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Bull Cancer 2018 Jun 1;105(6):556-561. Epub 2018 May 1.

Ospedale dei Bambini V. Buzzi, Pediatric Surgery Department, Via Castelvetro 32, 20154 Milano, Italy.

Objective: To report a series of 5 patients with urothelial bladder cancer (UBC) three of them with a history of exposure to amines and only two with gross hematuria.

Materials And Methods: After obtaining ethical and legal authorization, we performed a restrospective monocentric study. We collected information of patients with UBC over a period of 10 years. Read More

Ann Diagn Pathol 2017 Dec 17. Epub 2017 Dec 17.

Department of Oncologic Pathology and Prophylactics, Poznan University of Medical Sciences, Department of Oncologic Pathology, Greater Poland Cancer Center, Poland.

Tumours of the urinary tract are the fifth most frequent type of cancer. The most common types are urothelial tumours, among which, non-invasive urothelial neoplasms represent 45% of all cases. The 2016 WHO classification of urinary tract tumours introduced new classifications of non-invasive lesions. Read More

J Pediatr Surg 2018 Feb 14;53(2):306-309. Epub 2017 Nov 14.

Pediatric Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:

Purpose: Bladder cancer is the sixth most common cancer in the United States, but is exceedingly rare in young patients, leading to a lack of accepted standards for diagnosis, treatment, and surveillance. We review our institutional experience with bladder urothelial neoplasms in pediatric and young adult patients summarizing presentation, treatment, and outcomes.

Methods: Surgical pathology records at our institution were searched for cases of urothelial neoplasms among patients ≤25 years of age treated between January 1997 and September 2016. Read More

Histopathology 2018 Apr 4;72(5):795-803. Epub 2018 Jan 4.

Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan.

Aims: Mutations in FGFR3 and the promoter region of the telomerase reverse transcriptase (TERT) gene have been found frequently in urothelial carcinoma of the urinary bladder. However, related data for papillary urothelial neoplasm of low malignant potential (PUNLMP) are limited. In this study, we investigated the mutation status of the TERT promoter, FGFR3 and HRAS in low-grade papillary urothelial neoplasms and evaluated their prognostic significance. Read More

BMJ Case Rep 2017 May 13;2017. Epub 2017 May 13.

Department of Paediatrics, Hospital Center of Vila Nova de Gaia/Espinho, Vila Nova de Gaia, Portugal.

Bladder urothelial papilloma is extremely rare in the paediatric population. It usually presents as painless gross haematuria and its diagnosis implies a high index of suspicion as other causes of haematuria predominate in this age range. We describe a 9-year-old boy with two episodes of gross haematuria occurring 1 year apart with spontaneous resolution after 2 days. Read More

Cir Pediatr 2016 Jul 10;29(3):131-133. Epub 2016 Jul 10.

Servicio de Cirugía Pediátrica. Hospital Universitario Materno-Infantil. Badajoz.

Introduction: Vesical tumors of infancy are of a low incidence and isolated clinical cases exist, and therefore there are no protocols regarding treatment and monitoring. In addition, the histological criteria used until now are the ones in the WHO 2004 guidelines.

Clinical Case: A 11 year old boy with non-specific abdominal pain. Read More

J Appl Toxicol 2017 07 6;37(7):853-862. Epub 2017 Feb 6.

Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-Ku, Tokyo, 158-8501, Japan.

Horseradish extract (HRE), consisting mainly of a mixture of allyl isothiocyanate and other isothiocyanates, has been used as a food additive. To evaluate the potential hazards of HRE, a 104-week chronic study, a 2-week analysis of cell proliferation in the urinary bladder and a medium-term promotion bioassay of HRE were conducted with administration at concentrations of up to 0.04% HRE in the drinking water to male F344 rats. Read More

Eur Urol 2017 03 28;71(3):497-498. Epub 2016 Dec 28.

Unit of Anatomical Pathology, Faculty of Medicine, Cordoba, Spain; Champalimaud Clinical Center, Lisbon, Portugal.

Int J Surg 2016 Dec 5;36(Pt A):249-254. Epub 2016 Nov 5.

Department of Urology, Jinshan Hospital of Fudan University, Shanghai City, 201508, PR China. Electronic address:

Purpose: To investigate the association between preoperative plasma fibrinogen levels and clinicopathological features in patients with bladder urothelial tumors.

Methods: In this retrospective single-center study, we evaluated preoperative plasma fibrinogen levels in 503 patients newly diagnosed with bladder urothelial tumors between January 2009 and October 2014. All patients received surgical intervention as the primary treatment method. Read More

Anal Quant Cytopathol Histpathol 2016 Feb;38(1):52-6

Background: Inverted papilloma (IP) is an unusual benign neoplasm, most commonly found in the bladder. Cases of malignant transformation have been reported in the past, although most of them are now considered to be urothelial carcinomas with an inverted growth pattern.

Case: A 54-year-old man was diagnosed with urothelial carcinoma in situ (UCIS), high-grade papillary urothelial carcinoma (HGPUC), and IP by transurethral resection specimen of the bladder. Read More

Bull Exp Biol Med 2016 May 6;161(1):96-8. Epub 2016 Jun 6.

N. N. Blokhin Russian Cancer Research Center, Moscow, Russia.

Medical histories of 101 urothelial bladder cancer patients were compared with the results of morphological analysis and biomolecular detection of human papilloma viruses (HPV) in the tumor specimens. DNA of HPV16 (the major type of virus responsible for appearance of cervical carcinoma) was detected in 38 specimens, while mRNA of E6 and E7 oncogenes and E7 oncoprotein of HPV16 were observed in 13 specimens. HPV-positive bladder cancer was characterized by higher degree of cell anaplasia than HPV-negative cancer; in the primary bladder tumor, HPV was detected more often than in recurrent bladder cancer. Read More

Int Braz J Urol 2016 Mar-Apr;42(2):242-6

Dicle University, Faculty of Medicine, Department of Medical Pathology, Diyarbakir, Turkey.

Purpose: Bladder tumors are rare in children and adolescents. For this reason, the diagnosis is sometimes delayed in pediatric patients. We aimed to describe the diagnosis, treatment, and follow-up methods of bladder urothelial neoplasms in children and adolescents. Read More

Asian Pac J Cancer Prev 2016 ;17(4):1769-72

Department of Pathology, Faculty of Medicine, University of Tanta, Tanta, Egypt E-mail :

Background: Urothelial papilloma and non-invasive papillary carcinoma are common neoplasms of the urinary bladder. Distinguishing papillomas and papillary carcinomas, especially the low grade type, is often debatable on the basis of histological features alone.

Materials And Methods: We investigated immunohistochemical expression of cytokeratin 20 (CK20), p53, and Ki-67 in a group of 20 urothelial papilloma cases and 30 noninvasive papillary neoplasms of low malignant potential (PNLMP) of the urinary bladder. Read More

Chin J Cancer Res 2016 Feb;28(1):107-21

1 Department of Pathology, Chinese PLA General Hospital, Beijing 100853, China ; 2 Department of Pathology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310058, China.

Inverted lesions in the urinary bladder have been the source of some difficulty in urological pathology. The two common ones are von Brunn's nests and cystitis cystic/cystitis glandularis, which are considered normal variants of urothelium. Apart from them, a number of other rare urothelial lesions with inverted growth pattern occur in the urinary bladder. Read More

Ann Diagn Pathol 2016 Apr 17;21:7-11. Epub 2015 Dec 17.

Department of Pathology, Westchester Medical Center/New York Medical College, Valhalla, NY; Department of Pathology, Mount Sinai Medical Center, New York, NY. Electronic address:

Increased telomerase activity is associated with almost all types of advanced human cancers with unknown molecular mechanism(s). Two recurrent point mutations in the promoter region of telomerase reverse transcriptase (TERT)--the key subunit of telomerase--have recently been identified in melanoma as well as a small sample of bladder cancer cell lines. However, the incidence and clinical-pathological significance of these mutations in urothelial carcinoma have not been well established yet. Read More

Histopathology 2016 Jul 11;69(1):107-13. Epub 2016 Feb 11.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

Aims: To understand more clearly the genetic ontogeny of inverted papilloma of urinary bladder, we analysed telomerase reverse transcriptase (TERT) promoter mutation status in a group of 26 inverted papillomas in comparison with the mutation status of urothelial carcinoma with inverted growth (26 cases), conventional urothelial carcinoma (36 Ta non-invasive urothelial carcinoma, 35 T2 invasive urothelial carcinoma) and cystitis glandularis (25 cases).

Methods And Results: TERT promoter mutations in inverted papilloma, urothelial carcinoma with inverted growth, urothelial carcinoma and cystitis glandularis were found in 15% (four of 26), 58% (15 of 26), 63% (45 of 71) and 0% (none of 25), respectively. C228T mutations were the predominant mutations (97%) found in bladder tumours, while C250T aberrations occurred in approximately 3% of bladder tumours. Read More

Int J Exp Pathol 2015 Oct 30;96(5):319-25. Epub 2015 Oct 30.

Grupo de Patologia e Terapêutica Experimental, CI-IPOP, Instituto Português de Oncologia, Porto, Portugal.

Cytokeratins (CKs) 14 and 20 are promising markers for diagnosing urothelial lesions and for studying their prognosis and histogenesis. This work aimed to study the immunohistochemical staining patterns of CK14/20 during multistep carcinogenesis leading to papillary bladder cancer in a rat model. Thirty female Fischer 344 rats were divided into three groups: group 1 (control); group 2, which received N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) for 20 weeks plus 1 week without treatment; and group 3, which received BBN for 20 weeks plus 8 weeks without treatment. Read More

Adv Clin Exp Med 2015 May-Jun;24(3):505-9

Department of Palliative Care Nursing, Wroclaw Medical University, Poland; Department of Urology, 4th Military Clinical Hospital with Polyclinic, Wrocław, Poland.

Background: Bladder cancer occurs mainly in adults. In children, younger than 10 years in particular, it is very rare.

Objectives: The aim of the study is to retrospectively evaluate the efficacy of transurethral resection of the bladder tumour (TUR-BT) of transitional cell carcinoma (TCC) of the bladder in children. Read More

APMIS 2015 Nov 11;123(11):920-9. Epub 2015 Sep 11.

Department of Urology, Bispebjerg and Frederiksberg Hospitals, University of Copenhagen, Copenhagen, Denmark.

Inverted papilloma (IP) of the urinary tract is classified by the World Health Organisation as a non-invasive urothelial tumour with normal to minimal cytological atypia of the neoplastic cells. During the 1980s, it came under suspicion of having a premalignant or malignant potential and of being concurrent with urothelial cell carcinoma (UCC). This quandary has been proven difficult to solve, due to the fact that IP is very rare and literature mostly consists of case reports with varying levels of information, making strong meta-analyses problematic. Read More

Vet Pathol 2016 May 28;53(3):682-90. Epub 2015 Aug 28.

Cellular and Molecular Pathology Branch, National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA

o-Nitroanisole is an intermediate in the manufacture of azo dyes. In a National Toxicology Program stop-exposure study,o-nitroanisole induced hyperplasia, papillomas, and papillary carcinomas in the urinary bladder of Fischer 344/N rats.o-Nitroanisole was investigated since occupational or environmental exposure to aniline and azo dyes is a risk factor for urinary bladder cancer in humans. Read More

Hum Pathol 2015 Oct 26;46(10):1506-13. Epub 2015 Jun 26.

Department of Pathology, Hôpital du Sacré-Coeur de Montréal, Montreal, Quebec H4J1C5, Canada.

The current series presents 12 cases of invasive urothelial carcinoma (UC) with inverted growth pattern that fulfill the architectural criteria of the recently described "large nested" variant of UC, but which display a wider spectrum of morphologic and cytologic changes. All cases had an associated component of usual invasive UC, and 10 had an associated surface papillary component. Although many areas within the tumors were indistinguishable from a noninvasive endophytic growth pattern, at least some had an irregular ragged contour, and all showed haphazard arrangement with variable amount of intervening stroma at least focally. Read More

AJR Am J Roentgenol 2015 Aug;205(2):311-6

1 Department of Radiology, Nagoya City University Graduate School of Medical Sciences and Medical School, 1 Kawasumi Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-8601, Japan.

Objective: The objective of this study was to characterize MRI findings of inverted urothelial papilloma of the bladder.

Materials And Methods: Data pertaining to 16 patients with 18 pathologically proven inverted urothelial papillomas of the bladder who had undergone MRI were retrospectively collected from seven institutions. The shape and surface characteristics of the tumors were evaluated using T2-weighted MR images. Read More

Diagn Pathol 2015 Mar 13;10. Epub 2015 Mar 13.

Department of Pathology and Laboratory Medicine, Calgary Laboratory Service and University of Calgary, Rockyview General Hospital, 7007 14 Street, Calgary, AB, Canada.

Background: Few larger studies have evaluated the long-term outcome after a diagnosis of papillary urothelial neoplasm of low malignant potential (PUNLMP), demonstrating a broad range of recurrence and progression rates. Additionally, no study has addressed the outcome of PUNLMP exhibiting inverted growth. We evaluated the long term clinical outcome of primary papillary urothelial neoplasm of low malignant potential (PUNLMP), including PUNLMP with inverted growth in a large single center study. Read More

Epigenetics 2014 Dec;9(12):1626-40

a Molecular Oncology Group; Institute of Pathology ; RWTH Aachen University ; Aachen , Germany.

CREB3L1 has been recently proposed as a novel metastasis suppressor gene in breast cancer. Our current study highlights CREB3L1 expression, regulation, and function in bladder cancer. We demonstrate a significant downregulation of CREB3L1 mRNA expression (n = 64) in primary bladder cancer tissues caused by tumor-specific CREB3L1 promoter hypermethylation (n = 51). Read More

Histopathology 2015 Aug 19;67(2):255-61. Epub 2015 Feb 19.

Department of Pathology and Laboratory Medicine, Calgary Laboratory Services and University of Calgary, Calgary, AB, Canada.

Aims: To present a series of urinary bladder xanthomas and characterize their clinical features and associated pathology.

Methods And Results: We retrieved the clinicopathological data of bladder xanthomas, with and without associated urothelial neoplasms. We identified six isolated bladder xanthomas and 11 arising within or adjacent to urothelial neoplasms. Read More

J Pediatr Urol 2015 Feb 28;11(1):26.e1-5. Epub 2014 Sep 28.

Department Nephrology-Urology, Division of Pediatric Urology, 'Bambino Gesù' Children's Hospital Rome, IRCCS, Piazza S. Onofrio, 4, 00165 Roma, Italy. Electronic address:

Introduction: Urothelial bladder neoplasms (UBN) typically occur in patients in their sixth or seventh decade of life while they are infrequent in children and young adults. They occur in 0.1-0. Read More

Pathol Int 2014 Aug;64(8):375-81

Pathology and Laboratory Medicine, The Ottawa Hospital and University of Ottawa, Ottawa, Ontario, Canada.

Nested/microcystic (NV/MV) urothelial carcinoma (UC) variants are associated with mild cytologic atypia and commonly present at high-stage disease. The histopathogenesis is investigated using urothelial basal cell markers. Archival 14 NV/MV and three inverted papilloma (IP) were immunostained for CD44, cytokeratin 5 (CK5), CK34bE12 and p63. Read More

Am J Surg Pathol 2014 Nov;38(11):1516-21

*The Department of Pathology ‡Urology and Oncology, The Johns Hopkins Hospital, Baltimore, MD †Department of Pathology, Queen Elizabeth Hospital, Hong Kong, PR China.

Metastatic renal cell carcinoma (RCC) to the urinary bladder is rarely seen. Herein, we report the histologic subtypes, immunohistochemical characteristics, and prognosis of 11 patients with metastatic RCC to the urinary bladder. The mean age at the time of diagnosis of metastatic RCC to the bladder was 66 years (range, 58 to 79 y). Read More

Hum Pathol 2014 Sep 18;45(9):1957-65. Epub 2014 Jun 18.

Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:

Inverted urothelial papilloma (IUP) is an uncommon neoplasm of the urinary bladder with distinct morphologic features. Studies regarding the role of human papillomavirus (HPV) in the etiology of IUP have provided conflicting evidence of HPV infection. In addition, little is known regarding the molecular alterations present in IUP or other urothelial neoplasms, which might demonstrate inverted growth pattern like low-grade or high-grade urothelial carcinoma (UCA). Read More

Mod Pathol 2014 Nov 18;27(11):1540-8. Epub 2014 Apr 18.

1] Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA [2] Department of Urology, Indiana University School of Medicine, Indianapolis, IN, USA.

Urothelial neoplasms in children and young adult patients are rare and hypothesized to have a lower rate of recurrence and progression than those of older adults. Because of their rarity, data regarding molecular abnormalities in these tumors are limited. We studied molecular characteristics of urothelial neoplasms from patients under age 30 years using UroVysion fluorescence in situ hybridization (chromosomes 3, 7, 17, and 9p21) and DNA mutational analysis for the FGFR3 and TP53 genes. Read More

PLoS One 2013 27;8(11):e81081. Epub 2013 Nov 27.

Department of Pathology, University of California San Diego, La Jolla, California, United States of America.

Bladder cancer is the fourth most common cause of cancer in males in the United States. Invasive behavior is a major determinant of prognosis. In this study, we identified mammalian target of rapamycin complex 2 (mTORC2) as a central regulator of bladder cancer cell migration and invasion. Read More

Pathology 2014 Jan;46(1):37-40

1Department of Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Calgary 2Division of Urology, University of Calgary, Calgary, Alberta, Canada.

The aim of this study was to investigate the long term outcome of primary urothelial papilloma (UP). We retrieved 41 primary UP, diagnosed between January 2000 and December 2009. Follow-up was obtained by searching pathology and clinical electronic databases. Read More

Radiol Oncol 2013 8;47(4):338-45. Epub 2013 Oct 8.

Institute of Cell Biology, Faculty of Medicine, Ljubljana, Slovenia.

Background: Uroplakins are differentiation-related membrane proteins of urothelium. We compared uroplakin expression and ultrastructural localization in human normal urothelium, papilloma and papillary carcinoma. Because of high recurrence rate of these tumours, treated by transurethral resection, we investigated urothelial tumour, resection border and uninvolved urothelium. Read More

Urology 2013 Oct;82(4):857-60

Department of Pathology and Laboratory Medicine, University of Calgary and Calgary Laboratory Services, Calgary, Alberta, Canada.

Objective: To investigate the necessity for continuous cystoscopic surveillance of inverted papilloma (IP), including tumors exhibiting mixed morphology (IP with focal papillary architecture).

Methods: We retrieved all cases of de novo ("primary") IP, diagnosed in our institution during 10 years (from January 2000 to December 2009), from the information database. Patients with a history of urothelial carcinoma or concurrent urothelial carcinoma were excluded. Read More

Oman Med J 2013 Sep;28(5):337-40

Department of Pathology, Faculty of Medicine and Health Sciences Sana'a University. PO Box 13078 Sana'a, Yemen.

Objectives: The aims of this study are to highlight the clinicopathological features of urinary bladder cancer in Yemen, and to describe the histological grading of urothelial neoplasms according to the World Health Organization and International Society of Urologic pathology (WHO/ISUP 1998) classification.

Methods: This is a descriptive record-based study of 316 cases of bladder cancer diagnosed by two pathologists at the Department of pathology, Sana'a University from 1(st) January 2005 to 30(th) April 2009. The diagnoses were made on hematoxylin and eosin stained sections and categorized according to WHO/ISUP 1998 classification. Read More

Biomed Res Int 2013 22;2013:937918. Epub 2013 May 22.

Department of Veterinary Medicine and Animal Productions, Naples University Federico II, Via Delpino 1, 80137 Naples, Italy.

Microscopic patterns of thirty-four urothelial tumors of the urinary bladder of water buffaloes from the Marmara and Black Sea Regions of Turkey are here described. All the animals grazed on lands rich in bracken fern. Histological diagnosis was assessed using morphological parameters recently suggested for the urinary bladder tumors of cattle. Read More

Am J Surg Pathol 2013 Aug;37(8):1223-8

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Inverted papilloma of the urinary bladder is rare, accounting for <1% of all bladder neoplasms. Although there is general consensus that inverted papilloma is benign in nature, little is known about its pathogenesis. Some have suggested that human papillomavirus (HPV) plays an etiologic role in the development of this neoplasm. Read More

Hinyokika Kiyo 2013 Apr;59(4):243-6

The Department of Urology, Sagamidai Hospital, Japan.

We present a case of inverted urothelial carcinoma of the bladder. A 60-year-old male was referred to our hospital for bilateral ureteral stones. When transurethral ureterolithotripsy was performed to treat these stones, a tumor at the trigone of bladder was incidentally diagnosed. Read More

Int J Clin Exp Pathol 2013 15;6(4):766-70. Epub 2013 Mar 15.

Department of Pathology, Shizuoka City Shimizu Hospital, Shizuoka, Japan.

Inverted urothelial carcinoma (UC) without papillary areas is very rare; only 31 cases of three papers have been reported. The author herein reports three additional cases, and proposes the term "inverted variant" (IV) of UC. The materials were 3 cases of IV of UC, 5 cases of inverted papilloma (IP), and two cases of nested variant (NV) of UC. Read More

Hinyokika Kiyo 2013 Feb;59(2):121-4

The Department of Urology, Tsudanuma Central General Hospital, Japan.

The patient visited our hospital because of macrohematuria. Cystoscopical examination did not reveal any bladder tumors but a tumor shadow in the right renal pelvis was revealed by computed tomographic scan. Urothelial carcinoma was suspected and right nephroureterectomy was performed. Read More

Biomed Pharmacother 2013 Apr 7;67(3):183-91. Epub 2012 Dec 7.

Medical Biochemistry Department, Faculty of Medicine, Cairo University, Giza, Egypt.

Aims: To detect human papilloma virus (HPV) infection, p21 oncogene, DNA content of urothelial cells in different bladder lesions with and without schistosomiasis and to correlate them with histopathological grade and stage.

Methods: Eighty-five patients were enrolled: 25 chronic cystitis and 60 malignant bladder lesions; 15 schistosomal squamous cell carcinoma (SQCC), 45 urothelial carcinoma (transitional cell carcinoma TCC) schistosomal and non-scistosomal. Ten healthy individuals served as controls. Read More

Pathology 2013 04;45(3):243-50

Aquesta Pathology, University of Queensland, Brisbane, Queensland, Australia.

Although most carcinomas of the bladder occur de novo, some vesical lesions progress to malignancy over time. These lesions appear morphologically benign, but often harbour genetic changes that signify their malignant potential. Despite their benign appearance, accurate identification is important given that these patients will require close follow-up. Read More

Clin Cancer Res 2013 Apr 12;19(7):1717-28. Epub 2013 Feb 12.

Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

Purpose: Despite more than 70,000 new cases of bladder cancer in the United States annually, patients with advanced disease have a poor prognosis due to limited treatment modalities. We evaluated Aurora kinase A, identified as an upregulated candidate molecule in bladder cancer, as a potential therapeutic target.

Experimental Design: Gene expression in human bladder cancer samples was evaluated using RNA microarray and quantitative reverse transcriptase PCR. Read More

Histopathology 2013 Mar 5;62(4):595-601. Epub 2013 Feb 5.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Aims: To investigate relative telomere length in inverted urothelial neoplasms, including inverted papilloma and urothelial carcinoma with an inverted growth pattern. Telomere shortening has been implicated as an early event in the development of epithelial malignancies in a number of organ systems.

Methods And Results: Formalin-fixed, paraffin-embedded tissue sections from 77 cases were studied, including 26 cases of inverted papilloma, 26 urothelial carcinomas with inverted growth, and 25 cases of cystitis glandularis. Read More

Rare Tumors 2012 Jun 14;4(3):e45. Epub 2012 Sep 14.

Department of Pathology, Istanbul Education and Research Hospital, Ministry of Health, Istanbul;

Abundant myxoid stroma rarely occurs in urothelial carcinomas, and may cause diagnostic challenges when cells with eosinophilic cytoplasm forming nests and cords in a myxoid background are seen, particularly in the absence of typical carcinomatous appearance. Microscopic examination of transurethral resection specimen of a 71-year-old male patient revealed non-cohesive oval or elongated tumor cells with eosinophilic cytoplasm arranged in cord-like filigree pattern in an abundant myxoid stroma. Immunohistochemically the tumor was positive for cytokeratin 7, cytokeratin 20, and 34BE12. Read More

Hinyokika Kiyo 2012 Sep;58(9):471-4

The Department of Urology, Chigasaki City Hospital, Japan.

Inverted papilloma of the bladder is an uncommon urothelial neoplasm. Although it is traditionally regarded as a benign tumor, there are conflicting data on multiplicity, reoccurrence rate, and association with urothelial carcinoma. From 2005 to 2011, 14 cases of inverted papilloma of the bladder were diagnosed at our hospital. Read More

Arch Esp Urol 2012 Sep;65(7):709-13

Pathology Department, Consorcio, Hospital General Universitario, Hospital Casa Salud, Valencia, Spain.

Objective: Inverted papilloma of the urinary bladder is an uncommon urothelial neoplasm that may be specially difficult to distinguish from urothelial carcinoma.

Methods: Two patients with obstructive symptoms and hematuria have been studied. In the transurethral resection, accidentally, one showed a papillary lesion in the context of nodular hyperplasia of the prostate, where as the other showed a polypoid tumor of the urinary bladder

Results: Histologically, in both cases, a bladder inverted papilloma was demonstrated, originating from the surface transitional epithelium. Read More

Am J Clin Nutr 2012 Oct 5;96(4):902-10. Epub 2012 Sep 5.

National Institute for Public Health and the Environment, Bilthoven, Netherlands.

Background: Published associations between dietary carotenoids and vitamin C and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status.

Objective: We investigated the association between plasma carotenoids and vitamin C and risk of urothelial cell carcinoma (UCC) in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. Read More

Asian Pac J Cancer Prev 2012 ;13(6):2477-9

Department of Pathology, Regional Institute of Medical Sciences Lamphelpat, Imphal, Manipur State, India.

Objective: To study the histomorphological pattern of urothelial tumors of the urinary bladder in Manipur and to evaluate whether any correlation exists between tumor grade and muscle invasion.

Methods: A 10 year retrospective study of all consecutive cases diagnosed in the Department of Pathology RIMS - Imphal, between 1st January 2001 to 31st December 2010.

Results: The study included 26 cases of transitional cell tumors of urinary bladder. Read More