft kidney is very rare in KTRs. Read More

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http://dx.doi.org/10.1186/s12882-017-0715-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609046PMC
September 2017
10 Reads

European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2017 Update.

Eur Urol 2018 01 1;73(1):111-122. Epub 2017 Sep 1.

Department of Urology, Medical University of Vienna, Vienna General Hospital, Vienna, Austria.

Context: The European Association of Urology (EAU) Guidelines Panel on Upper Urinary Tract Urothelial Carcinoma (UTUC) has prepared updated guidelines to aid clinicians in the current evidence-based management of UTUC and to incorporate recommendations into clinical practice.

Objective: To provide an overview of the EAU guidelines on UTUC as an aid to clinicians.

Evidence Acquisition: The recommendations provided in the current guidelines are based on a thorough review of available UTUC guidelines and articles identified following a systematic search of Medline. Read More

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http://dx.doi.org/10.1016/j.eururo.2017.07.036DOI Listing
January 2018
34 Reads

The role of Lutheran/basal cell adhesion molecule in human bladder carcinogenesis.

J Biomed Sci 2017 Aug 26;24(1):61. Epub 2017 Aug 26.

Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China.

Background: Lutheran/basal cell adhesion molecule (Lu/BCAM) is a membrane bound glycoprotein. This study was performed to investigate the role and downstream signaling pathway of Lu/BCAM in human bladder tumorigenesis.

Methods: Five human bladder cancer (E6, RT4, TSGH8301, TCCSUP and J82), one stable mouse fibroblast cell line (NIH-Lu) expressing Lu/BCAM transgene and sixty human uroepithelial carcinoma specimens were analyzed by real-time PCR, immunohistochemistry (IHC), immunofluorescence (IFA) staining, Western blotting and promoter luciferase assay for Lu/BCAM, respectively. Read More

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http://dx.doi.org/10.1186/s12929-017-0360-xDOI Listing
August 2017
30 Reads

Programmed Death-ligand 1 Expression in Upper Tract Urothelial Carcinoma.

Eur Urol Focus 2017 10 13;3(4-5):502-509. Epub 2016 Dec 13.

Department of Pathology, University of Michigan Health System, Ann Arbor, MI, USA; Comprehensive Cancer Center, University of Michigan Health System, Ann Arbor, MI, USA; Michigan Center for Translational Pathology, Ann Arbor, MI, USA. Electronic address:

Background: Urothelial carcinoma (UC) is the most common malignancy of the urinary tract. Upper tract (renal pelvis and ureter) urothelial carcinomas (UTUC) account for approximately 5% of UCs but a significant subset are invasive and associated with poor clinical outcomes.

Objective: To evaluate programmed death-ligand 1 (PD-L1) expression in UTUC. Read More

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http://dx.doi.org/10.1016/j.euf.2016.11.011DOI Listing
October 2017
24 Reads

Clinical and demographic characteristics among patients with urothelial carcinomas of the upper urinary tract and bladder in Taiwan.

J Chin Med Assoc 2017 Sep 24;80(9):563-568. Epub 2017 Jul 24.

Department of Urology, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, ROC; School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan, ROC. Electronic address:

Background: Urothelial carcinoma (UC) is derived from the urothelium of the urinary tract, and includes cancers of the bladder, renal pelvis and ureter. The aim of this study was to investigate the clinical and demographic features among patients with bladder cancer and urothelial carcinoma of the upper urinary tract (UTUC) in Taiwan.

Methods: The present study recruited a total of 736 histopathologically confirmed UC cases, which consisted of 470 bladder cancer and 266 UTUC between September 1998 and December 2009. Read More

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http://dx.doi.org/10.1016/j.jcma.2017.03.008DOI Listing
September 2017
14 Reads

Haematuria work-up in general care-A German observational study.

Int J Clin Pract 2017 Aug 27;71(8). Epub 2017 Jul 27.

Urological Department of the University of Duisburg-Essen, Essen, Germany.

Background: Haematuria is a common finding in the population and the diagnostic workflow of this symptom represents a large proportion of "work-load" in the urological outpatient clinic.

Aims: The intention of this study was to verify if the intensive diagnostic procedures of haematuria patients is justified by detection of a significant proportion of genito-urinary tract cancers.

Materials And Methods: In a retrospective design 1049 consecutive patients, who presented themselves with macro- or microhaematuria in the outpatient clinic PURR in the time from 2011 to 2012, were included in the study and the diagnostic procedures including ultrasound, intravenous urography, computed tomography of the abdomen and urethrocystoscopy as well as therapeutic consequences with its results were analysed. Read More

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http://dx.doi.org/10.1111/ijcp.12982DOI Listing
August 2017
20 Reads

Ureteral Involvement Is Associated with Poor Prognosis in Upper Urinary Tract Urothelial Carcinoma Patients Treated by Nephroureterectomy: A Multicenter Database Study.

Eur Urol Focus 2016 Aug 26;2(3):296-302. Epub 2015 Nov 26.

Department of Urology, Tokyo Medical and Dental University, Tokyo, Japan.

Background: The prognostic significance of tumor location for patients with upper urinary tract urothelial carcinoma (UUT-UC) has been disputed. Several papers have reported that ureteral cancer is associated with worse prognosis.

Objective: To investigate the prognostic significance of the presence of ureteral tumors in UUT-UC patients who underwent radical nephroureterectomy (RNU). Read More

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http://dx.doi.org/10.1016/j.euf.2015.10.008DOI Listing
August 2016
32 Reads

Challenges and advances in the diagnosis, biology, and treatment of urothelial upper tract and bladder carcinomas.

Urol Oncol 2017 07;35(7):462-464

GU Medical Oncology, Inova Schar Cancer Institute, Department of Medicine, Virginia Commonwealth University, Fairfax, VA. Electronic address:

Urothelial carcinomas span the bladder, ureter, and renal pelvis, and while there had been stagnation in the field of drug approval for the past two decades, there is now accelerated and regular US FDA approval of 5 immunotherapy agents. However, patients who inherently do not respond or progress on such therapies still represent an area of increased unmet need. In this special Seminars issue, we explore varying aspects of bladder urothelial carcinoma treatment with targeted therapies, the unique presentation and challenges in the treatment of upper tract and renal pelvis tumors, as well as new and emerging diagnostic imaging tools for varying genitourinary cancers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10781439173025
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http://dx.doi.org/10.1016/j.urolonc.2017.05.023DOI Listing
July 2017
6 Reads

Extraperitoneal Laparoscopic Radical Nephroureterectomy and Lymph Node Dissection in Modified Supine Position.

Urology 2017 Sep 9;107:126-131. Epub 2017 Jun 9.

the Department of Urology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Electronic address:

Objective: To explore the feasibility of extraperitoneal laparoscopic radical nephroureterectomy (EL-RNU) and lymph node dissection in a modified supine position for managing urothelial carcinomas in the renal pelvis or in the upper two-thirds of the ureter.

Patients And Methods: Consecutively from January 2014 to October 2015, 15 patients with high-risk urothelial carcinoma in the renal pelvis or in the upper two-thirds of the ureter underwent EL-RNU and extraperitoneal laparoscopic lymph node dissection (EL-LND). Clinical and pathologic data, histologic nodal status, perioperative complications, and recurrence data were collected. Read More

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http://dx.doi.org/10.1016/j.urology.2017.05.048DOI Listing
September 2017
38 Reads

Comprehensive Genomic Characterization of Upper Tract Urothelial Carcinoma.

Eur Urol 2017 10 7;72(4):641-649. Epub 2017 Jun 7.

Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Background: Upper urinary tract urothelial cancer (UTUC) may have unique etiologic and genomic factors compared to bladder cancer.

Objective: To characterize the genomic landscape of UTUC and provide insights into its biology using comprehensive integrated genomic analyses.

Design, Setting, And Participants: We collected 31 untreated snap-frozen UTUC samples from two institutions and carried out whole-exome sequencing (WES) of DNA, RNA sequencing (RNAseq), and protein analysis. Read More

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http://dx.doi.org/10.1016/j.eururo.2017.05.048DOI Listing
October 2017
35 Reads

Diagnostic utility of Ki-67 immunohistochemistry in small endoscopic biopsies of the ureter and renal pelvis.

Pathol Res Pract 2017 Jul 20;213(7):737-741. Epub 2017 Apr 20.

Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Diagnosis of upper urinary tract urothelial carcinoma in ureteroscopic biopsies is challenging. Therefore, an immunohistochemical marker that can differentiate between malignant and benign urothelium and predict final pathological features is necessary. In this study, we investigated Ki-67 expression in 26 ureteroscopic biopsies of the ureter and renal pelvis diagnosed with urothelial carcinoma (UC) and in 13 biopsies with non-neoplastic urothelium, using digital image analysis. Read More

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http://dx.doi.org/10.1016/j.prp.2017.04.009DOI Listing
July 2017
10 Reads

Nephrogenic adenoma of the urinary tract: A 6-year single center experience.

Pathol Res Pract 2017 Jul 25;213(7):831-835. Epub 2017 Mar 25.

Department of Pathology, Eskişehir Osmangazi University, Faculty of Medicine, Eskişehir, Turkey. Electronic address:

Background: Nephrogenic adenoma is an uncommon benign lesion that occurs at several sites in urinary tract, from the renal pelvis to urethra, with the highest frequency in urinary bladder. Nephrogenic adenoma displays a broad spectrum of architectural and cytological features. Hence, recognition of its characteristic histopathological features is needed to distinguish this lesion from its mimickers. Read More

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http://dx.doi.org/10.1016/j.prp.2017.03.001DOI Listing
July 2017
52 Reads

Prognostic significance of urothelial carcinoma with divergent differentiation in upper urinary tract after radical nephroureterectomy without metastatic diseases: A retrospective cohort study.

Medicine (Baltimore) 2017 May;96(21):e6945

aDepartment of Urology bTianjin Key Laboratory of Urology, Tianjin Institute of Urology, the Second Hospital of Tianjin Medical University cCollege of Management and Economics, Tianjin University, Tianjin, China.

To evaluate the impact of urothelial carcinoma with divergent differentiation (UCDD) on the prognosis of patients for primary upper urinary tract urothelial carcinoma (UTUC) with pN0/x status treated with radical nephroureterectomy (RNU) and to evaluate the prognostic value of UCDD in different tumor locations (renal pelvis and ureter).Data from a total of 346 patients with UTUC who received RNU between January 2012 and March 2016 in the institution were retrospectively analyzed. Clinicopathological features and prognostic factors age, sex, complaint, height, weight, blood pressure, tumor grade, stage, smoking status, history of adjuvant chemotherapy, tumor location, history of bladder cancer, tumor necrosis, degree of hydronephrosis, tumor size, tumor focality, and preoperative anemia were compared between patients with pure UTUC and patients with UCDD. Read More

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http://dx.doi.org/10.1097/MD.0000000000006945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457867PMC
May 2017
32 Reads

The De Ritis (aspartate transaminase/alanine transaminase) ratio as a predictor of oncological outcomes in patients after surgery for upper urinary tract urothelial carcinoma.

Int Urol Nephrol 2017 Aug 8;49(8):1383-1390. Epub 2017 May 8.

Department of Urology, Seoul National University College of Medicine, Seoul, Korea.

Purpose: Recently, several studies have shown that the De Ritis ratio (aspartate transaminase/alanine transaminase) can be a useful prognostic biomarker for certain types of malignant tumors. However, the prognostic value of the De Ritis ratio in patients with upper tract urothelial carcinoma remains largely unknown. The aim of the present study was to evaluate the prognostic significance of the De Ritis ratio in patients who had undergone radical nephroureterectomy (RNU) for upper urinary tract urothelial carcinoma. Read More

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http://dx.doi.org/10.1007/s11255-017-1613-zDOI Listing
August 2017
53 Reads

Lymphoepithelioma-like carcinoma of the upper urinary tract.

Virchows Arch 2017 Jun 28;470(6):703-709. Epub 2017 Apr 28.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.

In this report, we summarized the clinicopathologic features of ten cases of lymphoepithelioma-like carcinoma (LELC) of the upper urinary tract (ureter n = 6; renal pelvis n = 4), a rare variant of urothelial cancer characterized by a malignant epithelial component densely infiltrated by lymphoid cells. The initial diagnosis was made on radical nephrectomy in five cases, nephroureterectomy in three cases, and ureterectomy in two others. Four patients had pathologic stage T1 (n = 2) or T2 (n = 2) tumors, and six patients had stage pT3 disease. Read More

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http://dx.doi.org/10.1007/s00428-017-2117-zDOI Listing
June 2017
10 Reads

Diagnostic accuracy of upper tract urothelial carcinoma: how samples are collected matters.

Scand J Urol 2017 Apr 7;51(2):137-145. Epub 2017 Apr 7.

a Department of Oncology and Pathology , Karolinska Institutet , Stockholm , Sweden.

Objectives: The aims of this study were to determine the accuracy and reliability of cytology, histopathology and ploidy of specimens obtained at ureterorenoscopy, to evaluate the importance of how samples are collected and to determine whether cytology is an alternative to histology of biopsies.

Methods: This prospective study investigated the accuracy of grading of endoscopically taken cytology and histopathology samples from 45 consecutive patients by comparing these with subsequent nephroureterectomy specimens. Histopathology grading was done according to WHO 1999 and 2004 classifications. Read More

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http://dx.doi.org/10.1080/21681805.2017.1295102DOI Listing
April 2017
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Alcohol consumption and risk of upper-tract urothelial cancer.

Cancer Epidemiol 2017 06 29;48:36-40. Epub 2017 Mar 29.

Department of Public Health, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

Background: Upper-tract urothelial cancer (UTUC), which includes renal pelvic cancer and ureter cancer, is a rare cancer and its prognosis is poor. Smoking and high-risk occupations (e.g. Read More

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http://dx.doi.org/10.1016/j.canep.2017.03.002DOI Listing
June 2017
6 Reads

Endoscopic Treatment of Upper Tract Urothelial Carcinoma.

Curr Urol Rep 2017 Apr;18(4):31

Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.

Purpose Of Review: This study aims to make the reader be aware of recent trends regarding the endoscopic management of upper tract urothelial carcinoma (UTUC) via review of the urologic literature over the past 5 years. Given the rare incidence of this disease, and the lack of level 1 evidence, systematic reviews and meta-analyses were also evaluated. Studies of importance are also considered and outlined in the annotated reference section. Read More

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http://link.springer.com/10.1007/s11934-017-0675-x
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http://dx.doi.org/10.1007/s11934-017-0675-xDOI Listing
April 2017
10 Reads

[Endoscopic removal of papillary tumors of upper urinary tract].

Urologiia 2016 Dec(6):100-106

Research Institute of Uronephrology and Human Reproductive Health, Department and Clinic of Urology, I.M. Sechenov First MSMU.

Aim: To assess the results of organ-sparing endoscopic treatment of patients with tumors of the upper urinary tract (UUT).

Materials And Methods: Twenty four patients underwent percutaneous and ureteropyeloscopic interventions for tumors of the upper urinary tract and were followed up at the Urology Clinic, I.M. Read More

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December 2016
8 Reads

Impact of a bladder cuff excision during radical nephroureterectomy on cancer specific survival in patients with upper tract urothelial cancer in Korea: a retrospective, multi-institutional study.

Minerva Urol Nefrol 2017 Oct 14;69(5):466-474. Epub 2017 Feb 14.

Department of Urology, Kyungpook National University School of Medicine, Daegu, South Korea -

Background: Radical nephroureterectomy (RNU) with bladder cuff excision (BCE) is the surgical principle adopted for the treatment of upper tract urothelial cancers (UTUCs). However, not all RNUs are performed with BCE. We quantified the prognostic impact of RNU with BCE on cancer-specific survival (CSS) in a large patient population. Read More

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http://dx.doi.org/10.23736/S0393-2249.17.02807-7DOI Listing
October 2017
16 Reads

Prognostic Value of Leptin Receptor Overexpression in Upper Tract Urothelial Carcinomas in Taiwan.

Clin Genitourin Cancer 2017 08 11;15(4):e653-e659. Epub 2017 Jan 11.

Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Urology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:

Objectives: Leptin and its receptor (LEPR) are key players in the regulation of energy balance and body weight control and act as a growth factor for specific organs in both normal and disease states. However, LEPR accumulation may be involved in carcinogenesis, progression, and metastasis in many cancers. This study evaluated the clinical significance of LEPR expression in upper tract urothelial carcinoma (UTUC). Read More

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http://dx.doi.org/10.1016/j.clgc.2017.01.002DOI Listing
August 2017
14 Reads

Association between lymph node yield and survival among patients undergoing radical nephroureterectomy for urothelial carcinoma of the upper tract.

Cancer 2017 05 2;123(10):1741-1750. Epub 2017 Feb 2.

Urology Service, Sidney Kimmel Center for Prostate and Urologic Cancers, Memorial Sloan Kettering Cancer Center, New York, New York.

Background: Prior studies examining the value of lymph node (LN) dissection (LND) in patients with urothelial carcinoma of the upper urinary tract (UTUC) have produced conflicting results. The objective of the current study was to assess the relationship between LN yield and survival among patients undergoing radical nephroureterectomy (RNU).

Methods: The National Cancer Data Base was used to identify patients with non-metastatic UTUC who were treated with RNU between 2004 and 2012. Read More

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http://dx.doi.org/10.1002/cncr.30516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5419853PMC
May 2017
15 Reads

Anatomical templates of lymph node dissection for upper tract urothelial carcinoma: a systematic review of the literature.

Expert Rev Anticancer Ther 2017 Mar 6;17(3):235-246. Epub 2017 Feb 6.

a Department of Urology , Careggi Hospital, University of Florence , Florence , Italy.

Introduction: Indications and techniques of lymph node dissection (LND) for upper tract urothelial carcinoma (UTUC) are still controversial. Areas covered: In this study, a systematic review of the English-language literature was performed up to 1 July 2016 using the Medline, Scopus, Cochrane Library and Web of Sciences databases to provide a detailed overview of the most commonly dissected surgical templates of LND for UTUC according to laterality and location of the tumor. Overall, sixteen studies were analyzed. Read More

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http://dx.doi.org/10.1080/14737140.2017.1285232DOI Listing
March 2017
12 Reads

Safety and activity of pembrolizumab in patients with locally advanced or metastatic urothelial cancer (KEYNOTE-012): a non-randomised, open-label, phase 1b study.

Lancet Oncol 2017 Feb 10;18(2):212-220. Epub 2017 Jan 10.

University of Chicago, Chicago, IL, USA.

Background: PD-1 and its ligands are expressed in urothelial cancer, and findings have shown that inhibition of the PD-1 pathway has clinical benefit. We aimed to assess the safety and activity of an anti-PD-1 antibody pembrolizumab in patients with locally advanced or metastatic urothelial cancer.

Methods: This study was part of the non-randomised, multi-cohort, open-label, phase 1b KEYNOTE-012 basket trial. Read More

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http://dx.doi.org/10.1016/S1470-2045(17)30007-4DOI Listing
February 2017
19 Reads

Risk factors for intravesical recurrence after nephroureterectomy in patients with upper urinary tract urothelial carcinoma.

Int Urol Nephrol 2017 Mar 11;49(3):425-430. Epub 2017 Jan 11.

Division of Urology, Shizuoka Cancer Center, 1007, Shimonagakubo, Nagaizumi, Suntougun, Shizuoka, 411-8777, Japan.

Purpose: To determine major risk factors for bladder cancer (BC) recurrence after nephroureterectomy (Nux) by focusing on the pathologic appearances of tumors in upper urinary tract urothelial carcinomas (UUTUCs).

Methods: We performed 147 Nux procedures between November 2002 and September 2015. Forty-eight patients were excluded because of a history of BC (28 patients), previous or concurrent radical cystectomy (9 patients), neoadjuvant chemotherapy (5 patients), and other reasons (6 patients). Read More

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http://dx.doi.org/10.1007/s11255-017-1510-5DOI Listing
March 2017
6 Reads

Perioperative chemotherapy in upper tract urothelial carcinoma: a comprehensive review.

World J Urol 2017 Sep 10;35(9):1401-1407. Epub 2017 Jan 10.

Department of Urology, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Paris Descartes University, 27, rue du Faubourg Saint Jacques, 75014, Paris, France.

Purpose: To evaluate the role of neoadjuvant (NAC) and adjuvant chemotherapy (AC) in patients with upper tract urothelial carcinoma (UTUC) treated with radical nephroureterectomy (RNU).

Methods: A comprehensive review of the current literature was performed searching for all studies investigating NAC and AC in UTUC in MEDLINE and https://clinicaltrials.gov , prior to April 2016. Read More

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http://dx.doi.org/10.1007/s00345-016-1995-zDOI Listing
September 2017
7 Reads