15,432 results match your criteria Urothelial Tumors of the Renal Pelvis and Ureters


Sarcomatoid Carcinoma of Urinary Bladder: a Case Report.

Indian J Surg Oncol 2018 Dec 16;9(4):644-646. Epub 2018 May 16.

Department of Surgical Oncology, Bombay Hospital, Bombay Hospital Marg, Marine Drive, Mumbai, 400020 India.

Sarcomatoid carcinoma is an extremely rare aggressive tumor variant comprising about 0.3% of all primary tumors of the urinary bladder and carries an overall dismal prognosis. Diagnosis is important and is sometimes difficult. Read More

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December 2018

Immunoexpression of N-cadherin, Twist and Vimentin in Bladder Urothelial Carcinomas.

Curr Health Sci J 2015 Jul-Sep;41(3):219-226. Epub 2015 Jan 29.

Pathology Department, University of Medicine and Pharmacy of Craiova, Romania.

Purpose: Epithelial mesenchymal transition consists in the acquisition of neoplastic epithelial cells of a mesenchymal phenotype the process being involved in cancers invasion and metastasis. In this study were analyzed the expression of N-cadherin, Twist and Vimentin in bladder urothelial carcinomas according to the main prognostic parameters.

Material/methods: The study included 20 bladder urothelial carcinomas which were analyzed histopathological, immunohistochemical and statistical. Read More

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January 2015

Atypical morphology and myocardial perfusion of mid-ventricular ballooning: A case report.

J Cardiol Cases 2012 Sep 6;6(3):e70-e74. Epub 2012 Jun 6.

Cardiovascular Division, Department of Medicine II, Kansai Medical University, Hirakata, Osaka, Japan.

Although some atypical types of transient left ventricular apical ballooning syndrome have been reported, only a few atypical types of transient mid-ventricular ballooning have been reported. A 70-year-old female underwent surgery for urothelial carcinoma. At day 5 after the surgery, she was admitted to our department without cardiac symptoms because of ST elevation in leads I, II, III, aVF and V1-V6 indicating acute coronary syndrome. Read More

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September 2012
1 Read

Clinical utility and concordance of upper urinary tract cytology and biopsy in predicting Clinicopathologic features of upper urinary tract urothelial carcinoma.

Hum Pathol 2018 Dec 8. Epub 2018 Dec 8.

Department of Pathology, University of Michigan, 2800 Plymouth Road, Building 35, Ann Arbor, MI 48109, USA; Michigan Center for Translational Pathology, 5309 CCC 5940, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109, USA; Comprehensive Cancer Center, University of Michigan Medical School, 1500 E Medical Center Drive, Ann Arbor, MI, 48109, USA. Electronic address:

5% of urothelial carcinoma occurs in the upper urinary tract (UUT), a challenging location to biopsy. We aim to evaluate concordance between biopsy, cytology, and resection specimens in a large upper tract urothelial carcinoma (UTUC) cohort.117 UTUC resections with UUT biopsy and/or cytology specimens from 2000-2016 were retrieved; pathologic material was re-reviewed, evaluated for concordance, and correlated with clinical information. Read More

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December 2018

Novel nomograms to predict recurrence and progression in primary non-muscle-invasive bladder cancer: validation of predictive efficacy in comparison with European Organization of Research and Treatment of Cancer scoring system.

World J Urol 2018 Dec 10. Epub 2018 Dec 10.

Department of Urology, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Korea.

Purpose: To develop and validate novel nomograms to predict recurrence and progression after transurethral resection of bladder tumor (TURBT) in Korean patients with non-muscle-invasive bladder cancer (NMIBC).

Methods: We retrospectively analyzed the clinical data on 970 newly diagnosed NMIBC patients after TURBT between 2000 and 2013 in a single institution. We used multivariate Cox proportional hazard models to identify the significant predictors of recurrence and progression, which resulted in the construction of the nomograms predicting the 5-year probability of recurrence and progression. Read More

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December 2018
2 Reads

Positive ureteric margins at radical cystectomy: Can it be predicted at initial transurethral resection of bladder tumour?

Arab J Urol 2018 Dec 14;16(4):386-390. Epub 2018 Jul 14.

Department of Urology, Christian Medical College and Hospital, Vellore, Tamilnadu, India.

Objective: To identify primary tumour-related factors at transurethral resection of bladder tumour (TURBT) that may predict positive distal ureteric margins (PUM) at the time of radical cystectomy (RC).

Patients And Methods: A retrospective, cohort study was conducted using our institution's data from June 2007 to June 2016. Patients who underwent TURBT followed by RC for non-metastatic urothelial carcinoma (UC) of the bladder were identified. Read More

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December 2018

Performance of the Food and Drug Administration/EMA-approved programmed cell death ligand-1 assays in urothelial carcinoma with emphasis on therapy stratification for first-line use of atezolizumab and pembrolizumab.

Eur J Cancer 2018 Dec 5;106:234-243. Epub 2018 Dec 5.

Institute of Pathology, Technical University Munich, Munich, Germany. Electronic address:

Background: Recently, the Food and Drug Administration (FDA)/European Medicines Agency (EMA) restricted first-line use of atezolizumab and pembrolizumab in patients with metastasised urothelial carcinoma by defining distinct programmed cell death ligand-1 cut-offs. We analysed the diagnostic performance of all FDA/EMA-approved programmed cell death ligand-1 assays with emphasis on new restrictions for first-line treatment with atezolizumab and pembrolizumab.

Patients And Methods: Two hundred fifty-one urothelial carcinomas were analysed on tissue microarrays with four cores of each tumour. Read More

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December 2018

Effect of PD-L1 testing on the cost-effectiveness and budget impact of pembrolizumab for advanced urothelial carcinoma of the bladder in the United States.

Urol Oncol 2018 Dec 6. Epub 2018 Dec 6.

Institute for Technology Assessment, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA. Electronic address:

Purpose: Our purpose was to evaluate the effect of PD-L1 testing on the cost-effectiveness of pembrolizumab for second-line treatment of advanced urothelial carcinoma in the bladder from the U.S. societal perspective. Read More

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December 2018

Reply to Pontus Eriksson and Gottfrid Sjödahl's Letter to the Editor re: Tuan Zea Tan, Mathieu Rouanne, Kien Thiam Tan, Ruby Yun-Ju Huang, Jean-Paul Thiery. Molecular Subtypes of Urothelial Bladder Cancer: Results from a Meta-cohort Analysis of 2411 Tumors. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2018.08.027.

Eur Urol 2018 Dec 5. Epub 2018 Dec 5.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Guangzhou Institute of Biomedicine and Health, Chinese Academy of Science, Guangzhou, People's Republic of China; CNRS Emeritus CNRS UMR 7057 Matter and Complex Systems, University Paris Denis Diderot, Paris, France; INSERM UMR 1186, Integrative Tumor Immunology and Genetic Oncology, Gustave Roussy, Université Paris-Saclay, Villejuif, France. Electronic address:

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December 2018

More Extensive Lymph Node Dissection Improves Survival Benefit of Radical Cystectomy in Metastatic Urothelial Carcinoma of the Bladder.

Clin Genitourin Cancer 2018 Nov 17. Epub 2018 Nov 17.

Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada.

Background: Radical cystectomy (RC) may occasionally be performed in individuals with metastatic urothelial carcinoma of the bladder (mUCB). However, the role of lymph node dissection (LND) for such cases is unknown. Thus, we tested the effect of RC on cancer-specific mortality (CSM) and overall mortality in mUCB patients and the effect of LND and its extent on CSM. Read More

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November 2018

Re: "Monopolar vs. bipolar transurethral resection for nonmuscle invasive bladder carcinoma: A post hoc analysis from a randomized controlled trial".

Urol Oncol 2018 Dec 4. Epub 2018 Dec 4.

University of Health Sciences, Izmir Bozyaka Training and Research Hospital Department of Urology, Izmir, Turkey.

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December 2018

Human papillomavirus and squamous cell carcinoma of the urinary bladder: DaBlaCa-10 study.

Scand J Urol 2018 Dec 11:1-6. Epub 2018 Dec 11.

a Department of Urology , Aarhus University Hospital , Denmark.

Objective: To evaluate a potential association between Human Papillomavirus (H.P.V. Read More

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December 2018

ATF2 promotes urothelial cancer outgrowth via cooperation with androgen receptor signaling.

Endocr Connect 2018 Dec;7(12):1397-1408

Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA.

We investigated the functional role of ATF2, a transcription factor normally activated via its phosphorylation in response to phospho-ERK/MAPK signals, in the outgrowth of urothelial cancer. In both neoplastic and non-neoplastic urothelial cells, the expression levels of androgen receptor (AR) correlated with those of phospho-ATF2. Dihydrotestosterone treatment in AR-positive bladder cancer cells also induced the expression of phospho-ATF2 and phospho-ERK as well as nuclear translocation and transcriptional activity of ATF2. Read More

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December 2018
1 Read

Immunomodulatory response of layered small intestinal submucosa in a rat bladder regeneration model.

J Biomed Mater Res B Appl Biomater 2018 Dec 6. Epub 2018 Dec 6.

Department of Urology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104.

Based on the hypothesis that bioscaffold permeability is a major factor in determining the outcome of histologically complete and functional bladder regeneration, we evaluated regeneration processes of four-layer porcine small intestinal submucosa (SIS) construct; and compared results between rat bladders augmented with single-layer SIS bioscaffolds. Sprague-Dawley female rats were subjected to hemi-cystectomy followed by anastomosis of a patch of either single- or four-layer porcine SIS. Permeability was analyzed in situ using magnetic resonance imaging (MRI) at post-operative days 7 and 14. Read More

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December 2018
5 Reads

Extramammary Paget ’s disease Of Glans Penis: A Rare Case Report

Ir Med J 2018 06 7;111(6):772. Epub 2018 Jun 7.

Department of Urological Surgery, Tallaght Hospital, Dublin 24

We present the case of an 83-year-old man with Extramammary Paget’s disease (EMPD) of the penis. He underwent a total penectomy and histopathology confirms the association of underlying invasive high grade urothelial carcinoma. Penile EMPD is rare and can be misinterpreted for benign skin conditions. Read More

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June 2018
1 Read

Investigation of tolerability and quality of life for carboplatin-based chemotherapy in an elderly urothelial carcinoma patient undergoing hemodialysis: a case report.

J Pharm Health Care Sci 2018 29;4:29. Epub 2018 Nov 29.

1Department of Pharmacy, Nagoya City University Hospital, 1-Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8602 Japan.

Background: To our knowledge, no studies have evaluated the safety of carboplatin (CBDCA)-based chemotherapy in hemodialysis patients > 80 years-old. In addition, the impact of CBDCA-based chemotherapy on such elderly patients' quality of life (QOL) is unknown. We report a case of gemcitabine plus CBDCA chemotherapy treatment in an 81-year-old man with metastatic urothelial carcinoma undergoing hemodialysis. Read More

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November 2018

CD4+ T cells induce rejection of urothelial tumors after immune checkpoint blockade.

JCI Insight 2018 Dec 6;3(23). Epub 2018 Dec 6.

Department of Internal Medicine, Division of Oncology.

Immune checkpoint blockade (ICB) provides clinical benefit to a minority of patients with urothelial carcinoma (UC). The role of CD4+ T cells in ICB-induced antitumor activity is not well defined; however, CD4+ T cells are speculated to play a supportive role in the development of CD8+ T cells that kill tumor cells after recognition of tumor antigens presented by MHC class I. To investigate the mechanisms of ICB-induced activity against UC, we developed mouse organoid-based transplantable models that have histologic and genetic similarity to human bladder cancer. Read More

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December 2018
2 Reads

The Role of Glucocorticoid Receptor Signaling in Bladder Cancer Progression.

Cancers (Basel) 2018 Dec 4;10(12). Epub 2018 Dec 4.

Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA.

Previous preclinical studies have indicated that the activation of glucocorticoid receptor signaling results in inhibition of the growth of various types of tumors. Indeed, several glucocorticoids, such as dexamethasone and prednisone, have been prescribed for the treatment of, for example, hematological malignancies and castration-resistant prostate cancer. By contrast, the role of glucocorticoid-mediated glucocorticoid receptor signaling in the progression of bladder cancer remains far from being fully understood. Read More

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December 2018

Percutaneous drainage and management of fluid collections associated with necrotic or cystic tumors in the abdomen and pelvis.

Abdom Radiol (NY) 2018 Nov 30. Epub 2018 Nov 30.

Department of Radiology, Louisiana State University Health, Shreveport, LA, USA.

Purpose: The purpose of the study was to evaluate the efficacy and safety of percutaneous drainage for palliation of symptoms and sepsis in patients with cystic or necrotic tumors in the abdomen and pelvis.

Materials And Methods: This is a single center retrospective study of 36 patients (18 men, mean age = 51.1 years) who underwent percutaneous drainage for management of cystic or necrotic tumors in the non-postoperative setting over an 11-year period. Read More

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November 2018
1 Read

Vulvar Extramammary Paget's Disease Secondary to Urothelial Carcinoma Presenting with a Small Painful Erosion of the Vulva.

Indian Dermatol Online J 2018 Nov-Dec;9(6):471-473

Department of Dermatology, National Cheng Kung University Hospital, Tainan, Taiwan.

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December 2018
1 Read

An unusual case of high grade papillary urothelial carcinoma of renal pelvis revealed by a solitary central nervous system metastasis.

Urol Case Rep 2019 Mar 21;23:15-16. Epub 2018 Nov 21.

Department of Neurosurgery - UHC Habib Bourguiba, Sfax, Tunisia.

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March 2019
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Bladder Carcinoma Presenting as Paget's Disease of Vulva: An Uncommon Entity.

Indian J Dermatol 2018 Nov-Dec;63(6):518-520

Departments of Laboratory Services, Rajiv Gandhi Cancer Institute and Research Center, New Delhi, India.

Paget's disease of the vulva is a rare intraepithelial neoplasm, accounting for <5% of all vulvar lesions. The underlying mechanisms of this disease are still poorly understood, however, diagnosing a Pagetoid lesion early is of prime importance as it may forewarn an underlying systemic malignancy. We discuss the case of an elderly female who was being conservatively treated for infectious lesion of the lower urinary tract and vulva for months. Read More

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December 2018
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Prognostic Factors and a Survival Score in Patients Irradiated for Metastatic Epidural Spinal Cord Compression from Urothelial Carcinoma Cancer of the Bladder.

Anticancer Res 2018 Dec;38(12):6841-6846

Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, U.S.A.

Background/aim: Prognoses of patients with metastatic epidural spinal cord compression (MESCC) from urothelial carcinoma of the bladder are generally poor. This study aimed to identify prognostic factors that can facilitate personalized care of these patients.

Patients And Methods: In 46 patients, 10 factors were evaluated for overall response (OR), post-radiotherapy (RT) ambulatory status, local control of MESCC and overall survival (OS). Read More

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December 2018
1 Read

Activity of durvalumab plus olaparib in metastatic castration-resistant prostate cancer in men with and without DNA damage repair mutations.

J Immunother Cancer 2018 Dec 4;6(1):141. Epub 2018 Dec 4.

Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Background: Checkpoint inhibitors have not been effective for prostate cancer as single agents. Durvalumab is a human IgG1-K monoclonal antibody that targets programmed death ligand 1 and is approved by the U.S. Read More

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December 2018
3 Reads

DNA replication licensing proteins: Saints and sinners in cancer.

Semin Cancer Biol 2018 Nov 28. Epub 2018 Nov 28.

Cancer Centre, Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macau. Electronic address:

DNA replication is all-or-none process in the cell, meaning, once the DNA replication begins it proceeds to completion. Hence, to achieve maximum control of DNA replication, eukaryotic cells employ a multi-subunit initiator protein complex known as "pre-replication complex or DNA replication licensing complex (DNA replication LC). This complex involves multiple proteins which are origin-recognition complex family proteins, cell division cycle-6, chromatin licensing and DNA replication factor 1, and minichromosome maintenance family proteins. Read More

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November 2018
5 Reads

Neoadjuvant vs. Adjuvant Chemotherapy in Muscle Invasive Bladder Cancer (MIBC): Analysis From the RISC Database.

Front Oncol 2018 19;8:463. Epub 2018 Nov 19.

San Camillo-Forlanini Hospital, Rome, Italy.

MIBC is an aggressive disease, with 5-year survival rates ranging from 36 to 48% for p T3/p T4/p N+tumors. Perioperative treatment can improve overall survival, with more robust evidence in favor of neoadjuvant chemotherapy. Few randomized studies have compared neoadjuvant and adjuvant therapy in bladder cancer. Read More

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November 2018
1 Read

A delay ≥8 weeks to neoadjuvant chemotherapy before radical cystectomy increases the risk of upstaging.

Urol Oncol 2018 Nov 30. Epub 2018 Nov 30.

Division of Urology, VA Long Beach Healthcare System, Long Beach, CA; Department of Urology, University of California, Irvine, Orange, CA. Electronic address:

Objectives: To investigate delays to neoadjuvant chemotherapy (NAC) and radical cystectomy (RC) and their effect on outcomes in a large national registry of patients with localized muscle invasive bladder cancer.

Patients And Methods: Within the National Cancer Database (2004-2014), we identified 2,227 patients who underwent NAC and RC for cT2-T4aN0M0 urothelial carcinoma of the bladder. Times from diagnosis to treatments were tested for association with overall survival and pathologic outcomes, using Cox models, and restricted cubic splines regression. Read More

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November 2018
1 Read
2.768 Impact Factor

Keratinizing squamous metaplasia of the bladder: Our experience and current approaches.

Urologia 2018 Dec 3:391560318810197. Epub 2018 Dec 3.

2 Pathology Unit, ASST-Rhodense, Milan, Italy.

Introduction:: Bladder mucosa is anatomically covered by urothelial epithelium. The replacement of the urothelium with stratified squamous cells is defined as squamous metaplasia which can be keratinizing or non-keratinizing. Clinically, it is also known as leukoplakia or keratinizing cystitis of the bladder. Read More

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December 2018
1 Read

Morphological and Immunohistochemical Biomarkers in Distinguishing Prostate Carcinoma and Urothelial Carcinoma: A Comprehensive Review.

Int J Surg Pathol 2018 Dec 3:1066896918814198. Epub 2018 Dec 3.

1 University Hospital, Foggia, Italy.

The differential diagnosis between high-grade prostate carcinoma and infiltrating urothelial carcinoma (UC) in transurethral resection prostate specimens as well as cystoprostatectomy specimens may often be challenging due to morphologic and clinical overlap of the 2 entities. Such distinction has critical therapeutic and staging consequences, yet it is hampered by both issues in morphology and by the low accuracy rates of single immunohistochemical markers, as reported in literature. This review aims to provide a comprehensive analysis of the available morphological and immunohistochemical parameters, which may allow to discriminate between prostate carcinoma and urothelial carcinoma in the proper clinical context and to discuss their diagnostic applications in daily practice. Read More

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December 2018
1 Read

The prognostic significance of androgen receptor and β-catenin immunohistochemical expression in urothelial carcinoma with and without detrusor muscle invasion from an Egyptian institution.

Pol J Pathol 2018 ;69(3):234-242

Androgen receptor (AR) activation plays an important role in the promotion and progression of urothelial tumorigenesis. Also, dysregulation of the Wnt/β-catenin signaling pathway has also been linked to bladder cancer growth. However, cross talk between the two pathways in remains unclear in bladder cancer. Read More

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January 2018
1 Read

Potential role of the 3-mercaptopyruvate sulfurtransferase (3-MST)-hydrogen sulfide (HS) pathway in cancer cells.

Pharmacol Res 2018 Nov 27. Epub 2018 Nov 27.

Chair of Pharmacology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland. Electronic address:

Hydrogen sulfide (HS), produced by various endogenous enzyme systems, serves various biological regulatory roles in mammalian cells in health and disease. Over recent years, a new concept emerged in the field of HS biology, showing that various cancer cells upregulate their endogenous HS production, and utilize this mediator in autocrine and paracrine manner to stimulate proliferation, bioenergetics and tumor angiogenesis. Initial work identified cystathionine-beta-synthase (CBS) in many tumor cells as the key source of HS. Read More

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November 2018
1 Read

Management of Patients with renal mass lesions based on renal biopsy cytology results.

Hum Pathol 2018 Nov 27. Epub 2018 Nov 27.

Northwestern University, Chicago, IL. Electronic address:

The benefit of renal biopsy, especially in patients with a history of malignancy (HOM), has not been well-studied. We studied the clinical management of 339 renal masses following fine needle aspirate (FNA) and/or core needle biopsy (CNB) with touch preparation. 41% of patients had HOM, which did not increase the incidence of renal malignancy. Read More

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November 2018
2 Reads

Fluorescence in situ hybridization in 1 mL of selective urine for the detection of upper tract urothelial carcinoma: a feasibility study.

Med Oncol 2018 Nov 29;36(1):10. Epub 2018 Nov 29.

Department of Urology, Amsterdam University Medical Centers, University of Amsterdam, Meibergdreef 9 G4-223, 1105AZ, Amsterdam, The Netherlands.

Kidney-sparing surgery of upper tract urothelial carcinoma (UTUC) requires a stringent follow-up with frequent ureteroscopies. Triage testing could reduce the number of follow-up ureteroscopies and hence minimize the invasiveness of follow-up. The use of urine-based markers for triage seems appealing but should be feasible with selective urine from outpatient cystoscopy to maximize the reduction of invasiveness. Read More

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November 2018
1 Read

Long noncoding RNA UCA1 promotes the proliferation, invasion, and migration of nasopharyngeal carcinoma cells via modulation of miR-145.

Onco Targets Ther 2018 25;11:7483-7492. Epub 2018 Oct 25.

Department of Radiotherapy, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu, China,

Background: Nasopharyngeal carcinoma (NPC) is a common malignant tumor characterized by highly malignant local invasion and distant metastasis. Recently, increasing attention has been paid to long noncoding RNAs (lncRNAs), which play significant roles in tumorigenesis and progression. However, little is known about the potential role of the lncRNA urothelial carcinoma-associated 1 (UCA1) in NPC cell invasion and migration. Read More

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October 2018
1.342 Impact Factor

PD-L1 Antibody Comparison in Urothelial Carcinoma.

Eur Urol 2018 Nov 26. Epub 2018 Nov 26.

Department of Pathology, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The Netherlands.

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November 2018
4 Reads

Orbital Metastasis From Urothelial Carcinoma: A Comprehensive Literature Review.

Ophthalmic Plast Reconstr Surg 2018 Nov 21. Epub 2018 Nov 21.

Department of Ophthalmology, Byers Eye Institute, Stanford School of Medicine, Palo Alto, California, U.S.A.

Purpose: To review the clinical features of orbital and choroidal metastases from urothelial carcinomas of the urinary tract among cases reported in the literature, and to describe a case of orbital metastasis from bladder cancer presenting as apparent internuclear ophthalmoplegia.

Methods: Case reports of orbital and choroidal metastases from urothelial carcinomas published in the literature from 1965 to 2018 were reviewed. Data collected included patient demographics, cancer stage and primary site, time to onset of ocular symptoms, length of presenting ocular symptoms, types of primary ocular symptoms, diagnostic imaging, histology, systemic and ocular treatments, and survival time. Read More

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November 2018
2 Reads

Prime time for immunotherapy in advanced urothelial cancer.

Asia Pac J Clin Oncol 2018 Nov;14 Suppl 5:24-32

Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario.

Background: Metastatic urothelial cancer (UC) is a lethal disease. Until 2016, cytotoxic chemotherapy with substantial toxicity was the only therapeutic option. In the first-line metastatic setting, cisplatin-based combination chemotherapy remains the standard of care. Read More

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November 2018
1 Read

Validation of the preoperative controlling nutritional status score as an independent predictor in a large Chinese cohort of patients with upper tract urothelial carcinoma.

Cancer Med 2018 Nov 28. Epub 2018 Nov 28.

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.

Background: Pretreatment controlling nutritional status (CONUT) score is a novel index which was used to predict outcomes in cancer patients. We aim to explore the prognostic significance of CONUT score in patients with upper tract urothelial carcinoma (UTUC) after radical nephroureterectomy (RNU).

Patients And Methods: A total of 662 UTUC patients between 2004 and 2016 were retrospectively analyzed. Read More

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November 2018
1 Read

Analysis of the prognostic relevance of sex-steroid hormonal receptor mRNA expression in muscle-invasive urothelial carcinoma of the urinary bladder.

Virchows Arch 2018 Nov 27. Epub 2018 Nov 27.

Department of Urology and Pediatric Urology, University of Ulm, Ulm, Germany.

Muscle-invasive urothelial carcinoma of the urinary bladder (UCB) often recurs following radical cystectomy (RC). An altered expression of sex-steroid hormone receptors has been associated with oncological outcomes of UCB and may represent therapeutic targets. Here the expression of different hormone receptors was measured on mRNA levels in patients treated by RC and associated with outcomes. Read More

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November 2018
3 Reads

Comparative Effectiveness of Bladder-preserving Tri-modality Therapy Versus Radical Cystectomy for Muscle-invasive Bladder Cancer.

Clin Genitourin Cancer 2018 Oct 4. Epub 2018 Oct 4.

Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA. Electronic address:

Introduction: There are limited randomized data comparing radical cystectomy (RC) with bladder-sparing tri-modality therapy (TMT) in the treatment of muscle-invasive bladder cancer (MIBC). Both strategies are thought to have similar survival outcomes with different morbidity profiles. We compare the effectiveness of TMT and RC using decision-analytic modeling and the endpoint of quality-adjusted life years (QALYs). Read More

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October 2018
1 Read

Extracorporeal shockwave against inflammation mediated by GPR120 receptor in cyclophosphamide-induced rat cystitis model.

Mol Med 2018 Nov 27;24(1):60. Epub 2018 Nov 27.

Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, 83301, Taiwan.

Background: We tested the hypothesis that extracorporeal shockwave treatment (ESWT) can abolish inflammation and restore urothelial barrier integrity in acute interstitial cystitis by upregulating the fatty acid receptor GPR120.

Methods: A total of 30 female Sprague-Dawley rats were categorized into five groups: (1) sham-operated rats (SC); (2) rats treated with ESWT (SC + ESWT); (3) rats with bladder irritation using 150 mg/kg cyclophosphamide through intraperitoneal injection; (4) cyclophosphamide rats treated with ESWT (cyclophosphamide+ESWT); (5) cyclophosphamide rats treated with GPR120 agonist (cyclophosphamide+GW9508).

Results: On Day 3, urine and bladder specimens were collected for biochemical, histopathological, immunological, and immunoblotting analysis. Read More

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November 2018
1 Read
4.508 Impact Factor

Long Non-Coding RNA Urothelial Carcinoma Associated 1 Promotes Proliferation, Migration and Invasion of Osteosarcoma Cells by Regulating microRNA-182.

Cell Physiol Biochem 2018 27;51(3):1149-1163. Epub 2018 Nov 27.

Department of Hand Surgery, China-Japan Union Hospital of Jilin University, Changchun,

Background/aims: Previous studies demonstrated the oncogenic roles of lncRNA UCA1 in osteosarcoma. This study aimed to explore the internal molecular mechanism of UCA1 on promoting osteosarcoma cell proliferation, migration and invasion.

Methods: qRT-PCR was conducted to measure the expression levels of UCA1, miR-182 and TIMP2. Read More

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November 2018
2 Reads

Product review: avelumab, an anti-PD-L1 antibody.

Hum Vaccin Immunother 2018 Nov 27. Epub 2018 Nov 27.

a Medical Oncology Service, Center for Cancer Research , National Cancer Institute, National Institutes of Health , Bethesda , MD , USA.

Although immunotherapies have been employed for many decades, immune checkpoint inhibitors have only recently entered the oncologic landscape. Avelumab is a fully human monoclonal antibody that blocks the interaction between PD-L1 on tumor cells and PD-1 on T cells, thereby inhibiting immunosuppression in the tumor microenvironment and reducing tumor growth. Most early clinical trials of avelumab as monotherapy and in combination regimens were part of the international JAVELIN clinical trial program, which included more than 7000 patients in more than 30 trials with at least 15 tumor types. Read More

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November 2018
2 Reads

Prognostic significance of serum γ-glutamyltransferase in patients with advanced urothelial carcinoma.

Urol Oncol 2018 Nov 24. Epub 2018 Nov 24.

Department of Urology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan. Electronic address:

Objectives: Serum γ-glutamyltransferase (GGT) is reportedly associated with prognosis in patients with various malignancies. However, the prognostic role of GGT is unknown among patients with advanced urothelial carcinoma (aUC). This study was designed to examine the prognostic role of serum GGT in patients with aUC. Read More

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November 2018
3 Reads

Compensatory regrowth of the mouse bladder after partial cystectomy.

PLoS One 2018 26;13(11):e0206436. Epub 2018 Nov 26.

Developmental Biology, Stanley Manne Children's Research Institute, Anne and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, United States of America.

Cystectomy is the removal of all or part of the urinary bladder. It has been observed that there is significant regrowth of the bladder after partial cystectomy and this has been proposed to be through regeneration of the organ. Regrowth of tissue in mammals has been proposed to involve compensatory mechanisms that share many characteristics of true regeneration, like the growth of specialized structures such as blood vessels or nerves. Read More

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November 2018
2 Reads

TROY expression is associated with pathological stage and poor prognosis in patients treated with radical cystectomy.

Cancer Biomark 2018 Nov 10. Epub 2018 Nov 10.

Department of Urology, School of Medicine, Kitasato University, Sagamihara 2520374, Japan.

Background: New biomarkers may help us provide individualized prognosis and allow risk-stratified clinical decision making about radical treatment.

Objectives: This study aimed to determine the tumor necrosis factor of receptor superfamily 19 (TROY) expression in urothelial carcinoma and its relationship to clinicopathological findings.

Methods: Immunohistochemical staining for TROY was carried out in 136 archival radical cystectomy specimens with immunoreactivity being stratified on a 0-9 scale. Read More

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November 2018
1 Read

Patterns of Urachal Remnant Involvement by Urothelial Carcinoma: Intraluminal Noninvasive Spread can Mimic a Deep-seated Bladder Invasion.

Am J Surg Pathol 2018 Nov 20. Epub 2018 Nov 20.

Departments of Pathology.

Benign urachal remnants can be encountered in the adult urinary bladder and it is recognized that these can uncommonly give rise to urachal urothelial carcinoma. However, urachal remnants containing urothelial carcinoma incidentally encountered in cystectomies for bladder cancer has not been previously described. Herein, we present 8 adult bladder cancer cystectomies with incidental urachal remnants containing urothelial carcinoma. Read More

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November 2018
1 Read

Enterovesical Fistula Secondary to Transitional Cell Carcinoma of the Bladder.

Surg J (N Y) 2018 Oct 18;4(4):e201-e204. Epub 2018 Oct 18.

Department of Urology, Mater Dei Hospital, Msida, Malta.

Although fistulae between the urinary bladder and the gastrointestinal tract are not uncommon, those caused by carcinoma of the urinary bladder are rare. This report describes the case of an 85 years old male who was diagnosed with a mass involving the small bowel and the urinary bladder during the course of investigation for recurrent urinary tract infections. At laparotomy, the presence of an enterovesical fistula involving the ileum and bladder was confirmed. Read More

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October 2018
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