275 results match your criteria Urothelial Papilloma of the Urinary Bladder


Urothelial Papilloma of the Urinary Bladder in Children: Report of Two Cases.

European J Pediatr Surg Rep 2020 Jan 23;8(1):e23-e26. Epub 2020 Apr 23.

Department of Pediatrics, University of Pecs, Pecs, Hungary.

Urothelial neoplasms of the bladder (UNB) are considerably rare throughout the pediatric population. UNB develops from the urothelial tissue in the form of a benign disease, generally favoring a successful prognosis in the majority of cases. The authors present the diagnosis and treatment regarding two medical case reports in which urothelial papilloma was diagnosed and effectively treated. Read More

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http://dx.doi.org/10.1055/s-0040-1705154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7180073PMC
January 2020

Inverted papilloma of the urinary bladder shows fluorescence on photodynamic diagnosis using 5-aminolevulinic acid.

Photodiagnosis Photodyn Ther 2020 Jun 18;30:101766. Epub 2020 Apr 18.

Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Photodynamic diagnosis (PDD) of non-muscle invasive bladder cancer using 5-aminolevulinic acid (5-ALA) has recently attracted attention as a diagnostic method for observing cancer lesions based on fluorescence emission using a fluorescent endoscope. However, there are few reports of false positives associated with benign bladder neoplasms. Here, we provide report of two cases of inverted papillomas of the bladder that were fluorescent on PDD using 5-ALA. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101766DOI Listing

Glandular-type inverted papilloma of urinary bladder - Report of a unique case with immunohistochemistry.

Indian J Pathol Microbiol 2020 Jan-Mar;63(1):96-97

Department of Urology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Inverted papilloma of urothelium is a rare benign tumour accounting for 1-2% of all the urothelial lesions. Morphologically, these are of two main subtypes - trabecular and glandular, of which the former subtype is most frequently encountered compared to the latter. The glandular subtype closely mimics cystitis glandularis and urothelial carcinoma with inverted growth pattern. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_456_18DOI Listing
February 2020

[Inverted Variant of Urothelial Carcinoma of the Urinary Bladder : A Case Report].

Hinyokika Kiyo 2019 Nov;65(11):463-467

The Department of Molecular Pathology, Shinshu University School of Medicine.

A 69-year-old male complained of gross hematuria. Cystoscopy revealed a papillary pedunculated tumor. The tumor was approximately 4 cm in length, and mimicked an inverted papilloma with a small stalk and smooth surface, located on the bladder trigone. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_65_11_463DOI Listing
November 2019

Evaluation of platelet distribution width as a diagnostic and prognostic biomarker in bladder neoplasm.

Future Oncol 2019 Nov 18;15(33):3797-3807. Epub 2019 Sep 18.

Department of Urology, Qilu Hospital of Shandong University, Jinan, China.

To evaluate the role of preoperative platelet distribution width (PDW) as a potential biomarker for distinguishing malignancy and tumor advantage of bladder neoplasm. The study included 210 subjects with bladder cancer, 76 subjects with urothelial papilloma and 132 healthy control subjects. Preoperative PDW along with other blood indices was evaluated. Read More

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http://dx.doi.org/10.2217/fon-2019-0441DOI Listing
November 2019
2.477 Impact Factor

Proteomic characterization of arsenic and cadmium exposure in bladder cells.

Rapid Commun Mass Spectrom 2020 Apr 8;34 Suppl 1:e8578. Epub 2020 Feb 8.

Molecular Medicine Research Center, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Rationale: Accumulating evidence has linked prolonged exposure to heavy metals to cancer occurrence in the urinary system. However, the specific biological mechanisms responsible for the association of heavy metals with the unusually high incidence of upper tract urothelial carcinoma in Taiwan are complex and incompletely understood.

Methods: To elucidate the specific biological mechanism and identify molecular indicators of the unusually high association of upper tract urothelial carcinoma with heavy metal exposure, protein expression following the treatment of T24 human bladder carcinoma and RT4 human bladder papilloma cell line models with arsenic (As) and cadmium (Cd) was studied. Read More

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http://dx.doi.org/10.1002/rcm.8578DOI Listing
April 2020
2 Reads

Invasive high-grade urothelial carcinoma of the bladder, renal pelvis, ureter, and prostatic urethra arising in a background of urothelial carcinoma with an inverted growth pattern: a contemporary clinicopathological analysis of 91 cases.

Hum Pathol 2019 10 24;92:18-24. Epub 2019 Jul 24.

Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322; Department of Urology, Emory University School of Medicine, Atlanta, GA 30322; Department of Pathology, Veterans Affairs Medical Center, Decatur, GA 30033; Winship Cancer Institute of Emory University, Atlanta, GA 30322. Electronic address:

Urothelial carcinoma with an inverted/endophytic growth pattern can occasionally mimic inverted urothelial papilloma and pose diagnostic challenges when assessing the presence or absence of invasion. Making these distinctions is critical for guiding appropriate treatment and improving patient outcomes. Here we conducted one of the largest studies to date of invasive high-grade urothelial carcinoma arising in a background of urothelial carcinoma with an inverted growth pattern. Read More

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http://dx.doi.org/10.1016/j.humpath.2019.07.005DOI Listing
October 2019

Distinct mutational landscape of inverted urothelial papilloma.

J Pathol 2019 09 2;249(1):3-5. Epub 2019 Jul 2.

Department of Pathology, Indiana University School of Medicine, Indianapolis, IN, USA.

A recent study has identified gene mutations involving the MAPK/ERK pathway, particularly the HRAS gene, in all inverted urothelial papillomas (IUPs), in the absence of pathway mutations in TERT promoter, FGFR3, and TP53/RB1genes. Neither recurrence nor progression was observed in IUPs. These data support several longstanding hypotheses: (1) IUPs are benign and do not recur or progress; (2) they harbor mutations that are different from those of urothelial carcinoma; and (3) they arise through different molecular mechanisms than low- or high-grade urothelial carcinoma. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/path.5307
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http://dx.doi.org/10.1002/path.5307DOI Listing
September 2019
30 Reads

Genomic landscape of inverted urothelial papilloma and urothelial papilloma of the bladder.

J Pathol 2019 07 22;248(3):260-265. Epub 2019 Apr 22.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Inverted urothelial papilloma (IUP) and urothelial papilloma (UP) are rare urothelial neoplasms that typically follow a benign clinical course. Oncogenic mutations in FGFR3, HRAS, and the TERT promoter have been reported in these entities but no comprehensive molecular analysis has been performed. We sought to characterize the genomic landscape of IUP and UP using whole-exome and targeted next-generation sequencing. Read More

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http://doi.wiley.com/10.1002/path.5261
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http://dx.doi.org/10.1002/path.5261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6579631PMC
July 2019
26 Reads

Expression pattern of p53-binding protein 1 as a new molecular indicator of genomic instability in bladder urothelial carcinoma.

Sci Rep 2018 10 19;8(1):15477. Epub 2018 Oct 19.

Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.

Copy number alterations and loss of heterozygosity are associated with increasing tumor grade and bladder cancer stage. Our previous study suggested that co-expression of Ki-67 and p53-binding protein 1 (53BP1) could provide an indicator of an abnormal DNA damage response (DDR) pathway. The present study investigated 53BP1 expression as a novel molecular marker in urothelial carcinoma (UC) using bladder tissues with in total of 40 cases including a normal urothelium, urothelial papilloma, low-grade UC, or high-grade UC. Read More

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http://www.nature.com/articles/s41598-018-33761-9
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http://dx.doi.org/10.1038/s41598-018-33761-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195620PMC
October 2018
12 Reads

Diagnostic Value of Glucose Transporter 1 (GLUT-1) Expression in Nested Variant of Urothelial Carcinoma.

Turk Patoloji Derg 2019 ;35(1):22-27

Department of Pathology, 1Sultanbeyli State Hospital, ISTANBUL, TURKEY.

Objective: Nested variant is bland-looking but aggressive subtype of urothelial carcinoma (UC). Cases having significant muscle invasion do not cause problems but small and superficial biopsies may be challenging due to morphological similarities between nested variant urothelial carcinoma and benign urothelial lesions.

Material And Method: We studied Glucose transporter 1 (GLUT-1), which is an integral membrane protein providing glucose pass through plasma membrane down its concentration gradient, to see if it is useful for the differential diagnosis. Read More

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http://www.turkjpath.org/doi.php?doi=10.5146/tjpath.2018.014
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http://dx.doi.org/10.5146/tjpath.2018.01435DOI Listing
August 2019
4 Reads

Urothelial carcinoma in children: A case series.

Bull Cancer 2018 Jun 1;105(6):556-561. Epub 2018 May 1.

Ospedale dei Bambini V. Buzzi, Pediatric Surgery Department, Via Castelvetro 32, 20154 Milano, Italy.

Objective: To report a series of 5 patients with urothelial bladder cancer (UBC) three of them with a history of exposure to amines and only two with gross hematuria.

Materials And Methods: After obtaining ethical and legal authorization, we performed a restrospective monocentric study. We collected information of patients with UBC over a period of 10 years. Read More

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http://dx.doi.org/10.1016/j.bulcan.2018.03.002DOI Listing
June 2018
12 Reads

Diagnostic difficulties in cases of papillary urothelial neoplasm of low malignant potential, urothelial proliferation of uncertain malignant potential, urothelial dysplasia and urothelial papilloma: A review of current literature.

Ann Diagn Pathol 2019 Jun 17;40:182-188. Epub 2017 Dec 17.

Department of Oncologic Pathology and Prophylactics, Poznan University of Medical Sciences, Department of Oncologic Pathology, Greater Poland Cancer Center, Poland.

Tumours of the urinary tract are the fifth most frequent type of cancer. The most common types are urothelial tumours, among which, non-invasive urothelial neoplasms represent 45% of all cases. The 2016 WHO classification of urinary tract tumours introduced new classifications of non-invasive lesions. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2017.12.007DOI Listing
June 2019
32 Reads

Urothelial neoplasms in pediatric and young adult patients: A large single-center series.

J Pediatr Surg 2018 Feb 14;53(2):306-309. Epub 2017 Nov 14.

Pediatric Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:

Purpose: Bladder cancer is the sixth most common cancer in the United States, but is exceedingly rare in young patients, leading to a lack of accepted standards for diagnosis, treatment, and surveillance. We review our institutional experience with bladder urothelial neoplasms in pediatric and young adult patients summarizing presentation, treatment, and outcomes.

Methods: Surgical pathology records at our institution were searched for cases of urothelial neoplasms among patients ≤25 years of age treated between January 1997 and September 2016. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2017.11.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828877PMC
February 2018
45 Reads

Biological significance of TERT promoter mutation in papillary urothelial neoplasm of low malignant potential.

Histopathology 2018 Apr 4;72(5):795-803. Epub 2018 Jan 4.

Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan.

Aims: Mutations in FGFR3 and the promoter region of the telomerase reverse transcriptase (TERT) gene have been found frequently in urothelial carcinoma of the urinary bladder. However, related data for papillary urothelial neoplasm of low malignant potential (PUNLMP) are limited. In this study, we investigated the mutation status of the TERT promoter, FGFR3 and HRAS in low-grade papillary urothelial neoplasms and evaluated their prognostic significance. Read More

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http://dx.doi.org/10.1111/his.13441DOI Listing
April 2018
24 Reads

Urothelial papilloma: a rare cause of gross haematuria in childhood.

BMJ Case Rep 2017 May 13;2017. Epub 2017 May 13.

Department of Paediatrics, Hospital Center of Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal.

Bladder urothelial papilloma is extremely rare in the paediatric population. It usually presents as painless gross haematuria and its diagnosis implies a high index of suspicion as other causes of haematuria predominate in this age range. We describe a 9-year-old boy with two episodes of gross haematuria occurring 1 year apart with spontaneous resolution after 2 days. Read More

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http://dx.doi.org/10.1136/bcr-2017-219341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5612437PMC
May 2017
29 Reads

[Vesical urothelial papilloma].

Cir Pediatr 2016 Jul 10;29(3):131-133. Epub 2016 Jul 10.

Servicio de Cirugía Pediátrica. Hospital Universitario Materno-Infantil. Badajoz.

Introduction: Vesical tumors of infancy are of a low incidence and isolated clinical cases exist, and therefore there are no protocols regarding treatment and monitoring. In addition, the histological criteria used until now are the ones in the WHO 2004 guidelines.

Clinical Case: A 11 year old boy with non-specific abdominal pain. Read More

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July 2016
27 Reads

Horseradish extract promotes urinary bladder carcinogenesis when administered to F344 rats in drinking water.

J Appl Toxicol 2017 07 6;37(7):853-862. Epub 2017 Feb 6.

Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-Ku, Tokyo, 158-8501, Japan.

Horseradish extract (HRE), consisting mainly of a mixture of allyl isothiocyanate and other isothiocyanates, has been used as a food additive. To evaluate the potential hazards of HRE, a 104-week chronic study, a 2-week analysis of cell proliferation in the urinary bladder and a medium-term promotion bioassay of HRE were conducted with administration at concentrations of up to 0.04% HRE in the drinking water to male F344 rats. Read More

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http://dx.doi.org/10.1002/jat.3434DOI Listing
July 2017
51 Reads

TERT Promoter Mutations Occur Frequently in Urothelial Papilloma and Papillary Urothelial Neoplasm of Low Malignant Potential.

Eur Urol 2017 03 28;71(3):497-498. Epub 2016 Dec 28.

Unit of Anatomical Pathology, Faculty of Medicine, Cordoba, Spain; Champalimaud Clinical Center, Lisbon, Portugal.

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http://dx.doi.org/10.1016/j.eururo.2016.12.008DOI Listing
March 2017
12 Reads

Elevated preoperative plasma fibrinogen level is an independent predictor of malignancy and advanced stage disease in patients with bladder urothelial tumors.

Int J Surg 2016 Dec 5;36(Pt A):249-254. Epub 2016 Nov 5.

Department of Urology, Jinshan Hospital of Fudan University, Shanghai City, 201508, PR China. Electronic address:

Purpose: To investigate the association between preoperative plasma fibrinogen levels and clinicopathological features in patients with bladder urothelial tumors.

Methods: In this retrospective single-center study, we evaluated preoperative plasma fibrinogen levels in 503 patients newly diagnosed with bladder urothelial tumors between January 2009 and October 2014. All patients received surgical intervention as the primary treatment method. Read More

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http://dx.doi.org/10.1016/j.ijsu.2016.11.010DOI Listing
December 2016
50 Reads

Inverted Papilloma of the Bladder Coexisting with Urothelial Carcinoma. A Case Report.

Anal Quant Cytopathol Histpathol 2016 Feb;38(1):52-6

Background: Inverted papilloma (IP) is an unusual benign neoplasm, most commonly found in the bladder. Cases of malignant transformation have been reported in the past, although most of them are now considered to be urothelial carcinomas with an inverted growth pattern.

Case: A 54-year-old man was diagnosed with urothelial carcinoma in situ (UCIS), high-grade papillary urothelial carcinoma (HGPUC), and IP by transurethral resection specimen of the bladder. Read More

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February 2016
53 Reads

Loss of Cell Differentiation in HPV-Associated Bladder Cancer.

Bull Exp Biol Med 2016 May 6;161(1):96-8. Epub 2016 Jun 6.

N. N. Blokhin Russian Cancer Research Center, Moscow, Russia.

Medical histories of 101 urothelial bladder cancer patients were compared with the results of morphological analysis and biomolecular detection of human papilloma viruses (HPV) in the tumor specimens. DNA of HPV16 (the major type of virus responsible for appearance of cervical carcinoma) was detected in 38 specimens, while mRNA of E6 and E7 oncogenes and E7 oncoprotein of HPV16 were observed in 13 specimens. HPV-positive bladder cancer was characterized by higher degree of cell anaplasia than HPV-negative cancer; in the primary bladder tumor, HPV was detected more often than in recurrent bladder cancer. Read More

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http://dx.doi.org/10.1007/s10517-016-3354-xDOI Listing
May 2016
15 Reads

Urothelial neoplasm of the bladder in childhood and adolescence: a rare disease.

Int Braz J Urol 2016 Mar-Apr;42(2):242-6

Dicle University, Faculty of Medicine, Department of Medical Pathology, Diyarbakir, Turkey.

Purpose: Bladder tumors are rare in children and adolescents. For this reason, the diagnosis is sometimes delayed in pediatric patients. We aimed to describe the diagnosis, treatment, and follow-up methods of bladder urothelial neoplasms in children and adolescents. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871383PMC
http://dx.doi.org/10.1590/S1677-5538.IBJU.2015.0200DOI Listing
March 2017
16 Reads

Immunohistochemical Differentiation between Urothelial Papillomas and Papillary Neoplasms of Low Malignant Potential of the Urinary Bladder.

Asian Pac J Cancer Prev 2016 ;17(4):1769-72

Department of Pathology, Faculty of Medicine, University of Tanta, Tanta, Egypt E-mail :

Background: Urothelial papilloma and non-invasive papillary carcinoma are common neoplasms of the urinary bladder. Distinguishing papillomas and papillary carcinomas, especially the low grade type, is often debatable on the basis of histological features alone.

Materials And Methods: We investigated immunohistochemical expression of cytokeratin 20 (CK20), p53, and Ki-67 in a group of 20 urothelial papilloma cases and 30 noninvasive papillary neoplasms of low malignant potential (PNLMP) of the urinary bladder. Read More

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http://dx.doi.org/10.7314/apjcp.2016.17.4.1769DOI Listing
January 2017
26 Reads

The pathology of urinary bladder lesions with an inverted growth pattern.

Chin J Cancer Res 2016 Feb;28(1):107-21

1 Department of Pathology, Chinese PLA General Hospital, Beijing 100853, China ; 2 Department of Pathology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310058, China.

Inverted lesions in the urinary bladder have been the source of some difficulty in urological pathology. The two common ones are von Brunn's nests and cystitis cystic/cystitis glandularis, which are considered normal variants of urothelium. Apart from them, a number of other rare urothelial lesions with inverted growth pattern occur in the urinary bladder. Read More

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http://dx.doi.org/10.3978/j.issn.1000-9604.2016.02.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779755PMC
February 2016
95 Reads

Recurrent TERT promoter mutations in urothelial carcinoma and potential clinical applications.

Ann Diagn Pathol 2016 Apr 17;21:7-11. Epub 2015 Dec 17.

Department of Pathology, Westchester Medical Center/New York Medical College, Valhalla, NY; Department of Pathology, Mount Sinai Medical Center, New York, NY. Electronic address:

Increased telomerase activity is associated with almost all types of advanced human cancers with unknown molecular mechanism(s). Two recurrent point mutations in the promoter region of telomerase reverse transcriptase (TERT)--the key subunit of telomerase--have recently been identified in melanoma as well as a small sample of bladder cancer cell lines. However, the incidence and clinical-pathological significance of these mutations in urothelial carcinoma have not been well established yet. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10929134150015
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http://dx.doi.org/10.1016/j.anndiagpath.2015.12.002DOI Listing
April 2016
47 Reads

Telomerase reverse transcriptase (TERT) promoter mutation analysis of benign, malignant and reactive urothelial lesions reveals a subpopulation of inverted papilloma with immortalizing genetic change.

Histopathology 2016 Jul 11;69(1):107-13. Epub 2016 Feb 11.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

Aims: To understand more clearly the genetic ontogeny of inverted papilloma of urinary bladder, we analysed telomerase reverse transcriptase (TERT) promoter mutation status in a group of 26 inverted papillomas in comparison with the mutation status of urothelial carcinoma with inverted growth (26 cases), conventional urothelial carcinoma (36 Ta non-invasive urothelial carcinoma, 35 T2 invasive urothelial carcinoma) and cystitis glandularis (25 cases).

Methods And Results: TERT promoter mutations in inverted papilloma, urothelial carcinoma with inverted growth, urothelial carcinoma and cystitis glandularis were found in 15% (four of 26), 58% (15 of 26), 63% (45 of 71) and 0% (none of 25), respectively. C228T mutations were the predominant mutations (97%) found in bladder tumours, while C250T aberrations occurred in approximately 3% of bladder tumours. Read More

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http://dx.doi.org/10.1111/his.12920DOI Listing
July 2016
75 Reads

Altered expression of CKs 14/20 is an early event in a rat model of multistep bladder carcinogenesis.

Int J Exp Pathol 2015 Oct 30;96(5):319-25. Epub 2015 Oct 30.

Grupo de Patologia e Terapêutica Experimental, CI-IPOP, Instituto Português de Oncologia, Porto, Portugal.

Cytokeratins (CKs) 14 and 20 are promising markers for diagnosing urothelial lesions and for studying their prognosis and histogenesis. This work aimed to study the immunohistochemical staining patterns of CK14/20 during multistep carcinogenesis leading to papillary bladder cancer in a rat model. Thirty female Fischer 344 rats were divided into three groups: group 1 (control); group 2, which received N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) for 20 weeks plus 1 week without treatment; and group 3, which received BBN for 20 weeks plus 8 weeks without treatment. Read More

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http://dx.doi.org/10.1111/iep.12145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4693561PMC
October 2015
41 Reads

Transurethral Resection of the Bladder Tumour as a Treatment Method in Children with Transitional Cell Carcinoma of the Bladder--Analysis of Our Material and Literature Review.

Adv Clin Exp Med 2015 May-Jun;24(3):505-9

Department of Palliative Care Nursing, Wroclaw Medical University, Poland; Department of Urology, 4th Military Clinical Hospital with Polyclinic, Wrocław, Poland.

Background: Bladder cancer occurs mainly in adults. In children, younger than 10 years in particular, it is very rare.

Objectives: The aim of the study is to retrospectively evaluate the efficacy of transurethral resection of the bladder tumour (TUR-BT) of transitional cell carcinoma (TCC) of the bladder in children. Read More

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http://dx.doi.org/10.17219/acem/36600DOI Listing
November 2015
41 Reads

A clinical and molecular review of inverted papilloma of the urinary tract: how to handle?

APMIS 2015 Nov 11;123(11):920-9. Epub 2015 Sep 11.

Department of Urology, Bispebjerg and Frederiksberg Hospitals, University of Copenhagen, Copenhagen, Denmark.

Inverted papilloma (IP) of the urinary tract is classified by the World Health Organisation as a non-invasive urothelial tumour with normal to minimal cytological atypia of the neoplastic cells. During the 1980s, it came under suspicion of having a premalignant or malignant potential and of being concurrent with urothelial cell carcinoma (UCC). This quandary has been proven difficult to solve, due to the fact that IP is very rare and literature mostly consists of case reports with varying levels of information, making strong meta-analyses problematic. Read More

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http://doi.wiley.com/10.1111/apm.12456
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http://dx.doi.org/10.1111/apm.12456DOI Listing
November 2015
68 Reads

Immunohistochemical Expression of Cyclin D1, Cytokeratin 20, and Uroplakin III in Proliferative Urinary Bladder Lesions Induced by o-Nitroanisole in Fischer 344/N Rats.

Vet Pathol 2016 May 28;53(3):682-90. Epub 2015 Aug 28.

Cellular and Molecular Pathology Branch, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA

o-Nitroanisole is an intermediate in the manufacture of azo dyes. In a National Toxicology Program stop-exposure study,o-nitroanisole induced hyperplasia, papillomas, and papillary carcinomas in the urinary bladder of Fischer 344/N rats.o-Nitroanisole was investigated since occupational or environmental exposure to aniline and azo dyes is a risk factor for urinary bladder cancer in humans. Read More

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http://journals.sagepub.com/doi/10.1177/0300985815603432
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http://dx.doi.org/10.1177/0300985815603432DOI Listing
May 2016
29 Reads

Inverted urothelial carcinoma: a series of 12 cases with a wide morphologic spectrum overlapping with the large nested variant.

Hum Pathol 2015 Oct 26;46(10):1506-13. Epub 2015 Jun 26.

Department of Pathology, Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec H4J1C5, Canada.

The current series presents 12 cases of invasive urothelial carcinoma (UC) with inverted growth pattern that fulfill the architectural criteria of the recently described "large nested" variant of UC, but which display a wider spectrum of morphologic and cytologic changes. All cases had an associated component of usual invasive UC, and 10 had an associated surface papillary component. Although many areas within the tumors were indistinguishable from a noninvasive endophytic growth pattern, at least some had an irregular ragged contour, and all showed haphazard arrangement with variable amount of intervening stroma at least focally. Read More

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http://dx.doi.org/10.1016/j.humpath.2015.06.010DOI Listing
October 2015
36 Reads

MRI Findings of Inverted Urothelial Papilloma of the Bladder.

AJR Am J Roentgenol 2015 Aug;205(2):311-6

1 Department of Radiology, Nagoya City University Graduate School of Medical Sciences and Medical School, 1 Kawasumi Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan.

Objective: The objective of this study was to characterize MRI findings of inverted urothelial papilloma of the bladder.

Materials And Methods: Data pertaining to 16 patients with 18 pathologically proven inverted urothelial papillomas of the bladder who had undergone MRI were retrospectively collected from seven institutions. The shape and surface characteristics of the tumors were evaluated using T2-weighted MR images. Read More

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http://dx.doi.org/10.2214/AJR.14.13879DOI Listing
August 2015
57 Reads

Long-term outcome of primary Papillary Urothelial Neoplasm of Low Malignant Potential (PUNLMP) including PUNLMP with inverted growth.

Diagn Pathol 2015 Mar 13;10. Epub 2015 Mar 13.

Department of Pathology and Laboratory Medicine, Calgary Laboratory Service and University of Calgary, Rockyview General Hospital, 7007 14 Street, Calgary, AB, Canada.

Background: Few larger studies have evaluated the long-term outcome after a diagnosis of papillary urothelial neoplasm of low malignant potential (PUNLMP), demonstrating a broad range of recurrence and progression rates. Additionally, no study has addressed the outcome of PUNLMP exhibiting inverted growth. We evaluated the long term clinical outcome of primary papillary urothelial neoplasm of low malignant potential (PUNLMP), including PUNLMP with inverted growth in a large single center study. Read More

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http://dx.doi.org/10.1186/s13000-015-0234-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415259PMC
March 2015
51 Reads
4 Citations
2.411 Impact Factor

OASIS/CREB3L1 is epigenetically silenced in human bladder cancer facilitating tumor cell spreading and migration in vitro.

Epigenetics 2014 Dec;9(12):1626-40

a Molecular Oncology Group; Institute of Pathology ; RWTH Aachen University ; Aachen , Germany.

CREB3L1 has been recently proposed as a novel metastasis suppressor gene in breast cancer. Our current study highlights CREB3L1 expression, regulation, and function in bladder cancer. We demonstrate a significant downregulation of CREB3L1 mRNA expression (n = 64) in primary bladder cancer tissues caused by tumor-specific CREB3L1 promoter hypermethylation (n = 51). Read More

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http://dx.doi.org/10.4161/15592294.2014.988052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623247PMC
December 2014
23 Reads

Urinary bladder xanthoma: a multi-institutional series of 17 cases.

Histopathology 2015 Aug 19;67(2):255-61. Epub 2015 Feb 19.

Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Calgary, AB, Canada.

Aims: To present a series of urinary bladder xanthomas and characterize their clinical features and associated pathology.

Methods And Results: We retrieved the clinicopathological data of bladder xanthomas, with and without associated urothelial neoplasms. We identified six isolated bladder xanthomas and 11 arising within or adjacent to urothelial neoplasms. Read More

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http://dx.doi.org/10.1111/his.12647DOI Listing
August 2015
48 Reads
1 Citation
3.453 Impact Factor

Bladder urothelial neoplasms in pediatric age: experience at three tertiary centers.

J Pediatr Urol 2015 Feb 28;11(1):26.e1-5. Epub 2014 Sep 28.

Department Nephrology-Urology, Division of Pediatric Urology, 'Bambino Gesù' Children's Hospital Rome, IRCCS, Piazza S. Onofrio, 4, 00165 Roma, Italy. Electronic address:

Introduction: Urothelial bladder neoplasms (UBN) typically occur in patients in their sixth or seventh decade of life while they are infrequent in children and young adults. They occur in 0.1-0. Read More

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http://dx.doi.org/10.1016/j.jpurol.2014.08.008DOI Listing
February 2015
59 Reads

Nested and microcystic variants of urothelial carcinoma displaying immunohistochemical features of basal-like urothelial cells: an immunohistochemical and histopathogenetic study.

Pathol Int 2014 Aug;64(8):375-81

Pathology and Laboratory Medicine, The Ottawa Hospital and University of Ottawa, Ottawa, Ontario, Canada.

Nested/microcystic (NV/MV) urothelial carcinoma (UC) variants are associated with mild cytologic atypia and commonly present at high-stage disease. The histopathogenesis is investigated using urothelial basal cell markers. Archival 14 NV/MV and three inverted papilloma (IP) were immunostained for CD44, cytokeratin 5 (CK5), CK34bE12 and p63. Read More

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http://dx.doi.org/10.1111/pin.12187DOI Listing
August 2014
25 Reads

Metastatic renal cell carcinoma to the urinary bladder: a report of 11 cases.

Am J Surg Pathol 2014 Nov;38(11):1516-21

*The Department of Pathology ‡Urology and Oncology, The Johns Hopkins Hospital, Baltimore, MD †Department of Pathology, Queen Elizabeth Hospital, Hong Kong, PR China.

Metastatic renal cell carcinoma (RCC) to the urinary bladder is rarely seen. Herein, we report the histologic subtypes, immunohistochemical characteristics, and prognosis of 11 patients with metastatic RCC to the urinary bladder. The mean age at the time of diagnosis of metastatic RCC to the bladder was 66 years (range, 58 to 79 y). Read More

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http://dx.doi.org/10.1097/PAS.0000000000000257DOI Listing
November 2014
36 Reads

HRAS mutations are frequent in inverted urothelial neoplasms.

Hum Pathol 2014 Sep 18;45(9):1957-65. Epub 2014 Jun 18.

Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:

Inverted urothelial papilloma (IUP) is an uncommon neoplasm of the urinary bladder with distinct morphologic features. Studies regarding the role of human papillomavirus (HPV) in the etiology of IUP have provided conflicting evidence of HPV infection. In addition, little is known regarding the molecular alterations present in IUP or other urothelial neoplasms, which might demonstrate inverted growth pattern like low-grade or high-grade urothelial carcinoma (UCA). Read More

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http://dx.doi.org/10.1016/j.humpath.2014.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241848PMC
September 2014
56 Reads

Molecular characteristics of urothelial neoplasms in children and young adults: a subset of tumors from young patients harbors chromosomal abnormalities but not FGFR3 or TP53 gene mutations.

Mod Pathol 2014 Nov 18;27(11):1540-8. Epub 2014 Apr 18.

1] Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA [2] Department of Urology, Indiana University School of Medicine, Indianapolis, IN, USA.

Urothelial neoplasms in children and young adult patients are rare and hypothesized to have a lower rate of recurrence and progression than those of older adults. Because of their rarity, data regarding molecular abnormalities in these tumors are limited. We studied molecular characteristics of urothelial neoplasms from patients under age 30 years using UroVysion fluorescence in situ hybridization (chromosomes 3, 7, 17, and 9p21) and DNA mutational analysis for the FGFR3 and TP53 genes. Read More

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http://www.nature.com/articles/modpathol201448
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http://dx.doi.org/10.1038/modpathol.2014.48DOI Listing
November 2014
41 Reads

Mammalian target of rapamycin complex 2 (mTORC2) is a critical determinant of bladder cancer invasion.

PLoS One 2013 27;8(11):e81081. Epub 2013 Nov 27.

Department of Pathology, University of California San Diego, La Jolla, California, United States of America.

Bladder cancer is the fourth most common cause of cancer in males in the United States. Invasive behavior is a major determinant of prognosis. In this study, we identified mammalian target of rapamycin complex 2 (mTORC2) as a central regulator of bladder cancer cell migration and invasion. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081081PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842329PMC
December 2014
25 Reads

Long term outcome of primary urothelial papilloma: a single institution cohort.

Pathology 2014 Jan;46(1):37-40

1Department of Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Calgary 2Division of Urology, University of Calgary, Calgary, Alberta, Canada.

The aim of this study was to investigate the long term outcome of primary urothelial papilloma (UP). We retrieved 41 primary UP, diagnosed between January 2000 and December 2009. Follow-up was obtained by searching pathology and clinical electronic databases. Read More

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http://dx.doi.org/10.1097/PAT.0000000000000029DOI Listing
January 2014
36 Reads
2.190 Impact Factor

Heterogeneity of uroplakin localization in human normal urothelium, papilloma and papillary carcinoma.

Radiol Oncol 2013 8;47(4):338-45. Epub 2013 Oct 8.

Institute of Cell Biology, Faculty of Medicine, Ljubljana, Slovenia.

Background: Uroplakins are differentiation-related membrane proteins of urothelium. We compared uroplakin expression and ultrastructural localization in human normal urothelium, papilloma and papillary carcinoma. Because of high recurrence rate of these tumours, treated by transurethral resection, we investigated urothelial tumour, resection border and uninvolved urothelium. Read More

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http://dx.doi.org/10.2478/raon-2013-0052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3814278PMC
December 2013
49 Reads

Long-term clinical outcome of inverted urothelial papilloma including cases with focal papillary pattern: is continuous surveillance necessary?

Urology 2013 Oct;82(4):857-60

Department of Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Calgary, Alberta, Canada.

Objective: To investigate the necessity for continuous cystoscopic surveillance of inverted papilloma (IP), including tumors exhibiting mixed morphology (IP with focal papillary architecture).

Methods: We retrieved all cases of de novo ("primary") IP, diagnosed in our institution during 10 years (from January 2000 to December 2009), from the information database. Patients with a history of urothelial carcinoma or concurrent urothelial carcinoma were excluded. Read More

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http://dx.doi.org/10.1016/j.urology.2013.06.040DOI Listing
October 2013
35 Reads
3 Citations
2.190 Impact Factor

Urinary bladder cancer in yemen.

Oman Med J 2013 Sep;28(5):337-40

Department of Pathology, Faculty of Medicine and Health Sciences Sana'a University. PO Box 13078 Sana'a, Yemen.

Objectives: The aims of this study are to highlight the clinicopathological features of urinary bladder cancer in Yemen, and to describe the histological grading of urothelial neoplasms according to the World Health Organization and International Society of Urologic pathology (WHO/ISUP 1998) classification.

Methods: This is a descriptive record-based study of 316 cases of bladder cancer diagnosed by two pathologists at the Department of pathology, Sana'a University from 1(st) January 2005 to 30(th) April 2009. The diagnoses were made on hematoxylin and eosin stained sections and categorized according to WHO/ISUP 1998 classification. Read More

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http://dx.doi.org/10.5001/omj.2013.97DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769118PMC
September 2013
42 Reads

Bovine papillomavirus type 2 infection and microscopic patterns of urothelial tumors of the urinary bladder in water buffaloes.

Biomed Res Int 2013 22;2013:937918. Epub 2013 May 22.

Department of Veterinary Medicine and Animal Productions, Naples University Federico II, Via Delpino 1, 80137 Naples, Italy.

Microscopic patterns of thirty-four urothelial tumors of the urinary bladder of water buffaloes from the Marmara and Black Sea Regions of Turkey are here described. All the animals grazed on lands rich in bracken fern. Histological diagnosis was assessed using morphological parameters recently suggested for the urinary bladder tumors of cattle. Read More

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http://downloads.hindawi.com/journals/bmri/2013/937918.pdf
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http://www.hindawi.com/journals/bmri/2013/937918/
Publisher Site
http://dx.doi.org/10.1155/2013/937918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3674648PMC
December 2013
28 Reads

Human papillomavirus is not an etiologic agent of urothelial inverted papillomas.

Am J Surg Pathol 2013 Aug;37(8):1223-8

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Inverted papilloma of the urinary bladder is rare, accounting for <1% of all bladder neoplasms. Although there is general consensus that inverted papilloma is benign in nature, little is known about its pathogenesis. Some have suggested that human papillomavirus (HPV) plays an etiologic role in the development of this neoplasm. Read More

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http://dx.doi.org/10.1097/PAS.0b013e3182863fc1DOI Listing
August 2013
21 Reads

[A case of inverted urothelial carcinoma of bladder].

Hinyokika Kiyo 2013 Apr;59(4):243-6

The Department of Urology, Sagamidai Hospital, Japan.

We present a case of inverted urothelial carcinoma of the bladder. A 60-year-old male was referred to our hospital for bilateral ureteral stones. When transurethral ureterolithotripsy was performed to treat these stones, a tumor at the trigone of bladder was incidentally diagnosed. Read More

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April 2013
25 Reads