557 results match your criteria Urothelial Tumors of the Renal Pelvis and Ureters


Inverted urothelial papilloma of the upper urinary tract: description of two cases with systematic literature review.

Diagn Pathol 2020 Apr 22;15(1):40. Epub 2020 Apr 22.

Pathology Section, Department of Health Sciences, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy.

Background: Inverted urothelial papilloma (IUP) of the upper urinary tract is an uncommon benign tumour that occasionally presents as a polypoid mass causing urinary obstruction. Histologically, IUP is characterised by a proliferating urothelium arranged in cords and trabeculae, in continuity with overlying intact epithelium, and extending into the lamina propria in a non-invasive, endophytic manner. Cytological atypia is minimal or absent. Read More

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http://dx.doi.org/10.1186/s13000-020-00961-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175583PMC

HER2 Status in Molecular Subtypes of Urothelial Carcinoma of the Renal Pelvis and Ureter.

Clin Genitourin Cancer 2019 Dec 13. Epub 2019 Dec 13.

Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan. Electronic address:

Introduction: Erb-b2 receptor tyrosine kinase 2 (ERBB2, also known as HER2) gene amplification or protein overexpression occurs in certain types of urothelial carcinomas. Molecular pathologic classification of urinary bladder cancer using immunohistochemistry has identified basal and luminal subtypes with differing prognoses, but the HER2 status of these subtypes has not been investigated. In addition, research on urothelial carcinoma of the renal pelvis and ureter (UCRPU) has not progressed because of its rarity, though its prognosis is worse than that of bladder cancer. Read More

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http://dx.doi.org/10.1016/j.clgc.2019.12.003DOI Listing
December 2019

Renal Pelvis Urothelial Carcinoma With Bowel Metastases.

Clin Nucl Med 2019 Dec;44(12):983-984

Oncology, Penang Adventist Hospital, George Town, Penang, Malaysia.

Urothelial carcinoma is the fourth most common genitourinary tumor with the majority of the tumor involving the urinary bladder. Only 5% involves the renal pelvis and ureter. Metastatic urothelial carcinoma of the renal pelvis frequently involves the lymph nodes, lung, liver, bone, and peritoneum. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002797DOI Listing
December 2019
1 Read

Carcinomas of the Renal Pelvis, Ureters, and Urinary Bladder Share a Carcinogenic Field as Revealed in Epidemiological Analysis of Tumor Registry Data.

Clin Genitourin Cancer 2019 12 19;17(6):436-442. Epub 2019 Jul 19.

Department of Preventive Medicine and Biostatistics, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD.

Background: Urothelial carcinomas are the most common malignant tumors in the upper and lower urinary tract. Renal cell carcinomas (RCCs) have a different pathoepidemiologic incidence and characteristics. We describe a population-based approach of differentiating between urothelial and renal carcinomas as a basis to support shared morphologic phenotypes. Read More

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http://dx.doi.org/10.1016/j.clgc.2019.07.011DOI Listing
December 2019

[Application of totally extraperitoneal renal autotransplantation with Boari flap-pelvis anastomosis in upper urinary tract urothelial carcinomas treatment].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Aug;51(4):758-763

Department of Urology, Peking University First Hospital; Institute of Urology, Peking University; National Urological Cancer Center, Beijing 100034, China.

Objective: To evaluate the feasibility and effectiveness of the totally extraperitoneal renal autotransplantation with boari flap-pelvis anastomosis in the treatment of upper urinary tract urothelial carcinoma (UTUC), and to review the experience of renal autotransplantation for UTUC treatment.

Methods: One case of applying the totally extraperitoneal renal autotransplantation with boari flap-pelvis anastomosis to the UTUC treatment was reported, and related literature was reviewed. The patient was a sixty-four-year old man who received right radical nephroureterectomy for right ureteral carcinoma 1 year before and diagnosed as left ureteral carcinoma(G2, high grade) this time. Read More

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http://dx.doi.org/10.19723/j.issn.1671-167X.2019.04.029DOI Listing
August 2019
3 Reads

Lymphadenectomy for Upper Tract Urothelial Carcinoma: A Systematic Review.

J Clin Med 2019 Aug 8;8(8). Epub 2019 Aug 8.

Department of Urology, Bichat-Claude Bernard Hospital, Assistance Publique-Hôpitaux de Paris, Paris Descartes University, 75006 Paris, France.

Background: The role of lymphonodal dissection during surgery for a tumor of the urinary tract remains controversial.

Objective: To analyze anatomical bases of lymphonodal dissection in tumors of the upper urinary tract and analyze its impact on survival, recurrence, and staging. Acquisition of data: A web-based search for scientific articles using Medline/Pubmed was carried out to identify and analyze articles on the practice and the role of lymphonodal dissection in this indication. Read More

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http://dx.doi.org/10.3390/jcm8081190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722659PMC

Invasive high-grade urothelial carcinoma of the bladder, renal pelvis, ureter, and prostatic urethra arising in a background of urothelial carcinoma with an inverted growth pattern: a contemporary clinicopathological analysis of 91 cases.

Hum Pathol 2019 10 24;92:18-24. Epub 2019 Jul 24.

Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322; Department of Urology, Emory University School of Medicine, Atlanta, GA 30322; Department of Pathology, Veterans Affairs Medical Center, Decatur, GA 30033; Winship Cancer Institute of Emory University, Atlanta, GA 30322. Electronic address:

Urothelial carcinoma with an inverted/endophytic growth pattern can occasionally mimic inverted urothelial papilloma and pose diagnostic challenges when assessing the presence or absence of invasion. Making these distinctions is critical for guiding appropriate treatment and improving patient outcomes. Here we conducted one of the largest studies to date of invasive high-grade urothelial carcinoma arising in a background of urothelial carcinoma with an inverted growth pattern. Read More

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http://dx.doi.org/10.1016/j.humpath.2019.07.005DOI Listing
October 2019

Rare case of an upper urinary tract carcinoma (UTUC) in renal pelvis and ureter associated to renal vein thrombosis: diagnostic imaging with CECT, MRI and CEUS.

J Ultrasound 2019 Sep 26;22(3):373-379. Epub 2019 Jun 26.

Department of Radiology, Azienda Ospedaliero-Universitaria Careggi, Largo G.A. Brambilla 3, 50134, Florence, Italy.

A 58-year-old woman complaining of dyspnea and mild flank pain was admitted to our radiology department after undergoing ultrasonography in another institution. She showed hydronephrosis and left kidney swelling. We performed a contrast-enhanced computed tomography (CECT) that confirmed the hydronephrosis and revealed a widely hypoperfused left kidney, a concentric thickening of the proximal ureter, and a slight and diffuse thickening of the renal pelvic wall, with a hyperdense content in the unenhanced CT phase and poor contrast enhancement in the post-contrast phases. Read More

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http://dx.doi.org/10.1007/s40477-019-00396-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704220PMC
September 2019
8 Reads

Data Set for the Reporting of Carcinoma of the Renal Pelvis and Ureter-Nephroureterectomy and Ureterectomy Specimens: Recommendations From the International Collaboration on Cancer Reporting (ICCR).

Am J Surg Pathol 2019 10;43(10):e1-e12

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, IUH Pathology Laboratory, Indianapolis, IN.

Cancer reporting guidelines have been developed and utilized in many countries throughout the world. The International Collaboration on Cancer Reporting (ICCR), through an alliance of colleges and other pathology organizations in Australasia, United Kingdom, Ireland, Europe, USA, and Canada, has developed comprehensive standardized data sets to provide for global usage and promote uniformity in cancer reporting. Structured reporting facilitates provision of all necessary information, which ensures accurate and comprehensive data collection, with the ultimate aim of improving cancer diagnostics and treatment. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001305DOI Listing
October 2019
7 Reads

Robotic radical nephroureterectomy and segmental ureterectomy for upper tract urothelial carcinoma: a multi-institutional experience.

World J Urol 2019 Nov 6;37(11):2303-2311. Epub 2019 May 6.

Sorbonne Université, GRC no 5, ONCOTYPE-URO, AP-HP, Hôpital Pitié-Salpêtrière, 75013, Paris, France.

Purpose: To report a multi-institutional experience on robotic radical nephroureterectomy (RNU) and segmental ureterectomy (SU) for upper tract urothelial carcinoma (UTUC).

Methods: Data were prospectively collected from patients with non-metastatic UTUC undergoing robotic SU or RNU at three referral centers between 2015 and 2018. Transperitoneal, single-docking robotic RNU followed established principles. Read More

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http://link.springer.com/10.1007/s00345-019-02790-y
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http://dx.doi.org/10.1007/s00345-019-02790-yDOI Listing
November 2019
28 Reads

Urothelial carcinoma with an rearrangement and response to targeted therapy.

Cold Spring Harb Mol Case Stud 2019 06 3;5(3). Epub 2019 Jun 3.

Department of Pathology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA.

Although mutations are commonly identified in many solid tumors and the response of p.V600E-positive tumors to targeted therapy is well documented, rearrangements are less frequent and are predominantly found in low-grade glioma, melanoma, lung, colorectal, and thyroid carcinoma. Preclinical and clinical studies have demonstrated effectiveness of multiple therapies (RAF-targeted, ERK-targeted, or MEK-targeted) targeting -fusion harboring tumors. Read More

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http://dx.doi.org/10.1101/mcs.a003848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549557PMC
June 2019
7 Reads

Consultation on UTUC, Stockholm 2018 aspects of risk stratification: long-term results and follow-up.

World J Urol 2019 Nov 3;37(11):2289-2296. Epub 2019 Apr 3.

Division of Urology, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.

Purpose: To summarize current knowledge on upper urinary tract carcinoma (UTUC) regarding risk stratification, long-term results, and follow-up.

Methods: A scoping review approach was applied to search literature in Pubmed, Web of Science, and Embase. Consensus was reached through discussions at Consultation on UTUC, September 2018, Stockholm. Read More

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http://dx.doi.org/10.1007/s00345-019-02739-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6825637PMC
November 2019
9 Reads

Optimal Management of Upper Tract Urothelial Carcinoma: an Unmet Need.

Curr Treat Options Oncol 2019 04 1;20(5):40. Epub 2019 Apr 1.

Department of Genitourinary Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.

Opinion Statement: Upper tract urothelial carcinoma (UTUC) is a rare genitourinary entity of the renal pelvis and the ureter characterized by a more aggressive disease phenotype when compared with urothelial carcinoma of the bladder (UCB) with more than half of UTUC cases presenting with invasive disease at diagnosis compared to 20% for bladder tumors. There is growing evidence suggesting that its distinct natural history from that of bladder cancer can be related to several genetic and epigenetic differences. Treatment of low-risk disease consists of kidney-sparing surgeries such as ureteroscopic and percutaneous treatments, segmental ureterectomy, and adjuvant topical and intracavitary chemo-immunotherapies. Read More

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http://link.springer.com/10.1007/s11864-019-0637-2
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http://dx.doi.org/10.1007/s11864-019-0637-2DOI Listing
April 2019
24 Reads

Overexpression of EIF5A2 in upper urinary tract urothelial carcinoma is a new independent prognostic marker of survival.

Future Oncol 2019 Jun 1;15(17):2009-2018. Epub 2019 Apr 1.

Department of Urology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, PR China.

To study the expression of EIF5A2 in urinary tract urothelial carcinoma and its clinicopathological features and prognosis. EIF5A2 expression was detected via immunohistochemistry in 101 patients. Kaplan-Meier analysis showed that the EIF5A2 low expression group had significantly longer overall survival (OS; p < 0. Read More

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http://dx.doi.org/10.2217/fon-2018-0748DOI Listing
June 2019
3 Reads
2.477 Impact Factor

Optimizing the Sequence of Chemotherapy for Upper Tract Urothelial Carcinoma with Clinically Positive Regional Lymph Nodes.

J Urol 2019 07 7;202(1):76-82. Epub 2019 Jun 7.

Department of Urology, Oregon Health Sciences University , Portland , Oregon.

Purpose: Upper tract urothelial carcinoma with clinically positive regional lymph nodes is an aggressive disease state with a high propensity for metastasis and death. The current literature is limited regarding national practice patterns and outcomes in this patient population.

Materials And Methods: We identified 1,658 patients in the NCDB (National Cancer Database) who had cN+M0 upper tract urothelial carcinoma. Read More

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http://dx.doi.org/10.1097/JU.0000000000000172DOI Listing
July 2019
3 Reads

[A Case of Upper Urinary Tract MALT Lymphoma with Remarkable Thickness of Renal Pelvis and Ureter Wall].

Hinyokika Kiyo 2018 Dec;64(12):489-495

The Department of Urology, Faculty of Medicine, University of Tsukuba.

A 78-year-old man was referred to Tsukuba University Hospital for right hydronephrosis. He had undergone ureteroscopy and ureteral stenting in another hospital, but no tumor was revealed in renal pelvis and ureter. The urinary cytology was negative. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_64_12_489DOI Listing
December 2018
35 Reads

Outcomes of nonmetastatic micropapillary variant upper tract urothelial carcinoma.

Urol Oncol 2019 06 16;37(6):354.e19-354.e26. Epub 2019 Feb 16.

Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

Purpose: Micropapillary variant upper tract urothelial cancer (MP-UTUC) is a rare malignancy with little known regarding its clinical course and/or optimal treatment. In this case series, we describe patient characteristics, surgical treatment, oncologic outcomes, and response to perioperative chemotherapy.

Materials And Methods: We conducted a review to identify patients with MP-UTUC treated at our center between January 1994 and October 2017. Read More

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http://dx.doi.org/10.1016/j.urolonc.2019.01.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511295PMC
June 2019
20 Reads

Multifocal Synchronous Upper Urinary Tract Carcinosarcoma (Sarcomatoid Carcinoma) With Rhabdomyoblastic Differentiation.

Int J Surg Pathol 2019 Aug 15;27(5):547-552. Epub 2019 Feb 15.

1 Department of Urology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.

Carcinosarcoma of the upper urinary tract is very rare. In this article, we report a case of upper urinary tract carcinosarcoma with rhabdomyoblastic differentiation showing distinct transition between the epithelial and mesenchymal components confirmed by morphology and immunohistochemistry. An 81-year-old female underwent radical nephroureterectomy under the diagnosis of left ureteral urothelial carcinoma (UC). Read More

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http://dx.doi.org/10.1177/1066896919828111DOI Listing
August 2019
8 Reads

8-armed octopus: Evaluation of clinicopathologic prognostic factors of urothelial carcinoma of the upper urinary system

Turk J Med Sci 2019 Feb 11;49(1):153-161. Epub 2019 Feb 11.

Background/aim: This study was designed to determine the characteristic features of upper urinary system urothelial carcinomas (UUSUCs) and to evaluate the clinicopathological parameters associated with prognosis.

Materials And Methods: A total of 74 cases of UUSUC were included, from three different centers. Demographic data and histopathological features such as tumor localization, concomitant tumor in the urinary system, distant metastasis with overall survival and disease-free survival obtained from the hospital records were evaluated retrospectively. Read More

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http://dx.doi.org/10.3906/sag-1805-51DOI Listing
February 2019
8 Reads

Contemporary best practice in the management of urothelial carcinomas of the renal pelvis and ureter.

Ther Adv Urol 2019 Jan-Dec;11:1756287218815372. Epub 2019 Jan 8.

Section of Pathological Anatomy, Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Via Conca 71, Ancona, Marche, I-60126, Italy.

Upper tract urothelial carcinoma (UTUC) accounts for 5% of urothelial carcinomas (UCs), the estimated annual incidence being 1-2 cases per 100,000 inhabitants. Similarly to bladder UC, divergent differentiations and histologic variants confer an adverse risk factor in comparison with pure UTUC. Molecular and genomic characterization studies on UTUC have shown changes occurring at differing frequencies from bladder cancer, with unique molecular and clinical subtypes, potentially with different responses to treatment. Read More

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http://dx.doi.org/10.1177/1756287218815372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329040PMC
January 2019
48 Reads

[Value of imaging in upper urinary tract tumors].

Urologe A 2019 Jan;58(1):5-13

Klinik und Poliklinik für Radiologie, Klinikum der Universität München, Campus Großhadern, München, Deutschland.

Background: Staging of bladder cancer, hematuria as well as the evaluation of unclear findings of the kidneys and ureters are the most frequent indications for imaging of the upper urinary tract (UUT). Endourological assessment of the UUT is much more invasive compared to imaging of the bladder, raising the question of the optimal imaging technique. Several technical improvements regarding computed tomography (CT) as well as magnetic resonance imaging (MRI) were implemented in recent years. Read More

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http://dx.doi.org/10.1007/s00120-018-0828-7DOI Listing
January 2019
5 Reads

High Serum CA19-9 Concentration Indicates High Chemosensitivity and Better Survival in Advanced Urothelial Carcinoma.

Anticancer Res 2019 Jan;39(1):375-380

Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.

Background: The present study was conducted to investigate whether baseline serum carbohydrate antigen (CA) 19-9 predicts prognosis or treatment effect in patients with advanced urothelial carcinoma (UC).

Materials And Methods: We retrospectively analyzed data of patients diagnosed with locally advanced or metastatic or recurrent UC between April 2008 and November 2014. CA19-9 was determined using enzyme-linked immunosorbent assay (ELISA) and the relationship between CA19-9 and prognosis were analyzed. Read More

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http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.13
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http://dx.doi.org/10.21873/anticanres.13122DOI Listing
January 2019
40 Reads

Preoperative multiplex nomogram for prediction of high-risk nonorgan-confined upper-tract urothelial carcinoma.

Urol Oncol 2019 04 22;37(4):292.e1-292.e9. Epub 2018 Dec 22.

Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

Background: Accurate risk stratification prior to radical nephroureterectomy remains a challenge with upper-tract urothelial carcinoma (UTUC). Herein, we generated an optimized preoperative tool predicting high-risk nonorgan-confined (NOC)-UTUC.

Materials And Methods: Retrospective evaluation of 699 patients undergoing radical nephroureterectomy at 3 academic centers. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10781439183049
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http://dx.doi.org/10.1016/j.urolonc.2018.12.002DOI Listing
April 2019
7 Reads

Kidney stones and the risk of renal cell carcinoma and upper tract urothelial carcinoma: the Netherlands Cohort Study.

Br J Cancer 2019 02 19;120(3):368-374. Epub 2018 Dec 19.

Department of Epidemiology, GROW - School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.

Background: We examined the association between kidney stones and renal cell carcinoma (RCC) and upper tract urothelial carcinoma (UTUC) risk in the Netherlands Cohort Study on diet and cancer.

Methods: In total, 120,852 participants aged 55-69 completed a self-administered questionnaire on diet, medical conditions and other risk factors for cancer at baseline (1986). After 20. Read More

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http://dx.doi.org/10.1038/s41416-018-0356-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353869PMC
February 2019
1 Read

Rates of lymph node invasion and their impact on cancer specific mortality in upper urinary tract urothelial carcinoma.

Eur J Surg Oncol 2019 Jul 11;45(7):1238-1245. Epub 2018 Dec 11.

Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada; Centre de recherche du Centre Hospitalier de l'Université de Montréal (CR-CHUM) and Institut du cancer de Montréal, Montréal, Québec, Canada.

Purpose: To analyze lymph node invasion (LNI) rates according to tumor characteristics and to test the impact of LNI and its extent on cancer specific mortality (CSM) in surgically-treated non metastatic urothelial upper urinary tract carcinoma (UTUC) patients.

Materials And Methods: Within the SEER database (2004-2014), we identified 2098 patients with histologically confirmed non-metastatic urothelial carcinoma of renal pelvis or ureter who underwent NU with LND. LNI rates stratified according to tumor location and stage were described. Read More

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http://dx.doi.org/10.1016/j.ejso.2018.12.004DOI Listing
July 2019
10 Reads

Clinical utility and concordance of upper urinary tract cytology and biopsy in predicting clinicopathological features of upper urinary tract urothelial carcinoma.

Hum Pathol 2019 04 8;86:76-84. Epub 2018 Dec 8.

Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA; Michigan Center for Translational Pathology, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:

Five percent of urothelial carcinoma occurs in the upper urinary tract (UUT), a challenging location to biopsy. We aim to evaluate concordance between biopsy, cytology, and resection specimens in a large upper tract urothelial carcinoma (UTUC) cohort. One hundred seventeen UTUC resections with UUT biopsy and/or cytology specimens from 2000 to 2016 were retrieved; pathologic material was re-reviewed, evaluated for concordance, and correlated with clinical information. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.11.021DOI Listing
April 2019
43 Reads

Tumors of Renal Collecting Systems, Renal Pelvis, and Ureters: Role of MR Imaging and MR Urography Versus Computed Tomography Urography.

Magn Reson Imaging Clin N Am 2019 Feb;27(1):15-32

Abdominal Imaging Division, UT Southwestern University Hospitals, 5323 Harry Hines Boulevard, Dallas, TX 75390-8827, USA.

Hematuria evaluation remains a common problem, particularly in patients who smoke and are at risk for urothelial tumors. Lifetime surveillance of the urothelium is often required once urothelial cancer is diagnosed. Computed tomography urography (CTU) has exquisite sensitivity and specificity for identification of renal and urothelial lesions. Read More

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http://dx.doi.org/10.1016/j.mric.2018.09.002DOI Listing
February 2019
23 Reads

The detection of PAX8 in human upper urinary tract urothelial carcinoma.

Int J Clin Exp Pathol 2018 1;11(11):5394-5400. Epub 2018 Nov 1.

Department of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University Hangzhou, Zhejiang Province, China.

Upper urinary tract urothelial carcinomas (UUT-UCs) are defined as malignant neoplasms of the urothelium from the upper urinary tract, including renal calyces, the renal pelvis and the distal ureter. The natural attributes of UUT-UCs differ from those of bladder cancer. The aim of the present study was to investigate PAX8 expression in the normal urothelium and in urothelial carcinomas (UCs) of the upper urinary tract. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963013PMC
November 2018

Recent advances in upper tract urothelial carcinomas: From bench to clinics.

Int J Urol 2019 02 29;26(2):148-159. Epub 2018 Oct 29.

Division of Urology, Department of Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Urothelial carcinoma in the upper tract is rare and often discussed separately. Many established risk factors were identified for the disease, including genetic and external risk factors. Radiographic survey, endoscopic examination and urine cytology remained the most important diagnostic modalities. Read More

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http://doi.wiley.com/10.1111/iju.13826
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http://dx.doi.org/10.1111/iju.13826DOI Listing
February 2019
28 Reads

Systematic review and two new cases of primary upper urinary tract neuroendocrine carcinomas.

Cancer Treat Res Commun 2018 9;17:23-30. Epub 2018 Oct 9.

Department of Urology, Showa University, School of Medicine, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan. Electronic address:

Background: Upper urinary tract neuroendocrine carcinoma (UUT-NEC) is extremely rare and has a poor prognosis. Although a few cases of successful treatment have been reported, no treatment has shown established efficacy.

Patients And Methods: We analyzed 70 UUT-NEC patients, including 68 with small cell neuroendocrine carcinoma (SCNEC) and large cell neuroendocrine carcinoma (LCNEC) reported between 1985 and 2017 and 2 treated at our hospital. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S24682942183009
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http://dx.doi.org/10.1016/j.ctarc.2018.10.003DOI Listing
May 2019
16 Reads

RETRACTED: Recommandations françaises du Comité de Cancérologie de l’AFU — Actualisation 2018—2020 : tumeurs de la voie excrétrice supérieure French ccAFU guidelines — Update 2018—2020: Upper tract urothelial carcinoma

Prog Urol 2018 11 11;28(12S):S32-S45. Epub 2018 Oct 11.

Comité de cancérologie de l'Association française d'urologie, groupe vessie, Maison de l'Urologie, 11, rue Viète, 75017 Paris, France; Service d'urologie, hôpital Européen-Georges-Pompidou, université Paris Descartes, AP-HP, 75015 Paris, France.

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S11667087183046
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http://dx.doi.org/10.1016/j.purol.2018.07.284DOI Listing
November 2018
24 Reads

Treatment utilization and overall survival in patients receiving radical nephroureterectomy versus endoscopic management for upper tract urothelial carcinoma: evaluation of updated treatment guidelines.

World J Urol 2019 Jun 28;37(6):1157-1164. Epub 2018 Sep 28.

Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Purpose: While radical nephroureterectomy (RNU) is the gold standard treatment for upper tract urothelial carcinoma (UTUC), select patients may benefit from endoscopic treatment (ET). European Association of Urology guidelines recommend ET for patients with low-risk (LR) disease: unifocal, < 2 cm, low-grade lesions without local invasion. To inform the utility of ET, we compare the overall survival (OS) of patients receiving ET and RNU using current and previous guidelines of LR disease. Read More

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http://dx.doi.org/10.1007/s00345-018-2506-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438772PMC
June 2019
34 Reads

Evaluation of upper tract urothelial carcinomas by contrast-enhanced ultrasound.

Radiologia 2018 Nov - Dec;60(6):496-503. Epub 2018 Sep 25.

Servicio de Radiodiagnóstico, Hospital Universitario Doctor Peset, Valencia, España.

Aim: To describe the findings and behaviour of contrast-enhanced ultrasound in the study of upper tract urothelial tumours and to assess its usefulness for diagnosis.

Material And Methods: We reviewed our hospital's database over a period of 45 months to identify patients diagnosed with upper tract urothelial carcinomas. We reviewed the findings on mode B-ultrasound, contrast-enhanced ultrasound (location and qualitative assessment of intensity and washout of enhancement), and made a comparison with other techniques (computed tomography or magnetic resonance), and with the surgical specimen. Read More

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http://dx.doi.org/10.1016/j.rx.2018.07.005DOI Listing
June 2019
28 Reads

Fibroblast growth factor receptor 3 (FGFR3) aberrations in muscle-invasive urothelial carcinoma.

BMC Urol 2018 Jul 31;18(1):68. Epub 2018 Jul 31.

Division of Hematology-Oncology, Department of Medicine, Sungkyunkwan University Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, South Korea.

Background: Recent studies suggest that FGFR3 is a potential therapeutic target in urothelial carcinoma (UC). The purpose of this study was to evaluate the rates and types of FGFR3 aberrations in patients with muscle-invasive UC who received radical resection.

Methods: We analyzed surgical tumor samples from 74 UC patients who had received radical cystectomy (n = 40) or ureteronephrectomy (n = 34). Read More

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http://dx.doi.org/10.1186/s12894-018-0380-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6069868PMC
July 2018
26 Reads

Novel therapies in urothelial carcinoma: a biomarker-driven approach.

Ann Oncol 2018 12;29(12):2302-2312

Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, USA. Electronic address:

Urothelial malignancies, including carcinomas of the bladder, ureters, and renal pelvis comprised ∼8% of new cancer cases in the USA in 2016. In the metastatic setting, 15% of patients exhibit long-term survival following cisplatin-based chemotherapy and in patients with recurrent disease, response rates to second-line chemotherapy are generally 15%-20% with a 3-month progression-free survival. However, recent advances in immunotherapy represent an opportunity to significantly improve patient outcomes. Read More

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http://dx.doi.org/10.1093/annonc/mdy254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6887951PMC
December 2018
1 Read

Risk factors for bladder cancer recurrence survival in patients with upper-tract urothelial carcinoma.

Tumori 2018 Dec 8;104(6):451-458. Epub 2018 May 8.

Departments of Urology, First Affiliated Hospital of Fujian Medical University, Fuzhou - PR China.

Purpose: The aim of this work was to investigate the predictive factors for bladder cancer recurrence survival (BCRS) in patients with upper-tract urothelial carcinoma (UTUC).

Methods: We selected patients with UTUC who underwent segmental ureterectomy (Su) or nephroureterectomy (Nu) from 2004 to 2013 from the Surveillance, Epidemiology, and End Results (SEER) database. Patients with a history of intravesical therapy for bladder cancer and bladder cancer prior to the diagnosis of UTUC were excluded. Read More

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http://dx.doi.org/10.5301/tj.5000705DOI Listing
December 2018
32 Reads

Coincidental Bladder Cuff Transitional Cell Carcinoma in Nephroureterectomy Specimens: Risk Factors, Prognosis and Clinical Implementation.

Urol J 2018 Sep 26;15(5):256-260. Epub 2018 Sep 26.

Mafraq Hospital, United Arab Emirates.

Purpose: There is a lack of reporting of the bladder cuff pathology in the literature and ongoing debate regarding the role of bladder cuff excision (BCE) in the prognosis in patients with upper tract urothelial carcinoma (UTUC). We aimed to know the risk factors, the survival, and the clinical course of such pathology.

Materials And Methods: The study was retrospective, from 1983-2013 on 305 patients who had diagnosed with UTUC. Read More

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http://dx.doi.org/10.22037/uj.v0i0.4069DOI Listing
September 2018
19 Reads

Comparison of clinicopathologic characteristics, epigenetic biomarkers and prognosis between renal pelvic and ureteral tumors in upper tract urothelial carcinoma.

BMC Urol 2018 Mar 27;18(1):22. Epub 2018 Mar 27.

Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Centre, No. 8 Xishiku St, Xicheng District, Beijing, 100034, China.

Background: There's no consensus about the difference between renal pelvic and ureteral tumors in terms of clinical features, pathological outcomes, epigenetic biomarkers and prognosis.

Methods: The data of 341 patients with renal pelvic tumors and 271 patients with ureteral tumors who underwent radical nephroureterectomy between 1999 and 2011 were retrospectively reviewed. The clinicopathologic features, gene promoters methylation status and oncologic outcomes were compared. Read More

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http://dx.doi.org/10.1186/s12894-018-0334-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5870733PMC
March 2018
7 Reads

Ki-67 as a Prognostic Marker in Upper Urinary Tract Urothelial Carcinoma: A Systematic Review and Meta-Analysis.

Clin Genitourin Cancer 2018 08 24;16(4):e831-e841. Epub 2018 Feb 24.

Department of Urology, Seoul National University Hospital, Seoul, Korea. Electronic address:

Background: We systematically evaluated the prognostic significance of Ki-67 on survival outcomes in patients with upper urinary tract urothelial carcinoma (UTUC) treated with radical nephroureterectomy (RNU).

Materials And Methods: We searched the Embase, Scopus, and PubMed databases for all articles published up to February 2017 by following the Preferred Reporting Items for Systematic Review and Meta-analyses guidelines. The outcomes of interest included intravesical recurrence (IVR)-free survival, disease-free survival (DFS), cancer-specific survival (CSS), and overall survival (OS). Read More

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http://dx.doi.org/10.1016/j.clgc.2018.02.010DOI Listing
August 2018
22 Reads

study in nephroureterectomy specimens defining the role of 3-D upper urinary tract visualization using optical coherence tomography and endoluminal ultrasound.

J Med Imaging (Bellingham) 2018 Jan 12;5(1):017001. Epub 2018 Feb 12.

University of Amsterdam, Academic Medical Center, Department of Biomedical Engineering and Physics, Amsterdam, The Netherlands.

Minimal invasive endoscopic treatment for upper urinary tract urothelial carcinoma (UUT-UC) is advocated in patients with low-risk disease and limited tumor volume. Diagnostic ureterorenoscopy combined with biopsy is the diagnostic standard. This study aims to evaluate two alternative diagnostic techniques for UUT-UC: optical coherence tomography (OCT) and endoluminal ultrasound (ELUS). Read More

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http://dx.doi.org/10.1117/1.JMI.5.1.017001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808355PMC
January 2018
28 Reads

Comparison of Pathological Stage in Patients Treated with and without Neoadjuvant Chemotherapy for High Risk Upper Tract Urothelial Carcinoma.

J Urol 2018 07 4;200(1):68-73. Epub 2018 Jan 4.

Department of Urology, The James Buchanan Brady Urological Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland; The Greenberg Bladder Cancer Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland.

Purpose: High risk upper tract urothelial carcinoma has been associated with poor survival outcomes. Limited retrospective data support neoadjuvant chemotherapy prior to radical nephroureterectomy. To validate prior findings we evaluated differences in the pathological stage distribution in patients with high risk upper tract urothelial carcinoma based on the administration of neoadjuvant chemotherapy before radical nephroureterectomy. Read More

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http://dx.doi.org/10.1016/j.juro.2017.12.054DOI Listing
July 2018
26 Reads

Association between urologic malignancies and end-stage renal disease: A meta-analysis.

Nephrology (Carlton) 2019 Jan;24(1):65-73

Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Aim: Previous studies have suggested a higher incidence of urologic malignancies in end-stage renal disease (ESRD) patients. However, incidence trends of urologic malignancies in ESRD patients remain unclear. The aims of the present study were: (i) to investigate the pooled incidence/incidence trends; and (ii) to assess the risk of urologic malignancies in ESRD patients. Read More

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http://dx.doi.org/10.1111/nep.13209DOI Listing
January 2019
15 Reads

Standardized and Simplified Retroperitoneal Lymph Node Dissection During Retroperitoneal Laparoscopic Radical Nephroureterectomy for Urothelial Carcinoma of the Upper Ureter or Renal Pelvis: En Bloc Resection Technique.

Urology 2018 Feb 20;112:85-91. Epub 2017 Nov 20.

Department of Urology, Ijinkai Takeda General Hospital, Kyoto, Japan.

Objective: To describe our en bloc technique of retroperitoneal lymph node dissection (RPLND) during retroperitoneal laparoscopic radical nephroureterectomy for upper urinary tract urothelial carcinoma and evaluate perioperative outcomes.

Methods: From 2002 to 2015, 114 patients with urinary tract urothelial carcinoma located at the pelvis or upper or middle ureter underwent retroperitoneal laparoscopic radical nephroureterectomy at 2 institutions. Performance of RPLND began in February 2009. Read More

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http://dx.doi.org/10.1016/j.urology.2017.11.001DOI Listing
February 2018
26 Reads

Potential Benefit of Lymph Node Dissection During Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: A Systematic Review by the European Association of Urology Guidelines Panel on Non-muscle-invasive Bladder Cancer.

Eur Urol Focus 2019 03 20;5(2):224-241. Epub 2017 Nov 20.

Academic Department of Urology, La Pitié-Salpétrière Hospital, Assistance-Publique Hôpitaux de Paris, Paris, France.

Context: The oncological efficacy of routine lymphadenectomy (lymph node dissection [LND]) at the time of radical nephroureterectomy (RNU) remains controversial.

Objective: To systematically review the available literature assessing the impact of LND in upper tract urothelial carcinoma (UTUC) patients.

Evidence Acquisition: Embase, Medline, and Cochrane databases were searched for all studies comparing outcomes of patients undergoing RNU without LND versus any form of LND. Read More

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http://dx.doi.org/10.1016/j.euf.2017.09.015DOI Listing
March 2019
88 Reads

Life-threatening GI bleeding secondary to multiple gastric metastases from urothelial carcinoma of the renal pelvis.

Gastrointest Endosc 2018 May 2;87(5):1362-1363. Epub 2017 Nov 2.

Department of Gastroenterology, A. Murri Hospital, Polytechnic University of Marche, Fermo, Italy.

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http://dx.doi.org/10.1016/j.gie.2017.10.013DOI Listing
May 2018
4 Reads

Impact of contemporary patterns of chemotherapy utilization on survival in patients with advanced cancer of the urinary tract: a Retrospective International Study of Invasive/Advanced Cancer of the Urothelium (RISC).

Ann Oncol 2018 02;29(2):361-369

Mount Sinai School of Medicine, Tisch Cancer Institute, New York, USA.

Background: Cisplatin-based combination chemotherapy is the standard treatment of advanced urinary tract cancer (aUTC), but 50% of patients are ineligible for cisplatin according to recently published criteria. We used a multinational database to study patterns of chemotherapy utilization in patients with aUTC and determine their impact on survival.

Patients And Methods: This was a retrospective study of patients with: UTC (bladder, renal pelvis, ureter or urethra); advanced disease (stages T4b and/or N+ and/or M+); urothelial, squamous or adenocarcinoma histology. Read More

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https://academic.oup.com/annonc/article/29/2/361/4565502
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http://dx.doi.org/10.1093/annonc/mdx692DOI Listing
February 2018
7 Reads

Impact of surgical waiting time on survival in patients with upper tract urothelial carcinoma: A national cancer database study.

Urol Oncol 2018 01 12;36(1):10.e15-10.e22. Epub 2017 Oct 12.

Division of Urology, Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. Electronic address:

Purpose: To evaluate the impact of surgical waiting time (SWT) on the survival outcome in patients with upper tract urothelial carcinoma (UTUC).

Materials And Methods: We identified patients with nonmetastatic UTUC who underwent radical nephroureterectomy (RNU) between 2004 and 2013 in the National Cancer Database. The association between SWT and overall survival (OS) was evaluated using Cox proportional hazards regression. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10781439173047
Publisher Site
http://dx.doi.org/10.1016/j.urolonc.2017.09.013DOI Listing
January 2018
8 Reads

Metastasectomy in older adults with urothelial carcinoma: Population-based analysis of use and outcomes.

Urol Oncol 2018 01 5;36(1):9.e11-9.e17. Epub 2017 Oct 5.

Division of Hematology and Medical Oncology, Weill-Cornell Medicine, New York, NY; Department of Urology, Weill-Cornell Medicine, New York, NY. Electronic address:

Background: Metastatic urothelial carcinoma of the bladder, ureter, or renal pelvis is a highly aggressive disease with poor outcomes. Even with platinum-based chemotherapy, the median overall survival is 15 months and the 5-year survival is only 15%. The role of metastasectomy in urothelial carcinoma is currently undefined. Read More

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http://dx.doi.org/10.1016/j.urolonc.2017.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5793883PMC
January 2018
15 Reads

Treatment for presumed BK polyomavirus nephropathy and risk of urinary tract cancers among kidney transplant recipients in the United States.

Am J Transplant 2018 01 1;18(1):245-252. Epub 2017 Nov 1.

National Cancer Institute, Bethesda, MD, USA.

Recent case series describe detection of BK polyomavirus (BKV) in urinary tract cancers in kidney transplant recipients, suggesting that BKV could contribute to the development of these cancers. We assessed risk for urinary tract cancers in kidney recipients with or without treatment for presumed BKV nephropathy (tBKVN) using data from the United States Transplant Cancer Match Study (2003-2013). Among 55 697 included recipients, 2015 (3. Read More

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http://dx.doi.org/10.1111/ajt.14530DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739985PMC
January 2018
4 Reads